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3. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

van den Heuvel, Martijn P, Scholtens, Lianne H, van der Burgh, Hannelore K, Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon JNL, Beyer, Frauke, Booij, Linda, Braun, Kees PJ, Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M, Chaim-Avancini, Tiffany M, Chan, Sandra SM, Chen, Eric YH, Crespo-Facorro, Benedicto, Crone, Eveline A, Dannlowski, Udo, de Zwarte, Sonja MC, Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Díaz-Caneja, Covadonga M, Díaz-Zuluaga, Ana M, Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M, Holleran, Laurena, Holt, Rosemary, Hopman, Helene J, Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn GJC, Kostic, Vladimir S, Krug, Axel, Lawrie, Stephen M, Lebedeva, Irina S, Lee, Edwin HM, Lett, Tristram A, Lewis, Simon JG, Liem, Franziskus, Lombardo, Michael V, Lopez-Jaramillo, Carlos, Margulies, Daniel S, Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meinert, Susanne L, Menchón, José M, Montag, Christian, Moreira, Pedro S, Morgado, Pedro, Mothersill, David O, Mérillat, Susan, Müller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, de la Foz, Victor Ortiz-Garcia, Peper, Jiska S, Pineda, Julian A, Rasser, Paul E, Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro GP, Ruigrok, Amber NV, Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S, Tordesillas-Gutierrez, Diana, Valk, Sofie L, and van den Berg, Leonard H

Subjects
Biological Psychology, Psychology, Biomedical Imaging, Brain Disorders, Neurosciences, Neurological, MRI, connectome analysis, diffusion weighted MRI, brain, network, Clinical Sciences, Clinical sciences, Biological psychology
Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

Published
2019

11. Motor cortical excitability and pre-supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity

Author

Todd, Gabrielle, Rae, Caroline D., Taylor, Janet L., Rogasch, Nigel C., Butler, Jane E., Hayes, Michael, Wilcox, Robert A., Gandevia, Simon C., Aoun, Karl, Esterman, Adrian, Lewis, Simon J. G., Hall, Julie M., Matar, Elie, Godau, Jana, Berg, Daniela, Plewnia, Christian, von Thaler, Anna-Katharina, Chiang, Clarence, Double, Kay L., Todd, Gabrielle, Rae, Caroline D., Taylor, Janet L., Rogasch, Nigel C., Butler, Jane E., Hayes, Michael, Wilcox, Robert A., Gandevia, Simon C., Aoun, Karl, Esterman, Adrian, Lewis, Simon J. G., Hall, Julie M., Matar, Elie, Godau, Jana, Berg, Daniela, Plewnia, Christian, von Thaler, Anna-Katharina, Chiang, Clarence, and Double, Kay L.

Abstract

Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50 – 70 years is associated with reduced short-interval intracortical inhibition in primary motor cortex, and that the reduced intracortical inhibition is associated with neurochemical markers of activity in the pre-supplementary motor area (pre-SMA). Short-interval intracortical inhibition and intracortical facilitation in primary motor cortex was assessed with paired-pulse transcranial magnetic stimulation in 23 healthy adults with normal (n = 14; 61 ± 7 yrs) or abnormally enlarged (hyperechogenic; n = 9; 60 ± 6 yrs) area of SN echogenicity. Thirteen of these participants (7 SN − and 6 SN+) also underwent brain magnetic resonance spectroscopy to investigate pre-SMA neurochemistry. There was no relationship between area of SN echogenicity and short-interval intracortical inhibition in the ipsilateral primary motor cortex. There was a significant positive relationship, however, between area of echogenicity in the right SN and the magnitude of intracortical facilitation in the right (ipsilateral) primary motor cortex (p = .005; multivariate regression), evidenced by the amplitude of the conditioned motor evoked potential (MEP) at the 10 – 12 ms interstimulus interval. This relationship was not present on the left side. Pre-SMA glutamate did not predict primary motor cortex inhibition or facilitation. The results suggest that SN hyperechogenicity in healthy older adults may be associated with changes in excitability of motor cortical circuitry. The results advance understanding of brain changes in healthy older adults at risk of Parkinson's disease.

