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2. Enhancing the quality of evidence, comparability, and reproducibility in ventriculoatrial shunt research for normal pressure hydrocephalus: A systematic review and VAS-NPH reporting guideline

Author

Yuri Ferreira, Marcio, Oliveira, Leonardo B., Porto Júnior, Silvio, Semione, Gabriel, Palavani, Lucca B., Batista, Savio, Pari Mitre, Lucas, Borges, Pedro G.L.B., Abrantes Barros, Emanuel, Andreão, Filipi, Porto Sousa, Marcelo, Gomez, Diego, Bertani, Raphael, and Hakim, Fernando

Published
2024
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4. Ventriculoatrial Shunt

Author

Usuga, Valentina, Mattar, Salvador M., Gomez Amarillo, Diego, Ramon, Juan Fernando, Hakim, Fernando, and Bradac, Ondrej, editor

Published
2023
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6. Proposal for a normal pressure hydrocephalus syndrome center of excellence

Author

Hakim, Fernando, Ramón, Juan Fernando, Gómez, Diego F., Ghotme, Kemel A., Mejía, Juan Armando, Jimenez, Enrique, González, Martina, Jaramillo-Velásquez, Daniel, Dominguez, Maria Teresa, Araque, Yesid, Cardenas, Maria Fernanda, Vallejo, Maria del Carmen, Soto, Hugo Alfredo, Espejo, Alfonso, Martinez, Carlos Fernando, Mayorga, Maria del Pilar, Hurtado, Cethinia, Cruz, Francy, Guacaneme, Francy, Ortega, Leidy Johana, Murcia, Liliana, Bermudez, Sonia, Useche, Juan Nicolas, Niño, Maria Claudia, Cohen, Darwin, Mora, Martha Cecilia, Castelblanco, Diana Maria, Soler, Sandra Janneth, Mejía, Etelvina, and Daza, Marcela

Published
2022
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8. High Grade Meningiomas: Current Therapy Based on Tumor Biology

Author

Esteban Garcia-Robledo, Juan, primary, Ordóñez-Reyes, Camila, additional, Ruiz-Patiño, Alejandro, additional, Muñoz, Álvaro, additional, Arrieta, Oscar, additional, Jiménez, Enrique, additional, Hakim, Fernando, additional, Gómez, Diego, additional, Fernando Ramón, Juan, additional, and F. Cardona, Andrés, additional

Published
2022
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12. Efficacy of osimertinib plus bevacizumab in glioblastoma patients with simultaneous EGFR amplification and EGFRvIII mutation

Author

Cardona, Andrés F., Jaramillo-Velásquez, Daniel, Ruiz-Patiño, Alejandro, Polo, Carolina, Jiménez, Enrique, Hakim, Fernando, Gómez, Diego, Ramón, Juan Fernando, Cifuentes, Hernando, Mejía, Juan Armando, Salguero, Fernando, Ordoñez, Camila, Muñoz, Álvaro, Bermúdez, Sonia, Useche, Nicolas, Pineda, Diego, Ricaurte, Luisa, Zatarain-Barrón, Zyanya Lucia, Rodríguez, July, Avila, Jenny, Rojas, Leonardo, Jaller, Elvira, Sotelo, Carolina, Garcia-Robledo, Juan Esteban, Santoyo, Nicolas, Rolfo, Christian, Rosell, Rafael, and Arrieta, Oscar

Published
2021
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16. The state of art of awake craniotomy in Latin American countries: a scoping review

Author

Figueredo, Luisa F., primary, Shelton, William J., additional, Tagle-Vega, Uriel, additional, Sanchez, Emiliano, additional, de Macedo Filho, Leonardo, additional, Salazar, Andres F., additional, Murguiondo-Pérez, Renata, additional, Fuentes, Santiago, additional, Marenco-Hillembrand, Lina, additional, Suarez-Meade, Paola, additional, Ordoñez-Rubiano, Edgar, additional, Gomez Amarillo, Diego, additional, Albuquerque, Lucas Alverne F., additional, de Amorim, Robson Luis Oliveira, additional, Vasquez, Carlos M., additional, Baldoncini, Matias, additional, Mejia, Juan Armando, additional, Niño, Claudia, additional, Ramon, Juan Fernando, additional, Hakim, Fernando, additional, Mendez-Rosito, Diego, additional, Navarro-Bonnet, Jorge, additional, Quiñones-Hinojosa, Alfredo, additional, and Almeida, Joao Paulo, additional

Published
2023
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17. Cognitive changes after tap test in patients with normal pressure hydrocephalus: a before-and-after study.

Author

Mayorga, Pilar, Hurtado, Cethinia, Gempeler, Andrés, Cruz-Sanabria, Francy, González, Martina, Jaramillo, Daniel, Mejía-Michelsen, Isabella, Ramón, Juan Fernando, Gomez-Amarillo, Diego Fernando, and Hakim, Fernando

Subjects
HYDROCEPHALUS, COGNITIVE testing, COGNITION, EXECUTIVE function, COGNITIVE ability
Abstract

Normal pressure hydrocephalus (NPH) leads to cognitive impairment (CI) as part of its triad of symptoms. Assessment of CI before and after a tap test can be used to inform diagnosis, differentiate NPH symptoms from alternative or concomitant causes of CI, and suggest the potential benefits of valve placement. The aims of this study are: to describe cognitive performance in patients with NPH diagnosis before and after a tap test, and to compare CI between patients with NPH meeting criteria for a dementia diagnosis (D +) and those without criteria for dementia (D−) at both baseline and after the tap-test. We performed a Before-and-after study evaluating clinical features and performance on cognitive tests (CERAD, ADAS-COG, SVF, PVF, ROCF and IFS). We included 76 NPH patients, with a median age of 81 years. 65 patients (87.8%) improved cognitive performance after tap test. ROCF (p = 0.018) and IFS (p < 0.001) scores significantly change after the tap test. Dementia was concomitant in 68.4% of patients. D + group showed higher proportion of patients with altered performance in IFS, PVF, SVF, and ROCF than D- group at baseline (p < 0.05). A significant improvement in SVF and IFS was observed exclusively in the D− group after tap test. Our results suggest that executive function and praxis are the cognitive domains more susceptible to improvement after a tap test in a 24-h interval in NPH patients. Moreover, the D− group showed a higher proportion of improvement after the tap test in executive function and verbal fluency test compared with the D + group. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Salomón Hakim, MD (1922–2011): A honeymoon with Neurosurgery.

