35 results on '"Hamer, P.C."'
Search Results
2. Cannabinoids to Improve Health-Related Quality of Life in Patients with Neurological or Oncological Disease: A Meta-Analysis.
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Belgers, V., Röttgering, J.G., Douw, L., Klein, Martin, Ket, J.C., Ven, P.M. van de, Würdinger, T., Linde, M.E. van, Niers, J.M., Weber, M., Olde Rikkert, M.G.M., Lopez-Sendon, J., Arrieta, O., Svendsen, K.B., Chagas, M.H.N., Almeida, C.M.O. de, Kouwenhoven, M.C., Witt Hamer, P.C. de, Belgers, V., Röttgering, J.G., Douw, L., Klein, Martin, Ket, J.C., Ven, P.M. van de, Würdinger, T., Linde, M.E. van, Niers, J.M., Weber, M., Olde Rikkert, M.G.M., Lopez-Sendon, J., Arrieta, O., Svendsen, K.B., Chagas, M.H.N., Almeida, C.M.O. de, Kouwenhoven, M.C., and Witt Hamer, P.C. de
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01 februari 2023, Item does not contain fulltext, Background: Cannabinoids have been suggested to alleviate frequently experienced symptoms of reduced mental well-being such as anxiety and depression. Mental well-being is an important subdomain of health-related quality of life (HRQoL). Reducing symptoms and maintaining HRQoL are particularly important in malignant primary brain tumor patients, as treatment options are often noncurative and prognosis remains poor. These patients frequently report unprescribed cannabinoid use, presumably for symptom relieve. As studies on brain tumor patients specifically are lacking, we performed a meta-analysis of the current evidence on cannabinoid efficacy on HRQoL and mental well-being in oncological and neurological patients. Methods: We performed a systematic PubMed, PsychINFO, Embase, and Web of Science search according to PRISMA guidelines on August 2 and 3, 2021. We included randomized controlled trials (RCTs) that assessed the effects of tetrahydrocannabinol (THC) or cannabidiol (CBD) on general HRQoL and mental well-being. Pooled effect sizes were calculated using Hedges g. Risk of bias of included studies was assessed using Cochrane's Risk of Bias tool. Results: We included 17 studies: 4 in oncology and 13 in central nervous system (CNS) disease. Meta-analysis showed no effect of cannabinoids on general HRQoL (g=-0.02 confidence interval [95% CI -0.11 to 0.06]; p=0.57) or mental well-being (g=-0.02 [95% CI -0.16 to 0.13]; p=0.81). Conclusions: RCTs in patients with cancer or CNS disease showed no effect of cannabinoids on HRQoL or mental well-being. However, studies were clinically heterogeneous and since many glioma patients currently frequently use cannabinoids, future studies are necessary to evaluate its value in this specific population.
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- 2023
3. The Aftercare Survey: Assessment and intervention practices after brain tumor surgery in Europe
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Sierpowska, J.M., Rofes, A., Dahlslätt, K.P.G., Mandonnet, E., Laan, M. ter, Polczynska, M., De Witt Hamer, P.C., Halaj, M., Spena, G., Meling, T.R., Motomura, K., Reyes, A.F., Campos, A.R., Robe, P.A.J.T., Zigiotto, L., Freyschlag, C.F., Broen, M.P.G., Sarubbo, S., Stranjalis, G., Papadopoulos, K., liouta, E., Rutten, G.J., Viegas, C.P., Silvestre, A., Perrote, F., Brochero, N., Cáceres, C., Zdun-Ryzewska, A., Kloc, W., Satoer, D., Dragoy, O., Hendriks, M.P.H., Alvarez-Carriles, J.C., Piai, V., Sierpowska, J.M., Rofes, A., Dahlslätt, K.P.G., Mandonnet, E., Laan, M. ter, Polczynska, M., De Witt Hamer, P.C., Halaj, M., Spena, G., Meling, T.R., Motomura, K., Reyes, A.F., Campos, A.R., Robe, P.A.J.T., Zigiotto, L., Freyschlag, C.F., Broen, M.P.G., Sarubbo, S., Stranjalis, G., Papadopoulos, K., liouta, E., Rutten, G.J., Viegas, C.P., Silvestre, A., Perrote, F., Brochero, N., Cáceres, C., Zdun-Ryzewska, A., Kloc, W., Satoer, D., Dragoy, O., Hendriks, M.P.H., Alvarez-Carriles, J.C., and Piai, V.
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04 april 2022, Item does not contain fulltext, People with gliomas need specialized neurosurgical, neuro-oncological, psycho-oncological, and neuropsychological care. The role of language and cognitive recovery and rehabilitation in patients’ well-being and resumption of work is crucial, but there are no clear guidelines for the ideal timing and character of assessments and interventions. The goal of the present work was to describe representative (neuro)psychological practices implemented after brain surgery in Europe.An online survey was addressed to professionals working with individuals after brain surgery. We inquired about the assessments and interventions and the involvement of caregivers. Additionally, we asked about recommendations for an ideal assessment and intervention plan.Thirty-eight European centers completed the survey. Thirty of them offered at least one postsurgical (neuro)psychological assessment, mainly for language and cognition, especially during the early recovery stage and at long term. Twenty-eight of the participating centers offered postsurgical therapies. Patients who stand the highest chances of being included in evaluation and therapy postsurgically are those who underwent awake brain surgery, harbored a low-grade glioma, or showed poor recovery. Nearly half of the respondents offer support programs to caregivers, and all teams recommend them. Treatments differed between those offered to individuals with low-grade glioma vs those with high-grade glioma. The figure of caregiver is not yet fully recognized in the recovery phase.We stress the need for more complete rehabilitation plans, including the emotional and health-related aspects of recovery. In respondents’ opinions, assessment and rehabilitation plans should also be individually tailored and goal-directed (eg, professional reinsertion).