Published
2023

13. Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity

Author

Todd, Gabrielle, primary, Rae, Caroline D., additional, Taylor, Janet L., additional, Rogasch, Nigel C., additional, Butler, Jane E., additional, Hayes, Michael, additional, Wilcox, Robert A., additional, Gandevia, Simon C., additional, Aoun, Karl, additional, Esterman, Adrian, additional, Lewis, Simon J. G., additional, Hall, Julie M., additional, Matar, Elie, additional, Godau, Jana, additional, Berg, Daniela, additional, Plewnia, Christian, additional, von Thaler, Anna‐Katharina, additional, Chiang, Clarence, additional, and Double, Kay L., additional

Published
2022
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19. A Developmental Neuroimaging Investigation of the Change Paradigm

Author

Thomas, Laura A., Hall, Julie M., and Skup, Martha

Abstract

This neuroimaging study examines the development of cognitive flexibility using the Change task in a sample of youths and adults. The Change task requires subjects to inhibit a prepotent response and substitute an alternative response, and the task incorporates an algorithm that adjusts task difficulty in response to subject performance. Data from both groups combined show a network of prefrontal and parietal areas that are active during the task. For adults vs. youths, a distributed network was more active for successful change trials versus go, baseline, or unsuccessful change trials. This network included areas involved in rule representation, retrieval (lateral PFC), and switching (medial PFC and parietal regions). These results are consistent with data from previous task-switching experiments and inform developmental understandings of cognitive flexibility. (Contains 4 tables and 5 figures.)

Published
2011
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20. Erratum: 'The Role of Dietary Phytoestrogens and the Nuclear Receptor PPAR[gamma] in Adipogenesis: An in Vitro Study'

Author

Hall, Julie M., Powell, Heather R., Rajic, Lara, and Korach, Kenneth S.

Subjects
Isoflavones, Estrogens, Health, Environmental issues, Health
Abstract

In this article, an author's name was incorrectly listed as Heather A. Powell. The author's correct name is Heather R. Powell. The author list has been corrected in the original [...]

Published
2019
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28. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Author

Malone, Robert W., primary, Tisdall, Philip, additional, Fremont-Smith, Philip, additional, Liu, Yongfeng, additional, Huang, Xi-Ping, additional, White, Kris M., additional, Miorin, Lisa, additional, Moreno, Elena, additional, Alon, Assaf, additional, Delaforge, Elise, additional, Hennecker, Christopher D., additional, Wang, Guanyu, additional, Pottel, Joshua, additional, Blair, Robert V., additional, Roy, Chad J., additional, Smith, Nora, additional, Hall, Julie M., additional, Tomera, Kevin M, additional, Shapiro, Gideon, additional, Mittermaier, Anthony, additional, Kruse, Andrew C., additional, García-Sastre, Adolfo, additional, Roth, Bryan L., additional, Glasspool-Malone, Jill, additional, and Ricke, Darrell O., additional

Published
2021
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30. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Author

Malone, Robert W., primary, Tisdall, Philip, additional, Fremont-Smith, Philip, additional, Liu, Yongfeng, additional, Huang, Xi-Ping, additional, White, Kris M., additional, Miorin, Lisa, additional, Olmo, Elena Moreno Del, additional, Alon, Assaf, additional, Delaforge, Elise, additional, Hennecker, Christopher D., additional, Wang, Guanyu, additional, Pottel, Joshua, additional, Smith, Nora, additional, Hall, Julie M., additional, Shapiro, Gideon, additional, Mittermaier, Anthony, additional, Kruse, Andrew C., additional, García-Sastre, Adolfo, additional, Roth, Bryan L., additional, Glasspool-Malone, Jill, additional, and Ricke, Darrell O., additional

Published
2020
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37. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, de Lange, Siemon C., van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, and de Lange, Siemon C.

Published
2019

38. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

Onderzoeksgroep 6, Projectafdeling ALS, Brain, MS Neonatologie, Child Health, ZL Kinder Ner en Nec Medisch, Onderzoek, Ontwikkelingsstoornissen Ond., Onderzoek Bob Oranje, Onderzoeksgroep 1, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, Psychiatrie_Medisch, van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, de Lange, Siemon C., Onderzoeksgroep 6, Projectafdeling ALS, Brain, MS Neonatologie, Child Health, ZL Kinder Ner en Nec Medisch, Onderzoek, Ontwikkelingsstoornissen Ond., Onderzoek Bob Oranje, Onderzoeksgroep 1, ZL Neuromusculaire Ziekten Medisch, Regenerative Medicine and Stem Cells, Psychiatrie_Medisch, van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, Booij, Linda, Braun, Kees P. J., Busatto Filho, Geraldo, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, de Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Durston, Sarah, Diaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H. M., Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V, Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martinez-Zalacain, Ignacio, McDonald, Calm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchon, Jose M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Merillat, Susan, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G. P., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Cares, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., van den Berg, Leonard H., van Erp, Theo G. M., van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus, V, Zhang, Rui, and de Lange, Siemon C.

