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6. Evaluation of Communities That Care-Effects on Municipal Youth Crime Rates in Victoria, Australia: 2010–2019

Author

Rowland, Bosco Charles, Kelly, Adrian, Mohebbi, Mohammadreza, Kremer, Peter, Abraham, Charles, Abimanyi-Ochom, Julie, Carter, Robert, Williams, Joanne, Smith, Rachel, Osborn, Amber, Hall, Jessica K., Hosseini, Tina, Renner, Heidi, Toumbourou, John Winston, Rowland, Bosco Charles, Kelly, Adrian, Mohebbi, Mohammadreza, Kremer, Peter, Abraham, Charles, Abimanyi-Ochom, Julie, Carter, Robert, Williams, Joanne, Smith, Rachel, Osborn, Amber, Hall, Jessica K., Hosseini, Tina, Renner, Heidi, and Toumbourou, John Winston

Abstract

Internationally, youth crime is a significant social problem. Violent youth crime has been rising over the past decade in the state of Victoria, Australia. Communities That Care (CTC) is a coalition training process designed to prevent youth crime. There has been limited evaluation outside the United States. Using a non-experimental design, this study employed official state crime statistics to evaluate the impact on crime as the 5-phase CTC process was implemented between 2010 and 2019 across communities in Victoria. The standard five-phase CTC implementation cycle was supplemented with universal programs to reduce sales and supply of alcohol to underage (under 18 year old) youth. Growth models evaluated community trends in youth crime (all, person, property and other), comparing communities that implemented CTC at phase 3 or greater with communities that had not implemented CTC. In accord with the hypotheses, the study found significant reductions in crimes over the period between 2010 and 2019. A 2% annual reduction in risk was observed for crimes against persons for all age groups IRR=0.98; 95CI: 0.96—0.998) . A 5% annual reduction was observed for crimes of property and deception for adolescents aged between 10 to 17 years (IRR=0.95; 95CI: 0.90—0.99). These findings support CTC as an intervention for preventing youth crime at a population level. Future studies should evaluate intervention mechanisms and economic benefits.

Published
2022

8. Additional file 1 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Author

Jordan, Kimberly R., Hall, Jessica K., Schedin, Troy, Borakove, Michelle, Xian, Jenny J., Dzieciatkowska, Monika, Lyons, Traci R., Pepper Schedin, Hansen, Kirk C., and Borges, Virginia F.

Abstract

Additional file 1. Clinical Characteristics of Enrolled Patients, study subject information.

Published
2020
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9. Additional file 4 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Author

Jordan, Kimberly R., Hall, Jessica K., Schedin, Troy, Borakove, Michelle, Xian, Jenny J., Dzieciatkowska, Monika, Lyons, Traci R., Pepper Schedin, Hansen, Kirk C., and Borges, Virginia F.

Abstract

Additional file 4. Proteins identified by volcano plot comparing EVs from healthy donors and YWBC patients, tabulated data of the volcano plot shown in Fig. 3.

Published
2020
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10. Additional file 3 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Author

Jordan, Kimberly R., Hall, Jessica K., Schedin, Troy, Borakove, Michelle, Xian, Jenny J., Dzieciatkowska, Monika, Lyons, Traci R., Pepper Schedin, Hansen, Kirk C., and Borges, Virginia F.

Abstract

Additional file 3. EVs isolated from different subsets of YWBC patients increased invasion of MCF10DCIS.com breast cancer cells, clinical characteristics of functional EVs shown in Fig. 2.

Published
2020
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15. Triple Targeting of Breast Tumors Driven by Hormonal Receptors and HER2.

Author

Shagisultanova E, Crump LS, Borakove M, Hall JK, Rasti AR, Harrison BA, Kabos P, Lyons TR, and Borges VF

Subjects
Animals, Female, Humans, Mice, Mice, Inbred NOD, Protein Kinase Inhibitors pharmacology, Breast Neoplasms drug therapy, Protein Kinase Inhibitors therapeutic use, Receptors, Estrogen therapeutic use
Abstract

Breast cancers that express hormonal receptors (HR) and HER2 display resistance to targeted therapy. Tumor-promotional signaling from the HER2 and estrogen receptor (ER) pathways converges at the cyclin D1 and cyclin-dependent kinases (CDK) 4 and 6 complex, which drives cell-cycle progression and development of therapeutic resistance. Therefore, we hypothesized that co-targeting of ER, HER2, and CDK4/6 may result in improved tumoricidal activity and suppress drug-resistant subclones that arise on therapy. We tested the activity of the triple targeted combination therapy with tucatinib (HER2 small-molecule inhibitor), palbociclib (CKD4/6 inhibitor), and fulvestrant (selective ER degrader) in HR + /HER2 + human breast tumor cell lines and xenograft models. In addition, we evaluated whether triple targeted combination prevents growth of tucatinib or palbociclib-resistant subclones in vitro and in vivo Triple targeted combination significantly reduced HR + /HER2 + tumor cell viability, clonogenic survival, and in vivo growth. Moreover, survival of HR + /HER2 + cells that were resistant to the third drug in the regimen was reduced by the other two drugs in combination. We propose that a targeted triple combination approach will be clinically effective in the treatment of otherwise drug-resistant tumors, inducing robust responses in patients., (©2021 The Authors; Published by the American Association for Cancer Research.)

Published
2022
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