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385 results on '"Hall CM"'

2. VDAC2 enables BAX to mediate apoptosis and limit tumor development

Author

Chin, HS, Li, MX, Tan, IKL, Ninnis, RL, Reljic, B, Scicluna, K, Dagley, LF, Sandow, JJ, Kelly, GL, Samson, AL, Chappaz, S, Khaw, SL, Chang, C, Morokoff, A, Brinkmann, K, Webb, A, Hockings, C, Hall, CM, Kueh, AJ, Ryan, MT, Kluck, RM, Bouillet, P, Herold, MJ, Gray, DHD, Huang, DCS, van Delft, MF, Dewson, G, Chin, HS, Li, MX, Tan, IKL, Ninnis, RL, Reljic, B, Scicluna, K, Dagley, LF, Sandow, JJ, Kelly, GL, Samson, AL, Chappaz, S, Khaw, SL, Chang, C, Morokoff, A, Brinkmann, K, Webb, A, Hockings, C, Hall, CM, Kueh, AJ, Ryan, MT, Kluck, RM, Bouillet, P, Herold, MJ, Gray, DHD, Huang, DCS, van Delft, MF, and Dewson, G

Abstract

Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CRISPR/Cas9 screen, we identified VDAC2 (voltage-dependent anion channel 2) as important for BAX, but not BAK, to function. Genetic deletion of VDAC2 abrogated the association of BAX and BAK with mitochondrial complexes containing VDAC1, VDAC2, and VDAC3, but only inhibited BAX apoptotic function. Deleting VDAC2 phenocopied the loss of BAX in impairing both the killing of tumor cells by anti-cancer agents and the ability to suppress tumor formation. Together, our studies show that efficient BAX-mediated apoptosis depends on VDAC2, and reveal a striking difference in how BAX and BAK are functionally impacted by their interactions with VDAC2.

Published
2018

5. Optimizing or maximizing growth? A challenge for sustainable tourism

Author

Gössling, S, Ring, A, Dwyer, L, Andersson, AC, Hall, CM, Gössling, S, Ring, A, Dwyer, L, Andersson, AC, and Hall, CM

Abstract

Virtually all destinations seek to increase tourist numbers, pursuing economic maximization strategies. Considerably less attention is paid to optimizing existing tourist systems to create more profitable, stable, resilient and potentially more sustainable entities. While aspects of tourist expenditure, average length of stay and seasonality as three key destination management variables have received considerable attention in the literature, focus has usually been on the identification of “profitable” tourism markets by considering observed patterns of spending, length of stay and vacation timing. Building on such earlier studies, this paper focuses on flexibilities in these parameters: could tourists have spent more, stayed longer or visited during a different season? Perceptions of destination expensiveness as a potential deterrent to visitation were also addressed. Based on a sample (n = 1914) of domestic and international tourists in the Swedish cities of Kalmar and Stockholm, data were collected in face-to-face interviews using questionnaires. Results indicate considerable potential to optimize the Swedish tourism system with regard to all variables studied, while also providing new insights for destination management in the context of economic resilience. Results also indicate the need for researchers everywhere to have detailed market knowledge if they are to persuade the industry to change its sustainability behavior.

Published
2016

6. On climate change skepticism and denial in tourism

Author

Hall, CM, Amelung, B, Cohen, S, Eijgelaar, E, Gossling, S, Higham, J, ...., Scott, D, Hall, CM, Amelung, B, Cohen, S, Eijgelaar, E, Gossling, S, Higham, J, ...., and Scott, D

Abstract

The period leading to and immediately after the release of the IPCC’s fifth series of climate change assessments saw substantial efforts by climate change denial interests to portray anthropogenic climate change (ACC) as either unproven theory or a negligible contribution to natural climate variability, including the relationship between tourism and climate change. This paper responds to those claims by stressing that the extent of scientific consensus suggests that human-induced warming of the climate system is unequivocal. Secondly, it responds in the context of tourism research and ACC, highlighting tourism’s significant contribution to greenhouse gas emissions, as well as climate change’s potential impacts on tourism at different scales. The paper exposes the tactics used in ACC denial papers to question climate change science by referring to non-peer reviewed literature, outlier studies and misinterpretation of research, as well as potential links to think-tanks and interest groups. The paper concludes that climate change science does need to improve its communication strategies but that the world-view of some individuals and interests likely precludes acceptance. The connection between ACC and sustainability illustrates the need for debate on adaptation and mitigation strategies, but that debate needs to be grounded in scientific principles not unsupported skepticism.

Published
2015

7. A new lethal neonatal short limb dwarfism

Author

Hall Cm, Devadas K, and al Gazali Li

Subjects
musculoskeletal diseases, Genetics, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system diseases, genetic structures, business.industry, General Medicine, eye diseases, Pathology and Forensic Medicine, Inheritance (object-oriented programming), Short-limb dwarfism, Pediatrics, Perinatology and Child Health, Medicine, Anatomy, business, Genetics (clinical)
Abstract

We report on a baby with an apparently new type of lethal short limb dwarfism. The inheritance appears to be autosomal recessive.

