Search

Your search keyword '"Hamid, Syed"' showing total 401 results
Start Over Author "Hamid, Syed"
401 results on '"Hamid, Syed"'

3. Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression

Author

Yildirim, Zehra, Baboo, Sabyasachi, Hamid, Syed M, Dogan, Asli E, Tufanli, Ozlem, Robichaud, Sabrina, Emerton, Christina, Diedrich, Jolene K, Vatandaslar, Hasan, Nikolos, Fotis, Gu, Yanghong, Iwawaki, Takao, Tarling, Elizabeth, Ouimet, Mireille, Nelson, David L, Yates, John R, Walter, Peter, and Erbay, Ebru

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cardiovascular, Intellectual and Developmental Disabilities (IDD), Brain Disorders, Rare Diseases, Atherosclerosis, Fragile X Syndrome, 2.1 Biological and endogenous factors, Animals, Endoplasmic Reticulum Stress, Endoribonucleases, Fragile X Mental Retardation Protein, Membrane Proteins, Mice, Protein Serine-Threonine Kinases, Signal Transduction, atherosclerosis, cholesterol homeostasis, efferocytosis, ER stress, translational regulation, Medical and Health Sciences, Biochemistry and cell biology
Abstract

Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA-binding protein (RBP) that controls translation of select mRNAs. We discovered that endoplasmic reticulum (ER) stress induces phosphorylation of FMRP on a site that is known to enhance translation inhibition of FMRP-bound mRNAs. We show ER stress-induced activation of Inositol requiring enzyme-1 (IRE1), an ER-resident stress-sensing kinase/endoribonuclease, leads to FMRP phosphorylation and to suppression of macrophage cholesterol efflux and apoptotic cell clearance (efferocytosis). Conversely, FMRP deficiency and pharmacological inhibition of IRE1 kinase activity enhances cholesterol efflux and efferocytosis, reducing atherosclerosis in mice. Our results provide mechanistic insights into how ER stress-induced IRE1 kinase activity contributes to macrophage cholesterol homeostasis and suggests IRE1 inhibition as a promising new way to counteract atherosclerosis.

Published
2022

4. Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study

Author

Ercan, Ayse Bahar, Aronson, Melyssa, Fernandez, Nicholas R, Chang, Yuan, Levine, Adrian, Liu, Zhihui Amy, Negm, Logine, Edwards, Melissa, Bianchi, Vanessa, Stengs, Lucie, Chung, Jiil, Al-Battashi, Abeer, Reschke, Agnes, Lion, Alex, Ahmad, Alia, Lassaletta, Alvaro, Reddy, Alyssa T, Al-Darraji, Amir F, Shah, Amish C, Van Damme, An, Bendel, Anne, Rashid, Aqeela, Margol, Ashley S, Kelly, Bethany L, Pencheva, Bojana, Heald, Brandie, Lemieux-Anglin, Brianna, Crooks, Bruce, Koschmann, Carl, Gilpin, Catherine, Porter, Christopher C, Gass, David, Samuel, David, Ziegler, David S, Blumenthal, Deborah T, Kuo, Dennis John, Hamideh, Dima, Basel, Donald, Khuong-Quang, Dong-Anh, Stearns, Duncan, Opocher, Enrico, Carceller, Fernando, Baris Feldman, Hagit, Toledano, Helen, Winer, Ira, Scheers, Isabelle, Fedorakova, Ivana, Su, Jack M, Vengoechea, Jaime, Sterba, Jaroslav, Knipstein, Jeffrey, Hansford, Jordan R, Gonzales-Santos, Julieta Rita, Bhatia, Kanika, Bielamowicz, Kevin J, Minhas, Khurram, Nichols, Kim E, Cole, Kristina A, Penney, Lynette, Hjort, Magnus Aasved, Sabel, Magnus, Gil-da-Costa, Maria Joao, Murray, Matthew J, Miller, Matthew, Blundell, Maude L, Massimino, Maura, Al-Hussaini, Maysa, Al-Jadiry, Mazin F, Comito, Melanie A, Osborn, Michael, Link, Michael P, Zapotocky, Michal, Ghalibafian, Mithra, Shaheen, Najma, Mushtaq, Naureen, Waespe, Nicolas, Hijiya, Nobuko, Fuentes-Bolanos, Noemi, Ahmad, Olfat, Chamdine, Omar, Roy, Paromita, Pichurin, Pavel N, Nyman, Per, Pearlman, Rachel, Auer, Rebecca C, Sukumaran, Reghu K, Kebudi, Rejin, Dvir, Rina, Raphael, Robert, Elhasid, Ronit, McGee, Rose B, Chami, Rose, Noss, Ryan, Tanaka, Ryuma, Raskin, Salmo, Sen, Santanu, Lindhorst, Scott, Perreault, Sebastien, Caspi, Shani, Riaz, Shazia, Constantini, Shlomi, Albert, Sophie, Chaleff, Stanley, Bielack, Stefan, Chiaravalli, Stefano, Cramer, Stuart Louis, Roy, Sumita, Cahn, Suzanne, Penna, Suzanne, Hamid, Syed Ahmer, Ghafoor, Tariq, Imam, Uzma, Larouche, Valerie, Magimairajan Issai, Vanan, Foulkes, William D, Lee, Yi Yen, Nathan, Paul C, Maruvka, Yosef E, Greer, Mary-Louise C, Durno, Carol, Shlien, Adam, Ertl-Wagner, Birgit, Villani, Anita, Malkin, David, Hawkins, Cynthia, Bouffet, Eric, Das, Anirban, and Tabori, Uri

Published
2024
Full Text
View/download PDF

5. Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries

Author

Kaliki, Swathi, Vempuluru, Vijitha S., Mohamed, Ashik, Abdulqader, Rula Ahmed, Aggarwal, Priyanka, Ahmad, Alia, Akib, Marliyanti Nur Rahmah, Al Mesfer, Saleh A., Al Ani, Mouroge Hashim, Al-Badri, Safaa A.Faraj, Angeles Alcasabas, Ana Patricia, Al-Dahmash, Saad A., Al-Haddad, Christiane, Yahya Al-Hussaini, Hamoud Hodeish, Al-Jadiry, Mazin Faisal, Al-Jumaily, Usama, Alkatan, Hind Manaa, Razzaq Mahmood Al-Mafrachi, Ali Abdul, Samad Majeed Al-Shaheen, Athar Abdul, Al-Shammary, Entissar Hadi, Amiruddin, Primawita Oktarima, Armytasari, Inggar, Astbury, Nicholas John, Atalay, Hatice Tuba, Ataseven, Eda, Atchaneeyasakul, La-ongsri, Balayeva, Ruhengiz, Bascaran, Covadonga, Begimkulova, Ainura Suranovna, Bhaduri, Anirban, Bhat, Sunil, Bhattacharyya, Arpita, Blum, Sharon, Bowman, Richard, Buaboonnam, Jassada, Burton, Matthew J., Caspi, Shani, Chaudhry, Shabana, Chawla, Bhavna, Chen, Wensi, Chuluunbat, Tsengelmaa, Dangboon, Wantanee, Das, Anirban, Das, Pranab, Das, Sima, Du, Yi, Dudeja, Gagan, Eka Sutyawan, I Wayan, Fadoo, Zehra, Faranoush, Mohammad, Foster, Allen, Frenkel, Shahar, Ghassemi, Fariba, Gomel, Nir, Gunasekera, D Sanjeeva, Gündüz, Ahmet K., Gupta, Himika, Gupta, Sanjiv, Gupta, Vineeta, Hamid, Syed Ahmer, Hamzah, Norhafizah, Hasanreisoglu, Murat, Hassan, Shadab, Haydar, Huda Awni, Hongeng, Suradej, Hussein Al-Janabi, Allawi Noor, Islamov, Ziyavuddin, Janjua, Teyyeb Azeem, Jeeva, Irfan, Ji, Xunda, Jo, Dong Hyun, Kantar, Mehmet, Kapelushnik, Noa, Kebudi, Rejin, Keomisy, Jonny, Khan, Zohora Jameela, Khaqan, Hussain Ahmed, Khetan, Vikas, Khodabande, Alireza, Kim, Jeong Hun, Kiratli, Hayyam, Koç, Irem, Kulvichit, Kittisak, Kuntorini, Mayasari Wahyu, Li, Cairui, Li, Kaijun, Limbu, Ben, Liu, ChunHsiu, Lutfi, Delfitri, Mahajan, Amita, Maitra, Puja, Makimbetov, Emil Kojoshovich, Maktabi, Azza M.Y., Manzhuova, Lyazat, Masud, Sidra, Mehrvar, Azim, Menon, Vikas, John V Mercado, Gary, Chandra Mishra, Divyansh Kailash, Mohammad, Mona Tayseer, Mudaliar, Sangeeta Sanjay, Mushtaq, Asma, Nair, Akshay Gopinathan, Natarajan, Sundaram, Nency, Yetty Movieta, Neroev, Vladimir, Nuruddin, Murtuza, Pagarra, Halimah, Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Pe'er, Jacob, Polyakov, Vladimir, Qadir, Ali Omer, Qayyum, Seema, Qian, Jiang, Quah, BoonLong, Rahman, Ardizal, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Rashid, Riffat, Rojanaporn, Duangnate, Roy, Soma Rani, Saab, Raya Hamad, Saakyan, Svetlana, Sabhan, Ahmed Hatem, Saiju, Rohit, Sayalith, Phayvanh, Sedaghat, Ahad, Seth, Rachna, Shakoor, Shawkat Ara, Sharma, Manoj Kumar, Siddiqui, Sorath Noorani, Singh, Usha, Singha, Penny, Sitorus, Rita S., Soebagjo, Hendrian D., Sultana, Sadia, Sun, Xiantao, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Tan, Deborah, Tang, Jing, Tashvighi, Maryam, Teh, Kok Hoi, Tehuteru, Edi Setiawan, Thawaba, Abdullah Dahan M., Toledano, Helen, Le Trang, Doan, Tripathy, Devjyoti, Tuncer, Samuray, Unal, Emel, Ushakova, Tatiana L., Usmanov, Rustam, Verma, Nishant, Victor, Andi Arus, Vishnevskia-Dai, Victoria, Wang, Yi-Zhuo, Wangtiraumnuay, Nutsuchar, Riono, Widiarti Pandu, Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wong, Emily S., Wongwai, Phanthipha, Wu, Si-qi, Xiang, Daoman, Xiao, Yishuang, Xu, Bing, Xue, Kang, Yam, Jason C., Yang, Huasheng, Yaqub, Muhammad Amer, Yarovaya, Vera A., Yarovoy, Andrey A., Ye, Huijing, Yousef, Yacoub Abdallah, Yuliawati, Putu, Zhang, Yi, Zia, Nida, Zondervan, Marcia, Fabian, Ido Didi, and Sthapit, Purnima Rajkarnikar

