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2. Big Data Analytics in innovation context

Author

Hamadi, Abdullah, Hajli, Nick, Ibrahim, Fahad, and Mulyata, John

Abstract

The potential of big data analytics (BDA) in enabling improvements in business processes has urged researchers and practitioners to understand whether and under what combination of conditions, such novel technologies can support innovation, competitive advantage, and firm performance. Although the extent of research in this area is substantial, research on the influence of the BDA components such as effective use of big data analytics tools and big data management on innovation process (IP), competitive advantage (CA), and financial performance (FP) must be conducted. This research examines the impact of effective use of BDA tools and big data management on the innovation process, competitive advantage and financial performance based on the resource-based view (RBV). Based on this conceptualisation, the current study examines the relationship between the BDA components (effective use of BDA tools and big data management) on the innovation process, competitive advantage, and financial performance. A questionnaire was designed to measure the influence of the effective use of big data analytics tools and big data management on the innovation process and its drivers on competitive advantage and financial performance. Quantitative data collected using an online survey method, and (n= 174) samples were gathered from top managers working in firms operating in the United Kingdom and the United States of America. The hypotheses and model fitness were tested in SPSS, AMOS v.26 using structural equation modelling (SEM). The findings indicate that applying the significant data analytics components (effective use of BDA tools and big data management) has a significant positive impact on the innovation process capabilities (β = .317, p = 0.000 and β = .490, p = 0.000), competitive advantage (β = .322, p = 0.000 and β = .298, p = 0.000), and financial performance (β = .188, p = 0.000 and β = .444 and p = 0.000). There is also a significant positive impact of the innovation process on competitive advantage (β = .485, p = 0.000), and the competitive advantage led to a financial performance (β = .397, p = 0.000). Statistical findings also show that the innovation process as mediator has a significant positive impact on financial performance (β = .333, p = 0.000). Surprisingly, firm mediators such as age (β = -.002 and p = 0.000), size (β = -.003 with p = 0.000), type of industry (β = -.008 with p = 0.000), and environment turbulence (β = -.001 with p = 0.000), were found not to positively impact a firm's financial performance. This work provides an original contribution to knowledge by extending and validating a new model and the factors affecting the innovation process, competitive advantage, and financial performance.

Published
2022
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8. Unrevealing the multitargeted potency of 3-1-BCMIYPPA against lung cancer structural maintenance and suppression proteins through pharmacokinetics, QM-DFT, and multiscale MD simulation studies.

Author

Alshehri, Mohammed Ali, Asiri, Saeed A., Helmi, Nawal, Baeissa, Hanadi M., Hamadi, Abdullah, Alzahrani, Abdulrahman, Alghamdi, Rashed Mohammed, Rafeeq, Misbahuddin M., Alharbi, Zeyad M., and Kamal, Mohammad Azhar

Subjects
LUNG cancer, INSULIN receptors, PHARMACOKINETICS, DRUG design, EPIDERMAL growth factor receptors, GROWTH factors
Abstract

Lung cancer, a relentless and challenging disease, demands unwavering attention in drug design research. Single-target drugs have yielded limited success, unable to effectively address this malignancy's profound heterogeneity and often developed resistance. Consequently, the clarion call for lung cancer drug design echoes louder than ever, and multitargeted drug design emerges as an imperative approach in this landscape, which is done by concurrently targeting multiple proteins and pathways and offering a beacon of hope. This study is focused on the multitargeted drug designing approach by identifying drug candidates against human cyclin-dependent kinase-2, SRC-2 domains of C-ABL, epidermal growth factor and receptor extracellular domains, and insulin-like growth factor-1 receptor kinase. We performed the multitargeted molecular docking studies of Drug Bank compounds using HTVS, SP and XP algorithms and poses filter with MM\GBSA against all proteins and identified DB02504, namely [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid (3-1-BCMIYPPA) as multitargeted lead with docking and MM\GBSA score range from -8.242 to -6.274 and -28.2 and -44.29 Kcal/mol, respectively. Further, the QikProp-based pharmacokinetic computations and QM-based DFT showed acceptance results against standard values, and interaction fingerprinting reveals that THR, MET, GLY, VAL, LEU, GLU and ASP were among the most interacting residues. The NPT ensemble-based 100ns MD simulation in a neutralised state with an SPC water model has also shown a stable performance and produced deviation and fluctuations <2Å with huge interactions, making it a promising multitargeted drug candidate—however, experimental studies are suggested. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population

