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11. Clinical Evaluation of Cellulose Porous Beads for the Therapeutic Embolization of Meningiomas

Author

Kai, Y., Hamada, J.-I., Morioka, M., Yano, S., Nakamura, H., Makino, K., Mizuno, T., Takeshima, H., and Kuratsu, J.-I.

Subjects
Adult, Aged, 80 and over, Male, Interventional, Humans, Female, Middle Aged, Cellulose, Meningioma, Embolization, Therapeutic, Microspheres, Aged, Retrospective Studies
Abstract

BACKGROUND AND PURPOSE: Cellulose porous beads (CPBs) are a new, exceptionally uniformly sized, nonabsorbable embolic agent. We evaluated their efficacy in the preoperative embolization of meningiomas. METHODS: In 141 consecutive patients, we used CPBs (200-μm diameter) for the preoperative embolization of meningiomas. We selected patients whose tumors were ≥4 cm with 50% of blood to the tumor supplied by the external carotid artery (ECA). All patients underwent a provocation test before embolization. The percentage of blood supplied to the tumor by the internal carotid artery and ECA was determined angiographically. Nonenhanced areas on postembolization MR imaging were calculated. Intraoperative blood loss, units of blood transfusion, and hemostasis at the time of surgery were recorded for each patient. The interval between embolization and surgery was intentionally longer than 7 days. RESULTS: Of the 141 patients, 128 underwent CBP embolization. Eleven patients had positive provocation test results, and 2 had vasospasm; they were not CBP embolized. In 72% of the patients CBP embolization achieved reduction in the flow of the feeding artery by more than 50%. The nonenhanced area on MR imaging was not significantly correlated with the degree of ECA supply or devascularization. The interval between embolization and surgery was 8–26 days (mean, 9.9 days). The longer this interval, the greater was the tumor-softening effect and the rate of tumor removal. CONCLUSIONS: CPBs may be useful for the preoperative embolization of meningiomas. To increase the efficacy of CPB embolization, the interval to surgery should be at least 7 days.

Published
2006

12. STEM CELLS

Author

Cheng, L., primary, Huang, Z., additional, Zhou, W., additional, Wu, Q., additional, Rich, J., additional, Bao, S., additional, Baxter, P., additional, Mao, H., additional, Zhao, X., additional, Liu, Z., additional, Huang, Y., additional, Voicu, H., additional, Gurusiddappa, S., additional, Su, J. M., additional, Perlaky, L., additional, Dauser, R., additional, Leung, H.-c. E., additional, Muraszko, K. M., additional, Heth, J. A., additional, Fan, X., additional, Lau, C. C., additional, Man, T.-K., additional, Chintagumpala, M., additional, Li, X.-N., additional, Clark, P., additional, Zorniak, M., additional, Cho, Y., additional, Zhang, X., additional, Walden, D., additional, Shusta, E., additional, Kuo, J., additional, Sengupta, S., additional, Goel-Bhattacharya, S., additional, Kulkarni, S., additional, Cochran, B., additional, Cusulin, C., additional, Luchman, A., additional, Weiss, S., additional, Wu, M., additional, Fernandez, N., additional, Agnihotri, S., additional, Diaz, R., additional, Rutka, J., additional, Bredel, M., additional, Karamchandani, J., additional, Das, S., additional, Day, B., additional, Stringer, B., additional, Al-Ejeh, F., additional, Ting, M., additional, Wilson, J., additional, Ensbey, K., additional, Jamieson, P., additional, Bruce, Z., additional, Lim, Y. C., additional, Offenhauser, C., additional, Charmsaz, S., additional, Cooper, L., additional, Ellacott, J., additional, Harding, A., additional, Lickliter, J., additional, Inglis, P., additional, Reynolds, B., additional, Walker, D., additional, Lackmann, M., additional, Boyd, A., additional, Berezovsky, A., additional, Poisson, L., additional, Hasselbach, L., additional, Irtenkauf, S., additional, Transou, A., additional, Mikkelsen, T., additional, deCarvalho, A. C., additional, Emlet, D., additional, Del Vecchio, C., additional, Gupta, P., additional, Li, G., additional, Skirboll, S., additional, Wong, A., additional, Figueroa, J., additional, Shahar, T., additional, Hossain, A., additional, Lang, F., additional, Fouse, S., additional, Nakamura, J., additional, James, C. D., additional, Chang, S., additional, Costello, J., additional, Frerich, J. M., additional, Rahimpour, S., additional, Zhuang, Z., additional, Heiss, J. D., additional, Golebiewska, A., additional, Stieber, D., additional, Evers, L., additional, Lenkiewicz, E., additional, Brons, N. H. C., additional, Nicot, N., additional, Oudin, A., additional, Bougnaud, S., additional, Hertel, F., additional, Bjerkvig, R., additional, Barrett, M., additional, Vallar, L., additional, Niclou, S. P., additional, Hao, X., additional, Rahn, J., additional, Ujack, E., additional, Lun, X., additional, Cairncross, G., additional, Senger, D., additional, Robbins, S., additional, Harness, J., additional, Lerner, R., additional, Ihara, Y., additional, Santos, R., additional, Torre, J. D. L., additional, Lu, A., additional, Ozawa, T., additional, Nicolaides, T., additional, James, D., additional, Petritsch, C., additional, Higgins, D., additional, Schroeder, M., additional, Ball, B., additional, Milligan, B., additional, Meyer, F., additional, Sarkaria, J., additional, Henley, J., additional, Flavahan, W., additional, Hitomi, M., additional, Rahim, N., additional, Kim, Y., additional, Sloan, A., additional, Weil, R., additional, Nakano, I., additional, Li, M., additional, Lathia, J., additional, Hjelmeland, A., additional, Kaluzova, M., additional, Platt, S., additional, Kent, M., additional, Bouras, A., additional, Machaidze, R., additional, Hadjipanayis, C., additional, Kang, S.-G., additional, Kim, S.-H., additional, Huh, Y.-M., additional, Kim, E.-H., additional, Park, E.-K., additional, Chang, J. H., additional, Kim, S. H., additional, Hong, Y. K., additional, Kim, D. S., additional, Lee, S.-J., additional, Kim, E. H., additional, Kang, S. G., additional, Deleyrolle, L., additional, Sinyuk, M., additional, Goan, W., additional, Otvos, B., additional, Rohaus, M., additional, Oli, M., additional, Vedam-Mai, V., additional, Schonberg, D., additional, Lee, S.-T., additional, Chu, K., additional, Lee, S. K., additional, Kim, M., additional, Roh, J.-K., additional, Griveau, A., additional, Reichholf, B., additional, McMahon, M., additional, Rowitch, D., additional, Nitta, R., additional, Mitra, S., additional, Agarwal, M., additional, Bui, T., additional, Lin, J., additional, Adamson, C., additional, Martinez-Quintanilla, J., additional, Choi, S.-H., additional, Bhere, D., additional, Heidari, P., additional, He, D., additional, Mahmood, U., additional, Shah, K., additional, Gholamin, S., additional, Feroze, A., additional, Achrol, A., additional, Kahn, S., additional, Weissman, I., additional, Cheshier, S., additional, Sulman, E. P., additional, Wang, Q., additional, Mostovenko, E., additional, Liu, H., additional, Lichti, C. F., additional, Shavkunov, A., additional, Kroes, R. A., additional, Moskal, J. R., additional, Conrad, C. A., additional, Lang, F. F., additional, Emmett, M. R., additional, Nilsson, C. L., additional, Osuka, S., additional, Sampetrean, O., additional, Shimizu, T., additional, Saga, I., additional, Onishi, N., additional, Sugihara, E., additional, Okubo, J., additional, Fujita, S., additional, Takano, S., additional, Matsumura, A., additional, Saya, H., additional, Saito, N., additional, Fu, J., additional, Wang, S., additional, Yung, W. K. A., additional, Koul, D., additional, Schmid, R. S., additional, Irvin, D. M., additional, Vitucci, M., additional, Bash, R. E., additional, Werneke, A. M., additional, Miller, C. R., additional, Shinojima, N., additional, Takezaki, T., additional, Fueyo, J., additional, Gumin, J., additional, Gao, F., additional, Nwajei, F., additional, Marini, F. C., additional, Andreeff, M., additional, Kuratsu, J.-I., additional, Singh, S., additional, Burrell, K., additional, Koch, E., additional, Jalali, S., additional, Vartanian, A., additional, Sulman, E., additional, Wouters, B., additional, Zadeh, G., additional, Spelat, R., additional, Singer, E., additional, Matlaf, L., additional, McAllister, S., additional, Soroceanu, L., additional, Spiegl-Kreinecker, S., additional, Loetsch, D., additional, Laaber, M., additional, Schrangl, C., additional, Wohrer, A., additional, Hainfellner, J., additional, Marosi, C., additional, Pichler, J., additional, Weis, S., additional, Wurm, G., additional, Widhalm, G., additional, Knosp, E., additional, Berger, W., additional, Kuratsu, J.-i., additional, Tam, Q., additional, Tanaka, S., additional, Nakada, M., additional, Yamada, D., additional, Todo, T., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Hirao, A., additional, Tilghman, J., additional, Ying, M., additional, Laterra, J., additional, Venere, M., additional, Chang, C., additional, Summers, M., additional, Rosenfeld, S., additional, Luk, S., additional, Iafrate, J., additional, Cahill, D., additional, Martuza, R., additional, Rabkin, S., additional, Chi, A., additional, Wakimoto, H., additional, Wirsching, H.-G., additional, Krishnan, S., additional, Frei, K., additional, Krayenbuhl, N., additional, Reifenberger, G., additional, Weller, M., additional, Tabatabai, G., additional, Man, J., additional, Shoemake, J., additional, and Yu, J., additional

