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4. Cleaning up corruption

Author

Hallett, Michael, CDR

Subjects
INTERNATIONAL COOPERATION, AFGHANISTAN CRISIS, 2001- - Postwar Reconstruction, SECURITY, NATIONAL - Afghanistan - Study and Teaching, ETHICS - Standards
Abstract

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Published
2009

8. THE MAXIMUM-SECURITY SEMINARY: IF EVANGELICALS ARE COMPLICIT IN AMERICAS BROKEN PRISON SYSTEM, THEIR EDUCATION MINISTRIES ARE ONE OF ITS FEW BRIGHT SPOTS

Author

Hallett, Michael and Johnson, Byron R.

Subjects
Worship programs -- Forecasts and trends, Prisoners -- Religious aspects, Correctional institutions -- Religious aspects -- Forecasts and trends, Evangelical Christians -- Forecasts and trends, Market trend/market analysis, Philosophy and religion
Abstract

The most prominent evangelical mascot for prison ministry in recent memory is, of course, Charles 'Chuck' Colson. Known to many as Richard Nixon's 'hatchet man,' Colson later served time in [...]

Published
2021

17. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.

Author

Cyr-Depauw, Chanèle, Northey, Jason, Tabariès, Sébastien, Annis, Matthew, Dong, Zhifeng, Cory, Sean, Hallett, Michael, Rennhack, Jonathan, Andrechek, Eran, and Siegel, Peter

Subjects
Bone Morphogenetic Protein 4, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Culture Media, Conditioned, Eye Proteins, Female, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Invasiveness, Nerve Tissue Proteins, Prognosis, Transforming Growth Factor beta, Up-Regulation
Abstract

ShcA is an important mediator of ErbB2- and transforming growth factor β (TGF-β)-induced breast cancer cell migration, invasion, and metastasis. We show that in the context of reduced ShcA levels, the bone morphogenetic protein (BMP) antagonist chordin-like 1 (Chrdl1) is upregulated in numerous breast cancer cells following TGF-β stimulation. BMPs have emerged as important modulators of breast cancer aggressiveness, and we have investigated the ability of Chrdl1 to block BMP-induced increases in breast cancer cell migration and invasion. Breast cancer-derived conditioned medium containing elevated concentrations of endogenous Chrdl1, as well as medium containing recombinant Chrdl1, suppresses BMP4-induced signaling in multiple breast cancer cell lines. Live-cell migration assays reveal that BMP4 induces breast cancer migration, which is effectively blocked by Chrdl1. We demonstrate that BMP4 also stimulated breast cancer cell invasion and matrix degradation, in part, through enhanced metalloproteinase 2 (MMP2) and MMP9 activity that is antagonized by Chrdl1. Finally, high Chrdl1 expression was associated with better clinical outcomes in patients with breast cancer. Together, our data reveal that Chrdl1 acts as a negative regulator of malignant breast cancer phenotypes through inhibition of BMP signaling.

Published
2016

19. Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

Author

Dumeaux, Vanessa, primary, Massahi, Samira, additional, Bettauer, Van, additional, Mottola, Austin, additional, Dukovny, Anna, additional, Khurdia, Sanny Singh, additional, Costa, Anna Carolina Borges Pereira, additional, Omran, Raha Parvizi, additional, Simpson, Shawn, additional, Xie, Jinglin Lucy, additional, Whiteway, Malcolm, additional, Berman, Judith, additional, and Hallett, Michael T, additional

Published
2023
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21. Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS.

Author

Zastepa, Evelyn, Fitz-Gerald, Leslie, Hallett, Michael, Antel, Jack, Bar-Or, Amit, Lapierre, Yves, Haegert, David, and Baranzini, Sergio

Subjects
Adult, CD4-Positive T-Lymphocytes, Disease Progression, Female, Gene Expression, Humans, Immunity, Innate, Lymphocyte Activation, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Receptors, Antigen, T-Cell
Abstract

OBJECTIVE: Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple sclerosis (SPMS). METHODS: We compared the naive CD4 T-cell gene expression profiles of 19 patients with SPMS and 14 healthy controls (HCs) using a whole-genome microarray approach. We analyzed surface protein expression of critical genes by flow cytometry after T-cell receptor (TCR) stimulation of naive CD4 T cells isolated from HCs and patients with SPMS. RESULTS: Hierarchical clustering segregated patients with SPMS into 2 subgroups: SP-1, which had a short duration of relapsing-remitting multiple sclerosis (MS), and SP-2, which had a long duration of relapsing-remitting MS. SP-1 patients upregulated numerous immune genes, including genes within TCR and toll-like receptor (TLR) signaling pathways. SP-2 patients showed immune gene downregulation in comparison with HCs. We identified an SP-1-specific transcriptional signature of 3 genes (TLR4, TLR2, and chemokine receptor 1), and these genes had higher surface protein expression in SP-1 than in SP-2. After TCR stimulation for 48 hours, only SP-1 showed a progressive linear increase in TLR2 and TLR4 protein expression. CONCLUSIONS: Differences in naive CD4 T-cell biology, notably of TCR and TLR signaling pathways, identified patients with MS with more rapid conversion to secondary progression, a critical determinant of long-term disability in MS.