Author

Jaramillo-Velásquez, Daniel, Hakim, Fernando, and Demetriades, Andreas K

Abstract

Salomón Hakim (1922–2011) was a Colombian neurosurgeon and brain scientist This biography examines the social and cultural background through which he emerged as an inquisitive and multi-dimensional surgeon-scientist, and his lifelong contributions to the specialty of neurosurgery. With empirical knowledge in applied medical physics, electronics, electricity and chemistry, he understood the paradoxical phenomenon of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. This ultimately led Hakim to describe in exquisite detail the physics of the cranial cavity and brain hydrodynamics. His name is intertwined with the identification of the entity of a syndrome which had not previously been addressed in the medical literature: Normal Pressure Hydrocephalus (Hakim's syndrome). Additionally, he designed and built various models of valved shunting devices to treat the condition (eg the Hakim programmable valve). Through his selflessness and cogent work, Hakim left a legacy and intellectual heritage that has allowed many colleagues worldwide to save thousands of lives who would be otherwise condemned to oblivion. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A novel approach to addressing intercavernous sinus bleeding: Preoperative onyx embolization in the endoscopic endonasal approach for craniopharyngioma resection.

Author

Gomez, Diego, Rairan, Luis Garcia, Mejia, Juan Andres, and Hakim, Fernando

Subjects
SKULL base, SKULL injuries, SURGICAL excision, CRANIOPHARYNGIOMA, WOMEN patients, HEMORRHAGE, ENDOSCOPIC surgery, CEREBRAL angiography
Abstract

Background: Hemorrhage originating from the intercavernous sinuses during transsphenoidal approaches for skull base injury is a common occurrence, but it can be easily controlled. However, in specific cases, it may necessitate suspending the surgery or result in hemodynamic instability. Case Description: We present the case of a 7-year-old female patient who underwent transsphenoidal endoscopic endonasal for craniopharyngioma resection. The patient's parents gave consent for the procedure. During the procedure, significant intraoperative bleeding occurred, which was necessary to stop the resection. After the surgery, cerebral angiography was performed, which identified a prominent anterior intercavernous venous sinus as the source of the bleeding. A successful embolization using onyx was performed, leading to a satisfactory postoperative recovery without any complications. The patient then underwent a second surgical intervention for the resection of the craniopharyngioma through an endoscopic endonasal transsphenoidal approach. This procedure achieved a complete resection of the lesion without complications, and the patient experienced an adequate postoperative recovery. Conclusion: The objective of this case is to describe a previously unreported technique involving onyx embolization for controlling prominent bleeding from the intercavernous sinus and as a presurgical embolization method to reduce the risk of bleeding during endoscopic endonasal surgery for resection of a craniopharyngioma. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Understanding the molecular profiling of diffuse gliomas classification: A brief overview

Author

Rubiano, Edgar G. Ordóñez, primary, Baldoncini, Matías, additional, Cómbita, Alba Lucía, additional, Payán-Gómez, César, additional, Gómez-Amarillo, Diego F., additional, Hakim, Fernando, additional, Figueredo, Luisa Fernanda, additional, Forlizzi, Valeria, additional, Rangel, Carlos Castillo, additional, Luzzi, Sabino, additional, Campero, Alvaro, additional, and Parra-Medina, Rafael, additional

Published
2023
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22. DICER1-associated central nervous system sarcoma: A comprehensive clinical and genomic characterization of case series of young adult patients

Author

Cardona, Andrés F, primary, Chamorro Ortiz, Diego Fernando, additional, Ruíz-Patiño, Alejandro, additional, Gomez, Diego, additional, Muñoz, Álvaro, additional, Ardila, Dora V, additional, Garcia-Robledo, Juan Esteban, additional, Ordóñez-Reyes, Camila, additional, Sussmann, Liliana, additional, Mosquera, Andrés, additional, Forero, Yency, additional, Rojas, Leonardo, additional, Hakim, Fernando, additional, Jimenez, Enrique, additional, Ramón, Juan Fernando, additional, Cifuentes, Hernando, additional, Pineda, Diego, additional, Mejía, Juan Armando, additional, Rodríguez, July, additional, Archila, Pilar, additional, Sotelo, Carolina, additional, Moreno-Pérez, Darwin A, additional, and Arrieta, Oscar, additional

Published
2023
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23. Efficacy and safety of Levetiracetam vs. other antiepileptic drugs in Hispanic patients with glioblastoma

Author

Cardona, Andrés F., Rojas, Leonardo, Wills, Beatriz, Bernal, Laura, Ruiz-Patiño, Alejandro, Arrieta, Oscar, Hakim, Enrique Jiménez, Hakim, Fernando, Mejía, Juan Armando, Useche, Nicolás, Bermúdez, Sonia, Carranza, Hernán, Vargas, Carlos, Otero, Jorge, Mayor, Luis Carlos, Ortíz, León Darío, Franco, Sandra, Ortíz, Carlos, Gil-Gil, Miguel, Balaña, Carmen, and Zatarain-Barrón, Zyanya Lucia

Published
2017
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26. Importancia pronóstica de las mutaciones del gen promotor de la transcriptasa inversa de la telomerasa en los meningiomas de alto grado

Author

Cañas, Alejandro, primary, Jiménez, Enrique, additional, Hakim, Fernando, additional, Mejía, Juan Armando, additional, Ramón, Juan Fernando, additional, Gómez, Diego, additional, Jaramillo-Velásquez, Daniel, additional, Bermúdez, Sonia, additional, Useche, Nicolás, additional, Pineda, Diego, additional, Cifuentes, Hernando, additional, Becerra, Antonio, additional, Muñoz, Álvaro, additional, Santoyo, Nicolás, additional, Ruíz-Patiño, Alejandro, additional, Sotelo, Carolina, additional, Archila, Pilar, additional, Rodríguez, July, additional, Ávila, Jenny, additional, Ordoñez-Reyes, Camila, additional, García-Robledo, Juan Esteban, additional, Ricaurte, Luisa, additional, Rojas, Leonardo, additional, Feo, Oscar, additional, Burgos, Remberto, additional, Ramírez, Carlos, additional, Arrieta, Oscar, additional, Zatarain-Barrón, Lucía, additional, Vargas, Carlos, additional, Carranza, Hernán, additional, Otero, Jorge, additional, and Cardona, Andrés F., additional

Published
2022
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27. Prognostic significance of telomerase reverse transcriptase promoter gen mutations in high grade meningiomas

