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386 results on '"Halmos, Gyorgy B."'

6. Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

Author

Matos, Leandro L., Sanabria, Alvaro, Robbins, K. Thomas, Halmos, Gyorgy B., Strojan, Primož, Ng, Wai Tong, Takes, Robert P., Angelos, Peter, Piazza, Cesare, de Bree, Remco, Ronen, Ohad, Guntinas-Lichius, Orlando, Eisbruch, Avraham, Zafereo, Mark, Mäkitie, Antti A., Shaha, Ashok R., Coca-Pelaz, Andres, Rinaldo, Alessandra, Saba, Nabil F., Cohen, Oded, Lopez, Fernando, Rodrigo, Juan P., Silver, Carl E., Strandberg, Timo E., Kowalski, Luiz Paulo, and Ferlito, Alfio

Published
2023
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9. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

Author

de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A. H. J., Schepman, Kees-Pieter, Hooghiemstra, Wouter T. R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E. C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., and Witjes, Max J. H.

Published
2023
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17. Decisional Conflict in Patients with Advanced Laryngeal Carcinoma: A Multicenter Study

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Heirman, Anne N., de Kort, Daan P., Petersen, Japke F., Al-Mamgani, Abrahim, Eerenstein, Simone E.J., de Kleijn, Bertram J., Hoebers, Frank, Tijink, Bernard M., Stuiver, Martijn M., van der Molen, Lisette, Dirven, Richard, Halmos, Gyorgy B., van den Brekel, Michiel W.M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, Heirman, Anne N., de Kort, Daan P., Petersen, Japke F., Al-Mamgani, Abrahim, Eerenstein, Simone E.J., de Kleijn, Bertram J., Hoebers, Frank, Tijink, Bernard M., Stuiver, Martijn M., van der Molen, Lisette, Dirven, Richard, Halmos, Gyorgy B., and van den Brekel, Michiel W.M.

Published
2024

18. The development of a decision aid for patients with operable oropharyngeal carcinoma in the Netherlands - A mixed methods study

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Heirman, Anne N, Dirven, Richard, van der Molen, Lisette, Schreuder, Willem H, Hoebers, Frank, Honings, Jimmie, Al-Mamgani, Abrahim, de Bree, Remco, Eerenstein, Simone E J, Halmos, Gyorgy B, van den Brekel, Michiel W M, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Heirman, Anne N, Dirven, Richard, van der Molen, Lisette, Schreuder, Willem H, Hoebers, Frank, Honings, Jimmie, Al-Mamgani, Abrahim, de Bree, Remco, Eerenstein, Simone E J, Halmos, Gyorgy B, and van den Brekel, Michiel W M

Published
2024

21. Decisional Conflict in Patients with Advanced Laryngeal Carcinoma: A Multicenter Study.

Author

Heirman, Anne N., de Kort, Daan P., Petersen, Japke F., Al‐Mamgani, Abrahim, Eerenstein, Simone E.J., de Kleijn, Bertram J., Hoebers, Frank, Tijink, Bernard M., Stuiver, Martijn M., van der Molen, Lisette, Dirven, Richard, Halmos, Gyorgy B., and van den Brekel, Michiel W.M.

Abstract

Objectives: Decision‐making for patients with a locally advanced laryngeal carcinoma (T3 and T4) is challenging due to the treatment choice between organ preservation and laryngectomy, both with different and high impact on function and quality of life (QoL). The complexity of these treatment decisions and their possible consequences might lead to decisional conflict (DC). This study aimed to explore the level of DC in locally advanced laryngeal carcinoma patients facing curative decision‐making, and to identify possible associated factors. Methods: In this multicenter prospective cohort study, participants completed questionnaires on DC, level of shared decision‐making (SDM), and a knowledge test directly after counseling and 6 months after treatment. Descriptive statistics and Spearman correlation tests were used to analyze the data. Results: Directly after counseling, almost all participants (44/45; 98%) experienced Clinically Significant DC score (CSDC >25, scale 0–100). On average, patients scored 47% (SD 20%) correct on the knowledge test. Questions related to radiotherapy were answered best (69%, SD 29%), whilst only 35% (SD 29%) of the questions related to laryngectomy were answered correctly. Patients' perceived level of SDM (scale 0–100) was 70 (mean, SD 16.2), and for physicians this was 70 (SD 1.7). Conclusion: Most patients with advanced larynx cancer experience high levels of DC. Low knowledge levels regarding treatment aspects indicate a need for better patient counseling. Level of Evidence: 4 Laryngoscope, 134:3604–3610, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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22. Narrow band imaging reveals field cancerisation undetected by conventional white light: Optical diagnosis versus histopathology.