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- 2022
4. Detection and localization of early- and late-stage cancers using platelet RNA
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Veld, S., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D.C.L., Vermunt, L., Vancura, A., Muller, Mirte, Niemeijer, A.N., Tannous, J., Meijer, L.L., Large, T.Y. Le, Mantini, G., Wondergem, N.E., Heinhuis, K.M., Wilpe, S. van, Smits, Josien, Drees, E.E.E., Roos, E., Leurs, C.E., Fat, L.A. Tjon Kon, Lelij, E.J. van der, Dwarshuis, G., Kamphuis, M.J., Visser, Leonie N.C., Harting, R., Gregory, A., Schweiger, M.W., Wedekind, L.E., Ramaker, J., Zwaan, K., Verschueren, H., Bahce, I, Langen, A.J. de, Smit, E.F., Heuvel, M.M. van den, Hartemink, K.J., Kuijpers, M.J., Egbrink, M.G.A. Oude, Griffioen, A.W., Rossel, R., Hiltermann, T.J.N., Lee-Lewandrowski, E., Lewandrowski, K.B., Hamer, P.C., Kouwenhoven, M., Reijneveld, J.C., Leenders, W.P.J., Hoeben, A., Verdonck-de Leeuw, I.M., Leemans, C.Rene, Baatenburg de Jong, R.J., Terhaard, Chris H. J., Takes, R.P., Langendijk, J.A., Jager, S.C. de, Kraaijeveld, A.O., Pasterkamp, G., Smits, M., Schalken, J.A., Łapińska-Szumczyk, S., Łojkowska, A., Żaczek, A.J., Lokhorst, H., Donk, N. van de, Nijhof, I., Prins, H.J., Zijlstra, J.M., Idema, S., Baayen, J.C., Teunissen, C.E., Killestein, J., Besselink, M.G.H., Brammen, L., Bachleitner-Hofmann, T., Mateen, F., Plukker, J.T., Heger, M., Mast, Q. de, Lisman, T., Pegtel, D.M., Bogaard, H.J., Jassem, J., Supernat, A., Mehra, N., Gerritsen, W.R., Kroon, C.D. de, Lok, C. A. R., Piek, J.M.J., Steeghs, N., Houdt, W.J. van, Brakenhoff, R.H., Sonke, G.S., Verheul, H.M.W., Giovannetti, E., Kazemier, G., Sabrkhany, S., Schuuring, E., Sistermans, E.A., Veld, S., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D.C.L., Vermunt, L., Vancura, A., Muller, Mirte, Niemeijer, A.N., Tannous, J., Meijer, L.L., Large, T.Y. Le, Mantini, G., Wondergem, N.E., Heinhuis, K.M., Wilpe, S. van, Smits, Josien, Drees, E.E.E., Roos, E., Leurs, C.E., Fat, L.A. Tjon Kon, Lelij, E.J. van der, Dwarshuis, G., Kamphuis, M.J., Visser, Leonie N.C., Harting, R., Gregory, A., Schweiger, M.W., Wedekind, L.E., Ramaker, J., Zwaan, K., Verschueren, H., Bahce, I, Langen, A.J. de, Smit, E.F., Heuvel, M.M. van den, Hartemink, K.J., Kuijpers, M.J., Egbrink, M.G.A. Oude, Griffioen, A.W., Rossel, R., Hiltermann, T.J.N., Lee-Lewandrowski, E., Lewandrowski, K.B., Hamer, P.C., Kouwenhoven, M., Reijneveld, J.C., Leenders, W.P.J., Hoeben, A., Verdonck-de Leeuw, I.M., Leemans, C.Rene, Baatenburg de Jong, R.J., Terhaard, Chris H. J., Takes, R.P., Langendijk, J.A., Jager, S.C. de, Kraaijeveld, A.O., Pasterkamp, G., Smits, M., Schalken, J.A., Łapińska-Szumczyk, S., Łojkowska, A., Żaczek, A.J., Lokhorst, H., Donk, N. van de, Nijhof, I., Prins, H.J., Zijlstra, J.M., Idema, S., Baayen, J.C., Teunissen, C.E., Killestein, J., Besselink, M.G.H., Brammen, L., Bachleitner-Hofmann, T., Mateen, F., Plukker, J.T., Heger, M., Mast, Q. de, Lisman, T., Pegtel, D.M., Bogaard, H.J., Jassem, J., Supernat, A., Mehra, N., Gerritsen, W.R., Kroon, C.D. de, Lok, C. A. R., Piek, J.M.J., Steeghs, N., Houdt, W.J. van, Brakenhoff, R.H., Sonke, G.S., Verheul, H.M.W., Giovannetti, E., Kazemier, G., Sabrkhany, S., Schuuring, E., and Sistermans, E.A.