Published
2013
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17. LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY

Author

Yang, F. H., primary, Zhang, B., additional, Zhou, D. J., additional, Bie, L., additional, Tom, M. W., additional, Drummond, D. C., additional, Nicolaides, T., additional, Mueller, S., additional, Banerjee, A., additional, Park, J. W., additional, Prados, M. D., additional, James, D. C., additional, Gupta, N., additional, Hashizume, R., additional, Strohbehn, G. W., additional, Zhou, J., additional, Fu, M., additional, Patel, T. R., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Xie, Q., additional, Johnson, J., additional, Bradley, R., additional, Ascierto, M. L., additional, Kang, L., additional, Koeman, J., additional, Marincola, F. M., additional, Briggs, M., additional, Tanner, K., additional, Vande Woude, G. F., additional, Tanaka, S., additional, Klofas, L. K., additional, Wakimoto, H., additional, Borger, D. R., additional, Iafrate, A. J., additional, Batchelor, T. T., additional, Chi, A. S., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Rizk, E., additional, Harbaugh, K., additional, Connor, J. R., additional, Sarkar, G., additional, Curran, G. L., additional, Jenkins, R. B., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Fujii, K., additional, Ishida, J., additional, Shimazu, Y., additional, Date, I., additional, Ebsworth, K., additional, Walters, M. J., additional, Ertl, L. S., additional, Wang, Y., additional, Berahovich, R. D., additional, Zhang, P., additional, Powers, J. P., additional, Liu, S.-C., additional, Al Omran, R., additional, Sullivan, T. J., additional, Jaen, J. C., additional, Brown, M., additional, Schall, T. J., additional, Yusuke, N., additional, Shimizu, S., additional, Shishido-Hara, Y., additional, Shiokawa, Y., additional, Nagane, M., additional, Wang, J., additional, Sai, K., additional, Chen, F.-R., additional, Chen, Z.-P., additional, Shi, Z., additional, Zhang, J., additional, Zhang, K., additional, Han, L., additional, Chen, L., additional, Qian, X., additional, Zhang, A., additional, Wang, G., additional, Jia, Z., additional, Pu, P., additional, Kang, C., additional, Kong, L.-Y., additional, Doucette, T. A., additional, Ferguson, S. D., additional, Hachem, J., additional, Yang, Y., additional, Wei, J., additional, Priebe, W., additional, Fuller, G. N., additional, Qiao, W., additional, Rao, G., additional, Heimberger, A. B., additional, Chen, P.-Y., additional, Ozawa, T., additional, Drummond, D., additional, Santos, R., additional, Torre, J. D., additional, Ng, C., additional, Lepe, E. L., additional, Butowski, N., additional, Prados, M., additional, Bankiewicz, K., additional, James, C. D., additional, Cheng, Z., additional, Gong, Y., additional, Ma, Y., additional, Muller-Knapp, S., additional, Knapp, S., additional, Antonio Chiocca, E., additional, Kaur, B., additional, Yu, J. S., additional, Judkowski, V., additional, Bunying, A., additional, Ji, J., additional, Li, Z., additional, Bender, J., additional, Pinilla, C., additional, Srinivasan, V., additional, Dombovy-Johnson, M., additional, Carson-Walter, E., additional, Walter, K., additional, Xu, Z., additional, Popp, B., additional, Schlesinger, D., additional, Gray, L., additional, Sheehan, J., additional, Keir, S. T., additional, Friedman, H. S., additional, Bigner, D. D., additional, Kut, C., additional, Tyler, B., additional, McVeigh, E., additional, Li, X., additional, Herzka, D., additional, Grossman, S., additional, Lasky, J. L., additional, Panosyan, E., additional, Meisen, W. H., additional, Hardcastle, J., additional, Wojton, J., additional, Wohleb, E., additional, Alvarez-Breckenridge, C., additional, Nowicki, M., additional, Godbout, J., additional, Lee, S. Y., additional, Sheehan, J. M., additional, Yin, S., additional, Kaluz, S., additional, Devi, S. N., additional, de Noronha, R., additional, Nicolaou, K. C., additional, Van Meir, E. G., additional, Lachowicz, J. E., additional, Demeule, M., additional, Che, C., additional, Tripathy, S., additional, Jarvis, S., additional, Currie, J.-C., additional, Regina, A., additional, Nguyen, T., additional, Castaigne, J.-P., additional, Zielinska-Chomej, K., additional, Mohanty, C., additional, Viktorsson, K., additional, Lewensohn, R., additional, Driscoll, J. J., additional, Alsidawi, S., additional, Warnick, R. E., additional, Rixe, O., additional, deCarvalho, A. C., additional, Irtenkauf, S., additional, Hasselbach, L., additional, Xin, H., additional, Mikkelsen, T., additional, Sherman, J. H., additional, Siu, A., additional, Volotskova, O., additional, Keidar, M., additional, Gibo, D. M., additional, Dickinson, P., additional, Robertson, J., additional, Rossmeisl, J., additional, Debinski, W., additional, Nair, S., additional, Schmittling, R., additional, Boczkowski, D., additional, Archer, G., additional, Sampson, J. H., additional, Mitchell, D. A., additional, Miller, I. S., additional, Didier, S., additional, Murray, D. W., additional, Issaivanan, M., additional, Coniglio, S. J., additional, Segall, J. E., additional, Al-Abed, Y., additional, Symons, M., additional, Fotovati, A., additional, Hu, K., additional, Triscott, J., additional, Bacha, J., additional, Brown, D. M., additional, Dunn, S. E., additional, Daniels, D. J., additional, Peterson, T. E., additional, Dietz, A. B., additional, Knutson, G. J., additional, Parney, I. F., additional, Diaz, R. J., additional, Golbourn, B., additional, Picard, D., additional, Smith, C., additional, Huang, A., additional, Rutka, J., additional, Saito, N., additional, Fu, J., additional, Yao, J., additional, Wang, S., additional, Koul, D., additional, Yung, W. K. A., additional, Yuan, Y., additional, Sulman, E. P., additional, Colman, H., additional, Lang, F. F., additional, Slat, E. A., additional, Herzog, E. D., additional, Rubin, J. B., additional, Carminucci, A. S., additional, Amendolara, B., additional, Leung, R., additional, Lei, L., additional, Canoll, P., additional, Bruce, J. N., additional, Wojton, J. A., additional, Chu, Z., additional, Kwon, C.-H., additional, Chow, L. M., additional, Palascak, M., additional, Franco, R., additional, Bourdeau, T., additional, Thornton, S., additional, Qi, X., additional, Kitange, G. J., additional, Mladek, A. C., additional, Su, D., additional, Carlson, B. L., additional, Schroeder, M. A., additional, Pokorny, J. L., additional, Bakken, K. K., additional, Gupta, S. K., additional, Decker, P. A., additional, Wu, W., additional, Sarkaria, J. N., additional, Oddou, M. P., additional, Mollard, A., additional, Call, L. T., additional, Vakayalapati, H., additional, Warner, S. L., additional, Sharma, S., additional, Bearss, D. J., additional, Chen, T. C., additional, Cho, H., additional, Wang, W., additional, Hofman, F. M., additional, Flores, C. T., additional, Snyder, D., additional, Sanchez-Perez, L., additional, Pham, C., additional, Friedman, H., additional, Woolf, E., additional, Abdelwahab, M. G., additional, Turner, G., additional, Preul, M. C., additional, Lynch, A., additional, Rho, J. M., additional, Scheck, A. C., additional, Salphati, L., additional, Heffron, T. P., additional, Alicke, B., additional, Barck, K., additional, Carano, R. A., additional, Cheong, J., additional, Greve, J., additional, Lee, L. B., additional, Nishimura, M., additional, Pang, J., additional, Plise, E. G., additional, Reslan, H. B., additional, Zhang, X., additional, GOuld, S. G., additional, Olivero, A. G., additional, Phillips, H. S., additional, Zadeh, G., additional, Jalali, S., additional, Voce, D., additional, Wei, Z., additional, Shijun, K., additional, Nikolai, K., additional, Josh, W., additional, Clayton, C., additional, Bakhtiar, Y., additional, Alkins, R., additional, Burgess, A., additional, Ganguly, M., additional, Wels, W., additional, Hynynen, K., additional, Li, Y. M., additional, Jun, H., additional, Daniel, V., additional, Walter, H. A., additional, Nakashima, H., additional, Nguyen, T. T., additional, Shalkh, I., additional, Goins, W. F., additional, Chiocca, E. A., additional, Pyko, I. V., additional, Nakada, M., additional, Furuyama, N., additional, Lei, T., additional, Hayashi, Y., additional, Kawakami, K., additional, Minamoto, T., additional, Fedulau, A. S., additional, and Hamada, J.-i., additional

Published
2012
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18. NEUROSURGICAL TREATMENTS