Author

Cañas , Alejandro, Jiménez , Enrique, Hakim , Fernando, Mejía , Juan Armando, Ramón , Juan Fernando, Gómez , Diego, Jaramillo-Velásquez , Daniel, Bermúdez , Sonia, Useche , Nicolás, Pineda , Diego, Cifuentes , Hernando, Becerra, Antonio, Muñoz , Álvaro, Santoyo , Nicolás, Ruíz-Patiño , Alejandro, Sotelo , Carolina, Archila , Pilar, Rodríguez , July, Ávila , Jenny, Ordoñez-Reyes, Camila, García-Robledo , Juan Esteban, Ricaurte , Luisa, Rojas , Leonardo, Feo , Oscar, Burgos , Remberto, Ramírez , Carlos, Arrieta , Oscar, Zatarain-Barrón , Lucía, Vargas , Carlos, Carranza , Hernán, Otero , Jorge, Cardona , Andrés F., Cañas , Alejandro, Jiménez , Enrique, Hakim , Fernando, Mejía , Juan Armando, Ramón , Juan Fernando, Gómez , Diego, Jaramillo-Velásquez , Daniel, Bermúdez , Sonia, Useche , Nicolás, Pineda , Diego, Cifuentes , Hernando, Becerra, Antonio, Muñoz , Álvaro, Santoyo , Nicolás, Ruíz-Patiño , Alejandro, Sotelo , Carolina, Archila , Pilar, Rodríguez , July, Ávila , Jenny, Ordoñez-Reyes, Camila, García-Robledo , Juan Esteban, Ricaurte , Luisa, Rojas , Leonardo, Feo , Oscar, Burgos , Remberto, Ramírez , Carlos, Arrieta , Oscar, Zatarain-Barrón , Lucía, Vargas , Carlos, Carranza , Hernán, Otero , Jorge, and Cardona , Andrés F.

Abstract

Introduction: Mutations in the promoter region of telomerase reverse transcriptase occur frequently in meningiomas.Objective: To estimate the prognostic importance of telomerase reverse transcriptase mutations in Colombian patients with grades II and III meningioma.Materials and methods: This was a multicenter retrospective cohort study of patients diagnosed with refractory or recurrent WHO grades II and III meningiomas, recruited between 2011 and 2018, and treated with systemic therapy (sunitinib, everolimus ± octreotide, and bevacizumab). Mutation status of the telomerase reverse transcriptase promoter was established by PCR.Results: Forty patients were included, of which telomerase reverse transcriptase mutations were found in 21 (52.5%), being C228T and C250T the most frequent variants with 87.5 % and 14.3 %, respectively. These were more frequent among patients with anaplastic meningiomas (p=0.18), with more than 2 recurrences (p=0.04); and in patients with parasagittal region and anterior fossa lesions (p=0.05). Subjects characterized as having punctual mutations were more frequently administered with everolimus, sunitinib and bevacizumab drug series (p=0.06). Overall survival was 23.7 months (CI95% 13.1-34.2) and 43.4 months (CI95% 37.5-49.3; p=0.0001) between subjects with and without mutations, respectively. Multivariate analysis showed that the number of recurrences and the presence of telomerase reverse transcriptase mutations were tthe only variables that negatively affected overall survival.Conclusions: Mutations in telomerase reverse transcriptase allows the identification of high-risk patients and could be useful in the selection of the best medical treatment., Introducción. En los meningiomas, ocurren con frecuencia mutaciones en la región promotora de la transcriptasa inversa de la telomerasa.Objetivo. Estimar la importancia pronóstica de las mutaciones de la transcriptasa inversa de la telomerasa en pacientes colombianos con meningiomas de grados II y III.Materiales y métodos. Es un estudio de cohorte, retrospectivo y multicéntrico, que incluyó pacientes con diagnóstico de meningioma persistente o recidivante, de grados II y III, según la clasificación de la OMS, reclutados entre el 2011 y el 2018, con tratamiento sistémico (sunitinib, everolimus con octreótido o sin él, y bevacizumab). El estado de la mutación del promotor de la transcriptasa inversa de la telomerasa se determinó por medio de la PCR. Resultados. Se incluyeron 40 pacientes, en 21 (52,5 %) de los cuales se encontraron mutaciones en la transcriptasa inversa de la telomerasa, siendo las variantes más frecuentes la C228T (87,5 %) y la C250T (14,3 %). Estas fueron más frecuentes entre los pacientes con meningiomas anaplásicos (p=0,18), en aquellos con más de dosrecurrencias (p=0,04), y en los que presentaron lesiones en la región parasagital y la fosa anterior (p=0,05). Los sujetos caracterizados por tener alteraciones puntuales fueron tratados con mayor frecuencia con la serie de medicamentos everolimus, sunitinib y bevacizumab (p=0,06). Tras el inicio del tratamiento médico, la supervivencia global fue de 23,7 meses (IC95% 13,1-34,2) en los pacientes con mutaciones y, de 43,4 meses (IC95% 37,5-49,3), entre aquellos sin mutaciones (p=0,0001).Los resultados del análisis multivariado demostraron que, únicamente, el número de recurrencias y la presencia de mutaciones en el gen de la transcriptasa inversa de la telomerasa, fueron factores que afectaron negativamente la supervivencia global. Conclusiones. Las mutaciones en el gen promotor de la transcriptasa inversa de la telomerasa permiten identificar los pacientes con alto riesgo, cuya detección podría ser de

Published
2022

28. Understanding the molecular profiling of diffuse gliomas classification: A brief overview.

Author

Ordóñez Rubiano, Edgar G., Baldoncini, Matías, Lucía Cómbita, Alba, Payán-Gómez, César, Gómez-Amarillo, Diego F., Hakim, Fernando, Fernanda Figueredo, Luisa, Forlizzi, Valeria, Castillo Rangel, Carlos, Luzzi, Sabino, Campero, Alvaro, and Parra-Medina, Rafael

Abstract

Background: Gliomas represent almost 30% of all primary brain tumors and account for 80% of malignant primary ones. In the last two decades, significant progress has been made in understanding gliomas' molecular origin and development. These advancements have demonstrated a remarkable improvement in classification systems based on mutational markers, which contribute paramount information in addition to traditional histology-based classification. Methods: We performed a narrative review of the literature including each molecular marker described for adult diffuse gliomas used in the World Health Organization (WHO) central nervous system 5. Results: The 2021 WHO classification of diffuse gliomas encompasses many molecular aspects considered in the latest proposed hallmarks of cancer. The outcome of patients with diffuse gliomas relies on their molecular behavior and consequently, to determine clinical outcomes for these patients, molecular profiling should be mandatory. At least, the following molecular markers are necessary for the current most accurate classification of these tumors: (1) isocitrate dehydrogenase (IDH) IDH-1 mutation, (2) 1p/19q codeletion, (3) cyclin-dependent kinase inhibitor 2A/B deletion, (4) telomerase reverse transcriptase promoter mutation, (5) a-thalassemia/mental retardation syndrome X-linked loss, (6) epidermal growth factor receptor amplification, and (7) tumor protein P53 mutation. These molecular markers have allowed the differentiation of multiple variations of the same disease, including the differentiation of distinct molecular Grade 4 gliomas. This could imply different clinical outcomes and possibly impact targeted therapies in the years to come. Conclusion: Physicians face different challenging scenarios according to the clinical features of patients with gliomas. In addition to the current advances in clinical decision-making, including radiological and surgical techniques, understanding the disease's molecular pathogenesis is paramount to improving the benefits of its clinical treatments. This review aims to describe straightforwardly the most remarkable aspects of the molecular pathogenesis of diffuse gliomas. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Ventriculo-atrial shunt. Comparison of an ultrasound-guided peel-away technique versus conventional technique in the management of normal pressure hydrocephalus: A retrospective cohort