Published
1996

8. Lethal acrofacial dysostosis, pre- and post-axial defects of the hands, and bilateral renal agenesis

Author

Rosser Em, Alan W. Bates, Irene Scheimberg, Hall Cm, and Morgan H

Subjects
Bicornuate uterus, Craniofacial abnormality, Kidney, Pathology and Forensic Medicine, Craniofacial Abnormalities, Fetus, Pregnancy, Medicine, Humans, Abnormalities, Multiple, Renal agenesis, Genetics (clinical), business.industry, Single umbilical artery, Infant, Newborn, Dysostosis, General Medicine, Anatomy, medicine.disease, Bilateral Renal Agenesis, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Female, business, Hand Deformities, Congenital
Abstract

We report a female fetus with a previously undescribed form of mandibulofacial dysostosis with mesomelic limb abnormalities, pre- and post-axial defects of the hands, bilateral renal agenesis, bicornuate uterus, and a single umbilical artery.

Published
2002

9. Pseudoachondroplasia and Multiple Epiphyseal Dysplasia: A 7-Year Comprehensive Analysis of the Known Disease Genes Identify Novel and Recurrent Mutations and Provides an Accurate Assessment of Their Relative Contribution

Author

Jackson, GC, Mittaz-Crettol, L, Taylor, JA, Mortier, GR, Spranger, J, Zabel, B, Le Merrer, M, Cormier-Daire, V, Hall, CM, Offiah, A, Wright, MJ, Savarirayan, R, Nishimura, G, Ramsden, SC, Elles, R, Bonafe, L, Superti-Furga, A, Unger, S, Zankl, A, Briggs, MD, Jackson, GC, Mittaz-Crettol, L, Taylor, JA, Mortier, GR, Spranger, J, Zabel, B, Le Merrer, M, Cormier-Daire, V, Hall, CM, Offiah, A, Wright, MJ, Savarirayan, R, Nishimura, G, Ramsden, SC, Elles, R, Bonafe, L, Superti-Furga, A, Unger, S, Zankl, A, and Briggs, MD

Abstract

Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are relatively common skeletal dysplasias resulting in short-limbed dwarfism, joint pain, and stiffness. PSACH and the largest proportion of autosomal dominant MED (AD-MED) results from mutations in cartilage oligomeric matrix protein (COMP); however, AD-MED is genetically heterogenous and can also result from mutations in matrilin-3 (MATN3) and type IX collagen (COL9A1, COL9A2, and COL9A3). In contrast, autosomal recessive MED (rMED) appears to result exclusively from mutations in sulphate transporter solute carrier family 26 (SLC26A2). The diagnosis of PSACH and MED can be difficult for the nonexpert due to various complications and similarities with other related diseases and often mutation analysis is requested to either confirm or exclude the diagnosis. Since 2003, the European Skeletal Dysplasia Network (ESDN) has used an on-line review system to efficiently diagnose cases referred to the network prior to mutation analysis. In this study, we present the molecular findings in 130 patients referred to ESDN, which includes the identification of novel and recurrent mutations in over 100 patients. Furthermore, this study provides the first indication of the relative contribution of each gene and confirms that they account for the majority of PSACH and MED.

Published
2012

10. Spondyloepiphyseal dysplasia with nephrotic syndrome (Schimke immunoosseous dysplasia)

Author

Rottenberg Gt, Shaw Dg, and Hall Cm

Subjects
Spondyloepiphyseal dysplasia, medicine.medical_specialty, Immunity, Cellular, Nephrotic Syndrome, business.industry, Immunologic Deficiency Syndromes, medicine.disease, Osteochondrodysplasias, Dermatology, Radiography, Child, Preschool, Pediatrics, Perinatology and Child Health, medicine, Humans, Orthopedics and Sports Medicine, Female, business, Nephrotic syndrome, SCHIMKE IMMUNOOSSEOUS DYSPLASIA, Growth Disorders, Defective cellular immunity
Abstract

We report a 3-year-old girl with the association of spondyloepiphyseal dysplasia, nephrotic syndrome, and signs of defective cellular immunity. The findings are similar to those reported by Spranger et al., which have become known as Schimke immunoosseous dysplasia.

Published
1997

12. IGF-I and IGF-binding protein-3 measurements on filter paper blood spots in children and adolescents on GH treatment: use in monitoring and as markers of growth performance

Author

Das, U, primary, Whatmore, AJ, additional, Khosravi, J, additional, Wales, JK, additional, Butler, G, additional, Kibirige, MS, additional, Diamandi, A, additional, Jones, J, additional, Patel, L, additional, Hall, CM, additional, Price, DA, additional, and Clayton, PE, additional

Published
2003
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16. A new lethal chondrodysplasia with platyspondyly, long bone angulation and mixed bone density

Author

Hall Cm, Berry Ac, Mary J. Seller, McLennan A, and Maxwell Dj

Subjects
musculoskeletal diseases, Fetus, animal structures, Bone density, Autosomal recessive inheritance, business.industry, Ossification, Long bone, General Medicine, Anatomy, musculoskeletal system, Pathology and Forensic Medicine, Skull, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Medicine, Platyspondyly, medicine.symptom, Skeletal abnormalities, business, Genetics (clinical)
Abstract

A fetus diagnosed by sonography at 20 weeks' gestation had multiple skeletal abnormalities. The main features were absent ossification of the skull and cervical and upper thoracic vertebral bodies; short, angulated femora, tibiae, radii and ulnae but normal humeri; platyspondyly; trident-shaped acetabular roofs; sclerotic bands on the iliac wings and scapulae; clavicular hooks; and overall, mixed bone density. We suggest that this is a new chondrodysplasia which, since the parents are first cousins, could follow autosomal recessive inheritance.

