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Your search keyword '"Haling JR"' showing total 13 results

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1. Anti-tumor efficacy of a potent and selective non-covalent KRAS G12D inhibitor.

2. EndoBind detects endogenous protein-protein interactions in real time.

3. Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.

4. Design and Discovery of N -(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

5. Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

6. Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

7. Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

8. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.

9. Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

10. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.

11. Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

12. An experimentally derived database of candidate Ras-interacting proteins.

13. Infants of mothers with megaloblastic anemia due to folate deficiency.

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