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3. Author Correction: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

Author

Tretter, Celina, de Andrade Krätzig, Niklas, Pecoraro, Matteo, Lange, Sebastian, Seifert, Philipp, von Frankenberg, Clara, Untch, Johannes, Zuleger, Gabriela, Wilhelm, Mathias, Zolg, Daniel P., Dreyer, Florian S., Bräunlein, Eva, Engleitner, Thomas, Uhrig, Sebastian, Boxberg, Melanie, Steiger, Katja, Slotta-Huspenina, Julia, Ochsenreither, Sebastian, von Bubnoff, Nikolas, Bauer, Sebastian, Boerries, Melanie, Jost, Philipp J., Schenck, Kristina, Dresing, Iska, Bassermann, Florian, Friess, Helmut, Reim, Daniel, Grützmann, Konrad, Pfütze, Katrin, Klink, Barbara, Schröck, Evelin, Haller, Bernhard, Kuster, Bernhard, Mann, Matthias, Weichert, Wilko, Fröhling, Stefan, Rad, Roland, Hiltensperger, Michael, and Krackhardt, Angela M.

Published
2024
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5. COVID-19 in Female and Male Athletes: Symptoms, Clinical Findings, Outcome, and Prolonged Exercise Intolerance—A Prospective, Observational, Multicenter Cohort Study (CoSmo-S)

Author

Widmann, Manuel, Gaidai, Roman, Schubert, Isabel, Grummt, Maximilian, Bensen, Lieselotte, Kerling, Arno, Quermann, Anne, Zacher, Jonas, Vollrath, Shirin, Bizjak, Daniel Alexander, Beckendorf, Claudia, Egger, Florian, Hasler, Erik, Mellwig, Klaus-Peter, Fütterer, Cornelia, Wimbauer, Fritz, Vogel, Azin, Schoenfeld, Julia, Wüstenfeld, Jan C., Kastner, Tom, Barsch, Friedrich, Friedmann-Bette, Birgit, Bloch, Wilhelm, Meyer, Tim, Mayer, Frank, Wolfarth, Bernd, Roecker, Kai, Reinsberger, Claus, Haller, Bernhard, and Niess, Andreas M.

Published
2024
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9. Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

Author

Kuchler, Timon, Günthner, Roman, Ribeiro, Andrea, Hausinger, Renate, Streese, Lukas, Wöhnl, Anna, Kesseler, Veronika, Negele, Johanna, Assali, Tarek, Carbajo-Lozoya, Javier, Lech, Maciej, Schneider, Heike, Adorjan, Kristina, Stubbe, Hans Christian, Hanssen, Henner, Kotilar, Konstantin, Haller, Bernhard, Heemann, Uwe, and Schmaderer, Christoph

Published
2023
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11. Sequential Permutation Testing of Random Forest Variable Importance Measures

Author

Hapfelmeier, Alexander, Hornung, Roman, and Haller, Bernhard

Subjects
Statistics - Methodology, Computer Science - Machine Learning, Statistics - Applications, Statistics - Computation, Statistics - Machine Learning
Abstract

Hypothesis testing of random forest (RF) variable importance measures (VIMP) remains the subject of ongoing research. Among recent developments, heuristic approaches to parametric testing have been proposed whose distributional assumptions are based on empirical evidence. Other formal tests under regularity conditions were derived analytically. However, these approaches can be computationally expensive or even practically infeasible. This problem also occurs with non-parametric permutation tests, which are, however, distribution-free and can generically be applied to any type of RF and VIMP. Embracing this advantage, it is proposed here to use sequential permutation tests and sequential p-value estimation to reduce the high computational costs associated with conventional permutation tests. The popular and widely used permutation VIMP serves as a practical and relevant application example. The results of simulation studies confirm that the theoretical properties of the sequential tests apply, that is, the type-I error probability is controlled at a nominal level and a high power is maintained with considerably fewer permutations needed in comparison to conventional permutation testing. The numerical stability of the methods is investigated in two additional application studies. In summary, theoretically sound sequential permutation testing of VIMP is possible at greatly reduced computational costs. Recommendations for application are given. A respective implementation is provided through the accompanying R package $rfvimptest$. The approach can also be easily applied to any kind of prediction model.

