Author: "Hakim K" - Searchworks@Jio Institute Digital Library Search Results

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1. Large Interferometer For Exoplanets (LIFE): IX. Assessing the Impact of Clouds on Atmospheric Retrievals at Mid-Infrared Wavelengths with a Venus-Twin Exoplanet

Author: Konrad, B. S., Alei, E., Quanz, S. P., Mollière, P., Angerhausen, D., Fortney, J. J., Hakim, K., Jordan, S., Kitzmann, D., Rugheimer, S., Shorttle, O., Wordsworth, R., and Collaboration, the LIFE
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Large Interferometer For Exoplanets (LIFE) initiative aims to develop a space based mid-infrared (MIR) nulling interferometer to measure the thermal emission spectra of temperate terrestrial exoplanets. We investigate how well LIFE could characterize a cloudy Venus-twin exoplanet to: (1) test our retrieval routine on a realistic non-Earth-like MIR spectrum of a known planet, (2) investigate how clouds impact retrievals, (3) refine the LIFE requirements derived in previous Earth-centered studies. We run retrievals for simulated LIFE observations of a Venus-twin exoplanet orbiting a Sun-like star located 10 pc from the observer. By assuming different models (cloudy and cloud-free) we analyze the performance as a function of the quality of the LIFE observation. This allows us to determine how well atmosphere and clouds are characterizable depending on the quality of the spectrum. Our study shows that the current minimal resolution ($R=50$) and signal-to-noise ($S/N=10$ at $11.2\mu$m) requirements for LIFE suffice to characterize the structure and composition of a Venus-like atmosphere above the cloud deck if an adequate model is chosen. However, we cannot infer cloud properties. The accuracy of the retrieved planet radius ($R_{pl}$), equilibrium temperature ($T_{eq}$), and Bond albedo ($A_B$) depend on the choice of model. Generally, a cloud-free model performs best and thus the presence of clouds cannot be inferred. This model dependence of retrieval results emphasizes the importance of developing a community-wide best-practice for atmospheric retrieval studies. If we consider higher quality spectra (especially $S/N=20$), we can infer the presence of clouds and pose first constraints on their structure., Comment: Accepted for publication in A&A; Updates: LIFE-series number changed from 10 to 9, additional references added to the discussion, language editing; 15 pages (main text incl. 8 figures and 6 tables) + appendix; comments are welcome. This paper is part of a series on the LIFE telescope. Related series papers: arXiv:2101.07500, arXiv:2203.00471, arXiv:2112.02054, arXiv:2204.10041
Published: 2023
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2. The Use of Autologous Tissue for Chest Feminization in Gender-Affirming Surgery

Author: Morrison, Shane D., Massie, Jonathan P., Kneib, Cameron J., Massenburg, Benjamin B., Impastato, Katherine, Said, Hakim K., and Cederna, Paul S.
Published: 2020
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3. Investigating the expression of anti/pro-inflammatory cytokines in the pathogenesis and treatment of ulcerative colitis and its association with serum level of vitamin D

Author: Amjad Ahmadi, Rasoul Yousefimashouf, Asadollah Mohammadi, Bahram Nikkhoo, Leili Shokoohizadeh, Mohammadali Khan Mirzaei, Mohammad Yousef Alikhani, Farshad Sheikhesmaili, and Hakim Khodaei
Subjects: Ulcerative colitis, Cytokine, Vitamin D, Inflammation, Pathogenesis, Treatment, Medicine, Science
Abstract: Abstract Ulcerative colitis is an idiopathic gastrointestinal disease described by chronic inflammation of the digestive system. Cytokines may be responsible for immunopathogenesis, mucosal and tissue damage, and even treatment response. In addition to its role in calcium and phosphorus homeostasis and bone health, vitamin D is an immunomodulatory and anti-inflammatory agent. Understanding the role of cytokines may lead to improving the pathogenesis and treatment of this disease, therefore we aimed to investigate the relative gene expression of pro- and anti-inflammatory cytokines in biopsy samples taken from the affected area in the colon of ulcerative colitis patients and its association with serum vitamin D levels. A total of 47 ulcerative colitis patients were enrolled in this case-control study. The case group consisted of 23 patients with treatment-resistant ulcerative colitis, and the control group consisted of 24 ulcerative colitis patients responding to routine treatment. Serum vitamin D levels were measured by ELISA method. Real-time PCR was employed to quantify the relative expression of pro- and anti-inflammatory cytokines in colon biopsy samples from case and control groups. The pro-inflammatory cytokines included tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, IL-17 A, and IL-33, while the anti-inflammatory cytokines were IL-10, IL-35, and TGF-β. Data are showed as mean ± standard deviation (SD), and p values 0.05). However, the gene expression levels of the principal pro-inflammatory cytokines, including IL-6, IL-1β, and TNF-α, were elevated in treatment-resistant patients compared to patients who responded to treatments. No correlation was observed between serum vitamin D levels and the gene expression of pro- and anti-inflammatory cytokines (p > 0.05). The present study did not identify a statistically significant correlation between the expression of pro- or anti-inflammatory cytokines and treatment response. Therefore, routine treatments had no effect on the expression of these cytokines in treatment-resistant patients. Additionally, serum vitamin D levels were not related to the relative expression of pro- and anti-inflammatory cytokines in the affected area of the colon of these patients. Despite the need for further research on the protective and pathological roles of cytokines and vitamin D, regular screening and early and complementary treatment may be beneficial in reducing inflammatory symptoms in these patients.
Published: 2025
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4. Implantable Cook-Swartz Doppler probe versus Synovis Flow Coupler for the post-operative monitoring of free flap breast reconstruction

Author: Um, Grace T., Chang, Jeff, Louie, Otway, Colohan, Shannon M., Said, Hakim K., Neligan, Peter C., and Mathes, David W.
Published: 2014
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5. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016