Published
2019

39. 10kin1day:A bottom-up neuroimaging initiative

Author

Van Den Heuvel, Martijn P., Scholtens, Lianne H., Van Der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J.N.L., Beyer, Frauke, Booij, Linda, Braun, Kees P.J., Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S.M., Chen, Eric Y.H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, De Zwarte, Sonja M.C., Dietsche, Bruno, Donohoe, Gary, Plessis, Stefan Du, Durston, Sarah, Díaz-Caneja, Covadonga M., Díaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G.J.C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H.M., Lett, Tristram A., Lewis, Simon J.G., Liem, Franziskus, Lombardo, Michael V., Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchón, José M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Mérillat, Susan, Müller, Hans Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, De la Foz, Victor Ortiz Garcia, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G.P., Ruigrok, Amber N.V., Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., Van Den Berg, Leonard H., Van Erp, Theo G.M., Van Haren, Neeltje E.M., Van Leeuwen, Judith M.C., Villringer, Arno, Vinkers, Christiaan H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, De Lange, Siemon C., Van Den Heuvel, Martijn P., Scholtens, Lianne H., Van Der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J.N.L., Beyer, Frauke, Booij, Linda, Braun, Kees P.J., Filho, Geraldo Busatto, Cahn, Wiepke, Cannon, Dara M., Chaim-Avancini, Tiffany M., Chan, Sandra S.M., Chen, Eric Y.H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, De Zwarte, Sonja M.C., Dietsche, Bruno, Donohoe, Gary, Plessis, Stefan Du, Durston, Sarah, Díaz-Caneja, Covadonga M., Díaz-Zuluaga, Ana M., Emsley, Robin, Filippi, Massimo, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gąsecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jäncke, Lutz, Kaleda, Vasiliy G., Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G.J.C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina S., Lee, Edwin H.M., Lett, Tristram A., Lewis, Simon J.G., Liem, Franziskus, Lombardo, Michael V., Lopez-Jaramillo, Carlos, Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne L., Menchón, José M., Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Mérillat, Susan, Müller, Hans Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Naumczyk, Patrycja, Oranje, Bob, De la Foz, Victor Ortiz Garcia, Peper, Jiska S., Pineda, Julian A., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Rosa, Pedro G.P., Ruigrok, Amber N.V., Sabisz, Agnieszka, Schall, Ulrich, Seedat, Soraya, Serpa, Mauricio H., Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, Tomyshev, Alexander S., Tordesillas-Gutierrez, Diana, Valk, Sofie L., Van Den Berg, Leonard H., Van Erp, Theo G.M., Van Haren, Neeltje E.M., Van Leeuwen, Judith M.C., Villringer, Arno, Vinkers, Christiaan H., Vollmar, Christian, Waller, Lea, Walter, Henrik, Whalley, Heather C., Witkowska, Marta, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, and De Lange, Siemon C.

Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain. Ongoing grand-scale projects like the European Human Brain Project (1), the US Brain Initiative (2), the Human Connectome Project (3), the Chinese Brainnetome (4) and exciting world-wide neuroimaging collaborations such as ENIGMA (5) herald the new era of big neuroscience. In conjunction with these major undertakings, there is an emerging trend for bottom-up initiatives, starting with small-scale projects built upon existing collaborations and infrastructures. As described by Mainen et al. (6), these initiatives are centralized around self-organized groups of researchers working on the same challenges and sharing interests and specialized expertise. These projects could scale and open up to a larger audience and other disciplines over time, eventually lining up and merging their findings with other programs to make the bigger picture.

