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283 results on '"Hakansson N."'

1. Dietary environmental impacts relative to planetary boundaries for six environmental indicators – A population-based study

Author: Hallström, E., Davis, J., Håkansson, N., Ahlgren, S., Åkesson, A., Wolk, A., and Sonesson, U.
Published: 2022
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2. Very-High-Energy $\gamma$-Ray Observations of the Blazar 1ES 2344+514 with VERITAS

Author: Allen, C., Archambault, S., Archer, A., Benbow, W., Bird, R., Bourbeau, E., Brose, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Cardenzana, J. V, Cerruti, M., Chen, X., Christiansen, J. L., Connolly, M. P., Cui, W., Daniel, M. K., Eisch, J. D., Falcone, A., Feng, Q., Fernandez-Alonso, M., Finley, J. P., Fleischhack, H., Flinders, A., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Hütten, M., Håkansson, N., Hanna, D., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nguyen, T., Nieto, D., O'Brien, S., de Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Park, N., Petrashyk, A., Pichel, A., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Telezhinsky, I., Tucci, J. V., Tyler, J., Wakely, S. P., Weinstein, A., Wilhelm, A., and Williams, D. A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present very-high-energy $\gamma$-ray observations of the BL Lac object 1ES 2344+514 taken by the Very Energetic Radiation Imaging Telescope Array System (VERITAS) between 2007 and 2015. 1ES 2344+514 is detected with a statistical significance above background of $20.8\sigma$ in $47.2$ hours (livetime) of observations, making this the most comprehensive very-high-energy study of 1ES 2344+514 to date. Using these observations the temporal properties of 1ES 2344+514 are studied on short and long times scales. We fit a constant flux model to nightly- and seasonally-binned light curves and apply a fractional variability test, to determine the stability of the source on different timescales. We reject the constant-flux model for the 2007-2008 and 2014-2015 nightly-binned light curves and for the long-term seasonally-binned light curve at the $> 3\sigma$ level. The spectra of the time-averaged emission before and after correction for attenuation by the extragalactic background light are obtained. The observed time-averaged spectrum above 200 GeV is satisfactorily fitted (${\chi^2/NDF = 7.89/6}$) by a power-law function with index $\Gamma = 2.46 \pm 0.06_{stat} \pm 0.20_{sys} $ and extends to at least 8 TeV. The extragalactic-background-light-deabsorbed spectrum is adequately fit (${\chi^2/NDF = 6.73/6}$) by a power-law function with index $\Gamma = 2.15 \pm 0.06_{stat} \pm 0.20_{sys} $ while an F-test indicates that the power-law with exponential cutoff function provides a marginally-better fit ($\chi^2/NDF $ = $2.56 / 5 $) at the 2.1$\sigma$ level. The source location is found to be consistent with the published radio location and its spatial extent is consistent with a point source., Comment: 7 pages, 2 figures. Published in Monthly Notices of the Royal Astronomical Society
Published: 2017
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3. Dark Matter Constraints from a Joint Analysis of Dwarf Spheroidal Galaxy Observations with VERITAS

Author: VERITAS Collaboration, Archambault, S., Archer, A., Benbow, W., Bird, R., Bourbeau, E., Brantseg, T., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cerruti, M., Christiansen, J. L., Connolly, M. P., Cui, W., Daniel, M. K., Feng, Q., Finley, J. P., Fleischhack, H., Fortson, L., Furniss, A., Geringer-Sameth, A., Griffin, S., Grube, J., Hütten, M., Håkansson, N., Hanna, D., Hervet, O., Holder, J., Hughes, G., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Koushiappas, S., Krause, M., Kumar, S., Lang, M. J., Lin, T. T. Y., McArthur, S., Moriarty, P., Nieto, D., O'Brien, S., Ong, R. A., Otte, A. N., Park, N., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Trépanier, S., Tucci, J. V., Tyler, J., Wakely, S. P., Weinstein, A., Wilcox, P., Williams, D. A., and Zitzer, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present constraints on the annihilation cross section of WIMP dark matter based on the joint statistical analysis of four dwarf galaxies with VERITAS. These results are derived from an optimized photon weighting statistical technique that improves on standard imaging atmospheric Cherenkov telescope (IACT) analyses by utilizing the spectral and spatial properties of individual photon events. We report on the results of $\sim$230 hours of observations of five dwarf galaxies and the joint statistical analysis of four of the dwarf galaxies. We find no evidence of gamma-ray emission from any individual dwarf nor in the joint analysis. The derived upper limit on the dark matter annihilation cross section from the joint analysis is $1.35\times 10^{-23} {\mathrm{ cm^3s^{-1}}}$ at 1 TeV for the bottom quark ($b\bar{b}$) final state, $2.85\times 10^{-24}{\mathrm{ cm^3s^{-1}}}$ at 1 TeV for the tau lepton ($\tau^{+}\tau^{-}$) final state and $1.32\times 10^{-25}{\mathrm{ cm^3s^{-1}}}$ at 1 TeV for the gauge boson ($\gamma\gamma$) final state., Comment: 14 pages, 9 figures, published in PRD, Ascii tables containing annihilation cross sections limits are available for download as ancillary files with readme.txt file description of limits
Published: 2017
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4. A luminous and isolated gamma-ray flare from the blazar B2 1215+30

Author: VERITAS Collaboration, Abeysekara, A. U., Archambault, S., Archer, A., Benbow, W., Bird, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cerruti, M., Chen, X., Ciupik, L., Cui, W., Dickinson, H. J., Eisch, J. D., Errando, M., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Hutten, M., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nguyen, T., Nieto, D., Ong, R. A., Otte, A. N., Park, N., Pelassa, V., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Santander, M., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Wakely, S. P., Weiner, O. M., Weinstein, A., Wilhelm, A., Williams, D. A., Collaboration, Fermi-LAT, Fegan, S., Giebels, B., Horan, D., Berdyugin, A., Kuan, J., Lindfors, E., Nilsson, K., Oksanen, A., Prokoph, H., Reinthal, R., Takalo, L., and Zefi, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: B2 1215+30 is a BL Lac-type blazar that was first detected at TeV energies by the MAGIC atmospheric Cherenkov telescopes, and subsequently confirmed by the VERITAS observatory with data collected between 2009 and 2012. In 2014 February 08, VERITAS detected a large-amplitude flare from B2 1215+30 during routine monitoring observations of the blazar 1ES 1218+304, located in the same field of view. The TeV flux reached 2.4 times the Crab Nebula flux with a variability timescale of < 3.6 h. Multiwavelength observations with Fermi-LAT, Swift, and the Tuorla observatory revealed a correlated high GeV flux state and no significant optical counterpart to the flare, with a spectral energy distribution where the gamma-ray luminosity exceeds the synchrotron luminosity. When interpreted in the framework of a one-zone leptonic model, the observed emission implies a high degree of beaming, with Doppler factor > 10, and an electron population with spectral index < 2.3., Comment: 8 pages, 3 figures, accepted for publication in The Astrophysical Journal
Published: 2017
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5. A search for spectral hysteresis and energy-dependent time lags from X-ray and TeV gamma-ray observations of Mrk 421

Author: Abeysekara, A. U., Archambault, S., Archer, A., Benbow, W., Bird, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Flinders, A., Fortson, L., Furniss, A., Griffin, S., Hütten, M., Håkansson, N., Hanna, D., Hervet, O., Holder, J., Humensky, T. B., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Krause, M., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nieto, D., O'Brien, S., Ong, R. A., Otte, A. N., Park, N., Pelassa, V., Pohl, M., Popkow, A., Pueschel, E., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Sadeh, I., Santander, M., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Wakely, S. P., Weinstein, A., Wilhelm, A., Williams, D. A., Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Arcaro, C., Babic, A., Banerjee, B., Bangale, P., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Berti, A., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carosi, R., Carosi, A., Chatterjee, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Wilhelmi, E. de Oña, Di Pierro, F., Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Engelkemeier, M., Ramazani, V. Fallah, Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nievas, Nilsson, K., Nishijima, K., Noda, K., Nogués, L., Nöthe, M., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Strzys, M., Surić, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Torres, D. F., Torres-Albà, N., Toyama, T., Treves, A., Vanzo, G., Acosta, M. Vazquez, Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., Hovatta, T., Perez, I. de la Calle, Smith, P. S., Racero, E., and Baloković, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Blazars are variable emitters across all wavelengths over a wide range of timescales, from months down to minutes. It is therefore essential to observe blazars simultaneously at different wavelengths, especially in the X-ray and gamma-ray bands, where the broadband spectral energy distributions usually peak. In this work, we report on three "target-of-opportunity" (ToO) observations of Mrk 421, one of the brightest TeV blazars, triggered by a strong flaring event at TeV energies in 2014. These observations feature long, continuous, and simultaneous exposures with XMM-Newton (covering X-ray and optical/ultraviolet bands) and VERITAS (covering TeV gamma-ray band), along with contemporaneous observations from other gamma-ray facilities (MAGIC and Fermi-LAT) and a number of radio and optical facilities. Although neither rapid flares nor significant X-ray/TeV correlation are detected, these observations reveal subtle changes in the X-ray spectrum of the source over the course of a few days. We search the simultaneous X-ray and TeV data for spectral hysteresis patterns and time delays, which could provide insight into the emission mechanisms and the source properties (e.g. the radius of the emitting region, the strength of the magnetic field, and related timescales). The observed broadband spectra are consistent with a one-zone synchrotron self-Compton model. We find that the power spectral density distribution at $\gtrsim 4\times 10^{-4}$ Hz from the X-ray data can be described by a power-law model with an index value between 1.2 and 1.8, and do not find evidence for a steepening of the power spectral index (often associated with a characteristic length scale) compared to the previously reported values at lower frequencies., Comment: 45 pages, 15 figures
Published: 2016
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6. A Search for Very High-Energy Gamma Rays from the Missing Link Binary Pulsar J1023+0038 with VERITAS

Author: Aliu, E., Archambault, S., Archer, A., Benbow, W., Bird, R., Biteau, J., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Dickinson, H. J., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Flinders, A., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Hütten, M., Håkansson, N., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Lang, M. J., Loo, A., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nguyen, T., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Pandel, D., Park, N., Pelassa, V., Petrashyk, A., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rulten, C., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Wilhelm, A., Williams, D. A., Zitzer, B., Chernyakova, M., and Roberts, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The binary millisecond radio pulsar PSR J1023+0038 exhibits many characteristics similar to the gamma-ray binary system PSR B1259--63/LS 2883, making it an ideal candidate for the study of high-energy non-thermal emission. It has been the subject of multi-wavelength campaigns following the disappearance of the pulsed radio emission in 2013 June, which revealed the appearance of an accretion disk around the neutron star. We present the results of very high-energy gamma-ray observations carried out by VERITAS before and after this change of state. Searches for steady and pulsed emission of both data sets yield no significant gamma-ray signal above 100 GeV, and upper limits are given for both a steady and pulsed gamma-ray flux. These upper limits are used to constrain the magnetic field strength in the shock region of the PSR J1023+0038 system. Assuming that very high-energy gamma rays are produced via an inverse-Compton mechanism in the shock region, we constrain the shock magnetic field to be greater than $\sim$2 G before the disappearance of the radio pulsar and greater than $\sim$10 G afterwards., Comment: 7 pages, 3 figures, accepted for publication in ApJ
Published: 2016
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7. Very High Energy outburst of Markarian 501 in May 2009

Author: Aliu, E., Archambault, S., Archer, A., Arlen, T., Aune, T., Barnacka, A., Behera, B., Beilicke, M., Benbow, W., Berger, K., Bird, R., Bouvier, A., Böttcher, M., Buchovecky, M., Buckley, J. H., Bugaev, V., Cardenzana, J. V, Cerruti, M., Cesarini, A., Chen, X., Ciupik, L., Collins-Hughes, E., Connolly, M. P., Cui, W., Dumm, J., Eisch, J. D., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gall, D., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Hütten, M., Håkansson, N., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Khassen, Y., Kieda, D., Krause, M., Krawczynski, H., Krennrich, F., Lang, M. J., Madhavan, A. S, Maier, G., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Orr, M., Otte, A. N., Pandel, D., Park, N., Pelassa, V., Perkins, J. S., Pichel, A., Pohl, M., Popkow, A., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Roache, E., Rousselle, J., Rovero, A. C., Saxon, D. B., Sembroski, G. H., Shahinyan, K., Sheidaei, F., Skole, C., Smith, A. W., Staszak, D., Telezhinsky, I., Theiling, M., Todd, N. W., Tucci, J. V., Tyler, J., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., Zitzer, B., Baring, M. G., Gónzalez, J. Becerra, Cillis, A. N., Horan, D., and Paneque, D.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The very high energy (VHE; E $>$ 100 GeV) blazar Markarian 501 was observed between April 17 and May 5 (MJD 54938--54956), 2009, as part of an extensive multi-wavelength campaign from radio to VHE. Strong VHE $\gamma$-ray activity was detected on May 1st with Whipple and VERITAS, when the flux (E $>$ 400 GeV) increased to 10 times the pre-flare baseline flux ($3.9{\times 10^{-11}}~{\rm ph~cm^{-2}~s^{-1}}$), reaching five times the flux of the Crab Nebula. This coincided with a decrease in the optical polarization and a rotation of the polarization angle by 15$^{\circ}$. This VHE flare showed a fast flux variation with an increase of a factor $\sim$4 in 25 minutes, and a falling time of $\sim$50 minutes. We present the observations of the quiescent state previous to the flare and of the high state after the flare, focusing on the flux and spectral variability from Whipple, VERITAS, Fermi-LAT, RXTE, and Swift combined with optical and radio data., Comment: 13 pages, 10 figures. Accepted for publication in Astronomy and Astrophysics
Published: 2016
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8. Upper limits from five years of blazar observations with the VERITAS Cherenkov telescopes

Author: Archambault, S., Archer, A., Benbow, W., Bird, R., Biteau, J., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Eisch, J. D., Errando, M., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Hütten, M., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nguyen, T., Nieto, D., De Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Park, N., Perkins, J. S., Pichel, A., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Williams, D. A., Zitzer, B., Fumagalli, M., and Prochaska, J. X.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Between the beginning of its full-scale scientific operations in 2007 and 2012, the VERITAS Cherenkov telescope array observed more than 130 blazars; of these, 26 were detected as very-high-energy (VHE; E>100 GeV) {\gamma}-ray sources. In this work, we present the analysis results of a sample of 114 undetected objects. The observations constitute a total live-time of ~570 hours. The sample includes several unidentified Fermi-Large Area Telescope (LAT) sources (located at high Galactic latitude) as well as all the sources from the second Fermi-LAT catalog which are contained within the field of view of the VERITAS observations. We have also performed optical spectroscopy measurements in order to estimate the redshift of some of these blazars that do not have a spectroscopic distance estimate. We present new optical spectra from the Kast instrument on the Shane telescope at the Lick observatory for 18 blazars included in this work, which allowed for the successful measurement or constraint on the redshift of four of them. For each of the blazars included in our sample we provide the flux upper limit in the VERITAS energy band. We also study the properties of the significance distributions and we present the result of a stacked analysis of the data-set, which shows a 4 {\sigma} excess., Comment: 22 pages; accepted for publication in The Astronomical Journal
Published: 2016
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9. TeV Gamma-ray Observations of The Galactic Center Ridge By VERITAS

Author: Archer, A., Benbow, W., Bird, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Collins-Hughes, E., Connolly, M. P., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Flinders, A., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Hutten, M., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., Ong, R. A., Park, N., Pelassa, V., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Ratliff, G., Reynolds, P. T., Richards, G. T., Roache, E., Rousselle, J., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Vassiliev, V. V., Wakely, S. P., Weiner, O. M., Weinstein, A., Wilhelm, A., Williams, D. A., Zitzer, B., and Yusef-Zadeh, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Galactic Center Ridge has been observed extensively in the past by both GeV and TeV gamma-ray instruments revealing a wealth of structure, including a diffuse component as well as the point sources G0.9+0.1 (a composite supernova remnant) and Sgr A* (believed to be associated with the supermassive black hole located at the center of our Galaxy). Previous very high energy (VHE) gamma-ray observations with the H.E.S.S. experiment have also detected an extended TeV gamma-ray component along the Galactic plane in the >300 GeV gamma-ray regime. Here we report on observations of the Galactic Center Ridge from 2010-2014 by the VERITAS telescope array in the >2 TeV energy range. From these observations we 1.) provide improved measurements of the differential energy spectrum for Sgr A* in the >2 TeV gamma-ray regime, 2.) provide a detection in the >2 TeV gamma-ray emission from the composite SNR G0.9+0.1 and an improved determination of its multi-TeV gamma-ray energy spectrum, 3.) report on the detection of VER J1746-289, a localized enhancement of >2 TeV gamma-ray emission along the Galactic plane., Comment: 9 pages, 5 figures, Accepted for Publication in The Astrophysical Journal
Published: 2016
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10. A Search for Brief Optical Flashes Associated with the SETI Target KIC 8462852

Author: Abeysekara, A. U., Archambault, S., Archer, A., Benbow, W., Bird, R., Buchovecky, M., Buckley, J. H., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Christiansen, J. L., Ciupik, L., Cui, W., Dickinson, H. J., Eisch, J. D., Errando, M., Falcone, A., Fegan, D. J., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Huetten, M., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Lin, T. T. Y., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nieto, D., O'Brien, S., de Bhroithe, A. O'Faolain, Ong, R. A., Otte, A. N., Park, N., Perkins, J. S., Petrashyk, A., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Ratliff, G., Reynolds, P. T., Richards, G. T., Roache, E., Santander, M., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Williams, D. A., and Zitzer, B.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: The F-type star KIC 8462852 has recently been identified as an exceptional target for SETI (search for extraterrestrial intelligence) observations. We describe an analysis methodology for optical SETI, which we have used to analyse nine hours of serendipitous archival observations of KIC 8462852 made with the VERITAS gamma-ray observatory between 2009 and 2015. No evidence of pulsed optical beacons, above a pulse intensity at the Earth of approximately 1 photon per m^2, is found. We also discuss the potential use of imaging atmospheric Cherenkov telescope arrays in searching for extremely short duration optical transients in general., Comment: Accepted for publication in ApJ Letters. Fixed a minor error in the title
Published: 2016
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11. Exceptionally bright TeV flares from the binary LS I +61$^\circ$ 303

Author: VERITAS Collaboration, Archambault, S., Archer, A., Aune, T., Barnacka, A., Benbow, W., Bird, R., Buchovecky, M., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V., Cerruti, M., Chen, X., Ciupik, L., Collins-Hughes, E., Connolly, M. P., Cui, W., Dickinson, H. J., Dumm, J., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Flinders, A., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Huetten, M., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Kertzman, M., Khassen, Y., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., O'Brien, S., de Bhroithe, A. O'Faolain, Ong, R. A., Otte, A. N., Pandel, D., Park, N., Pelassa, V., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rousselle, J., Rulten, C., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Wilhelm, A., Williams, D. A., and Zitzer, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The TeV binary system LS I +61$^\circ$ 303 is known for its regular, non-thermal emission pattern which traces the orbital period of the compact object in its 26.5 day orbit around its B0 Ve star companion. The system typically presents elevated TeV emission around apastron passage with flux levels between 5% and 15% of the steady flux from the Crab Nebula (> 300 GeV). In this article, VERITAS observations of LS I +61$^\circ$ 303 taken in late 2014 are presented, during which bright TeV flares around apastron at flux levels peaking above 30% of the Crab Nebula flux were detected. This is the brightest such activity from this source ever seen in the TeV regime. The strong outbursts have rise and fall times of less than a day. The short timescale of the flares, in conjunction with the observation of 10 TeV photons from LS I +61$^\circ$ 303 during the flares, provides constraints on the properties of the accelerator in the source., Comment: 9 pages, 2 figures. Accepted for publication by ApJL
Published: 2016
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12. Gamma rays from the quasar PKS 1441+25: story of an escape