Author

Nanney, A. D., primary, Adel, J. G., additional, Smith, T. R., additional, Chandler, J. P., additional, Kimmell, K. T., additional, Walter, K., additional, Zacharia, B. E., additional, Deibert, C., additional, Malone, H. R., additional, Sonabend, A. M., additional, Neugut, A. I., additional, Spencer, B., additional, Bruce, J. N., additional, Wang, Y., additional, Li, S., additional, Zhang, Z., additional, Chen, X., additional, You, G., additional, Yang, P., additional, Yan, W., additional, Bao, Z., additional, Yao, K., additional, Liu, Y., additional, Wang, L., additional, Jiang, T., additional, Farhoud, M. K., additional, Ruge, M. I., additional, Brandes, A. A., additional, Ermani, M., additional, Fioravanti, A., additional, Andreoli, A., additional, Pozzati, E., additional, Bacci, A., additional, Bartolini, S., additional, Poggi, R., additional, Crisi, G., additional, Franceschi, E., additional, Recinos, P. F., additional, Grabowski, M. M., additional, Nowacki, A. S., additional, Thompson, N., additional, Vogelbaum, M. A., additional, Sun, P., additional, Krueger, D., additional, Liu, Z., additional, Kohrman, M., additional, Dagens, A. B., additional, Rachinger, W., additional, Kunz, M., additional, Eigenbrod, S., additional, Lutz, J., additional, Tonn, J.-C., additional, Kreth, F.-W., additional, Duong, H. T., additional, Chaloner, C., additional, Bordo, G., additional, Eisenberg, A., additional, Rosenthal, K., additional, Sim, M.-S., additional, Boasberg, P., additional, Faries, M. B., additional, Hamid, O., additional, Kelly, D. F., additional, Thon, N., additional, Simon, M., additional, Westphal, M., additional, Schackert, G., additional, Nikkhah, G., additional, Hentschel, B., additional, Pietsch, T., additional, Reifenberger, G., additional, Weller, M., additional, Ironside, S., additional, Perry, J., additional, Tsao, M., additional, Mainprize, T., additional, Keith, J., additional, Laperrierre, N., additional, Paszat, L., additional, Sahgal, A., additional, Hoover, J. M., additional, Nwojo, M., additional, Puffer, R., additional, Parney, I. F., additional, Tanaka, S., additional, Nakada, M., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Lee, I. Y., additional, Ekram, T., additional, Jain, R., additional, Scarpace, L., additional, Omodon, M., additional, Rock, J., additional, Rosenblum, M., additional, Kalkanis, S., additional, Amankulor, N. M., additional, Kim, J.-H., additional, Tabar, V., additional, Peck, K. K., additional, Holodny, A. I., additional, Gutin, P. H., additional, Kim, C.-Y., additional, Kim, Y.-H., additional, Kim, T., additional, Kim, I. K., additional, Kim, J. W., additional, Kim, Y. H., additional, Han, J. H., additional, Park, C.-K., additional, Kim, D. G., additional, Jung, H.-W., additional, Nonaka, M., additional, Bamba, Y., additional, Kanemura, Y., additional, and Nakajima, S., additional

Published
2012
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19. RADIOLOGY

Author

Bluml, S., primary, Panigrahy, A., additional, Laskov, M., additional, Dhall, G., additional, Nelson, M. D., additional, Finlay, J. L., additional, Gilles, F. H., additional, Arita, H., additional, Kinoshita, M., additional, Kagawa, N., additional, Fujimoto, Y., additional, Hashimoto, N., additional, Yoshimine, T., additional, Hamilton, J. D., additional, Wang, J., additional, Levin, V. A., additional, Hou, P., additional, Loghin, M. E., additional, Gilbert, M. R., additional, Leeds, N. E., additional, deGroot, J. F., additional, Puduvalli, V., additional, Jackson, E. F., additional, Yung, W. K. A., additional, Kumar, A. J., additional, Ellingson, B. M., additional, Cloughesy, T. F., additional, Pope, W. B., additional, Zaw, T., additional, Phillips, H., additional, Lalezari, S., additional, Nghiemphu, P. L., additional, Ibrahim, H., additional, Motevalibashinaeini, K., additional, Lai, A., additional, Harris, R., additional, Douw, L., additional, Van de Nieuwenhuijzen, M. E., additional, Heimans, J. J., additional, Baayen, J. C., additional, Stam, C. J., additional, Reijneveld, J. C., additional, Juhasz, C., additional, Mittal, S., additional, Altinok, D., additional, Robinette, N. L., additional, Muzik, O., additional, Chakraborty, P. K., additional, Barger, G. R., additional, Zaw, T. M., additional, Goldin, J., additional, Chen, W., additional, Ahlman, M. A., additional, Giglio, P., additional, Kaufmann, T. J., additional, Anderson, S. K., additional, Jaeckle, K. A., additional, Uhm, J. H., additional, Northfelt, D. W., additional, Flynn, P. J., additional, Buckner, J. C., additional, Galanis, E., additional, Zalatimo, O., additional, Weston, C., additional, Allison, D., additional, Bota, D., additional, Kesari, S., additional, Glantz, M., additional, Sheehan, J., additional, Harbaugh, R. E., additional, Chiba, Y., additional, Tsuboi, A., additional, Hatazawa, J., additional, Sugiyama, H., additional, Nariai, T., additional, Toyohara, J., additional, Tanaka, Y., additional, Inaji, M., additional, Aoyagi, M., additional, Yamamoto, M., additional, Ishiwara, K., additional, Ohno, K., additional, Jalilian, L., additional, Essock-Burns, E., additional, Cha, S., additional, Chang, S., additional, Prados, M., additional, Butowski, N., additional, Nelson, S., additional, Kawahara, Y., additional, Nakada, M., additional, Hayashi, Y., additional, Kai, Y., additional, Uchiyama, N., additional, Kuratsu, J.-i., additional, Hamada, J.-i., additional, Yeom, K., additional, Rosenberg, J., additional, Andre, J. B., additional, Fisher, P. G., additional, Edwards, M. S., additional, Barnes, P. D., additional, Partap, S., additional, Lupo, J. M., additional, Crane, J. C., additional, Chang, S. M., additional, Nelson, S. J., additional, Romanowski, C. A., additional, Hoggard, N., additional, Jellinek, D. A., additional, Clenton, S., additional, McKevitt, F., additional, Wharton, S., additional, Craven, I., additional, Buller, A., additional, Waddle, C., additional, Bigley, J., additional, Wilkinson, I. D., additional, Metherall, P., additional, Eckel, L. J., additional, Keating, G. F., additional, Wetjen, N. M., additional, Giannini, C., additional, Wetmore, C., additional, Jain, R., additional, Narang, J., additional, Arbab, A. S., additional, Schultz, L., additional, Scarpace, L., additional, Mikkelsen, T., additional, Babajni-Feremi, A., additional, Poisson, L., additional, Gutman, D., additional, Jaffe, C., additional, Saltz, J., additional, Flanders, A., additional, Daniel, B., additional, Zach, L., additional, Guez, D., additional, Last, D., additional, Daniels, D., additional, Hoffman, C., additional, Mardor, Y., additional, Guha-Thakurta, N., additional, Debnam, J. M., additional, Kotsarini, C., additional, Jellinek, D., additional, Griffiths, P. D., additional, Khandanpour, N., additional, Bambrough, P., additional, Prabhu, S., additional, Bassett, R. L., additional, Yung, W. A., additional, Campen, C. J., additional, Soman, S., additional, Yeom, K. W., additional, Vos, M. J., additional, Berkhof, J., additional, Postma, T. J., additional, Sanchez, E., additional, Sizoo, E. M., additional, Lagerwaard, F. J., additional, Buter, J., additional, Noske, D. P., additional, Colen, R. R., additional, Mahajan, B., additional, Jolesz, F. A., additional, Zinn, P. O., additional, Molinaro, A., additional, Lawton, K., additional, Alexandru, D., additional, Linskey, M. E., additional, Chaumeil, M. M., additional, Gini, B., additional, Yang, H., additional, Iwanami, A., additional, Subramanian, S., additional, Ozawa, T., additional, Read, E. J., additional, Pieper, R. O., additional, Mischel, P., additional, James, C. D., additional, Ronen, S. M., additional, LaViolette, P. S., additional, Cochran, E., additional, Al-Gizawiy, M., additional, Connelly, J. M., additional, Malkin, M. G., additional, Rand, S. D., additional, Mueller, W. M., additional, Schmainda, K. M., additional, Cohen, A. D., additional, Prah, M., additional, Hartman, C. J., additional, Qiao, X. J., additional, He, R., additional, Brown, M., additional, and Cloughesy, T., additional