- Abstract
Contains fulltext : 281792.pdf (Publisher’s version ) (Open Access), Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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- 2022
5. Glioma perfusion quantification with ASL and DSC: head-to-head comparison with 15O-H2O PET
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Petr, J., additional, Verburg, N., additional, Kuijer, J., additional, Koopman, T., additional, Keil, V.C., additional, Warnert, E.A., additional, Barkhof, F., additional, van den Hoff, J., additional, Boellaard, R., additional, de Witt Hamer, P.C., additional, and Mutsaerts, H.J., additional
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- 2022
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6. Between‐hospital variation in rates of complications and decline of patient performance after glioblastoma surgery in the dutch Quality Registry Neuro Surgery
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Kommers, I. (Ivar), Ackermans, L. (Linda), Ardon, H. (Hilko), Brink, W. (Wimar) van den, Bouwknegt, W. (Wim), Balvers, R.K. (Rutger), Gaag, N.A. (Niels) van der, Bosscher, L. (Lisette), Kloet, A. (Alfred), Koopmans, J. (Jan), Laan, M. (Mark ter), Tewarie, R.N. (Rishi Nandoe), Robe, P.A. (Pierre A.), van der Veer, O. (Olivier), Wagemakers, M. (Michiel), Zwinderman, A.H. (Ailko), De Witt Hamer, P.C. (Philip C.), Kommers, I. (Ivar), Ackermans, L. (Linda), Ardon, H. (Hilko), Brink, W. (Wimar) van den, Bouwknegt, W. (Wim), Balvers, R.K. (Rutger), Gaag, N.A. (Niels) van der, Bosscher, L. (Lisette), Kloet, A. (Alfred), Koopmans, J. (Jan), Laan, M. (Mark ter), Tewarie, R.N. (Rishi Nandoe), Robe, P.A. (Pierre A.), van der Veer, O. (Olivier), Wagemakers, M. (Michiel), Zwinderman, A.H. (Ailko), and De Witt Hamer, P.C. (Philip C.)
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Introduction: For decisions on glioblastoma surgery, the risk of complications and decline in performance is decisive. In this study, we determine the rate of complications and performance decline after resections and biopsies in a national quality registry, their risk factors and the risk-standardized variation between institutions. Methods: Data from all 3288 adults with first-time glioblastoma surgery at 13 hospitals were obtained from a prospective population-based Quality Registry Neuro Surgery in the Netherlands between 2013 and 2017. Patients were stratified by biopsies and resections. Complications were categorized as Clavien-Dindo grades II and higher. Performance decline was considered a deterioration of more than 10 Karnofsky points at 6 weeks. Risk factors were evaluated in multivariable logistic regression analysis. Patient-specific expected and observed complications and performance declines were summarized for institutions and analyzed in funnel plots. Results: For 2271 resections, the overall complication rate was 20 % and 16 % declined in performance. For 1017 biopsies, the overall complication rate was 11 % and 30 % declined in performance. Patient-related characteristics were significant risk factors for complications and performance decline, i.e. higher age, lower baseline Karnofsky, higher ASA classification, and the surgical procedure. Hospital characteristics, i.e. case volume, university affiliation and biopsy percentage, were not. In three institutes the observed complication rate was significantly less than expected. In one institute significantly more performance declines were observed than expected, and in one institute significantly less. Conclusions: Patient characteristics, but not case volume, were risk factors for complications and performance decline after glioblastoma surgery. After risk-standardization, hospitals varied in complications and performance declines.
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- 2021
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7. Non-invasively measured brain activity and radiological progression in diffuse glioma
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Numan, T., primary, Kulik, S.D., additional, Moraal, B., additional, Reijneveld, J.C., additional, Stam, CJ., additional, de Witt Hamer, P.C., additional, Derks, J., additional, Bruynzeel, A.M.E., additional, van Linde, M.E., additional, Wesseling, P., additional, Kouwenhoven, M.C.M., additional, Klein, M., additional, Würdinger, T., additional, Barkhof, F., additional, Geurts, J.J.G., additional, Hillebrand, A., additional, and Douw, L., additional
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- 2021
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8. Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma
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Sol, N., Veld, S., Vancura, A., Tjerkstra, M., Leurs, C., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Zwaan, K., Ramaker, J., Wedekind, L.E., Tannous, J., Ylstra, B., Killestein, J., Mateen, F., Idema, S., Hamer, P.C., Navis, A.C., Leenders, W.P.J., Hoeben, A., Moraal, B., Noske, D.P., Vandertop, W.P., Nilsson, R.J., Tannous, B.A., Wesseling, P., Reijneveld, J.C., Best, M.G., Wurdinger, T., Sol, N., Veld, S., Vancura, A., Tjerkstra, M., Leurs, C., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Zwaan, K., Ramaker, J., Wedekind, L.E., Tannous, J., Ylstra, B., Killestein, J., Mateen, F., Idema, S., Hamer, P.C., Navis, A.C., Leenders, W.P.J., Hoeben, A., Moraal, B., Noske, D.P., Vandertop, W.P., Nilsson, R.J., Tannous, B.A., Wesseling, P., Reijneveld, J.C., Best, M.G., and Wurdinger, T.