Published
2022
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13. Student Mistakes and Teacher Reactions in Bedside Teaching

Author

Rubisch, Hannah P. K., Blaschke, Anna-Lena, Berberat, Pascal O., Fuetterer, Cornelia S., Haller, Bernhard, and Gartmeier, Martin

Abstract

We analyse interactions between teachers and students during video-recorded bedside teaching sessions in internal medicine, orthopaedics and neurology. Multiple raters used a high-inference categorical scheme on 36 sessions. Our research questions concern the types of student mistakes, clinical teachers' reactions to them and if they use different strategies to address different types of mistakes. We used a Poisson model and generalized mixed models to analyse these research questions. Most frequently, students made reproduction mistakes. Relatively high rates of rejection and a similar prevalence of low and high levels of elaboration and correction time for students were observed. Reproduction mistakes were associated with the highest level of rejection and the lowest level of elaboration. High levels of elaboration were observed when students were applying skills in new situations. Students were most often allowed time to correct when mistakes in the areas of analysis or application of skills and knowledge had occurred. There is a decrease in the rate of making mistakes for neurology and orthopaedics compared to internal medicine. Reproduction mistakes influence significantly the outcome feedback compared to application mistakes. Analytic and reproduction mistakes influence elaboration significantly compared to application mistakes. We found a significant effect whether the lecturer allows time for correction of reproduction mistakes compared to application mistakes. These results contribute to the understanding of interactive, patient-centred clinical teaching as well as student mistakes and how teachers are reacting to them. Our descriptive findings provide an empirical basis for clinical teachers to react to student mistakes in didactically fruitful ways.

Published
2023
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16. Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

Author

Tretter, Celina, de Andrade Krätzig, Niklas, Pecoraro, Matteo, Lange, Sebastian, Seifert, Philipp, von Frankenberg, Clara, Untch, Johannes, Zuleger, Gabriela, Wilhelm, Mathias, Zolg, Daniel P., Dreyer, Florian S., Bräunlein, Eva, Engleitner, Thomas, Uhrig, Sebastian, Boxberg, Melanie, Steiger, Katja, Slotta-Huspenina, Julia, Ochsenreither, Sebastian, von Bubnoff, Nikolas, Bauer, Sebastian, Boerries, Melanie, Jost, Philipp J., Schenck, Kristina, Dresing, Iska, Bassermann, Florian, Friess, Helmut, Reim, Daniel, Grützmann, Konrad, Pfütze, Katrin, Klink, Barbara, Schröck, Evelin, Haller, Bernhard, Kuster, Bernhard, Mann, Matthias, Weichert, Wilko, Fröhling, Stefan, Rad, Roland, Hiltensperger, Michael, and Krackhardt, Angela M.

Published
2023
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19. High RIPK3 expression is associated with a higher risk of early kidney transplant failure

Author

Wahida, Adam, Schmaderer, Christoph, Büttner-Herold, Maike, Branca, Caterina, Donakonda, Sainitin, Haberfellner, Flora, Torrez, Carlos, Schmitz, Jessica, Schulze, Tobias, Seibt, Tobias, Öllinger, Rupert, Engleitner, Thomas, Haller, Bernhard, Steiger, Katja, Günthner, Roman, Lorenz, Georg, Yabal, Monica, Bachmann, Quirin, Braunisch, Matthias C., Moog, Philipp, Matevossian, Edouard, Aßfalg, Volker, Thorban, Stefan, Renders, Lutz, Späth, Martin R., Müller, Roman-Ulrich, Stippel, Dirk L., Weichert, Wilko, Slotta-Huspenina, Julia, von Vietinghoff, Sibylle, Viklicky, Ondrej, Green, Douglas R., Rad, Roland, Amann, Kerstin, Linkermann, Andreas, Bräsen, Jan Hinrich, Heemann, Uwe, and Kemmner, Stephan

Published
2023
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21. Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

Author

Kuchler, Timon, Günthner, Roman, Ribeiro, Andrea, Hausinger, Renate, Streese, Lukas, Wöhnl, Anna, Kesseler, Veronika, Negele, Johanna, Assali, Tarek, Carbajo-Lozoya, Javier, Lech, Maciej, Schneider, Heike, Adorjan, Kristina, Stubbe, Hans Christian, Hanssen, Henner, Kotilar, Konstantin, Haller, Bernhard, Heemann, Uwe, and Schmaderer, Christoph