Published
2024
Full Text
View/download PDF

6. Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Author

Durno, Carol, Ercan, Ayse Bahar, Bianchi, Vanessa, Edwards, Melissa, Aronson, Melyssa, Galati, Melissa, Atenafu, Eshetu G, Abebe-Campino, Gadi, Al-Battashi, Abeer, Alharbi, Musa, Azad, Vahid Fallah, Baris, Hagit N, Basel, Donald, Bedgood, Raymond, Bendel, Anne, Ben-Shachar, Shay, Blumenthal, Deborah T, Blundell, Maude, Bornhorst, Miriam, Bronsema, Annika, Cairney, Elizabeth, Rhode, Sara, Caspi, Shani, Chamdin, Aghiad, Chiaravalli, Stefano, Constantini, Shlomi, Crooks, Bruce, Das, Anirban, Dvir, Rina, Farah, Roula, Foulkes, William D, Frenkel, Zehavit, Gallinger, Bailey, Gardner, Sharon, Gass, David, Ghalibafian, Mithra, Gilpin, Catherine, Goldberg, Yael, Goudie, Catherine, Hamid, Syed Ahmer, Hampel, Heather, Hansford, Jordan R, Harlos, Craig, Hijiya, Nobuko, Hsu, Saunders, Kamihara, Junne, Kebudi, Rejin, Knipstein, Jeffrey, Koschmann, Carl, Kratz, Christian, Larouche, Valerie, Lassaletta, Alvaro, Lindhorst, Scott, Ling, Simon C, Link, Michael P, De Mola, Rebecca Loret, Luiten, Rebecca, Lurye, Michal, Maciaszek, Jamie L, MagimairajanIssai, Vanan, Maher, Ossama M, Massimino, Maura, McGee, Rose B, Mushtaq, Naureen, Mason, Gary, Newmark, Monica, Nicholas, Garth, Nichols, Kim E, Nicolaides, Theodore, Opocher, Enrico, Osborn, Michael, Oshrine, Benjamin, Pearlman, Rachel, Pettee, Daniel, Rapp, Jan, Rashid, Mohsin, Reddy, Alyssa, Reichman, Lara, Remke, Marc, Robbins, Gabriel, Roy, Sumita, Sabel, Magnus, Samuel, David, Scheers, Isabelle, Schneider, Kami Wolfe, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Swallow, Carol, Taylor, Leslie, Thomas, Gregory, Toledano, Helen, Tomboc, Patrick, Van Damme, An, Winer, Ira, Yalon, Michal, Yen, Lee Yi, Zapotocky, Michal, Zelcer, Shayna, and Ziegler, David S

Subjects
Cancer, Brain Disorders, Clinical Research, Digestive Diseases, Prevention, Brain Cancer, Rare Diseases, Adolescent, Adult, Brain Neoplasms, Child, Child, Preschool, Colorectal Neoplasms, DNA Mismatch Repair, DNA Repair Enzymes, Early Detection of Cancer, Female, Follow-Up Studies, Humans, Male, Neoplastic Syndromes, Hereditary, Population Surveillance, Prognosis, Prospective Studies, Survival Rate, United States, Young Adult, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeConstitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals.Patients and methodsData were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort. Survival outcomes were analyzed for patients followed prospectively from the time of surveillance implementation.ResultsA total of 193 malignant tumors in 110 patients were identified. Median age of first cancer diagnosis was 9.2 years (range: 1.7-39.5 years). For patients undergoing surveillance, all GI and other solid tumors, and 75% of brain cancers were detected asymptomatically. By contrast, only 16% of hematologic malignancies were detected asymptomatically (P < .001). Eighty-nine patients were followed prospectively and used for survival analysis. Five-year overall survival (OS) was 90% (95% CI, 78.6 to 100) and 50% (95% CI, 39.2 to 63.7) when cancer was detected asymptomatically and symptomatically, respectively (P = .001). Patient outcome measured by adherence to the surveillance protocol revealed 4-year OS of 79% (95% CI, 54.8 to 90.9) for patients undergoing full surveillance, 55% (95% CI, 28.5 to 74.5) for partial surveillance, and 15% (95% CI, 5.2 to 28.8) for those not under surveillance (P < .0001). Of the 64 low-grade tumors detected, the cumulative likelihood of transformation from low-to high-grade was 81% for GI cancers within 8 years and 100% for gliomas in 6 years.ConclusionSurveillance and early cancer detection are associated with improved OS for individuals with CMMRD.

Published
2021

7. Rhythmic Pattern of EEG for Identifying Schizophrenia

Author

Hussain, Sh Hussain, Noman, Fuad M., Hussain, Hadri, Ting, Chee-Ming, Hamid, Syed Rasul Bin G. Syed, Hussain, Siti Hadrina Bt Sheikh, Jalil, M. A., Ahmad Zubaidi, A. L., Zuhaib, Syed, Kipli, Kuryati bt, Jacob, Kavikumar, Ray, Kanad, Kaiser, M. Shamim, Mahmud, Mufti, Ali, Jalil, Bandyopadhyay, Anirban, Series Editor, Ray, Kanad, Series Editor, Poon, Chi-Sang, Series Editor, Kaiser, M. Shamim, editor, Mahmud, Mufti, editor, and Al Mamun, Shamim, editor

Published
2022
Full Text
View/download PDF

8. Classification of ECG Ventricular Beats Assisted by Gaussian Parameters’ Dictionary

Author

Salleh, Sh Hussain, Noman, Fuad, Hussain, Hadri, Ting, Chee-Ming, Hamid, Syed Rasul bin G. Syed, Sh-Hussain, Hadrina, Jalil, M. A., Zubaidi, A. L. Ahmad, Rizvi, Syed Zuhaib Haider, Kipli, Kuryati, Jacob, Kavikumar, Ray, Kanad, Kaiser, M. Shamim, Mahmud, Mufti, Ali, Jalil, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Kaiser, M. Shamim, editor, Ray, Kanad, editor, Bandyopadhyay, Anirban, editor, Jacob, Kavikumar, editor, and Long, Kek Sie, editor