Published
1996

17. Wolcott-Rallison syndrome

Author

Azzam A, Makia S, Lihadh Al-Gazali, and Hall Cm

Subjects
Pediatrics, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Pathology and Forensic Medicine, Dysplasia, Diabetes mellitus, Insulin dependent diabetes, Pediatrics, Perinatology and Child Health, medicine, Anatomy, business, Wolcott–Rallison syndrome, Genetics (clinical), Early onset
Abstract

Two sibs with early onset diabetes and epiphysed dysplasia (Wolcott-Rallison syndrome) are described. The epiphyseal changes were radiologically apparent at 6 months of age in one of them, and both developed insulin dependent diabetes in the first few weeks of life. The clinical and radiological features of this syndrome are reviewed.

Published
1995

18. Temperature taking in children.

Author

Molton AH, Blacktop J, and Hall CM

Abstract

Tempa-Dot single-use thermometers have been compared with mercury and tympanic thermometers in a paediatric setting.The largest difference in mean temperature measured between devices was less than 0.2 degrees C.Differences between devices are less than the random scatter in any individual measurement.It is argued that differences in measured temperature between thermometers are not clinically significant.Tempa-Dot thermometers can be used with confidence to measure the temperatures of young children. [ABSTRACT FROM AUTHOR]

Published
2001
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20. Maximum Compliance and Ménière's Disease

Author

Hall Cm

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine.disease, Cochlea, Compliance (physiology), Acoustic Impedance Tests, Otorhinolaryngology, Ear, Inner, Humans, Medicine, business, Meniere Disease, Meniere's disease
Published
1978

