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Infrared (IR) lasers have recently been tested as an alternative to electrosurgical and ultrasonic laparoscopic devices for optical sealing of blood vessels. IR laser technology previously demonstrated faster sealing times, reduced thermal spread, and lower device temperatures during experimental studies. However, current commercial laparoscopic devices incorporate electrical impedance and/or temperature sensors as real-time, closed-loop, feedback to indicate successful blood vessel seals. This preliminary study explores an infrared laser system for sealing and optical coherence tomography (OCT) as a potential feedback system for successful vessel seal verification. A 1470-nm diode laser delivered an incident power of 30 W for an irradiation time of 5 s using an 8 × 2 mm linear beam, for creating strong seals in porcine renal blood vessels under compression. After sealing the blood vessels, OCT was performed on unsealed and sealed vessel regions for comparison. Standard vessel burst pressure (BP) measurements confirmed successful seals after OCT. Integrated reflectance intensity in OCT A-scans decreased by an average of 20 ± 6% in sealed versus native vessels of 2.4 ± 0.4 mm diameter. Vessel BP measured 532 ± 239 mmHg, with all vessels (n = 25) recording a successful BP > 180 mmHg (hypertensive blood pressure). Unsealed vessels demonstrated significantly deeper imaging marked by a continuous decay in reflected intensity, while sealed vessels showed subsurface reflectance intensity peaks, immediately followed by a rapid decay in reflectance intensity. These markers are consistent with increased light scattering and decreased optical penetration depth upon thermal coagulation of tissues. A-line OCT data consistently differentiated between sealed and unsealed blood vessel regions. Future work will involve OCT integration into the laparoscopic device for real-time optical feedback during IR laser sealing.