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1. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Roynon, A, Northfield, J, Winchester, S, Cieciwa, P, Pai, A, Bakker, P, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Osuji, N, Chitalia, N, Bailey, T, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Brake, S, Gunn, J, Selassi, A, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Lewis, T, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Aeron-Thomas, J, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Shah, A, Russell, J, Brennan, D, Dave, A, Chawla, A, Westwell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Horsley, A, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Flanagan, D, Dhasmana, D, Fowler, S, Cameron, E, Prentice, L, Sinclair, C, Bateman, V, McLelland-Brooks, K, Ho, A, Murphy, M, Cochrane, A, Gibson, A, Black, K, Tempeton, K, Donaldson, S, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Cross, A, Mirfenderesky, M, Joyce, S, Sinanovic, I, Howard, M, Cowling, P, Brazil, M, Hanna, E, Abdelrazik, A, Brand, S, Sheridan, EA, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Browne, D, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Warren, S, Brooking, D, Pai, S, Druyeh, R, Smith, E, Stone, S, Meisner, S, Delgado, D, Underhill, E, Keen, L, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Birch, S, DeSilva, T, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Painter, Sharen, Price, C, Pepperell, J, James, K, Trinick, T, Moore, L, Day, J, Boulos, A, Knox, I, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Bain, SC, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, White, N, Longfellow, R, Hughes, LE, Green, ME, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Hilton, D, Powell, J, Jackson, A, Plant, AJ, Ahmed, N, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, RE, Donaghy, T, O'Kane, M, Shipman, K, Sierra, R, Parmar, C, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Saei, Ayoub, Andrews, Nick, Oguti, Blanche, Charlett, Andre, Wellington, Edgar, Stowe, Julia, Gillson, Natalie, Atti, Ana, Islam, Jasmin, Karagiannis, Ioannis, Munro, Katie, Khawam, Jameel, Chand, Meera A, Brown, Colin S, Ramsay, Mary, Lopez-Bernal, Jamie, and Hopkins, Susan

Published
2021
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2. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Winchester, S, Cieciwa, P, Pai, A, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Botes, D, Chitalia, N, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Callens, C, Beazer, S, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Gantert, K, Russell, J, Brennan, D, Dave, A, Chawla, A, Westell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Ingram, S, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Reeks, C, Fowler, S, Prentice, L, Spears, M, McKerron, G, McLelland-Brooks, K, Anderson, J, Donaldson, S, Templeton, K, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Mirfenderesky, M, Cross, A, Price, J, Joyce, S, Sinanovic, I, Howard, M, Lewis, T, Cowling, P, Potoczna, D, Brand, S, Sheridan, L, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Penny-Thomas, K, Pai, S, Zamikula, J, Smith, E, Stone, S, Boldock, E, Howcroft, D, Thompson, C, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Marsh, L, Tazzyman, S, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Jones, A, Price, C, Pepperell, J, Schultz, M, Day, J, Boulos, A, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, Staines, N, Longfellow, R, Green, ME, Hughes, LE, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Jory, H, Virgilio, E, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, R, Donaghy, T, Shipman, K, Sierra, R, Jones, N, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, De Silva, T, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Charlett, Andre, Atti, Ana, Monk, Edward J M, Simmons, Ruth, Wellington, Edgar, Cole, Michelle J, Saei, Ayoub, Oguti, Blanche, Munro, Katie, Wallace, Sarah, Kirwan, Peter D, Shrotri, Madhumita, Vusirikala, Amoolya, Rokadiya, Sakib, Kall, Meaghan, Zambon, Maria, Ramsay, Mary, Brooks, Tim, Brown, Colin S, Chand, Meera A, and Hopkins, Susan

Published
2021
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3. Adapting COVID-19 research infrastructure to capture Influenza and Respiratory Syncytial Virus alongside SARS-CoV-2 in UK healthcare workers Winter 2022/23 and beyond: protocol for a pragmatic sub-study

Author

Broad, Jon, primary, Sparkes, Dominic, additional, Platt, Naomi, additional, Howells, Anna, additional, Foulkes, Sarah, additional, Khawam, Jameel, additional, cole, michelle, additional, Andrews, nick, additional, Watson, Conall, additional, Hopkins, Susan, additional, and Hall, Victoria Jane, additional

