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2. Low‐dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation

Author

Oberkofler, Christian E, Raptis, Dimitri A, Müller, Philip C, da Silva, Richard X Sousa, Lehmann, Kuno, Ito, Takahiro, Owen, Timothy, Pollok, Joerg‐Matthias, Parente, Alessandro, Schlegel, Andrea, Peralta, Peregrina, Winter, Erin, Selzner, Markus, Fodor, Margot, Maglione, Manuel, Jaklitsch, Manuel, Marques, Hugo P, Chavez‐Villa, Mariana, Contreras, Alan, Kron, Philipp, Lodge, Peter, Alford, Scott, Rana, Abbas, Magistri, Paolo, Di Benedetto, Fabrizio, Johnson, Bethany, Kirchner, Varvara, Bauldrick, Francis, Halazun, Karim J, Ghamarnedjad, Omid, Mehrabi, Arianeb, Basto, Samanta Teixeira, Fernandes, Eduardo SM, Paladini, Jose, de Santibañes, Martin, Florman, Sander, Tabrizian, Parissa, Dutkowski, Philipp, Clavien, Pierre‐Alain, Busuttil, Ronald W, Kaldas, Fady M, and Petrowsky, Henrik

Subjects
Digestive Diseases, Liver Disease, Clinical Research, Transplantation, Organ Transplantation, Prevention, Adult, Humans, Liver Transplantation, Cohort Studies, Graft Rejection, Thrombosis, Allografts, Graft Survival, Retrospective Studies, Risk Factors, Clinical Sciences, Surgery
Abstract

This study investigated the effect of low-dose aspirin in primary adult liver transplantation (LT) on acute cellular rejection (ACR) as well as arterial patency rates. The use of low-dose aspirin after LT is practiced by many transplant centers to minimize the risk of hepatic artery thrombosis (HAT), although solid recommendations do not exist. However, aspirin also possesses potent anti-inflammatory properties and might mitigate inflammatory processes after LT, such as rejection. Therefore, we hypothesized that the use of aspirin after LT has a protective effect against ACR. This is an international, multicenter cohort study of primary adult deceased donor LT. The study included 17 high-volume LT centers and covered the 3-year period from 2013 to 2015 to allow a minimum 5-year follow-up. In this cohort of 2365 patients, prophylactic antiplatelet therapy with low-dose aspirin was administered in 1436 recipients (61%). The 1-year rejection-free survival rate was 89% in the aspirin group versus 82% in the no-aspirin group (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.63-0.94; p = 0.01). The 1-year primary arterial patency rates were 99% in the aspirin group and 96% in the no-aspirin group with an HR of 0.23 (95% CI, 0.13-0.40; p

Published
2022

4. Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors

Author

Adeniji, Nia, Arjunan, Vinodhini, Prabhakar, Vijay, Mannalithara, Ajitha, Ghaziani, Tara, Ahmed, Aijaz, Kwo, Paul, Nguyen, Mindie, Melcher, Marc L, Busuttil, Ronald W, Florman, Sander S, Haydel, Brandy, Ruiz, Richard M, Klintmalm, Goran B, Lee, David D, Taner, C Burcin, Hoteit, Maarouf A, Verna, Elizabeth C, Halazun, Karim J, Tevar, Amit D, Humar, Abhinav, Chapman, William C, Vachharajani, Neeta, Aucejo, Federico, Nydam, Trevor L, Markmann, James F, Mobley, Constance, Ghobrial, Mark, Langnas, Alan N, Carney, Carol A, Berumen, Jennifer, Schnickel, Gabriel T, Sudan, Debra L, Hong, Johnny C, Rana, Abbas, Jones, Christopher M, Fishbein, Thomas M, Agopian, Vatche, and Dhanasekaran, Renumathy

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Clinical Research, Liver Disease, Organ Transplantation, Transplantation, Rare Diseases, Cancer, Liver Cancer, Aging, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Aged, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Liver Transplantation, Middle Aged, Retrospective Studies, Risk Assessment, Survival Rate, United States, Surgery, Clinical sciences
Abstract

