1. Modified cotton gauze with nano-Ag decorated alginate microcapsules and chitosan loaded with PVP-I
- Author
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Ramin Khajavi, Mohammad KarimRahimi, Hamed Hajimirzababa, and Mohammad Mirjalili
- Subjects
Materials science ,Polymers and Plastics ,Materials Science (miscellaneous) ,Substrate (chemistry) ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,Silver nanoparticle ,0104 chemical sciences ,Chitosan ,chemistry.chemical_compound ,chemistry ,Wound dressing ,Polymer chemistry ,Water holding capacity ,Control sample ,0210 nano-technology ,General Agricultural and Biological Sciences ,Nuclear chemistry ,Cotton gauze - Abstract
This study was aimed at improving the conventional cotton gauze for achieving advanced wound dressing specifications. Firstly, microcapsules of alginate (Alg-MC) were formed and silver nanoparticles (AgNPs) were synthesized in situ inside (Method I: Ag/Alg-MC) or on (Method II: Ag@Alg-MC) Alg-MC. A solution of chitosan (CS) containing already prepared povidone-iodine (PVP-I) was loaded with Ag/Alg-MC or with Ag@Alg-MC. Finally, conventional cotton gauze substrate was impregnated with these two prepared dispersions and dried. Both samples showed antibacterial properties against gram-negative (Escherichia coli) and gram-positive bacterium (Staphylococcus aureus). Their water absorbency, water holding capacity, and vertical wicking increased by 55, 28, and 33%, respectively, in comparison with the control sample. Ag@Alg-MC showed burst release in comparison with Ag/Alg-MC. The conventional properties of cotton gauze were greatly improved by the introduced method and it was regarded as a proper candid...
- Published
- 2017
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