Author: Abeysekara, A. U., Archambault, S., Archer, A., Aune, T., Barnacka, A., Benbow, W., Bird, R., Biteau, J., Buckley, J. H., Bugaev, V., Cardenzana, J. V, Cerruti, M., Chen, X., Christiansen, J. L., Ciupik, L., Connolly, M. P., Coppi, P., Cui, W., Dickinson, H. J., Dumm, J., Eisch, J. D., Errando, M., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Flinders, A., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Grube, J., Gyuk, G., Hütten, M., Håkansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kelley-Hoskins, N., Khassen, Y., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Park, N., Perkins, J. S., Petrashyk, A., Pohl, M., Popkow, A., Pueschel, E., Quinn, J., Ragan, K., Ratliff, G., Reynolds, P. T., Richards, G. T., Roache, E., Rousselle, J., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Todd, N. W., Tucci, J. V., Tyler, J., Vassiliev, V. V., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Wilhelm, A., Williams, D. A., Zitzer, B., Smith, P. S., Holoien, T. W. -S., Prieto, J. L., Kochanek, C. S., Stanek, K. Z., Shappee, B., Hovatta, T., Max-Moerbeck, W., Pearson, T. J., Reeves, R. A., Richards, J. L., Readhead, A. C. S., Madejski, G. M., Djorgovski, S. G., Drake, A. J., Graham, M. J., and Mahabal, A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Outbursts from gamma-ray quasars provide insights on the relativistic jets of active galactic nuclei and constraints on the diffuse radiation fields that fill the Universe. The detection of significant emission above 100 GeV from a distant quasar would show that some of the radiated gamma rays escape pair-production interactions with low-energy photons, be it the extragalactic background light (EBL), or the radiation near the supermassive black hole lying at the jet's base. VERITAS detected gamma-ray emission up to 200 GeV from PKS 1441+25 (z=0.939) during April 2015, a period of high activity across all wavelengths. This observation of PKS 1441+25 suggests that the emission region is located thousands of Schwarzschild radii away from the black hole. The gamma-ray detection also sets a stringent upper limit on the near-ultraviolet to near-infrared EBL intensity, suggesting that galaxy surveys have resolved most, if not all, of the sources of the EBL at these wavelengths., Comment: 7 pages, 3 figures, published in ApJ Letters 815, L22 (2015)
Published: 2015
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13. CTA Contributions to the 34th International Cosmic Ray Conference (ICRC2015)

Author: Consortium, The CTA, Abchiche, A., Abeysekara, U., Abril, Ó., Acero, F., Acharya, B. S., Actis, M., Agnetta, G., Aguilar, J. A., Aharonian, F., Akhperjanian, A., Albert, A., Alcubierre, M., Alfaro, R., Aliu, E., Allafort, A. J., Allan, D., Allekotte, I., Aloisio, R., Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonucci, M., Antonuccio, V., Antoranz, P., Aramo, C., Aravantinos, A., Argan, A., Armstrong, T., Arnaldi, H., Arnold, L., Arrabito, L., Arrieta, M., Asano, K., Asorey, H. G., Aune, T., Singh, C. B., Babic, A., Backes, M., Bais, A., Bajtlik, S., Balazs, C., Balbo, M., Balis, D., Balkowski, C., Ballester, O., Ballet, J., Balzer, A., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., de Almeida, U. Barres, Barrio, J. A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becciani, U., Becherini, Y., Tjus, J. Becker, Beckmann, V., Bednarek, W., Benbow, W., Ventura, D. Benedico, Berdugo, J., Berge, D., Bernardini, E., Bernhard, S., Bernlöhr, K., Bertucci, B., Besel, M. -A., Bhatt, N., Bhattacharjee, P., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Billotta, S., Bilnik, W., Biondo, B., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Bigas, O. Blanch, Blasi, P., Boehm, C., Bogacz, L., Bogdan, M., Bohacova, M., Boisson, C., Gargallo, J. Boix, Bolmont, J., Bonanno, G., Bonardi, A., Bonifacio, P., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Bottani, A., Böttcher, M., Bousquet, J. -J., Boutonnet, C., Bouyjou, F., Braiding, C., Brandt, L., Brau-Nogué, S., Bregeon, J., Bretz, T., Briggs, M., Brigida, M., Bringmann, T., Brisken, W., Brocato, E., Brook, P., Brown, A. M., Brun, P., Brunetti, G., Brunetti, L., Bruno, P., Bryan, M., Buanes, T., Bucciantini, N., Buchholtz, G., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Cameron, R., Camprecios, J., Canelli, F., Canestrari, R., Cantu, S., Capalbi, M., Capasso, M., Capobianco, G., Caraveo, P., Cardenzana, J., Carius, S., Carlile, C., Carmona, E., Carosi, A., Carosi, R., Carr, J., Carroll, M., Carter, J., Carton, P. -H., Caruso, R., Casandjian, J. -M., Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Catalano, O., Catalanotti, S., Cavazzani, S., Cazaux, S., Cefalà, M., Cerchiara, P., Cereda, M., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chaty, S., Chaves, R., Cheimets, P., Chen, A., Chen, X., Chernyakova, M., Chiappetti, L., Chikawa, M., Chinn, D., Chitnis, V. R., Cho, N., Christov, A., Chudoba, J., Cieślar, M., Cillis, A., Ciocci, M. A., Clay, R., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Compin, M., Conforti, V., Connaughton, V., Connell, S., Conrad, J., Contreras, J. L., Coppi, P., Corbel, S., Coridian, J., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Crimi, G., Criswell, S. J., Crocker, R., Croston, J., Cusumano, G., Da Vela, P., Dale, Ø., D'Ammando, F., Dang, D., Daniel, M., Davids, I., Dawson, B., Dazzi, F., Costa, B. de Aguiar, De Angelis, A., Cardoso, R. F. de Araujo, De Caprio, V., De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De La Vega, G. A., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Decock, G., Deil, C., Del Santo, M., Delagnes, E., Deleglise, G., Delgado, C., della Volpe, D., Deloye, P., Depaola, G., Detournay, M., Dettlaff, A., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., Di Sciascio, G., Díaz, C., Dick, J., Dickinson, H., Diebold, S., Diez, V., Digel, S., Dipold, J., Disset, G., Distefano, A., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominik, N., Prester, D. Dominis, Donat, A., Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Doyle, K., Drake, G., Dravins, D., Drury, L., Dubus, G., Dumas, D., Dumm, J., Durand, D., D'Urso, D., Dwarkadas, V., Dyks, J., Dyrda, M., Ebr, J., Echaniz, J. C., Edy, E., Egberts, K., Eger, P., Einecke, S., Eisch, J., Eisenkolb, F., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Engelbrecht, C., Engelhaupt, D., Ernenwein, J. -P., Errando, M., Eschbach, S., Etchegoyen, A., Evans, P., Fairbairn, M., Falcone, A., Fantinel, D., Farakos, K., Farnier, C., Farrell, E., Farrell, S., Fasola, G., Fegan, S., Feinstein, F., Ferenc, D., Fernandez, A., Fernandez-Alonso, M., Ferreira, O., Fesquet, M., Fetfatzis, P., Fiasson, A., Filipčič, A., Filipovic, M., Fink, D., Finley, C., Finley, J. P., Finoguenov, A., Fioretti, V., Fiorini, M., Curcoll, R. Firpo, Fleischhack, H., Flores, H., Florin, D., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fontes, B., Forest, F., Fornasa, M., Förster, A., Fortin, P., Fortson, L., Fouque, N., Franckowiak, A., Franco, F. J., Frankowski, A., Frega, N., Albuquerque, I. Freire Mota, Coromina, L. Freixas, Fresnillo, L., Fruck, C., Fuessling, M., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukuda, T., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gadola, A., Galante, N., Gall, D. D., Gallant, Y., Galloway, D., Gallozzi, S., Gao, S., Garcia, B., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, C., Gargano, F., Garozzo, S., Garrecht, F., Garrido, D., Garrido, L., Gascon, D., Gaskins, J., Gaudemard, J., Gaug, M., Gaweda, J., Geffroy, N., Gérard, L., Ghalumyan, A., Ghedina, A., Ghigo, M., Ghislain, P., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giomi, M., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Giuliani, A., Glicenstein, J. -F., Godinovic, N., Goldoni, P., Berisso, M. Gomez, Vargas, G. A. Gomez, Gonzalez, M. M., González, A., González, F., Muñoz, A. González, Gothe, K. S., Gotz, D., Grabarczyk, T., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Green, A. M., Greenshaw, T., Grenier, I., Grillo, A., Grondin, M. -H., Grube, J., Grudzinska, M., Grygorczuk, J., Guarino, V., Guberman, D., Gunji, S., Gyuk, G., Hadasch, D., Hagedorn, A., Hahn, J., Hakansson, N., Heras, N. Hamer, Hanabata, Y., Hara, S., Hardcastle, M. J., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hirai, W., Hirotani, K., Hoard, D., Hoffmann, D., Hofmann, W., Hofverberg, P., Holch, T., Holder, J., Hooper, S., Horan, D., Hörandel, J. R., Hormigos, S., Horns, D., Hose, J., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hütten, M., Humensky, T. B., Huovelin, J., Huppert, J. -F., Iacovacci, M., Ibarra, A., Idźkowski, B., Ikawa, D., Illa, J. M., Impiombato, D., Incorvaia, S., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Iori, M., Ishio, K., Israel, G. L., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Janiak, M., Jankowsky, F., Jean, P., Jeanney, C., Jegouzo, I., Jenke, P., Jimenez, J. J., Jingo, M., Jocou, L., Jogler, T., Johnson, C. A., Journet, L., Juffroy, C., Jung, I., Kaaret, P. E., Kagaya, M., Kakuwa, J., Kalekin, O., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Karn, P., Kasperek, J., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kaufmann, S., Kawanaka, N., Kawashima, T., Kazanas, D., Kelley-Hoskins, N., Kellner-Leidel, B., Kendziorra, E., Kersten, J., Khélifi, B., Kieda, D. B., Kihm, T., Kisaka, S., Kissmann, R., Klepser, S., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodakkadan, A., Kodani, K., Kohri, K., Kojima, T., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Kosack, K., Koss, G., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Kraus, M., Krause, J., Krause, M., Krawzcynski, H., Krennrich, F., Kretzschmann, A., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Laffon, H., Lagadec, T., Lahmann, R., Lalik, K., Lamanna, G., Landriu, D., Landt, H., Lang, R. G., Languignon, D., Lapington, J., Laporte, P., Latovski, N., Law-Green, D., Fèvre, J. -P. Le, Flour, T. Le, Sidaner, P. Le, Lee, S. -H., Lee, W. H., Leffhalm, K., Leich, H., de Oliveira, M. A. Leigui, Lelas, D., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leonard, R., Leoni, R., Lessio, L., Leto, G., Leveque, A., Lieunard, B., Limon, M., Lindemann, R., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Loiseau, D., Łokas, E., Lombardi, S., Longo, F., Longo, G., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Loreggia, D., Louge, T., Louis, F., Lu, C. -C., Lucarelli, F., Lucchesi, D., Lüdecke, H., Luque-Escamilla, P. L., Luz, O., Lyard, E., Maccarone, M. C., Maccarone, T. J., Mach, E., Madejski, G. M., Madonna, A., Mahabir, M., Maier, G., Majumdar, P., Makariev, M., Malaguti, G., Malaspina, G., Mallot, A. K., Maltezos, S., Mancilla, A., Mandat, D., Maneva, G., Manigot, P., Mankushiyil, N., Mannheim, K., Maragos, N., Marano, D., Marchegiani, P., Marcomini, J. 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Moralejo, Morello, C., Moretti, E., Mori, K., Morlino, G., Morselli, A., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mueller, S., Mukherjee, R., Munar-Adrover, P., Mundell, C., Muraishi, H., Murase, K., Muronga, A., Murphy, A., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, D., Nayman, P., Nellen, L., Nemmen, R., Neronov, A., Neustroev, V., Neyroud, N., Nguyen, T., Nicastro, L., Nicolau-Kukliński, J., Niederwanger, F., Niedźwiecki, A., Niemiec, J., Nieto, D., Nievas, M., Nikolaidis, A., Nishijima, K., Nishikawa, K. -I., Noda, K., Nogues, L., Nolan, S., Northrop, R., Nosek, D., Nozka, L., Nunio, F., Oakes, L., O'Brien, P., Occhipinti, G., de Bhroithe, A. O'Faolain, Ogino, M., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okumura, A., Olive, J. -F., Olszowski, D., Ong, R. A., Ono, S., Orienti, M., Orito, R., Orlati, A., Osborne, J., Ostrowski, M., Otero, L. A., Ottaway, D., Otte, N., Oya, I., Ozieblo, A., Padovani, M., Pagano, I., Paiano, S., Paizis, A., Palacio, J., Palatka, M., Pallotta, J., Panagiotidis, K., Panazol, J. -L., Paneque, D., Panter, M., Panzera, M. R., Paoletti, R., Paolillo, M., Papayannis, A., Papyan, G., Paravac, A., Paredes, J. M., Pareschi, G., Park, N., Parsons, D., Paśko, P., Pavy, S., Arribas, M. Paz, Pech, M., Peck, A., Pedaletti, G., Peet, S., Pelassa, V., Pelat, D., Peres, C., Perez, M. d. C., Perri, L., Persic, M., Petrashyk, A., Petrucci, P. -O., Peyaud, B., Pfeifer, M., Pfeiffer, G., Piano, G., Pichel, A., Pieloth, D., Pierbattista, M., Pierre, E., de Pinho, F. Pinto, García, C. Pio, Piret, Y., Pita, S., Planes, A., Platino, M., Platos, Ł., Platzer, R., Podkladkin, S., Pogosyan, L., Pohl, M., Poinsignon, P., Ponz, J. D., Porcelli, A., Potter, W., Poulios, S., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokhorov, D., Prokoph, H., Prouza, M., Proyetti, M., Pruchniewicz, R., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Queiroz, F., Quel, E. J., Quinn, J., Quirrenbach, A., Racero, E., Räck, T., Rafalski, J., Rafighi, I., Rainò, S., Rajda, P. J., Rameez, M., Rando, R., Rannot, R. C., Rataj, M., Rateau, S., Ravel, T., Ravignani, D., Razzaque, S., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reposeur, T., Rettig, R., Reville, B., Rhode, W., Ribeiro, D., Ribó, M., Richards, G., Richer, M. G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ristori, P. R., Rivière, A., Rivoire, S., Roache, E., Rodeghiero, G., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rogers, T., Rojas, G., Romano, P., Rodriguez, M. P. Romay, Romeo, G., Romero, G. E., Roncadelli, M., Rose, J., Rosen, S., Lees, S. Rosier, Ross, D., Rossiter, P., Rouaix, G., Rousselle, J., Rovero, A. C., Rowell, G., Roy, F., Royer, S., Różańska, A., Rudak, B., Rugliancich, A., Rulten, C., Rupiński, M., Russo, F., Rutkowski, K., Saavedra, O., Sabatini, S., Sacco, B., Saemann, E. O., Saggion, A., Saha, L., Sahakian, V., Saito, K., Saito, T., Sakaki, N., Salega, M., Salek, D., Salgado, J., Salini, A., Sanchez, D., Sanchez, F., Sanchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Santos-Lima, R., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Savalle, R., Sawada, M., Sayède, F., Schafer, J., Schanne, S., Schanz, T., Schioppa, E. J., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schneider, M., Schovanek, P., Schubert, A., Schultz, C., Schultze, J., Schulz, A., Schulz, S., Schure, K., Schussler, F., Schwab, T., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Schwendicke, U., Schwerdt, C., Segreto, A., Seiradakis, J. -H., Sembroski, G. H., Semikoz, D., Serre, N., Servillat, M., Seweryn, K., Shafi, N., Sharma, M., Shayduk, M., Shellard, R. C., Shibata, T., Pandeni, K. Shiningayamwe, Shukla, A., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sinha, A., Sironi, G., Sitarek, J., Sizun, P., Slyusar, V., Smith, A., Smith, J., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spengler, G., Spiga, D., Stadler, R., Stahl, O., Stamatescu, V., Stamerra, A., Stanič, S., Starling, R., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stergioulas, N., Sternberger, R., Sterzel, M., Stevenson, B., Stinzing, F., Stodulska, M., Stodulski, M., Stolarczyk, T., Straumann, U., Strazzeri, E., Stringhetti, L., Strzys, M., Stuik, R., Sulanke, K. -H., Supanitsky, A. D., Suric, T., Sushch, I., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szwarnog, P., Tacchini, A., Tachihara, K., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takahashi, M., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tanaka, T., Tanaka, Y., Tanci, C., Tarantino, E., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Telezhinsky, I., Temme, F., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Tescaro, D., Teshima, M., Testa, V., Tezier, D., Thayer, J., Thomas, V., Thornhill, J., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Tijsseling, G., Timpanaro, M. C., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tomastik, J., Tomono, Y., Tonachini, A., Tonev, D., Torii, K., Tornikoski, M., Torres, D. F., Torres, M., Torresi, E., Toscano, S., Toso, G., Tosti, G., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Townsley, C., Toyama, T., Travnicek, P., Trifoglio, M., Pujadas, I. Troyano, Trzeciak, M., Tsinganos, K., Tsubone, Y., Tsuchiya, Y., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Umetsu, Y., Underwood, C., Upadhya, S. S., Uslenghi, M., Vagnetti, F., Valdes-Galicia, J., Vallania, P., Vallejo, G., Valore, L., van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Vasileiadis, G., Vassiliev, V., Acosta, M. L. Vázquez, Vecchi, M., Vegas, I., Veitch, P., Venema, L., Venter, C., Vercellone, S., Vergani, S., Verma, K., Verzi, V., Vettolani, G. P., Viana, A., Vicha, J., Videla, M., Vigorito, C., Vincent, P., Vincent, S., Vink, J., Vittorini, V., Vlahakis, N., Vlahos, L., Voelk, H., Vogler, P., Voisin, V., Vollhardt, A., Volpicelli, A., Vorobiov, S., Vovk, I., Vu, L. V., Wagner, R., Wagner, R. M., Wagner, R. G., Wagner, S. J., Wakely, S. P., Walter, R., Walther, T., Ward, J. E., Ward, M., Warda, K., Warwick, R., Wassberg, S., Watson, J., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Wells, R., Werner, F., Werner, M., Wetteskind, H., White, M., White, R., Więcek, M., Wierzcholska, A., Wiesand, S., Wijers, R., Wild, N., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Williams, J. T., Willingale, R., Winde, M., Winiarski, K., Winkler, H., Wischnewski, R., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, E., Wu, T., Yadav, K. K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yang, L., Yebras, J. M., Yelos, D., Yeung, W., Yoshida, A., Yoshida, T., Yoshiike, S., Yoshikoshi, T., Yu, P., Zabalza, V., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A., Zech, A., Zechlin, H., Zhao, A., Ziegler, A., Ziemann, J., Ziętara, K., Ziółkowski, J., Zitelli, V., Zoli, A., Zurbach, C., and Żychowski, P.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: List of contributions from the CTA Consortium presented at the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands., Comment: Index of CTA conference proceedings at the ICRC2015, The Hague (The Netherlands). v1: placeholder with no arXiv links yet, to be replaced once individual contributions have been all submitted; v2: final with arXiv links to all CTA contributions and full author list
Published: 2015