The incidence of hepatocellular carcinoma (HCC) is growing in the United States, especially among the elderly. Older patients are increasingly receiving transplants as a result of HCC, but the impact of advancing age on long-term posttransplant outcomes is not clear. To study this, we used data from the US Multicenter HCC Transplant Consortium of 4980 patients. We divided the patients into 4 groups by age at transplantation: 18 to 64 years (n = 4001), 65 to 69 years (n = 683), 70 to 74 years (n = 252), and ≥75 years (n = 44). There were no differences in HCC tumor stage, type of bridging locoregional therapy, or explant residual tumor between the groups. Older age was confirmed to be an independent and significant predictor of overall survival even after adjusting for demographic, etiologic, and cancer-related factors on multivariable analysis. A dose-response effect of age on survival was observed, with every 5-year increase in age older than 50 years resulting in an absolute increase of 8.3% in the mortality rate. Competing risk analysis revealed that older patients experienced higher rates of non-HCC-related mortality (P = 0.004), and not HCC-related death (P = 0.24). To delineate the precise cause of death, we further analyzed a single-center cohort of patients who received a transplant as a result of HCC (n = 302). Patients older than 65 years had a higher incidence of de novo cancer (18.1% versus 7.6%; P = 0.006) after transplantation and higher overall cancer-related mortality (14.3% versus 6.6%; P = 0.03). Even carefully selected elderly patients with HCC have significantly worse posttransplant survival rates, which are mostly driven by non-HCC-related causes. Minimizing immunosuppression and closer surveillance for de novo cancers can potentially improve the outcomes in elderly patients who received a transplant as a result of HCC.

Published
2021

5. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria: A Multicentric North American Experience

Author

Ivanics, Tommy, Claasen, Marco P.A.W., Samstein, Benjamin, Emond, Jean C., Fox, Alyson N., Pomfret, Elizabeth, Pomposelli, James, Tabrizian, Parissa, Florman, Sander S., Mehta, Neil, Roberts, John P., Emamaullee, Juliet A., Genyk, Yuri, Hernandez-Alejandro, Roberto, Tomiyama, Koji, Sasaki, Kazunari, Hashimoto, Koji, Nagai, Shunji, Abouljoud, Marwan, Olthoff, Kim M., Hoteit, Maarouf A., Heimbach, Julie, Taner, Timucin, Liapakis, AnnMarie H., Mulligan, David C., Sapisochin, Gonzalo, and Halazun, Karim J.

Published
2024
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7. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines

Author

Bonney, Glenn K, Chew, Claire Alexandra, Lodge, Peter, Hubbard, Joleen, Halazun, Karim J, Trunecka, Pavel, Muiesan, Paolo, Mirza, Darius F, Isaac, John, Laing, Richard W, Iyer, Shridhar Ganpathi, Chee, Cheng Ean, Yong, Wei Peng, Muthiah, Mark Dhinesh, Panaro, Fabrizio, Sanabria, Juan, Grothey, Axel, Moodley, Keymanthri, Chau, Ian, Chan, Albert C Y, Wang, Chih Chi, Menon, Krishna, Sapisochin, Gonzalo, Hagness, Morten, Dueland, Svein, Line, Pål-Dag, and Adam, René

Published
2021
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8. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria

Author

Ivanics, Tommy, Claasen, Marco P. A. W., Samstein, Benjamin, Emond, Jean C., Fox, Alyson N., Pomfret, Elizabeth, Pomposelli, James, Tabrizian, Parissa, Florman, Sander S., Mehta, Neil, Roberts, John P., Emamaullee, Juliet A., Genyk, Yuri, Hernandez-Alejandro, Roberto, Tomiyama, Koji, Sasaki, Kazunari, Hashimoto, Koji, Nagai, Shunji, Abouljoud, Marwan, Olthoff, Kim M., Hoteit, Maarouf A., Heimbach, Julie, Taner, Timucin, Liapakis, AnnMarie H., Mulligan, David C., Sapisochin, Gonzalo, Halazun, Karim J., Ivanics, Tommy, Claasen, Marco P. A. W., Samstein, Benjamin, Emond, Jean C., Fox, Alyson N., Pomfret, Elizabeth, Pomposelli, James, Tabrizian, Parissa, Florman, Sander S., Mehta, Neil, Roberts, John P., Emamaullee, Juliet A., Genyk, Yuri, Hernandez-Alejandro, Roberto, Tomiyama, Koji, Sasaki, Kazunari, Hashimoto, Koji, Nagai, Shunji, Abouljoud, Marwan, Olthoff, Kim M., Hoteit, Maarouf A., Heimbach, Julie, Taner, Timucin, Liapakis, AnnMarie H., Mulligan, David C., Sapisochin, Gonzalo, and Halazun, Karim J.