Published
2023
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4. Antibody Correlates of Protection Against Delta Infection after Vaccination: A Nested Case-Control within the UK-Based Siren Study

Author

Atti, Ana, primary, Insalata, Ferdinando, additional, Carr, Edward J., additional, Otter, Ashley, additional, Foulkes, Sarah, additional, Wu, Mary Y., additional, Cole, Michelle, additional, Linley, Ezra, additional, Semper, Amanda, additional, Brooks, Tim, additional, Hopkins, Susan, additional, Charlett, Andre, additional, Beale, Rupert, additional, and Hall, Victoria Jane, additional

Published
2023
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5. Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020

Author

Hall, Victoria Jane, Foulkes, Sarah, Charlett, Andre, Atti, Ana, Monk, Edward JM, Simmons, Ruth, Wellington, Edgar, Cole, Michelle, Saei, Ayoub, Oguti, Blanche, Munro, Katie, Wallace, S, Kirwan, Peter, Shrotri, Madhumita, Vusirikala, Amoolya, Rokadiya, Sakib, Kall, Meaghan, Zambon, Maria, Ramsay, Mary, Brooks, T, Group, SIREN Study, Brown, Colin, Chand, Meera, Hopkins, Susan, Shrotri, Madhumita [0000-0001-9791-122X], Hopkins, Susan [0000-0001-5179-5702], and Apollo - University of Cambridge Repository

Abstract

Background: There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection.Methods: A large multi-centre prospective cohort was recruited from publicly funded hospital staff in the UK. Participants attended regular SARS-CoV-2 PCR and antibody testing (every 2-4 weeks) and completed fortnightly questionnaires on symptoms and exposures. At enrolment, participants were assigned to either the positive cohort (antibody positive or prior PCR/antibody test positive) or negative cohort (antibody negative, not previously known to be PCR/antibody positive). Potential reinfections were clinically reviewed and classified according to case definitions (confirmed, probable, possible (subdivided by symptom-status)) depending on hierarchy of evidence. Individuals in the primary infection were excluded from this analysis if infection was confirmed by antibody only. Reinfection rates in the positive cohort were compared against new PCR positives in the negative cohort using a mixed effective multivariable logistic regression analysis.Findings: Between 18 June and 09 November 2020, 44 reinfections (2 probable, 42 possible) were detected in the baseline positive cohort of 6,614 participants, collectively contributing 1,339,078 days of follow-up. This compares with 318 new PCR positive infections and 94 antibody seroconversions in the negative cohort of 14,173 participants, contributing 1,868,646 days of follow-up. The incidence density per 100,000 person days between June and November 2020 was 3.2 reinfections in the positive cohort, compared with 22.4 new PCR confirmed infections in the negative cohort. The adjusted odds ratio was 0.17 for all reinfections (95% CI 0.13-0.24) compared to PCR confirmed primary infections. The median interval between primary infection and reinfection was over 160 days.Interpretation: A prior history of SARS-CoV-2 infection was associated with an 83% lower risk of infection, with median protective effect observed five months following primary infection. This is the minimum likely effect as seroconversions were not included.Trial Registration: Trial registered with ISRCTN, Trial ID: ISRCTN11041050. https://www.isrctn.com/ISRCTN11041050.Funding Statement: Department of Health and Social Care and Public Health England, with contributions from the Scottish, Welsh and Northern Irish governments.Declaration of Interests: No conflicts of interest declared.Ethics Approval Statement: IRAS ID 284460, Berkshire Research Ethics Committee, Health Research Authority and Health and Care Research Wales approval granted 22 May 2020.

Published
2022
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6. Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study