Author

Segura-Hernández, Andrés, primary, Hakim, Fernando, additional, Ramón, Juan F., additional, Jiménez-Hakim, Enrique, additional, Mejía-Cordovez, Juan A., additional, Quintero-Rueda, Diego, additional, Araque-Puello, Yessid, additional, Pedraza-Ciro, Camila, additional, Leal-Isaza, Juan P., additional, Mendoza-Mantilla, Juliana, additional, Robles, Vanesa, additional, Gonzalez, Martina, additional, Jaramillo-Velásquez, Daniel, additional, and Gómez, Diego F., additional

Published
2021
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32. Efficacy of Osimertinib Plus Bevacizumab In Glioblastoma Patients With Simultaneous EGFR Amplification And EGFRvIII Mutation

Author

Jaramillo-Velásquez, Daniel, primary, Cardona, Andrés F., additional, Ruiz-Patiño, Alejandro, additional, Polo, Carolina, additional, Jiménez, Enrique, additional, Hakim, Fernando, additional, Gómez, Diego F, additional, Ramón, Juan Fernando, additional, Cifuentes, Hernando, additional, Mejía, Juan Armando, additional, Salguero, Fernando, additional, Ordoñez, Camila, additional, Muñoz, Álvaro, additional, Bermúdez, Sonia, additional, Useche, Nicolas, additional, Pineda, Diego, additional, Ricaurte, Luisa, additional, Zatarain-Barrón, Zyanya Lucia, additional, Rodríguez, July, additional, Avila, Jenny, additional, Rojas, Leonardo, additional, Jaller, Elvira, additional, Sotelo, Carolina, additional, Garcia-Robledo, Juan Esteban, additional, Santoyo, Nicolas, additional, Rolfo, Christian, additional, Rosell, Rafael, additional, and Arrieta, Oscar, additional

Published
2021
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34. Expert Case Reviewers

Author

Abdallah, Anas, Al-Habib, Amro F., Al-Mahfoudh, Rafid, Albert, Todd J., Allen, Richard, Almendral, Andrés, Baaj, Ali A., Bagley, Carlos, Barakat, Ahmed S., Barrenechea, Ignacio, Luis Bazán, Pedro, Bellabarba, Carlo, Benneker, Lorin M., Berven, Sigurd, Bhatia, Nitin N., Bilsky, Mark H., Bolger, Ciaran, Boriani, Stefano, Bransford, Richard J., Bydon, Mohamad, Campero, Alvaro, Casey, Adrian, Chen, Selby G., Cheung, Jason, Chi, John, Chou, Dean, Clarke, Michelle, Cofano, Fabio, Daffner, Scott, Dea, Nicolas, Gordon Deen Jr., H., Dewald, Christopher J., Rodrigo Diaz Iniguez, Luis, Ehresman, Jeffrey, El-Fiki, Mohamed, Elder, Benjamin, Elnady, Belal, Eltahawy, Hazem, Espinoza-Garcia, Esteban F., Farber, Harrison, Fehlings, Michael G., Freedman, Brett A., Frisoli, Fabio, Garg, Bhavuk, Gokaslan, Ziya, Golan, Jeff D., Gómez, Diego F, Eduardo Guzman Prenk, Jorge, Hakim, Fernando, Hara, Takeshi, Harrop, James S., Hassanzadeh, Hamid, Heller, John G., Hobson, Sandra, Hoh, Daniel J., Holly, Langston T., Hsieh, Patrick C., Huang, Meng, Huddleston, Paul M., Itshayek, Eyal, Jallo, George I., Kalani, Maziyar A., Laufer, Ilya, Lawton, Michael T., Lazary, Aron, Lenke, Lawrence G., Levi, Allan D., Li, Yingda, Liu, Ann, Lo, Sheng-Fu, Lu, Daniel C., Mayer, Rory, Meng, Tong, Moran, Catherine, Mummaneni, Praveen, Nasi, Davide, Navarro-Ramirez, Rodrigo, Navarro Bonnet, Jorge, Niu, Tianyi, Núñez-Pereira, Susana, Pairojboriboon, Sutipat, Pennicooke, Brenton, Phalak, Manoj, Phillips, Frank M., Rajesh, Alugolu, Fernando Ramon, Juan, Daniel Riew, K., Schmidt, Meic, Sciubba, Daniel M., Sikora, Jakub, Smith, Justin, Soliman, Mohamed A.R., Than, Khoi D., Theodore, Nicholas, Tokuhashi, Yasuaki, Vaccaro, Alexander R., Veeravagu, Anand, Roberto Vialle, Luiz, Wang, Michael Y., Weber, Clemens, Witham, Timothy, Wolinsky, Jean-Paul, Yampolsky, Claudio, Yoon, Jang, and Zarate Kalfopulos, Baron

Published
2023
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35. Cerebrospinal fluid closing pressure-guided tap test for the diagnosis of idiopathic normal pressure hydrocephalus: A descriptive cross-sectional study

Author

Gómez-Amarillo, Diego Fernando, primary, Pulido, Luis Fernando, additional, Mejía, Isabella, additional, García-Baena, Catalina, additional, Cárdenas, María Fernanda, additional, Gómez, Lina María, additional, Fuentes, Yuli Viviana, additional, Volcinschi-Moros, Daniela, additional, Jaramillo-Velásquez, Daniel, additional, Ramón, Juan Fernando, additional, Mejía, Juan Armando, additional, Jiménez, Enrique, additional, and Hakim, Fernando, additional

Published
2020
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36. Contributors