Published
2022
Full Text
View/download PDF

9. A Brief Review of Computation Techniques for ECG Signal Analysis

Author

Hussain, Salleh Sh, Noman, Fuad, Hussain, Hadri, Ting, Chee-Ming, bin Hamid, Syed Rasul G. Syed, Sh-Hussain, Hadrina, Jalil, M. A., A.L., Ahmad Zubaidi, Rizvi, Syed Zuhaib Haider, Kipli, Kuryati, Jacob, Kavikumar, Ray, Kanad, Shamim Kaiser, M., Mahmud, Mufti, Ali, Jalil, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Kaiser, M. Shamim, editor, Ray, Kanad, editor, Bandyopadhyay, Anirban, editor, Jacob, Kavikumar, editor, and Long, Kek Sie, editor

Published
2022
Full Text
View/download PDF

12. Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study

Author

Chaudry, Aasem, Sharma, Abhishek, Bennett, Adam, Ahmad, Adnan, Abroaf, Ahmed, Suliman, Ahmed Musa, Lloyd, Aimee, McKay, Alastair, Wong, Albert, Silva, Alberto, Schneider, Alexandre, MacKay, Alison, Knight, Allen, Grigorakis, Alkiviadis, Bdesha, Amar, Nagle, Amy, Cebola, Ana, Dhanasekaran, Ananda Kumar, Kondža, Andraž, Barcelos, André, Galosi, Andrea Benedetto, Ebur, Andrea, Minervini, Andrea, Russell, Andrew, Webb, Andrew, de Jalón, Ángel García, Desai, Ankit, Czech, Anna Katarzyna, Mainwaring, Anna, Adimonye, Anthony, Das, Arighno, Figueiredo, Arnaldo, Villers, Arnauld, Leminski, Artur, Chippagiri, Arvinda, Lal, Asim Ahmed, Yıldırım, Asıf, Voulgaris, Athanasios Marios, Uzan, Audrey, Oo, Aye Moh Moh, Younis, Ayman, Zelhof, Bachar, Mukhtar, Bashir, Ayres, Ben, Challacombe, Ben, Sherwood, Benedict, Ristau, Benjamin, Lai, Billy, Nellensteijn, Brechtje, Schreiter, Brielle, Trombetta, Carlo, Dowling, Catherine, Hobbs, Catherine, Benitez, Cayo Augusto Estigarribia, Lebacle, Cédric, Ho, Cherrie Wing Yin, Ng, Chi-Fai, Mount, Chloe, Lam, Chon Meng, Blick, Chris, Brown, Christian, Gallegos, Christopher, Higgs, Claire, Browne, Clíodhna, McCann, Conor, Plaza Alonso, Cristina, Beder, Daniel, Cohen, Daniel, Gordon, Daniel, Wilby, Daniel, Gordon, Danny, Hrouda, David, Lau, David Hua Wu, Karsza, Dávid, Mak, David, Martin-Way, David, Suthaharan, Denula, Patel, Dhruv, Carrion, Diego M, Nyanhongo, Donald, Bass, Edward, Mains, Edward, Chau, Edwin, Canelon Castillo, Elba, Day, Elizabeth, Desouky, Elsayed, Gaines, Emily, Papworth, Emma, Yuruk, Emrah, Kilic, Enes, Dinneen, Eoin, Palagonia, Erika, Xylinas, Evanguelos, Khawaja, Faizan, Cimarra, Fernando, Bardet, Florian, Kum, Francesca, Peters, Francesca, Kovács, Gábor, Tanasescu, Geroge, Hellawell, Giles, Tasso, Giovanni, Lam, Gitte, La Montagna, Giuseppe, Pizzuto, Giuseppe, Lenart, Gordan, MacLennan, Graeme, Özgür, Günal, Bi, Hai, Lyons, Hannah, Warren, Hannah, Ahmed, Hashim, Simpson, Helen, Burden, Helena, Gresty, Helena, Rios Pita, Hernado, Clarke, Holly, Serag, Hosam, Kynaston, Howard, Crawford-Smith, Hugh, Mostafid, Hugh, Otaola-Arca, Hugo, Koo, Hui Fen, Ibrahim, Ibrahim, Ouzaid, Idir, Puche-Sanz, Ignacio, Tomašković, Igor, Tinay, Ilker, Sahibzada, Iqbal, Thangasamy, Isaac, Cadena, Iván Revelo, Irani, Jacques, Udzik, Jakub, Brittain, James, Catto, James, Green, James, Tweedle, James, Hernando, Jamie Borrego, Leask, Jamie, Kalsi, Jas, Frankel, Jason, Toniolo, Jason, Raman, Jay D., Courcier, Jean, Kumaradeevan, Jeevan, Clark, Jennifer, Jones, Jennifer, Teoh, Jeremy Yuen-Chun, Iacovou, John, Kelly, John, Selph, John P., Aning, Jonathan, Deeks, Jon, Cobley, Jonathan, Olivier, Jonathan, Maw, Jonny, Herranz-Yagüe, José Antonio, Nolazco, Jose Ignacio, Cózar-Olmo, Jose Manuel, Bagley, Joseph, Jelski, Joseph, Norris, Joseph, Testa, Joseph, Meeks, Joshua, Hernandez, Juan, Vásquez, Juan Luis, Randhawa, Karen, Dhera, Karishma, Gronostaj, Katarzyna, Houlton, Kathleen, Lehman, Kathleen, Gillams, Kathryn, Adasonla, Kelvin, Brown, Kevin, Murtagh, Kevin, Mistry, Kiki, Davenport, Kim, Kitamura, Kosuke, Derbyshire, Laura, Clarke, Laurence, Morton, Lawrie, Martinez, Levin, Goldsmith, Louise, Paramore, Louise, Cormier, Luc, Dell'Atti, Lucio, Simmons, Lucy, Martinez-Piñeiro, Luis, Rico, Luis, Chan, Luke, Forster, Luke, Ma, Lulin, Moore, Madeline, Gallego, Maria Camacho, Freire, Maria José, Emberton, Mark, Feneley, Mark, Antón-Juanilla, Marta, Rivero, Marta Viridiana Muñoz, Pirša, Matea, Tallè, Matteo, Crockett, Matthew, Liew, Matthew, Trail, Matthew, Peters, Max, Cooper, Meghan, Kulkarni, Meghana, Ager, Michael, He, Ming, Li, Mo, Omran Breish, Mohamed, Tarin, Mohamed, Aldiwani, Mohammed, Matanhelia, Mudit, Pasha, Muhammad, Akalın, Mustafa Kaan, Abdullah, Nasreen, Hale, Nathan, Gadiyar, Neha, Kocher, Neil, Bullock, Nicholas, Campain, Nicholas, Pavan, Nicola, Al-Ibraheem, Nihad, Bhatt, Nikita, Bedi, Nishant, Shrotri, Nitin, Lobo, Niyati, Balderas, Olga, Kouli, Omar, Capoun, Otakar, Oteo Manjavacas, Pablo, Gontero, Paolo, Mariappan, Paramananthan, Marchiñena, Patricio Garcia, Erotocritou, Paul, Sweeney, Paul, Planelles, Paula, Acher, Peter, Black, Peter C., Osei-Bonsu, Peter K, Østergren, Peter, Smith, Peter, Willemse, Peter-Paul Michiel, Chlosta, Piotr L., Ul Ain, Qurrat, Barratt, Rachel, Esler, Rachel, Khalid, Raihan, Hsu, Ray, Stamirowski, Remigiusz, Mangat, Reshma, Cruz, Ricardo, Ellis, Ricky, Adams, Robert, Hessell, Robert, Oomen, Robert J.A., McConkey, Robert, Ritchie, Robert, Jarimba, Roberto, Chahal, Rohit, Andres, Rosado Mario, Hawkins, Rosalyn, David, Rotimi, Manecksha, Rustom P., Agrawal, Sachin, Hamid, Syed Sami, Deem, Samuel, Goonewardene, Sanchia, Swami, Satchi Kuchibhotla, Hori, Satoshi, Khan, Shahid, Mohammud Inder, Shakeel, Sangaralingam, Shanthi, Marathe, Shekhar, Raveenthiran, Sheliyan, Horie, Shigeo, Sengupta, Shomik, Parson, Sian, Parker, Sidney, Hawlina, Simon, Williams, Simon, Mazzoli, Simone, Grzegorz Kata, Slawomir, Pinheiro Lopes, Sofia, Ramos, Sónia, Rai, Sonpreet, Rintoul-Hoad, Sophie, O'Meara, Sorcha, Morris, Steve, Turner, Stacey, Venturini, Stefano, Almpanis, Stephanos, Joniau, Steven, Jain, Sunjay, Mallett, Susan, Nikles, Sven, Shahzad, Yan, Sylvia, Lee, Taeweon, Uçar, Taha, Drake, Tamsin, Toma, Tarq, Cabañuz Plo, Teresa, Bonnin, Thierry, Muilwijk, Tim, Wollin, Tim, Chu, Timothy Shun Man, Appanna, Timson, Brophy, Tom, Ellul, Tom, Austin, Tomas, Smrkolj, Tomaž, Rowe, Tracey, Sukhu, Troy, Patel, Trushar, Garg, Tullika, Çaşkurlu, Turhan, Bele, Uros, Haroon, Usman, Crespo-Atín, Víctor, Parejo Cortes, Victor, Capapé Poves, Victoria, Gnanapragasam, Vincent, Gauhar, Vineet, During, Vinnie, Kumar, Vivek, Fiala, Vojtech, Mahmalji, Wasim, Lam, Wayne, Fung Chin, Yew, Filtekin, Yigit, Chyn Phan, Yih, Ibrahim, Youssed, Glaser, Zachary A, Abiddin, Zainal Adwin, Qin, Zijian, Zotter, Zsuzsanna, Zainuddin, Zulkifli, Khadhouri, Sinan, Gallagher, Kevin M., MacKenzie, Kenneth R., Shah, Taimur T., Gao, Chuanyu, Moore, Sacha, Zimmermann, Eleanor F., Edison, Eric, Jefferies, Matthew, Nambiar, Arjun, Anbarasan, Thineskrishna, Mannas, Miles P., Marra, Giancarlo, Gómez Rivas, Juan, Marcq, Gautier, Assmus, Mark A., Claps, Francesco, Boltri, Matteo, Burnhope, Tara, Nkwam, Nkwam, Boxall, Nicholas E., Downey, Alison P., Sukhu, Troy A., Chin, Yew-Fung, Green, James S.A., Goulao, Beatriz, Nielsen, Matthew, McGrath, John S., and Kasivisvanathan, Veeru