Abstract

Objective:To evaluate long-term oncologic outcomes of patients post-living donor liver transplantation (LDLT) within and outside standard transplantation selection criteria and the added value of the incorporation of the New York-California (NYCA) score.Background:LDLT offers an opportunity to decrease the liver transplantation waitlist, reduce waitlist mortality, and expand selection criteria for patients with hepatocellular carcinoma (HCC).Methods:Primary adult LDLT recipients between October 1999 and August 2019 were identified from a multicenter cohort of 12 North American centers. Posttransplantation and recurrence-free survival were evaluated using the Kaplan-Meier method.Results:Three hundred sixty LDLTs were identified. Patients within Milan criteria (MC) at transplantation had a 1, 5, and 10-year posttransplantation survival of 90.9%, 78.5%, and 64.1% versus outside MC 90.4%, 68.6%, and 57.7% (P = 0.20), respectively. For patients within the University of California San Francisco (UCSF) criteria, respective posttransplantation survival was 90.6%, 77.8%, and 65.0%, versus outside UCSF 92.1%, 63.8%, and 45.8% (P = 0.08). Fifty-three (83%) patients classified as outside MC at transplantation would have been classified as either low or acceptable risk with the NYCA score. These patients had a 5-year overall survival of 72.2%. Similarly, 28(80%) patients classified as outside UCSF at transplantation would have been classified as a low or acceptable risk with a 5-year overall survival of 65.3%.Conclusions:Long-term survival is excellent for patients with HCC undergoing LDLT within and outside selection criteria, exceeding the minimum recommended 5-year rate of 60% proposed by consensus guidelines. The NYCA categorization offers insight into identifying a substantial proportion of patients with HCC outside the MC and the UCSF criteria who still achieve similar post-LDLT outcomes as patients within the criteria.

Published
2024
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11. Living Donor Liver Transplantation (LDLT) for Hepatocellular Carcinoma (HCC) within and Outside Traditional Selection Criteria

Author

Ivanics, Tommy, primary, Claasen, Marco PAW, additional, Samstein, Benjamin, additional, Emond, Jean C, additional, Fox, Alyson N, additional, Pomfret, Elizabeth, additional, Pomposelli, James, additional, Tabrizian, Parissa, additional, Florman, Sander S, additional, Mehta, Neil, additional, Roberts, John P, additional, Emamaullee, Juliet A, additional, Genyk, Yuri, additional, Hernandez-Alejandro, Roberto, additional, Tomiyama, Koji, additional, Sasaki, Kazunari, additional, Quintini, Cristiano, additional, Nagai, Shunji, additional, Abouljoud, Marwan, additional, Olthoff, Kim M, additional, Hoteit, Maarouf A, additional, Heimbach, Julie, additional, Taner, Timucin, additional, Liapakis, AnnMarie H, additional, Mulligan, David C, additional, Sapisochin, Gonzalo, additional, and Halazun, Karim J, additional

Published
2023
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12. Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma: Analysis From the US Multicenter HCC Transplant Consortium

Author

DiNorcia, Joseph, Florman, Sander S., Haydel, Brandy, Tabrizian, Parissa, Ruiz, Richard M., Klintmalm, Goran B., Senguttuvan, Srinath, Lee, David D., Taner, C. Burcin, Verna, Elizabeth C., Halazun, Karim J., Hoteit, Maarouf, Levine, Matthew H., Chapman, William C., Vachharajani, Neeta, Aucejo, Federico, Nguyen, Mindie H., Melcher, Marc L., Tevar, Amit D., Humar, Abhinav, Mobley, Constance, Ghobrial, Mark, Nydam, Trevor L., Amundsen, Beth, Markmann, James F., Berumen, Jennifer, Hemming, Alan W., Langnas, Alan N., Carney, Carol A., Sudan, Debra L., Hong, Johnny C., Kim, Joohyun, Zimmerman, Michael A., Rana, Abbas, Kueht, Michael L., Jones, Christopher M., Fishbein, Thomas M., Markovic, Daniela, Busuttil, Ronald W., and Agopian, Vatche G.