Author: Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Creagh-Brown, B., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., de Lange, D. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., Peelen, L. M., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Christopher, K. B., Tang, Z., Qiu, C., Ouyang, B., Cai, C., Guan, X., Regueira, T., Cea, L., Carlos, S. Juan, Elisa, B., Puebla, C., Vargas, A., Poulsen, M. K., Thomsen, L. P., Kjærgaard, S., Rees, S. E., Karbing, D. S., Wollersheim, T., Frank, S., Müller, M. C., Carbon, N. M., Skrypnikov, V., Pickerodt, P. A., Falk, R., Mahlau, A., Weber-Carstens, S., Lee, A., Inglis, R., Morgan, R., Barker, G., Kamata, K., Abe, T., Saitoh, D., Tokuda, Y., Green, R. S., Butler, M. B., Erdogan, M., Hwa, H. Tae, Gil, L. Jae, Vaquero, R. Hernández, Rodriguez-Ruiz, E., Lago, A. Lopez, Allut, J. L. Garcia, Gestal, A. Estany, Gonzalez, M. A. Garcia, Thomas-Rüddel, D. O., Schwarzkopf, D., Fleischmann, C., Reinhart, K., Suwanpasu, S., Sattayasomboon, Y., Filho, N. M. Filgueiras, Oliveira, J. C. A., Ballalai, C. S., De Lucia, C. V., Araponga, G. P., Veiga, L. N., Silva, C. S., Garrido, M. E., Ramos, B. B., Ricaldi, E. F., Gomes, S. S., Gemmell, L., MacKay, A., Wright, C., Docking, R. I., Doherty, P., Black, E., Stenhouse, P., Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Yatabe, T., Inoue, S., Sakaguchi, M., Egi, M., Abdelhamid, Y. Ali, Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Hokka, M., Egi, M., Mizobuchi, S., Kar, P., Plummer, M., Abdelhamid, Y. Ali, Giersch, E., Summers, M., Hatzinikolas, S., Heller, S., Chapman, M., Jones, K., Horowitz, M., Deane, A., Schweizer, R., Jacquet-Lagreze, M., Portran, P., Junot, S., Allaouchiche, B., Fellahi, J. L., Guerci, P., Ergin, B., Kapucu, A., Ince, C., Cioccari, L., Luethi, N., Crisman, M., Bellomo, R., Mårtensson, J., Shinotsuka, C. Righy, Fagnoul, D., Brasseur, A., Orbegozo, D., Vincent, J. L., Preiser, J. C., Preiser, J. C., Lheureux, O., Thooft, A., Brimioulle, S., Vincent, J. L., Iwasaka, H., Tahara, S., Nagamine, M., Ichigatani, A., Cabrera, A. Rugerio, Zepeda, E. Monares, Granillo, J. Franco, Sánchez, J. S. Aguirre, Montoya, A. A. Tanaka, Montenegro, A. Pedraza, Blanco, G. A. Gálvez, Robles, C. M. Coronado, Drolz, A., Horvatits, T., Roedl, K., Rutter, K., Kluge, S., Funk, G. C., Schneeweiss, B., Fuhrmann, V., Sabetian, G., Pooresmaeel, F., Zand, F., Ghaffaripour, S., Farbod, A., Tabei, H., Taheri, L., Anandanadesan, R., Metaxa, V., Teixeira, C., Pereira, S. M., Hernández-Marrero, P., Carvalho, A. S., Beckmann, M., Hartog, C. S., Schwarzkopf, D., Raadts, A., Robertsen, A., Førde, R., Skaga, N. O., Helseth, E., Honeybul, S., Ho, K., Lopez, P. Martinez, Gonzalez, M. Nieto, Ortega, P. Nuevo, Sola, E. Camara, Spasova, T., de la Torre-Prados, M. V., Kopecky, O., Rusinova, K., Waldauf, P., Cepeplikova, Z., Balik, M., Domínguez, J. Palamidessi, Almudevar, P. Matia, Carmona, S. Alcántara, Muñoz, J. J. Rubio, Castañeda, D. Palacios, Abellán, A. Naharro, Villamizar, P. Rodríguez, Ramos, J. Veganzones, Pérez, L. Pérez, Lucendo, A. Pérez, Ejarque, M. Camós, Estella, A., Camps, V. Lopez, Martín, M. C., Masnou, N., Barbosa, S., Varela, A., Palma, I., Cristina, L., Nunes, E., Pereira, I., Campello, G., Granja, C., Pande, R., Pandey, M., Varghese, S., Chanu, M., Van Dam, M. J., Ter Braak, E. W. M. T., Estella, A., Gracia, M., Viciana, R., Recuerda, M., Fontaiña, L. Perez, Tharmalingam, B., Kovari, F., Rose, L., Mcginlay, M., Amin, R., Burns, K., Connolly, B., Hart, N., Jouvet, P., Katz, S., Leasa, D., Mawdsley, C., Mcauley, D., Schultz, M., Blackwood, B., Denham, S., Worrall, R., Arshad, M., Isherwood, P., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Parpibaev, F., Sharipova, V., Blanco, G. A. Galvez, Guzman, C. I. Olvera, Sánchez, J. S. Aguirre, Granillo, J. Franco, Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Shafi, M., Tomar, D. S., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Cha, Y. 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C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA
Published: 2016
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6. Minimal invasive direct coronary artery bypass grafting via partial inferior sternotomy

Author: Hakim, K., Börgermann, J., and Gulielmos, Vassilios, editor
Published: 2004
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7. Calcinose striatopallidodentelée, hypoparathyroïdie et atteinte neurologique : étude de série

Author: El Otmani, H., Lahlou, I., Raji, L., Omari, S., Belmansour, Y., Moutaouakil, F., Boulaajaj, F.-Z., Mouden, M., Gam, I., Hakim, K., El Moutawakil, B., Rafai, M.-A., Fadel, H., and Slassi, I.
Published: 2013
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8. Clinical utility of CT angiography in DIEP breast reconstruction

Author: Keys, Kari A., Louie, Otway, Said, Hakim K., Neligan, Peter C., and Mathes, David W.
Published: 2013
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9. Nipple-Areola Complex Reconstruction

Author: Gougoutas, Alexander J., Said, Hakim K., Um, Grace, Chapin, Anne, and Mathes, David W.
Published: 2018
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10. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

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T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. 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L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
Published: 2016
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11. Application of Fibrin Glue in the Operative Treatment of Chylothorax

Author: Zerkowski, H.-R., Hakim, K., Rüter, F., Roth, G., Reidemeister, J. C., Schlag, Günther, editor, Wolner, Ernst, editor, and Eckersberger, Franz, editor
Published: 1995
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12. Contextualizing HIV testing experiences within the HIV prevention cascade: qualitative insights from refugee youth in Bidi Bidi refugee settlement, Uganda