14. VERITAS detection of $\gamma$-ray flaring activity from the BL Lac object 1ES 1727+502 during bright moonlight observations

Author: Archambault, S., Archer, A., Beilicke, M., Benbow, W., Bird, R., Biteau, J., Bouvier, A., Bugaev, V., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Dickinson, H. J., Dumm, J., Eisch, J. D., Errando, M., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Håkansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Khassen, Y., Kieda, D., Krause, M., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Park, N., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vincent, S., Wakely, S. P., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., Zitzer, B., and Hughes, Z. D.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: During moonlit nights, observations with ground-based Cherenkov telescopes at very high energies (VHE, $E>100$ GeV) are constrained since the photomultiplier tubes (PMTs) in the telescope camera are extremely sensitive to the background moonlight. Observations with the VERITAS telescopes in the standard configuration are performed only with a moon illumination less than 35$\%$ of full moon. Since 2012, the VERITAS collaboration has implemented a new observing mode under bright moonlight, by either reducing the voltage applied to the PMTs (reduced-high-voltage configuration, RHV), or by utilizing UV-transparent filters. While these operating modes result in lower sensitivity and increased energy thresholds, the extension of the available observing time is useful for monitoring variable sources such as blazars and sources requiring spectral measurements at the highest energies. In this paper we report the detection of $\gamma$-ray flaring activity from the BL Lac object 1ES 1727+502 during RHV observations. This detection represents the first evidence of VHE variability from this blazar. The integral flux is $(1.1\pm0.2)\times10^{-11}\mathrm{cm^{-2}s^{-1}}$ above 250 GeV, which is about five times higher than the low-flux state. The detection triggered additional \veritas\ observations during standard dark-time. Multiwavelength observations with the FLWO 48" telescope, and the Swift and Fermi satellites are presented and used to produce the first spectral energy distribution (SED) of this object during $\gamma$-ray flaring activity. The SED is then fitted with a standard synchrotron-self-Compton model, placing constraints on the properties of the emitting region and of the acceleration mechanism at the origin of the relativistic particle population in the jet., Comment: 11 pages, 3 figures, accepted for publication in ApJ
Published: 2015
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15. A Search for Pulsations from Geminga Above 100 GeV with VERITAS

Author: Aliu, E., Archambault, S., Archer, A., Aune, T., Barnacka, A., Beilicke, M., Benbow, W., Bird, R., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Dickinson, H. J., Dumm, J., Eisch, J. D., Errando, M., Falcone, A., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Hakansson, N., Hanna, D., Holder, J., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Krennrich, F., Kumar, S., Lang, M. J., Lyutikov, M., Madhavan, A. S, Maier, G., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., de Bhroithe, A. O'Faolain, Ong, R. A., Otte, A. N., Park, N., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Quinn, J., Ragan, K., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Santander, M., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vincent, S., Wakely, S. P., Weinstein, A., Williams, D. A., Zajczyk, A., and Zitzer, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the results of 71.6 hours of observations of the Geminga pulsar (PSR J0633+1746) with the VERITAS very-high-energy gamma-ray telescope array. Data taken with VERITAS between November 2007 and February 2013 were phase-folded using a Geminga pulsar timing solution derived from data recorded by the XMM-\emph{Newton} and \emph{Fermi}-LAT space telescopes. No significant pulsed emission above 100 GeV is observed, and we report upper limits at the 95% confidence level on the integral flux above 135 GeV (spectral analysis threshold) of 4.0$\times10^{-13}$ s$^{-1}$ cm$^{-2}$ and 1.7$\times10^{-13}$ s$^{-1}$ cm$^{-2}$ for the two principal peaks in the emission profile. These upper limits, placed in context with phase-resolved spectral energy distributions determined from five years of data from the \emph{Fermi}-LAT, constrain possible hardening of the Geminga pulsar emission spectra above $\sim$50 GeV., Comment: 7 pages, 2 figures, 2 tables. Accepted for publication in ApJ
Published: 2014
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16. Unprecedented study of the broadband emission of Mrk 421 during flaring activity in March 2010

Author: The MAGIC Collaboration, Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Boller, A., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Wilhelmi, E. de Oña, Mendez, C. Delgado, Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Godinović, N., Muñoz, A. González, Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hildebrand, D., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., López, M., López-Coto, R., López-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Rügamer, S., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Sun, S., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Steinke, B., Storz, J., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Zanin, R., Collaboration, The VERITAS, Archambault, S., Archer, A., Beilicke, M., Benbow, W., Berger, K., Bird, R., Biteau, J., Buckley, J. H., Bugaev, V., Cerruti, M., Chen, X., Ciupik, L., Collins-Hughes, E., Cui, W., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Gyuk, G., Håkansson, N., Holder, J., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Lang, M. J., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Ong, R. A., Otte, A. N., Perkins, J. S., Pichel, A., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Ragan, K., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Wakely, S. P., Welsing, R., Wilhelm, A., Williams, D. A., Collaborators, External, Buson, S., Finke, J., Villata, M., Raiteri, C., Aller, H. D., Aller, M. F., Cesarini, A., Chen, W. P., Gurwell, M. A., Jorstad, S. G., Kimeridze, G. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Lähteenmäki, A., Larionov, V. M., Larionova, E. G., Lin, H. C., McBreen, B., Moody, J. W., Morozova, D. A., Marscher, A. P., Max-Moerbeck, W., Nikolashvili, M. G., Perri, M., Readhead, A. C. S., Richards, J. L., Ros, J. A., Sadun, A. C., Sakamoto, T., Sigua, L. A., Smith, P. S., Tornikoski, M., Troitsky, I. S., Wehrle, A. E., and Jordan, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: A flare from the TeV blazar Mrk 421, occurring in March 2010, was observed for 13 consecutive days from radio to very high energy (VHE, E > 100 GeV) gamma-rays with MAGIC, VERITAS, Whipple, FermiLAT, MAXI, RXTE, Swift, GASP-WEBT, and several optical and radio telescopes. We model the day-scale SEDs with one-zone and two-zone synchrotron self-Compton (SSC) models, investigate the physical parameters, and evaluate whether the observed broadband SED variability can be associated to variations in the relativistic particle population. Flux variability was remarkable in the X-ray and VHE bands while it was minor or not significant in the other bands. The one-zone SSC model can describe reasonably well the SED of each day for the 13 consecutive days. This flaring activity is also very well described by a two-zone SSC model, where one zone is responsible for the quiescent emission while the other smaller zone, which is spatially separated from the first one, contributes to the daily-variable emission occurring in X-rays and VHE gamma-rays. Both the one-zone SSC and the two-zone SSC models can describe the daily SEDs via the variation of only four or five model parameters, under the hypothesis that the variability is associated mostly to the underlying particle population. This shows that the particle acceleration and cooling mechanism producing the radiating particles could be the main one responsible for the broadband SED variations during the flaring episodes in blazars. The two-zone SSC model provides a better agreement to the observed SED at the narrow peaks of the low- and high-energy bumps during the highest activity, although the reported one-zone SSC model could be further improved by the variation of the parameters related to the emitting region itself ($\delta$, $B$ and $R$), in addition to the parameters related to the particle population., Comment: Published in A&A, 30 pages, 15 figures, 6 tables. Online-data: multi-wavelength light curves (data in Fig. 1) and broadband spectral energy distributions (the data in Figs. 6, and B1-B4) are available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/A22. Corresponding authors: David Paneque (dpaneque@mpp.mpg.de), Shangyu Sun (sysun@mpp.mpg.de), Hajime Takami (takami@post.kek.jp)
Published: 2014
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17. Investigating Broadband Variability of the TeV Blazar 1ES 1959+650

Author: Aliu, E., Archambault, S., Arlen, T., Aune, T., Barnacka, A., Beilicke, M., Benbow, W., Berger, K., Bird, R., Bouvier, A., Buckley, J. H., Bugaev, V., Cerruti, M., Chen, X., Ciupik, L., Collins-Hughes, E., Connolly, M. P., Cui, W., Dumm, J., Eisch, J. D., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Hakansson, N., Hanna, D., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Khassen, Y., Kieda, D., Krawczynski, H., Krennrich, F., Lang, M. J., Madhavan, A. S, Majumdar, P., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nelson, T., Nieto, D., de Bhroithe, A. O'Faolain, Ong, R. A., Otte, A. N., Park, N., Perkins, J. S., Pohl, M., Popkow, A., Prokoph, H., Quinn, J., Ragan, K., Rajotte, J., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Sadun, A., Santander, M., Sembroski, G. H., Shahinyan, K., Sheidaei, F., Smith, A. W., Staszak, D., Telezhinsky, I., Theiling, M., Tyler, J., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Weekes, T. C., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., Zitzer, B., Böttcher, M., and Fumagalli, M.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We summarize broadband observations of the TeV-emitting blazar 1ES 1959+650, including optical R-band observations by the robotic telescopes Super-LOTIS and iTelescope, UV observations by Swift UVOT, X-ray observations by the Swift X-ray Telescope (XRT), high-energy gamma-ray observations with the Fermi Large Area Telescope (LAT) and very-high-energy (VHE) gamma-ray observations by VERITAS above 315 GeV, all taken between 17 April 2012 and 1 June 2012 (MJD 56034 and 56079). The contemporaneous variability of the broadband spectral energy distribution is explored in the context of a simple synchrotron self Compton (SSC) model. In the SSC emission scenario, we find that the parameters required to represent the high state are significantly different than those in the low state. Motivated by possible evidence of gas in the vicinity of the blazar, we also investigate a reflected-emission model to describe the observed variability pattern. This model assumes that the non-thermal emission from the jet is reflected by a nearby cloud of gas, allowing the reflected emission to re-enter the blob and produce an elevated gamma-ray state with no simultaneous elevated synchrotron flux. The model applied here, although not required to explain the observed variability pattern, represents one possible scenario which can describe the observations. As applied to an elevated VHE state of 66% of the Crab Nebula flux, observed on a single night during the observation period, the reflected-emission scenario does not support a purely leptonic non-thermal emission mechanism. The reflected emission model does, however, predict a reflected photon field with sufficient energy to enable elevated gamma-ray emission via pion production with protons of energies between 10 and 100 TeV., Comment: Accepted by ApJ
Published: 2014
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18. VERITAS Observations of the BL Lac Object PG 1553+113

Author: Aliu, E., Archer, A., Aune, T., Barnacka, A., Behera, B., Beilicke, M., Benbow, W., Berger, K., Bird, R., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connolly, M. P., Cui, W., Dickinson, H. J., Dumm, J., Eisch, J. D., Errando, M., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Håkansson, N., Hanna, D., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kertzman, P. Kar M., Khassen, Y., Kieda, D., Krawczynski, H., Krennrich, F., Kumar, S., Lang, M. J., Madhavan, A., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Orr, M., Otte, A. N., Park, N., Perkins, J. S., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Quinn, J., Ragan, K., Rajotte, J., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vassiliev, V. V., Wakely, S. P., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., and Zitzer, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present results from VERITAS observations of the BL Lac object PG 1553+113 spanning the years 2010, 2011, and 2012. The time-averaged spectrum, measured between 160 and 560\,GeV, is well described by a power law with a spectral index of $4.33 \pm 0.09$. The time-averaged integral flux above $200\,$GeV measured for this period was $(1.69 \pm 0.06) \times 10^{-11} \, \mathrm{ph} \, \mathrm{cm}^{-2} \, \mathrm{s}^{-1}$, corresponding to 6.9\% of the Crab Nebula flux. We also present the combined $\gamma$-ray spectrum from the Fermi Large Area Telescope and VERITAS covering an energy range from 100~MeV to 560~GeV. The data are well fit by a power law with an exponential cutoff at $\rm {101.9 \pm 3.2 \, \mathrm{GeV}} $. The origin of the cutoff could be intrinsic to PG~1553+113 or be due to the $\gamma$-ray opacity of our universe through pair production off the extragalactic background light (EBL). Given lower limits to the redshift of $\rm z \negthinspace > \negthinspace 0.395$ based on optical/UV observations of PG~1553+113, the cutoff would be dominated by EBL absorption. Conversely, the small statistical uncertainties of the VERITAS energy spectrum have allowed us to provide a robust upper limit on the redshift of PG 1553+113 of $z \negthinspace \leq \negthinspace 0.62$. A strongly-elevated mean flux of $(2.50 \pm 0.14) \times 10^{-11} \, \mathrm{ph} \, \mathrm{cm}^{-2} \, \mathrm{s}^{-1}$ (10.3\% of the Crab Nebula flux) was observed during 2012, with the daily flux reaching as high as $(4.44 \pm 0.71) \times 10^{-11} \, \mathrm{ph} \, \mathrm{cm}^{-2} \, \mathrm{s}^{-1}$ (18.3\% of the Crab Nebula flux) on MJD 56048. The light curve measured during the 2012 observing season is marginally inconsistent with a steady flux, giving a $\chi^2$ probability for a steady flux of 0.03\%., Comment: in press in ApJ, 2014
Published: 2014
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19. The most powerful flaring activity from the NLSy1 PMN J0948+0022

Author: D'Ammando, F., Orienti, M., Finke, J., Raiteri, C. M., Hovatta, T., Larsson, J., Max-Moerbeck, W., Perkins, J., Readhead, A. C. S., Richards, J. L., Beilicke, M., Benbow, W., Berger, K., Bird, R., Bugaev, V., Cardenzana, J. V., Cerruti, M., Chen, X., Ciupik, L., Dickinson, H. J., Eisch, J. D., Errando, M., Falcone, A., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Gerard, L., Gillanders, G. H., Griffiths, S. T., Grube, J., Gyuk, G., Hakansson, N., Holder, J., Humensky, T. B., Kar, P., Kertzman, M., Khassen, Y., Kieda, D., Krennrich, F., Kumar, S., Lang, M. J., Maier, G., McCann, A., Meagher, K., Moriarty, P., Mukherjee, R., Nieto, D., de Bhroithe, A. O' Faolain, Ong, R. A., Otte, A. N., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Richards, G. T., Roache, E., Rousselle, J., Santander, M., Sembroski, G. H., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vassiliev, V. V., Wakely, S. P., Weinstein, A., Welsing, R., Williams, D. A., and Zitzer, B.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on multifrequency observations performed during 2012 December-2013 August of the first narrow-line Seyfert 1 galaxy detected in gamma rays, PMN J0948+0022 ($z$ = 0.5846). A gamma-ray flare was observed by the Large Area Telescope on board Fermi during 2012 December-2013 January, reaching a daily peak flux in the 0.1-100 GeV energy range of (155 $\pm$ 31) $\times$10$^{-8}$ ph cm$^{-2}$ s$^{-1}$ on 2013 January 1, corresponding to an apparent isotropic luminosity of about 1.5$\times$10$^{48}$ erg s$^{-1}$. The gamma-ray flaring period triggered Swift and VERITAS observations in addition to radio and optical monitoring by OVRO, MOJAVE, and CRTS. A strong flare was observed in optical, UV, and X-rays on 2012 December 30, quasi-simultaneously to the gamma-ray flare, reaching a record flux for this source from optical to gamma rays. VERITAS observations at very high energy (E > 100 GeV) during 2013 January 6-17 resulted in an upper limit of F (> 0.2 TeV) < 4.0$\times$10$^{-12}$ ph cm$^{-2}$ s$^{-1}$. We compared the spectral energy distribution (SED) of the flaring state in 2013 January with that of an intermediate state observed in 2011. The two SEDs, modelled as synchrotron emission and an external Compton scattering of seed photons from a dust torus, can be modelled by changing both the electron distribution parameters and the magnetic field., Comment: 13 pages, 5 Figures, 5 Tables. Accepted for publication in Monthly Notices of the Royal Astronomical Society
Published: 2014
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20. Constraints on Very High Energy Emission from GRB 130427A

Author: Aliu, E., Aune, T., Barnacka, A., Beilicke, M., Benbow, W., Berger, K., Biteau, J., Buckley, J. H., Bugaev, V., Byrum, K., Cardenzana, J. V, Cerruti, M., Chen, X., Ciupik, L., Connaughton, V., Cui, W., Dickinson, H. J., Eisch, J. D., Errando, M., Falcone, A., Federici, S., Feng, Q., Finley, J. P., Fleischhack, H., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Griffiths, S. T., Grube, J., Gyuk, G., Håkansson, N., Hanna, D., Holder, J., Hughes, G., Humensky, T. B., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Khassen, Y., Kieda, D., Krawczynski, H., Krennrich, F., Lang, M. J., Madhavan, A. S., Maier, G., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Mukherjee, R., Nieto, D., de Bhróithe, A. O'Faoláin, Ong, R. A., Otte, A. N., Park, N., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Quinn, J., Ragan, K., Rajotte, J., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Sembroski, G. H., Shahinyan, K., Smith, A. W., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Vassiliev, V. V., Vincent, S., Wakely, S. P., Weiner, O. M., Weinstein, A., Welsing, R., Wilhelm, A., Williams, D. A., Zitzer, B., McEnery, J. E., Perkins, J. S., Veres, P., and Zhu, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Prompt emission from the very fluent and nearby (z=0.34) gamma-ray burst GRB 130427A was detected by several orbiting telescopes and by ground-based, wide-field-of-view optical transient monitors. Apart from the intensity and proximity of this GRB, it is exceptional due to the extremely long-lived high-energy (100 MeV to 100 GeV) gamma-ray emission, which was detected by the Large Area Telescope on the Fermi Gamma-ray Space Telescope for ~70 ks after the initial burst. The persistent, hard-spectrum, high-energy emission suggests that the highest-energy gamma rays may have been produced via synchrotron self-Compton processes though there is also evidence that the high-energy emission may instead be an extension of the synchrotron spectrum. VERITAS, a ground-based imaging atmospheric Cherenkov telescope array, began follow-up observations of GRB 130427A ~71 ks (~20 hr) after the onset of the burst. The GRB was not detected with VERITAS; however, the high elevation of the observations, coupled with the low redshift of the GRB, make VERITAS a very sensitive probe of the emission from GRB 130427A for E > 100 GeV. The non-detection and consequent upper limit derived place constraints on the synchrotron self-Compton model of high-energy gamma-ray emission from this burst., Comment: 22 pages, 4 figures, 1 table
Published: 2014
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21. CTA contributions to the 33rd International Cosmic Ray Conference (ICRC2013)