Author

Westra, Jeroen M., Zwakenberg, Manon A., Halmos, Gyorgy B., van der Laan, Bernard F. A. M., van der Vegt, Bert, and Plaat, Boudewijn E. C.

Subjects
HISTOPATHOLOGY, DIAGNOSIS
Abstract

Objective: To assess whether narrow band imaging (NBI) detects fields of cancerisation around suspicious lesions in the upper aerodigestive tract, which were undetected by white light imaging (WLI). Methods: In 96 patients with laryngeal and pharyngeal lesions suspicious for malignancy, 206 biopsies were taken during laryngoscopy: 96 biopsies of suspicious lesions detected by both WLI and NBI (WLI+/NBI+), 60 biopsies adjacent mucosa only suspicious with NBI (WLI‐/NBI+), and 46 biopsies of NBI and WLI unsuspicious mucosa (WLI‐/NBI‐) as negative controls. Optical diagnosis according to the Ni‐classification was compared with histopathology. Results: Signs of (pre)malignancy were found in 88% of WLI+/NBI+ biopsies, 32% of WLI‐/NBI+ biopsies and 0% in WLI‐/NBI‐ (p <.001). In 58% of the WLI‐/NBI+ mucosa any form of dysplasia or carcinoma was detected. Conclusion: The use of additional NBI led to the detection of (pre)malignancy in 32% of the cases, that would have otherwise remained undetected with WLI alone. This highlights the potential of NBI as a valuable adjunct to WLI in the identification of suspicious lesions in the upper aerodigestive tract. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The influence of clinical experience on reliable evaluation of pharyngeal and laryngeal lesions: comparison of high-definition laryngoscopy using narrow band imaging with fibre-optic laryngoscopy.

Author

Scholman, Constanze, Zwakenberg, Manon A, Wedman, Jan, Wachters, Jan E, Halmos, Gyorgy B, van der Laan, Bernard F A M, and Plaat, Boudewijn E C

Subjects
LARYNGEAL diseases, DIAGNOSTIC imaging, RESEARCH evaluation, WORK experience (Employment), LARYNX, RETROSPECTIVE studies, DESCRIPTIVE statistics, ENDOSCOPIC surgery, FIBER optics, LARYNGOSCOPY, PHARYNGEAL diseases, PHARYNX, MEDICAL records, ACQUISITION of data, COMPARATIVE studies, MEDICAL referrals, ENDOSCOPY, INTER-observer reliability, SENSITIVITY & specificity (Statistics), EVALUATION
Abstract

Background: Fibre-optic laryngoscopy is still widely used in daily clinical practice; however, high-definition laryngoscopy using narrow band imaging could be more reliable in characterising pharyngeal and laryngeal lesions. Methods: Endoscopic videos were assessed in a tertiary referral hospital by 12 observers with different levels of clinical experience. Thirty pairs of high-definition laryngoscopy with narrow band imaging and fibre-optic laryngoscopy videos were judged twice, with an interval of two to four weeks, in a random order. Inter- and intra-observer reliability, sensitivity and specificity were calculated in terms of detecting a malignant lesion and a specific histological entity, for beginners, trained observers and experts. Results: Using high-definition laryngoscopy with narrow band imaging, inter-observer reliability for detecting malignant lesions increased from moderate to substantial in trained observers and experts (high-definition laryngoscopy with narrow band imaging κ = 0.66 and κ = 0.77 vs fibre-optic laryngoscopy κ = 0.51 and κ = 0.56, for trained observers and experts respectively) and sensitivity increased by 16 per cent. Conclusion: Inter-observer reliability increased with the level of clinical experience, especially when using high-definition laryngoscopy with narrow band imaging. [ABSTRACT FROM AUTHOR]

Published
2024
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37. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients:a phase II trial

Author

de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A.H.J., Schepman, Kees Pieter, Hooghiemstra, Wouter T.R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E.C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., Witjes, Max J.H., de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A.H.J., Schepman, Kees Pieter, Hooghiemstra, Wouter T.R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E.C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., and Witjes, Max J.H.