Author

Moore, Shona, primary, Kronsteiner, Barbara, additional, Longet, Stephanie, additional, Adele, Sandra, additional, Deeks, Alexandra, additional, Liu, Chang, additional, Dejnirattisai, Wanwisa, additional, Silva Reyes, Laura, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Tipton, Tom, additional, Hering, Luisa M., additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Nicols, Alexander R., additional, Dobson, Sue L., additional, Supasa, Piyada, additional, Tuekprakhon, Aekkachai, additional, Cross, Andrew, additional, Tyerman, Jessica K., additional, Hornsby, Hailey, additional, Grouneva, Irina, additional, Plowright, Megan, additional, Zhang, Peijun, additional, Newman, Thomas, additional, Nell, Jeremy M., additional, Abraham, Priyanka, additional, Ali, Mohammad, additional, Malone, Tom, additional, Neale, Isabel, additional, Phillips, Eloise, additional, Wilson, Joseph D., additional, Murray, Sam M., additional, Shields, Adrian, additional, Horner, Emily C., additional, Booth, Lucy H., additional, Stafford, Lizzie, additional, Bibi, Sagida, additional, Wootton, Dan G., additional, Mentzer, Alexander J., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa C., additional, Pollard, Andrew J., additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolspaya, Juthathip, additional, Payne, Rebecca P., additional, Dold, Christina, additional, Lambe, Teresa, additional, Thaventhiran, James, additional, Screaton, Gavin R., additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria Jane, additional, Duncan, Christopher JA, additional, Richter, Alex G., additional, Carroll, Miles W., additional, de Silva, Thushan I., additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Turtle, Lance, additional, and Consortium, PITCH, additional

Published
2022
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7. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Chand, Meera A, additional, Brown, Colin S, additional, Ramsay, Mary, additional, Lopez-Bernal, Jamie, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Roynon, A, additional, Northfield, J, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Bakker, P, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes,, T, additional, Jones, C, additional, Osuji, N, additional, Chitalia, N, additional, Bailey, T, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Brake, S, additional, Gunn, J, additional, Selassi, A, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Lewis, T, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Aeron-Thomas, J, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Shah, A, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westwell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Horsley, A, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Flanagan, D, additional, Dhasmana, D, additional, Fowler, S, additional, Cameron, E, additional, Prentice, L, additional, Sinclair, C, additional, Bateman, V, additional, McLelland-Brooks, K, additional, Ho, A, additional, Murphy, M, additional, Cochrane, A, additional, Gibson, A, additional, Black, K, additional, Tempeton, K, additional, Donaldson, S, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Cross, A, additional, Mirfenderesky, M, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Cowling, P, additional, Brazil, M, additional, Hanna, E, additional, Abdelrazik, A, additional, Brand, S, additional, Sheridan, EA, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Browne, D, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Warren, S, additional, Brooking, D, additional, Pai, S, additional, Druyeh, R, additional, Smith, E, additional, Stone, S, additional, Meisner, S, additional, Delgado, D, additional, Underhill, E, additional, Keen, L, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Birch, S, additional, DeSilva, T, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Painter, Sharen, additional, Price, C, additional, Pepperell, J, additional, James, K, additional, Trinick, T, additional, Moore, L, additional, Day, J, additional, Boulos, A, additional, Knox, I, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Bain, SC, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, White, N, additional, Longfellow, R, additional, Hughes, LE, additional, Green, ME, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Hilton, D, additional, Powell, J, additional, Jackson, A, additional, Plant, AJ, additional, Ahmed, N, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, RE, additional, Donaghy, T, additional, O'Kane, M, additional, Shipman, K, additional, Sierra, R, additional, Parmar, C, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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8. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward J M, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle J, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, Sarah, additional, Kirwan, Peter D, additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary, additional, Brooks, Tim, additional, Brown, Colin S, additional, Chand, Meera A, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes, T, additional, Jones, C, additional, Botes, D, additional, Chitalia, N, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Callens, C, additional, Beazer, S, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Gantert, K, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Ingram, S, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Reeks, C, additional, Fowler, S, additional, Prentice, L, additional, Spears, M, additional, McKerron, G, additional, McLelland-Brooks, K, additional, Anderson, J, additional, Donaldson, S, additional, Templeton, K, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Mirfenderesky, M, additional, Cross, A, additional, Price, J, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Lewis, T, additional, Cowling, P, additional, Potoczna, D, additional, Brand, S, additional, Sheridan, L, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Penny-Thomas, K, additional, Pai, S, additional, Zamikula, J, additional, Smith, E, additional, Stone, S, additional, Boldock, E, additional, Howcroft, D, additional, Thompson, C, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Marsh, L, additional, Tazzyman, S, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Jones, A, additional, Price, C, additional, Pepperell, J, additional, Schultz, M, additional, Day, J, additional, Boulos, A, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, Staines, N, additional, Longfellow, R, additional, Green, ME, additional, Hughes, LE, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Jory, H, additional, Virgilio, E, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, R, additional, Donaghy, T, additional, Shipman, K, additional, Sierra, R, additional, Jones, N, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, De Silva, T, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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9. T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study