Published
2022
Full Text
View/download PDF

13. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author

Fabian, Ido Didi, Abdallah, Elhassan, Abdullahi, Shehu U, Abdulqader, Rula A, Abdulrahaman, Aminatu A, Abouelnaga, Sherif, Ademola-Popoola, Dupe S, Adio, Adedayo, Afifi, Mahmoud A, Afshar, Armin R, Aggarwal, Priyanka, Aghaji, Ada E, Ahmad, Alia, Akib, Marliyanti NR, Akinsete, Adeseye, Al Harby, Lamis, Al Mesfer, Saleh, Al Ani, Mouroge H, Alarcón Portabella, Silvia, Al-Badri, Safaa AF, Alcasabas, Ana Patricia A, Al-Dahmash, Saad A, Alejos, Amanda, Alemany-Rubio, Ernesto, Alfa Bio, Amadou I, Alfonso Carreras, Yvania, Al-Haddad, Christiane E, Al-Hussaini, Hamoud HY, Ali, Amany M, Alia, Donjeta B, Al-Jadiry, Mazin F, Al-Jumaily, Usama, Alkatan, Hind M, All-Eriksson, Charlotta, Al-Mafrachi, Ali ARM, Almeida, Argentino A, Alsawidi, Khalifa M, Al-Shaheen, Athar ASM, Al-Shammary, Entissar H, Amankwaa-Frempong, Doreen, Amiruddin, Primawita O, Armytasari, Inggar, Astbury, Nicholas J, Atalay, Hatice T, Ataseven, Eda, Atchaneeyasakul, La-ongsri, Atsiaya, Rose, Autrata, Rudolf, Balaguer, Julia, Balayeva, Ruhengiz, Barranco, Honorio, Bartoszek, Paulina, Bartuma, Katarina, Bascaran, Covadonga, Bechrakis, Nikolaos E, Beck Popovic, Maja, Begimkulova, Ainura S, Benmiloud, Sarra, Berete, Rokia C, Berry, Jesse L, Bhaduri, Anirban, Bhat, Sunil, Bhattacharyya, Arpita, Biewald, Eva M, Binkley, Elaine, Blum, Sharon, Bobrova, Nadia, Boldt, H.C., Bonanomi, Maria Teresa BC, Bouda, Gabrielle C, Bouguila, Hédi, Brennan, Rachel C, Brichard, Bénédicte G, Buaboonnam, Jassada, Budiongo, Aléine, Burton, Matthew J, Calderón-Sotelo, Patricia, Calle Jara, Doris A, Camuglia, Jayne E, Cano, Miriam R, Capra, Michael, Caspi, Shani, Cassoux, Nathalie, Castela, Guilherme, Castillo, Luis, Català-Mora, Jaume, Cavieres, Isabel, Chandramohan, Arthika, Chantada, Guillermo L, Chaudhry, Shabana, Chawla, Bhavna, Chen, Wensi, Chiwanga, Faraja S, Chuluunbat, Tsengelmaa, Cieslik, Krzysztof, Clark, Antony, Cockcroft, Ruellyn L, Comsa, Codruta, Correa Llano, Maria G, Corson, Timothy W, Couitchere, Line, Cowan-Lyn, Kristin E, Csóka, Monika, Dangboon, Wantanee, Das, Anirban, Das, Pranab, Das, Sima, Davanzo, Jacquelyn M, Davidson, Alan, De Francesco, Sonia, De Potter, Patrick, Quintero D, Karina, Demirci, Hakan, Desjardins, Laurence, Díaz Coronado, Rosdali Y, Dimaras, Helen, Dodgshun, Andrew J, Donato Macedo, Carla R, Dragomir, Monica D, Du, Yi, Du Bruyn, Magritha, Du Plessis, Johannes, Dudeja, Gagan, Eerme, Katrin, Eka Sutyawan, I Wayan, El Kettani, Asmaa, Elbahi, Amal M, Elder, James E, Elhaddad, Alaa M, Elhassan, Moawia MA, Elzembely, Mahmoud M, Ericksen, Connor, Essuman, Vera A, Evina, Ted Grimbert A, Ezegwui, Ifeoma R, Fadoo, Zehra, Fandiño, Adriana C, Faranoush, Mohammad, Fasina, Oluyemi, Fernández, Delia DPG, Fernández-Teijeiro, Ana, Foster, Allen, Frenkel, Shahar, Fu, Ligia D, Fuentes-Alabi, Soad L, Garcia, Juan L, García Aldana, David, Garcia Pacheco, Henry N, Geel, Jennifer A, Ghassemi, Fariba, Girón, Ana V, Goenz, Marco A, Gold, Aaron S, Goldberg, Hila, Gole, Glen A, Gomel, Nir, Gonzalez, Efren, Gonzalez Perez, Graciela, González-Rodríguez, Liudmira, Gorfine, Malka, Graells, Jaime, Gregersen, Pernille A, Grigorovski, Nathalia DAK, Guedenon, Koffi M, Gunasekera, D Sanjeeva, Gündüz, Ahmet K, Gupta, Himika, Gupta, Sanjiv, Gupta, Vineeta, Hadjistilianou, Theodora, Hamel, Patrick, Hamid, Syed A, Hamzah, Norhafizah, Hansen, Eric D, Harbour, J William, Hartnett, M. Elizabeth, Hasanreisoglu, Murat, Muhammad, Hassan, Hassan, Sadiq, Hassan, Shadab, Hautz, Wojciech, Haydar, Huda, Hederova, Stanislava, Hessissen, Laila, Hongeng, Suradej, Hordofa, Diriba F, Hubbard, G. Baker, Hummelen, Marlies, Husakova, Kristina, Hussein Al-Janabi, Allawi N, Ibanga, Affiong, Ida, Russo, Ilic, Vesna R, Islamov, Ziyavuddin, Jairaj, Vivekaraj, Janjua, Teyyeb, Jeeva, Irfan, Ji, Xunda, Jo, Dong Hyun, Jones, Michael M, Kabesha Amani, Theophile B, Kabore, Rolande L, Kaliki, Swathi, Kalinaki, Abubakar, Kamsang, Pius, Kantar, Mehmet, Kapelushnik, Noa, Kardava, Tamar, Kebudi, Rejin, Keomisy, Jonny, Kepak, Tomas, Ketteler, Petra, Khan, Zohora J, Khaqan, Hussain A, Khetan, Vikas, Khodabande, Alireza, Khotenashvili, Zaza, Kim, Jonathan W, Kim, Jeong Hun, Kiratli, Hayyam, Kivela, Tero T., Klett, Artur, Koç, Irem, Kosh Komba Palet, Jess Elio, Krivaitiene, Dalia, Kruger, Mariana, Kulvichit, Kittisak, Kuntorini, Mayasari W, Kyara, Alice, Lam, Geoffrey C, Larson, Scott A, Latinović, Slobodanka, Laurenti, Kelly D, Lavy, Yotam, Lavric Groznik, Alenka, Leverant, Amy A, Li, Cairui, Li, Kaijun, Limbu, Ben, Liu, Chun-Hsiu, Quah, BoonLong, López, Juan P, Lukamba, Robert M, Luna-Fineman, Sandra, Lutfi, Delfitri, Lysytsia, Lesia, Madgar, Shiran, Magrath, George N, Mahajan, Amita, Maitra, Puja, Maka, Erika, Makimbetov, Emil K, Maktabi, Azza, Maldonado, Carlos, Mallipatna, Ashwin, Manudhane, Rebecca, Manzhuova, Lyazat, Martín-Begue, Nieves, Masud, Sidra, Matende, Ibrahim O, Mattosinho, Clarissa CDS, Matua, Marchelo, Mayet, Ismail, Mbumba, Freddy B, McKenzie, John D, Mehrvar, Azim, Mengesha, Aemero A, Menon, Vikas, Mercado, Gary John V, Mets, Marilyn B, Midena, Edoardo, Miller, Audra, Mishra, Divyansh KC, Mndeme, Furahini G, Mohamedani, Ahmed A, Mohammad, Mona T, Moll, Annette C, Montero, Margarita M, Moreira, Claude, Mruthyunjaya, Prithvi, Msina, Mchikirwa S, Msukwa, Gerald, Mudaliar, Sangeeta S, Muma, Kangwa I M, Munier, Francis L, Murray, Timothy G, Musa, Kareem O, Mushtaq, Asma, Musika, Anne A, Mustak, Hamzah, Mustapha, Tajudeen, Muyen, Okwen M, Myezo, Khumo H, Naidu, Gita, Naidu, Natasha, Nair, Akshay Gopinathan, Natarajan, Sundaram, Naumenko, Larisa, Ndoye Roth, Paule