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Contains fulltext : 229052.pdf (publisher's version ) (Open Access), Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA profile of TEPs from glioblastoma patients with multiple sclerosis and brain metastasis patients (validation series, n = 157; accuracy, 80%; AUC, 0.81 [95% CI, 0.74-0.89; p < 0.001]). Second, analysis of patients with glioblastoma versus asymptomatic healthy controls in an independent validation series (n = 347) provided a detection accuracy of 95% and AUC of 0.97 (95% CI, 0.95-0.99; p < 0.001). Finally, we developed the digitalSWARM algorithm to improve monitoring of glioblastoma progression and demonstrate that the TEP tumor scores of individual glioblastoma patients represent tumor behavior and could be used to distinguish false positive progression from true progression (validation series, n = 20; accuracy, 85%; AUC, 0.86 [95% CI, 0.70-1.00; p < 0.012]). In conclusion, TEPs have potential as a minimally invasive biosource for blood-based diagnostics and monitoring of glioblastoma patients.
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- 2020
9. DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity
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Verburg, N., primary, Barthel, F.B., additional, Anderson, K.J., additional, Johnson, K.C., additional, Koopman, T., additional, Yaqub, M.M., additional, Hoekstra, O.S., additional, Lammertsma, A.A., additional, Barkhof, F., additional, Pouwels, P.J.W., additional, Reijneveld, J.C., additional, Rozemuller, A.J.M., additional, Boellaard, R., additional, Taylor, M.D., additional, Das, S., additional, Costello, J.F., additional, Vandertop, W.P., additional, Wesseling, P., additional, de Witt Hamer, P.C., additional, and Verhaak, R.G.W., additional
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- 2020
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10. Between-hospital variation in mortality and survival after glioblastoma surgery in the Dutch Quality Registry for Neuro Surgery
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De Witt Hamer, P.C. (Philip C.), Ho, V.K.Y. (Vincent), Zwinderman, A.H. (Ailko), Ackermans, L. (Linda), Ardon, H. (Hilko), Boomstra, S. (Sytske), Bouwknegt, W. (Wim), van den Brink, W.A. (Wimar A.), Dirven, C.M.F. (Clemens), van der Gaag, N.A. (Niels A.), van der Veer, O. (Olivier), Idema, A.J.S. (Albert J. S.), Kloet, A. (Alfred), Koopmans, J. (Jan), ter Laan, M. (Mark), Verstegen, M.J.T. (Marco), Wagemakers, M. (Michiel), Robe, P.A. (Pierre A.), De Witt Hamer, P.C. (Philip C.), Ho, V.K.Y. (Vincent), Zwinderman, A.H. (Ailko), Ackermans, L. (Linda), Ardon, H. (Hilko), Boomstra, S. (Sytske), Bouwknegt, W. (Wim), van den Brink, W.A. (Wimar A.), Dirven, C.M.F. (Clemens), van der Gaag, N.A. (Niels A.), van der Veer, O. (Olivier), Idema, A.J.S. (Albert J. S.), Kloet, A. (Alfred), Koopmans, J. (Jan), ter Laan, M. (Mark), Verstegen, M.J.T. (Marco), Wagemakers, M. (Michiel), and Robe, P.A. (Pierre A.)
- Abstract
Purpose: Standards for surgical decisions are unavailable, hence treatment decisions can be personalized, but also introduce variation in treatment and outcome. National registrations seek to monitor healthcare quality. The goal of the study is to measure between-hospital variation in risk-standardized survival outcome after glioblastoma surgery and to explore the association between survival and hospital characteristics in conjunction with patient-related risk factors. Methods: Data of 2,409 adults with first-time glioblastoma surgery at 14 hospitals were obtained from a comprehensive, prospective population-based Quality Registry Neuro Surgery in The Netherlands between 2011 and 2014. We compared the observed survival with patient-specific risk-standardized expected early (30-day) mortality and late (2-year) survival, based on age, performance, and treatment year. We analyzed funnel plots, logistic regression and proportional hazards models. Results: Overall 30-day mortality was 5.2% and overall 2-year survival was 13.5%. Median survival varied between 4.8 and 14.9 months among hospitals, and biopsy percentages ranged between 16 a
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- 2019
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11. Inter-rater agreement in glioma segmentations on longitudinal MRI
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Visser, M., primary, Müller, D.M.J., additional, van Duijn, R.J.M., additional, Smits, M., additional, Verburg, N., additional, Hendriks, E.J., additional, Nabuurs, R.J.A., additional, Bot, J.C.J., additional, Eijgelaar, R.S., additional, Witte, M., additional, van Herk, M.B., additional, Barkhof, F., additional, de Witt Hamer, P.C., additional, and de Munck, J.C., additional
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- 2019
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12. Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging
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Freyschlag, C.F., Krieg, S.M., Kerschbaumer, J., Pinggera, D., Forster, M.T., Cordier, D., Rossi, M., Miceli, G., Roux, A., Reyes, A., Sarubbo, S., Smits, A., Sierpowska, J., Robe, P.A., Rutten, G.J., Santarius, T., Matys, T., Zanello, M., Almairac, F., Mondot, L., Jakola, A.S., Zetterling, M., Rofes, A., Campe, G. von, Guillevin, R., Bagatto, D., Lubrano, V., Rapp, M., Goodden, J., Witt Hamer, P.C. de, Pallud, J., Bello, L., Thomé, C., Duffau, H., Mandonnet, E., Freyschlag, C.F., Krieg, S.M., Kerschbaumer, J., Pinggera, D., Forster, M.T., Cordier, D., Rossi, M., Miceli, G., Roux, A., Reyes, A., Sarubbo, S., Smits, A., Sierpowska, J., Robe, P.A., Rutten, G.J., Santarius, T., Matys, T., Zanello, M., Almairac, F., Mondot, L., Jakola, A.S., Zetterling, M., Rofes, A., Campe, G. von, Guillevin, R., Bagatto, D., Lubrano, V., Rapp, M., Goodden, J., Witt Hamer, P.C. de, Pallud, J., Bello, L., Thomé, C., Duffau, H., and Mandonnet, E.