Author: Carmen Helen Logie, Moses Okumu, Miranda Loutet, Madelaine Coelho, Alyssa McAlpine, Frannie MacKenzie, Simon Odong Lukone, Nelson Kisubi, Hakim Kalungi, Okello Jimmy Lukone, and Peter Kyambadde
Subjects: Refugee and internally displaced, HIV testing, HIV self-testing, Humanitarian, Uganda, Adolescent and youth, Public aspects of medicine, RA1-1270
Abstract: Abstract Background There remain key knowledge gaps regarding HIV testing needs and priorities among refugee youth in low and middle-income country (LMIC) humanitarian settings. The HIV prevention cascade framework focuses on three domains (motivation, access, effective use) central to prevention uptake, yet is understudied in relationship to HIV testing, particularly among refugee youth. Uganda is an exemplar context to explore refugee youth HIV testing needs and priorities as it hosts 1.5 million refugees and is Africa’s largest refugee hosting nation. In this study, we explored perceptions and experiences regarding HIV testing among refugee youth living in Bidi Bidi refugee settlement, Uganda. Methods We conducted a community-based research study in Bidi Bidi Refugee Settlement, one of the world’s largest refugee settlements with over 195,000 residents. This qualitative study involved four focus groups (2 with young women, 2 with young men) with refugee youth aged 16–24 living in Bidi Bidi refugee settlement. We applied thematic analysis informed by the HIV prevention cascade to understand domains of motivation, access, and effective use that emerged as salient for HIV testing engagement. Results Participants (n = 40; mean age: 20 years, standard deviation: 2.2) included refugee young women (n = 20) and young men (n = 20), of whom 88% had a lifetime HIV test and 58% had ever heard of HIV self-testing. Participant discussions described HIV testing motivation was influenced by dimensions of: HIV treatment and testing knowledge; risk perception; positive and negative consequences of use; and social norms regarding gender and age. Access to HIV testing was shaped by: limited availability; distance and language barriers; confidentiality concerns; and affordability. Effective use of and engagement with HIV testing was related to HIV serostatus knowledge self-efficacy and in/equitable partner dynamics. Conclusions Complex, multi-level factors shape motivation for, access to, and effective use of HIV testing among refugee youth in Bidi Bidi. Findings align with the HIV prevention cascade framework that helps to identify gaps to inform intervention development with youth in humanitarian settings. HIV testing approaches tailored for refugee youth in contexts such as Bidi Bidi can foster HIV prevention and treatment literacy, gender equity, gender-based violence prevention, and intersectional stigma reduction.
Published: 2024
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13. Herz- und Herz-Lungen-Transplantation: Indikationen, Chancen, Risiken

Author: Puehler, T., Ensminger, S., Schulz, U., Fuchs, U., Tigges-Limmer, K., Börgermann, J., Morshuis, M., Hakim, K., Oldenburg, O., Niedermeyer, J., Renner, A., and Gummert, J.
Published: 2014
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14. Carences en cobalamine : aspects neurologiques chez 27 patients

Author: El Otmani, H., Moutaouakil, F., Midafi, N., Moudden, M., Gam, I., Hakim, K., Fadel, H., Rafai, M.A., El Moutawakkil, B., and Slassi, I.
Published: 2009
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15. Binding of Polychlorinated Biphenyls to the Aryl Hydrocarbon Receptor

Author: Kafafi, Sherif A., Afeefy, Hussein Y., Said, Hakim K., and Kafafi, Abdel G.
Published: 1993
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16. The necropolis of Jebel Zebouzi (El Kef): integrated and multiscale archaeological analysis of protohistoric megalithic structures from Northern Tunisia

Author: Rocco Rotunno, Nabiha Aouadi, Amir Gharbi, Emanuele Cancellieri, Dana Cafieri, Martina Di Matteo, Hakim Kerkeni, Ileana Micarelli, and Savino di Lernia
Subjects: Protohistory, North Africa, Tunisia, Funerary archaeology, Megaliths, Remote Sensing, Field Survey & Excavations, Archaeology, CC1-960
Abstract: This paper focuses on the integrated and multiscale archaeological analysis of the necropolis of Jebel Zebouzi in El Kef, Northern Tunisia, shedding light on the complex and diverse megalithic structures that characterize the region. North Africa features a vast array of pre-Roman funerary monuments, ranging from monumental tombs influenced by Punic and Roman-Hellenistic examples to autochthonous rock-cut chamber tombs known as haouanet. The landscape is further enriched with bazinas, chouchet, tumuli, and dolmens, in some cases forming extensive necropolises. Despite their visibility, the understanding of these structures remains limited. Early assumptions regarding their dating were challenged, suggesting a Late Bronze Age origin. After two centuries of research, there remains a significant hiatus in knowledge regarding the spatial arrangement, funerary traditions, and chronology of these megalithic necropolises. To bridge this gap, the research project described in this paper has employed cutting-edge techniques such as drone imagery, photogrammetry for documentation during remote and on-foot surveys. Together with selected excavations and bioarchaeological analysis, the goal is to reconstruct some of the necropolis’ stratigraphical and spatial configuration, offering insights into horizontal and vertical social complexity and the utilization of space. The study addresses hence the phenomenon of reuse and modification of these ancient monuments over time, raising questions about cultural appropriation, memory, history, and the negotiation of cultural identity. This comprehensive approach aims to contribute to the understanding of North African pre-Roman funerary practices and the cultural dynamics that shaped these megalithic landscapes.
Published: 2024
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17. Reduktion von perioperativer Letalität und Morbidität in der Koronarchirurgie mit Clampless-off-pump-Technik: Propensity-Score-Analyse von 788 Patienten

Author: Börgermann, Jochen, Kuss, O., Hakim, K., Renner, A., Parsa, A., Aboud, A., Becker, T., Mirow, N., Zittermann, A., and Gummert, J.F.
Published: 2011
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18. Transonic Flow Field Analysis of a Minimum Nozzle Length Rocket Engine