34. Safety of hospital discharge before return of bowel function after elective colorectal surgery

Author

J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de Ven, Poelman, M, Lps, Stassen, Slooter, G, Yiz, Acherman, Hoff, C, F Gerhards, M, Mwj, Stommel, J Hazebroek, E, Aaw van Geloven, A Schasfoort, R, L van Leeuwen, B, B Tuynman, J, Mwa van Tilburg, G Boerma, E, Sharma, P, Jenkins, B, P Bissett, I, Herd, A, Gordon, A, Vernon, D, Omundsen, M, J, Ly, Reddy, A, Bonnet, G, Harmston, C, Morales, M, Francisco, V, Costa, S, Manso, A, Amorim, E, Pereira, J, Cardoso, J, Ourô, S, Caratão, M, Nascimento, C, B Ribeiro da Silva, Taranu, V, Dias, R, Mendes, J, Allen, M, Silva, A, Carlos, S, Barbosa, E, Carneiro, C, Ramos, L, Lencastre, L, Martins, R, Silva-Vaz, P, F Ridgway, P, A McNamara, D, Cahill, R, Hogan, A, Larkin, J, R O'Connell, P, Negoi, I, Abelevich, A, M Ćuk, V, Vician, M, Ede, C, Sardiwalla, I, Mulira, S, Montwedi, D, Oyomno, M, Sabia, D, V Portugal Porras, Vigorita, V, G Sanz Ortega, García, J, A Espí Macías, F Blanco Antona, A Luján Mompeán, J, S Salvans Ruiz, Villarejo-Campos, P, M Romero Simó, Sánchez-Guillén, L, M Jiménez-Gómez, L, A Sánchez López, Golda, T, D Julià Bergkvist, Nevado, C, F Noguera Aguilar, J, B Ricardo Felipe, Septiem, J, A Rodríguez Sánchez, Cañete-Gómez, J, I Ruiz Montesinos, Millán-Scheiding, M, Prieto-Nieto, I, Frasson, M, D García Olmo, Hübner, M, Petermann, D, O Sauvain, M, Ozben, V, E Geçim, I, Disçi, E, Rencuzogullari, A, Kurt, A, Bisgin, T, Pehlivan, M, Isik, A, Onur, E, Leventoglu, S, C Haksal, M, S Erturk, M, Keskin, M, Guner, A, S Tutcu Sahin, S Ozbalci, G, Pergel, A, Albayrak, D, Bruce, D, Fearnhead, N, Arthur, J, Harron, M, Beattie, G, Titu, L, Saunders, M, Phillips, J, Dindyal, S, Cresswell, B, Gercek, Y, Lee, J, Linn, T, Faulkner, G, Lockwood, S, Rees, J, Charalabopoulos, A, Campbell, B, Kontovounisios, C, Amarnath, T, Johnson, M, Epanomeritakis, E, Vigs, S, Nastro, P, Gilliam, A, Smolarek, S, Wilson, T, Orbell, J, Mcintyre, R, Agarwal, T, Hainsworth, P, Patel, P, Vijay, J, Liu, B, P Dhruva Rao, Roxburgh, C, Vipond, M, Youssef, H, Thorn, C, Schizas, A, Denley, S, Bowley, D, Das, K, Cuming, T, Saha, A, Chung, L, Pitt, J, Davis, P, Jones, O, Taylor, M, Bhargava, A, Haji, A, Watson, N, Bloom, I, Singh, B, Norwood, M, Gurjar, S, Stylianides, N, Mirza, S, Evans, M, Williams, G, Patil, P, Hernon, J, Finch, G, Green, S, Chapple, K, Fafemi, O, Warusavitarne, J, Samee, A, Carden, C, Ong, L, Verma, K, Joseph, A, Rawat, N, Pinkney, T, Oke, O, Glen, P, Maxwell-Armstrong, C, Oliphant, R, Garner, J, J Moug, S, Middleton, S, N Lund, J, J Smart, N, Osborn, G, Moore, T, Raymond, T, H Knowles, C, S Hany, T, Clarke, R, Khera, G, Brady, R, Sellahewa, C, Mason, C, Torrance, A, Lasithiotakis, K, Knight, J, Pullybank, A, Ainsworth, P, Reid, F, Ramwell, A, Maslekar, S, George, R, Skull, A, Holtham, S, Muhammad, K, Lal, R, Varcada, M, M Smith, F, Howlader, M, Defriend, D, Kirk, S, Richards, T, Evans, C, M Borg, C, Telford, K, Sarfraz, N, Busby, K, Hollingshead, J, Speake, D, Pawa, N, West, D, Chadwick, M, Komolafe, O, Richardson, S, Thornton, M, Goede, A, Osborne, C, Bandyopadhyay, D, Foong, J, J Lee, Y, Liebenberg, P, Mijalkov, D, Wells, A, Bull, N, Ajmera, A, Warburton, T, Morgan, S, Mahmoud, A, Schachtel, M, Mikhail, B, Fomin, I, Mekaeil, B, Taylor, N, Stevenson, C, Drane, A, Pahalawatta, U, T Lai, L, Debiasio, A, Hjs, Jun, Hengpoonthana, R, M Mendis, D, M Robb, P, J Lee, H, Aab, Wyche, T Davis, L, Chrimes, A, Agarwal, A, Zhao, J, Williams, S, Jmsn, Jayalath, Khor, S, Muddasani, T, Childs, S, Ridgway, S, Nda, Blefari, Tam, H, Puchalski, N, Ngai, C, Mackenzie, J, Johnson, N, Holmes, M, Zuzek, R, Saluja, T, Gould, T, K Goh, Y, Selvaraj, T, Z Beh, Y, N Dudi-Venkata, N, Horne, D, L Borrow, J, Campbell, C, Cousins, G, Jackson, L, Maheepala, K, Zhao, S, Holden, E, Tutt, L, Thompson, B, Collins, H, Louie, F, Buckland, B, Smith, D, Chong, C, H Chua, T, Nayak, C, Redmond, J, R Tan, R, Gramlick, M, S Teh, J, Y Ng, S, Britten-Jones, P, R Mohd Rosli, Hdv, Pham, Jegathees, T, Smcj, Coulter-Nile, P Gosselink, M, L Wang, Y, Maciaszek, M, S Chrapko, P, Nair, A, Thirugnanasundralingam, V, 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Subjects
operative, Male, postoperative discharge, Postoperative Complications, 0302 clinical medicine, Colostomy, CRITERIA, Prospective Studies, Bowel function, Colectomy, IMAGINE, stoma, intestines, Proctectomy, Ileostomy, digestive, oral, and skin physiology, patient discharge, colorectal surgery, hospital discharge, bowel function, RECOVERY, Middle Aged, adult, colostomy, elective surgical procedures, female, follow-up studies, humans, ileostomy, ileus, male, middle aged, multivariate analysis, patient readmission, patient safety, postoperative complications, prospective studies, recovery of function, colectomy, proctectomy, Patient Discharge, Colorectal surgery, ileus - - discharge - bowel function - elective - colorectal surgery, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Patient Safety, Cohort study, safety, Adult, medicine.medical_specialty, Ileus, Patient Readmission, defecation, 03 medical and health sciences, medicine, Hospital discharge, Humans, colorectal surgery, colorectal resection, Colorectal resection, defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus, business.industry, Recovery of Function, Odds ratio, medicine.disease, digestive system diseases, surgical procedures, Surgery, Multivariate Analysis, Defecation, business, Follow-Up Studies
Abstract

Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.