Author: Consortium, The CTA, Abril, O., Acharya, B. S., Actis, M., Agnetta, G., Aguilar, J. A., Aharonian, F., Ajello, M., Akhperjanian, A., Alcubierre, M., Aleksic, J., Alfaro, R., Aliu, E., Allafort, A. J., Allan, D., Allekotte, I., Aloisio, R., Amato, E., Ambrosi, G., Ambrosio, M., Anderson, J., Angüner, E. O., Antonelli, L. A., Antonuccio, V., Antonucci, M., Antoranz, P., Aravantinos, A., Argan, A., Arlen, T., Aramo, C., Armstrong, T., Arnaldi, H., Arrabito, L., Asano, K., Ashton, T., Asorey, H. G., Aune, T., Awane, Y., Baba, H., Babic, A., Baby, N., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balbo, M., Balis, D., Balkowski, C., Ballet, J., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., de Almeida, U. Barres, Barrio, J. A., Basili, A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becciani, U., Becerra, J., Becherini, Y., Bechtol, K. C., Tjus, J. Becker, Beckmann, V., Bednarek, W., Behera, B., Belluso, M., Benbow, W., Berdugo, J., Berge, D., Berger, K., Bernard, F., Bernardino, T., Bernlöhr, K., Bertucci, B., Bhat, N., Bhattacharyya, S., Biasuzzi, B., Bigongiari, C., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Blake, S., Bigas, O. Blanch, Blasi, P., Bobkov, A., Boccone, V., Böttcher, M., Bogacz, L., Bogart, J., Bogdan, M., Boisson, C., Gargallo, J. Boix, Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Bonifacio, P., Bonnoli, G., Bordas, P., Borgland, A., Borkowski, J., Bose, R., Botner, O., Bottani, A., Bouchet, L., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau-Nogué, S., Braun, I., Bretz, T., Briggs, M., Brigida, M., Bringmann, T., Britto, R., Brook, P., Brun, P., Brunetti, L., Bruno, P., Bucciantini, N., Buanes, T., Buckley, J., Bühler, R., Bugaev, V., Bulgarelli, A., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Camprecios, J., Canestrari, R., Cantu, S., Capalbi, M., Caraveo, P., Carmona, E., Carosi, A., Carosi, R., Carr, J., Carter, J., Carton, P. -H., Caruso, R., Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Catalano, O., Cavazzani, S., Cazaux, S., Cerchiara, P., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chaves, R., Cheimets, P., Chen, A., Chiang, J., Chiappetti, L., Chikawa, M., Chitnis, V. R., Chollet, F., Christof, A., Chudoba, J., Cieślar, M., Cillis, A., Cilmo, M., Codino, A., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colome, J., Colonges, S., Compin, M., Conconi, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Coppi, P., Coridian, J., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Crimi, G., Criswell, S. J., Croston, J., Cusumano, G., Dafonseca, M., Dale, O., Daniel, M., Darling, J., Davids, I., Dazzi, F., de Angelis, A., De Caprio, V., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De La Vega, G. A., Lopez, R. de los Reyes, de Lotto, B., De Luca, A., de Naurois, M., de Oliveira, Y., Wilhelmi, E. de Oña, de Palma, F., de Souza, V., Decerprit, G., Decock, G., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., della Volpe, D., Demange, P., Depaola, G., Dettlaff, A., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., di Sciascio, G., Díaz, C., Dick, J., Dickherber, R., Dickinson, H., Diez-Blanco, V., Digel, S., Dimitrov, D., Disset, G., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Prester, D. Dominis, Donat, A., Dorner, D., Doro, M., Dournaux, J. -L., Drake, G., Dravins, D., Drury, L., Dubois, F., Dubois, R., Dubus, G., Dufour, C., Dumas, D., Dumm, J., Durand, D., Dwarkadas, V., Dyks, J., Dyrda, M., Ebr, J., Edy, E., Egberts, K., Eger, P., Einecke, S., Eleftheriadis, C., Elles, S., Emmanoulopoulos, D., Engelhaupt, D., Enomoto, R., Ernenwein, J. -P., Errando, M., Etchegoyen, A., Evans, P. A., Falcone, A., Faltenbacher, A., Fantinel, D., Farakos, K., Farnier, C., Farrell, E., Fasola, G., Favill, B. W., Fede, E., Federici, S., Fegan, S., Feinstein, F., Ferenc, D., Ferrando, P., Fesquet, M., Fetfatzis, P., Fiasson, A., Fillin-Martino, E., Fink, D., Finley, C., Finley, J. P., Fiorini, M., Curcoll, R. Firpo, Flandrini, E., Fleischhack, H., Flores, H., Florin, D., Focke, W., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fornasa, M., Förster, A., Fortson, L., Fouque, N., Franckowiak, A., Franco, F. J., Frankowski, A., Fransson, C., Fraser, G. W., Frei, R., Fresnillo, L., Fruck, C., Fugazza, D., Fujita, Y., Fukazawa, Y., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gabriele, R., Gadola, A., Galante, N., Gall, D., Gallant, Y., Gámez-García, J., Garczarczyk, M., García, B., López, R. Garcia, Gardiol, D., Gargano, F., Garrido, D., Garrido, L., Gascon, D., Gaug, M., Gaweda, J., Gebremedhin, L., Geffroy, N., Gerard, L., Ghedina, A., Ghigo, M., Ghislain, P., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Giglietto, N., Gika, V., Giomi, M., Giommi, P., Giordano, F., Girard, N., Giro, E., Giuliani, A., Glanzman, T., Glicenstein, J. -F., Godinovic, N., Golev, V., Berisso, M. Gomez, Gómez-Ortega, J., Gonzalez, M. M., González, A., González, F., Muñoz, A. González, Gothe, K. S., Grabarczyk, T., Gougerot, M., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A., Greenshaw, T., Grégoire, T., Grillo, A., Grimm, O., Grondin, M. -H., Grube, J., Grudzinska, M., Gruev, V., Grünewald, S., Grygorczuk, J., Guarino, V., Gunji, S., Gyuk, G., Hadasch, D., Hagedorn, A., Hagiwara, R., Hahn, J., Hakansson, N., Hallgren, A., Heras, N. Hamer, Hara, S., Hardcastle, M. J., Harezlak, D., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Herrero, A., Hervet, O., Hidaka, N., Hinton, J. A., Hirotani, K., Hoffmann, D., Hofmann, W., Hofverberg, P., Holder, J., Hörandel, J. R., Horns, D., Horville, D., Houles, J., Hrabovsky, M., Hrupec, D., Huan, H., Huber, B., Huet, J. -M., Hughes, G., Humensky, T. B., Huovelin, J., Huppert, J. -F., Ibarra, A., Ikawa, D., Illa, J. M., Impiombato, D., Incorvaia, S., Inoue, S., Inoue, Y., Iocco, F., Ioka, K., Israel, G. L., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janiak, M., Jean, P., Jeanney, C., Jimenez, J. J., Jogler, T., Johnson, C., Johnson, T., Journet, L., Juffroy, C., Jung, I., Kaaret, P., Kabuki, S., Kagaya, M., Kakuwa, J., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Kasperek, J., Kastana, D., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kazanas, D., Kelley-Hoskins, N., Kellner-Leidel, B., Kelly, H., Kendziorra, E., Khélifi, B., Kieda, D. B., Kifune, T., Kihm, T., Kishimoto, T., Kitamoto, K., Kluźniak, W., Knapic, C., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodani, K., Köhne, J. -H., Kohri, K., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Köppel, H., Korohoda, P., Kosack, K., Koss, G., Kossakowski, R., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Krähenbühl, T., Krause, J., Krawzcynski, H., Krennrich, F., Krepps, A., Kretzschmann, A., Krobot, R., Krueger, P., Kubo, H., Kudryavtsev, V. A., Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lacombe, K., Lamanna, G., Lande, J., Languignon, D., Lapington, J. S., Laporte, P., Laurent, B., Lavalley, C., Flour, T. Le, Padellec, A. Le, Lee, S. -H., Lee, W. H., Lefèvre, J. -P., Leich, H., de Oliveira, M. A. Leigui, Lelas, D., Lenain, J. -P., Leoni, R., Leopold, D. J., Lerch, T., Lessio, L., Leto, G., Lieunard, B., Lieunard, S., Lindemann, R., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Lombardi, S., Longo, F., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Lorca, A., Lorenz, E., Louis, F., Lubinski, P., Lucarelli, F., Lüdecke, H., Ludwin, J., Luque-Escamilla, P. L., Lustermann, W., Luz, O., Lyard, E., Maccarone, M. C., Maccarone, T. J., Madejski, G. M., Madhavan, A., Mahabir, M., Maier, G., Majumdar, P., Malaguti, G., Malaspina, G., Maltezos, S., Manalaysay, A., Mancilla, A., Mandat, D., Maneva, G., Mangano, A., Manigot, P., Mannheim, K., Manthos, I., Maragos, N., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J. -M., Martin, P., Martínez, G., Martínez, F., Martínez, M., Massaro, F., Masserot, A., Mastichiadis, A., Mathieu, A., Matsumoto, H., Mattana, F., Mattiazzo, S., Maurer, A., Maurin, G., Maxfield, S., Maya, J., Mazin, D., Comb, L. Mc, McCann, A., McCubbin, N., McHardy, I., McKay, R., Meagher, K., Medina, C., Melioli, C., Melkumyan, D., Melo, D., Mereghetti, S., Mertsch, P., Meucci, M., Meyer, M., Michałowski, J., Micolon, P., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mistò, A., Mizuno, T., Moal, B., Moderski, R., Mognet, I., Molinari, E., Molinaro, M., Montaruli, T., Monte, C., Monteiro, I., Moore, P., Olaizola, A. Moralejo, Mordalska, M., Morello, C., Mori, K., Morlino, G., Morselli, A., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mukherjee, R., Munar-Adrover, P., Muraishi, H., Murase, K., Murphy, A. StJ., Nagataki, S., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, C., Naumann, D., Naumann-Godo, M., Nayman, P., Nedbal, D., Neise, D., Nellen, L., Neronov, A., Neustroev, V., Neyroud, N., Nicastro, L., Nicolau-Kukliński, J., Niedźwiecki, A., Niemiec, J., Nieto, D., Nikolaidis, A., Nishijima, K., Nishikawa, K. -I., Noda, K., Nolan, S., Northrop, R., Nosek, D., Nowak, N., Nozato, A., Oakes, L., O'Brien, P. T., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okuda, T., Okumura, A., Olive, J. -F., Ong, R. A., Orito, R., Orr, M., Osborne, J. P., Ostrowski, M., Otero, L. A., Otte, N., Ovcharov, E., Oya, I., Ozieblo, A., Padilla, L., Pagano, I., Paiano, S., Paillot, D., Paizis, A., Palanque, S., Palatka, M., Pallota, J., Palatiello, M., Panagiotidis, K., Panazol, J. -L., Paneque, D., Panter, M., Panzera, M. R., Paoletti, R., Papayannis, A., Papyan, G., Paredes, J. M., Pareschi, G., Parraud, J. -M., Parsons, D., Pauletta, G., Arribas, M. Paz, Pech, M., Pedaletti, G., Pelassa, V., Pelat, D., Perez, M. d. C., Persic, M., Petrucci, P. -O., Peyaud, B., Pichel, A., Pieloth, D., Pierre, E., Pita, S., Pivato, G., Pizzolato, F., Platino, M., Platos, Ł., Platzer, R., Podkladkin, S., Pogosyan, L., Pohl, M., Pojmanski, G., Ponz, J. D., Potter, W., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokoph, H., Prouza, M., Proyetti, M., Puerto-Giménez, I., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Quel, E. J., Quesada, J., Quinn, J., Quirrenbach, A., Racero, E., Rainò, S., Rajda, P. J., Rameez, M., Ramon, P., Rando, R., Rannot, R. C., Rataj, M., Raue, M., Ravignani, D., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reville, B., Rhode, W., Ribó, M., Ribordy, M., Richards, G., Richer, M. G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ripken, J., Ristori, P. R., Rivière, A., Rivoire, S., Rob, L., Rodeghiero, G., Roeser, U., Rohlfs, R., Rojas, G., Romano, P., Romaszkan, W., Romero, G. E., Rosen, S. R., Lees, S. Rosier, Ross, D., Rouaix, G., Rousselle, J., Rousselle, S., Rovero, A. C., Roy, F., Royer, S., Rudak, B., Rulten, C., Rupiński, M., Russo, F., Ryde, F., Saavedra, O., Sacco, B., Saemann, E. O., Saggion, A., Sahakian, V., Saito, K., Saito, T., Saito, Y., Sakaki, N., Sakonaka, R., Salini, A., Sanchez, F., Sanchez-Conde, M., Sandoval, A., Sandaker, H., Sant'Ambrogio, E., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Sartore, N., Sasaki, H., Satalecka, K., Sawada, M., Scalzotto, V., Scapin, V., Scarcioffolo, M., Schafer, J., Schanz, T., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schovanek, P., Schroedter, M., Schubert, A., Schultz, C., Schultze, J., Schulz, A., Schure, K., Schussler, F., Schwab, T., Schwanke, U., Schwarz, J., Schwarzburg, S., Schweizer, T., Schwemmer, S., Schwendicke, U., Schwerdt, C., Segreto, A., Seiradakis, J. -H., Sembroski, G. H., Servillat, M., Seweryn, K., Sharma, M., Shayduk, M., Shellard, R. C., Shi, J., Shibata, T., Shibuya, A., Shore, S., Shum, E., Sideras-Haddad, E., Sidoli, L., Sidz, M., Sieiro, J., Sikora, M., Silk, J., Sillanpää, A., Singh, B. B., Sironi, G., Sitarek, J., Skole, C., Smareglia, R., Smith, A., Smith, D., Smith, J., Smith, N., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spiga, D., Spyrou, S., Stamatescu, V., Stamerra, A., Starling, R. L. C., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steiner, S., Stella, C., Stergioulas, N., Sternberger, R., Sterzel, M., Stinzing, F., Stodulski, M., Stolarczyk, Th., Straumann, U., Strazzeri, E., Stringhetti, L., Suarez, A., Suchenek, M., Sugawara, R., Sulanke, K. -H., Sun, S., Supanitsky, A. D., Suric, T., Sutcliffe, P., Sykes, J. M., Szanecki, M., Szepieniec, T., Szostek, A., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tasan, J., Tavani, M., Tavernet, J. -P., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Teshima, M., Testa, V., Tezier, D., Thayer, J., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Timpanaro, M. C., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tonachini, A., Torii, K., Tornikoski, M., Torres, D. F., Torres, M., Toscano, S., Toso, G., Tosti, G., Totani, T., Toussenel, F., Tovmassian, G., Travnicek, P., Treves, A., Trifoglio, M., Troyano, I., Tsinganos, K., Ueno, H., Umana, G., Umehara, K., Upadhya, S. S., Usher, T., Uslenghi, M., Vagnetti, F., Valdes-Galicia, J. F., Vallania, P., Vallejo, G., van Driel, W., van Eldik, C., Vandenbrouke, J., Vanderwalt, J., Vankov, H., Vasileiadis, G., Vassiliev, V., Veberic, D., Vegas, I., Vercellone, S., Vergani, S., Verzi, V., Vettolani, G. P., Veyssière, C., Vialle, J. P., Viana, A., Videla, M., Vigorito, C., Vincent, P., Vincent, S., Vink, J., Vlahakis, N., Vlahos, L., Vogler, P., Voisin, V., Vollhardt, A., von Gunten, H. -P., Vorobiov, S., Vuerli, C., Waegebaert, V., Wagner, R., Wagner, R. G., Wagner, S., Wakely, S. P., Walter, R., Walther, T., Warda, K., Warwick, R. S., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Welsing, R., Werner, M., Wetteskind, H., White, R. J., Wierzcholska, A., Wiesand, S., Wilhelm, A., Wilkinson, M. I., Williams, D. A., Willingale, R., Winde, M., Winiarski, K., Wischnewski, R., Wiśniewski, Ł., Wojcik, P., Wood, M., Wörnlein, A., Xiong, Q., Yadav, K. K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yebras, J. M., Yelos, D., Yoshida, A., Yoshida, T., Yoshikoshi, T., Yu, P., Zabalza, V., Zacharias, M., Zajczyk, A., Zampieri, L., Zanin, R., Zdziarski, A., Zech, A., Zhao, A., Zhou, X., Zietara, K., Ziolkowski, J., Ziółkowski, P., Zitelli, V., Zurbach, C., and Zychowski, P.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: Compilation of CTA contributions to the proceedings of the 33rd International Cosmic Ray Conference (ICRC2013), which took place in 2-9 July, 2013, in Rio de Janeiro, Brazil, Comment: Index of CTA conference proceedings at the ICRC2013, Rio de Janeiro (Brazil). v1: placeholder with no arXiv links yet, to be replaced once individual contributions have been all submitted. v2: final with arXiv links to all CTA contributions and full author list
Published: 2013

22. Climate impact of alcohol consumption in Sweden

Author: Hallström, E., Håkansson, N., Åkesson, A., Wolk, A., and Sonesson, U.
Published: 2018
Full Text: View/download PDF

23. Labour and Landscapes: The Political Economy of Landesque Capital in Nineteenth Century Tanganyika

Author: Håkansson, N. Thomas and Widgren, Mats
Published: 2007

24. The Human Ecology of World Systems in East Africa: The Impact of the Ivory Trade

Author: Håkansson, N. Thomas
Published: 2004

25. Rulers and Rainmakers in Precolonial South Pare, Tanzania: Exchange and Ritual Experts in Political Centralization

Author: Håkansson, N. Thomas
Published: 1998
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26. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies

Author: Genkinger, J.M., Wang, M., Li, R., Albanes, D., Anderson, K.E., Bernstein, L., van den Brandt, P.A., English, D.R., Freudenheim, J.L., Fuchs, C.S., Gapstur, S.M., Giles, G.G., Goldbohm, R.A., Håkansson, N., Horn-Ross, P.L., Koushik, A., Marshall, J.R., McCullough, M.L., Miller, A.B., Robien, K., Rohan, T.E., Schairer, C., Silverman, D.T., Stolzenberg-Solomon, R.Z., Virtamo, J., Willett, W.C., Wolk, A., Ziegler, R.G., and Smith-Warner, S.A.
Published: 2014
Full Text: View/download PDF