Author

Angyal, Adrienn, primary, Longet, Stephanie, additional, Moore, Shona, additional, Payne, Rebecca P., additional, Harding, Adam, additional, Tipton, Tom, additional, Rongkard, Patpong, additional, Ali, Mohammad, additional, Hering, Luisa M., additional, Meardon, Naomi, additional, Austin, James, additional, Brown, Rebecca, additional, Skelly, Donal, additional, Gillson, Natalie, additional, Dobson, Sue L., additional, Cross, Andrew, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A., additional, Tyerman, Jessica K., additional, Nicols, Alexander R., additional, Spegarova, Jarmila S., additional, Mehta, Hema, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Goulder, Philip, additional, Frater, John, additional, Dold, Christina, additional, Pace, Matthew, additional, Ogbe, Ane, additional, Brown, Helen, additional, Ansari, Azim M., additional, Adland, Emily, additional, Brown, Anthony, additional, Chand, Meera A., additional, Shields, Adrian, additional, Matthews, Philippa, additional, Hopkins, Susan, additional, Hall, Victoria Jane, additional, James, William, additional, Rowland-Jones, Sarah L., additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, Richter, Alex G., additional, Duncan, Christopher J. A., additional, Barnes, Eleanor, additional, Carroll, Miles W., additional, Turtle, Lance, additional, de Silva, Thushan I., additional, and Consortium, PITCH, additional

Published
2021
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10. Effectiveness of BNT162b2 mRNA Vaccine Against Infection and COVID-19 Vaccine Coverage in Healthcare Workers in England, Multicentre Prospective Cohort Study (the SIREN Study)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Group, The SIREN Study, additional, Chand, Meera A., additional, Brown, Colin, additional, Ramsay, Mary E., additional, Bernal, Jamie Lopez, additional, and Hopkins, Susan, additional

Published
2021
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11. Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA Vaccine

Author

Payne, Rebecca P., primary, Longet, Stephanie, additional, Austin, James A., additional, Skelly, Donal, additional, Dejnirattisai, Wanwisa, additional, Adele, Sandra, additional, Meardon, Naomi, additional, Faustini, Sian, additional, Al-Taei, Saly, additional, Moore, Shona, additional, Tipton, Tom, additional, Hering, Luisa M., additional, Angyal, Adrienn, additional, Brown, Rebecca, additional, Gillson, Natalie, additional, Dobson, Sue L., additional, Amini, Ali, additional, Supasa, Piyada, additional, Cross, Andrew, additional, Sandhar, Gurjinder, additional, Kilby, Jonathan A., additional, Tyerman, Jessica K., additional, Nicols, Alexander R., additional, Altmann, Thomas, additional, Hornsby, Hailey, additional, Whitham, Rachel, additional, Phillips, Eloise, additional, Malone, Tom, additional, Hargreaves, Alexander, additional, Shields, Adrian, additional, Saei, Ayoub, additional, Foulkes, Sarah, additional, Stafford, Lizzie, additional, Johnson, Síle, additional, Wootton, Dan G., additional, Conlon, Christopher P., additional, Jeffery, Katie, additional, Matthews, Philippa, additional, Frater, John, additional, Deeks, Alexandra, additional, Dold, Christina, additional, Pollard, Andrew, additional, Brown, Anthony, additional, Rowland-Jones, Sarah L., additional, Mongkolsapaya, Juthathip, additional, Barnes, Eleanor, additional, Hopkins, Susan, additional, Hall, Victoria Jane, additional, Duncan, Christopher J. A., additional, Richter, Alex G., additional, Carroll, Miles W., additional, Screaton, Gavin R., additional, de Silva, Thushan I., additional, Turtle, Lance, additional, Klenerman, Paul, additional, Dunachie, Susanna, additional, and Consortium, The PITCH, additional

Published
2021
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12. Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers? Large Multi-Centre Prospective Cohort Study (The SIREN Study), England: June to November 2020

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward JM, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, S., additional, Kirwan, Peter D., additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary E., additional, Brooks, T., additional, Group, SIREN Study, additional, Brown, Colin, additional, Chand, Meera A., additional, and Hopkins, Susan, additional

Published
2021
Full Text
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