Published
2011
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20. -OMICS AND PROGNOSTIC MARKERS

Author

Moriera, F., primary, So, K., additional, Gould, P., additional, Kamnasaran, D., additional, Jensen, R. L., additional, Hussain, I., additional, Gutmann, D. H., additional, Gorovets, D., additional, Kastenhuber, E. R., additional, Pentsova, E., additional, Nayak, L., additional, Huse, J. T., additional, van den Bent, M. J., additional, Gravendeel, L. A., additional, Gorlia, T., additional, Kros, J. M., additional, Wesseling, P., additional, Teepen, J., additional, Idbaih, A., additional, Sanson, M., additional, Smitt, P. A. S., additional, French, P. J., additional, Zhang, W., additional, Zhang, J., additional, Hoadley, K., additional, Carter, B., additional, Li, S., additional, Kang, C., additional, You, Y., additional, Jiang, C., additional, Song, S., additional, Jiang, T., additional, Chen, C., additional, Grimm, C., additional, Weiler, M., additional, Claus, R., additional, Weichenhan, D., additional, Hartmann, C., additional, Plass, C., additional, Weller, M., additional, Wick, W., additional, Jenkins, R. B., additional, Sicotte, H., additional, Xiao, Y., additional, Fridley, B. L., additional, Decker, P. A., additional, Kosel, M. L., additional, Kollmeyer, T. M., additional, Fink, S. R., additional, Rynearson, A. L., additional, Rice, T., additional, McCoy, L. S., additional, Smirnov, I., additional, Tehan, T., additional, Hansen, H. M., additional, Patoka, J. S., additional, Prados, M. D., additional, Chang, S. M., additional, Berger, M. S., additional, Lachance, D. H., additional, Wiencke, J. K., additional, Wiemels, J. L., additional, Wrensch, M. R., additional, Gephart, M. H., additional, Lee, E., additional, Kyriazopoulou-Panagiotopoulou, S., additional, Milenkovic, L., additional, Xun, X., additional, Hou, Y., additional, Kui, W., additional, Edwards, M., additional, Batzoglou, S., additional, Jun, W., additional, Scott, M., additional, Hobbs, J. E., additional, Tipton, J., additional, Zhou, T., additional, Kelleher, N. L., additional, Chandler, J. P., additional, Schwarzenberg, J., additional, Czernin, J., additional, Cloughesy, T., additional, Ellingson, B., additional, Geist, C., additional, Phelps, M., additional, Chen, W., additional, Nakada, M., additional, Hayashi, Y., additional, Obuchi, W., additional, Ohtsuki, S., additional, Watanabe, T., additional, Ikeda, C., additional, Misaki, K., additional, Kita, D., additional, Uchiyama, N., additional, Terasaki, T., additional, Hamada, J.-i., additional, Hiddingh, L., additional, Tops, B., additional, Hulleman, E., additional, Kaspers, G.-J. L., additional, Vandertop, W. P., additional, Noske, D. P., additional, Wurdinger, T., additional, Jeuken, J. W., additional, See, A. P., additional, Hwang, T., additional, Shin, D., additional, Shin, J. H., additional, Gao, Y., additional, Lim, M., additional, Hutterer, M., additional, Michael, M., additional, Gerold, U., additional, Karin, S., additional, Ingrid, G., additional, Florian, D., additional, Armin, M., additional, Eugen, T., additional, Eberhard, G., additional, Gunther, S., additional, Cook, R. W., additional, Oelschlager, K., additional, Sevim, H., additional, Chung, L., additional, Wheeler, H. T., additional, Baxter, R. C., additional, McDonald, K. L., additional, Chaturbedi, A., additional, Yu, L., additional, Zhou, Y.-H., additional, Wong, A., additional, Fatuyi, R., additional, Linskey, M. E., additional, Lavon, I., additional, Shahar, T., additional, Zrihan, D., additional, Granit, A., additional, Ram, Z., additional, Siegal, T., additional, Brat, D. J., additional, Cooper, L. A., additional, Gutman, D. A., additional, Chisolm, C. S., additional, Appin, C., additional, Kong, J., additional, Kurc, T., additional, Van Meir, E. G., additional, Saltz, J. H., additional, Moreno, C. S., additional, Abuhusain, H. J., additional, Don, A. S., additional, Nagarajan, R. P., additional, Johnson, B. E., additional, Olshen, A. B., additional, Xie, M., additional, Wang, J., additional, Sundaram, V., additional, Paris, P., additional, Wang, T., additional, Costello, J. F., additional, Sijben, A. E., additional, Boots-Sprenger, S. H., additional, Boogaarts, J., additional, Rijntjes, J., additional, Geitenbeek, J. M., additional, van der Palen, J., additional, Bernsen, H. J., additional, Schnell, O., additional, Adam, S. A., additional, Eigenbrod, S., additional, Kretzschmar, H. A., additional, Tonn, J.-C., additional, Schuller, U., additional, Sperduto, P. W., additional, Kased, N., additional, Roberge, D., additional, Xu, Z., additional, Shanley, R., additional, Luo, X., additional, Sneed, P. K., additional, Chao, S. T., additional, Weil, R. J., additional, Suh, J., additional, Bhatt, A., additional, Jensen, A. W., additional, Brown, P. D., additional, Shih, H. A., additional, Kirkpatrick, J., additional, Gaspar, L. E., additional, Fiveash, J. B., additional, Chiang, V., additional, Knisely, J. P., additional, Sperduto, C. M., additional, Lin, N., additional, Mehta, M. P., additional, Kwatra, M. M., additional, Porter, T. M., additional, Brown, K. E., additional, Herndon, J. E., additional, Bigner, D. D., additional, Dahlrot, R. H., additional, Kristensen, B. W., additional, Hansen, S., additional, Sulman, E. P., additional, Cahill, D. P., additional, Wang, M., additional, Won, M., additional, Hegi, M. E., additional, Aldape, K. D., additional, Gilbert, M. R., additional, Sadr, E. S., additional, Tessier, A., additional, Sadr, M. S., additional, Alshami, J., additional, Sabau, C., additional, Del Maestro, R., additional, Neal, M. L., additional, Rockne, R., additional, Trister, A. D., additional, Swanson, K. R., additional, Maleki, S., additional, Back, M., additional, Buckland, M., additional, Brazier, D., additional, McDonald, K., additional, Cook, R., additional, Parker, N., additional, Wheeler, H., additional, Jalbert, L., additional, Elkhaled, A., additional, Phillips, J. J., additional, Yoshihara, H. A., additional, Parvataneni, R., additional, Srinivasan, R., additional, Bourne, G., additional, Cha, S., additional, Nelson, S. J., additional, Gilbert, M., additional, Cahill, D., additional, Hegi, M., additional, Colman, H., additional, Mehta, M., additional, Sulman, E., additional, Constantin, A., additional, Phillips, J., additional, Yoshihara, H., additional, Nelson, S., additional, Gunn, S., additional, Reveles, X. T., additional, Tirtorahardjo, B., additional, Strecker, M. N., additional, and Fichtel, L., additional

