Search

Malignant tumors are complicated structures of cancer cells that are constantly in communication with their local and distant environment. Exosomes are released by tumor cells and can facilitate the cell-cell interaction within the local microenvironment and the primary tumor. In fact, exosomes are secreted by both tumor and non-tumor cells, to provide a mutual communication network between cells and their micro- and/or macro-environments. Exososmes can contain a variety of biological cargos mostly based on their originated cells. Uptake of these exosomes by their recipient cells results in the alterations that their cargo can exert. MicroRNAs are identified as one of the most critical exosomal components, considering their pivotal regulatory roles in distinct biological process, including metastasis. Release and absorbance of exosomal microRNAs is possible by various cells within the host, and can have distinct biological consequences. Therefore, in this review we will discuss the role of exosomal microRNAs derived from tumor cells and untransformed cells within their micro- and macroenvironment in cancer progression and metastasis., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Fahad Alsaikhan reports financial support was provided by Prince Sattam bin Abdulaziz University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier GmbH. All rights reserved.)

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. These biopolymers possess unique physicochemical (such as surface functional groups, solubility, and stability), mechanical (like mechanical strength and tensile), and biomedical (such as antioxidant activity, biocompatibility, biodegradability, renewability, and non-immunogenicity) characteristics which have made them excellent platforms for a wide variety of biomedical and pharmaceutical applications. Ease of extraction and different preparation approaches are mentioned as other potential properties of polysaccharides that further improved their practicality in biomedical sciences. They have high drug/bioactive encapsulation capacity and sustained/controlled release manner in in vivo microenvironments. The anti-inflammatory and immunomodulation, stimuli-responsive drug/bioactive release, and passive and active drug/bioactive delivery are considered the potential features of these biopolymers in pharmaceutical sciences. Polysaccharides have indicated practical applications in biomedical sciences, including biosensors, tissue engineering, implantation, wound healing, vascular grafting, and vaccines. This review highlights the advances of polysaccharide-based materials in biomedical and pharmaceutical sciences., (© 2024 Deutsche Pharmazeutische Gesellschaft.)

The rapid growth in the world-population urges the need for potable water in various regions, especially in hot and dry regions. The main challenge in the productivity of potable water is the cost and availability of water sources. Thus, it is crucial to develop effective methods to overcome this global need. Utilizing solar power is proven to be a promising path to implementing thermal solar radiation in solar distillation applications. This work investigates the effectiveness of using concentrated solar power to irradiate heat exchange to evaporate water in a receiver, which will be collected as pure water in a condenser later. The thermal performance of the proposed model and its productivity are tested experimentally by using tap water only, and the test was repeated twice using two nanofluids namely, (aluminium oxide (Al2O3) and zinc oxide (ZnO)). The results showed that using (Al2O3) has a superior influence on the productivity of the solar unit, where the productivity is increased by 43.53% and 21.89% when compared to tap water and zinc oxide (ZnO) nanofluid respectively. The thermal efficiency of the solar unit was also increased by 9.91% (maximum) when using (aluminium oxide (Al2O3) as a working fluid compared to tap water. The model has simple components and is easy to install with a compact size, which can be developed be utilized in urban and desert areas., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

Objectives: To determine the prevalence of exclusive and continued breastfeeding in an urban setting, and the factors influencing the choice., Methods: The cross-sectional study was conducted from February 1 to August 30, 2018, in Najaf, Iraq, and comprised children aged up to 2 years from 12 randomly selected primary healthcare centres. Data were collected using a predesigned questionnaire that had three parts covering the mother, the child and the demographic variables. Data was analysed using SPSS 20., Results: Of the 373 subjects, 209(56.0%) were males. The overall mean age was 8.8± 6.2 months (range: 1-23 months), while the mean age of the mothers was 26.5±5.8 years (range: 15-46 years). Children aged <6 months were 169(45.3%), and, among them, exclusive breastfeeding was found in 66(39.1%) cases. There was significant relationship between exclusive breastfeeding and feeding of other siblings (p=0.001), admission to hospital (p=0.02), family support (p=0.009), husband's support (p=0.007). Child sickness in early life also had significant association with exclusive breastfeeding (p<0.05)., Conclusions: The prevalence of exclusive breastfeeding was found within the reported estimate for low- and middle-income countries, but much lower than the World Health Organisation recommendation.

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of several cancer cell lines. The aim of this study is to compare the cytotoxic effect of aspirin with diclofenac on the growth of HeLa cell, mammary cell carcinoma, rhabdomyosarcoma and fibroblast cell lines in the culture media. The cells are cultured in RPMI-1640 culture media supplemented with 5% fetal calf serum and antibiotics. Aspirin (5 mg/well) and diclofenac (0.625 mg/well) significantly inhibit the growth of HeLa, rhabdomyosarcoma and fibroblast cells. The cytotoxic effect of aspirin against rhabdomyosarcoma is significantly (p < 0.001) higher than that of diclofenac with a potency approximated 2.6. It concludes that aspirin and diclofenac inhibit the growth of fibroblast and cancer cell by inhibiting the up-regulation of cyclooxygenases enzymes in cancer cells. Aspirin is more effective than diclofenac against the growth of rhabdomyosarcoma cell line.