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Contains fulltext : 195164.pdf (publisher's version ) (Open Access), Objective: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. Methods: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery. Results: A total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI. Conclusion: A minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of <= 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET. Importance of the study: We believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed "minimal core of imaging" in clinical routine will facilitate future cooperative studies.
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- 2018
13. Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis
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Verburg, N., primary, Hoefnagels, F.W.A., additional, Barkhof, F., additional, Boellaard, R., additional, Goldman, S., additional, Guo, J., additional, Heimans, J.J., additional, Hoekstra, O.S., additional, Jain, R., additional, Kinoshita, M., additional, Pouwels, P.J.W., additional, Price, S.J., additional, Reijneveld, J.C., additional, Stadlbauer, A., additional, Vandertop, W.P., additional, Wesseling, P., additional, Zwinderman, A.H., additional, and De Witt Hamer, P.C., additional
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- 2017
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14. Revisie richtlijn Gliomen: een overzicht van de belangrijkste wijzigingen
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van der Weide, H.L., Seute, T., Bossmann, S., Bromberg, J.E.C., de Vos, F.Y.F., Schrier, G.H., Smits, M., Versélewel de Witt Hamer, P.C., Neurosurgery, and CCA - Innovative therapy
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- 2015
15. Injury Response of Resected Human Brain Tissue In Vitro
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Verwer, R.W.H., Sluiter, A.A., Balesar, R.A., Baaijen, J.C., Versélewel de Witt Hamer, P.C., Speijer, D., Li, Y.C., Swaab, D.F., Neurosurgery, and Other Research
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- 2015
16. Accurate Delineation of Glioma Infiltration by Advanced PET/MR Neuro-Imaging (FRONTIER Study): A Diagnostic Study Protocol
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Verburg, N., Pouwels, P.J., Boellaard, R., Barkhof, F., Hoekstra, O.S., Reijneveld, J.C., Vandertop, W.P., Wesseling, P., Hamer, P.C., Verburg, N., Pouwels, P.J., Boellaard, R., Barkhof, F., Hoekstra, O.S., Reijneveld, J.C., Vandertop, W.P., Wesseling, P., and Hamer, P.C.
- Abstract
Item does not contain fulltext, BACKGROUND: Glioma imaging, used for diagnostics, treatment planning, and follow-up, is currently based on standard magnetic resonance imaging (MRI) modalities (T1 contrast-enhancement for gadolinium-enhancing gliomas and T2 fluid-attenuated inversion recovery hyperintensity for nonenhancing gliomas). The diagnostic accuracy of these techniques for the delineation of gliomas is suboptimal. OBJECTIVE: To assess the diagnostic accuracy of advanced neuroimaging compared with standard MRI modalities for the detection of diffuse glioma infiltration within the brain. METHODS: A monocenter, prospective, diagnostic observational study in adult patients with a newly diagnosed, diffuse infiltrative glioma undergoing resective glioma surgery. Forty patients will be recruited in 3 years. Advanced neuroimaging will be added to the standard preoperative MRI. Serial neuronavigated biopsies in and around the glioma boundaries, obtained immediately preceding resective surgery, will provide histopathologic and molecular characteristics of the regions of interest, enabling comparison with quantitative measurements in the imaging modalities at the same biopsy sites. DISCUSSION: In this clinical study, we determine the diagnostic accuracy of advanced imaging in addition to standard MRI to delineate glioma. The results of our study can be valuable for the development of an improved standard imaging protocol for glioma treatment. EXPECTED OUTCOME: We hypothesize that a combination of positron emission tomography, MR spectroscopy, and standard MRI will have a superior accuracy for glioma delineation compared with standard MRI alone. In addition, we anticipate that advanced imaging will correlate with the histopathologic and molecular characteristics of glioma. ABBREVIATIONS: CHO, [11C-]CholineCRF, case report formsFET, [18F-]Fluoroethyl-tyrosineFLAIR, fluid-attenuated inversion recoveryMETC, Medical Ethical CommitteeMRS, magnetic resonance spectroscopyPET, positron emission tomographyVUmc
- Published
- 2016
17. Third harmonic generation imaging for fast, label-free pathology of human brain tumors
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Kuzmin, N.V., Wesseling, P., Hamer, P.C., Noske, D.P., Galgano, G.D., Mansvelder, H.D., Baayen, J.C., Groot, M.L., Kuzmin, N.V., Wesseling, P., Hamer, P.C., Noske, D.P., Galgano, G.D., Mansvelder, H.D., Baayen, J.C., and Groot, M.L.