Published
2020
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13. Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: analysis of the us multicenter hcc transplant consortium

Author

Tran, Benjamin V., primary, Moris, Dimitrios, additional, Markovic, Daniela, additional, Zaribafzadeh, Hamed, additional, Henao, Ricardo, additional, Lai, Quirino, additional, Florman, Sander S., additional, Tabrizian, Parissa, additional, Haydel, Brandy, additional, Ruiz, Richard M., additional, Klintmalm, Goran B., additional, Lee, David D., additional, Taner, C. Burcin, additional, Hoteit, Maarouf, additional, Levine, Matthew H., additional, Cillo, Umberto, additional, Vitale, Alessandro, additional, Verna, Elizabeth C., additional, Halazun, Karim J., additional, Tevar, Amit D., additional, Humar, Abhinav, additional, Chapman, William C., additional, Vachharajani, Neeta, additional, Aucejo, Federico, additional, Lerut, Jan, additional, Ciccarelli, Olga, additional, Nguyen, Mindie H., additional, Melcher, Marc L., additional, Viveiros, Andre, additional, Schaefer, Benedikt, additional, Hoppe-Lotichius, Maria, additional, Mittler, Jens, additional, Nydam, Trevor L., additional, Markmann, James F., additional, Rossi, Massimo, additional, Mobley, Constance, additional, Ghobrial, Mark, additional, Langnas, Alan N., additional, Carney, Carol A., additional, Berumen, Jennifer, additional, Schnickel, Gabriel T., additional, Sudan, Debra L., additional, Hong, Johnny C., additional, Rana, Abbas, additional, Jones, Christopher M., additional, Fishbein, Thomas M., additional, Busuttil, Ronald W., additional, Barbas, Andrew S., additional, and Agopian, Vatche G., additional

Published
2023
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18. Poor outcomes for children on the wait list at low-volume kidney transplant centers in the United States

Author

Rana, Abbas, Brewer, Eileen D., Scully, Brandi B., Kueht, Michael L., Goss, Matt, Halazun, Karim J., and Liu, Hao

Subjects
Kidneys -- Transplantation, Chronic kidney failure -- Patient outcomes, Hospitals -- Statistics -- Capacity -- United States, Pediatric research -- Statistics, Organ transplant recipients -- Patient outcomes -- Supply and demand
Abstract

Background Low case volume has been associated with worse survival outcomes in solid organ transplantation. Our aim was to analyze wait-list outcomes in conjunction with posttransplant outcomes. Methods We studied a cohort of 11,488 candidates waitlisted in the Organ Procurement and Transplantation Network (OPTN) for pediatric kidney transplant between 2002 and 2014, including both deceased- and living-donor transplants; 8757 (76 %) candidates received a transplant. Candidates were divided into four groups according to the average volume of yearly transplants performed in the listing center over a 12-year period: more than ten, six to nine, three to five, and fewer than three. We used multivariate Cox regression analysis to identify independent risk factors for wait list and posttransplant mortality. Results Twenty-seven percent of candidates were listed at low-volume centers in which fewer than three transplants were performed annually. These candidates had a limited transplant rate; only 49 % received a transplant versus 88 % in high-volume centers (more than ten transplants annually) (p < 0.001). Being listed at a low-volume center showed a fourfold increased risk for death while on the wait list [hazard ratio (HR) 4.0 in multivariate Cox regression and 6.1 in multivariate competing risk regression]. It was not a significant risk factor for posttransplant death in multivariate Cox regression. Conclusions Pediatric transplant candidates are listed at low-volume transplant centers are transplanted less frequently and have a much greater risk of dying while on the wait list. Further studies are needed to elucidate the reasons behind the significant outcome differences., Author(s): Abbas Rana [sup.1] [sup.2] , Eileen D. Brewer [sup.3] , Brandi B. Scully [sup.2] , Michael L. Kueht [sup.2] , Matt Goss [sup.2] , Karim J. Halazun [sup.4] , [...]