Published
2020

38. A new familial case of spondylo-epi-metaphyseal dysplasia with multiple dislocations Hall type (leptodactylic form)

Author

Gianfranco Sebastio, Daniele De Brasi, Antonella Battagliese, Generoso Andria, Daniela Melis, Christine Hall, Massimiliano Rossi, Rossi, M, DE BRASI, Daniele, Hall, Cm, Battagliese, A, Melis, Daniela, Sebastio, Gianfranco, and Andria, Generoso

Subjects
Adult, Male, Hand deformity, Foot Deformities, Congenital, business.industry, Spondylo epi metaphyseal dysplasia, Body height, Infant, General Medicine, Anatomy, Osteochondrodysplasias, medicine.disease, Body Height, Pathology and Forensic Medicine, MULTIPLE DISLOCATIONS, Familial case, Dysplasia, Pediatrics, Perinatology and Child Health, Humans, Medicine, business, Hand Deformities, Congenital, Genetics (clinical)
Abstract

We report a father and son affected by spondylo-epi-metaphyseal dysplasia with multiple dislocations (Hall type), also called leptodactylic form. This family contributes to the delineation of the clinical and radiological phenotype of this rare condition.

Published
2005

39. Clinical phenotype of lathosterolosis

Author

Paola Ferrari, Mariarosaria Cervasio, Ida Parisi, Giancarlo Parenti, Francesco Rivasi, Raffaella Vecchione, Gaetano Corso, Fiorella Balli, Maria D'Armiento, Generoso Andria, Christine Hall, Massimiliano Rossi, Rossi, M, D'Armiento, Maria, Parisi, I, Ferrari, P, Hall, Cm, Cervasio, M, Rivasi, F, Balli, F, Vecchione, Raffaela, Corso, G, Andria, G, Parenti, G., and Vecchione, R

Subjects
Male, Oxidoreductases Acting on CH-CH Group Donors, medicine.medical_specialty, Pathology, Appendicular skeleton, butterfly vertebra, Biology, Lamellar granule, neural tube defect, Lipid Metabolism, Inborn Errors, Congenital Abnormalities, storage, Smith-Lemli-Opitz syndrome, Internal medicine, Genetics, medicine, Humans, Craniofacial, Child, lathosterolosis, Niemann-Pick type C, Genetics (clinical), Fetus, polydactyly, Neural tube defect, Lathosterolosis, medicine.disease, Phenotype, Smith-Lemli-Opitz Syndrome, Cholesterol, Endocrinology, medicine.anatomical_structure, Child, Preschool, Female, Niemann–Pick disease
Abstract

Lathosterolosis (LS) is a defect of cholesterol biosynthesis due to the deficiency of the enzyme sterol-C5-desaturase. Only two patients have been described to date, both presenting with multiple malformations, mental retardation, and liver involvement. In addition in one of them pathological examination revealed mucolipidosis-like inclusions on optic microscopy analysis, and peculiar lysosomal lamellar bodies on electron microscopy analysis. This study is focused on a better characterization of the clinical phenotype of LS. We describe a further case in a fetus, sibling of the first patient reported, presenting with neural tube defect, craniofacial and limb anomalies, and prenatal liver involvement. The fetal phenotype suggests the possible occurrence of significant intrafamilial variability in LS, and expands the phenotypic spectrum of the disease. Histological examination of autopsy samples from the fetus and skin fibroblasts from the living sibling suggested that the mucolipidosis-like picture previously reported is not a constant feature of LS, being possibly associated with the most severe biochemical defects, but confirmed the ultrastructural finding of lamellar inclusions. The LS phenotype appears to be characterized by the distinctive association of a recognizable pattern of congenital anomalies, involving axial and appendicular skeleton, liver, central nervous and urogenital systems, and lysosomal storage. This condition partially overlaps with other defects of sterol metabolism, suggesting intriguing pathogenic links among these conditions.

Published
2007

40. Spondyloepimetaphyseal dysplasia with multiple dislocations (Hall type): three further cases and evidence of autosomal dominant inheritance

Author

Amaka C. Offiah, Christine Hall, N H Elcioglu, Robin M. Winter, K D MacDermot, Hall, CM, Elcioglu, NH, MacDermot, KD, Offiah, AC, and Winter, RM

Subjects
Spondyloepiphyseal dysplasia, medicine.medical_specialty, Spondyloepimetaphyseal dysplasia, Genetic heterogeneity, business.industry, Stridor, SPONASTRIME DYSPLASIA, Anatomy, medicine.disease, Osteochondrodysplasia, Endocrinology, Dysplasia, Internal medicine, Arthropathy, Genetics, medicine, medicine.symptom, business, Metaphyseal irregularity, Genetics (clinical), Letter to JMG
Abstract