Abstract

Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery. Fluorescence molecular imaging (FMI) has been explored for intraoperative margin assessment, but data are limited to phase-I studies. In this single-arm phase-II study (NCT03134846), our primary endpoints were to determine the sensitivity, specificity and positive predictive value of cetuximab-800CW for tumor-positive margins detection. Secondary endpoints were safety, close margin detection rate and intrinsic cetuximab-800CW fluorescence. In 65 patients with 66 tumors, cetuximab-800CW was well-tolerated. Fluorescent spots identified in the surgical margin with signal-to-background ratios (SBR) of ≥2 identify tumor-positive margins with 100% sensitivity, 85.9% specificity, 58.3% positive predictive value, and 100% negative predictive value. An SBR of ≥1.5 identifies close margins with 70.3% sensitivity, 76.1% specificity, 60.5% positive predictive value, and 83.1% negative predictive value. Performing frozen section analysis aimed at the fluorescent spots with an SBR of ≥1.5 enables safe, intraoperative adjustment of surgical margins.

Published
2023

38. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

Author

Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, de Wit, Jaron G, Vonk, Jasper, Voskuil, Floris J, de Visscher, Sebastiaan A H J, Schepman, Kees-Pieter, Hooghiemstra, Wouter T R, Linssen, Matthijs D, Elias, Sjoerd G, Halmos, Gyorgy B, Plaat, Boudewijn E C, Doff, Jan J, Rosenthal, Eben L, Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B, van Dam, Gooitzen M, Witjes, Max J H, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, de Wit, Jaron G, Vonk, Jasper, Voskuil, Floris J, de Visscher, Sebastiaan A H J, Schepman, Kees-Pieter, Hooghiemstra, Wouter T R, Linssen, Matthijs D, Elias, Sjoerd G, Halmos, Gyorgy B, Plaat, Boudewijn E C, Doff, Jan J, Rosenthal, Eben L, Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B, van Dam, Gooitzen M, and Witjes, Max J H

Published
2023

39. Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Matos, Leandro L, Sanabria, Alvaro, Robbins, K Thomas, Halmos, Gyorgy B, Strojan, Primož, Ng, Wai Tong, Takes, Robert P, Angelos, Peter, Piazza, Cesare, de Bree, Remco, Ronen, Ohad, Guntinas-Lichius, Orlando, Eisbruch, Avraham, Zafereo, Mark, Mäkitie, Antti A, Shaha, Ashok R, Coca-Pelaz, Andres, Rinaldo, Alessandra, Saba, Nabil F, Cohen, Oded, Lopez, Fernando, Rodrigo, Juan P, Silver, Carl E, Strandberg, Timo E, Kowalski, Luiz Paulo, Ferlito, Alfio, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Matos, Leandro L, Sanabria, Alvaro, Robbins, K Thomas, Halmos, Gyorgy B, Strojan, Primož, Ng, Wai Tong, Takes, Robert P, Angelos, Peter, Piazza, Cesare, de Bree, Remco, Ronen, Ohad, Guntinas-Lichius, Orlando, Eisbruch, Avraham, Zafereo, Mark, Mäkitie, Antti A, Shaha, Ashok R, Coca-Pelaz, Andres, Rinaldo, Alessandra, Saba, Nabil F, Cohen, Oded, Lopez, Fernando, Rodrigo, Juan P, Silver, Carl E, Strandberg, Timo E, Kowalski, Luiz Paulo, and Ferlito, Alfio

Published
2023

40. Radiomics in Hypopharyngeal Cancer Management: A State-of-the-Art Review

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Chiesa-Estomba, Carlos M, Mayo-Yanez, Miguel, Guntinas-Lichius, Orlando, Vander-Poorten, Vincent, Takes, Robert P, de Bree, Remco, Halmos, Gyorgy B, Saba, Nabil F, Nuyts, Sandra, Ferlito, Alfio, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Chiesa-Estomba, Carlos M, Mayo-Yanez, Miguel, Guntinas-Lichius, Orlando, Vander-Poorten, Vincent, Takes, Robert P, de Bree, Remco, Halmos, Gyorgy B, Saba, Nabil F, Nuyts, Sandra, and Ferlito, Alfio

Published
2023

45. Radiomics in Hypopharyngeal Cancer Management: A State-of-the-Art Review

Author

Chiesa-Estomba, Carlos M., primary, Mayo-Yanez, Miguel, additional, Guntinas-Lichius, Orlando, additional, Vander-Poorten, Vincent, additional, Takes, Robert P., additional, de Bree, Remco, additional, Halmos, Gyorgy B., additional, Saba, Nabil F., additional, Nuyts, Sandra, additional, and Ferlito, Alfio, additional

Published
2023
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