Author

Aalbers, Marlien W., Abou-El-Hassan, Hadi, Acosta, Frank, Adelson, P. David, Adler, John R., Jr., Agarwal, Vijay, Aghi, Manish K., Ahluwalia, Manmeet S., Ahmed, A. Karim, Ajler, Pablo, Akinduro, Oluwaseun O., Albuquerque, Felipe C., Aldana, Philipp R., Alluri, Ram K., Alvi, Mohammed Ali, Amendola, Luca, Amin-Hanjani, Sepideh, Ammerman, Joshua M., Anderson, William, Andrade-Barazarte, Hugo, Appelboom, Geoff, Arnold, Paul M., Asthagiri, Ashok, Aulakh, Sonikpreet, Aziz, Khaled M., Aziz, Tipu, Bakhsheshian, Joshua, Ball, Perry A., Bandiera, Stefano, Barbaro, Nicholas M., Barnard, Zachary R., Barrow, Daniel L., Beaumont, Thomas L., Bederson, Joshua, Beier, Alexandra D., Bellabarba, Carlo, Bello, Lorenzo, Belzberg, Alan J., Ben-Haim, Sharona, Ben-Shalom, Netanel, Bender, Matthew T., Bendok, Bernard R., Benes, Ludwig, Benzel, Edward C., Bertalanffy, Helmut, Bettegowda, Chetan, Bhagat, Priyal Vinod, Bi, Wenya Linda, Bijanki, Kelly, Bishop, Allen T., Bisson, Erica F., Black, Keith L., Blondel, Benjamin, Boahene, Kofi, Bohnen, Angela M., Bollo, Robert J., Bookland, Markus, Borghei, Alireza, Borghei-Razavi, Hamid, Boriani, Stefano, Borkar, Sachin A., Bova, Frank J., Brahimaj, Bledi C., Brandt, Ryan J., Bransford, Richard J., Brotchi, Jacques, Brown, Benjamin L., Bruce, Jeffrey N., Bruneau, Michael, Buchanan, Ian A., Burchiel, Kim J., Burke, Timothy G., Bydon, Ali, Bydon, Mohamad, Byrne, Richard W., Cabral, Gustavo Augusto Porto Sereno, Cacciola, Francesco, Campos, Jessica K., Caplan, Justin M., Caputy, Anthony J., Cardinale, Francesco, Carlstrom, Lucas P., Carrau, Ricardo L., Carter, Bob S., Castana, Laura, Castillo-Velazquez, Gabriel, Chaichana, Kaisorn L., Chanan-Khan, Asher, Chang, Edward F., Chang, Steven D., Chari, Aswin, Chen, Ching-Jen, Chen, Douglas, Chen, James, Chen, Selby, Chern, Joshua J., Chi, John H., Chiocca, E. Antonio, Chitale, Rohan, Chitnavis, Bhupal, Choudhri, Omar A., Chu, Ray M., Clifton, William, Cohen, Alan R., Cohen, Salomon, Colby, Geoffrey P., Cole, Tyler S., Consales, Alessandro, Coon, Alexander L., Cooper, Jared B., Copeland, William R., Coric, Domagoj, Corl, Frank M., Corliss, Brian M., Corti, Marcelo, Cossu, Massimo, Currier, Bradford L., Curry, William T., Dabus, Guilherme, Dahdaleh, Nader S., Dailey, Andrew T., Daniels, David J., Dardis, Ronan M., Das, Sunit, Dasenbrock, Hormuzdiyar H., Day, Arthur L., Biase, Gaetano De, Garza Ramos, Rafael De la, Deen, H. Gordon, Deletis, Vedran, Detsky, Jay, Dlouhy, Brian J., Domingo, Ricardo A., Domino, Joseph, Donaldson, Angela M., Dornbos, David, Dorsi, Michael J., Reis, Cassius Vinicius Corrêa Dos, Ducker, Thomas B., Duffau, Hugues, Dunn, Ian F., D’Amico, Randy S., Eggenberger, Eric R., Ehresman, Jeff, El Naga, Ashraf N., Elarjani, Turki, Elder, Benjamin D., Elsharkawy, Ahmed, Epstein, Nancy E., Erkmen, Kadir, Errico, Thomas J., Eskey, Clifford J., Evans, Linton, Everson, Megan C., Fei, Naomi, Fessler, Richard G., Filler, Aaron G., Flores, Bruno C., Foley, Kevin T., Foroni, Roberto I., Forte, Antonio J., Fountas, Kostas N., Fox, W. Christopher, Freeman, William David, Friedman, William Alan, Frim, David M., Frisoli, Fabio, Fujimura, Miki, Ganaha, Sara, Gandhi, Dheeraj, Gandhi, Sirin, Garrett, Mark, Garzon-Muvdi, Tomas, Gasbarrini, Alessandro, Gassie, Kelly, Geisler, Fred H., Georgoulis, George, Gill, Brian J.A., Goehre, Felix, Goel, Atul, Goel, Gunjan, Gokaslan, Ziya L., Gold, Katherine G., Gomez, Diego F., Gonzalez, L. Fernando, Goodwin, C. Rory, Gordon, Chad R., Goyal, Anshit, Graffeo, C.S., Grande, Andrew W., Grandhi, Ramesh, Green, Alexander L., Greenfield, Jeffrey P., Grewal, Sanjeet S., Groves, Mari L., Guan, Jian, Guinto, Gerardo, Gullan, Richard, Gupta, Gaurav, Gupta, Nalin, Gupta, Vivek, Hah, Raymond J., Hakim, Fernando, Halalmeh, Dia Radi, Haldeman, Clayton L., Haranhalli, Neil, Hardesty, Douglas A., Hardigan, Trevor, Harrop, James S., Hartnett, Sara, Heinze, Stefan, Hernesniemi, Juha, Hersh, David S., Hidalgo, Joaquin, Hill, Travis, Hindoyan, Kevork N., Ho, Olivia, Hoh, Brian L., Hopkins, L. Nelson, Hsu, Wesley, Huang, Judy, Huang, Michael, Huff, Wei X., Huq, Sakibul, Hussain, Zain, Ironside, Natasha, Iyer, Rajiv R., Jabbour, Pascal M., Jackson, Christina, Jackson, Christopher M., Jahromi, Behnam Rezai, Jallo, George I., Jaume, Alejandra, Javadpour, Mohsen, Jea, Andrew, Jentoft, Mark, Jho, David H., Jho, Diana H., Jho, Hae-Dong, Jiang, Bowen, Joyce, Evan, Kalani, M. Yashar S., Kapsalaki, Eftychia Z., Kaplitt, Michael G., Karas, Patrick, Karatayli-Ozgursoy, Selmin, Kawase, Takeshi, Kehler, Uwe, Kerezoudis, Panagiotis, Kern, Drew S., Khan, Farhan A., Khan, Nickalus R., Khu, Kathleen, Kim, Daniel H., Kirsch, Matthias, Klinge, Petra, Koch, Matthew J., Kogan, Michael, Kolcun, John Paul G., Kondziolka, Douglas, Korinth, Marcus Christopher, Kotecha, Rupesh, Krex, Dietmar, Krishna, Chandan, Krishnan, Kartik