Author

Jalal, Mohammed M., primary, Mir, Rashid, additional, Hamadi, Abdullah, additional, Altayar, Malik A., additional, Elfaki, Imadeldin, additional, Barnawi, Jameel, additional, Alkayyal, Almohanad A., additional, Amr, Mouminah, additional, Hadeel, Jabali, additional, Moawadh, Mamdoh S., additional, Alsaedi, Basim S. O., additional, Alhelali, Marwan H., additional, and Yousif, Aadil, additional

Published
2023
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12. Interleukin-10 as Covid-19 biomarker targeting KSK and its analogues: Integrated network pharmacology

Author

V., Vidhya Rajalakshmi, primary, Ramu, Akilandeswari, additional, Chinnappan, Jayaprakash, additional, Velmurugan, Palanivel, additional, Pathak, Rajiv, additional, Pashameah, Rami Adel, additional, A. Oyouni, Atif Abdulwahab, additional, M. Al-Amer, Osama, additional, I. Alasseiri, Mohammed, additional, Hamadi, Abdullah, additional, A. Alanazi, Mansuor, additional, and Sathiamoorthi, Thangavelu, additional

Published
2023
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13. A Novel Loss of Function Variant in HCN1Gene Underlies Early Infantile Epileptic Encephalopathy 24 [EIEE24]

Author

Waqas, Ahmed, Almazni, Ibrahim A., Zaman, Gohar, Alam, Qamre, Eid, Thamir M., Alanazi, Mohammad A., Hamadi, Abdullah, Afsar, Tayyaba, Razak, Suhail, and Umair, Muhammad

Abstract

Background:Early infantile epileptic encephalopathy (EIEE) is a rare neurological condition characterized by frequent seizures in the early stages of life, resulting in severely impaired cognitive and motor development. Although the specific causes of EIEE remain unknown, one of the primary causes is gene pathogenicity (even in the absence of consanguinity). Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) are essential for proper brain function. They are regulated by multiple genes, and mutations in these genes induce channel malfunction, which can result in various severe conditions, including EIEE. Herein, we have reported a patient presenting hallmarks of EIEE. Methods:The patient underwent clinical, radiographic, and genetic analysis. A thorough clinical examination and molecular study were conducted utilizing whole exome sequencing and Sanger sequencing. Results:Whole exome sequencing of the proband revealed a novel de novo nonsynonymous/nonsense variant (c.1468A>T; (p.Lys490Ter) in exon 6 of the HCN1gene. This variant may cause channel dysfunction via nonsynonymous/nonsense-mediated decay or aberrant protein, which may be associated with EIEE phenotypes. Conclusions:This evidence backs the idea that HCN1 has a vital role in brain development and lose of function can cause a range of debilitating conditions. Still, the functional characterization study of the HCN1variants will be the fundamental tool for a better understanding of EIEE in the near future.

Published
2024
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14. Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma

Author

Al-Amer, Osama M., primary, Mir, Rashid, additional, Hamadi, Abdullah, additional, Alasseiri, Mohammed I., additional, Altayar, Malik A., additional, AlZamzami, Waseem, additional, Moawadh, Mamdoh, additional, Alatawi, Sael, additional, Niaz, Hanan A., additional, Oyouni, Atif Abdulwahab A., additional, Alzahrani, Othman R., additional, Alatwi, Hanan E., additional, Albalawi, Aishah E., additional, Alsharif, Khalaf F., additional, Albrakati, Ashraf, additional, and Hawsawi, Yousef M., additional

Published
2023
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16. The correlation between severe complications and blood group types in COVID-19 patients; with possible role of T polyagglutination in promoting thrombotic tendencies

Author

Dobie, Gasim, primary, Abutalib, Sarah, additional, Sadifi, Wafa, additional, Jahfali, Mada, additional, Alghamdi, Bayan, additional, Khormi, Asmaa, additional, Alharbi, Taibah, additional, Zaqan, Munyah, additional, Baalous, Zahra M, additional, Hakami, Abdulrahim R, additional, Nahari, Mohammed H, additional, Mobarki, Abdullah A, additional, Saboor, Muhammad, additional, Akhter, Mohammad S, additional, Hamadi, Abdullah, additional, Jackson, Denise E, additional, and Hamali, Hassan A, additional

Published
2023
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18. Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19).