Published
2023
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22. Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding

Author

Zhang, Pingfeng, Azizi, Latifeh, Kukkurainen, Sampo, Gao, Tong, Baikoghli, Mo, Jacquier, Marie-Claude, Sun, Yijuan, Määttä, Juha AE, Cheng, R Holland, Wehrle-Haller, Bernhard, Hytönen, Vesa P, and Wu, Jinhua

Subjects
Biochemistry and Cell Biology, Biological Sciences, Amino Acid Motifs, Animals, Binding Sites, Humans, Integrin beta3, Leucine, Mice, Microscopy, Electron, Transmission, Models, Molecular, Mutagenesis, Polylysine, Protein Domains, Protein Folding, Talin, talin, integrin, FERM domain, cell adhesion, NPxY motif
Abstract

Binding of the intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clustering. These processes are essential for cell adhesion, migration, and organ development. Although the talin head, the integrin-binding segment in talin, possesses a typical FERM-domain sequence, a truncated form has been crystallized in an unexpected, elongated form. This form, however, lacks a C-terminal fragment and possesses reduced β3-integrin binding. Here, we present a crystal structure of a full-length talin head in complex with the β3-integrin tail. The structure reveals a compact FERM-like conformation and a tightly associated N-P-L-Y motif of β3-integrin. A critical C-terminal poly-lysine motif mediates FERM interdomain contacts and assures the tight association with the β3-integrin cytoplasmic segment. Removal of the poly-lysine motif or disrupting the FERM-folded configuration of the talin head significantly impairs integrin activation and clustering. Therefore, structural characterization of the FERM-folded active talin head provides fundamental understanding of the regulatory mechanism of integrin function.

Published
2020

25. Can the Injected Dose Be Reduced in 68Ga-PSMA-11 PET/CT While Maintaining High Image Quality for Lesion Detection?

Author

Rauscher, Isabel, Fendler, Wolfgang P, Hope, Thomas A, Quon, Andrew, Nekolla, Stephan G, Calais, Jeremie, Richter, Antonia, Haller, Bernhard, Herrmann, Ken, Weber, Wolfgang A, Czernin, Johannes, and Eiber, Matthias

Subjects
Humans, Gallium Isotopes, Gallium Radioisotopes, Edetic Acid, Oligopeptides, Injections, Radiation Dosage, Quality Control, Aged, Aged, 80 and over, Middle Aged, Male, Positron Emission Tomography Computed Tomography, PSMA, dose reduction, image dose, prostate cancer, Cancer, Urologic Diseases, Prostate Cancer, Biomedical Imaging, Clinical Research, Clinical Sciences, Nuclear Medicine & Medical Imaging
Abstract

Our purpose was to define a clinically useful lower limit of injected dose for 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT imaging of prostate cancer. Methods: 68Ga-PSMA-11 PET/CT was performed on 11 patients. PET was acquired in list mode and reconstructed using a 3-min full acquisition, a 2-min acquisition, and a 1-min acquisition to generate images obtained with three thirds (standard dose), two thirds (low dose), and one third (very low dose) of the injected dose, respectively. Overall image quality (5-point scale) was assessed, and the detectability of PSMA-positive lesions was determined by 3 readers and compared with the reference standard. Results: Image quality declined with decreasing dose (mean score of 4.1 ± 0.4 for the standard dose, 3.4 ± 0.7 for the low dose, and 1.9 ± 0.4 for the very low dose; all P < 0.05). Readers 1, 2, and 3 correctly identified the lesions (n = 21) at a rate of 100%, 100%, and 95% with the standard dose; 95%, 81%, and 90% with the low dose; and 71%, 76%, and 59% with the very low dose, respectively. Conclusion: 68Ga-PSMA-11 dose reduction is not feasible without a negative impact on image quality and lesion detectability.

Published
2020

26. Associations of Perioperative Variables With the 30-Day Risk of Stroke or Death in Carotid Endarterectomy for Symptomatic Carotid Stenosis.

