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5 results on '"Hamed Mohamed Abdel-Bary"'

1. Phytochemical Characterization and Evaluation of Biological Activities of Egyptian Carob Pods (Ceratonia siliqua L.) Aqueous Extract: In Vitro Study

Author

Wael Sobhy Darwish, Abada El Sayed Khadr, Maher Abd El Naby Kamel, Mabrouk A. Abd Eldaim, Ibrahim El Tantawy El Sayed, Hamed Mohamed Abdel-Bary, Sami Ullah, and Doaa Ahmed Ghareeb

Subjects
Ceratonia siliqua, carob, flavonoids, polyphenols, antihemolytic, antimicrobial, Botany, QK1-989
Abstract

Ceratonia siliqua (Carob) is an evergreen Mediterranean tree, and carob pods are potentially nutritive and have medicinal value. The present study was carried out to estimate the possible biological activities of phytochemical-characterized carob pod aqueous extract (CPAE). The phytochemical contents of CPAE were determined by using colorimetric methods and HPLC. In addition, the free radical scavenging properties and anti-diabetic, anti-hemolytic, and antimicrobial activities were estimated by using standardized in vitro protocols. The phytochemical analysis revealed that CPAE was rich in polyphenols, flavonoids, and alkaloids, where it contained a significant amount of gallic acid, catechin, and protocatechuic acid. Furthermore, CPAE exhibited strong antioxidant activity where it prevented the formation of 2, 2-Diphenyl-1-picryl hydrazyl, hydroxyl, and nitric oxide free radicals. Additionally, it had a potent inhibitory effect against digestive enzymes (amylase, maltase, sucrase, and lactase). Moreover, CPAE exhibited anti-Staph aureus, anti-Escherichia coli, anti-Candida albicans, and anti-herpes simplex type I virus (HSV-I). Finally, CPAE protected the erythrocyte membrane from hypotonic solution-induced hemolysis. Altogether, CPAE could be regarded as an interesting source of biologically active antioxidant, anti-diabetic, and antimicrobial preparation for a potential application in pharmaceutical and food supplement fields.

Published
2021
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2. Direct Relationship between Interleukin-10 Gene Polymorphism and Hepatocellular Carcinoma Complicated by Direct Acting Antiviral Treatment of Hepatitis C Virus

Author

Samar Ebrahim Ghanm, Warda Othman Saad, Basant Farid Saad, Ibrahim El Tantawy El Sayed, Nashwa Shebl, and Hamed Mohamed Abdel-Bary

Subjects
Simeprevir, Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Daclatasvir, Cirrhosis, Carcinoma, Hepatocellular, Pyrrolidines, Sofosbuvir, Hepatitis C virus, Hepacivirus, medicine.disease_cause, Gastroenterology, Antiviral Agents, Polymorphism, Single Nucleotide, chemistry.chemical_compound, Lymphadenitis, Internal medicine, Ribavirin, medicine, Humans, Aged, business.industry, Liver Neoplasms, Imidazoles, Ascites, Valine, General Medicine, Hepatitis C, Chronic, Middle Aged, medicine.disease, digestive system diseases, Interleukin-10, Regimen, chemistry, Hepatocellular carcinoma, Splenomegaly, Drug Therapy, Combination, Female, Carbamates, business, medicine.drug
Abstract

Objective This study aimed to assess the correlation between the genotyping of interleukin-10 (IL-10 polymorphism rs 1800871) and the incidence hepatocellular carcinoma (HCC) among patients with hepatitis C virus (HCV) treated with direct acting antivirals (DAAs). Method For 200 patients with HCV infection who completed DAA treatment and followed up for 1 year, IL-10 polymorphism SNP(-819) rs 1800871 analysis was conducted via real time polymerase chain reaction. During the follow-up period, 100 patients who developed HCC were selected and compared with 100 patients who did not develop any complications. Results The studied patients were divided into two groups according to the incidence of complications after completion of DAA treatments. During the follow-up, 100 patients with HCV infection who developed HCC were selected and compared with 100 patients with HCV infection who did not develop any complications (positive control group). For the HCC group (n = 100), the mean age was 58.1 ± 6.4 years, with 92.7% being male and 7.3% being female; 91% had cirrhosis, 10% had lymphadenitis, 75% had splenomegaly, and 17% had ascites. In the positive control group (n = 100), mean age was 46.3 ± 9.4 years, with 68% being male and 32% being female; 20% had cirrhosis, 12% had splenomegaly, and 4.2% had ascites. The results demonstrated that sofosbuvir (SOF) + daclatasvir + ribavirin regimen was the most prevalent drug treatment for patients with HCC (72%), while SOF + Simeprevir was the most safe treatment for HCV infection among patients with HCC (2%). CT genotype was the most common genotype in the HCC group (56%), among different drug regimen (67.8%). T allele was the most prevalent in HCC group (61%), while the C allele was the least prevalent (39%). Conclusion IL-10 genotyping may help in selecting the safest and most accurate drug regimen according to the safest genotype response relationship and follow-up of genotype resistance.