Author: Omar ABADA, Hakim KBAB, and Sidali HAIF
Subjects: transonic flow field, line sonic, minimum length nozzle, high temperature, calorically imperfect gas, method of characteristics, numerical simulation, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract: The aim of this paper is to develop a profile of axisymmetric minimum length nozzle giving a uniform and parallel flow at the exit section. The study is done at high temperature, lower than the dissociation threshold of the molecules. The design is made by the method of characteristics (MOC). The variation of the specific heats with the temperature is considered. The numerical results have been validated with CFD simulation Ansys-Fluent software. The second part of this study is to calculate and analyze the transonic flow field of this supersonic nozzle. The computation of the flow field characteristics at the throat is thus essential to the nozzle developed thrust value and therefore to the aircraft or rocket it propels. An investigation was conducted to analyze the effects of parameters on the position of the sonic line. These parameters include stagnation temperature T0, radius of the nozzle, types of gases, and exit Mach number ME.
Published: 2024
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19. Myélopathies subaiguës révélatrices de sarcoïdose systémique

Author: Boulaajaj, F.Z., Rafai, M.A., El Otmani, H., El Moutawakkil, B., Hakim, K., Fadel, H., and Slassi, I.
Published: 2007
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20. Internationalization of the Humanities and Social Sciences: Realities and Challenges in Jordan

Author: Al Husban, Abdel Hakim K., primary and Na’Amneh, Mahmoud, additional
Published: 2010
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21. Structural Optimization processes for finding robust automotive lightweight concepts

Author: Schumacher, A., primary and Hakim, K., additional
Published: 2010
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22. Phase Doppler Anemometry Studies of Spray Freezing

Author: Al-Hakim, K., Wigley, G., and Stapley, A.G.F.
Published: 2006
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23. Accidents vasculaires cérébraux révélant un syndrome catastrophique des anti-phospholipides associé à une hépatite virale C

Author: Rafai, M.A., Fadel, H., Gam, I., Hakim, K., El Moutawakkil, B., Kissani, N., and Slassi, I.
Published: 2006
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24. Neuropathies périphériques sans cryoglobulinémie révélatrices de l’hépatite virale C: À propos de cinq observations

Author: Rafai, M.A., Gam, I., Fadel, H., Hakim, K., El Moutawakkil, B., Bendahmane, A., Kissani, N., Alaoui, R., Cherkaoui, A., and Slassi, I.
Published: 2006
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25. Design and Analysis Performance Solar Power Plant 15 kW By Maximizing Final Yield and Performance Ratio In Small-Medium Office

Author: Apribowo, C H B, primary, Nizam, M, additional, Pramono, S, additional, Maghfiroh, H, additional, and Hakim, K, additional
Published: 2021
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26. In Regard to Poppe et al

Author: Dyer, Brandon A., primary, Flanagan, Meghan R., additional, Said, Hakim K., additional, Kim, Janice, additional, Wang, Waylene, additional, and Fang, L. Christine, additional
Published: 2021
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27. Electocardiographic features in Ebstein's disease

Author: Antit, S., primary, Hakim, K., additional, Ouali, S., additional, Msaed, H., additional, and Ouarda, F., additional
Published: 2021
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28. Genetic characterization of Indonesian sorghum landraces (Sorghum bicolor (L.) Moench) for yield traits

Author: Reni Lestari, Mahat Magandhi, Arief Noor Rachmadiyanto, Kartika Ning Tyas, Enggal Primananda, Iin Pertiwi Amin Husaini, Frisca Damayanti, Rizmoon Nurul Zulkarnaen, Hendra Helmanto, Reza Ramdan Rivai, Hakim Kurniawan, and Masaru Kobayashi
Subjects: characteristic, genetic sources, indonesia, local sorghum, production, Agriculture (General), S1-972, Food processing and manufacture, TP368-456
Abstract: Sorghum (Sorghum bicolor (L.) Moench) is the fifth most produced cereal crop in the world. The use of sorghum is very diverse and most parts of the plant, including stem, leaves, grain, panicles, stem juice, and bagasse, can be utilized as human food, animal feed, and material for industry and bioenergy production. The collection of local sorghum genetic resources should be explored to identify potential gene sources for the development of superior varieties. This study was conducted to evaluate the production potential of 40 Indonesian sorghum accessions and to further identify potentially useful accessions. Five accessions belonging to cluster 3 had high biomass productivity, including Coley, Keler, Lao, Lokal Kaltim, and Super 1. In particular, Lokal Kaltim and Lao combined high biomass yield with grain yield. Accessions with high biomass has potential for use as feedstock for biomass energy production and forage.
Published: 2024
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29. In Regard to Poppe et al

Author: Waylene Wang, L. Christine Fang, Meghan R. Flanagan, Brandon A. Dyer, Hakim K. Said, and Janice N. Kim
Subjects: Cancer Research, Radiation, Oncology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Theology, business
Published: 2021
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30. Comparison of Outcomes in Immediate Implant-Based Breast Reconstruction Versus Mastectomy Alone