Author

Knappich, Christoph, Kuehnl, Andreas, Haller, Bernhard, Salvermoser, Michael, Algra, Ale, Becquemin, Jean-Pierre, Bonati, Leo H, Bulbulia, Richard, Calvet, David, Fraedrich, Gustav, Gregson, John, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Jansen, Olav, Malas, Mahmoud B, Ringleb, Peter A, Brown, Martin M, Mas, Jean-Louis, Brott, Thomas G, Morris, Dylan R, Lewis, Steff C, and Eckstein, Hans-Henning

Subjects
Humans, Carotid Stenosis, Postoperative Complications, Anesthesia, Local, Anesthesia, General, Endarterectomy, Carotid, Risk Factors, Aged, Middle Aged, Female, Male, Stroke, anesthesia, death, endarterectomy, carotid, humans, stroke, Clinical Research, Neurosciences, Brain Disorders, endarterectomy, carotid, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and Purpose- This analysis was performed to assess the association between perioperative and clinical variables and the 30-day risk of stroke or death after carotid endarterectomy for symptomatic carotid stenosis. Methods- Individual patient-level data from the 5 largest randomized controlled carotid trials were pooled in the Carotid Stenosis Trialists' Collaboration database. A total of 4181 patients who received carotid endarterectomy for symptomatic stenosis per protocol were included. Determinants of outcome included carotid endarterectomy technique, type of anesthesia, intraoperative neurophysiological monitoring, shunting, antiplatelet medication, and clinical variables. Stroke or death within 30 days after carotid endarterectomy was the primary outcome. Adjusted risk ratios (aRRs) were estimated in multilevel multivariable analyses using a Poisson regression model. Results- Mean age was 69.5±9.2 years (70.7% men). The 30-day stroke or death rate was 4.3%. In the multivariable regression analysis, local anesthesia was associated with a lower primary outcome rate (versus general anesthesia; aRR, 0.70 [95% CI, 0.50-0.99]). Shunting (aRR, 1.43 [95% CI, 1.05-1.95]), a contralateral high-grade carotid stenosis or occlusion (aRR, 1.58 [95% CI, 1.02-2.47]), and a more severe neurological deficit (mRS, 3-5 versus 0-2: aRR, 2.51 [95% CI, 1.30-4.83]) were associated with higher primary outcome rates. None of the other characteristics were significantly associated with the perioperative stroke or death risk. Conclusions- The current results indicate lower perioperative stroke or death rates in patients operated upon under local anesthesia, whereas a more severe neurological deficit and a contralateral high-grade carotid stenosis or occlusion were identified as potential risk factors. Despite a possible selection bias and patients not having been randomized, these findings might be useful to guide surgeons and anesthetists when treating patients with symptomatic carotid disease.

Published
2019

28. Infection Control Measures and Prevalence of SARS-CoV-2 IgG among 4,554 University Hospital Employees, Munich, Germany

Author

Erber, Johanna, Kappler, Verena, Haller, Bernhard, Mijocevic, Hrvoje, Galhoz, Ana, da Costa, Clarissa Prazeres, Gebhardt, Friedemann, Graf, Natalia, Hoffmann, Dieter, Thaler, Markus, Lorenz, Elke, Roggendorf, Hedwig, Kohlmayer, Florian, Henkel, Andreas, Menden, Michael P., Ruland, Jurgen, Spinner, Christoph D., Protzer, Ulrike, Knolle, Percy, and Lingor, Paul

Subjects
Infection control -- Methods, Hospitals, University -- Safety and security measures, Medical personnel -- Health aspects, Health
Abstract

Healthcare workers (HCWs) are exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the private context, as well as professionally with varying exposure risk depending on their workplace. Prevalence [...]

Published
2022
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29. Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism

Author

Jakwerth, Constanze A., Feuerherd, Martin, Guerth, Ferdinand M., Oelsner, Madlen, Schellhammer, Linda, Giglberger, Johanna, Pechtold, Lisa, Jerin, Claudia, Kugler, Luisa, Mogler, Carolin, Haller, Bernhard, Erb, Anna, Wollenberg, Barbara, Spinner, Christoph D., Buch, Thorsten, Protzer, Ulrike, Schmidt-Weber, Carsten B., Zissler, Ulrich M., and Chaker, Adam M.