Published
2011
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23. Angiogenesis and Invasion

Author

Fishman, R. A., primary, Happ, E., additional, Stevens, T., additional, Kunschner, L., additional, Jaworski, D. M., additional, Stradecki, H. M., additional, Penar, P. L., additional, Pendlebury, W. W., additional, Pennington, C. J., additional, Edwards, D. R., additional, Broaddus, W. C., additional, Fillmore, H. L., additional, Mukherjee, J., additional, Hawkins, C., additional, Guha, A., additional, Pioli, P. D., additional, Milani, S., additional, Linskey, M. E., additional, Zhou, Y.-H., additional, Marchetti, V., additional, Barnett, F., additional, Wang, M., additional, Scheppke, L., additional, Sanchez-Cespedes, J., additional, De Rossi, C., additional, Nemerow, G., additional, Torbett, B., additional, Friedlander, M., additional, Goldlust, S. A., additional, Singer, S., additional, DeAngelis, L. M., additional, Lassman, A. B., additional, Nolan, C. P., additional, Yang, S.-H., additional, Lee, S. W., additional, Chen, Z.-p., additional, Liu, X.-m., additional, Wojton, J. A., additional, Chu, Z., additional, Qi, X., additional, Kaur, B., additional, Hu, Y., additional, Siegel, E., additional, Ro, D. I., additional, Marlon, S., additional, Hsu, N., additional, Milani, S. N., additional, Mohan, S., additional, Yu, L., additional, Hess, K. R., additional, Liu, Y., additional, Carson-Walter, E., additional, Walter, K., additional, Raghu, H., additional, Gondi, C. S., additional, Gujrati, M., additional, Dinh, D. H., additional, Rao, J. S., additional, Narayana, A., additional, Kunnakkat, S. D., additional, Medabalmi, P., additional, Golfinos, J., additional, Parker, E., additional, Knopp, E., additional, Zagzag, D., additional, Gruber, D., additional, Gruber, M. L., additional, Burrell, K., additional, Jelveh, S., additional, Lindsey, P., additional, Hill, R., additional, Zadeh, G., additional, Ivkovic, S., additional, Beadle, C., additional, Massey, S. C., additional, Swanson, K. R., additional, Canoll, P., additional, Rosenfeld, S. S., additional, McAllister, S., additional, Soroceanu, L., additional, Pakdel, A., additional, Limbad, C., additional, Adrados, I., additional, Desprez, P.-Y., additional, Nakada, M., additional, Nambu, E., additional, Furuyama, N., additional, Yoshida, Y., additional, Kita, D., additional, Hayashi, Y., additional, Hamada, J.-i., additional, Seyed Sadr, M., additional, Maret, D., additional, Seyed Sadr, E., additional, Siu, V., additional, Alshami, J., additional, Denault, J.-S., additional, Faury, D., additional, Jabado, N., additional, Nantel, A., additional, Del Maestro, R., additional, Perretta, D., additional, Nagaiah, G., additional, Almubarak, M., additional, Torres-Trejo, A., additional, Newton,, M., additional, Willey, P., additional, Altaha, R., additional, Murphy, S. F., additional, Banasiak, M., additional, Yee, G.-T., additional, Wotoczek-Obadia, M., additional, Tran, Y., additional, Prak, A., additional, Albright, R., additional, Mullan, M., additional, Paris, D., additional, Brem, S., additional, Yang, Y.-P., additional, Ennis, M., additional, Tran, N., additional, Symons, M., additional, Najbauer, J., additional, Huszthy, P. C., additional, Garcia, E., additional, Metz, M. Z., additional, Gutova, M., additional, Frank, R. T., additional, Miletic, H., additional, Glackin, C. A., additional, Barish, M. E., additional, Bjerkvig, R., additional, Aboody, K. S., additional, Clump, D. A., additional, Engh, J. A., additional, Mintz, A. H., additional, Cunnick, J., additional, Flynn, D. C., additional, Clark, A. J., additional, Butowski, N. A., additional, Chang, S. M., additional, Prados, M. D., additional, Clarke, J., additional, Polley, M.-Y. C., additional, Sughrue, M. E., additional, McDermott, M. W., additional, Parsa, A. T., additional, Berger, M. S., additional, Aghi, M. K., additional, Megyesi, J. F., additional, Costello, P., additional, Macdonald, W., additional, Dyer, E., additional, Macdonald, D., additional, Hammond, R., additional, Kalache, Y., additional, Easaw, J., additional, McIntyre, J., additional, Williams, S. C., additional, Karajannis, M. A., additional, Chiriboga, L., additional, von Deimling, A., additional, Ajlan, A., additional, Husaine, S., additional, Petrecca, K., additional, Magnus, N., additional, Garnier, D., additional, Meehan, B., additional, and Rak, J., additional

Published
2010
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27. A functional and quantitative mutational analysis of p53 mutations in yeast indicates strand biases and different roles of mutations in DMBA- and BBN-induced tumors in rats

Author

Yamamoto, K., primary, Nakata, D., additional, Tada, M., additional, Tonoki, H., additional, Nishida, T., additional, Hirai, A., additional, Ba, Y., additional, Aoyama, T., additional, Hamada, J.-I., additional, Furuuchi, K., additional, Harada, H., additional, Hirai, K., additional, Shibahara, N., additional, Katsuoka, Y., additional, and Moriuchi, T., additional

Published
2000
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38. Clinical evaluation of cellulose porous beads for the therapeutic embolization of meningiomas.