Published
2014

23. Author response: Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

Author

Dumeaux, Vanessa, primary, Massahi, Samira, additional, Bettauer, Van, additional, Mottola, Austin, additional, Dukovny, Anna, additional, Khurdia, Sanny Singh, additional, Costa, Anna Carolina Borges Pereira, additional, Omran, Raha Parvizi, additional, Simpson, Shawn, additional, Xie, Jinglin Lucy, additional, Whiteway, Malcolm, additional, Berman, Judith, additional, and Hallett, Michael T, additional

Published
2023
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27. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Author

Gruosso, Tina, Gigoux, Mathieu, Manem, Venkata Satya Kumar, Bertos, Nicholas, Zuo, Dongmei, Perlitch, Irina, Saleh, Sadiq Mehdi Ismail, Zhao, Hong, Souleimanova, Margarita, Johnson, Radia Marie, Monette, Anne, Ramos, Valentina Munoz, Hallett, Michael Trevor, Stagg, John, Lapointe, Rejean, Omeroglu, Atilla, Meterissian, Sarkis, Buisseret, Laurence, Van den Eyden, Gert, Salgado, Roberto, Guiot, Marie-Christine, Haibe-Kains, Benjamin, and Park, Morag

Subjects
Breast cancer -- Risk factors -- Genetic aspects -- Care and treatment, Gene expression -- Research, Immune system -- Health aspects, Outcome and process assessment (Medical care) -- Analysis, Cancer treatment, T cells, Apoptosis, Tumors, Cell death, Genes, Biochemistry, Health care industry
Abstract

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial resolution of immune cells with laser capture microdissection gene expression profiles, we defined distinct TIME stratification in TNBC, with implications for current therapies including immune checkpoint blockade. TNBCs with an immunoreactive microenvironment exhibited tumoral infiltration of granzyme [B.sup.+][CD8.sup.+] T cells (Gzm[B.sup.+][CD8.sup.+] T cells), a type 1 IFN signature, and elevated expression of multiple immune inhibitory molecules including indoleamine 2,3-dioxygenase (IDO) and programmed cell death ligand 1 (PD-L1), and resulted in good outcomes. An 'immune-cold' microenvironment with an absence of tumoral [CD8.sup.+] T cells was defined by elevated expression of the immunosuppressive marker B7-H4, signatures of fibrotic stroma, and poor outcomes. A distinct poor-outcome immunomodulatory microenvironment, hitherto poorly characterized, exhibited stromal restriction of [CD8.sup.+] T cells, stromal expression of PD-L1, and enrichment for signatures of cholesterol biosynthesis. Metasignatures defining these TIME subtypes allowed us to stratify TNBCs, predict outcomes, and identify potential therapeutic targets for TNBC., Introduction Triple-negative breast cancer (TNBC) lacks targeted therapies, has high rates of distant recurrence, and poor overall survival for patients. Large-scale gene expression and sequencing studies have revealed high heterogeneity [...]

Published
2019
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28. Confronting Christian Penal Charity: Neoliberalism and the Rebirth of Religious Penitentiaries

Author

Hallett, Michael

Subjects
Theological seminaries -- Laws, regulations and rules -- Services -- Location, Religious charities -- Services -- Analysis, Prisoners -- Education -- Beliefs, opinions and attitudes -- Religious aspects, Neoliberalism -- Influence, Government regulation, International relations, Law
Abstract

This article addresses the rise of Christian seminary programs in US prisons as a function of penal regime change in late-modern corrections. The article documents the neoliberal roots of faith-based [...]

Published
2019

29. Editor's Introduction

Author

Hallett, Michael

Subjects
International relations, Law
Abstract

It is perhaps unfortunate, from a moral and pragmatic point of view, that the United States is not on the verge of revolution. But until a revolutionary situation exists in [...]

Published
2019

30. Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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31. Supplementary Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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34. Data from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Author

Boulay, Pierre-Luc, primary, Mitchell, Louise, primary, Turpin, Jason, primary, Huot-Marchand, Julie-Émilie, primary, Lavoie, Cynthia, primary, Sanguin-Gendreau, Virginie, primary, Jones, Laura, primary, Mitra, Shreya, primary, Livingstone, Julie M., primary, Campbell, Shirley, primary, Hallett, Michael, primary, Mills, Gordon B., primary, Park, Morag, primary, Chodosh, Lewis, primary, Strathdee, Douglas, primary, Norman, Jim C., primary, and Muller, William J., primary

Published
2023
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35. Supplemental Figure 2 In vitro role of FIP1C in regulating cell proliferation in ErbB2/neuNDL primary cells from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Author