Aïda, Nency, Yetty M, Neroev, Vladimir, Ng, Yvonne, Nikitovic, Marina, Nkanga, Elizabeth D, Nkumbe, Henry E, Numbi, Marcel N, Nummi, Kalle, Nuruddin, Murtuza, Nyaywa, Mutale, Nyirenda, Chinsisi, Obono-Obiang, Ghislaine, Oliver, Scott CN, Oporto, Joaquin, Ortega-Hernández, Miriam, Oscar, Alexander H, Ossandon, Diego, Pagarra, Halimah, Paintsil, Vivian, Paiva, Luisa, Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Parrozzani, Raffaele, Pascual Morales, Claudia R, Paton, Katherine E, Pe'er, Jacob, Peralta Calvo, Jesús, Perić, Sanja, Pham, Chau TM, Philbert, Remezo, Plager, David A, Pochop, Pavel, Polania, Rodrigo A., Polyakov, Vladimir, Ponce, Jimena, Qadir, Ali O, Qayyum, Seema, Qian, Jiang, Refaeli, David, Rahman, Ardizal, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Ramasubramanian, Aparna, Ramirez-Ortiz, Marco A, Randhawa, Jasmeen K, Randrianarisoa, Hoby Lalaina, Raobela, Léa, Rashid, Riffat, Reddy, M.A., Renner, Lorna A, Reynders, David, Ribadu, Dahiru, Ritter-Sovinz, Petra, Rogowska, Anna, Rojanaporn, Duangnate, Romero, Livia, Roy, Soma R, Saab, Raya H, Saakyan, Svetlana, Sabhan, Ahmed H, Sagoo, Mandeep S, Said, Azza MA, Saiju, Rohit, Salas, Beatriz, San Román Pacheco, Sonsoles, Sánchez, Gissela L, Sanchez Orozco, Alma Janeth, Sayalith, Phayvanh, Scanlan, Trish A, Schlüter, Sabrina, Schwab, Christoph, Sedaghat, Ahad, Seth, Rachna, Sgroi, Mariana, Shah, Ankoor S, Shakoor, Shawkat A, Sharma, Manoj K, Sherief, Sadik T, Shields, Carol L, Sia, David, Siddiqui, Sorath Noorani, Sidi cheikh, Sidi, Silva, Sónia, Singh, Arun D, Singh, Usha, Singha, Penny, Sitorus, Rita S, Skalet, Alison H, Soebagjo, Hendrian D, Sorochynska, Tetyana, Ssali, Grace, Stacey, Andrew W, Staffieri, Sandra E, Stahl, Erin D, Steinberg, David M, Stones, David K, Strahlendorf, Caron, Suarez, Maria Estela Coleoni, Sultana, Sadia, Sun, Xiantao, Superstein, Rosanne, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Svojgr, Karel, Sylla, Fatoumata, Tamamyan, Gevorg, Tan, Deborah, Tandili, Alketa, Tang, Jing, Tarrillo Leiva, Fanny F, Tashvighi, Maryam, Tateshi, Bekim, Teh, Kok Hoi, Tehuteru, Edi S, Teixeira, Luiz F, Tekavcic Pompe, Manca, Thawaba, Abdullah Dahan M, Theophile, Tuyisabe, Toledano, Helen, Trang, Doan L, Traoré, Fousseyni, Tripathy, Devjyoti, Tuncer, Samuray, Tyau-Tyau, Harba, Umar, Ali B, Unal, Emel, Uner, Ogul E, Urbak, Steen F, Ushakova, Tatiana L, Usmanov, Rustam H, Valeina, Sandra, Valente, Paola, van Hoefen Wijsard, Milo, Vasquez Anchaya, Jacqueline Karina, Vaughan, Leon O, Veleva-Krasteva, Nevyana V, Verma, Nishant, Victor, Andi A, Viksnins, Maris, Villacís Chafla, Edwin G, Villegas, Victor M, Vishnevskia-Dai, Victoria, Waddell, Keith, Wali, Amina H, Wang, Yi-Zhuo, Wangtiraumnuay, Nutsuchar, Wetter, Julie, Widiarti, Widiarti, Wilson, Matthew W, Wime, Amelia DC, Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wolley Dod, Charlotte, Wong, Emily S, Wongwai, Phanthipha, Wu, Si-qi, Xiang, Daoman, Xiao, Yishuang, Xu, Bing, Xue, Kang, Yaghy, Antonio, Yam, Jason C, Yang, Huasheng, Yanga, Jenny M, Yaqub, Muhammad A, Yarovaya, Vera A, Yarovoy, Andrey A, Ye, Huijing, Yee, Roberto I, Yousef, Yacoub A, Yuliawati, Putu, Zapata López, Arturo M, Zein, Ekhtelbenina, Zhang, Yi, Zhilyaeva, Katsiaryna, Zia, Nida, Ziko, Othman AO, Zondervan, Marcia, and Bowman, Richard

Published
2022
Full Text
View/download PDF

15. Medical students' perceptions towards international students, lecturers, and curriculum: Study report from a Malaysian private medical college.

Author

Mar, Saw Ohn, Malhi, Fatehpal Singh, Bilal, Hakim Gharib, Syed Hamid, Syed Rahim, and Ali, Osman

Subjects
STUDENT attitudes, FOREIGN study, PSYCHOLOGY of students, CULTURAL competence, MEDICAL students
Abstract

Background & Objective: Developing a global mindset and cultural competency is an important component of Internationalization in Medical Education (IoME) to prepare graduates ready to serve in interconnected global communities. To understand students' attitude towards IoME, this study explored their perceptions of international students, lecturers, and curriculum. Material & Methods: A cross-sectional study was conducted among medical students of the academic year 2018-2019 from University Kuala Lumpur, Royal College of Medicine Perak, Malaysia, using a self-administered validated questionnaire. All 569 students from years 1 to 5 were invited; out of 529 responses, 505 were eligible for analysis. Results: The vast majority (85.1%) of the respondents agreed that all medical schools should have international students. The combined ratings of "comfortable" and "very comfortable" with international students as classmates, as friends, and with international lecturers were 62.6%, 70.3%, and 66.7%, respectively. The transnational curriculum was selected as most appropriate by 45%. Good perception towards IoME was exhibited by 52.2% and was significantly associated with students' intention to do elective overseas among female (P = 0.002) and year 3 (P = 0.038) subgroups. Their perception was positively linked with their perceived preparedness to study or work overseas among females (P = 0.004). Conclusion: There is a positive association between the respondents' perceptions of IoME and their perceived readiness to study or work abroad more. Therefore, the design and implementation of curriculum should be in line with international standards to deliver both clinical and cultural competency that could be enhanced by race diversification among local students and having international students on campuses. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Functions of patient- and family-centered pediatric cancer communication in Pakistan.