Published
2022
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32. A randomized prospective cross over study on the effects of medium cut-off membranes on T cellular and serologic immune phenotypes in hemodialysis

Author

Lorenz, Georg, Shen, Yuli, Hausinger, Renate Ilona, Scheid, Caroline, Eckermann, Marie, Hornung, Sophia, Cardoso, Joana, Lech, Maciej, Ribeiro, Andrea, Haller, Bernhard, Holzmann-Littig, Christopher, Steubl, Dominik, Braunisch, Matthias C., Günthner, Roman, Poschenrieder, Andreas, Freitag, Britt, Weber, Mario, Luppa, Peter, Heemann, Uwe, and Schmaderer, Christoph

Published
2022
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33. Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report

Author

Drude, Natascha Ingrid, Martinez-Gamboa, Lorena, Danziger, Meggie, Collazo, Anja, Kniffert, Silke, Wiebach, Janine, Nilsonne, Gustav, Konietschke, Frank, Piper, Sophie K., Pawel, Samuel, Micheloud, Charlotte, Held, Leonhard, Frommlet, Florian, Segelcke, Daniel, Pogatzki-Zahn, Esther M., Voelkl, Bernhard, Friede, Tim, Brunner, Edgar, Dempfle, Astrid, Haller, Bernhard, Jung, Marie Juliane, Riecken, Lars Björn, Kuhn, Hans-Georg, Tenbusch, Matthias, Higuita, Lina Maria Serna, Remarque, Edmond J., Grüninger-Egli, Servan Luciano, Manske, Katrin, Kobold, Sebastian, Rivalan, Marion, Wedekind, Lisa, Wilcke, Juliane C., Boulesteix, Anne-Laure, Meinhardt, Marcus W., Spanagel, Rainer, Hettmer, Simone, von Lüttichau, Irene, Regina, Carla, Dirnagl, Ulrich, and Toelch, Ulf

Published
2022
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34. Dark-field chest x-ray imaging: first experience in patients with alpha1-antitrypsin deficiency

Author

Zimmermann, Gregor S., Fingerle, Alexander A., Renger, Bernhard, Laugwitz, Karl-Ludwig, Hautmann, Hubert, Sauter, Andreas, Meurer, Felix, Gassert, Florian Tilman, Bodden, Jannis, Müller-Leisse, Christina, Renz, Martin, Rummeny, Ernst J., Makowski, Marcus R., Willer, Konstantin, Noichl, Wolfgang, De Marco, Fabio, Frank, Manuela, Urban, Theresa, Schick, Rafael C., Herzen, Julia, Koehler, Thomas, Haller, Bernhard, Pfeiffer, Daniela, and Pfeiffer, Franz

Published
2022
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36. Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia

Author

Frank, Manuela, Gassert, Florian T., Urban, Theresa, Willer, Konstantin, Noichl, Wolfgang, Schick, Rafael, Schultheiss, Manuel, Viermetz, Manuel, Gleich, Bernhard, De Marco, Fabio, Herzen, Julia, Koehler, Thomas, Engel, Klaus Jürgen, Renger, Bernhard, Gassert, Felix G., Sauter, Andreas, Fingerle, Alexander A., Haller, Bernhard, Makowski, Marcus R., Pfeiffer, Daniela, and Pfeiffer, Franz

Published
2022
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37. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Author

Koerber, Nina, Priller, Alina, Yazici, Sarah, Bauer, Tanja, Cheng, Cho-Chin, Mijočević, Hrvoje, Wintersteller, Hannah, Jeske, Samuel, Vogel, Emanuel, Feuerherd, Martin, Tinnefeld, Kathrin, Winter, Christof, Ruland, Jürgen, Gerhard, Markus, Haller, Bernhard, Christa, Catharina, Zelger, Otto, Roggendorf, Hedwig, Halle, Martin, Erber, Johanna, Lingor, Paul, Keppler, Oliver, Zehn, Dietmar, Protzer, Ulrike, and Knolle, Percy A.

Published
2022
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39. Novel Detection of Pleomorphic Adenomas via Analysis of 68 Ga-DOTATOC PET/CT Imaging.