Author: Daniel Liu, Otway Louie, Peter C. Neligan, Hakim K. Said, Janelle D. Sousa, David W. Mathes, Kristine E. Calhoun, and Ravi F. Sood
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Original Articles, Immediate implant, Surgery, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Complication rate, Breast reconstruction, business, Mastectomy
Abstract: Immediate implant-based techniques are common practice in post-mastectomy breast reconstruction. Previous studies have shown an increased complication rate in the setting of immediate versus delayed, MD reconstruction. We aimed to quantify any additional risk in complications when implant-based immediate breast reconstruction (IBR) is performed versus mastectomy alone.We retrospectively reviewed all IBR cases and all mastectomies without reconstruction from 2007 to 2011. Patient characteristics, operative details, and complication rates were reviewed and analyzed.IBR was performed in 315 consecutive women; mastectomy alone was performed in 401 women. Patients undergoing mastectomy alone were more often older, diabetic, and more frequently underwent neoadjuvant chemotherapy or radiation. Overall complications were higher in the IBR group, most commonly reoperation and delayed wound healing. In a multivariate analysis, IBR, increasing age, body mass index, history of radiation therapy, smoking, and nipple-sparing mastectomy were independently associated with increased risk of complications. However, IBR was only independently associated with increased risk of major complications such as reoperation or readmission for intravenous antibiotics, not minor complications.Patients selected for IBR are inherently different than those undergoing mastectomy alone. After adjusting for these differences, the increased risk of complications seen in IBR is moderately increased over the risk of complications in mastectomy alone. The observed increased risk of major complications after IBR is largely due to the aggressive management of complications in the setting of a prosthetic implant. IBR is a safe reconstructive strategy with only a slightly increased risk over mastectomy alone.Les techniques de reconstruction mammaire immédiate par implant sont courantes après une mastectomie. Des études antérieures ont démontré un taux de complication plus élevé après une reconstruction immédiate qu’après une reconstruction tardive. Les auteurs ont cherché à quantifier le risque supplémentaire de complications après une reconstruction mammaire immédiate (RMI) par rapport à une mastectomie effectuée seule.Les auteurs ont procédé à une analyse rétrospective de toutes les RMI et de toutes les mastectomies sans reconstruction effectuées entre 2007 et 2011. Ils ont étudié et analysé les caractéristiques de patientes, les détails des opérations et le taux de complications.Selon l’analyse, 315 femmes consécutives ont subi une RMI et 401 femmes, une mastectomie seule. Les patientes qui avaient subi une mastectomie seule étaient souvent plus âgées, diabétiques et soumises à une chimiothérapie néoadjuvante ou à une radiothérapie. Les complications globales étaient plus élevées dans le groupe ayant subi une RMI, surtout à cause d’une réopération et d’une guérison plus lente des plaies. D’après une analyse multivariée, la RMI, le vieillissement, l’indice de masse corporelle, des antécédents de radiothérapiele tabagisme et une mastectomie épargnant le mamelon présentaient une corrélation indépendante avec un risque accru de complications. La RMI présentait seulement une corrélation indépendante avec un risque accru de complications majeures comme une réopération ou une réhospitalisation visant à administrer des antibiotiques par voie intraveineuse, et non de complications mineures.Les patientes sélectionnées pour la RMI sont foncièrement différentes de celles qui subissent une mastectomie seule. Après rajustement pour tenir compte de ces différences, le risque de complications observé après une RMI est légèrement plus élevé que celui qui s’associe à une mastectomie seule. Le risque accru de complications majeures observé après une RMI est largement attribuable à la prise en charge énergique des complications après un implant prothétique. La RMI est une stratégie de reconstruction sécuritaire dont le risque est seulement un peu plus élevé que la mastectomie seule.
Published: 2017
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31. The Use of Autologous Tissue for Chest Feminization in Gender-Affirming Surgery

Author: Shane D. Morrison, Paul S. Cederna, Hakim K. Said, Katherine A. Impastato, Cameron J. Kneib, Benjamin B. Massenburg, and Jonathan P. Massie
Subjects: Thorax, Male, medicine.medical_specialty, Feminization (biology), Mammaplasty, Treatment outcome, MEDLINE, Subcutaneous Fat, Autologous tissue, Transgender Persons, Transplantation, Autologous, Surgical Flaps, medicine, Sex Reassignment Surgery, Humans, Sex Characteristics, business.industry, Surgery, Transplantation, Treatment Outcome, Female, Transgender Person, business, Sex characteristics
Published: 2019

32. Increased cardiac endothelial nitric oxide synthase expression in patients taking angiotensin-converting enzyme inhibitor therapy

Author: Morawietz, H., Rohrbach, S., Rueckschloss, U., Schellenberger, E., Hakim, K., Zerkowski, H.-R., Kojda, G., Darmer, D., and Holtz, J.
Published: 2006

33. Transdermal Sustained-Delivery Oxygen Improves Epithelial Healing in a Rabbit Ear Wound Model

Author: Said, Hakim K., Hijjawi, John, Roy, Nakshatra, Mogford, Jon, and Mustoe, Thomas
Published: 2005

34. Dendritic Cell Differentiation and Maturation in Embryonic Rat Liver: Immunohistochemistry and Electron Microscopy with Reference to Dendritic Cell Contacts

Author: El-Nefiawy, N., Abdel-Hakim, K., Kanayama, N., and Terao, T.
Published: 2005
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35. The future of wound healing: Pursuing surgical models in transgenic and knockout mice

Author: Reid, Russell R., Said, Hakim K., Mogford, Jon E., and Mustoe, Thomas A.
Published: 2004
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36. Comparison of Synthetic and Biologic Mesh in Ventral Hernia Repair Using Components Separation Technique

Author: David W. Mathes, E. Patchen Dellinger, Brinkley K. Sandvall, Otway Louie, Hakim K. Said, Peter C. Neligan, and Daniel W. Suver
Subjects: Adult, Male, medicine.medical_treatment, 030230 surgery, Suture closure, Domain (software engineering), Abdominal wall, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Humans, Medicine, Herniorrhaphy, Aged, Retrospective Studies, business.industry, Ventral hernia repair, Middle Aged, Surgical Mesh, Hernia repair, Hernia, Ventral, Component separation, Logistic Models, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Multivariate Analysis, Female, Surgery, business, Follow-Up Studies, Biomedical engineering
Abstract: Ventral hernia repair (VHR) for large abdominal wall defects is challenging. Prior research established that the use of mesh is superior to suture closure alone and that component separation is an effective technique to combat loss of abdominal domain. Studies comparing component separation technique (CST) outcomes utilizing synthetic versus biologic mesh are limited. A retrospective review was conducted of 72 consecutive patients who underwent VHR with CST between 2006 and 2010 at our institution. Surgeon preference and the presence of contamination guided whether synthetic mesh (27 patients) or biologic mesh (45 patients) was used. Mean follow-up interval for all comers was 13.9 months and similar in both groups (P0.05). Degree of contamination and severity of premorbid medical conditions were significantly higher in the biologic mesh group, as reflected in the higher Ventral Hernia Working Group (VHWG) score (2.04 versus 2.86). Clinical outcomes, as measured by both minor and major complication rates and recurrence rates, were not significantly different. Minor complication rates were 26% in the synthetic group and 37% in the biologic group and major complication rates 15% in the synthetic group and 22% in the biologic group. There was 1 recurrence (4%) in the synthetic mesh group versus 5 (11%) in the biologic mesh group. Multivariable analysis for major complications revealed no significant difference for either synthetic or biologic mesh while controlling for other variables. Subset analysis of uncontaminated cases revealed recurrence rates of 4% in the synthetic mesh group and 6% in the biologic mesh group. VHR using CST and either synthetic mesh or biologic mesh resulted in low recurrence rates with similar overall complication profiles, despite the higher average VHWG grading score in the biologic mesh group. Our results support the VHWG recommendation for biologic mesh utilization in higher VHWG grade patients. In VHWG grade 2 patients, our clinical outcomes were similar, supporting the use of either type of mesh.
Published: 2016
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37. 17 - Perineal reconstruction