Author

Graetz, Dylan E., Ahmad, Alia, Raza, Muhammad Rafie, Hameed, Ambreen, Naheed, Asma, Najmi, Atoofa, Quanita, Afia tul, Munir, Shabnam, Ahmad, Safwan, Ferrara, Gia, Staples, Courtney, Galindo, Carlos Rodriguez, Hamid, Syed Ahmer, Jeha, Sima, and Mack, Jennifer W.

Subjects
FAMILY-centered care, COMMUNICATION models, PEDIATRIC oncology, CHILDHOOD cancer, TRUST
Abstract

Background: Communication is an essential aspect of high-quality patient- and family-centered care. A model for pediatric cancer communication developed in the United States defined eight communication functions. The purpose of this study was to explore the relevance of these functions in Pakistan as part of an effort to understand the role of culture in communication. Materials and methods: Semi-structured interviews were conducted with 20 clinicians and 18 caregivers of children with cancer at two major cancer centers. Interviews were conducted in Urdu or English and transcribed and translated as necessary. Two independent coders used a priori codes related to the communication model as well as novel codes derived inductively. Thematic analysis focused on operationalization of the functional communication model. Results: Clinicians and caregivers in Pakistan discussed the importance of all eight communication functions previously identified including: information exchange, decision-making, managing uncertainty, enabling family selfmanagement, responding to emotions, supporting hope, providing validation, and building relationships. The operationalization of these functions was influenced by Pakistani cultural context. For example, information-exchange included the importance of addressing preconceptions and community myths, while managing uncertainty included strong references to religion and faithbased coping. Essential to all eight functions was trust between the family and the medical team. Discussion: These findings support the use of this functional communication model in diverse pediatric oncology settings and emphasize the importance of trust. Culturally sensitive operationalization of these functions could inform the adaptation of tools to measure communication and interventions aimed at supporting the needs of parents of children with cancer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Key Techniques and Challenges for Processing of Heart Sound Signals

Author

Shaikh Salleh, Sheikh Hussain, Noman, Fuad M., Chee-Ming, Ting, Syed Hamid, Syed Rasul Bin G., Hussain, Siti Hadrina Bt Sheikh, Jalil, M. A., Ahmad Zubaidi, A. L., Jacob, Kavikumar, Ray, Kanad, Kaiser, M. Shamim, Ali, Jalil, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Mahmud, Mufti, editor, Kaiser, M. Shamim, editor, Kasabov, Nikola, editor, Iftekharuddin, Khan, editor, and Zhong, Ning, editor

Published
2021
Full Text
View/download PDF

20. Improving Outcomes in Patients with Chronic Obstructive Pulmonary Disease after Hospitalization

Author

Isham, Brandi, Elkins, Casey, and Hamid, Syed

Subjects
Diseases -- Relapse, Hospital care -- Patient outcomes, Lung diseases, Obstructive -- Care and treatment -- Patient outcomes, Transitional care -- Methods -- Quality management, Health
Abstract

Patients with chronic obstructive pulmonary disorder (COPD) experience increased risk of readmission following hospitalization. A quality improvement project was implemented using a COPD bundle within a transitional care clinic to improve outcomes and reduce readmissions., Literature Summary * Despite multiple nationwide strategies, chronic obstructive pulmonary disorder (COPD) readmissions continue to remain problematic (Kong & Wilkinson, 2019). * Multiple studies have demonstrated decreased unplanned hospital visits [...]

Published
2022

21. Classification of ECG Ventricular Beats Assisted by Gaussian Parameters’ Dictionary

Author

Salleh, Sh Hussain, primary, Noman, Fuad, additional, Hussain, Hadri, additional, Ting, Chee-Ming, additional, Hamid, Syed Rasul bin G. Syed, additional, Sh-Hussain, Hadrina, additional, Jalil, M. A., additional, Zubaidi, A. L. Ahmad, additional, Rizvi, Syed Zuhaib Haider, additional, Kipli, Kuryati, additional, Jacob, Kavikumar, additional, Ray, Kanad, additional, Kaiser, M. Shamim, additional, Mahmud, Mufti, additional, and Ali, Jalil, additional

Published
2022
Full Text
View/download PDF

22. A Brief Review of Computation Techniques for ECG Signal Analysis

Author

Hussain, Salleh Sh, primary, Noman, Fuad, additional, Hussain, Hadri, additional, Ting, Chee-Ming, additional, bin Hamid, Syed Rasul G. Syed, additional, Sh-Hussain, Hadrina, additional, Jalil, M. A., additional, A.L., Ahmad Zubaidi, additional, Rizvi, Syed Zuhaib Haider, additional, Kipli, Kuryati, additional, Jacob, Kavikumar, additional, Ray, Kanad, additional, Shamim Kaiser, M., additional, Mahmud, Mufti, additional, and Ali, Jalil, additional

Published
2022
Full Text
View/download PDF

23. Targeting IRE1 with small molecules counteracts progression of atherosclerosis

Author

Tufanli, Ozlem, Telkoparan Akillilar, Pelin, Acosta-Alvear, Diego, Kocaturk, Begum, Onat, Umut Inci, Hamid, Syed Muhammad, Çimen, Ismail, Walter, Peter, Weber, Christian, and Erbay, Ebru

Subjects
Atherosclerosis, Aging, Cardiovascular, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Animals, Apolipoproteins E, Cells, Cultured, Disease Progression, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Homeostasis, Inflammasomes, Interleukin-18, Interleukin-1beta, Macrophages, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Protein Serine-Threonine Kinases, Signal Transduction, Small Molecule Libraries, Unfolded Protein Response, endoplasmic reticulum stress, unfolded protein response, metaflammation, lipotoxicity, atherosclerosis
Abstract

Metaflammation, an atypical, metabolically induced, chronic low-grade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent metabolic overloading of the endoplasmic reticulum (ER), leading to its functional impairment. Activation of the unfolded protein response (UPR), a homeostatic regulatory network that responds to ER stress, is a hallmark of all stages of atherosclerotic plaque formation. The most conserved ER-resident UPR regulator, the kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1), is activated in lipid-laden macrophages that infiltrate the atherosclerotic lesions. Using RNA sequencing in macrophages, we discovered that IRE1 regulates the expression of many proatherogenic genes, including several important cytokines and chemokines. We show that IRE1 inhibitors uncouple lipid-induced ER stress from inflammasome activation in both mouse and human macrophages. In vivo, these IRE1 inhibitors led to a significant decrease in hyperlipidemia-induced IL-1β and IL-18 production, lowered T-helper type-1 immune responses, and reduced atherosclerotic plaque size without altering the plasma lipid profiles in apolipoprotein E-deficient mice. These results show that pharmacologic modulation of IRE1 counteracts metaflammation and alleviates atherosclerosis.