Three additional patients, including a father and daughter, with spondyloepimetaphyseal dysplasia and multiple dislocations are presented. This is the first report of dominant inheritance, with variable intrafamilial expressivity of this disorder. All patients showed facial dysmorphism with a short, broad, upturned nose. There were striking epiphyseal and metaphyseal changes of the long bones and joint laxity with multiple dislocations of the large joints, which were particularly incapacitating at the knees. This skeletal dysplasia showed some overlapping features with SPONASTRIME dysplasia, but with the addition of epiphyseal changes with abnormal articular bone modelling and premature osteoarthritis. The spondyloepimetaphyseal dysplasias (SEMD) are a large group of disorders of variable severity, classified by their clinical and radiological manifestations. They are a genetically heterogeneous group of disorders.1,2 A recently delineated form is SEMD with multiple dislocations (MIM 603546).3 This is characterised by a generalised epiphyseal dysplasia, gracile metacarpals, a small carpus, and mild platyspondyly with vertebral end plate irregularity. SPONASTRIME dysplasia, first described by Fanconi et al 4 in 1983, was further delineated by Langer et al in 19975 and falls into the SMD group of disorders. The word “SPONASTRIME” is a mnemonic from spo ndylar and na sal changes with stri ations of the me taphyses. Patients with SPONASTRIME dysplasia show striking midface and nasal hypoplasia. Characteristic changes in the shape of the vertebral bodies with time are the most consistent diagnostic criteria. Inheritance is autosomal recessive. Patients with SEMD with multiple dislocations and patients with SPONASTRIME dysplasia both have metaphyseal irregularity and develop sclerotic, short, longitudinal striations in the metaphyses. ### Case 1 Case 1 was the first child of healthy, unrelated parents of normal stature. Birth weight was 3100 g at 41 weeks’ gestation following induction of labour and a normal delivery. There was stridor soon after birth and at …

Published
2002

41. Safety and efficacy of ABT-089 in pediatric attention-deficit/hyperactivity disorder: results from two randomized placebo-controlled clinical trials.

Author

Wilens TE, Gault LM, Childress A, Kratochvil CJ, Bensman L, Hall CM, Olson E, Robieson WZ, Garimella TS, Abi-Saab WM, Apostol G, Saltarelli MD, Wilens, Timothy E, Gault, Laura M, Childress, Ann, Kratochvil, Christopher J, Bensman, Lindsey, Hall, Coleen M, Olson, Evelyn, and Robieson, Weining Z

Abstract

Objective: To assess the safety and efficacy of ABT-089, a novel α(4)β(2) neuronal nicotinic receptor partial agonist, vs. placebo in children with attention-deficit/hyperactivity disorder (ADHD).Method: Two multicenter, randomized, double-blind, placebo-controlled, parallel-group studies of children 6 through 12 years of age were conducted. Study 1 (n = 274) assessed six treatment groups over 8 weeks: 4 once-daily (QD) ABT-089 doses (0.085-0.700 mg/kg), QD atomoxetine, and placebo. Study 2 (n = 119) assessed three treatment groups over 6 weeks: 2 QD ABT-089 doses (0.7 mg/kg, 1.4 mg/kg) and placebo. The primary efficacy variable was the investigator-administered Attention-Deficit/Hyperactivity Disorder Rating Scale-IV: Home Version (ADHD-RS-IV [HV]) Total Score. Safety was assessed by adverse event (AE) monitoring, laboratory tests, vital signs, physical examinations, and electrocardiogram measures.Results: There was no statistically significant difference between ABT-089 and placebo in mean change from baseline to final evaluation of ADHD-RS-IV (HV) Total Score or other outcome measures at any dose in either study. In Study 1, atomoxetine showed statistically significant improvement for the primary and most secondary endpoints. ABT-089 was generally safe and well tolerated, with no statistically significant difference between any ABT-089 dose and placebo in the overall incidence of any specific AE, and no clinically significant changes in other safety measures.Conclusions: ABT-089 did not show efficacy on the primary efficacy variable, the ADHD-RS-IV (HV) Total Score, or other measures of ADHD symptomatology in children with ADHD, and had a safety profile similar to placebo. These results contrast with published reports of efficacy of nicotinic modulators in adults with ADHD. [ABSTRACT FROM AUTHOR]

Published
2011
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42. Destination Restaurants' Practices and the Production of Locality: The Case of Michelin Restaurants in China.

Author

Huang Y, Hall CM, and Chen NC

Abstract

Dining plays a pivotal role in the travel experience, with numerous studies identifying the significant impacts of restaurant attributes on tourists' destination experiences and their sense of place. The identified attributes include the origin of food produce, menu design, the physical and social servicescape, and restaurant reputation, all of which have the potential to enhance customers' sense of place. Therefore, based on theories of the production of locality, this study explores how destination restaurants "put place on the plate" and identifies how destination restaurants promote place. Semi-structured interviews were conducted with the representatives of seventeen Michelin (one star, two stars, three stars, and Bib Gourmand)-awarded restaurants across Mainland China. The results reveal three primary strategies employed by destination restaurants in promoting place: forging partnerships with the local community to produce, present, and reproduce localities; leveraging local knowledge embedded in the local produce, recipes, cooking techniques, and local culture; and practicing translocality to introduce a regional cuisine to diverse and cosmopolitan consumers. This research provides a comprehensive understanding of the way in which notions of locality and place are used by destination restaurants and the way in which this may promote not only restaurants but also regional culinary cultures and destination attractiveness.

Published
2024
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43. The sphingosine 1-phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus.