- Abstract
Contains fulltext : 171797.pdf (publisher's version ) (Open Access), In brain tumor surgery, recognition of tumor boundaries is key. However, intraoperative assessment of tumor boundaries by the neurosurgeon is difficult. Therefore, there is an urgent need for tools that provide the neurosurgeon with pathological information during the operation. We show that third harmonic generation (THG) microscopy provides label-free, real-time images of histopathological quality; increased cellularity, nuclear pleomorphism, and rarefaction of neuropil in fresh, unstained human brain tissue could be clearly recognized. We further demonstrate THG images taken with a GRIN objective, as a step toward in situ THG microendoscopy of tumor boundaries. THG imaging is thus a promising tool for optical biopsies.
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- 2016
18. Silent Diffuse Low-Grade Glioma: Toward Screening and Preventive Treatment?
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Mandonnet, E., Versélewel de Witt Hamer, P.C., Pallud, J., Bauchet, L., Whittle, I., Duffau, H., Neurosurgery, and CCA - Innovative therapy
- Published
- 2014
19. Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma
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Atai, N.A., Bansal, M., Lo, C., Bosman, J., Tigchelaar, W., Bosch, K.S., Jonker, A., de Witt Hamer, P.C., Troost, D., McCulloch, C.A., Everts, V., van Noorden, C.J.F., Sodek, J., Orale Celbiologie (ORM, ACTA), Faculteit der Geneeskunde, Neurosurgery, CCA - Immuno-pathogenesis, MOVE Research Institute, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Cell Biology and Histology, Amsterdam Neuroscience, Pathology, and Oral Cell Biology
- Subjects
stomatognathic system ,SDG 3 - Good Health and Well-being - Abstract
P>Osteopontin (OPN) is a glycophosphoprotein with multiple intracellular and extracellular functions. In vitro, OPN enhances migration of mouse neutrophils and macrophages. In cancer, extracellular OPN facilitates migration of cancer cells via its RGD sequence. The present study was designed to investigate whether osteopontin is responsible for neutrophil and macrophage infiltration in human cancer and in particular in glioblastoma. We found that in vitro mouse neutrophil migration was RGD-dependent. In silico, we found that the OPN gene was one of the 5% most highly expressed genes in 20 out of 35 cancer microarray data sets in comparison with normal tissue in at least 30% of cancer patients. In some types of cancer, such as ovarian cancer, lung cancer and melanoma, the OPN gene was one of those with the highest expression levels in at least 90% of cancer patients. In glioblastoma, the most invasive type of brain tumours/glioma, but not in lower grades of glioma it was one of the 5% highest expressed genes in 90% of patients. In situ, we found increased protein levels of OPN in human glioblastoma versus normal human brain confirming in silico results. OPN protein expression was co-localized with neutrophils and macrophages. In conclusion, OPN in tumours not only induces migration of cancer cells but also of leucocytes
- Published
- 2011
20. Neurocognitive outcome and resective brain tumor surgery in adults
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Klein, M.A., de Witt Hamer, P.C., Duffau, H., and Information, Marketing and Logistics
- Published
- 2011
21. Cortex-sparing fiber dissection: an improved method for the study of white matter anatomy in the human brain
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Martino, J., de Witt Hamer, P.C., Vergani, F., Brogna, C., de Lucas, E.M., Vazquez-Barquero, A., Garcia-Porrero, J.A., Duffau, H., Neurosurgery, and CCA - Innovative therapy
- Published
- 2011
22. Beloop en beleid bij vermoeden van een laaggradig glioom
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Sizoo, E.M., Reijneveld, J.C., Lagerwaard, F.J., Buter, J., Taphoorn, M.J.B., Versélewel de Witt Hamer, P.C., Neurology, Radiation Oncology, Medical oncology, Neurosurgery, and CCA - Innovative therapy
- Published
- 2010
23. P16.14 * BRAIN LOCATIONS INVOLVED IN COGNITIVE ALTERATIONS AFTER RESECTIVE BRAIN SURGERY IDENTIFIED BY RESECTION PROBABILITY MAPS
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Hendriks, E.J., Habets, E.J., Klein, M., Barkhof, F., Vandertop, W.P., Taphoorn, M.J., and Hamer, P.C. de Witt
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Poster Presentations ,Cancer Research ,Oncology ,Neurology (clinical) - Abstract
INTRODUCTION: Cognition is at risk in patients with brain tumors. Cognitive alterations, improvement or decline, may result from brain tumor surgery, as well as from other factors such as direct tumor effects, radiotherapy, chemotherapy, anti-epileptic drugs, and steroids. In this study, cognitive alterations after brain tumor surgery are quantified and correlated with brain location using resection probability maps, which is a new approach. METHODS: Adult patients were included, who had (1) a brain tumor, (2) resective surgery between 2006 and 2011, (3) baseline and postoperative (9-12 months) neuropsychological assessment in seven cognitive domains, and (4) pre- and postoperative MRI available. Resective surgery was performed with intraoperative stimulation mapping until functional boundaries were met. Resection probability maps quantify the likelihood of resection throughout the brain in 3D at 1 mm resolution in standard brain space. We compared resection probability maps of patients with and without cognitive alterations. Considerations for spatial dependence and multiple comparisons were taken into account. PRELIMINARY RESULTS: Seventy-four patients were so far included. The cognitive domains with most frequent and most extensive alterations after surgery were attentional function and working memory capacity. Results on the correlation between these cognitive changes and brain location are pending, but will be available in October 2014. CONCLUSION: Brain locations involved in cognitive improvement as well as decline in relation to resective surgery can be identified using resection probability maps. Brain tumors which are located in regions to be identified are associated with alterations in attention and verbal working memory.