Author

Dobie, Gasim, Hamali, Hassan A., Mobarki, Abdullah A., Saboor, Muhammad, Akhter, Mohammad S., Hakami, Khaled Essawi Abdulrahim R., Nahari, Mohammed H., Kolaiby, Mohamed A., Matari, Yahya H., Atafi, Essa, Ghubiri, Ghalib, Alhamzi, Abdulrahman A., Alhamzi, Abdulrhman, Halawani, Amr J., Hamadi, Abdullah, and Jackson, Denise E.

Abstract

T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation polyagglutination in critically ill COVID-19 patients. Anti-T Arachis hypogaea lectin was incubated with the red blood cells of the COVID-19 patient and checked for agglutination. Thirty-four percent (34.3%) of COVID-19 patients in the intensive care unit (ICU) had potentially activated T cells and polyagglutinable red blood cells, as demonstrated by their cryptantigen exposure that caused agglutination. The study revealed a high prevalence of anti-T among ICU-admitted COVID-19 patients, suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause transient T activation, polyagglutination in critically ill COVID-19 patients in vitro and possibly haemolysis in vivo. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Developing a Multimodal Model for Detecting Higher-Grade Prostate Cancer Using Biomarkers and Risk Factors

Author

Velmurugan, Palanivel, primary, Mohanavel, Vinayagam, additional, Shrestha, Anupama, additional, Sivakumar, Subpiramaniyam, additional, Oyouni, Atif Abdulwahab A., additional, Al-Amer, Osama M., additional, Alzahrani, Othman R., additional, Alasseiri, Mohammed I., additional, Hamadi, Abdullah, additional, and Alalawy, Adel Ibrahim, additional

Published
2022
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20. Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease

Author

Hamadi, Abdullah, primary, Mir, Rashid, additional, Mahzari, Ali, additional, Hakami, Abdulrahim, additional, Almotairi, Reema, additional, Dobie, Gasim, additional, Hamdi, Fawaz, additional, Nahari, Mohammed, additional, Alhefzi, Razan, additional, Alasseiri, Mohammed, additional, Hakami, Nora, additional, Al Sadoun, Hadeel, additional, Al-Amer, Osama, additional, Barnawi, Jameel, additional, and Madkhali, Hassan, additional

Published
2022
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21. Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic Predisposition to PCOS

Author

Mir, Rashid, primary, Saeedi, Nizar H., additional, Jalal, Mohammed M., additional, Altayar, Malik A., additional, Barnawi, Jameel, additional, Hamadi, Abdullah, additional, Tayeb, Faris J., additional, Alshammari, Sanad E., additional, Mtiraoui, Nabil, additional, M. Ali, Mohammed Eltigani, additional, Abuduhier, Faisel M., additional, and Ullah, Mohammad Fahad, additional

Published
2022
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24. Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome

Author

Mir, Rashid, primary, Tayeb, Faris J., additional, Barnawi, Jameel, additional, Jalal, Mohammed M., additional, Saeedi, Nizar H., additional, Hamadi, Abdullah, additional, Altayar, Malik A., additional, Alshammari, Sanad E., additional, Mtiraoui, Nabil, additional, Ali, Mohammed Eltigani, additional, Duhier, Faisel M. Abu, additional, and Ullah, Mohammad Fahad, additional

Published
2022
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25. Impact of COVID-19 on Blood Donation and Supply: A Multicenter Cross-Sectional Study from Saudi Arabia

Author

Hakami, Nora Y., primary, Al-Sulami, Afnan J., additional, Alhazmi, Wafaa A., additional, Qadah, Talal H., additional, Bawazir, Waleed M., additional, Hamadi, Abdullah Y., additional, Owaidah, Amani Y., additional, Alhefzi, Razan A., additional, Hamdi, Fawaz Y., additional, Maqnas, Amr, additional, Alghassab, Ghassab F., additional, Badawi, Maha A., additional, and Hindawi, Salwa I., additional

Published
2022
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28. Molecular Determination of mirRNA-126 rs4636297, Phosphoinositide-3-Kinase Regulatory Subunit 1-Gene Variability rs7713645, rs706713 (Tyr73Tyr), rs3730089 (Met326Ile) and Their Association with Susceptibility to T2D