Published
2017
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20. Predicting Liver Allograft Discard: The Discard Risk Index

Author

Rana, Abbas, Sigireddi, Rohini R., Halazun, Karim J., Kothare, Aishwarya, Wu, Meng-Fen, Liu, Hao, Kueht, Michael L., Vierling, John M., Sussman, Norman L., Mindikoglu, Ayse L., Miloh, Tamir, Galvan, N. Thao N., Cotton, Ronald T., O’Mahony, Christine A., and Goss, John A.

Published
2018
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21. Proposal for a Worldwide Usable Score for the Prediction of Recurrence and Intention-to-Treat Survival after Liver Transplantation in Patients with Hepatocellular Cancer: A West-East Analysis on 1,903 Patients

Author

Lai, Quirino, Halazun, Karim J, Iesari, Samuele, Bhangui, Prashant, Finkenstedt, Armin, Mennini, Gianluca, Lin, Chih-Che, Hoppe-Lotichius, Maria, Ikegami, Toru, Xie, Qin-Fen, Zhe, Yang, Zheng, Shu-Sen, Soejima, Yuji, Otto, Gerd, Chen, Chao-Long, Rossi, Massimo, Graziadei, Ivo, Soin, Arvinder Singh, Emond, Jean C, and Lerut, Jan

Published
2018
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22. Impact of Pretransplant Bridging Locoregional Therapy for Patients With Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients From the US Multicenter HCC Transplant Consortium

Author

Agopian, Vatche G., Harlander-Locke, Michael P., Ruiz, Richard M., Klintmalm, Goran B., Senguttuvan, Srinath, Florman, Sander S., Haydel, Brandy, Hoteit, Maarouf, Levine, Matthew H., Lee, David D., Taner, C. Burcin, Verna, Elizabeth C., Halazun, Karim J., Abdelmessih, Rita, Tevar, Amit D., Humar, Abhinav, Aucejo, Federico, Chapman, William C., Vachharajani, Neeta, Nguyen, Mindie H., Melcher, Marc L., Nydam, Trevor L., Mobley, Constance, Ghobrial, R. Mark, Amundsen, Beth, Markmann, James F., Langnas, Alan N., Carney, Carol A., Berumen, Jennifer, Hemming, Alan W., Sudan, Debra L., Hong, Johnny C., Kim, Joohyun, Zimmerman, Michael A., Rana, Abbas, Kueht, Michael L., Jones, Christopher M., Fishbein, Thomas M., and Busuttil, Ronald W.

Published
2017
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26. Safety and Efficacy of Robotic vs Open Liver Resection for Hepatocellular Carcinoma.

Author

Di Benedetto, Fabrizio, Magistri, Paolo, Di Sandro, Stefano, Sposito, Carlo, Oberkofler, Christian, Brandon, Ellie, Samstein, Benjamin, Guidetti, Cristiano, Papageorgiou, Alexandros, Frassoni, Samuele, Bagnardi, Vincenzo, Clavien, Pierre-Alain, Citterio, Davide, Kato, Tomoaki, Petrowsky, Henrik, Halazun, Karim J., Mazzaferro, Vincenzo, and Robotic HPB Study Group

Published
2023
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27. Offer Acceptance Patterns for Liver Donors Aged 70 and Older

Author

Haugen, Christine E., primary, Bowring, Mary G., additional, Jackson, Kyle R., additional, Garonzik‐Wang, Jacqueline, additional, Massie, Allan B., additional, Chiang, Teresa Po‐Yu, additional, Philosophe, Benjamin, additional, Segev, Dorry L., additional, and Halazun, Karim J., additional

Published
2021
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28. Evaluation of the Intention-to-Treat Benefit of Living Donation in Patients With Hepatocellular Carcinoma Awaiting a Liver Transplant

Author

Lai, Quirino, primary, Sapisochin, Gonzalo, additional, Gorgen, Andre, additional, Vitale, Alessandro, additional, Halazun, Karim J., additional, Iesari, Samuele, additional, Schaefer, Benedikt, additional, Bhangui, Prashant, additional, Mennini, Gianluca, additional, Wong, Tiffany C.L., additional, Uemoto, Shinji, additional, Lin, Chih-Che, additional, Mittler, Jens, additional, Ikegami, Toru, additional, Yang, Zhe, additional, Frigo, Anna Chiara, additional, Zheng, Shu-Sen, additional, Soejima, Yuji, additional, Hoppe-Lotichius, Maria, additional, Chen, Chao-Long, additional, Kaido, Toshimi, additional, Lo, Chung Mau, additional, Rossi, Massimo, additional, Soin, Arvinder Singh, additional, Finkenstedt, Armin, additional, Emond, Jean C., additional, Cillo, Umberto, additional, and Lerut, Jan Paul, additional