Author: Said, Hakim K. and Louie, Otway
Published: 2018
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38. Nipple-Areola Complex Reconstruction

Author: Anne Chapin, Hakim K. Said, Alexander J. Gougoutas, Grace Um, and David W. Mathes
Subjects: medicine.medical_specialty, Tattooing, business.industry, Nipple areola complex, medicine.medical_treatment, Mammaplasty, Local flap, Skin Transplantation, 030230 surgery, Surgical Flaps, Surgery, body regions, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Nipples, Humans, Medicine, Female, business
Abstract: After studying this article, the participant should be able to: 1. Understand how to determine nipple-areola complex positioning on the reconstructed breast. 2. Understand the multitude of local flap and distant graft options for nipple-areola complex reconstruction. 3. Draw at least three fundamental nipple-areola complex reconstruction patterns. 4. Understand the forces that are responsible for flattening of the reconstructed papule. 5. Understand the current techniques used in secondary nipple-areola complex reconstructions.Nipple-areola complex reconstruction and tattooing represent the final two stages of breast reconstruction. Nipple-areola complex reconstruction is typically accomplished with the use of local flaps, local flaps with augmentation grafts, or a combination thereof. Regardless of the technique used, however, all nipple-areola complex reconstructions lose a degree of projection over time. Options for secondary reconstruction include the use of local tissue flaps alone or in combination with acellular biological matrices.
Published: 2018

39. P1004Diagnosis and management of fetal cardiac arrhythmias: about 100 cases

Author: Messaoudi, Y, primary, Msaad, H, additional, Hakim, K, additional, and Ouarda, F, additional
Published: 2019
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40. Angiotensin-converting enzyme inhibitor therapy prevents upregulation of endothelin-converting enzyme-1 in failing human myocardium

Author: Morawietz, H, Goettsch, W, Szibor, M, Barton, M, Shaw, S, Hakim, K, Zerkowski, H.-R, and Holtz, J
Published: 2002
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41. Kabardian and Karachay-Balkar aristocrats' children in the Dmitryevskiy semisquadron of military cantonists in the 1830s

Author: Muslim I. Barazbiev, Albek Ch. Abazov, and Hakim K. Gegraev
Subjects: medicine.medical_specialty, Referral, business.industry, Family medicine, Medicine, Resistance (psychoanalysis), Advertising, business
Abstract: This article analyzes the reasons for the referral of children of Kabardian and Karachay-Balkar aristocrats to the Dmitryevskiy semisquadron of comissioned cantonists.
Published: 2017
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42. Altitude-compensating axisymmetric supersonic nozzle design and flow analysis

Author: Sidali HAIF, Hakim KBAB, and Amina BENKHEDDA
Subjects: e-d nozzle, dual bell nozzle, ansys-fluent, method of characteristics (moc), fortran, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract: Altitude-adapted nozzles are designed to facilitate flow adaptation during rocket ascent in the atmosphere, without requiring mechanical activation. As a consequence, the performance of the nozzle is significantly improved. The aim of this study is to develop a new profile of axisymmetric supersonic nozzles adapted at altitude (Dual Bell Nozzle with Central Body), which is characterized by an E-D nozzle as a basic profile. The performances obtained for this nozzle (E-D Nozzle) are then compared to those of a Plug nozzle. The E-D nozzle shows significant performance advantages over the Plug nozzle, including a 13.02% increase in thrust, knowing that the length of the E-D nozzle is half that of the Plug nozzle under the same design conditions. Finally, viscous calculations using the k-ω SST turbulence model were conducted to compare the performance of the dual bell nozzle with central body (DBNCB) and the E-D nozzle with the same cross-sectional ratio, and to assess the impact of nozzle pressure ratio (NPR) variations on the operation mode of the DBNCB. The results obtained show that the DBNCB offers the best performance in most phases of flight.
Published: 2023
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43. Comparison of Outcomes Using AlloDerm Versus FlexHD for Implant-Based Breast Reconstruction

Author: Daniel Z. Liu, David W. Mathes, Hakim K. Said, Peter C. Neligan, and Otway Louie
Subjects: Acellular Dermis, medicine.medical_specialty, Breast Implants, Mammaplasty, medicine.medical_treatment, Tissue Expansion, Treatment outcome, Comorbidity, Risk Factors, Diabetes Mellitus, Humans, Surgical Wound Infection, Medicine, Obesity, Breast Implantation, Mastectomy, Retrospective Studies, Wound Healing, business.industry, Incidence, Smoking, Follow up studies, Tissue Expansion Devices, Cellulitis, Skin Transplantation, Middle Aged, Prosthesis Failure, Surgery, Equipment Failure Analysis, Treatment Outcome, Smoking epidemiology, Multivariate Analysis, Female, Collagen, Implant, business, Breast reconstruction, Tissue expansion, Follow-Up Studies
Abstract: Prosthetic reconstruction using human acellular dermis (ADM) is a common practice in breast reconstruction. AlloDerm and FlexHD are two different forms of ADM, each with unique characteristics. No studies have directly compared the postoperative complications of these 2 products.The outcomes of 547 consecutive implant-based breast reconstructions were reviewed.Reconstruction was performed in 382 consecutive women (547 total breasts), employing mostly immediate reconstruction (81%). Mean follow-up was 6.4 months. Among immediate reconstructions, 165 used AlloDerm and 97 used FlexHD. Complications were similar by univariate analysis. In multivariate analysis, smoking and higher initial implant fill were risk factors for delayed healing. The use of FlexHD, single-stage reconstruction, and smoking were independent risk factors for implant loss.There is no significant difference in the complication rates between AlloDerm and FlexHD in immediate breast reconstruction. Multivariate analysis suggests that FlexHD may be a risk factor for implant loss.
Published: 2014
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44. Intracerebral hemorrhage in ICU: is it worth treating?