Published
2019

40. 10Kin1day: A bottom-up neuroimaging initiative

Author

Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, and Martínez-Zalacaín, Ignacio

Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

Published
2019

46. Cognitive training for freezing of gait in Parkinson's disease: a randomized controlled trial

Author

Walton, Courtney C, Mowszowski, Loren, Gilat, Moran, Hall, Julie M, O'Callaghan, Claire, Muller, Alana J, Georgiades, Matthew, Szeto, Jennifer YY, Ehgoetz Martens, Kaylena A, Shine, James M, Naismith, Sharon L, Lewis, Simon JG, Walton, Courtney C [0000-0003-0835-2310], Lewis, Simon JG [0000-0002-4093-7071], and Apollo - University of Cambridge Repository

Subjects
Aging, Parkinson's Disease, 6.6 Psychological and behavioural, FOS: Clinical medicine, Clinical Trials and Supportive Activities, Neurosciences, 1103 Clinical Sciences, Neurodegenerative, Brain Disorders, Clinical, Clinical Medicine and Science, Mental Health, Clinical Research, Behavioral and Social Science, Neurological, Acquired Cognitive Impairment, Mind and Body
Abstract

The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in Parkinson's disease (PD). This study aimed to explore whether targeted CT can reduce the severity of FoG in PD. Patients with PD who self-reported FoG and were free from dementia were randomly allocated to receive either a CT intervention or an active control. Both groups were clinician-facilitated and conducted twice-weekly for seven weeks. The primary outcome was percentage of time spent frozen during a Timed Up and Go task, assessed both on and off dopaminergic medications. Secondary outcomes included multiple neuropsychological and psychosocial measures. A full analysis was first conducted on all participants randomized, followed by a sample of interest including only those who had objective FoG at baseline, and completed the intervention. Sixty-five patients were randomized into the study. The sample of interest included 20 in the CT group and 18 in the active control group. The primary outcome of percentage time spent frozen during a gait task was significantly improved in the CT group compared to active controls in the on-state. There were no differences in the off-state. Patients who received CT also demonstrated improved processing speed and reduced daytime sleepiness compared to those in the active control. The findings suggest that CT can reduce the severity of FoG in the on-state, however replication in a larger sample is required.

Published
2018
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47. Evidence for subtypes of freezing of gait in Parkinson's disease

Author

Ehgoetz Martens, Kaylena A, Shine, James M, Walton, Courtney C, Georgiades, Matthew J, Gilat, Moran, Hall, Julie M, Muller, Alana J, Szeto, Jennifer YY, and Lewis, Simon JG

Subjects
cognitive, Science & Technology, Freezing of gait, Parkinson's disease, Clinical Neurology, limbic, Neurosciences & Neurology, heterogeneity, Life Sciences & Biomedicine, affective, motor, SCALE
Abstract

BACKGROUND: The purpose of this study is to identify and characterize subtypes of freezing of gait by using a novel questionnaire designed to delineate freezing patterns based on self-reported and behavioral gait assessment. METHODS: A total of 41 Parkinson's patients with freezing completed the Characterizing Freezing of Gait questionnaire that identifies situations that exacerbate freezing. This instrument underwent examination for construct validity and internal consistency, after which a data-driven clustering approach was employed to identify distinct patterns amongst individual responses. Behavioral freezing assessments in both dopaminergic states were compared across 3 identified subgroups. RESULTS: This novel questionnaire demonstrated construct validity (severity scores correlated with percentage of time frozen; r = 0.54) and internal consistency (Cronbach's α = .937), and thus demonstrated promising utility for identifying patterns of freezing that are independently related to motor, anxiety, and attentional impairments. CONCLUSIONS: Patients with freezing may be dissociable based on underlying neurobiological underpinnings that would have significant implications for targeting future treatments. © 2018 International Parkinson and Movement Disorder Society. ispartof: Movement Disorders vol:33 issue:7 pages:1174-1178 ispartof: location:United States status: published

Published
2018

48. Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson's disease: A Randomised Controlled Trial

Author

Gilat, Moran, primary, Coeytaux Jackson, Alessandra, additional, Marshall, Nathaniel S., additional, Hammond, Deborah, additional, Mullins, Anna E., additional, Hall, Julie M., additional, Fang, Bernard A.M., additional, Yee, Brendon J., additional, Wong, Keith K.H., additional, Grunstein, Ron R., additional, and Lewis, Simon J. G., additional

Published
2019
Full Text
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