27. Introducing the CTA concept

Author: Acharya, B.S., Actis, M., Aghajani, T., Agnetta, G., Aguilar, J., Aharonian, F., Ajello, M., Akhperjanian, A., Alcubierre, M., Aleksić, J., Alfaro, R., Aliu, E., Allafort, A.J., Allan, D., Allekotte, I., Amato, E., Anderson, J., Angüner, E.O., Antonelli, L.A., Antoranz, P., Aravantinos, A., Arlen, T., Armstrong, T., Arnaldi, H., Arrabito, L., Asano, K., Ashton, T., Asorey, H.G., Awane, Y., Baba, H., Babic, A., Baby, N., Bähr, J., Bais, A., Baixeras, C., Bajtlik, S., Balbo, M., Balis, D., Balkowski, C., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barceló, M., Barnacka, A., Barnstedt, J., Barres de Almeida, U., Barrio, J.A., Basili, A., Basso, S., Bastieri, D., Bauer, C., Baushev, A., Becerra, J., Becherini, Y., Bechtol, K.C., Becker Tjus, J., Beckmann, V., Bednarek, W., Behera, B., Belluso, M., Benbow, W., Berdugo, J., Berger, K., Bernard, F., Bernardino, T., Bernlöhr, K., Bhat, N., Bhattacharyya, S., Bigongiari, C., Biland, A., Billotta, S., Bird, T., Birsin, E., Bissaldi, E., Biteau, J., Bitossi, M., Blake, S., Blanch Bigas, O., Blasi, P., Bobkov, A., Boccone, V., Boettcher, M., Bogacz, L., Bogart, J., Bogdan, M., Boisson, C., Boix Gargallo, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonev, T., Bonifacio, P., Bonnoli, G., Bordas, P., Borgland, A., Borkowski, J., Bose, R., Botner, O., Bottani, A., Bouchet, L., Bourgeat, M., Boutonnet, C., Bouvier, A., Brau-Nogué, S., Braun, I., Bretz, T., Briggs, M., Bringmann, T., Brook, P., Brun, P., Brunetti, L., Buanes, T., Buckley, J., Buehler, R., Bugaev, V., Bulgarelli, A., Bulik, T., Busetto, G., Buson, S., Byrum, K., Cailles, M., Cameron, R., Camprecios, J., Canestrari, R., Cantu, S., Capalbi, M., Caraveo, P., Carmona, E., Carosi, A., Carr, J., Carton, P.-H., Casanova, S., Casiraghi, M., Catalano, O., Cavazzani, S., Cazaux, S., Cerruti, M., Chabanne, E., Chadwick, P., Champion, C., Chen, A., Chiang, J., Chiappetti, L., Chikawa, M., Chitnis, V.R., Chollet, F., Chudoba, J., Cieślar, M., Cillis, A., Cohen-Tanugi, J., Colafrancesco, S., Colin, P., Colome, J., Colonges, S., Compin, M., Conconi, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J.L., Coppi, P., Corona, P., Corti, D., Cortina, J., Cossio, L., Costantini, H., Cotter, G., Courty, B., Couturier, S., Covino, S., Crimi, G., Criswell, S.J., Croston, J., Cusumano, G., Dafonseca, M., Dale, O., Daniel, M., Darling, J., Davids, I., Dazzi, F., De Angelis, A., De Caprio, V., De Frondat, F., de Gouveia Dal Pino, E.M., de la Calle, I., De La Vega, G.A., de los Reyes Lopez, R., De Lotto, B., De Luca, A., de Mello Neto, J.R.T., de Naurois, M., de Oliveira, Y., de Oña Wilhelmi, E., de Souza, V., Decerprit, G., Decock, G., Deil, C., Delagnes, E., Deleglise, G., Delgado, C., Della Volpe, D., Demange, P., Depaola, G., Dettlaff, A., Di Paola, A., Di Pierro, F., Díaz, C., Dick, J., Dickherber, R., Dickinson, H., Diez-Blanco, V., Digel, S., Dimitrov, D., Disset, G., Djannati-Ataï, A., Doert, M., Dohmke, M., Domainko, W., Dominis Prester, D., Donat, A., Dorner, D., Doro, M., Dournaux, J.-L., Drake, G., Dravins, D., Drury, L., Dubois, F., Dubois, R., Dubus, G., Dufour, C., Dumas, D., Dumm, J., Durand, D., Dyks, J., Dyrda, M., Ebr, J., Edy, E., Egberts, K., Eger, P., Einecke, S., Eleftheriadis, C., Elles, S., Emmanoulopoulos, D., Engelhaupt, D., Enomoto, R., Ernenwein, J.-P., Errando, M., Etchegoyen, A., Evans, P., Falcone, A., Fantinel, D., Farakos, K., Farnier, C., Fasola, G., Favill, B., Fede, E., Federici, S., Fegan, S., Feinstein, F., Ferenc, D., Ferrando, P., Fesquet, M., Fiasson, A., Fillin-Martino, E., Fink, D., Finley, C., Finley, J.P., Fiorini, M., Firpo Curcoll, R., Flores, H., Florin, D., Focke, W., Föhr, C., Fokitis, E., Font, L., Fontaine, G., Fornasa, M., Förster, A., Fortson, L., Fouque, N., Franckowiak, A., Fransson, C., Fraser, G., Frei, R., Albuquerque, I.F.M., Fresnillo, L., Fruck, C., Fujita, Y., Fukazawa, Y., Fukui, Y., Funk, S., Gäbele, W., Gabici, S., Gabriele, R., Gadola, A., Galante, N., Gall, D., Gallant, Y., Gámez-García, J., García, B., Garcia López, R., Gardiol, D., Garrido, D., Garrido, L., Gascon, D., Gaug, M., Gaweda, J., Gebremedhin, L., Geffroy, N., Gerard, L., Ghedina, A., Ghigo, M., Giannakaki, E., Gianotti, F., Giarrusso, S., Giavitto, G., Giebels, B., Gika, V., Giommi, P., Girard, N., Giro, E., Giuliani, A., Glanzman, T., Glicenstein, J.-F., Godinovic, N., Golev, V., Gomez Berisso, M., Gómez-Ortega, J., Gonzalez, M.M., González, A., González, F., González Muñoz, A., Gothe, K.S., Gougerot, M., Graciani, R., Grandi, P., Grañena, F., Granot, J., Grasseau, G., Gredig, R., Green, A., Greenshaw, T., Grégoire, T., Grimm, O., Grube, J., Grudzinska, M., Gruev, V., Grünewald, S., Grygorczuk, J., Guarino, V., Gunji, S., Gyuk, G., Hadasch, D., Hagiwara, R., Hahn, J., Hakansson, N., Hallgren, A., Hamer Heras, N., Hara, S., Hardcastle, M.J., Harris, J., Hassan, T., Hatanaka, K., Haubold, T., Haupt, A., Hayakawa, T., Hayashida, M., Heller, R., Henault, F., Henri, G., Hermann, G., Hermel, R., Herrero, A., Hidaka, N., Hinton, J., Hoffmann, D., Hofmann, W., Hofverberg, P., Holder, J., Horns, D., Horville, D., Houles, J., Hrabovsky, M., Hrupec, D., Huan, H., Huber, B., Huet, J.-M., Hughes, G., Humensky, T.B., Huovelin, J., Ibarra, A., Illa, J.M., Impiombato, D., Incorvaia, S., Inoue, S., Inoue, Y., Ioka, K., Ismailova, E., Jablonski, C., Jacholkowska, A., Jamrozy, M., Janiak, M., Jean, P., Jeanney, C., Jimenez, J.J., Jogler, T., Johnson, T., Journet, L., Juffroy, C., Jung, I., Kaaret, P., Kabuki, S., Kagaya, M., Kakuwa, J., Kalkuhl, C., Kankanyan, R., Karastergiou, A., Kärcher, K., Karczewski, M., Karkar, S., Kasperek, J., Kastana, D., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kellner-Leidel, B., Kelly, H., Kendziorra, E., Khélifi, B., Kieda, D.B., Kifune, T., Kihm, T., Kishimoto, T., Kitamoto, K., Kluźniak, W., Knapic, C., Knapp, J., Knödlseder, J., Köck, F., Kocot, J., Kodani, K., Köhne, J.-H., Kohri, K., Kokkotas, K., Kolitzus, D., Komin, N., Kominis, I., Konno, Y., Köppel, H., Korohoda, P., Kosack, K., Koss, G., Kossakowski, R., Kostka, P., Koul, R., Kowal, G., Koyama, S., Kozioł, J., Krähenbühl, T., Krause, J., Krawzcynski, H., Krennrich, F., Krepps, A., Kretzschmann, A., Krobot, R., Krueger, P., Kubo, H., Kudryavtsev, V.A., Kushida, J., Kuznetsov, A., La Barbera, A., La Palombara, N., La Parola, V., La Rosa, G., Lacombe, K., Lamanna, G., Lande, J., Languignon, D., Lapington, J., Laporte, P., Lavalley, C., Le Flour, T., Le Padellec, A., Lee, S.-H., Lee, W.H., Leigui de Oliveira, M.A., Lelas, D., Lenain, J.-P., Leopold, D.J., Lerch, T., Lessio, L., Lieunard, B., Lindfors, E., Liolios, A., Lipniacka, A., Lockart, H., Lohse, T., Lombardi, S., Lopatin, A., Lopez, M., López-Coto, R., López-Oramas, A., Lorca, A., Lorenz, E., Lubinski, P., Lucarelli, F., Lüdecke, H., Ludwin, J., Luque-Escamilla, P.L., Lustermann, W., Luz, O., Lyard, E., Maccarone, M.C., Maccarone, T.J., Madejski, G.M., Madhavan, A., Mahabir, M., Maier, G., Majumdar, P., Malaguti, G., Maltezos, S., Manalaysay, A., Mancilla, A., Mandat, D., Maneva, G., Mangano, A., Manigot, P., Mannheim, K., Manthos, I., Maragos, N., Marcowith, A., Mariotti, M., Marisaldi, M., Markoff, S., Marszałek, A., Martens, C., Martí, J., Martin, J.-M., Martin, P., Martínez, G., Martínez, F., Martínez, M., Masserot, A., Mastichiadis, A., Mathieu, A., Matsumoto, H., Mattana, F., Mattiazzo, S., Maurin, G., Maxfield, S., Maya, J., Mazin, D., Mc Comb, L., McCubbin, N., McHardy, I., McKay, R., Medina, C., Melioli, C., Melkumyan, D., Mereghetti, S., Mertsch, P., Meucci, M., Michałowski, J., Micolon, P., Mihailidis, A., Mineo, T., Minuti, M., Mirabal, N., Mirabel, F., Miranda, J.M., Mirzoyan, R., Mizuno, T., Moal, B., Moderski, R., Mognet, I., Molinari, E., Molinaro, M., Montaruli, T., Monteiro, I., Moore, P., Moralejo Olaizola, A., Mordalska, M., Morello, C., Mori, K., Mottez, F., Moudden, Y., Moulin, E., Mrusek, I., Mukherjee, R., Munar-Adrover, P., Muraishi, H., Murase, K., Murphy, A., Nagataki, S., Naito, T., Nakajima, D., Nakamori, T., Nakayama, K., Naumann, C., Naumann, D., Naumann-Godo, M., Nayman, P., Nedbal, D., Neise, D., Nellen, L., Neustroev, V., Neyroud, N., Nicastro, L., Nicolau-Kukliński, J., Niedźwiecki, A., Niemiec, J., Nieto, D., Nikolaidis, A., Nishijima, K., Nolan, S., Northrop, R., Nosek, D., Nowak, N., Nozato, A., O’Brien, P., Ohira, Y., Ohishi, M., Ohm, S., Ohoka, H., Okuda, T., Okumura, A., Olive, J.-F., Ong, R.A., Orito, R., Orr, M., Osborne, J., Ostrowski, M., Otero, L.A., Otte, N., Ovcharov, E., Oya, I., Ozieblo, A., Padilla, L., Paiano, S., Paillot, D., Paizis, A., Palanque, S., Palatka, M., Pallota, J., Panagiotidis, K., Panazol, J.-L., Paneque, D., Panter, M., Paoletti, R., Papayannis, A., Papyan, G., Paredes, J.M., Pareschi, G., Parks, G., Parraud, J.-M., Parsons, D., Paz Arribas, M., Pech, M., Pedaletti, G., Pelassa, V., Pelat, D., Perez, M.d.C., Persic, M., Petrucci, P.-O., Peyaud, B., Pichel, A., Pita, S., Pizzolato, F., Platos, Ł., Platzer, R., Pogosyan, L., Pohl, M., Pojmanski, G., Ponz, J.D., Potter, W., Poutanen, J., Prandini, E., Prast, J., Preece, R., Profeti, F., Prokoph, H., Prouza, M., Proyetti, M., Puerto-Gimenez, I., Pühlhofer, G., Puljak, I., Punch, M., Pyzioł, R., Quel, E.J., Quinn, J., Quirrenbach, A., Racero, E., Rajda, P.J., Ramon, P., Rando, R., Rannot, R.C., Rataj, M., Raue, M., Reardon, P., Reimann, O., Reimer, A., Reimer, O., Reitberger, K., Renaud, M., Renner, S., Reville, B., Rhode, W., Ribó, M., Ribordy, M., Richer, M.G., Rico, J., Ridky, J., Rieger, F., Ringegni, P., Ripken, J., Ristori, P.R., Riviére, A., Rivoire, S., Rob, L., Roeser, U., Rohlfs, R., Rojas, G., Romano, P., Romaszkan, W., Romero, G.E., Rosen, S., Rosier Lees, S., Ross, D., Rouaix, G., Rousselle, J., Rousselle, S., Rovero, A.C., Roy, F., Royer, S., Rudak, B., Rulten, C., Rupiński, M., Russo, F., Ryde, F., Sacco, B., Saemann, E.O., Saggion, A., Sahakian, V., Saito, K., Saito, T., Saito, Y., Sakaki, N., Sakonaka, R., Salini, A., Sanchez, F., Sanchez-Conde, M., Sandoval, A., Sandaker, H., Sant’Ambrogio, E., Santangelo, A., Santos, E.M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Sartore, N., Sasaki, H., Satalecka, K., Sawada, M., Scalzotto, V., Scapin, V., Scarcioffolo, M., Schafer, J., Schanz, T., Schlenstedt, S., Schlickeiser, R., Schmidt, T., Schmoll, J., Schovanek, P., Schroedter, M., Schultz, C., Schultze, J., Schulz, A., Schure, K., Schwab, T., Schwanke, U., Schwarz, J., Schwarzburg, S., Schweizer, T., Schwemmer, S., Segreto, A., Seiradakis, J.-H., Sembroski, G.H., Seweryn, K., Sharma, M., Shayduk, M., Shellard, R.C., Shi, J., Shibata, T., Shibuya, A., Shum, E., Sidoli, L., Sidz, M., Sieiro, J., Sikora, M., Silk, J., Sillanpää, A., Singh, B.B., Sitarek, J., Skole, C., Smareglia, R., Smith, A., Smith, D., Smith, J., Smith, N., Sobczyńska, D., Sol, H., Sottile, G., Sowiński, M., Spanier, F., Spiga, D., Spyrou, S., Stamatescu, V., Stamerra, A., Starling, R., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steiner, S., Stergioulas, N., Sternberger, R., Sterzel, M., Stinzing, F., Stodulski, M., Straumann, U., Strazzeri, E., Stringhetti, L., Suarez, A., Suchenek, M., Sugawara, R., Sulanke, K.-H., Sun, S., Supanitsky, A.D., Suric, T., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Szostek, A., Tagliaferri, G., Tajima, H., Takahashi, H., Takahashi, K., Takalo, L., Takami, H., Talbot, G., Tammi, J., Tanaka, M., Tanaka, S., Tasan, J., Tavani, M., Tavernet, J.-P., Tejedor, L.A., Telezhinsky, I., Temnikov, P., Tenzer, C., Terada, Y., Terrier, R., Teshima, M., Testa, V., Tezier, D., Thuermann, D., Tibaldo, L., Tibolla, O., Tiengo, A., Tluczykont, M., Todero Peixoto, C.J., Tokanai, F., Tokarz, M., Toma, K., Torii, K., Tornikoski, M., Torres, D.F., Torres, M., Tosti, G., Totani, T., Toussenel, F., Tovmassian, G., Travnicek, P., Trifoglio, M., Troyano, I., Tsinganos, K., Ueno, H., Umehara, K., Upadhya, S.S., Usher, T., Uslenghi, M., Valdes-Galicia, J.F., Vallania, P., Vallejo, G., van Driel, W., van Eldik, C., Vandenbrouke, J., Vanderwalt, J., Vankov, H., Vasileiadis, G., Vassiliev, V., Veberic, D., Vegas, I., Vercellone, S., Vergani, S., Veyssiére, C., Vialle, J.P., Viana, A., Videla, M., Vincent, P., Vincent, S., Vink, J., Vlahakis, N., Vlahos, L., Vogler, P., Vollhardt, A., von Gunten, H.-P., Vorobiov, S., Vuerli, C., Waegebaert, V., Wagner, R., Wagner, R.G., Wagner, S., Wakely, S.P., Walter, R., Walther, T., Warda, K., Warwick, R., Wawer, P., Wawrzaszek, R., Webb, N., Wegner, P., Weinstein, A., Weitzel, Q., Welsing, R., Werner, M., Wetteskind, H., White, R., Wierzcholska, A., Wiesand, S., Wilkinson, M., Williams, D.A., Willingale, R., Winiarski, K., Wischnewski, R., Wiśniewski, Ł., Wood, M., Wörnlein, A., Xiong, Q., Yadav, K.K., Yamamoto, H., Yamamoto, T., Yamazaki, R., Yanagita, S., Yebras, J.M., Yelos, D., Yoshida, A., Yoshida, T., Yoshikoshi, T., Zabalza, V., Zacharias, M., Zajczyk, A., Zanin, R., Zdziarski, A., Zech, A., Zhao, A., Zhou, X., Ziętara, K., Ziolkowski, J., Ziółkowski, P., Zitelli, V., Zurbach, C., and Żychowski, P.
Published: 2013
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28. Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Author: Dareng, EO, Tyrer, JP, Barnes, DR, Jones, MR, Yang, X, Aben, KKH, Adank, MA, Agata, S, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Arun, BK, Augustinsson, A, Balmana, J, Bandera, E, Barkardottir, RB, Barrowdale, D, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bermisheva, M, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, N, Bonanni, B, Borg, A, Brenton, JD, Budzilowska, A, Butzow, R, Buys, SS, Cai, H, Caligo, MA, Campbell, I, Cannioto, R, Cassingham, H, Chang-Claude, J, Chanock, SJ, Chen, K, Chiew, Y-E, Chung, WK, Claes, KBM, Colonna, S, Cook, LS, Couch, FJ, Daly, MB, Dao, F, Davies, E, de la Hoya, M, de Putter, R, Dennis, J, DePersia, A, Devilee, P, Diez, O, Ding, YC, Doherty, JA, Domchek, SM, Dork, T, du Bois, A, Durst, M, Eccles, DM, Eliassen, HA, Engel, C, Evans, GD, Fasching, PA, Flanagan, JM, Fortner, R, Machackova, E, Friedman, E, Ganz, PA, Garber, J, Gensini, F, Giles, GG, Glendon, G, Godwin, AK, Goodman, MT, Greene, MH, Gronwald, J, Group, OS, AOCSGroup, Hahnen, E, Haiman, CA, Hakansson, N, Hamann, U, Hansen, TVO, Harris, HR, Hartman, M, Heitz, F, Hildebrandt, MAT, Hogdall, E, Hogdall, CK, Hopper, JL, Huang, R-Y, Huff, C, Hulick, PJ, Huntsman, DG, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, PA, Janavicius, R, Jensen, A, Johannsson, OT, John, EM, Jones, ME, Kang, D, Karlan, BY, Karnezis, A, Kelemen, LE, Khusnutdinova, E, Kiemeney, LA, Kim, B-G, Kjaer, SK, Komenaka, I, Kupryjanczyk, J, Kurian, AW, Kwong, A, Lambrechts, D, Larson, MC, Lazaro, C, Le, ND, Leslie, G, Lester, J, Lesueur, F, Levine, DA, Li, L, Li, J, Loud, JT, Lu, KH, Mai, PL, Manoukian, S, Marks, JR, KimMatsuno, R, Matsuo, K, May, T, McGuffog, L, McLaughlin, JR, McNeish, IA, Mebirouk, N, Menon, U, Miller, A, Milne, RL, Minlikeeva, A, Modugno, F, Montagna, M, Moysich, KB, Munro, E, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Yie, JNY, Nielsen, HR, Nielsen, FC, Nikitina-Zake, L, Odunsi, K, Offit, K, Olah, E, Olbrecht, S, Olopade, O, Olson, SH, Olsson, H, Osorio, A, Papi, L, Park, SK, Parsons, MT, Pathak, H, Pedersen, IS, Peixoto, A, Pejovic, T, Perez-Segura, P, Permuth, JB, Peshkin, B, Peterlongo, P, Piskorz, A, Prokofyeva, D, Radice, P, Rantala, J, Riggan, MJ, Risch, HA, Rodriguez-Antona, C, Ross, E, Rossing, MA, Runnebaum, I, Sandler, DP, Santamarina, M, Soucy, P, Schmutzler, RK, Setiawan, VW, Shan, K, Sieh, W, Simard, J, Singer, CF, Sokolenko, AP, Song, H, Southey, MC, Steed, H, Stoppa-Lyonnet, D, Sutphen, R, Swerdlow, AJ, Tan, YY, Teixeira, MR, Teo, SH, Terry, KL, BethTerry, M, Thomassen, M, Thompson, PJ, Thomsen, LCV, Thull, DL, Tischkowitz, M, Titus, L, Toland, AE, Torres, D, Trabert, B, Travis, R, Tung, N, Tworoger, SS, Valen, E, van Altena, AM, van der Hout, AH, Nieuwenhuysen, E, van Rensburg, EJ, Vega, A, Edwards, DV, Vierkant, RA, Wang, F, Wappenschmidt, B, Webb, PM, Weinberg, CR, Weitzel, JN, Wentzensen, N, White, E, Whittemore, AS, Winham, SJ, Wolk, A, Woo, Y-L, Wu, AH, Yan, L, Yannoukakos, D, Zavaglia, KM, Zheng, W, Ziogas, A, Zorn, KK, Kleibl, Z, Easton, D, Lawrenson, K, DeFazio, A, Sellers, TA, Ramus, SJ, Pearce, CL, Monteiro, AN, Cunningham, J, Goode, EL, Schildkraut, JM, Berchuck, A, Chenevix-Trench, G, Gayther, SA, Antoniou, AC, Pharoah, PDP, Dareng, EO, Tyrer, JP, Barnes, DR, Jones, MR, Yang, X, Aben, KKH, Adank, MA, Agata, S, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Arun, BK, Augustinsson, A, Balmana, J, Bandera, E, Barkardottir, RB, Barrowdale, D, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bermisheva, M, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, N, Bonanni, B, Borg, A, Brenton, JD, Budzilowska, A, Butzow, R, Buys, SS, Cai, H, Caligo, MA, Campbell, I, Cannioto, R, Cassingham, H, Chang-Claude, J, Chanock, SJ, Chen, K, Chiew, Y-E, Chung, WK, Claes, KBM, Colonna, S, Cook, LS, Couch, FJ, Daly, MB, Dao, F, Davies, E, de la Hoya, M, de Putter, R, Dennis, J, DePersia, A, Devilee, P, Diez, O, Ding, YC, Doherty, JA, Domchek, SM, Dork, T, du Bois, A, Durst, M, Eccles, DM, Eliassen, HA, Engel, C, Evans, GD, Fasching, PA, Flanagan, JM, Fortner, R, Machackova, E, Friedman, E, Ganz, PA, Garber, J, Gensini, F, Giles, GG, Glendon, G, Godwin, AK, Goodman, MT, Greene, MH, Gronwald, J, Group, OS, AOCSGroup, Hahnen, E, Haiman, CA, Hakansson, N, Hamann, U, Hansen, TVO, Harris, HR, Hartman, M, Heitz, F, Hildebrandt, MAT, Hogdall, E, Hogdall, CK, Hopper, JL, Huang, R-Y, Huff, C, Hulick, PJ, Huntsman, DG, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, PA, Janavicius, R, Jensen, A, Johannsson, OT, John, EM, Jones, ME, Kang, D, Karlan, BY, Karnezis, A, Kelemen, LE, Khusnutdinova, E, Kiemeney, LA, Kim, B-G, Kjaer, SK, Komenaka, I, Kupryjanczyk, J, Kurian, AW, Kwong, A, Lambrechts, D, Larson, MC, Lazaro, C, Le, ND, Leslie, G, Lester, J, Lesueur, F, Levine, DA, Li, L, Li, J, Loud, JT, Lu, KH, Mai, PL, Manoukian, S, Marks, JR, KimMatsuno, R, Matsuo, K, May, T, McGuffog, L, McLaughlin, JR, McNeish, IA, Mebirouk, N, Menon, U, Miller, A, Milne, RL, Minlikeeva, A, Modugno, F, Montagna, M, Moysich, KB, Munro, E, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Yie, JNY, Nielsen, HR, Nielsen, FC, Nikitina-Zake, L, Odunsi, K, Offit, K, Olah, E, Olbrecht, S, Olopade, O, Olson, SH, Olsson, H, Osorio, A, Papi, L, Park, SK, Parsons, MT, Pathak, H, Pedersen, IS, Peixoto, A, Pejovic, T, Perez-Segura, P, Permuth, JB, Peshkin, B, Peterlongo, P, Piskorz, A, Prokofyeva, D, Radice, P, Rantala, J, Riggan, MJ, Risch, HA, Rodriguez-Antona, C, Ross, E, Rossing, MA, Runnebaum, I, Sandler, DP, Santamarina, M, Soucy, P, Schmutzler, RK, Setiawan, VW, Shan, K, Sieh, W, Simard, J, Singer, CF, Sokolenko, AP, Song, H, Southey, MC, Steed, H, Stoppa-Lyonnet, D, Sutphen, R, Swerdlow, AJ, Tan, YY, Teixeira, MR, Teo, SH, Terry, KL, BethTerry, M, Thomassen, M, Thompson, PJ, Thomsen, LCV, Thull, DL, Tischkowitz, M, Titus, L, Toland, AE, Torres, D, Trabert, B, Travis, R, Tung, N, Tworoger, SS, Valen, E, van Altena, AM, van der Hout, AH, Nieuwenhuysen, E, van Rensburg, EJ, Vega, A, Edwards, DV, Vierkant, RA, Wang, F, Wappenschmidt, B, Webb, PM, Weinberg, CR, Weitzel, JN, Wentzensen, N, White, E, Whittemore, AS, Winham, SJ, Wolk, A, Woo, Y-L, Wu, AH, Yan, L, Yannoukakos, D, Zavaglia, KM, Zheng, W, Ziogas, A, Zorn, KK, Kleibl, Z, Easton, D, Lawrenson, K, DeFazio, A, Sellers, TA, Ramus, SJ, Pearce, CL, Monteiro, AN, Cunningham, J, Goode, EL, Schildkraut, JM, Berchuck, A, Chenevix-Trench, G, Gayther, SA, Antoniou, AC, and Pharoah, PDP
Abstract: Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, "select and shrink for summary statistics" (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28-1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08-1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21-1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29-1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35-1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.
Published: 2022

29. Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci

Author: DeVries, AA, Dennis, J, Tyrer, JP, Peng, P-C, Coetzee, SG, Reyes, AL, Plummer, JT, Davis, BD, Chen, SS, Dezem, FS, Aben, KKH, Anton-Culver, H, Antonenkova, NN, Beckmann, MW, Beeghly-Fadiel, A, Berchuck, A, Bogdanova, N, Bogdanova-Markov, N, Brenton, JD, Butzow, R, Campbell, I, Chang-Claude, J, Chenevix-Trench, G, Cook, LS, DeFazio, A, Doherty, JA, Dork, T, Eccles, DM, Eliassen, AH, Fasching, PA, Fortner, RT, Giles, GG, Goode, EL, Goodman, MT, Gronwald, J, Hakansson, N, Hildebrandt, MAT, Huff, C, Huntsman, DG, Jensen, A, Kar, S, Karlan, BY, Khusnutdinova, EK, Kiemeney, LA, Kjaer, SK, Kupryjanczyk, J, Labrie, M, Lambrechts, D, Le, ND, Lubinski, J, May, T, Menon, U, Milne, RL, Modugno, F, Monteiro, AN, Moysich, KB, Odunsi, K, Olsson, H, Pearce, CL, Pejovic, T, Ramus, SJ, Riboli, E, Riggan, MJ, Romieu, I, Sandler, DP, Schildkraut, JM, Setiawan, VW, Sieh, W, Song, H, Sutphen, R, Terry, KL, Thompson, PJ, Titus, L, Tworoger, SS, Van Nieuwenhuysen, E, Edwards, DV, Webb, PM, Wentzensen, N, Whittemore, AS, Wolk, A, Wu, AH, Ziogas, A, Freedman, ML, Lawrenson, K, Pharoah, PDP, Easton, DF, Gayther, SA, Jones, MR, DeVries, AA, Dennis, J, Tyrer, JP, Peng, P-C, Coetzee, SG, Reyes, AL, Plummer, JT, Davis, BD, Chen, SS, Dezem, FS, Aben, KKH, Anton-Culver, H, Antonenkova, NN, Beckmann, MW, Beeghly-Fadiel, A, Berchuck, A, Bogdanova, N, Bogdanova-Markov, N, Brenton, JD, Butzow, R, Campbell, I, Chang-Claude, J, Chenevix-Trench, G, Cook, LS, DeFazio, A, Doherty, JA, Dork, T, Eccles, DM, Eliassen, AH, Fasching, PA, Fortner, RT, Giles, GG, Goode, EL, Goodman, MT, Gronwald, J, Hakansson, N, Hildebrandt, MAT, Huff, C, Huntsman, DG, Jensen, A, Kar, S, Karlan, BY, Khusnutdinova, EK, Kiemeney, LA, Kjaer, SK, Kupryjanczyk, J, Labrie, M, Lambrechts, D, Le, ND, Lubinski, J, May, T, Menon, U, Milne, RL, Modugno, F, Monteiro, AN, Moysich, KB, Odunsi, K, Olsson, H, Pearce, CL, Pejovic, T, Ramus, SJ, Riboli, E, Riggan, MJ, Romieu, I, Sandler, DP, Schildkraut, JM, Setiawan, VW, Sieh, W, Song, H, Sutphen, R, Terry, KL, Thompson, PJ, Titus, L, Tworoger, SS, Van Nieuwenhuysen, E, Edwards, DV, Webb, PM, Wentzensen, N, Whittemore, AS, Wolk, A, Wu, AH, Ziogas, A, Freedman, ML, Lawrenson, K, Pharoah, PDP, Easton, DF, Gayther, SA, and Jones, MR
Abstract: BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotide polymorphism array data from 13 071 EOC cases and 17 306 controls of White European ancestry were used to identify CNVs associated with EOC risk using a rare admixture maximum likelihood test for gene burden and a by-probe ratio test. We performed enrichment analysis of CNVs at known EOC risk loci and functional biofeatures in ovarian cancer-related cell types. RESULTS: We identified statistically significant risk associations with CNVs at known EOC risk genes; BRCA1 (PEOC = 1.60E-21; OREOC = 8.24), RAD51C (Phigh-grade serous ovarian cancer [HGSOC] = 5.5E-4; odds ratio [OR]HGSOC = 5.74 del), and BRCA2 (PHGSOC = 7.0E-4; ORHGSOC = 3.31 deletion). Four suggestive associations (P < .001) were identified for rare CNVs. Risk-associated CNVs were enriched (P < .05) at known EOC risk loci identified by genome-wide association study. Noncoding CNVs were enriched in active promoters and insulators in EOC-related cell types. CONCLUSIONS: CNVs in BRCA1 have been previously reported in smaller studies, but their observed frequency in this large population-based cohort, along with the CNVs observed at BRCA2 and RAD51C gene loci in EOC cases, suggests that these CNVs are potentially pathogenic and may contribute to the spectrum of disease-causing mutations in these genes. CNVs are likely to occur in a wider set of susceptibility regions, with potential implications for clinical genetic testing and disease prevention.
Published: 2022

30. Distinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies

Author: Jung, AY, Ahearn, TU, Behrens, S, Middha, P, Bolla, MK, Wang, Q, Arndt, V, Aronson, KJ, Augustinsson, A, Freeman, LEB, Becher, H, Brenner, H, Canzian, F, Carey, LA, Consortium, C, Czene, K, Eliassen, AH, Eriksson, M, Evans, DG, Figueroa, JD, Fritschi, L, Gabrielson, M, Giles, GG, Guenel, P, Hadjisavvas, A, Haiman, CA, Hakansson, N, Hall, P, Hamann, U, Hoppe, R, Hopper, JL, Howell, A, Hunter, DJ, Huesing, A, Kaaks, R, Kosma, V-M, Koutros, S, Kraft, P, Lacey, J, Le Marchand, L, Lissowska, J, Loizidou, MA, Mannermaa, A, Maurer, T, Murphy, RA, Olshan, AF, Olsson, H, Patel, A, Perou, CM, Rennert, G, Shibli, R, Shu, X-O, Southey, MC, Stone, J, Tamimi, RM, Teras, LR, Troester, MA, Truong, T, Vachon, CM, Wang, SS, Wolk, A, Wu, AH, Yang, XR, Zheng, W, Dunning, AM, Pharoah, PDP, Easton, DF, Milne, RL, Chatterjee, N, Schmidt, MK, Garcia-Closas, M, Chang-Claude, J, Jung, AY, Ahearn, TU, Behrens, S, Middha, P, Bolla, MK, Wang, Q, Arndt, V, Aronson, KJ, Augustinsson, A, Freeman, LEB, Becher, H, Brenner, H, Canzian, F, Carey, LA, Consortium, C, Czene, K, Eliassen, AH, Eriksson, M, Evans, DG, Figueroa, JD, Fritschi, L, Gabrielson, M, Giles, GG, Guenel, P, Hadjisavvas, A, Haiman, CA, Hakansson, N, Hall, P, Hamann, U, Hoppe, R, Hopper, JL, Howell, A, Hunter, DJ, Huesing, A, Kaaks, R, Kosma, V-M, Koutros, S, Kraft, P, Lacey, J, Le Marchand, L, Lissowska, J, Loizidou, MA, Mannermaa, A, Maurer, T, Murphy, RA, Olshan, AF, Olsson, H, Patel, A, Perou, CM, Rennert, G, Shibli, R, Shu, X-O, Southey, MC, Stone, J, Tamimi, RM, Teras, LR, Troester, MA, Truong, T, Vachon, CM, Wang, SS, Wolk, A, Wu, AH, Yang, XR, Zheng, W, Dunning, AM, Pharoah, PDP, Easton, DF, Milne, RL, Chatterjee, N, Schmidt, MK, Garcia-Closas, M, and Chang-Claude, J
Abstract: BACKGROUND: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear. METHODS: Analyses included up to 23 353 cases and 71 072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used to estimate the association between reproductive factors and risk of breast cancer by intrinsic-like subtypes (luminal A-like, luminal B-like, luminal B-HER2-like, HER2-enriched-like, and triple-negative breast cancer) and by invasiveness. All statistical tests were 2-sided. RESULTS: Compared with nulliparous women, parous women had a lower risk of luminal A-like, luminal B-like, luminal B-HER2-like, and HER2-enriched-like disease. This association was apparent only after approximately 10 years since last birth and became stronger with increasing time (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.49 to 0.71; and OR = 0.36, 95% CI = 0.28 to 0.46 for multiparous women with luminal A-like tumors 20 to less than 25 years after last birth and 45 to less than 50 years after last birth, respectively). In contrast, parous women had a higher risk of triple-negative breast cancer right after their last birth (for multiparous women: OR = 3.12, 95% CI = 2.02 to 4.83) that was attenuated with time but persisted for decades (OR = 1.03, 95% CI = 0.79 to 1.34, for multiparous women 25 to less than 30 years after last birth). Older age at first birth (Pheterogeneity < .001 for triple-negative compared with luminal A-like breast cancer) and breastfeeding (Pheterogeneity < .001 for triple-negative compared with luminal A-like breast cancer) were associated with lower risk of triple-negative breast cancer but not with other disease subtypes. Younger age at menarche was associated with higher risk of all
Published: 2022

31. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Author: Dixon-Suen, SC, Lewis, SJ, Martin, RM, English, DR, Boyle, T, Giles, GG, Michailidou, K, Bolla, MK, Wang, Q, Dennis, J, Lush, M, Ahearn, TU, Ambrosone, CB, Andrulis, IL, Anton-Culver, H, Arndt, V, Aronson, KJ, Augustinsson, A, Auvinen, P, Beane Freeman, LE, Becher, H, Beckmann, MW, Behrens, S, Bermisheva, M, Blomqvist, C, Bogdanova, N, Bojesen, SE, Bonanni, B, Brenner, H, Bruening, T, Buys, SS, Camp, NJ, Campa, D, Canzian, F, Castelao, JE, Cessna, MH, Chang-Claude, J, Chanock, SJ, Clarke, CL, Conroy, DM, Couch, FJ, Cox, A, Cross, SS, Czene, K, Daly, MB, Devilee, P, Doerk, T, Dwek, M, Eccles, DM, Eliassen, AH, Engel, C, Eriksson, M, Evans, DG, Fasching, PA, Fletcher, O, Flyger, H, Fritschi, L, Gabrielson, M, Gago-Dominguez, M, Garcia-Closas, M, Garcia-Saenz, JA, Goldberg, MS, Guenel, P, Guendert, M, Hahnen, E, Haiman, CA, Haeberle, L, Hakansson, N, Hall, P, Hamann, U, Hart, SN, Harvie, M, Hillemanns, P, Hollestelle, A, Hooning, MJ, Hoppe, R, Hopper, J, Howell, A, Hunter, DJ, Jakubowska, A, Janni, W, John, EM, Jung, A, Kaaks, R, Keeman, R, Kitahara, CM, Koutros, S, Kraft, P, Kristensen, VN, Kubelka-Sabit, K, Kurian, AW, Lacey, J, Lambrechts, D, Le Marchand, L, Lindblom, A, Loibl, S, Lubinski, J, Mannermaa, A, Manoochehri, M, Margolin, S, Martinez, ME, Mavroudis, D, Menon, U, Mulligan, AM, Murphy, RA, Nevanlinna, H, Nevelsteen, I, Newman, WG, Offit, K, Olshan, AF, Olsson, H, Orr, N, Patel, A, Peto, J, Plaseska-Karanfilska, D, Presneau, N, Rack, B, Radice, P, Rees-Punia, E, Rennert, G, Rennert, HS, Romero, A, Saloustros, E, Sandler, DP, Schmidt, MK, Schmutzler, RK, Schwentner, L, Scott, C, Shah, M, Shu, X-O, Simard, J, Southey, MC, Stone, J, Surowy, H, Swerdlow, AJ, Tamimi, RM, Tapper, WJ, Taylor, JA, Terry, MB, Tollenaar, RAEM, Troester, MA, Truong, T, Untch, M, Vachon, CM, Joseph, V, Wappenschmidt, B, Weinberg, CR, Wolk, A, Yannoukakos, D, Zheng, W, Ziogas, A, Dunning, AM, Pharoah, PDP, Easton, DF, Milne, RL, Lynch, BM, Dixon-Suen, SC, Lewis, SJ, Martin, RM, English, DR, Boyle, T, Giles, GG, Michailidou, K, Bolla, MK, Wang, Q, Dennis, J, Lush, M, Ahearn, TU, Ambrosone, CB, Andrulis, IL, Anton-Culver, H, Arndt, V, Aronson, KJ, Augustinsson, A, Auvinen, P, Beane Freeman, LE, Becher, H, Beckmann, MW, Behrens, S, Bermisheva, M, Blomqvist, C, Bogdanova, N, Bojesen, SE, Bonanni, B, Brenner, H, Bruening, T, Buys, SS, Camp, NJ, Campa, D, Canzian, F, Castelao, JE, Cessna, MH, Chang-Claude, J, Chanock, SJ, Clarke, CL, Conroy, DM, Couch, FJ, Cox, A, Cross, SS, Czene, K, Daly, MB, Devilee, P, Doerk, T, Dwek, M, Eccles, DM, Eliassen, AH, Engel, C, Eriksson, M, Evans, DG, Fasching, PA, Fletcher, O, Flyger, H, Fritschi, L, Gabrielson, M, Gago-Dominguez, M, Garcia-Closas, M, Garcia-Saenz, JA, Goldberg, MS, Guenel, P, Guendert, M, Hahnen, E, Haiman, CA, Haeberle, L, Hakansson, N, Hall, P, Hamann, U, Hart, SN, Harvie, M, Hillemanns, P, Hollestelle, A, Hooning, MJ, Hoppe, R, Hopper, J, Howell, A, Hunter, DJ, Jakubowska, A, Janni, W, John, EM, Jung, A, Kaaks, R, Keeman, R, Kitahara, CM, Koutros, S, Kraft, P, Kristensen, VN, Kubelka-Sabit, K, Kurian, AW, Lacey, J, Lambrechts, D, Le Marchand, L, Lindblom, A, Loibl, S, Lubinski, J, Mannermaa, A, Manoochehri, M, Margolin, S, Martinez, ME, Mavroudis, D, Menon, U, Mulligan, AM, Murphy, RA, Nevanlinna, H, Nevelsteen, I, Newman, WG, Offit, K, Olshan, AF, Olsson, H, Orr, N, Patel, A, Peto, J, Plaseska-Karanfilska, D, Presneau, N, Rack, B, Radice, P, Rees-Punia, E, Rennert, G, Rennert, HS, Romero, A, Saloustros, E, Sandler, DP, Schmidt, MK, Schmutzler, RK, Schwentner, L, Scott, C, Shah, M, Shu, X-O, Simard, J, Southey, MC, Stone, J, Surowy, H, Swerdlow, AJ, Tamimi, RM, Tapper, WJ, Taylor, JA, Terry, MB, Tollenaar, RAEM, Troester, MA, Truong, T, Untch, M, Vachon, CM, Joseph, V, Wappenschmidt, B, Weinberg, CR, Wolk, A, Yannoukakos, D, Zheng, W, Ziogas, A, Dunning, AM, Pharoah, PDP, Easton, DF, Milne, RL, and Lynch, BM
Abstract: OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity. RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer r
Published: 2022