Published
2017

25. Home or abroad? Exploring medical students' attitudes towards studying and working overseas.

Author

Saw Ohn Mar, Malhi, Fatehpal Singh, Bilal, Hakim Gharib, Syed Hamid, Syed Rahim, and Ali, Osman

Subjects
STUDENT attitudes, EMPLOYMENT in foreign countries, MEDICAL students, STUDENT mobility, RACE discrimination
Abstract

Background & Objective: Cross-border medical student mobility and doctor migration have become global trends. The aim of this study was to explore Malaysian medical students' attitudes towards studying and working overseas. Materials & Methods: A cross-sectional study was conducted among medical students of the academic year 2018-2019 from University Kuala Lumpur, Royal College of Medicine Perak, using a self-administered validated questionnaire that explored their opinions related to encouraging and deterring factors of studying and working overseas and their preferred destination for migration. All 569 students from years 1 to 5 were invited, and 505 completed responses were analyzed. Results: Financial factors were rated as most relevant for not studying overseas by 81.6% of the respondents, whereas language barriers and racial discrimination were considered less relevant. Doing electives overseas was favored by 68.9%. Regarding the benefits of further study abroad, learning international standards and experiencing diversity are rated as "very important" by 75.4% and 62.7%, respectively. They rated better earning (63.2%) and further learning (30.7%) as the most relevant reasons for doctors working overseas, and family commitment (49.9%), Medical Licensing Examinations (MLE) (38.4%), and loyalty to their home country (34.7%) for not working overseas. Their most preferred foreign destinations for further study and working are the UK, Ireland, and Australia. Conclusion: While appreciating the advantages of further study abroad, MLE was considered one of the deterring factors. As a result, consideration should be given to making changes to existing curricula to align with the expected standards of the destined countries. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Capacity building for pediatric neuro-oncology in Pakistan- a project by my child matters program of Foundation S

Author

Mushtaq, Naureen, primary, Qureshi, Bilal Mazhar, additional, Javed, Gohar, additional, Sheikh, Nabeel Ashfaque, additional, Bakhshi, Saqib Kamran, additional, Laghari, Altaf Ali, additional, Enam, Syed Ather, additional, Anwar, Shayan Sirat Maheen, additional, Hilal, Kiran, additional, Kabir, Arsalan, additional, Ahmad, Alia, additional, Goraya, Amber, additional, Mistry, Anum Salman, additional, Rashid, Aqeela, additional, Maaz, Ata Ur Rehman, additional, Munawar, Muhammad Atif, additional, Khan, Atiq Ahmed, additional, Bashir, Farrah, additional, Hashmi, Hina, additional, Saeed, Kamran, additional, Khandwala, Kumail, additional, Rehman, Lal, additional, Dewan, Michael C., additional, Khan, Muhammad Saghir, additional, Karim, Muneeb uddin, additional, Shaheen, Najma, additional, Zia, Nida, additional, Yasmeen, Nuzhat, additional, Mahmood, Raheela, additional, Memon, Riaz Ahmed Raja, additional, Kirmani, Salman, additional, Resham, Shahzadi, additional, Kadri, Shazia, additional, Riaz, Shazia, additional, Hamid, Syed Ahmer, additional, Ghafoor, Tariq, additional, Imam, Uzma, additional, Mushtaq, Yaseen Rauf, additional, Rana, Zulfiqar Ali, additional, Bouffet, Eric, additional, and Minhas, Khurram, additional

Published
2024
Full Text
View/download PDF

27. Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns

Author

Dodgshun, Andrew J., Fukuoka, Kohei, Edwards, Melissa, Bianchi, Vanessa J., Das, Anirban, Sexton-Oates, Alexandra, Larouche, Valérie, Vanan, Magimairajan I., Lindhorst, Scott, Yalon, Michal, Mason, Gary, Crooks, Bruce, Constantini, Shlomi, Massimino, Maura, Chiaravalli, Stefano, Ramdas, Jagadeesh, Mason, Warren, Ashraf, Shamvil, Farah, Roula, Van Damme, An, Opocher, Enrico, Hamid, Syed Ahmer, Ziegler, David S., Samuel, David, Cole, Kristina A., Tomboc, Patrick, Stearns, Duncan, Thomas, Gregory A., Lossos, Alexander, Sullivan, Michael, Hansford, Jordan R., Mackay, Alan, Jones, Chris, Jones, David T. W., Ramaswamy, Vijay, Hawkins, Cynthia, Bouffet, Eric, and Tabori, Uri

Published
2020
Full Text
View/download PDF

29. Key Techniques and Challenges for Processing of Heart Sound Signals

Author

Shaikh Salleh, Sheikh Hussain, primary, Noman, Fuad M., additional, Chee-Ming, Ting, additional, Syed Hamid, Syed Rasul Bin G., additional, Hussain, Siti Hadrina Bt Sheikh, additional, Jalil, M. A., additional, Ahmad Zubaidi, A. L., additional, Jacob, Kavikumar, additional, Ray, Kanad, additional, Kaiser, M. Shamim, additional, and Ali, Jalil, additional

Published
2021
Full Text
View/download PDF

35. Retinoblastoma in Asia: Clinical presentation and Treatment Outcomes in 2112 patients from 33 countries

Author

Kaliki, Swathi, primary, Vempuluru, Vijitha S., additional, Mohamed, Ashik, additional, Al-Jadiry, Mazin Faisal, additional, Bowman, Richard, additional, Chawla, Bhavna, additional, Hamid, Syed Ahmer, additional, Ji, Xunda, additional, Kapelushnik, Noa, additional, Kebudi, Rejin, additional, Sthapit, Purnima Rajkarnikar, additional, Rojanaporn, Duangnate, additional, Sitorus, Rita S., additional, Yousef, Yacoub Abdallah, additional, and Fabian, Ido Didi, additional

Published
2023
Full Text
View/download PDF

36. Barriers and Facilitators of Quality Family-Centered Communication in Pakistan

Author

Graetz, Dylan, primary, Ahmad, Alia, additional, Raza, Muhammad Rafie, additional, Hameed, Ambreen, additional, Naheed, Asma, additional, Najmi, Atoofa, additional, tul Quanita, Afia, additional, Munir, Shabnam, additional, Ferrara, Gia, additional, Staples, Courtney, additional, Rodriguez Galindo, Carlos, additional, Hamid, Syed Ahmer, additional, Jeha, Sima, additional, and Mack, Jennifer W., additional

Published
2023
Full Text
View/download PDF

41. Impact of alternative Non-Pharmaceutical Interventions strategies for controlling COVID-19 outbreak in Bangladesh: A modeling study.

Author

Shimul, Shafiun Nahin, Hussain, Mofakhar, Faisel, Abul Jamil, Hamid, Syed Abdul, Sultana, Nasrin, and Kuddus, Md Abdul

Subjects
COVID-19 pandemic, COVID-19, SCHOOL closings, HAND washing, MIDDLE-income countries, DEATH forecasting
Abstract

The COVID-19 pandemic has been a major health concern in Bangladesh until very recently. Although the Bangladesh government has employed various infection control strategies, more targeted Non-Pharmaceutical interventions (NPIs), including school closure, mask-wearing, hand washing, and social distancing have gained special attention. Despite significant long-term adverse effects of school closures, authorities have opted to keep schools closed to curb the spread of COVID-19 infection. However, there is limited knowledge about the impact of reopening schools alongside other NPI measures on the course of the epidemic. In this study, we implemented a mathematical modeling framework developed by the CoMo Consortium to explore the impact of NPIs on the dynamics of the COVID-19 outbreak and deaths for Bangladesh. For robustness, the results of prediction models are then validated through model calibration with incidence and mortality data and using external sources. Hypothetical projections are made under alternative NPIs where we compare the impact of current NPIs with school closures versus enhanced NPIs with school openings. Results suggest that enhanced NPIs with schools opened may have lower COVID-19 related prevalence and deaths. This finding indicates that enhanced NPIs and school openings may mitigate the long-term negative impacts of COVID-19 in low- and middle-income countries. Potential shortcomings and ways to improve the research are also discussed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

42. Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches.

Author

Mushtaq, Naureen, Ul Ain, Rahat, Hamid, Syed Ahmer, and Bouffet, Eric

Subjects
MEDULLOBLASTOMA, MOLECULAR biology
Abstract

The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

43. Alpha-mannosidosis: a case with novel ultrastructural and light microscopy findings.

Author

Leong, Matthew, Sathi, Bindu, Davis, Amy, Hamid, Syed, Wu, Sandy, Woods, Jeremy, Kharbanda, Sandhya, Li, Xiaomo, and Hou, Jean

Abstract

Alpha-mannosidosis is a rare genetic lysosomal storage condition leading to the systemic buildup of oligomannoside. Clinical presentation and associated conditions, as well as the full extent of histopathologic changes associated with this disease process, are not fully understood. We present the case of an 8-year-1-month old patient with persistent anemia and who was initially diagnosed with Celiac disease before ultimately being diagnosed with alpha-mannosidosis. As part of his diagnostic work-up, duodenal and bone marrow biopsies were examined by pathology. Duodenal biopsies showed foamy plasma cells expanding the lamina propria which triggered a workup for a genetic storage disease; features suggestive of Celiac disease which resolved on gluten-free diet were also noted by pathology. Bone marrow analysis via electron microscopy showed cytoplasmic granules and inclusions in multiple immune cell lines. Alpha-mannosidosis can occur with Celiac disease and milder forms may only be suspected from incidental pathology findings. The ultrastructural bone marrow findings from this case, the first to be reported from human, show numerous disease-associated changes in multiple immune cell lines whose contribution to disease-associated immunodeficiency is unclear. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