Author

Johnson, Felix, Kloppenburg, Marcel, Hofauer, Benedikt, Wollenberg, Barbara, Hoch, Cosima C., Stögbauer, Fabian, Haller, Bernhard, Knopf, Andreas, Strassen, Ulrich, and Notohamiprodjo, Susan

Subjects
LIVER physiology, RECURRENT laryngeal nerve, GRANULOMA, COMPUTED tomography, EARLY detection of cancer, SALIVARY gland tumors, POSITRON emission tomography, RETROSPECTIVE studies, MAGNETIC resonance imaging, RADIOISOTOPES, DESCRIPTIVE statistics, IMMUNOHISTOCHEMISTRY, OPERATIVE surgery, ADENOMA, CANCER cells, COMPARATIVE studies, CELL receptors
Abstract

Simple Summary: We present in this study novel data which demonstrates that the most common type of tumor of the salivary glands may be accurately diagnosed using a specific type of radiological imaging. This may be used to help discriminate this tumor or recurrent versions of it amid various types of benign and malignant tumors. Furthermore, this data suggest that new avenues of minimally invasive therapy may be viable for these tumors and potentially even malignant versions of these tumors and should be examined in further studies. Introduction: Currently, the diagnosis of salivary gland tumors using imaging techniques is unreliable. Methods: In this monocentric retrospective study, we examined patients who received a 68Ga-DOTATOC PET/CT and subsequently underwent a salivary gland tumor resection between 1 January 2010 and 31 December 2021. PET/CT image assessment was compared with somatostatin receptor (SSTR) expression and histology. Results: Thirteen patients (five pleomorphic adenoma (PA) and eight other parotid lesions (OPL)) received a 68Ga-DOTATOC PET/CT. Imaging displayed strong focal tracer uptake in all PA except for one with strong tumor to background discrimination. PA revealed higher SUVmax, SUVmean, liver and blood pool quotients than those of Warthin tumors (WT) and of OPL. In comparison to the contralateral parotid, SUVmax (p = 0.02), SUVmean (p = 0.02), liver quotient (p = 0.03) and blood pool quotient (p = 0.03) were all significantly higher. In contrast, WT and OPL showed in relation to the contralateral parotid no significant differences of SUVmax (WT p = 0.79; OPL p = 0.11), SUVmean (WT p = 1.0; OPL p = 0.08), liver quotient (WT p = 0.5; OPL p = 0.08) and blood pool quotient (WT p = 0.8; OPL p = 0.19). Two PA and one granuloma were not available for examination. In the immunohistochemal analysis, all PA demonstrated the highest intensity of SSTR2 expression (grade 3). Furthermore, PA had a high percentage of cells expressing SSTR2 (20%, 80% and 55%). Conclusions: A strong tracer uptake in PA was shown in 68Ga-DOTATOC PET/CT. This may allow physicians to utilize radioligated somatostatin analogue PET CT/MR imaging to accurately diagnose PA. Additionally, it may be possible in the future to treat the PA with a noninvasive peptide receptor radionuclide therapy or with somatostatin analogues. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Tixagevimab/Cilgavimab for COVID-19 Pre-Exposure Prophylaxis in Hematologic Patients—A Tailored Approach Based on SARS-CoV-2 Vaccine Response.

Author

Braitsch, Krischan, Jeske, Samuel D., Stroh, Jacob, Hefter, Maike, Platen, Louise, Bachmann, Quirin, Renders, Lutz, Protzer, Ulrike, Götze, Katharina S., Herhaus, Peter, Verbeek, Mareike, Spinner, Christoph D., Bassermann, Florian, Högner, Marion, Haller, Bernhard, Schneider, Jochen, and Heider, Michael

Subjects
SARS-CoV-2, COVID-19, COVID-19 pandemic, HEMATOPOIETIC stem cell transplantation, SARS-CoV-2 Omicron variant
Abstract