- Published
- 2014
24. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.
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Mir, S.E., Witt Hamer, P.C. de, Krawczyk, P.M., Balaj, L., Claes, A., Niers, J.M., Tilborg, A.A. Van, Zwinderman, A.H., Geerts, D., Kaspers, G.J.L., Vandertop, W.P., Cloos, J., Tannous, B.A., Wesseling, P., Aten, J.A., Noske, D.P., Noorden, C.J.F. van, Wurdinger, T., Mir, S.E., Witt Hamer, P.C. de, Krawczyk, P.M., Balaj, L., Claes, A., Niers, J.M., Tilborg, A.A. Van, Zwinderman, A.H., Geerts, D., Kaspers, G.J.L., Vandertop, W.P., Cloos, J., Tannous, B.A., Wesseling, P., Aten, J.A., Noske, D.P., Noorden, C.J.F. van, and Wurdinger, T.
- Abstract
Contains fulltext : 88108.pdf (publisher's version ) (Closed access), Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene expression profiles of various tumor types and reveal the wee1 kinase to be overexpressed in glioblastomas. We demonstrate that WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells. Inhibition of WEE1 by siRNA or small molecular compound in cells exposed to DNA damaging agents results in abrogation of the G(2) arrest, premature termination of DNA repair, and cell death. Importantly, we show that the small-molecule inhibitor of WEE1 sensitizes glioblastoma to ionizing radiation in vivo. Our results suggest that inhibition of WEE1 kinase holds potential as a therapeutic approach in treatment of glioblastoma.
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- 2010
25. Connectivity in MEG resting-state networks increases after resective surgery for low-grade glioma and correlates with improved cognitive performance
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van Dellen, E., primary, de Witt Hamer, P.C., additional, Douw, L., additional, Klein, M., additional, Heimans, J.J., additional, Stam, C.J., additional, Reijneveld, J.C., additional, and Hillebrand, A., additional
- Published
- 2013
- Full Text
- View/download PDF
26. An abused five-month-old girl: Hangman's fracture or congenital arch defect?
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Rijn, R.R. van, Kool, D.R., Witt-Hamer, P.C. de, Majoie, C.B., Rijn, R.R. van, Kool, D.R., Witt-Hamer, P.C. de, and Majoie, C.B.
- Abstract
Item does not contain fulltext, Hangman's fractures are a rare finding in childhood. In case of suspected or proven child abuse, differentiation with a congenital defect of the posterior arch of C2 is essential. We present the case of a 5-month-old girl, who had a history of being physically abused by one of her caretakers. On the lateral view of the cervical spine, a defect of the posterior elements of C2 and an anterolisthesis of C2 on C3 was seen. CT scan showed a bilateral defect in the posterior elements of C2. No soft-tissue swelling of hematoma was noted. MRI showed a normal signal intensity of the intervertebral disc C2-C3. No haematoma was noted. Clinical examination revealed a slight head lag and local tenderness; there were no neurological deficits. This case shows that the differentiation between a congenital C2 arch defect and a hangman's fracture is precarious. In this case the findings on MRI and CT scan were interpreted as a congenital posterior arch defect (spondylolysis).
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- 2005
27. PO-0649 SURVIVAL IN PATIENTS WITH GLIOBLASTOMA RECEIVING OPTIMAL LOCAL TREATMENT
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Eppinga, W., primary, Lagerwaard, F.J., additional, de Haan, P.F., additional, de Witt Hamer, P.C., additional, Buter, J., additional, and Slotman, B.J., additional
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- 2012
- Full Text
- View/download PDF
28. Increase in cerebral metabolites during induction of propofol anaesthesia
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Bossers, S.M., primary, Peerdeman, S.M., additional, Oedayrajsingh Varma, P., additional, Baayen, J.C., additional, De Witt Hamer, P.C., additional, Schauer, A., additional, Loer, S.A., additional, and Boer, C., additional
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- 2012
- Full Text
- View/download PDF
29. An abused five-month-old girl: Hangman’s fracture or congenital arch defect?
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van Rijn, R.R., primary, Kool, D.R., additional, de Witt Hamer, P.C., additional, and Majoie, C.B., additional
- Published
- 2005
- Full Text
- View/download PDF
30. Connectivity in MEG resting-state networks increases after resective surgery for low-grade glioma and correlates with improved cognitive performance☆
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van Dellen, E., de Witt Hamer, P.C., Douw, L., Klein, M., Heimans, J.J., Stam, C.J., Reijneveld, J.C., and Hillebrand, A.