Published
2021
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29. Black Patients Have Unequal Access to Listing for Liver Transplantation in the United States

Author

Rosenblatt, Russell, primary, Wahid, Nabeel, additional, Halazun, Karim J., additional, Kaplan, Alyson, additional, Jesudian, Arun, additional, Lucero, Catherine, additional, Lee, Jihui, additional, Dove, Lorna, additional, Fox, Alyson, additional, Verna, Elizabeth, additional, Samstein, Benjamin, additional, Fortune, Brett E., additional, and Brown, Robert S., additional

Published
2021
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30. Reply

Author

Halazun, Karim J., Patzer, Rachel E., Rana, Abbas A., Samstein, Benjamin, Brown, Robert S., Jr., and Emond, Jean C.

Published
2015
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35. Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma

Author

Halazun, Karim J., primary, Rosenblatt, Russell E., additional, Mehta, Neil, additional, Lai, Quirino, additional, Hajifathalian, Kaveh, additional, Gorgen, Andre, additional, Brar, Gagan, additional, Sasaki, Kazunari, additional, Doyle, Maria B. Majella, additional, Tabrizian, Parissa, additional, Agopian, Vatche G., additional, Najjar, Marc, additional, Ivanics, Tommy, additional, Samstein, Benjamin, additional, Brown, Robert S., additional, Emond, Jean C., additional, Yao, Francis, additional, Lerut, Jan, additional, Rossi, Massimo, additional, Mennini, Gianluca, additional, Iesari, Samuele, additional, Finkenstedt, Armin, additional, Schaefer, Benedikt, additional, Mittler, Jans, additional, Hoppe-Lotichius, Maria, additional, Quintini, Cristiano, additional, Aucejo, Federico, additional, Chapman, William, additional, and Sapisochin, Gonzalo, additional

Published
2021
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36. Evaluation of the Intention-to-Treat Benefit of Living Donation in Patients With Hepatocellular Carcinoma Awaiting a Liver Transplant.

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Lai, Quirino, Sapisochin, Gonzalo, Gorgen, Andre, Vitale, Alessandro, Halazun, Karim J, Iesari, Samuele, Schaefer, Benedikt, Bhangui, Prashant, Mennini, Gianluca, Wong, Tiffany C L, Uemoto, Shinji, Lin, Chih-Che, Mittler, Jens, Ikegami, Toru, Yang, Zhe, Frigo, Anna Chiara, Zheng, Shu-Sen, Soejima, Yuji, Hoppe-Lotichius, Maria, Chen, Chao-Long, Kaido, Toshimi, Lo, Chung Mau, Rossi, Massimo, Soin, Arvinder Singh, Finkenstedt, Armin, Emond, Jean C, Cillo, Umberto, Lerut, Jan, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Lai, Quirino, Sapisochin, Gonzalo, Gorgen, Andre, Vitale, Alessandro, Halazun, Karim J, Iesari, Samuele, Schaefer, Benedikt, Bhangui, Prashant, Mennini, Gianluca, Wong, Tiffany C L, Uemoto, Shinji, Lin, Chih-Che, Mittler, Jens, Ikegami, Toru, Yang, Zhe, Frigo, Anna Chiara, Zheng, Shu-Sen, Soejima, Yuji, Hoppe-Lotichius, Maria, Chen, Chao-Long, Kaido, Toshimi, Lo, Chung Mau, Rossi, Massimo, Soin, Arvinder Singh, Finkenstedt, Armin, Emond, Jean C, Cillo, Umberto, and Lerut, Jan