Patients with hematologic malignancies still face a significant risk of severe coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-neutralizing monoclonal antibody combination tixagevimab/cilgavimab (TIX/CGB) could be administered to immunocompromised patients for pre-exposure prophylaxis (PrEP) before the emergence of TIX/CGB-resistant COVID-19 Omicron variants. TIX/CGB application could be carried out regardless of the host's immune response to previous active SARS-CoV-2 vaccinations or infections. Because the efficacy of COVID-19 PrEP remains unclear, especially in SARS-CoV-2-seropositive patients, German national guidelines recommended TIX/CGB PrEP only for SARS-CoV-2-seronegative patients in addition to an intensified active vaccination schedule. Having followed these guidelines, we now report the characteristics and outcomes of 54 recipients of TIX/CGB PrEP in SARS-CoV-2-seronegative patients with hematological disease from a German tertiary medical center and compare them to 125 seropositive patients who did not receive any PrEP. While the number of patients with B-cell lymphomas was significantly higher in the seronegative cohort (33 (61%) vs. 18 (14%) cases, p < 0.01), patients with myeloid diseases were significantly more frequent in the seropositive cohort (51 (41%) vs. 5 (9%) cases, p < 0.01). Strikingly, patients who had undergone allogeneic hematopoietic stem cell transplantation were significantly more likely (forty-nine (39%) vs. six (11%) cases, p < 0.01) to be SARS-CoV-2 seropositive. We observed that prophylactic application of TIX/CGB PrEP to a highly vulnerable group of SARS-CoV-2-seronegative patients resulted in a similar number of COVID-19 breakthrough infections compared to the untreated seropositive control group (16 (32%) vs. 39 (36%), p = 0.62) and comparable COVID-19-related outcomes like hospitalization and oxygen requirement throughout an extended follow-up period of 12 months. In conclusion, our results support the tailored approach of administering TIX/CGB PrEP only to SARS-CoV-2-seronegative patients during the COVID-19 pandemic and might provide a rationale for similar strategies during future outbreaks/diseases, especially in times of initial limited availability and/or financial constraints. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Electrocardiographic parameters of left ventricular hypertrophy and prediction of mortality in hemodialysis patients

Author

Braunisch, Matthias C., Gundel, Peter, Werfel, Stanislas, Mayer, Christopher C., Bauer, Axel, Haller, Bernhard, Günthner, Roman, Lorenz, Georg, Angermann, Susanne, Matschkal, Julia, Schaller, Carolin, Holzmann-Littig, Christopher, Kemmner, Stephan, Mann, Johannes, Krieter, Axel, Renders, Lutz, Wassertheurer, Siegfried, Schmidt, Georg, Heemann, Uwe, Malik, Marek, and Schmaderer, Christoph

Published
2022
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46. SARS-CoV-2 Neutralization Capacity in Hemodialysis Patients with and without a Fifth Vaccination with the Updated Comirnaty Original/Omicron BA.4-5 Vaccine

Author

Liao, Bo-Hung, primary, Platen, Louise, additional, Grommes, Myriam, additional, Cheng, Cho-Chin, additional, Holzmann-Littig, Christopher, additional, Christa, Catharina, additional, Haller, Bernhard, additional, Kappler, Verena, additional, Bester, Romina, additional, Werz, Maia Lucia, additional, Platen, Eva, additional, Eggerer, Peter, additional, Tréguer, Laëtitia, additional, Küchle, Claudius, additional, Schmaderer, Christoph, additional, Heemann, Uwe, additional, Renders, Lutz, additional, Protzer, Ulrike, additional, and Braunisch, Matthias Christoph, additional

Published
2024
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47. Immunothrombosis of acute care patients quantified with phase imaging flow cytometry

Author

Hayden, Oliver, primary, Diepold, Klaus, additional, Klenk, Christian, additional, Erber, Johanna, additional, Fresacher, David, additional, Röhrl, Stefan, additional, Lengl, Manuel, additional, Heim, Dominik, additional, Irl, Hedwig, additional, Schlegel, Martin, additional, Haller, Bernhard, additional, Lahmer, Tobias, additional, Rasch, Sebastian, additional, Krell, Johannes, additional, Delikoyun, Kerem, additional, Chen, Qianyu, additional, Kuan, Win Sen, additional, Cove, Matt, additional, Schneider, Gerhard, additional, Song, John, additional, Lip, Chew Ka, additional, and Javarappa, Komal, additional

Published
2024
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50. The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations

Author

Willvonseder, Barbara, Stögbauer, Fabian, Steiger, Katja, Jesinghaus, Moritz, Kuhn, Peer-Hendrik, Brambs, Christine, Engel, Jutta, Bronger, Holger, Schmidt, Georg Philipp, Haller, Bernhard, Weichert, Wilko, Keller, Gisela, Noske, Aurelia, Pfarr, Nicole, and Boxberg, Melanie

Published
2021
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