Published
2021

3. Amino acid derivatives, X [1]: synthesis and antimicrobial evaluation of α-amino acid esters bearing a N1-protected tryptophan side chain

Author

Hamed Mohamed Abdel-Bary, Emad M. I. Morcy, Mohamed T. Shabaan, Adel A.-H. Abdel-Rahman, Ahmed E.-S. Abdel-Megied, and Abdel-Aleem H. Abdel-Aleem

Subjects
chemistry.chemical_classification, Residue (chemistry), chemistry, Stereochemistry, Side chain, Tryptophan, Peptide, General Chemistry, Conjugated system, Antimicrobial, Amino acid
Abstract

A series of peptide derivatives conjugated with N1-protected tryptophan residue was synthesized. The prepared compounds were tested for antimicrobial activity against four different bacterial species displaying different degrees of antibacterial activities or inhibitory actions.

Published
2008

4. ChemInform Abstract: Reactions with Thiaxanthen-9-ol: New Thiaxanthene Derivatives with Molluscicidal and Nematocidal Activity

Author

A. E. S. Abdel‐Mageed, Hamed Mohamed Abdel-Bary, Ibrahim A. El-Sakka, and Ibrahim F. Zeid

Subjects
Chemistry, General Medicine, Medicinal chemistry
Abstract

Thiaxanthen-9-ol (1) was condensed with nitriles 2a-e to yield the thiaxanthen-9-yl-acetonitriles 3a-e. With the thiols 7a-d, 1 yielded the thioethers 8a-d. Reaktionen von Thioxanthen-9-ol: Synthese neuer Thioxanthen-Derivate, die moglicherweise molluskizid und nematozid wirken Thiaxanthen-9-ol (1) wurde mit den aktiven Methylennitrilen 2a-e zu den Thiaxanthennitrilen 3a-e und mit den Thiolen 7a-d zu den Thioethern 8a-d kondensiert. Die Reaktionen dieser Thioether bei der Oxidation mit Wasserstoffperoxid wurde untersucht.

Published
2010

5. Reactions with thiaxanthen-9-ol: new thiaxanthene derivatives with molluscicidal and nematocidal activity

Author

A. E. S. Abdel‐Mageed, Ibrahim A. El-Sakka, Ibrahim F. Zeid, and Hamed Mohamed Abdel-Bary

Subjects
chemistry.chemical_classification, Acetonitriles, Molluscacides, Chemistry, Antinematodal Agents, Snails, Pharmaceutical Science, Biological activity, chemistry.chemical_compound, Drug Discovery, Thioxanthenes, Thiol, Organic chemistry, Animals, Tylenchoidea, Malononitrile
Abstract

Thiaxanthen-9-ol (1) was condensed with nitriles 2a-e to yield the thiaxanthen-9-yl-acetonitriles 3a-e. With the thiols 7a-d, 1 yielded the thioethers 8a-d. Reaktionen von Thioxanthen-9-ol: Synthese neuer Thioxanthen-Derivate, die moglicherweise molluskizid und nematozid wirken Thiaxanthen-9-ol (1) wurde mit den aktiven Methylennitrilen 2a-e zu den Thiaxanthennitrilen 3a-e und mit den Thiolen 7a-d zu den Thioethern 8a-d kondensiert. Die Reaktionen dieser Thioether bei der Oxidation mit Wasserstoffperoxid wurde untersucht.

Published
1994

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