Author

Magalhães DM, Stewart NA, Mampay M, Rolle SO, Hall CM, Moeendarbary E, Flint MS, Sebastião AM, Valente CA, Dymond MK, and Sheridan GK

Subjects
Animals, Mice, Male, Sphingosine analogs & derivatives, Sphingosine pharmacology, Sphingosine metabolism, Lysophospholipids metabolism, Lipid Metabolism drug effects, Immunosuppressive Agents pharmacology, Fingolimod Hydrochloride pharmacology, Hippocampus drug effects, Hippocampus metabolism, Lipidomics, Mice, Inbred C57BL
Abstract

The small-molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1-phosphate (S1P) analogue currently used to treat relapsing-remitting multiple sclerosis in both adults and children. FTY720 can cross the blood-brain barrier (BBB) and, over time, accumulate in lipid-rich areas of the central nervous system (CNS) by incorporating into phospholipid membranes. FTY720 has been shown to enhance cell membrane fluidity, which can modulate the functions of glial cells and neuronal populations involved in regulating behaviour. Moreover, direct modulation of S1P receptor-mediated lipid signalling by FTY720 can impact homeostatic CNS physiology, including neurotransmitter release probability, the biophysical properties of synaptic membranes, ion channel and transmembrane receptor kinetics, and synaptic plasticity mechanisms. The aim of this study was to investigate how chronic FTY720 treatment alters the lipid composition of CNS tissue in adolescent mice at a key stage of brain maturation. We focused on the hippocampus, a brain region known to be important for learning, memory, and the processing of sensory and emotional stimuli. Using mass spectrometry-based lipidomics, we discovered that FTY720 increases the fatty acid chain length of hydroxy-phosphatidylcholine (PCOH) lipids in the mouse hippocampus. It also decreases PCOH monounsaturated fatty acids (MUFAs) and increases PCOH polyunsaturated fatty acids (PUFAs). A total of 99 lipid species were up-regulated in the mouse hippocampus following 3 weeks of oral FTY720 exposure, whereas only 3 lipid species were down-regulated. FTY720 also modulated anxiety-like behaviours in young mice but did not affect spatial learning or memory formation. Our study presents a comprehensive overview of the lipid classes and lipid species that are altered in the hippocampus following chronic FTY720 exposure and provides novel insight into cellular and molecular mechanisms that may underlie the therapeutic or adverse effects of FTY720 in the central nervous system., (© 2024 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.)

Published
2024
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44. Survey shows all surgical residents have exposure to robotic surgery yet no formalized curricula exist amongst programs: A Southwest Surgical Congress Survey.

Author

Jeffery CS, Stewart KE, Hayhurst JL, Hall CM, Regner JL, and Raines AR

Subjects
Humans, Education, Medical, Graduate methods, Curriculum, Surveys and Questionnaires, Internship and Residency, Robotic Surgical Procedures education, Robotics, General Surgery education
Abstract

Background: Increased robotic surgery exposure during general surgery training occurs at many institutions without a formal education curriculum. Our study evaluates the current state of general surgery robotic training within programs represented by the Southwestern Surgical Congress (SWSC)., Methods: A web-based survey regarding robot-assisted surgery (RAS) and general surgery training was developed and sent to member institutions of the SWSC. General surgery program directors were asked to voluntarily complete the survey. Results were evaluated in aggregate. Descriptive analysis was used., Results: In total, 28 programs responded. All reported resident exposure to RAS during training. Case mix was diverse with exposure to multiple general surgical subspecialties. 89% of programs reported the presence of a formal RAS curriculum, however, only 53% reported recognition of training completion. Case volumes also varied amongst programs with 46% of programs reporting residents logging 21-40 cases and 35% logging more than 40 cases in total., Conclusion: Exposure to RAS among SWSC residency programs is ubiquitous, however, there is significant variation between programs in case volumes, case types, and elements of RAS curricula., Competing Interests: Declaration of competing interest We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Published by Elsevier Inc.)

Published
2023
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45. Energizing tourism sustainably: A harmonious symphony of tourists' and locals' acceptance of renewable energy.

Author

Hateftabar F and Hall CM

Subjects
Renewable Energy, Sustainable Development, Tourism, Knowledge
Abstract

This review paper explores the acceptance of renewable energy (RE) installations and projects, focusing on the perspectives of local residents and tourists. While previous research has extensively examined community acceptance of RE, limited attention has been given to tourists' acceptance in tourist destinations. Despite extensive research, significant gaps persist, particularly regarding tourists' acceptance of RE installations. The paper stresses the need to identify the determinants of tourists' acceptance and advocates for further investigation comparing residents' and tourists' reactions to RE projects in tourism destinations. It also emphasizes the importance of incorporating new theories and interdisciplinary approaches into future studies. By offering an overview of existing research and providing guidance for future inquiry, this review paper contributes to the body of knowledge on RE acceptance. It underscores the necessity of comprehensively examining the acceptance of both local residents and tourists to ensure sustainable development and the integration of RE projects in tourism destinations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)

Published
2023
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46. Efficacy of the Fast Track Friendship Group Program for Peer-rejected Children: A Randomized-Controlled Trial.