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Glioma ,Resective surgery ,Cognition ,Magnetoencephalography ,Resting-state networks ,Functional connectivity - Abstract
Purpose Low-grade glioma (LGG) patients often have cognitive deficits. Several disease- and treatment related factors affect cognitive processing. Cognitive outcome of resective surgery is unpredictable, both for improvement and deterioration, especially for complex domains such as attention and executive functioning. MEG analysis of resting-state networks (RSNs) is a good candidate for presurgical prediction of cognitive outcome. In this study, we explore the relation between alterations in connectivity of RSNs and changes in cognitive processing after resective surgery, as a stepping stone to ultimately predict postsurgical cognitive outcome. Methods: Ten patients with LGG were included, who had no adjuvant therapy. MEG recording and neuropsychological assessment were obtained before and after resective surgery. MEG data were recorded during a no-task eyes-closed condition, and projected to the anatomical space of the AAL atlas. Alterations in functional connectivity, as characterized by the phase lag index (PLI), within the default mode network (DMN), executive control network (ECN), and left- and right-sided frontoparietal networks (FPN) were compared to cognitive changes. Results: Lower alpha band DMN connectivity was increased after surgery, and this increase was related to improved verbal memory functioning. Similarly, right FPN connectivity was increased after resection in the upper alpha band, which correlated with improved attention, working memory and executive functioning. Discussion Increased alpha band RSN functional connectivity in MEG recordings correlates with improved cognitive outcome after resective surgery. The mechanisms resulting in functional connectivity alterations after resection remain to be elucidated. Importantly, our findings indicate that connectivity of MEG RSNs may be used for presurgical prediction of cognitive outcome in future studies.
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- 2012
- Full Text
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31. P16.12 BRAIN LOCATIONS INVOLVED IN BASELINE COGNITIVE FUNCTIONING OF PATIENTS WITH GLIOMA BEFORE THERAPY.
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Habets, E.J.J., Hendriks, E.J., Taphoorn, M.J.B., Barkhof, F., Vandertop, W.P., Hamer, P.C. De Witt, and Klein, M.
- Published
- 2014
- Full Text
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32. Collaborations in cancer care: contemporary approach toward comprehensive cancer networks
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de Swart, Merijn Elise, Kazemier, Geert, de Witt Hamer, P.C., Schuur, M., Kouwenhoven, M.C.M., VUmc - School of Medical Sciences, de Witt Hamer, Philip, Schuur, Maaike, Kouwenhoven, Mathilde, and VU University medical center
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SDG 16 - Peace ,SDG 3 - Good Health and Well-being ,SDG 16 - Peace, Justice and Strong Institutions ,Justice and Strong Institutions - Abstract
This thesis entitled ‘Collaborations in cancer care – contemporary approach toward comprehensive cancer networks’ aims to explore and optimize collaborations in transmural cancer care, first by examining the role of time intervals to treatment and second by establishing and advancing referrals, mainly focused on two cancer (sub)types; colorectal liver metastases and glioblastoma. The timing of glioblastoma treatment varies considerably in clinical practice. Regarding to neurosurgery, with current decision-making, initial presentation at the outpatient clinic, higher preoperative performance status, and smaller tumor volume are risk factors for delayed neurosurgery. The timing of glioblastoma surgery may be associated with postoperative performance improvements and survival. Timely glioblastoma surgery appears to have a favorable impact on survival in patients with tumor volumes greater than 50 mL or seizure as the only preoperative symptom. Regarding to (chemo)radiotherapy, larger extent of resection, university affiliation, and more recent year of treatment are risk factors for delayed start of this treatment. Regarding to adjuvant chemotherapy, higher postoperative performance status is a risk factor for delayed initiation of adjuvant chemotherapy. Therefore, patients should undergo neurosurgery as soon as feasible, with a maximum acceptable time interval of 4 weeks after careful patient’s triage, and radiotherapy should neither be forced nor delayed, but rather start timely as soon as the patient has recovered from surgery. Complex cancer care is increasingly concentrated in specialized and academic hospitals. The extent of concentration of care varies between cancer pathways, with rare tumors more likely to be already concentrated. With concentration of care, patients are referred between hospitals. The current lack of digital access to medical records across hospitals leads to loss of patient information in the majority of oncological referrals. In addition, the distribution of care among multiple hospitals impedes between-hospital consultation, resulting in undertreatment, delayed referrals and initiation of treatment, and needless referrals. Improvement of patient information exchange and referral management by telehealth innovations could contribute to optimize oncological referrals. Digital consultation of multidisciplinary expert or triage panels are feasible approaches to provide non-specialized hospitals with tumor-specific expertise for appropriate referral management. Collaboration between healthcare providers among hospitals in regional cancer networks could contribute to the continuity of transmural oncological care.
- Published
- 2023
33. Advanced Imaging in Glioma Treatment: Moving the Frontier
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Verburg, N., Vandertop, William, Wesseling, Pieter, Versélewel de Witt Hamer, Philip, CCA - Imaging and biomarkers, Neurosurgery, Vandertop, W.P., Wesseling, P., and de Witt Hamer, P.C.
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PET ,glioma ,imaging ,diagnostic accuracy ,multimodality - Published
- 2020
34. Research into neuropsychological assessment and cognitive rehabilitation in brain tumor patients after surgery
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van der Linden, S.D., Sitskoorn, Margriet, Rutten, Geert-Jan, Gehring, Karin, Fasotti, L., Nijboer, Tanja Cornelia Wilhelmina, Sanderman, R., Snijders, T.J., de Witt Hamer, P.C., and Cognitive Neuropsychology
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- 2020
35. Accurate quantification of glioma on MRI
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Visser, M, Barkhof, F., de Munck, Jan, de Witt Hamer, P.C., Barkhof, Frederik, Versélewel de Witt Hamer, Philip, Radiology and nuclear medicine, and Amsterdam Neuroscience - Brain Imaging
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automatic segmentation ,glioma ,linear image registration ,non-linear image registration ,manual segmentation ,inter-rater agreement ,MRI - Published
- 2020
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