Author

Kai Y, Hamada JI, Morioka M, Yano S, Nakamura H, Makino K, Mizuno T, Takeshima H, and Kuratsu JI

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Meningioma surgery, Middle Aged, Retrospective Studies, Cellulose, Embolization, Therapeutic, Meningioma therapy, Microspheres
Abstract

Background and Purpose: Cellulose porous beads (CPBs) are a new, exceptionally uniformly sized, nonabsorbable embolic agent. We evaluated their efficacy in the preoperative embolization of meningiomas., Methods: In 141 consecutive patients, we used CPBs (200-microm diameter) for the preoperative embolization of meningiomas. We selected patients whose tumors were > or =4 cm with 50% of blood to the tumor supplied by the external carotid artery (ECA). All patients underwent a provocation test before embolization. The percentage of blood supplied to the tumor by the internal carotid artery and ECA was determined angiographically. Nonenhanced areas on postembolization MR imaging were calculated. Intraoperative blood loss, units of blood transfusion, and hemostasis at the time of surgery were recorded for each patient. The interval between embolization and surgery was intentionally longer than 7 days., Results: Of the 141 patients, 128 underwent CBP embolization. Eleven patients had positive provocation test results, and 2 had vasospasm; they were not CBP embolized. In 72% of the patients CBP embolization achieved reduction in the flow of the feeding artery by more than 50%. The nonenhanced area on MR imaging was not significantly correlated with the degree of ECA supply or devascularization. The interval between embolization and surgery was 8-26 days (mean, 9.9 days). The longer this interval, the greater was the tumor-softening effect and the rate of tumor removal., Conclusions: CPBs may be useful for the preoperative embolization of meningiomas. To increase the efficacy of CPB embolization, the interval to surgery should be at least 7 days.

Published
2006

39. A nonadhesive liquid embolic agent of ethylene vinyl alcohol copolymer and ethanol mixture for cerebral arteriovenous malformations. Clinical experience.

Author

Hamada JI, Kai Y, Mizuno T, Morioka M, Kazekawa K, Iwata H, and Ushio Y

Abstract

Summary: We report our experience using our new nonadhesive liquid embolic agent, an ethylene vinyl alcohol copolymer (EVAL)/Ethanol mixture, to treat human arteriovenous malformations (AVM). Between June 1995 and April 2001, 57 patients with confirmed AVM underwent embolization with the EVAL/Ethanol mixture. Using 87 procedures consisting of one to three stages, we embolized 185 feeding arteries to occlude as much of the AVM as possible. Repeated injections under fluoroscopic control could be performed smoothly without encountering cementing of the catheter in the vessel wall. Among 87 procedures undertaken in 57 patients, seven (8.0%) procedures in six patients produced new postembolization symptoms. Resolution of these symptoms occurred within hours or days following four of the seven procedures; permanent neurological deficits remained after three embolization procedures (3.4%). Of the 57 patients, three underwent postembolization radiosurgery, 54 were radically treated with microsurgical extirpation. Histopathological examinations of the 54 specimens disclosed mild inflammation within the embolized lumen without inflammatory reactions in the media or adventitia. Follow-up angiograms obtained three years after they underwent radiosurgery showed that in all three patients the nidus had completely disappeared. The EVAL/Ethanol mixture is handled easily and appears to be an effective and safe embolic agent for the preoperative embolization of AVM.

Published
2004
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40. Expression of neuron specific phosphatase, striatal enriched phosphatase (STEP) in reactive astrocytes after transient forebrain ischemia.

Author

Hasegawa S, Morioka M, Goto S, Korematsu K, Okamura A, Yano S, Kai Y, Hamada JI, and Ushio Y

Subjects
Animals, Blotting, Western, Cell Count, Dentate Gyrus blood supply, Dentate Gyrus enzymology, Enzyme Induction, Fluorescent Antibody Technique, Indirect, Gerbillinae, Glial Fibrillary Acidic Protein analysis, Gliosis enzymology, Gliosis pathology, Hippocampus blood supply, Ischemic Attack, Transient genetics, Male, Nerve Degeneration, Nerve Tissue Proteins genetics, Nerve Tissue Proteins physiology, Phosphorylation, Phosphotyrosine metabolism, Prosencephalon blood supply, Protein Processing, Post-Translational, Protein Tyrosine Phosphatases biosynthesis, Protein Tyrosine Phosphatases genetics, Protein Tyrosine Phosphatases physiology, Astrocytes enzymology, Hippocampus enzymology, Ischemic Attack, Transient enzymology, Nerve Tissue Proteins biosynthesis, Prosencephalon enzymology
Abstract

We studied the distribution and change of striatal enriched phosphatase (STEP) in the gerbil hippocampus after transient forebrain ischemia. STEP was expressed in the perikarya and in neuronal processes; it was not detected in non-neuronal cells of control animals. After 5-min forebrain ischemia, STEP immunoreactivity (STEP-IR) was preserved for 2 days; it disappeared 4 and more days after ischemia with completion of delayed neuronal death (DND) in the CA1 subfield. Furthermore, only in the CA1 after ischemia, STEP was expressed in reactive astrocytes for 4 to 28 days, showing different patterns of glial fibrillary acidic protein (GFAP)-positive reactive astrocytes. After non-or less-than lethal ischemia, STEP expression in reactive astrocytes corresponded with the degree of neuronal degeneration. Immunoblot analysis of the CA1 subfield revealed the expression of three isoforms, STEP45, -56 and -61; their expression patterns changed with time after ischemia. These data suggest that neuronal STEP is preserved until cell degeneration after ischemia and that STEP is expressed in reactive astrocytes only after lethal ischemia, with different expression patterns for its isoforms. Of STEP45, -56 and -61, STEP61 was the most strongly expressed in the reactive astrocytes; both STEP45 and -61 were expressed in neurons and the expression of STEP56 was weak. STEP may play an important role not only in neurons but also in reactive astrocytes after ischemia, depending on neuronal degeneration., (Copyright 2000 Wiley-Liss, Inc.)