47. Alveolar Type 1 Epithelial Cell Deficiency in Pulmonary Hypertension

Author

Hamid, Syed and Hamid, Syed

Abstract

Rationale: Pulmonary Arterial Hypertension (PAH) is a severe health condition that involvesan ongoing process of pulmonary vascular resistance and vascular remodeling. These changes can eventually cause right heart failure (RHF) and in severe cases and can eventually result in death. AT1 cells mediate gas exchange in the lung. However, the connection between AT1 cell dysfunction and the onset of pulmonary hypertension (PH) is still not well-understood. A better understanding of the mechanisms could help the improvement of treatment for PAH. Objectives: To investigate the role and underlying mechanisms of AT1 cell deficiency in the pathogenesis of PAH. Methods: To determine whether AT1 cells are deficient in the development of PAH, lung sections from idiopathic PAH (IPAH) and control donors, as well as lung tissues from PH mice model Egln1Tie2cre (CKO) mice and wild-type (WT) mice, were evaluated for the expression of AT1 cell markers. Reverse Transcription-quantitative PCR (RT-qPCR) was performed in mice samples, to determine the expression levels of AT1 cells markers (Ager, Aqp5, Hopx, Rtkn2) using lung tissues from CKO and WT mice. Western blot analysis was then performed to quantitatively evaluate AT1 cell marker protein levels (Ager, Hopx) in lungs from CKO and WT mice. Immunofluorescence staining was applied using HOPX in both mice lungs and human IPAH lungs. Additionally, the expression of VEGFA, AT1 derived factor, was determined using the RNAscope technique on human IPAH and control lungs. Results: The findings of this study showed the mRNA levels of AT1 markers including Hopx and Rtkn2 were downregulated in CKO mice. The expression levels of AT1 markers Ager but not Hopx was downregulated in CKO mice by Western Blot. A decrease of AT1 cells assessed by quantification of HOPX in the IPAH human samples and CKO mice was observed in Immunofluorescent staining. Lastly, upregulated VEGFA expression in IPAH human samples were recorded as revealed by the RNA scope.

Published
2023

48. Exploring the Nexus "between" "Corporate Social Responsibility" Persuasion and "Organizational Citizenship Behavior": Evidence from Public Sector Employees.

Author

Raza, Syed Saqlain, Hamid, Syed Ali Raza, and Ghani, Usman

Subjects
ORGANIZATIONAL citizenship behavior, SOCIAL responsibility of business, PUBLIC sector, CIVIL service, ALTRUISM, PERSUASION (Psychology)
Abstract

Corporate Social Responsibility (CSR)" has become a focal point of interest in contemporary times. While much research has focused on the impact of "CSR" on consumers, there remains a gap in understanding its effects on Organizational Citizenship Behavior (OCB) amongst public sector employees. This study examines how "Employees' CSR persuasion (ECP)" influences job felicity and Responsive Assurance (RA) on "OCB" in the public sector. By considering the four dimensions of CSR--economic, legal, ethical, and philanthropic--we explore the relationships amongst ECP, job felicity, RA, and OCB. Many countries are implementing public sector reforms to enhance government employees' OCB, which is vital for program success. We categorize "citizenship behavior" into "altruism, conscientiousness, courtesy, civic virtue", and "sportsmanship". Our findings indicate a positive link between ECP and OCB (B=0.199, p<0.01), a negative association with External Job Felicity (EJF) (B=-0.412, p<0.01), and a substantial negative impact of EJF on OCB (B=-0.158, p<0.01). Additionally, RA (B=0.274, p<0.01) and Inbuilt Job Felicity (IJF) (B=0.261, p<0.01) are positively and significantly related to OCB amongst public sector employees in Pakistan. These results highlight the importance of CSR initiatives for public sector employees, as they have the potential to promote positive workplace behaviors. [ABSTRACT FROM AUTHOR]

Published
2023

49. The Clinical and Biological Landscape of Constitutional Mismatch Repair Deficiency: An IRRDC Study

Author

Ercan, Ayse Bahar, primary, Aronson, Melyssa, additional, Fernandez, Nicholas R., additional, Chang, Yuan, additional, Levine, Adrian, additional, Liu, Amy Zhihui, additional, Negm, Logine, additional, Edwards, Melissa, additional, Bianchi, Vanessa, additional, Stengs, Lucie, additional, Chung, Brian, additional, Al-Battashi, Abeer, additional, Reschke, Agnes, additional, Lion, Alex, additional, Ahmad, Alia, additional, Lassaletta, Alvaro, additional, Reddy, Alyssa, additional, Al-Darraji, Amir Fadhil, additional, Shah, Amish C., additional, Van Damme, An, additional, Bendel, Anne E., additional, Rashid, Aqeela, additional, Margol, Ashley S., additional, Kelly, Bethany L., additional, Pencheva, Bojana, additional, Heald, Brandie, additional, Anglin, Brianna Lemieux, additional, Crooks, Bruce, additional, Koschmann, Carl, additional, Gilpin, Catherine, additional, Porter, Christopher C., additional, Gass, David, additional, Samuel, David, additional, Ziegler, David S., additional, Blumenthal, Deborah T., additional, Kuo, Dennis John, additional, Hamideh, Dima, additional, Basel, Donald, additional, Khuong Quang, Dong Anh, additional, Stearns, Duncan, additional, Opocher, Enrico, additional, Carcellar, Fernando, additional, Feldman, Hagit Baris, additional, Toledano, Helen, additional, Winer, Ira S., additional, Scheers, Isabelle, additional, Fedorakova, Ivana, additional, Su, Jack M., additional, Barrios, Jaime Vengoechea, additional, Sterba, Jaroslav, additional, Knipstein, Jeffrey, additional, Hansford, Jordan R., additional, Gonzales-Santos, Julieta Rita, additional, Bhatia, Kanika, additional, Bielamowicz, Kevin J., additional, Minhas, Khurram, additional, Nichols, Kim E., additional, Cole, Kristina A., additional, Penney, Lynette, additional, Hjort, Magnus Aasved, additional, Sabel, Magnus, additional, Gil-da-Costa, Maria Joao, additional, Murray, Matthew J., additional, Miller, Matthew, additional, Blundell, Maude, additional, Massimino, Maura, additional, Al-Hussaini, Maysa, additional, Al-Jadiry, Mazin Faisal, additional, Comito, Melanie A., additional, Osborn, Michael, additional, Link, Michael P., additional, Zapotocky, Michal, additional, Ghalibafian, Mithra, additional, Shaheen, Najma, additional, Mushtaq, Naureen, additional, Waespe, Nicolas, additional, Hijiya, Nobuko, additional, Fuentes Bolanos, Noemi, additional, Ahmad, Olfat, additional, Chamdine, Omar, additional, Roy, Paromita, additional, Pichurin, Pavel N., additional, Nymen, Per, additional, Pearlman, Rachel, additional, Auer, Rebecca C., additional, Sukumaran, Reghu K., additional, Kebudi, Rejin, additional, Dvir, Rina, additional, Raphael, Robert, additional, Elhasid, Ronit, additional, McGee, Rose B., additional, Chami, Rose, additional, Noss, Ryan, additional, Tanaka, Ryuma, additional, Raskin, Salmo, additional, Sen, Santanu, additional, Lindhorst, Scott, additional, Perreault, Sebastian, additional, Caspi, Shani, additional, Riaz, Shazia, additional, Constantini, Shlomi, additional, Albert, Sophie, additional, Chaleff, Stanley, additional, Bielack, Stefan S., additional, Chiaravalli, Stefano, additional, Cramer, Stuart Louis, additional, Roy, Sumita, additional, Cahn, Suzanne, additional, Penna, Suzanne, additional, Hamid, Syed Ahmer, additional, Ghafoor, Tariq, additional, Imam, Uzma, additional, Larouche, Valerie, additional, MagimairajanIssai, Vanan, additional, Foulkes, William, additional, Lee, Yi Yen, additional, Maruvka, Yosef E., additional, Greer, Mary-Louise C., additional, Durno, Carol, additional, Shlien, Adam, additional, Ertl-Wagner, Birgit, additional, Villani, Anita, additional, Malkin, David, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, Das, Anirban, additional, and Tabori, Uri, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results