G., Krishnaney, Ajit, Kshettry, Varun R., Lacy, Maureen, Ladner, Travis R., Landeiro, Jose Alberto, Lang, Frederick F., Lang, Michael J., Larsen, Alexandra Giantini, Laurent, Dimitri, Lawton, Michael T., Lee, Bryan S., Levi, Allan, Levivier, Marc, Levy, Elad I., Lim, Michael, Lin, Li-Mei, Lin, Michelle, Erland Lind, Göran, Linderoth, Bengt, Link, Michael J., Lo Russo, Giorgio, Loftus, Christopher M., Longhi, Michele, Lonser, Russell R., Louie, Christopher E., Lu, Daniel C., Ludtka, Christopher, Lundy, Larry B., Magge, Subu N., Malessy, Martijn J.A., Maniker, Allen H., Manley, Geoffrey T., Maralani, Peiman, Marenco-Hillembrand, Lina, Martinez-Sosa, Meleine, Mascitelli, Justin R., Mazur, Marcus D., McCormick, Paul C., Mena-Bernal, José Hinojosa, Menezes, Arnold H., Meyer, Fredric B., Middlebrooks, Erik H., Midha, Rajiv, Mikula, Anthony, Miller, David, Miller, Jonathan P., Mirza, Bilal, Mirzadeh, Zaman, Mocco, J., Molina, Camilo A., Montaser, Alaa S., Morcos, Jacques J., Morgan, Chad J., Mostofi, Abteen, Muftuoglu, Yagmur, Myrehaug, Sten, Nabavi, Arya, Nanaszko, Michael J., Nanda, Pranav, Naragum, Varun, Nasser, Rani, Nathal, Edgar, Nguyen, Timothy K., Nibali, Marco Conti, Nicolato, Antonio, Nimmagadda, Anitha, North, Richard B., Nottmeier, Eric, Noureldine, Mohammad Hassan A., Oakes, W. Jerry, Ogilvy, Christopher S., Ojemann, Jeffrey G., Ojemann, Steven, Okonkwo, David O., Olivi, Alessandro, Olomu, Osarenoma U., Orlev, Alon, Osburn, Brooks, Ota, Nakao, Otto, Bradley A., Pang, Dachling, Parney, Ian, Pascual, José María, Patel, Aman B., Patel, Anoop, Patel, Smruti K., Patir, Rana, Penn, Richard D., Pennington, Zachary, Pepa, Giuseppe Maria Della, Perdomo-Pantoja, Alexander, Pereira, Erlick A.C., Perez-Cruet, Mick J., Peris-Celda, Maria, Perry, A., Perry, Avital, Pessina, Federico, Peterson, Jennifer L., Pham, Martin H., Pichelmann, Mark, Pinheiro-Neto, Carlos D., Pirgousis, Phillip, Pitts, Lawrence H., Placide, Rick J., Plaha, Puneet, Polifka, Adam J., Pondaag, Willem, Post, Kalmon D., Potts, Matthew B., Poulsgaard, Lars, Prete, Alessandro, Prevedello, Daniel M., Prieto, Ruth, Puffer, Ross C., Quevedo-Valdes, Pablo A., Quiñones-Hinojosa, Alfredo, Quintana, Leonidas M., Sr., Rahmathulla, Gazanfar, Rahme, Rudy J., Ramhmdani, Seba, Ramon, Juan F., Ramos-Fresnedo, Andres, Ramos-Zuniga, Rodrigo, Sr., Ranalli, Nathan J., Ranjan, Manish, Rapp, Aaron, Ravindra, Vijay M., Recinos, Pablo F., ReFaey, Karim, Régis, Jean, Relyea, Katherine, Resnick, Daniel K., Richardson, Angela M., Rigamonti, Daniele, Riva, Marco, Riva, Matteo, Rizzi, Michele, Rochkind, Shimon, Rolston, John D., Rosenberg, William S., Rosenwasser, Robert H., Roser, Florian, Rossi, Marco, Rowland, Nathan C., Rutka, James T., Rymarczuk, George N., Sahgal, Arjun, Sala, Francesco, Salle, Federico, Sani, Sepehr, Santiago, Gabriel F., Salvatori, Roberto, Martinez Santos, Jaime L., Sarris, Christina E., Savastano, Luis E., Saxena, Amar, Schackert, Gabriele, Prof, Schmidt, Meic H., Schroeder, Henry W.S., Prof, Schwab, Joseph, Schwartz, Theodore H., Sciortino, Tommaso, Sciubba, Daniel M., Scott, Kyle W., Scoville, Jonathan P., See, Alfred P., Sekula, Raymond F., Jr., Shad, Amjad, Shah, Jugal, Shaibani, Ali, Shaikhouni, Ammar, Sharma, Manish S., Sheehan, Jason, Sheehy, John Paul, Sheth, Sameer, Shi, Changbin, Shimony, Nir, Shin, Alexander Y., Siddiqui, Adnan H., Silveira, Roberto Leal, Simmons, Nathan, Sindou, Marc, Sinisi, Marco, Smith, Edward R., Smith, Joseph R., Smith, Kyle A., Smyth, Matthew D., Soliman, Hany, Souweidane, Mark M., Spagnuolo, Edgardo, Spetzler, Robert F., Spinner, Robert J., Stapleton, Christopher J., Stein, Rachel, Steinmetz, Michael P., Stone, Scellig, Stricsek, Geoffrey P., Suarez-Meade, Paola, Sughrue, Michael E., Suk, Ian, Sun, Daniel Q., Sur, Samir, Sure, Ulrich, Sweid, Ahmad, Tafel, Ian, Tamargo, Rafael J., Tawk, Rabih G., Tew, John M., Jr., Theodore, Nicholas, Thompson, B. Gregory, Jr., Thompson, John A., Tian, Fucheng, Tirakotai, Wuttipong, Tjoumakaris, Stavropoula, Todnem, Nathan, Tominaga, Teiji, Trifiletti, Daniel M., Tripathi, Shashwat, Tseng, Eric, Tubbs, R. Shane, Tulamo, Riikka, Tuleasca, Constantin, Turkmani, Ali H., Vakharia, Kunal, Van Gompel, Jamie J., Vasudeva, Viren S., Velasco, Ana Luisa, Velasco, Francisco, Velat, Gregory J., Venur, Vyshak Alva, Verlicchi, Angela, Vivas-Buitrago, Tito, Vlasak, Alexander L., Vrionis, Frank D., Wainwright, John Varmaa, Wallace, M. Christopher, Waqas, Muhammad, Watridge, Clarence B., Weiss, Nirit, Welz, Matthew E., Westbroek, Erick M., Wharen, Robert E., Wildrick, David M., Wilkinson, D. Andrew, Winfree, Christopher J., Witham, Timothy, Wolff, Amir, Wolinsky, Jean-Paul, Wu, Kyle C., Xavier, Shaun, Yaeger, Kurt, Yampolsky, Claudio, Yassari, Reza, Yolcu, Yagiz Ugur, Yu, Alexander K., Zager, Eric L., Zanotti, Bruno, Zileli, Mehmet, and Zivelonghi, Emanuele