Published
2000

41. Protein kinase C mediates the signal for interferon-gamma mRNA expression in cytotoxic T cells after their adhesion to laminin.

Author

Li YQ, Kobayashi M, Yuan L, Wang J, Matsushita K, Hamada JI, Kimura K, Yagita H, Okumura K, and Hosokawa M

Subjects
Animals, Antibodies, Monoclonal pharmacology, Antigens, CD immunology, Blotting, Western, Cell Adhesion immunology, Cell Line, Extracellular Matrix Proteins metabolism, Integrin alpha6, Integrin alpha6beta1, Integrins metabolism, Interferon-gamma genetics, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Naphthalenes pharmacology, Polymerase Chain Reaction, Protein Kinase C antagonists & inhibitors, RNA, Messenger genetics, Receptors, Laminin metabolism, Signal Transduction drug effects, T-Lymphocytes, Cytotoxic drug effects, T-Lymphocytes, Cytotoxic metabolism, Tetradecanoylphorbol Acetate pharmacology, Tumor Necrosis Factor-alpha metabolism, Interferon-gamma biosynthesis, Laminin metabolism, Protein Kinase C immunology, Signal Transduction immunology, T-Lymphocytes, Cytotoxic immunology
Abstract

A cytotoxic T-cell line, CTLL-2 cells, showed spreading after adhering to extracellular matrix proteins such as fibronectin (FN), laminin (LN) and hyarulonic acid (HA). The adhesion of CTLL-2 cells to LN was mediated by very late activation antigen-6 (VLA-6). Expression of interferon-gamma (IFN-gamma) mRNA was enhanced in CTLL-2 cells, also when they adhered to extracellular matrix proteins; and the enhanced IFN-gamma mRNA expression by adhering to LN was blocked by anti-alpha 6 antibody. Calphostin C, a protein kinase C (PKC) inhibitor, markedly inhibited the enhancement of IFN-gamma mRNA expression in a dose-dependent manner, which suggested that PKC acted as a second messenger in the IFN-gamma mRNA expression mediated by the interaction of VLA-6 with LN in CTLL-2 cells. Furthermore, confocal laser-microscopic analysis and Western blot analysis revealed that PKC-alpha was activated after CTLL-2 cells adhered to LN. PKC activity translocated from the cytosol fraction to the particulate fraction, after CTLL-2 cells adhered to LN. Altogether, we suggest that PKC plays an important role in the signal transduction for IFN-gamma mRNA expression after cytotoxic T cells adhere to LN.

Published
1998
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42. Clinical features of moyamoya disease in sibling relations under 15 years of age.

Author

Hamada JI, Yoshioka S, Nakahara T, Marubayashi T, and Ushio Y

Subjects
Adolescent, Cerebral Arteries pathology, Cerebral Revascularization, Child, Child, Preschool, Disease Progression, Family Health, Female, Follow-Up Studies, Humans, Ischemic Attack, Transient complications, Japan, Magnetic Resonance Angiography, Male, Severity of Illness Index, Treatment Outcome, Moyamoya Disease complications, Moyamoya Disease genetics, Moyamoya Disease pathology, Moyamoya Disease physiopathology, Moyamoya Disease surgery, Nuclear Family
Abstract

This study was undertaken to define the clinical features of moyamoya disease in sibling relations less than 15 years of age. We analysed five pairs of siblings (6 boys, 4 girls) with moyamoya disease from among 56 moyamoya patients less than 15 years of age. Of 56 paediatric patients with moyamoya disease, 5 were sibling pairs. At onset of the disease, all patients were under 10 years of age. Clinical manifestations in the proband and the affected sibling tended to present as transient ischaemic attacks; none of the 10 patients presented with intracranical haemorrhage. The probands were not always the older sibling, however, the time lapse between disease onset in the proband and his/her sibling was less than one year. Among the sibling pairs, there was no striking difference in disease staging based on angiographic findings. The incidence of sibling occurrence of moyamoya disease appears to be higher than previously assumed and the family of children with moyamoya disease should be cautioned that their other children have an increased risk of developing the illness.

Published
1998
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43. Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma.

Author

Nakayama N, Kashiwazaki H, Kobayashi N, Hamada JI, Ogiso Y, Itakura Y, Matsumoto K, Nakamura T, Koike T, Kuzumaki N, and Takeichi N

Subjects
Animals, Carcinoma, Hepatocellular pathology, Female, Hepatitis, Animal pathology, Hepatocyte Growth Factor blood, Hepatocyte Growth Factor genetics, Immunohistochemistry, Liver Neoplasms pathology, Male, Proto-Oncogene Proteins c-met, RNA, Messenger metabolism, Rats, Rats, Inbred Strains genetics, Receptor Protein-Tyrosine Kinases genetics, Carcinoma, Hepatocellular metabolism, Hepatitis, Animal genetics, Hepatitis, Animal metabolism, Hepatocyte Growth Factor pharmacology, Liver Neoplasms metabolism, Receptor Protein-Tyrosine Kinases metabolism
Abstract

The Long-Evans Cinnamon (LEC) rat is characterized by the spontaneous onset of acute and chronic hepatitis, followed by occurrence of liver cancer, and is thus able to provide a unique experimental model for human genetical liver disease, Wilson's disease. Hepatocyte growth factor (HGF) is a potent hepatotrophic factor in liver regeneration, and its expression is up-regulated in response to liver injuries. We found that the plasma HGF level in LEC rats rose markedly during the fulminant hepatitis phase, fell during the phase of chronic/cholangiofibrosis, and fluctuated during the hepatoma phase. Immunohistological staining of the liver revealed that the number of HGF-positive cells increased remarkably during the fulminant hepatitis phase, and that many of these cells were localized at the portal triads. Fewer HGF-positive cells were observed during the phase of chronic hepatitis. The surface of the hepatocellular carcinoma (HCC) cells and the cytoplasm of the nonepithelial cells in cancerous liver tissues were HGF-positive. The HGF-messenger RNA (mRNA) level in the liver rose in the fulminant hepatitis phase, fell in the chronic hepatitis phase, and was intermediate or high during the hepatoma phase. The expression of c-met mRNA was strong in the tissues of LEC rats with fulminant hepatitis and, especially, in the cholangiofibrosis tissues. c-met mRNA was also detected in HCCs. These results suggest that the HGF-c-met system may play an important role in the regeneration of hepatocytes as well as in the development of HCC in paracrine or autocrine mechanisms.

Published
1996
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