32. The development of the ancient irrigation system at Engaruka, northern Tanzania: physical and societal factors

Author: WESTERBERG, LARS-OVE, HOLMGREN, KARIN, BÖRJESON, LOWE, HÅKANSSON, N THOMAS, LAULUMAA, VESA, RYNER, MARIA, and ÖBERG, HELENA
Published: 2010

33. History and the Problem of Synchronic Models

Author: Håkansson, N. Thomas
Published: 2010
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34. Introduction: Historical and Regional Perspectives on Landscape Transformations in Northeastern Tanzania, 1850-2000

Author: Håkansson, N. Thomas, Widgren, Mats, and Börjeson, Lowe
Published: 2008

35. Arc and Resistance Welding and Tumours of the Endocrine Glands: A Swedish Case-Control Study with Focus on Extremely Low Frequency Magnetic Fields

Author: Håkansson, N., Stenlund, C., Gustavsson, P., Johansen, C., and Floderus, B.
Published: 2005
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36. Cancer Incidence and Magnetic Field Exposure in Industries Using Resistance Welding in Sweden

Author: Håkansson, N., Floderus, B., Gustavsson, P., Johansen, C., and Olsen, J. H.
Published: 2002

37. Grain, Cattle, and Power: Social Processes of Intensive Cultivation and Exchange in Precolonial Western Kenya

Author: Hakansson, N. Thomas
Published: 1994

38. The Detachability of Women: Gender and Kinship in Processes of Socioeconomic Change among the Gusii of Kenya

Author: Hakansson, N. Thomas
Published: 1994

39. An Annotated Checklist of Reptiles Known to Occur in the Gambia

Author: Håkansson, N. Thomas
Published: 1981
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40. CYP3A7*1C allele:linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Author: Johnson, N. (Nichola), Maguire, S. (Sarah), Morra, A. (Anna), Kapoor, P. M. (Pooja Middha), Tomczyk, K. (Katarzyna), Jones, M. E. (Michael E.), Schoemaker, M. J. (Minouk J.), Gilham, C. (Clare), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Baynes, C. (Caroline), Freeman, L. E. (Laura E. Beane), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Bermisheva, M. (Marina), Blomqvist, C. (Carl), Boeckx, B. (Bram), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Clarke, C. L. (Christine L.), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Doerk, T. (Thilo), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Floris, G. (Giuseppe), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gapstur, S. M. (Susan M.), Garcia-Closas, M. (Montserrat), Gaudet, M. M. (Mia M.), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Harrington, P. A. (Patricia A.), Hart, S. N. (Steven N.), Hooning, M. J. (Maartje J.), Hopper, J. L. (John L.), Howell, A. (Anthony), Hunter, D. J. (David J.), Jager, A. (Agnes), Jakubowska, A. (Anna), John, E. M. (Esther M.), Kaaks, R. (Rudolf), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kitahara, C. M. (Cari M.), Kosma, V.-M. (Veli-Matti), Koutros, S. (Stella), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kurian, A. W. (Allison W.), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Linet, M. (Martha), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Martens, J. W. (John W. M.), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Meindl, A. (Alfons), Milne, R. L. (Roger L.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newman, W. G. (William G.), Nielsen, S. F. (Sune F.), Nordestgaard, B. G. (Borge G.), Obi, N. (Nadia), Olshan, A. F. (Andrew F.), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Orban, E. (Ester), Park-Simon, T.-W. (Tjoung-Won), Peterlongo, P. (Paolo), Plaseska-Karanfilska, D. (Dijana), Pylkäs, K. (Katri), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), Ruddy, K. J. (Kathryn J.), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmutzler, R. K. (Rita K.), Scott, C. (Christopher), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Smichkoska, S. (Snezhana), Sohn, C. (Christof), Southey, M. C. (Melissa C.), Spinelli, J. J. (John J.), Stone, J. (Jennifer), Tamimi, R. M. (Rulla M.), Taylor, J. A. (Jack A.), Tollenaar, R. A. (Rob A. E. M.), Tomlinson, I. (Ian), Troester, M. A. (Melissa A.), Truong, T. (Therese), Vachon, C. M. (Celine M.), van Veen, E. M. (Elke M.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Wildiers, H. (Hans), Winqvist, R. (Robert), Wolk, A. (Alicja), Zheng, W. (Wei), Ziogas, A. (Argyrios), Dunning, A. M. (Alison M.), Pharoah, P. D. (Paul D. P.), Easton, D. F. (Douglas F.), Howie, A. F. (A. Forbes), Peto, J. (Julian), dos-Santos-Silva, I. (Isabel), Swerdlow, A. J. (Anthony J.), Chang-Claude, J. (Jenny), Schmidt, M. K. (Marjanka K.), Orr, N. (Nick), and Fletcher, O. (Olivia)
Abstract: Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10⁻¹⁸); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10⁻¹⁸). Conclusions: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.
Published: 2021

41. Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies.

Author: Sinha R., Rohan T.E., Sawada N., Schouten L.J., Stolzenberg-Solomon R.Z., Teras L.R., Tsugane S., Visvanathan K., Weiderpass E., White K.K., Willett W.C., Wolk A., Zeleniuch-Jacquotte A., Smith-Warner S.A., van den Brandt P.A., Ziegler R.G., Wang M., Hou T., Li R., Adami H.-O., Agnoli C., Bernstein L., Buring J.E., Chen Y., Connor A.E., Eliassen A.H., Genkinger J.M., Gierach G., Giles G.G., Goodman G.G., Hakansson N., Krogh V., Le Marchand L., Lee I.-M., Liao L.M., Martinez M.E., Miller A.B., Milne R.L., Neuhouser M.L., Patel A.V., Prizment A., Robien K., Sinha R., Rohan T.E., Sawada N., Schouten L.J., Stolzenberg-Solomon R.Z., Teras L.R., Tsugane S., Visvanathan K., Weiderpass E., White K.K., Willett W.C., Wolk A., Zeleniuch-Jacquotte A., Smith-Warner S.A., van den Brandt P.A., Ziegler R.G., Wang M., Hou T., Li R., Adami H.-O., Agnoli C., Bernstein L., Buring J.E., Chen Y., Connor A.E., Eliassen A.H., Genkinger J.M., Gierach G., Giles G.G., Goodman G.G., Hakansson N., Krogh V., Le Marchand L., Lee I.-M., Liao L.M., Martinez M.E., Miller A.B., Milne R.L., Neuhouser M.L., Patel A.V., Prizment A., and Robien K.
Abstract: Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric factors and risk of premenopausal and postmenopausal BC overall and ER/PR status subtypes were investigated in a pooled analysis of 20 prospective cohorts, including 36,297 BC cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet and other risk factors. We estimated dose-response relationships and tested for nonlinear associations using restricted cubic splines. Height showed positive, linear associations for premenopausal and postmenopausal BC risk (6-7% RR increase per 5 cm increment), with stronger associations for receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated with premenopausal BC risk, and strongly positively-and nonlinearly-associated with postmenopausal BC (especially among women who never used hormone replacement therapy). This was primarily observed for receptor-positive subtypes. Early adult BMI (at 18-20 years) showed inverse, linear associations for premenopausal and postmenopausal BC risk (21% and 11% RR decrease per 5 kg/m2, respectively) with stronger associations for receptor-negative subtypes. Adult weight gain since 18-20 years was positively associated with postmenopausal BC risk, stronger for receptor-positive subtypes, and among women who were leaner in early adulthood. Women heavier in early adulthood generally had reduced premenopausal BC risk, independent of later weight gain. Positive associations between height, baseline (adult) BMI, adult weight gain and postmenopausal BC risk were substantially stronger for hormone receptor-positive versus negative subtypes. Premenopausal BC risk was positively associated with height, but inversely with baseline BMI and weight gain (mostly in receptor-positive subtypes). Inverse associ
Published: 2021

42. Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (Nature Communications, (2021), 12, 1, (1078), 10.1038/s41467-020-20496-3).

Author: Coignard J., Lush M., Beesley J., O'Mara T.A., Dennis J., Tyrer J.P., Barnes D.R., McGuffog L., Leslie G., Bolla M.K., Agata S., Ahearn T., Aittomaki K., Andrulis I.L., Anton-Culver H., Arndt V., Arnold N., Aronson K.J., Arun B.K., Augustinsson A., Azzollini J., Barrowdale D., Baynes C., Becher H., Bermisheva M., Bernstein L., Bialkowska K., Blomqvist C., Bojesen S.E., Bonanni B., Borg A., Brauch H., Brenner H., Burwinkel B., Buys S.S., Caldes T., Caligo M.A., Campa D., Carter B.D., Castelao J.E., Chang-Claude J., Chanock S.J., Chung W.K., Claes K.B.M., Clarke C.L., Bertrand O., Caputo S., Dupre A., Le Mentec M., Belotti M., Birot A.-M., Buecher B., Fourme E., Gauthier-Villars M., Golmard L., Houdayer C., Moncoutier V., de Pauw A., Saule C., Sinilnikova O., Mazoyer S., Damiola F., Barjhoux L., Verny-Pierre C., Leone M., Boutry-Kryza N., Calender A., Giraud S., Caron O., Guillaud-Bataille M., Bressac-de-Paillerets B., Bignon Y.-J., Uhrhammer N., Lasset C., Bonadona V., Berthet P., Vaur D., Castera L., Popovici C., Sobol H., Bourdon V., Noguchi T., Remenieras A., Nogues C., Coupier I., Pujol P., Dumont A., Revillion F., Adenis C., Muller D., Barouk-Simonet E., Bonnet F., Bubien V., Sevenet N., Longy M., Toulas C., Guimbaud R., Gladieff L., Feillel V., Leroux D., Dreyfus H., Rebischung C., Peysselon M., Coron F., Faivre L., Baurand A., Jacquot C., Bertolone G., Lizard S., Prieur F., Lebrun M., Kientz C., Ferrer S.F., Mari V., Venat-Bouvet L., Delnatte C., Bezieau S., Mortemousque I., Coulet F., Colas C., Soubrier F., Warcoin M., Sokolowska J., Bronner M., Collonge-Rame M.-A., Damette A., Gesta P., Lallaoui H., Chiesa J., Molina-Gomes D., Ingster O., Gregory H., Miedzybrodzka Z., Morrison P.J., Ong K.-R., Donaldson A., Rogers M.T., Kennedy M.J., Porteous M.E., Brewer C., Davidson R., Izatt L., Brady A., Barwell J., Adlard J., Foo C., Lalloo F., Side L.E., Eason J., Henderson A., Walker L., Eeles R.A., Cook J., Snape K., Eccles D., Murray A., McCann E., Conroy D.M., Czene K., Daly M.B., Devilee P., Diez O., Ding Y.C., Domchek S.M., Dork T., dos-Santos-Silva I., Dunning A.M., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fostira F., Friedman E., Fritschi L., Frost D., Gago-Dominguez M., Gapstur S.M., Garber J., Garcia-Barberan V., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Gayther S.A., Gehrig A., Georgoulias V., Giles G.G., Godwin A.K., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Greene M.H., Guenel P., Haeberle L., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., He W., Hogervorst F.B.L., Hollestelle A., Hopper J.L., Horcasitas D.J., Hulick P.J., Hunter D.J., Imyanitov E.N., Fox S., Campbell I., Spurdle A., Webb P., de Fazio A., Tassell M., Kirk J., Lindeman G., Price M., Southey M., Milne R., Deb S., Bowtell D., van der Hout A.H., van den Ouweland A.M.W., Mensenkamp A.R., van Deurzen C.H.M., Kets C.M., Seynaeve C., van Asperen C.J., Aalfs C.M., Gomez Garcia E.B., van Leeuwen F.E., de Bock G.H., Meijers-Heijboer H.E.J., Obdeijn I.M., Collee J.M., Gille J.J.P., Oosterwijk J.C., Wijnen J.T., van der Kolk L.E., Hooning M.J., Ausems M.G.E.M., Mourits M.J.E., Blok M.J., Rookus M.A., Adank M.A., van der Luijt R.B., van Cronenburg T.C.T.E.F., van der Pol C.C., Russell N.S., Siesling S., Overbeek L., Wijnands R., de Lange J.L., Clarke C., Graham D., Sachchithananthan M., Marsh D., Scott R., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Simpson P., Jager A., Jakubowska A., James P.A., Jensen U.B., John E.M., Jones M.E., Kaaks R., Kapoor P.M., Karlan B.Y., Keeman R., Khusnutdinova E., Kiiski J.I., Ko Y.-D., Kosma V.-M., Kraft P., Kurian A.W., Laitman Y., Lambrechts D., Le Marchand L., Lester J., Lesueur F., Lindstrom T., Lopez-Fernandez A., Loud J.T., Luccarini C., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mebirouk N., Meindl A., Miller A., Milne R.L., Montagna M., Nathanson K.L., Neuhausen S.L., Nevanlinna H., Nielsen F.C., O'Brien K.M., Olopade O.I., Olson J.E., Olsson H., Osorio A., Ottini L., Park-Simon T.-W., Parsons M.T., Pedersen I.S., Peshkin B., Peterlongo P., Peto J., Pharoah P.D.P., Phillips K.-A., Polley E.C., Poppe B., Presneau N., Pujana M.A., Punie K., Radice P., Rantala J., Rashid M.U., Rennert G., Rennert H.S., Robson M., Romero A., Rossing M., Saloustros E., Sandler D.P., Santella R., Scheuner M.T., Schmidt M.K., Schmidt G., Scott C., Sharma P., Soucy P., Southey M.C., Spinelli J.J., Steinsnyder Z., Stone J., Stoppa-Lyonnet D., Swerdlow A., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Teule A., Thull D.L., Tischkowitz M., Toland A.E., Torres D., Trainer A.H., Truong T., Tung N., Vachon C.M., Vega A., Vijai J., Wang Q., Wappenschmidt B., Weinberg C.R., Weitzel J.N., Wendt C., Wolk A., Yadav S., Yang X.R., Yannoukakos D., Zheng W., Ziogas A., Zorn K.K., Park S.K., Thomassen M., Offit K., Schmutzler R.K., Couch F.J., Simard J., Chenevix-Trench G., Easton D.F., Andrieu N., Antoniou A.C., Coignard J., Lush M., Beesley J., O'Mara T.A., Dennis J., Tyrer J.P., Barnes D.R., McGuffog L., Leslie G., Bolla M.K., Agata S., Ahearn T., Aittomaki K., Andrulis I.L., Anton-Culver H., Arndt V., Arnold N., Aronson K.J., Arun B.K., Augustinsson A., Azzollini J., Barrowdale D., Baynes C., Becher H., Bermisheva M., Bernstein L., Bialkowska K., Blomqvist C., Bojesen S.E., Bonanni B., Borg A., Brauch H., Brenner H., Burwinkel B., Buys S.S., Caldes T., Caligo M.A., Campa D., Carter B.D., Castelao J.E., Chang-Claude J., Chanock S.J., Chung W.K., Claes K.B.M., Clarke C.L., Bertrand O., Caputo S., Dupre A., Le Mentec M., Belotti M., Birot A.-M., Buecher B., Fourme E., Gauthier-Villars M., Golmard L., Houdayer C., Moncoutier V., de Pauw A., Saule C., Sinilnikova O., Mazoyer S., Damiola F., Barjhoux L., Verny-Pierre C., Leone M., Boutry-Kryza N., Calender A., Giraud S., Caron O., Guillaud-Bataille M., Bressac-de-Paillerets B., Bignon Y.-J., Uhrhammer N., Lasset C., Bonadona V., Berthet P., Vaur D., Castera L., Popovici C., Sobol H., Bourdon V., Noguchi T., Remenieras A., Nogues C., Coupier I., Pujol P., Dumont A., Revillion F., Adenis C., Muller D., Barouk-Simonet E., Bonnet F., Bubien V., Sevenet N., Longy M., Toulas C., Guimbaud R., Gladieff L., Feillel V., Leroux D., Dreyfus H., Rebischung C., Peysselon M., Coron F., Faivre L., Baurand A., Jacquot C., Bertolone G., Lizard S., Prieur F., Lebrun M., Kientz C., Ferrer S.F., Mari V., Venat-Bouvet L., Delnatte C., Bezieau S., Mortemousque I., Coulet F., Colas C., Soubrier F., Warcoin M., Sokolowska J., Bronner M., Collonge-Rame M.-A., Damette A., Gesta P., Lallaoui H., Chiesa J., Molina-Gomes D., Ingster O., Gregory H., Miedzybrodzka Z., Morrison P.J., Ong K.-R., Donaldson A., Rogers M.T., Kennedy M.J., Porteous M.E., Brewer C., Davidson R., Izatt L., Brady A., Barwell J., Adlard J., Foo C., Lalloo F., Side L.E., Eason J., Henderson A., Walker L., Eeles R.A., Cook J., Snape K., Eccles D., Murray A., McCann E., Conroy D.M., Czene K., Daly M.B., Devilee P., Diez O., Ding Y.C., Domchek S.M., Dork T., dos-Santos-Silva I., Dunning A.M., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fostira F., Friedman E., Fritschi L., Frost D., Gago-Dominguez M., Gapstur S.M., Garber J., Garcia-Barberan V., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Gayther S.A., Gehrig A., Georgoulias V., Giles G.G., Godwin A.K., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Greene M.H., Guenel P., Haeberle L., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., He W., Hogervorst F.B.L., Hollestelle A., Hopper J.L., Horcasitas D.J., Hulick P.J., Hunter D.J., Imyanitov E.N., Fox S., Campbell I., Spurdle A., Webb P., de Fazio A., Tassell M., Kirk J., Lindeman G., Price M., Southey M., Milne R., Deb S., Bowtell D., van der Hout A.H., van den Ouweland A.M.W., Mensenkamp A.R., van Deurzen C.H.M., Kets C.M., Seynaeve C., van Asperen C.J., Aalfs C.M., Gomez Garcia E.B., van Leeuwen F.E., de Bock G.H., Meijers-Heijboer H.E.J., Obdeijn I.M., Collee J.M., Gille J.J.P., Oosterwijk J.C., Wijnen J.T., van der Kolk L.E., Hooning M.J., Ausems M.G.E.M., Mourits M.J.E., Blok M.J., Rookus M.A., Adank M.A., van der Luijt R.B., van Cronenburg T.C.T.E.F., van der Pol C.C., Russell N.S., Siesling S., Overbeek L., Wijnands R., de Lange J.L., Clarke C., Graham D., Sachchithananthan M., Marsh D., Scott R., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Simpson P., Jager A., Jakubowska A., James P.A., Jensen U.B., John E.M., Jones M.E., Kaaks R., Kapoor P.M., Karlan B.Y., Keeman R., Khusnutdinova E., Kiiski J.I., Ko Y.-D., Kosma V.-M., Kraft P., Kurian A.W., Laitman Y., Lambrechts D., Le Marchand L., Lester J., Lesueur F., Lindstrom T., Lopez-Fernandez A., Loud J.T., Luccarini C., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mebirouk N., Meindl A., Miller A., Milne R.L., Montagna M., Nathanson K.L., Neuhausen S.L., Nevanlinna H., Nielsen F.C., O'Brien K.M., Olopade O.I., Olson J.E., Olsson H., Osorio A., Ottini L., Park-Simon T.-W., Parsons M.T., Pedersen I.S., Peshkin B., Peterlongo P., Peto J., Pharoah P.D.P., Phillips K.-A., Polley E.C., Poppe B., Presneau N., Pujana M.A., Punie K., Radice P., Rantala J., Rashid M.U., Rennert G., Rennert H.S., Robson M., Romero A., Rossing M., Saloustros E., Sandler D.P., Santella R., Scheuner M.T., Schmidt M.K., Schmidt G., Scott C., Sharma P., Soucy P., Southey M.C., Spinelli J.J., Steinsnyder Z., Stone J., Stoppa-Lyonnet D., Swerdlow A., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Teule A., Thull D.L., Tischkowitz M., Toland A.E., Torres D., Trainer A.H., Truong T., Tung N., Vachon C.M., Vega A., Vijai J., Wang Q., Wappenschmidt B., Weinberg C.R., Weitzel J.N., Wendt C., Wolk A., Yadav S., Yang X.R., Yannoukakos D., Zheng W., Ziogas A., Zorn K.K., Park S.K., Thomassen M., Offit K., Schmutzler R.K., Couch F.J., Simard J., Chenevix-Trench G., Easton D.F., Andrieu N., and Antoniou A.C.
Abstract: The original version of this Article contained an error in the spelling of the author Heiko Becher, which was incorrectly given as Heko Becher. This has now been corrected in both the PDF and HTML versions of the Article.Copyright © 2021, The Author(s).
Published: 2021