Published
2022
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37. Recurrent pleomorphic anaplastic xanthoastrocytoma and response to combination of carmustine and bevacizumab, a case report

Author

Castro, Christian David, Jiménez, Enrique, Useche, Nicolás, Hakim, Fernando, Bermúdez, Sonia, Rojas, Leonardo, Ruiz-Patiño, Alejandro, and Cardona, Andrés Felipe

Subjects
carmustina (DeCS), carmustine (MeSH), glioma, antineoplastic agents, antineoplásicos, bevacizumab, radioterapia, radiotherapy
Abstract

RESUMEN Se expone el caso de una mujer de 19 años a quien se le realizó el diagnóstico de un xantoastrocitoma pleomórfico anaplásico parietooccipital izquierdo, neoplasia poco frecuente que suele presentarse en la población pediátrica y en los adultos jóvenes. Dicho tumor debuta generalmente con crisis convulsivas y sus características histológicas patognomónicas son el pleomorfismo celular, la vacuolización lipídica de su citoplasma y la reactividad a la proteína ácida fibrilar glial (PAFG) y S100. El estudio de nuevos marcadores que puedan brindar otras oportunidades terapéuticas ha permitido encontrar mutaciones en el oncogén BRAF. Este tumor presenta una variante anaplásica más agresiva que se trata con cirugía y quimiorradiación. En nuestro caso, después de varias progresiones a otras intervenciones, se utilizó bevacizumab y carmustine como tratamiento de segunda línea con respuesta completa. SUMMARY The case of a young woman of 19-years-old is presented; whom the diagnosis was made of a left parietal-occipital xanthoastrocytoma pleomorphic anaplastic; this neoplasia is rare and usually affects the pediatric and young adult population. This generally debuts with seizures and their pathognomonic histologic characteristics are the pleomorphic cells with cytoplasmatic lipid vacuolation and the reactivity of glial fibrillary acidic protein (GFAP) and S100. The study of new markers that may provide other therapeutic opportunities has allowed finding mutations in the BRAF oncogene. This tumor has a more aggressive anaplastic variant that is treated with surgery and chemoradation. In our case after several progressions to other interventions, we used bevacizumab and carmustine as second-line treatment obtaining complete response.

Published
2018

38. Systemic management of malignant meningiomas: A comparative survival and molecular marker analysis between Octreotide in combination with Everolimus and Sunitinib

Author

Cardona, Andrés F., primary, Ruiz-Patiño, Alejandro, additional, Zatarain-Barrón, Zyanya Lucia, additional, Hakim, Fernando, additional, Jiménez, Enrique, additional, Mejía, Juan Armando, additional, Ramón, Juan Fernando, additional, Useche, Nicolás, additional, Bermúdez, Sonia, additional, Pineda, Diego, additional, Cifuentes, Hernando, additional, Rojas, Leonardo, additional, Ricaurte, Luisa, additional, Pino, Luis Eduardo, additional, Balaña, Carmen, additional, and Arrieta, Oscar, additional

Published
2019
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42. Profiling response to carmustine/bevacizumab in recurrent glioblastoma.

Author

Rojas, Leonardo, primary, Cardona, Andres F., additional, Wills, Beatriz, additional, Arrieta, Oscar, additional, Vargas, Carlos A., additional, Carranza, Hernan, additional, Otero, Jorge M., additional, Useche, Nicolas, additional, Bermudez, Sonia, additional, Jimenez, Enrique, additional, Hakim, Fernando, additional, and Balana, Carmen, additional

Published
2016
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43. Genotyping low-grade gliomas among Hispanics

Author

Cardona, Andrés Felipe, primary, Rojas, Leonardo, additional, Wills, Beatriz, additional, Behaine, José, additional, Jiménez, Enrique, additional, Hakim, Fernando, additional, Useche, Nicolás, additional, Bermúdez, Sonia, additional, Arrieta, Oscar, additional, Mejía, Juan Armando, additional, Ramón, Juan Fernando, additional, Carranza, Hernán, additional, Vargas, Carlos, additional, Otero, Jorge, additional, González, Diego, additional, Rodríguez, July, additional, Ortiz, León Darío, additional, Cifuentes, Hernando, additional, and Balaña, Carmen, additional

Published
2016
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44. Efficacy and safety of Levetiracetam vs. other antiepileptic drugs in Hispanic patients with glioblastoma.

Author

Cardona, Andrés F., Rojas, Leonardo, Wills, Beatriz, Bernal, Laura, Ruiz-Patiño, Alejandro, Arrieta, Oscar, Hakim, Enrique Jiménez, Hakim, Fernando, Mejía, Juan Armando, Useche, Nicolás, Bermúdez, Sonia, Carranza, Hernán, Vargas, Carlos, Otero, Jorge, Mayor, Luis Carlos, Ortíz, León Darío, Franco, Sandra, Ortíz, Carlos, Gil-Gil, Miguel, and Balaña, Carmen

Abstract

Epilepsy is a common symptom in patients with glioblastoma (GB). 213 patients with GB from RedLANO follow-up registry were included. All patients underwent surgery, if feasible, followed by chemoradiation based on temozolomide (Stupp platform). Information was recorded regarding demographics, seizure timing, anti-epileptic drugs (AEDs), dosage, time to next seizure, total seizures in 6 months, and main side effects of AEDs. The relationship between epilepsy treatment and overall survival (OS) was evaluated. Mean age was 53 years old and 56.8% were male. Seventy-eight patients (37%) were treated with levetiracetam (LEV), 27% were given another AED and 36% did not require any AED. Choice of AED was not associated with age (p = 0.67), performance status (p = 0.24) or anatomic tumor site (p = 0.34). Seizures and AED requirement were greater in those having primary GB (p = 0.04). After starting an AED, the mean time until next crisis was 9.9 days (SD ± 6.3), which was shorter in those receiving LEV (p = 0.03); mean number of seizures during the first 3 and 6 months were 2.9 and 4, respectively. Most patients treated with LEV (n = 46) required less than two medication adjustments compared to those treated with other AEDs (p = 0.02). Likewise, less patients exposed to LEV required a coadjuvant drug (p = 0.04). Additionally, patients receiving LEV had significantly less adverse effects compared to patients treated with another AED. OS was significantly higher in the group treated with LEV compared to other AEDs (25.5 vs. 17.9 months; p = 0.047). Patients treated with LEV had better seizure control and longer OS compared to other AEDs. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Abscesos cerebrales por Nocardia spp en paciente inmunocompetente