Author

Bierman KL, Welsh JA, Hall CM, Jacobson LN, Lee DL, and Jones DE

Subjects
Child, Humans, Male, Female, Social Behavior, Peer Group, Social Skills, Friends, Interpersonal Relations
Abstract

Objective: To evaluate the benefits of the Fast Track Friendship Group program implemented as a stand-alone school-based intervention on the social cognitions, social behavior, peer and teacher relationships of peer-rejected students., Method: Over four successive years, 224 peer-rejected elementary students (57% White, 17% Black, 20% Latinx, 5% multiracial; 68% male; grades 1-4; M age  = 8.1 years old) were identified using peer sociometric nominations and randomly assigned to the intervention (n = 110) or a treatment-as-usual control group (n = 114). Four school districts serving economically-disadvantaged urban and rural communities participated. Intervention involved weekly small group social skills training with classmate partners, with sessions tailored to address individual child needs. Consultation meetings held at the start and mid-point of intervention were designed to help teachers and parents support the generalization of targeted skills., Results: Multi-level linear models, with children nested within schools (controlling for demographics and baseline scores) documented improvements in social-cognitive skills (direct assessments of emotion recognition and competent social problem-solving), social behavior (teacher ratings of social skills and externalizing behavior), and interpersonal relationships (peer sociometric nominations of peer acceptance and friendships, teacher-rated student-teacher closeness). Significant effects were generally small ( d s = .19-.36) but consistent across child sex, grade level, and behavioral characteristics., Conclusions: The intervention proved feasible for high-fidelity implementation in school settings and produced significant improvements in the social adjustment of peer-rejected children, validating the approach as a school-based Tier 2 intervention.

Published
2023
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48. On the post-pandemic travel boom: How capacity building and smart tourism technologies in rural areas can help - evidence from Iran.

Author

Torabi ZA, Rezvani MR, Hall CM, and Allam Z

Abstract

While there have been numerous studies investigating the impact of the COVID-19 pandemic on tourism, few research projects have examined the impact of the outbreak on using smart tourism technologies (STT), especially in developing countries. This study adopted thematic analysis, with data collected using in-person interviews. The participants for the study were selected using the snow-balling technique. We explored the process of developing smart technologies during the pandemic and its impact on smart rural tourism technology development upon travel restart. The subject was investigated by focusing on five selected villages in central Iran which have tourism dependent economies. Overall, the results indicated that the pandemic partially changed the government's resistance towards the fast development of smart technologies. Thus, the role of smart technologies in curbing the virus spread was officially recognized. This change of policy led to the implementation of Capacity Building (CB) programs to improve digital literacy and minimize the digital gap that exists between urban and rural areas in Iran. Implementing CB programs during the pandemic directly and indirectly contributed to the digitalization of rural tourism. Implementing such programs enhanced tourism stakeholders' individual and institutional capacity to gain access to and creatively use STT in rural area. The results of this study improve our understanding and knowledge of the impact of crises on the degree of acceptability and use of STT in traditional rural societies., (© 2023 Elsevier Inc. All rights reserved.)

Published
2023
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49. Hippocampus of the APP NL-G-F mouse model of Alzheimer's disease exhibits region-specific tissue softening concomitant with elevated astrogliosis.

Author

Hall CM, Lasli S, Serwinski B, Djordjevic B, Sheridan GK, and Moeendarbary E

Abstract

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer's disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain occur alongside changes in the mechanical properties of brain tissue, as reported in recent magnetic resonance elastography (MRE) measurements of human brain mechanics. Whilst MRE has many advantages, a significant shortcoming is its spatial resolution. Higher resolution "cellular scale" assessment of the mechanical alterations to brain regions involved in memory formation, such as the hippocampus, could provide fresh new insight into the etiology of AD. Characterization of brain tissue mechanics at the cellular length scale is the first stepping-stone to understanding how mechanosensitive neurons and glia are impacted by neurodegenerative disease-associated changes in their microenvironment. To provide insight into the microscale mechanics of aging brain tissue, we measured spatiotemporal changes in the mechanical properties of the hippocampus using high resolution atomic force microscopy (AFM) indentation tests on acute brain slices from young and aged wild-type mice and the APP NL-G-F mouse model. Several hippocampal regions in APP NL-G-F mice are significantly softer than age-matched wild-types, notably the dentate granule cell layer and the CA1 pyramidal cell layer. Interestingly, regional softening coincides with an increase in astrocyte reactivity, suggesting that amyloid pathology-mediated alterations to the mechanical properties of brain tissue may impact the function of mechanosensitive astrocytes. Our data also raise questions as to whether aberrant mechanotransduction signaling could impact the susceptibility of neurons to cellular stressors in their microenvironment., Competing Interests: BS and BD were employed by 199 Biotechnologies Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Hall, Lasli, Serwinski, Djordjevic, Sheridan and Moeendarbary.)

Published
2023
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50. Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei.

Author

Hall CM, Somprasong N, Hagen JP, Nottingham R, Sahl JW, Webb JR, Mayo M, Currie BJ, Podin Y, Wagner DM, Keim P, and Schweizer HP

Subjects
Gram-Negative Bacteria, Cephalosporins pharmacology, Cephalosporins therapeutic use, Drug Resistance, Multiple, Bacterial genetics, Microbial Sensitivity Tests, Cefiderocol, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Burkholderia pseudomallei
Abstract

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia., Competing Interests: The authors declare no conflict of interest.

Published
2023
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