Author

Mir, Rashid, primary, Elfaki, Imadeldin, additional, Duhier, Faisel M. Abu, additional, Alotaibi, Maeidh A., additional, AlAlawy, Adel Ibrahim, additional, Barnawi, Jameel, additional, Babakr, Abdullatif Taha, additional, Mir, Mohammad Muzaffar, additional, Mirghani, Hyder, additional, Hamadi, Abdullah, additional, and Dabla, Pradeep Kumar, additional

Published
2021
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29. A Rare Pediatric Case Report With Review of Literature for the Diagnosis of Acute Megakaryoblastic Leukemia (FAB M7)

Author

Theyab, Abdulrahman, primary, Algahtani, Mohammad, primary, Dobie, *Gasim, primary, Hamali, Hassan A, primary, Mobarki, Abdullah A, primary, Saboor, Muhammed, primary, Halawani, Amr J, primary, Nahari, Mohammed H, primary, Hakami, Abdulrahim R, primary, Hamadi, Abdullah, primary, Alsharif, Khalaf H, primary, and Jackson, Denise E, primary

Published
2021
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31. Correction: Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.

Author

Al-Amer, Osama M., Oyouni, Atif Abdulwahab A., Alshehri, Mohammed Ali, Alasmari, Abdulrahman, Alzahrani, Othman R., Aljohani, Saad Ali S., Alasmael, Noura, Theyab, Abdulrahman, Algahtani, Mohammad, Al Sadoun, Hadeel, Alsharif, Khalaf F., Hamadi, Abdullah, Abdali, Wed A., and Hawasawi, Yousef MohammedRabaa

Subjects
IRON in the body, IRON deficiency, SINGLE nucleotide polymorphisms, GENES
Abstract

The 12th author's name is spelled incorrectly. The correct name is: Abdullah Hamadi.By Osama M. Al-Amer; Atif Abdulwahab A. Oyouni; Mohammed Ali Alshehri; Abdulrahman Alasmari; Othman R. Alzahrani; Saad Ali S. Aljohani; Noura Alasmael; Abdulrahman Theyab; Mohammad Algahtani; Hadeel Al Sadoun; Khalaf F. Alsharif; Abdullah Hamadi; Wed A. Abdali and Yousef MohammedRabaa HawasawiReported by Author; Author; Author; Author; Author; Author; Author; Author; Author; Author; Author; Author; Author; Author [Extracted from the article]

Published
2024
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33. Understanding the control of inclusion of SrO to the Li2O -K2O-B2O3-SrO glasses on the physical, structural, and gamma ray shielding performance.

Author

Laariedh, Farah, Sayyed, M. I., Alfadhli, S., Kumar, Ashok, Hamadi, Abdullah, Alatawi, Nada M., and Al-Hadeethi, Yas

Subjects
GAMMA rays, ATTENUATION coefficients, ATOMIC number, RADIATION protection
Abstract

The effect of the incorporation of the SrO to the Li2O -K2O-B2O3 glasses prepared through melt quenching technique has been studied. The density of the samples increases from 2.2057 to 2.8050 g/cm3. The XRD spectra reveals that the prepared samples are amorphous in nature. The five major bands having various IR peaks around 480 cm−1, 525 cm−1, 700 cm−1, 892 cm−1, 910 cm−1, 1225 cm−1, 1360 cm−1, and 1740 cm−1 are observed in the FTIR spectra. The gamma ray shielding properties have been calculated at several gamma-ray energies between 0.015 and 15 MeV using Phy-X software. LiKBSr20 with highest linear attenuation coefficient and effective atomic number is the best attenuator out of the fabricated LiKBSr-X glasses. The radiation protection efficiency (RPE) improves on addition of SrO and the RPE values indicate that these glasses can be developed as shielding glasses for the low-energy photons. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Adsorption of Azo Dyes from Textile Wastewater by Spirulina Platensis

Author

AL HAMADİ, Abdullah, URAZ, Güven, KATIRCIOĞLU, Hikmet, and OSMANAĞAOĞLU, Özlem

Subjects
Spirulina platensis,waste water,azo-dyes,textile industry, Biology, Biyoloji
Abstract