Author

García Roldán, Nicolás, Chater Cure, George, Peña Quiñones, Germán, and Hakim, Fernando

Subjects
Biopsia, Brain abscess, Biopsy, Estereotáxica, Absceso cerebral, Nocardia
Abstract

La nocardiosis es una infección localizada o diseminada causada por un microorganismo aeróbico. En el sistema nervioso central (SNC) es poco común, sólo 2% de todos los abscesos cerebrales. Usualmente afecta a los pacientes inmunocomprometidos y es muy rara en los inmunocompetentes. En ambos causa una morbimortalidad significativa. No hay un tratamiento ideal; la cirugía desempeña un papel importante, ya que facilita el diagnóstico bacteriológico y en ocasiones alivia la presión intracraneana. Se presenta un paciente de 58 años con cefalea intensa y hemiparesia. El estudio de resonancia magnética demostró múltiples lesiones cerebrales. Se hicieron estudios de extensión para metástasis cerebrales, pero todos fueron negativos. Se efectuó una biopsia cerebral esterotáxica, negativa para malignidad en los cultivos creció una Nocardia spp. El manejo antibiótico ocasionó mejoría clínica significativa y a los 18 meses post-tratamiento el paciente está asintomático. Nocardiosis can be a localized or disseminated infection caused by an aerobic microorganism. In the central nervous system (CNS) is rare, only 2% of all brain abscesses. It usually affects immunocompromised patients and is uncommon in immunocompetent, but cause significant morbidity and mortality in both. There is no ideal treatment, surgery plays an important role because it facilitates the bacteriological diagnosis and sometimes relieve intracranial pressure. This paper reports a patient of 58 years with severe headache and hemiparesis. The MRI showed multiple brain lesions. Studies to rule out brain metastases were done, but all were negative. One stereotactic brain biopsy, negative for malignancy was positive for Nocardia spp. The antibiotic treatment gave a significant clinical improvement and 18 months after treatment, patient is asymptomatic.

Published
2010

46. BI-05MOLECULAR PROFILING OF LOW GRADE GLIOMAS (LGG) IN COLOMBIA (ONCologROUP)

Author

Cardona, Andres, Jimenez, Enrique, Hakim, Fernando, Useche, Nicolas, Bermudez, Sonia, Arrieta, Oscar, Behaine, Jose, Rodriguez, July, Carranza, Hernan, Otero, Jorge, Vargas, Carlos, Rojas, Leornardo, Ortiz, Leon Dario, Cardona, Andres, Jimenez, Enrique, Hakim, Fernando, Useche, Nicolas, Bermudez, Sonia, Arrieta, Oscar, Behaine, Jose, Rodriguez, July, Carranza, Hernan, Otero, Jorge, Vargas, Carlos, Rojas, Leornardo, and Ortiz, Leon Dario

Abstract

BACKGROUND: LGG are classified as being astrocytoma (DA), oligodendroglioma (OD) or mixed glioma (OA). TP53-m and 1p19q codeletion have been the main molecular abnormalities recorded to date. IDH1/2 mutations have been described in up to 85% of LGG. It has recently been found that ATRX plays a significant role in glioma oncogenesis. METHODS: We searched for P53 and Olig2 protein expression, MGMT methylation status (pMGMT), 1p19q codeletion and IDH/ATRX status in 63 Colombian LGG patients (pts). Overall survival (OS) rate was estimated and compared between groups and according to genotype. RESULTS: Mean age was 40.1-yo (±12.3), 50% of the pts were male, mean lesion diameter was 41.7 mm (±17.2 mm) and histological distribution was 61.9%, 25.4% and 12.7% for AD, OD and OA, respectively. Surgical resection was total in 47.6%, subtotal in 31.7% and biopsy was performed in 20.6% of the cases. Alterations in IDH1/2 were found in 57.1%, pMGMT+ in 65.1%, overexpression of p53 and Olig2 in 30.2% and 44.4%, and 1p19q codeletion in 34.9%. The presence of alterations in ATRX was analysed in 25 patients, being positive in 16% (all IDH1 + /1p19q- ). Median follow-up was 15.8 months (95%CI 7.6-42.0), OS was 39.2 months (95%CI 1.3-114) and the variables positively modifying OS were pMGMT+ (p = 0.004), 1p19q codeletion (p = 0.015), the extension of surgical intervention (p = 0.011) and the number of lobes involved (p = 0.021). Multivariate analysis showed that pMGMT and 1p19q codeletion modified the OS in our population (p = 0.039 and 0.047, respectively). CONCLUSIONS: This is the first study which has evaluated the molecular profile in LGG pts from Latin-America. Our findings confirmed the prognostic relevance of pMGMT and 1p19q codeletion, without finding a positive relation for IDH1/2 mutations. This finding could have been explained by sample size and selection bias. Alterations in ATRX are limited to the population of pts having AD/OA and IDH1 + /1p19q

Published
2014

47. Molecular profiling of low-grade gliomas (LGG) in Colombia (ONCOLGroup).

Author

Cardona, Andres F., primary, Behaine, Jose, additional, Jimenez, Enrique, additional, Hakim, Fernando, additional, Useche, Nicolas, additional, Bermudez, Sonia, additional, Arrieta, Oscar, additional, Mejia, Juan A., additional, Carranza, Hernan, additional, Otero, Jorge M., additional, Benavidez, Diego, additional, Edy, Pierre M., additional, Balañá, Carmen, additional, Rodriguez, July, additional, and Ortiz, Leon D., additional

Published
2014
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48. RANO, más que ficción.

Author

Useche, Nicolás, primary, Bermúdez, Sonia, additional, Cardona, Andrés Felipe, additional, Jiménez, Enrique, additional, Hakim, Fernando, additional, Peña, Germán, additional, Mejía, Juan Armando, additional, Aristizábal, Gerardo, additional, Restrepo, Carlos Emilio, additional, Bartels, Carlos, additional, Quintero, Andrés, additional, Carranza, Hernán, additional, Otero, Jorge Miguel, additional, Vargas, Carlos, additional, and Ortiz, León Darío, additional

Published
2013
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50. Tumor teratoide rabdoide atípico en un adulto joven.

Author

Quintero, Carlos Andrés, primary, Castro, Christian, additional, Hakim, Fernando, additional, Useche, Nicolás, additional, Mejía, Marcela, additional, Flórez, Adriana, additional, Bermúdez, Sonia, additional, Velandia, Fernando, additional, García, Alfredo, additional, Ortiz, León Darío, additional, and Cardona, Andrés Felipe, additional

Published
2012
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