Boulay, Pierre-Luc, primary, Mitchell, Louise, primary, Turpin, Jason, primary, Huot-Marchand, Julie-Émilie, primary, Lavoie, Cynthia, primary, Sanguin-Gendreau, Virginie, primary, Jones, Laura, primary, Mitra, Shreya, primary, Livingstone, Julie M., primary, Campbell, Shirley, primary, Hallett, Michael, primary, Mills, Gordon B., primary, Park, Morag, primary, Chodosh, Lewis, primary, Strathdee, Douglas, primary, Norman, Jim C., primary, and Muller, William J., primary

Published
2023
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36. Supplemental Figure 3 Characterization of FIP1C/ErbB2/neuNDL cell lines in regulating tumor growth using athymic NCr mice from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Author

Boulay, Pierre-Luc, primary, Mitchell, Louise, primary, Turpin, Jason, primary, Huot-Marchand, Julie-Émilie, primary, Lavoie, Cynthia, primary, Sanguin-Gendreau, Virginie, primary, Jones, Laura, primary, Mitra, Shreya, primary, Livingstone, Julie M., primary, Campbell, Shirley, primary, Hallett, Michael, primary, Mills, Gordon B., primary, Park, Morag, primary, Chodosh, Lewis, primary, Strathdee, Douglas, primary, Norman, Jim C., primary, and Muller, William J., primary

Published
2023
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37. Supplementary Table 2 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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38. Data from Glycoprotein Nonmetastatic B Is an Independent Prognostic Indicator of Recurrence and a Novel Therapeutic Target in Breast Cancer

Author

Rose, April A.N., primary, Grosset, Andrée-Anne, primary, Dong, Zhifeng, primary, Russo, Caterina, primary, MacDonald, Patricia A., primary, Bertos, Nicholas R., primary, St-Pierre, Yves, primary, Simantov, Ronit, primary, Hallett, Michael, primary, Park, Morag, primary, Gaboury, Louis, primary, and Siegel, Peter M., primary

Published
2023
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40. Supplementary Figure 4 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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41. Supplementary Figure 8 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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42. Supplemental Materials and Methods from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Author

Boulay, Pierre-Luc, primary, Mitchell, Louise, primary, Turpin, Jason, primary, Huot-Marchand, Julie-Émilie, primary, Lavoie, Cynthia, primary, Sanguin-Gendreau, Virginie, primary, Jones, Laura, primary, Mitra, Shreya, primary, Livingstone, Julie M., primary, Campbell, Shirley, primary, Hallett, Michael, primary, Mills, Gordon B., primary, Park, Morag, primary, Chodosh, Lewis, primary, Strathdee, Douglas, primary, Norman, Jim C., primary, and Muller, William J., primary

Published
2023
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43. Supplementary Data from Glycoprotein Nonmetastatic B Is an Independent Prognostic Indicator of Recurrence and a Novel Therapeutic Target in Breast Cancer

Author

Rose, April A.N., primary, Grosset, Andrée-Anne, primary, Dong, Zhifeng, primary, Russo, Caterina, primary, MacDonald, Patricia A., primary, Bertos, Nicholas R., primary, St-Pierre, Yves, primary, Simantov, Ronit, primary, Hallett, Michael, primary, Park, Morag, primary, Gaboury, Louis, primary, and Siegel, Peter M., primary

Published
2023
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44. Supplementary Figure 6 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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45. Supplementary Figure 5 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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46. Supplemental Figure Legends from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

Author

Boulay, Pierre-Luc, primary, Mitchell, Louise, primary, Turpin, Jason, primary, Huot-Marchand, Julie-Émilie, primary, Lavoie, Cynthia, primary, Sanguin-Gendreau, Virginie, primary, Jones, Laura, primary, Mitra, Shreya, primary, Livingstone, Julie M., primary, Campbell, Shirley, primary, Hallett, Michael, primary, Mills, Gordon B., primary, Park, Morag, primary, Chodosh, Lewis, primary, Strathdee, Douglas, primary, Norman, Jim C., primary, and Muller, William J., primary

Published
2023
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47. Supplementary Figure 7 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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48. Supplementary Materials and Methods, Figure Legends, Table Legends from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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49. Supplementary Figure 3 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets

Author

Stefanska, Barbara, primary, Cheishvili, David, primary, Suderman, Matthew, primary, Arakelian, Ani, primary, Huang, Jian, primary, Hallett, Michael, primary, Han, Ze-Guang, primary, Al-Mahtab, Mamun, primary, Akbar, Sheikh Mohammad Fazle, primary, Khan, Wasif Ali, primary, Raqib, Rubhana, primary, Tanvir, Imrana, primary, Khan, Haseeb Ahmed, primary, Rabbani, Shafaat A., primary, and Szyf, Moshe, primary

Published
2023
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