Abstract

Living-donor liver transplant (LDLT) offers advantages over deceased-donor liver transplant (DDLT) of improved intention-to-treat outcomes and management of the shortage of deceased-donor allografts. However, conflicting data still exist on the outcomes of LDLT in patients with hepatocellular carcinoma (HCC). To investigate the potential survival benefit of an LDLT in patients with HCC from the time of waiting list inscription. This multicenter cohort study with an intention-to-treat design analyzed the data of patients aged 18 years or older who had an HCC diagnosis and were on a waiting list for a first transplant. Patients from 12 collaborative centers in Europe, Asia, and the US who were on a transplant waiting list between January 1, 2000, and December 31, 2017, composed the international cohort. The Toronto cohort comprised patients from 1 transplant center in Toronto, Ontario, Canada who were on a waiting list between January 1, 2000, and December 31, 2015. The international cohort centers performed either an LDLT or a DDLT, whereas the Toronto cohort center was selected for its capability to perform both LDLT and DDLT. The benefit of LDLT was tested in the 2 cohorts before and after undergoing an inverse probability of treatment weighting (IPTW) analysis. Data were analyzed from February 1 to May 31, 2020. Intention-to-treat death was defined as a patient death that occurred for any reason and was calculated from the time of waiting list inscription for liver transplant to the last follow-up date (December 31, 2019). Four multivariable Cox proportional hazards regression models for intention-to-treat death were created. A total of 3052 patients were analyzed in the international cohort, of whom 2447 were men (80.2%) and the median (IQR) age at first referral was 58 (53-63) years. The Toronto cohort comprised 906 patients, of whom 743 were men (82.0%) and the median (IQR) age at first referral was 59 (53-63) years. In all the settings, LDLT was an independent

Published
2021

40. Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria

Author

Kardashian, Ani, primary, Florman, Sander S., additional, Haydel, Brandy, additional, Ruiz, Richard M., additional, Klintmalm, Goran B., additional, Lee, David D., additional, Taner, C. Burcin, additional, Aucejo, Federico, additional, Tevar, Amit D., additional, Humar, Abhinav, additional, Verna, Elizabeth C., additional, Halazun, Karim J., additional, Chapman, William C., additional, Vachharajani, Neeta, additional, Hoteit, Maarouf, additional, Levine, Matthew H., additional, Nguyen, Mindie H., additional, Melcher, Marc L., additional, Langnas, Alan N., additional, Carney, Carol A., additional, Mobley, Constance, additional, Ghobrial, Mark, additional, Amundsen, Beth, additional, Markmann, James F., additional, Sudan, Debra L., additional, Jones, Christopher M., additional, Berumen, Jennifer, additional, Hemming, Alan W., additional, Hong, Johnny C., additional, Kim, Joohyun, additional, Zimmerman, Michael A., additional, Nydam, Trevor L., additional, Rana, Abbas, additional, Kueht, Michael L., additional, Fishbein, Thomas M., additional, Markovic, Daniela, additional, Busuttil, Ronald W., additional, and Agopian, Vatche G., additional

Published
2020
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45. An international multicenter study of protocols for liver transplantation during a pandemic: A case for quadripartite equipoise

Author

Chew, Claire Alexandra, primary, Iyer, Shridhar Ganpathi, additional, Kow, Alfred Wei Chieh, additional, Madhavan, Krishnakumar, additional, Wong, Andrea Sze Teng, additional, Halazun, Karim J., additional, Battula, Narendra, additional, Scalera, Irene, additional, Angelico, Roberta, additional, Farid, Shahid, additional, Buchholz, Bettina M., additional, Rotellar, Fernando, additional, Chan, Albert Chi-Yan, additional, Kim, Jong Man, additional, Wang, Chih-Chi, additional, Pitchaimuthu, Maheswaran, additional, Reddy, Mettu Srinivas, additional, Soin, Arvinder Singh, additional, Derosas, Carlos, additional, Imventarza, Oscar, additional, Isaac, John, additional, Muiesan, Paolo, additional, Mirza, Darius F., additional, and Bonney, Glenn Kunnath, additional

Published
2020
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49. No Gains in Long-term Survival After Liver Transplantation Over the Past Three Decades

Author

Rana, Abbas, primary, Ackah, Ruth L., additional, Webb, Gwilym J., additional, Halazun, Karim J., additional, Vierling, John M., additional, Liu, Hao, additional, Wu, Meng-Fen, additional, Yoeli, Dor, additional, Kueht, Michael, additional, Mindikoglu, Ayse L., additional, Sussman, Norman L., additional, Galván, Nhu T., additional, Cotton, Ronald T., additional, O’Mahony, Christine A., additional, and Goss, John A., additional

Published
2019
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