Author: Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, Kingma, W, Navis, G, Boerma, E, Rulisek, J, Balik, M, Zacharov, S, Kim, H, Jeon, S, Namgung, H, Lee, E, Cho, Y, Lee, Y, Huang, A, Cioccari, L, Luethi, N, Mårtensson, J, Bellomo, R, Forsberg, M, Edman, G, Höjer, J, Forsberg, S, Freile, M, Hidalgo, F, Molina, J, Lecumberri, R, Rosselló, A, Travieso, P, Leon, G, Sanchez, J, Frias, L, Rosello, D, Verdejo, J, Serrano, J, Winterwerp, D, van Galen, T, Vazin, A, Karimzade, I, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, B, Kureshi, N, Fenerty, L, Thibault Halman, G, Erdogan, M, Walling, S, Green, R, Clarke, D, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Politi, E, Kostopanagiotou, G, Crewdson, K, Rehn, M, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Baker, C, Mansfield, L, Stafford, V, Wade, C, Watson, G, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Furneval, J, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Baudouin, S, Ramírez, C, Escalada, S, Viera, M, Santana, M, Balcázar, L, 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Subjects: intracerebral haemorrhage in intensive care
Published: 2016

45. Management of the Repeatedly Failed Cranioplasty Following Large Postdecompressive Craniectomy: Establishing the Efficacy of Staged Free Latissimus Dorsi Transfer/Tissue Expansion/Custom Polyetheretherketone Implant Reconstruction

Author: Craig B. Birgfeld, Gerhard S. Mundinger, Richard G. Ellenbogen, Kerry Latham, Hakim K. Said, Richard A. Hopper, Jeffery Friedrich, and Otway Louie
Subjects: Adult, Male, medicine.medical_specialty, Decompressive Craniectomy, Polymers, medicine.medical_treatment, Tissue Expansion, Dehiscence, Esthetics, Dental, Free Tissue Flaps, Polyethylene Glycols, 03 medical and health sciences, Benzophenones, 0302 clinical medicine, Postoperative Complications, Surgical Wound Dehiscence, medicine, Humans, Craniotomy, Aged, Retrospective Studies, Scalp, business.industry, Skull, Soft tissue, General Medicine, Prostheses and Implants, Ketones, Middle Aged, Cranioplasty, Surgery, Decompressive Craniectomies, medicine.anatomical_structure, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Implant reconstruction, Superficial Back Muscles, Computer-Aided Design, Female, business, 030217 neurology & neurosurgery, Tissue expansion
Abstract: BACKGROUND Postdecompressive craniotomy defect management following failed prior cranioplastyis challenging. The authors describe a staged technique utilizing free muscle transfer, tissue expansion, and custom polyetheretherketone (PEEK) implants for the management of previously failed cranioplasty sites in patients with complicating local factors. METHODS Consecutive patients with previously failed cranioplasties following large decompressive craniectomies underwent reconstruction of skull and soft tissue defects with staged free latissimus muscle transfer, tissue expansion, and placement of custom computer-aided design and modeling PEEK implants with a 'temporalis-plus' modification to minimize temporal hollowing. Implants were placed in a vascularized pocket at the third stage by elevating a plane between the previously transferred latissimus superficial fascia (left on the skin) and muscle (left on the dura/bone). Patients were evaluated postoperatively for cranioplasty durability, aesthetic outcome, and complications. RESULTS Six patients with an average of 1.6 previously failed cranioplasties underwent this staged technique. Average age was 33 years. Average defect size was 139 cm. Average time to procedure series completion was 14.9 months. There were no flap failures. One patient had early postoperative incisional dehiscence following PEEK implant placement that was managed by immediate scalp flap readvancement. At 21.9 month average follow-up, there were no cranioplasty failures. Three patients (50%) underwent 4 subsequent refining outpatient procedures. All patients achieved complete coverage of their craniectomy defect site with hear-bearing skin, acceptable head shape, and normalized head contour. CONCLUSIONS The described technique resulted in aesthetic, durable craniectomy defect reconstruction with retention of native hear-bearing scalp skin in a challenging patient population.
Published: 2016