Due to the mushrooming of industrialactivities nowadays, the released contaminants have posed risks to thestability of ecological system. In particular, the mixture consisting ofcolourants used in the textile industry and water resources is detrimental tohuman health. In order to circumvent this problem, strategies such asprecipitation, membrane filtering, adsorption and electrochemical procedureshave been applied. It is commonly known that adsorption is economical,eco-friendly and easy to operate. In this study, microalg, which is a kind ofcyanobacteria (i.e. Spirulina plantensis), was used to eliminate azo-dyes from the aqueous solution viaadsorption. Microalg was tested at various conditions (i.e. pH, dyeconcentration, temperature, biomass amount and contact time). The removalpercentages of Acid Black 210 and Acid Blue 7 dyes byusing microalg biomass at pH=2 were 95.35 % and 92.56 %, respectively.Meanwhile, conditions such as 100 mg/L dye concentration and 0.5 g/L biomasswould lead to removal percentagesof 98.55 % and 97.05 % for AcidBlack 210 (60 minutes contact time) and Acid Blue 7 (75 minutes contact time),respectively. The spectrofotometric measurements show that adsorption methodhas a great potential for removing colourants in aqueous solutions. It couldserve as an alternative method for.

Published
2017

38. Spirulina platensis ve Chlorella vulgaris ile boyar madde giderimi

Author

Al Hamadi, Abdullah, Uraz, Güven, and Biyoloji Anabilim Dalı

Subjects
Biology, Biyoloji
Abstract

Sanayi ve teknolojinin artan hızla ilerlemesine bağlı olarak ekolojik sistemleri tehdit eden kirleticiler doğaya zarar vermektedir. Özellikle tekstil endüstrisinin kullandığı toksik boyar maddeler atık sularla birlikte diğer su ekosistemlerine karışmaktadır. Atık su sistemlerindeki bu problem yaratan kirleticilerin giderimini sağlamak için birçok yöntem kullanılmaktadır. Bu yöntemler içerisinde biyosorpsiyon işlemi diğer yöntemlere kıyasla daha kolay, daha ekonomik ve çevreye dost alternatif bir yöntemdir. Bu çalışmada Spirulina plantensis ve Chlorella vulgaris kuru biyokütlesi sulu çözelti içerisindeki farklı azo boyar maddelerinin (Acid Black 210, Acid Black 234, Acid Blue 113, Acid Blue 7 ve Acid Brown 349) biyosorpsiyon yöntemi ile gideriminde kullanılmıştır. Deneysel çalışmalar sonucunda boyar madde biyosorpsiyonu için S. platensis ve C. vulgaris biyokütlesinin optimum pH değeri 2 olarak belirlenmiştir. En uygun biyosorbent miktarı 0,5 g/ L olarak tespit edilmiştir. Boyar madde biyosorpsiyonuna boyar madde konsantrasyonunun etkisi incelendiğinde, her iki biyosorbent için boya konsantrasyonu artmasıyla giderim aktivitesinin arttığı gözlemlenmiştir. Ortam sıcaklığının boyar madde biyosorpsiyonuna etkisi incelendiğinde, sıcaklığın artmasıyla S. platensis adsorbenti için giderim verimi artarken, C. vulgaris adsorbenti için azalmıştır. Optimum sıcaklık değeri S. platensis için 60°C ve C. vulgaris için 30°C olarak belirlenmiştir. Spektrofotometrik ölçümler sonrası elde edilen sprektrum analizi, adsorbanın sulu çözelti içerisindeki boyar maddelerin giderimi için önemli bir potansiyele sahip olduğunu ortaya koymuştur. Owing to increasing industrial development, many technological contaminants threaten the ecological system and harm nature. In particular, toxic dye materials used in the textile industry often dissolve in other water resources when absorbed by waste water. Many procedures are used to counter this absorption. Biosorption is the easiest, most economical and environmentally-friendly of these. In this research, Spiralina plantensis and Chlorella vulgaris have both been used for the biosorption of different azo-dye materials (Acid black 210; Acid Black 234; Acid blue 113; Acid blue 7 and Acid brown 349) in the water solution. As a result of these experiments, the optimum pH for S. platensis ve C. vulgaris was determined as 2. The most suitable biosorbent amount was determined as 0,5 g/ L. When the effect of dye concentration on dye biosorption was examined, it was found that there was an increase in the removal process owing to increasing dye concentration when two biosorbent materials were used. The effect of temperature on dye biosorption increased with rising temperature for S. platensis and increased biosorption efficiency, whereas C. vulgaris decreases as temperatures increase. Optimum temperatures were determined for S. platensis and C. vulgaris as 60°C and 30°C respectively. Spectrum analysis obtained by spectofotometric measurements has shown that adsorbent has significant importance for the removal of dye materials in the aqueous solution. 137

Published
2017

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