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Study region: The El-Kharga Oasis in the Western Desert of Egypt is selected as the study area due to its hyberarid climate condition and water scarcity. In this region, the fossil groundwater is the main water source; therefore, preserving groundwater quality and quantity is mandatory. Study focus: This study evaluated groundwater suitability for irrigation purposes and assessed the water requirements of cultivated crops to optimize the water supply in hyperarid climate regions. In total, 79 deep groundwater samples were hydrochemically tested to determine the suitability for irrigation by assessing the key water quality parameters. Spatial distribution maps of all chemical parameters, such as pH, EC, SAR, RSC, SSP, TDS, total hardness, Na+, K+, Ca++, Mg++, Fe, Mn, Cl-, and SO4—, were developed. The FAO CROPWAT 8.0 model, based on the Penman–Monteith equation, was used to forecast agricultural water requirements for three years, 2010, 2011, and 2012. New hydrological insights for the region: The groundwater had medium salinity and low sodium in 84% of the cases. In comparison, high salinity was found in 16% of the samples, indicating that groundwater can be used for many soil types with a low risk of exchangeable sodium. Except for 15 of the 79 wells, all groundwater samples had chloride concentrations less than 100 mg/l. The sulfate ion distribution map showed a low sulfate ion content in the extreme western south. The total annual irrigation water requirements of all crops for 2010, 2011 and 2012 were 199.4, 215.1, and 231.7 million m3/year, respectively, reflecting a gradual increase of approximately 16.57 million m3/total area/year due to the expansion of the cultivated area. The analysis showed that modern irrigation systems reduced the amount of irrigation water by 32% and increased the cultivated area by 45% compared to conventional irrigation methods. Severe groundwater depletion occurred during the dry season from March to July, which exacerbated the water