46. ESICM LIVES 2016: part two

Author: Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. 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F., Nottin, S., Walther, G., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Monfort, B., Stazi, E., Roig, A. Lozano, Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Arunkumar, A. S., Lozano, A., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. Vieira, Amarante, G., Skorko, A., Sanders, S., Aron, J., Kroll, R. J., Redfearn, C., Krishnan, P., Khalil, J. E., Kongpolprom, N., Gulia, V., Lourenço, E., Duro, C., Baptista, G., Alves, A., Arminda, B., Rodrigues, M., Hayward, J., Baldwin, F., Gray, R., Katinakis, P. A., Stijf, M., Ten Kleij, M., Jansen-Frederiks, M., Broek, R., de Bruijne, M., Spronk, P. E., Sinha, K., Luney, M., Palmer, K., Keating, L., Abu-Habsa, M., Bahl, R., Baskaralingam, N., Ahmad, A., Kanapeckaite, L., Bhatti, P., Glace, S., Jeyabraba, S., Lewis, H. F., Kostopoulos, A., Raja, M., West, A., Ely, A., Turkoglu, L. M., Zolfaghari, P., Baptista, J. P., Marques, M. P., Martins, P., Pimentel, J., Su, Y. C., Villacres, S., Stone, M. E., Parsikia, A., Medar, S., O’Dea, K. P., Porter, J., Tirlapur, N., Jonathan, J. M., Singh, S., Takata, M., McWhirter, E., Lyon, R., Hariz, M. L., Azmi, E., Alkhan, J., Movsisyan, V., Petrikov, S., Marutyan, Z., Aliev, I., Evdokimov, A., Antonucci, E., Merz, T., Hartmann, C., Calzia, E., Radermacher, P., Nußbaum, B., Huber-Lang, M., Gröger, M., Svoren-Jabalera, E., Davenport, E. E., Humburg, P., Knight, J., Hinds, C. J., Jun, I. J., Kim, W. J., Lee, E. H., Besch, G., Perrotti, A., Puyraveau, M., Baltres, M., Samain, E., Chocron, S., Pili-Floury, S., Plata-Menchaca, E. P., Sabater-Riera, J., Estruch, M., Boza, E., Toscana-Fernández, J., Bruguera-Pellicer, E., Ordoñez-Llanos, J., Pérez-Fernández, X. L., Cavaleiro, P., Tralhão, A., Arrigo, M., Lopes, J.-P., Lebrun, M., Cholley, B., PerezVela, J. L., MarinMateos, H., Rivera, J. J. Jimenez, Llorente, M. A. Alcala, De Marcos, B. Gonzalez, Fernandez, F. J. Gonzalez, Laborda, C. Garcia, Zamora, D. Fernandez, Delgado, J. C. 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A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Welsh, S. P., Guerra, E., Zerpa, M. C. l., Zechner, F., Berdaguer, F., Risso-Vazquez, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Morales, M. A. Lopez, Pires, T., and Azevedo, L. C. P.
Subjects: Meeting Abstracts
Abstract: Introduction In addition to systemic hemodynamics, the management\ud of neurocritically ill patients is often informed by neuromonitoring. In\ud the absence of high-level evidence clinicians are often guided by personal\ud and local expertise. Little is known about practices as they pertain\ud to the use of such monitoring in patients with acute brain injury (ABI).\ud Objectives To investigate practices in bedside monitoring for ABI patients.\ud Particularly interested in differences among “neurointensivists”\ud (NIs; defined here as intensivists whose clinical practice is comprised\ud > 1/3 by neurocritical care) and other intensivists (OIs). Also, to\ud explore patterns specific to traumatic brain injury (TBI) and subarachnoid\ud hemorrhage (SAH), as well as preferences and availability of\ud particular technologies/devices.\ud Methods Electronic survey of 22 items including two case-based scenarios;\ud endorsed by SCCM (9,000 recipients) and ESICM (on-line\ud newsletter) in 2013. A sample size of 370 was calculated based on a\ud population of 10,000 physician members, a 5 % margin error, and\ud 95 % confidence interval. We summarized results using descriptive\ud statistics (proportions with 95 % confidence intervals). A chi-square\ud test was used to compare proportions of responses between NIs and\ud OIs with a significance p < 0.05.\ud Results There were 655 responders (66 % completion rate); 422(65 %)\ud were classified as OIs and 226(35 %) as NIs. More NIs follow\ud hemodynamic protocols for neurocritically-ill patients (56 % vs. 43 %, p\ud 0.001), in TBI (44.5 % vs. 33.3 %, p 0.007), and in SAH (38.1 % vs. 21.3 %,\ud p < 000.1). For delayed cerebral ischemia (DCI), more NIs target cardiac\ud index (CI) (35 % vs. 21 %, p 0.0001), and fluid responsiveness (62 % vs.\ud 53 %, p 0.03), use more bedside ultrasound (BUS) (42 % vs. 29 %, p\ud 0.005) and arterial waveform analysis (40 % vs. 29 %, p 0.02). For DCI\ud neuromonitoring, NIs use more angiography (57 % vs. 43 %, p 0.004),\ud TCD (46 % vs. 38 %, p 0.0001), and CTP (32 % vs.16 %, p 0.0001). For\ud CPP optimization in TBI, NIs use more arterial waveform analysis (45 %\ud vs. 35 %, p 0.019), and BUS (37 % vs. 27.7 %, p 0.023), while more OIs\ud monitor mixed venous oxygen saturation (54.1 % vs. 45 %, p 0.045). For\ud TBI neuromonitoring, NIs use more PbtO2 (28 % vs. 10 %, p 0.0001). In\ud the case scenario of raised ICP/low PbtO2, most employ analgosedation\ud (47 %) and osmotherapy (38 %). Fewer make use of preserved pressure\ud reactivity, particularly OIs (vasopressor use 23 % vs. 34 %, p 0.014).\ud Conclusions There is large heterogeneity in the use of monitoring protocols,\ud variables, and technologies/devices. “Neurointensivists” not only\ud employ more neuromonitoring but also more hemodynamic monitoring\ud in patients with acute brain injury. ICP/CPP remain the most commonly\ud followed neuro-variables in TBI patients, with low use of other\ud brain-physiology parameters, sugg
Published: 2016

47. PRIMITIVE AND CURRENT CULTIVARS OF RICE IN ASSAM–A RICH SOURCE OF VALUABLE GENES

Author: SHARMA, S. D., VELLANKI, J. M. R., HAKIM, K. L., and SINGH, R. K.
Published: 1971

48. An unusual outcome of a right atrium wall abscess in an infant. A case report

Author: Jebri, F., Msaaed, H., Melki, B., Oueslati, C., Hakim, K., and Boussada, R.
Published: 2015
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49. 17 - Reconstrução perineal

Author: Said, Hakim K. and Louie, Otway
Published: 2015
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50. 023 HRE-Luciferase Transfection Quantifies Tissue Level Ischemia in a Rabbit Ear Wound Model

Author: Nakshatra K. Roy, Hakim K. Said, J.Y. Kim, and Thomas A. Mustoe
Subjects: Pathology, medicine.medical_specialty, Ischemia, Dermatology, Transfection, Biology, Hypoxia (medical), medicine.disease, Oxygen tension, Andrology, medicine.anatomical_structure, Hypoxia-inducible factors, medicine, Surgery, Luciferase, medicine.symptom, Wound healing, Caudal artery
Abstract: The Hypoxia Inducible Factor (HIF) system has been characterized as the principal tissue level response to hypoxia. Posttranslational regulation of HIF-1alpha has been reported to act though a Hypoxia Responsive Element (HRE) promoter region on a range of hypoxia-induced genes. A plasmid was constructed consisting of a fivefold HRE repeat conjugated to a luciferase gene, used as a marker for HRE activation. Plasmid HRE-luciferase was then transfected into a well-established ischemic rabbit ear wound healing model. Ischemia was induced using a variety of published models for interruption of arterial inflow and compared with a nonischemic control. Central artery, caudal artery and rostrocaudal artery models were tested for induction of ischemia. Tissue specimens were harvested from the transfected areas and solubilized. Luminescence of each specimen was measured using a standard luminometer to quantify luciferase induction. To provide correlation on a regional level, tissue level oxygen tension was measured directly for each wound model. Profound and statistically significant differences were found in the induced luciferase production. Marked differences in the tissue hypoxia between the various ischemic wound healing models correlated in graded fashion with the ischemia induced on an anatomic basis. The least ischemic model showed no significant difference in hypoxia readings versus control. The intermediate model showed a significant fourfold greater ischemia signaling. The most ischemic model showed a highly significant 72-fold greater ischemic response compared to controls. The use of gene transfection is described as a sensitive and effective method for quantification of tissue hypoxia at a cellular level in ischemic wounds. Acknowledgments: This study was funded by the Wound Healing Research Laboratory.
Published: 2008
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