43. Ovarian cancer risk factor associations by primary anatomic site: The ovarian cancer cohort consortium.

Author: Fortner R.T., Rice M.S., Knutsen S.F., Orlich M.J., Visvanathan K., Patel A.V., Gaudet M.M., Tjonneland A., Kvaskoff M., Kaaks R., Trichopolou A., Pala V., Charlotte Onland-Moret N., Gram I.T., Amiano P., Idahl A., Allen N.E., Weiderpass E., Poynter J.N., Robien K., Giles G.G., Milne R.L., Setiawan V.W., Merritt M.A., Van Den Brandt P.A., Zeleniuch-Jacquotte A., Arslan A.A., O'Brien K.M., Sandler D.P., Wolk A., Hakansson N., Harris H.R., Trabert B., Wentzensen N., Tworoger S.S., Schouten L.J., Fortner R.T., Rice M.S., Knutsen S.F., Orlich M.J., Visvanathan K., Patel A.V., Gaudet M.M., Tjonneland A., Kvaskoff M., Kaaks R., Trichopolou A., Pala V., Charlotte Onland-Moret N., Gram I.T., Amiano P., Idahl A., Allen N.E., Weiderpass E., Poynter J.N., Robien K., Giles G.G., Milne R.L., Setiawan V.W., Merritt M.A., Van Den Brandt P.A., Zeleniuch-Jacquotte A., Arslan A.A., O'Brien K.M., Sandler D.P., Wolk A., Hakansson N., Harris H.R., Trabert B., Wentzensen N., Tworoger S.S., and Schouten L.J.
Abstract: Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Method(s): We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Result(s): Most associations did not vary by tumor site (Phet >= 0.05). Associations between first pregnancy (Phet 1/4 0.04), tubal ligation (Phet 1/4 0.01), and early-adult (age 18-21 years) body mass index (BMI; Phet 1/4 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (Phet 1/4 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusion(s): Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.Copyright © 2020 American Association for Cancer Research.
Published: 2021

44. Breast cancer risk factors and survival by tumor subtype: Pooled analyses from the breast cancer association consortium.

Author: Morra A., Jung A.Y., Behrens S., Keeman R., Ahearn T.U., Anton-Culver H., Arndt V., Augustinsson A., Auvinen P.K., Beane Freeman L.E., Becher H., Beckmann M.W., Blomqvist C., Bojesen S.E., Bolla M.K., Brenner H., Briceno I., Brucker S.Y., Camp N.J., Campa D., Canzian F., Castelao J.E., Chanock S.J., Choi J.-Y., Clarke C.L., Couch F.J., Cox A., Cross S.S., Czene K., Dork T., Dunning A.M., Dwek M., Easton D.F., Eccles D.M., Egan K.M., Evans D.G., Fasching P.A., Flyger H., Gago-Dominguez M., Gapstur S.M., Garcia-Saenz J.A., Gaudet M.M., Giles G.G., Grip M., Guenel P., Haiman C.A., Hakansson N., Hall P., Hamann U., Han S.N., Hart S.N., Hartman M., Heyworth J.S., Hoppe R., Hopper J.L., Hunter D.J., Ito H., Jager A., Jakimovska M., Jakubowska A., Janni W., Kaaks R., Kang D., Kapoor P.M., Kitahara C.M., Koutros S., Kraft P., Kristensen V.N., Lacey J.V., Lambrechts D., Le Marchand L., Li J., Lindblom A., Lubi-Nski J., Lush M., Mannermaa A., Manoochehri M., Margolin S., Mariapun S., Matsuo K., Mavroudis D., Milne R.L., Muranen T.A., Newman W.G., Noh D.-Y., Nordestgaard B.G., Obi N., Olshan A.F., Olsson H., Park-Simon T.-W., Petridis C., Pharoah P.D.P., Plaseska-Karanfilska D., Presneau N., Rashid M.U., Rennert G., Rennert H.S., Rhenius V., Romero A., Saloustros E., Sawyer E.J., Schneeweiss A., Schwentner L., Scott C., Shah M., Shen C.-Y., Shu X.-O., Southey M.C., Stram D.O., Tamimi R.M., Tapper W., Tollenaar R.A.E.M., Tomlinson I., Torres D., Troester M.A., Therese Truong, Vachon C.M., Wang Q., Wang S.S., Williams J.A., Winqvist R., Wolk A., Wu A.H., Yoo K.-Y., Yu J.-C., Zheng W., Ziogas A., Yang X.R., Eliassen A.H., Holmes M.D., Garcia-Closas M., Teo S.H., Schmidt M.K., Chang-Claude J., Morra A., Jung A.Y., Behrens S., Keeman R., Ahearn T.U., Anton-Culver H., Arndt V., Augustinsson A., Auvinen P.K., Beane Freeman L.E., Becher H., Beckmann M.W., Blomqvist C., Bojesen S.E., Bolla M.K., Brenner H., Briceno I., Brucker S.Y., Camp N.J., Campa D., Canzian F., Castelao J.E., Chanock S.J., Choi J.-Y., Clarke C.L., Couch F.J., Cox A., Cross S.S., Czene K., Dork T., Dunning A.M., Dwek M., Easton D.F., Eccles D.M., Egan K.M., Evans D.G., Fasching P.A., Flyger H., Gago-Dominguez M., Gapstur S.M., Garcia-Saenz J.A., Gaudet M.M., Giles G.G., Grip M., Guenel P., Haiman C.A., Hakansson N., Hall P., Hamann U., Han S.N., Hart S.N., Hartman M., Heyworth J.S., Hoppe R., Hopper J.L., Hunter D.J., Ito H., Jager A., Jakimovska M., Jakubowska A., Janni W., Kaaks R., Kang D., Kapoor P.M., Kitahara C.M., Koutros S., Kraft P., Kristensen V.N., Lacey J.V., Lambrechts D., Le Marchand L., Li J., Lindblom A., Lubi-Nski J., Lush M., Mannermaa A., Manoochehri M., Margolin S., Mariapun S., Matsuo K., Mavroudis D., Milne R.L., Muranen T.A., Newman W.G., Noh D.-Y., Nordestgaard B.G., Obi N., Olshan A.F., Olsson H., Park-Simon T.-W., Petridis C., Pharoah P.D.P., Plaseska-Karanfilska D., Presneau N., Rashid M.U., Rennert G., Rennert H.S., Rhenius V., Romero A., Saloustros E., Sawyer E.J., Schneeweiss A., Schwentner L., Scott C., Shah M., Shen C.-Y., Shu X.-O., Southey M.C., Stram D.O., Tamimi R.M., Tapper W., Tollenaar R.A.E.M., Tomlinson I., Torres D., Troester M.A., Therese Truong, Vachon C.M., Wang Q., Wang S.S., Williams J.A., Winqvist R., Wolk A., Wu A.H., Yoo K.-Y., Yu J.-C., Zheng W., Ziogas A., Yang X.R., Eliassen A.H., Holmes M.D., Garcia-Closas M., Teo S.H., Schmidt M.K., and Chang-Claude J.
Abstract: Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. Method(s): We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer. specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype. Result(s): There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI >=30 versus 18.5.25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age >=30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0.<5 years versus >=10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen.progestin therapy [0.61 (0.54.0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking. Conclusion(s): We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype. Impact: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.Copyright © 2021 American Association for Cancer Research.
Published: 2021

45. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (Nature Genetics, (2021), 53, 1, (65-75), 10.1038/s41588-020-00748-0).

Author: Lessel D., Townsend P.A., Aukim-Hastie C., Bush W.S., Aldrich M.C., Crawford D.C., Srivastava S., Cullen J.C., Petrovics G., Casey G., Roobol M.J., Jenster G., van Schaik R.H.N., Hu J.J., Sanderson M., Varma R., McKean-Cowdin R., Torres M., Mancuso N., Berndt S.I., Van Den Eeden S.K., Easton D.F., Chanock S.J., Cook M.B., Wiklund F., Nakagawa H., Witte J.S., Eeles R.A., Kote-Jarai Z., Haiman C.A., Conti D.V., Darst B.F., Moss L.C., Saunders E.J., Sheng X., Chou A., Schumacher F.R., Olama A.A.A., Benlloch S., Dadaev T., Brook M.N., Sahimi A., Hoffmann T.J., Takahashi A., Matsuda K., Momozawa Y., Fujita M., Muir K., Lophatananon A., Wan P., Le Marchand L., Wilkens L.R., Stevens V.L., Gapstur S.M., Carter B.D., Schleutker J., Tammela T.L.J., Sipeky C., Auvinen A., Giles G.G., Southey M.C., MacInnis R.J., Cybulski C., Wokolorczyk D., Lubinski J., Neal D.E., Donovan J.L., Hamdy F.C., Martin R.M., Nordestgaard B.G., Nielsen S.F., Weischer M., Bojesen S.E., Roder M.A., Iversen P., Batra J., Chambers S., Moya L., Horvath L., Clements J.A., Tilley W., Risbridger G.P., Gronberg H., Aly M., Szulkin R., Eklund M., Nordstrom T., Pashayan N., Dunning A.M., Ghoussaini M., Travis R.C., Key T.J., Riboli E., Park J.Y., Sellers T.A., Lin H.-Y., Albanes D., Weinstein S.J., Mucci L.A., Giovannucci E., Lindstrom S., Kraft P., Hunter D.J., Penney K.L., Turman C., Tangen C.M., Goodman P.J., Thompson I.M., Hamilton R.J., Fleshner N.E., Finelli A., Parent M.-E., Stanford J.L., Ostrander E.A., Geybels M.S., Koutros S., Freeman L.E.B., Stampfer M., Wolk A., Hakansson N., Andriole G.L., Hoover R.N., Machiela M.J., Sorensen K.D., Borre M., Blot W.J., Zheng W., Yeboah E.D., Mensah J.E., Lu Y.-J., Zhang H.-W., Feng N., Mao X., Wu Y., Zhao S.-C., Sun Z., Thibodeau S.N., McDonnell S.K., Schaid D.J., West C.M.L., Burnet N., Barnett G., Maier C., Schnoeller T., Luedeke M., Kibel A.S., Drake B.F., Cussenot O., Cancel-Tassin G., Menegaux F., Truong T., Koudou Y.A., John E.M., Grindedal E.M., Maehle L., Khaw K.-T., Ingles S.A., Stern M.C., Vega A., Gomez-Caamano A., Fachal L., Rosenstein B.S., Kerns S.L., Ostrer H., Teixeira M.R., Paulo P., Brandao A., Watya S., Lubwama A., Bensen J.T., Fontham E.T.H., Mohler J., Taylor J.A., Kogevinas M., Llorca J., Castano-Vinyals G., Cannon-Albright L., Teerlink C.C., Huff C.D., Strom S.S., Multigner L., Blanchet P., Brureau L., Kaneva R., Slavov C., Mitev V., Leach R.J., Weaver B., Brenner H., Cuk K., Holleczek B., Saum K.-U., Klein E.A., Hsing A.W., Kittles R.A., Murphy A.B., Logothetis C.J., Kim J., Neuhausen S.L., Steele L., Ding Y.C., Isaacs W.B., Nemesure B., Hennis A.J.M., Carpten J., Pandha H., Michael A., De Ruyck K., De Meerleer G., Ost P., Xu J., Razack A., Lim J., Teo S.-H., Newcomb L.F., Lin D.W., Fowke J.H., Neslund-Dudas C., Rybicki B.A., Gamulin M., Kulis T., Usmani N., Singhal S., Parliament M., Claessens F., Joniau S., Van den Broeck T., Gago-Dominguez M., Castelao J.E., Martinez M.E., Larkin S., Lessel D., Townsend P.A., Aukim-Hastie C., Bush W.S., Aldrich M.C., Crawford D.C., Srivastava S., Cullen J.C., Petrovics G., Casey G., Roobol M.J., Jenster G., van Schaik R.H.N., Hu J.J., Sanderson M., Varma R., McKean-Cowdin R., Torres M., Mancuso N., Berndt S.I., Van Den Eeden S.K., Easton D.F., Chanock S.J., Cook M.B., Wiklund F., Nakagawa H., Witte J.S., Eeles R.A., Kote-Jarai Z., Haiman C.A., Conti D.V., Darst B.F., Moss L.C., Saunders E.J., Sheng X., Chou A., Schumacher F.R., Olama A.A.A., Benlloch S., Dadaev T., Brook M.N., Sahimi A., Hoffmann T.J., Takahashi A., Matsuda K., Momozawa Y., Fujita M., Muir K., Lophatananon A., Wan P., Le Marchand L., Wilkens L.R., Stevens V.L., Gapstur S.M., Carter B.D., Schleutker J., Tammela T.L.J., Sipeky C., Auvinen A., Giles G.G., Southey M.C., MacInnis R.J., Cybulski C., Wokolorczyk D., Lubinski J., Neal D.E., Donovan J.L., Hamdy F.C., Martin R.M., Nordestgaard B.G., Nielsen S.F., Weischer M., Bojesen S.E., Roder M.A., Iversen P., Batra J., Chambers S., Moya L., Horvath L., Clements J.A., Tilley W., Risbridger G.P., Gronberg H., Aly M., Szulkin R., Eklund M., Nordstrom T., Pashayan N., Dunning A.M., Ghoussaini M., Travis R.C., Key T.J., Riboli E., Park J.Y., Sellers T.A., Lin H.-Y., Albanes D., Weinstein S.J., Mucci L.A., Giovannucci E., Lindstrom S., Kraft P., Hunter D.J., Penney K.L., Turman C., Tangen C.M., Goodman P.J., Thompson I.M., Hamilton R.J., Fleshner N.E., Finelli A., Parent M.-E., Stanford J.L., Ostrander E.A., Geybels M.S., Koutros S., Freeman L.E.B., Stampfer M., Wolk A., Hakansson N., Andriole G.L., Hoover R.N., Machiela M.J., Sorensen K.D., Borre M., Blot W.J., Zheng W., Yeboah E.D., Mensah J.E., Lu Y.-J., Zhang H.-W., Feng N., Mao X., Wu Y., Zhao S.-C., Sun Z., Thibodeau S.N., McDonnell S.K., Schaid D.J., West C.M.L., Burnet N., Barnett G., Maier C., Schnoeller T., Luedeke M., Kibel A.S., Drake B.F., Cussenot O., Cancel-Tassin G., Menegaux F., Truong T., Koudou Y.A., John E.M., Grindedal E.M., Maehle L., Khaw K.-T., Ingles S.A., Stern M.C., Vega A., Gomez-Caamano A., Fachal L., Rosenstein B.S., Kerns S.L., Ostrer H., Teixeira M.R., Paulo P., Brandao A., Watya S., Lubwama A., Bensen J.T., Fontham E.T.H., Mohler J., Taylor J.A., Kogevinas M., Llorca J., Castano-Vinyals G., Cannon-Albright L., Teerlink C.C., Huff C.D., Strom S.S., Multigner L., Blanchet P., Brureau L., Kaneva R., Slavov C., Mitev V., Leach R.J., Weaver B., Brenner H., Cuk K., Holleczek B., Saum K.-U., Klein E.A., Hsing A.W., Kittles R.A., Murphy A.B., Logothetis C.J., Kim J., Neuhausen S.L., Steele L., Ding Y.C., Isaacs W.B., Nemesure B., Hennis A.J.M., Carpten J., Pandha H., Michael A., De Ruyck K., De Meerleer G., Ost P., Xu J., Razack A., Lim J., Teo S.-H., Newcomb L.F., Lin D.W., Fowke J.H., Neslund-Dudas C., Rybicki B.A., Gamulin M., Kulis T., Usmani N., Singhal S., Parliament M., Claessens F., Joniau S., Van den Broeck T., Gago-Dominguez M., Castelao J.E., Martinez M.E., and Larkin S.
Abstract: In the version of this article originally published, the names of the equally contributing authors and jointly supervising authors were switched. The correct affiliations are: "These authors contributed equally: David V. Conti, Burcu F. Darst. These authors jointly supervised this work: David V. Conti, Rosalind A. Eeles, Zsofia Kote-Jarai, Christopher A. Haiman." The error has been corrected in the HTML and PDF versions of the article.Copyright © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Published: 2021

46. Mendelian randomisation study of smoking exposure in relation to breast cancer risk.

Author: Park H.A., Neumeyer S., Michailidou K., Bolla M.K., Wang Q., Dennis J., Ahearn T.U., Andrulis I.L., Anton-Culver H., Antonenkova N.N., Arndt V., Aronson K.J., Augustinsson A., Baten A., Beane Freeman L.E., Becher H., Beckmann M.W., Behrens S., Benitez J., Bermisheva M., Bogdanova N.V., Bojesen S.E., Brauch H., Brenner H., Brucker S.Y., Burwinkel B., Campa D., Canzian F., Castelao J.E., Chanock S.J., Clarke C.L., Borresen-Dale A.-L., Grenaker Alnaes G.I., Sahlberg K.K., Ottestad L., Karesen R., Schlichting E., Holmen M.M., Sauer T., Haakensen V., Engebraten O., Naume B., Fossa A., Kiserud C.E., Reinertsen K.V., Helland A., Riis M., Geisler J., Conroy D.M., Couch F.J., Cox A., Cross S.S., Czene K., Daly M.B., Devilee P., Dork T., dos-Santos-Silva I., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fritschi L., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Giles G.G., Glendon G., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Grip M., Guenel P., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Han S., Harkness E.F., Hart S.N., He W., Heemskerk-Gerritsen B.A.M., Hopper J.L., Hunter D.J., Clarke C., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Graham D., Sachchithananthan M., Amor D., Andrews L., Antill Y., Balleine R., Beesley J., Bennett I., Bogwitz M., Botes L., Brennan M., Brown M., Buckley M., Burke J., Butow P., Caldon L., Campbell I., Chauhan D., Chauhan M., Chenevix-Trench G., Christian A., Cohen P., Colley A., Crook A., Cui J., Cummings M., Dawson S.-J., DeFazio A., Delatycki M., Dickson R., Dixon J., Edkins T., Edwards S., Farshid G., Fellows A., Fenton G., Field M., Flanagan J., Fong P., Forrest L., Fox S., French J., Friedlander M., Gaff C., Gattas M., George P., Greening S., Harris M., Hart S., Hayward N., Hopper J., Hoskins C., Hunt C., James P., Jenkins M., Kidd A., Kirk J., Koehler J., Kollias J., Lakhani S., Lawrence M., Lindeman G., Lipton L., Lobb L., Mann G., Marsh D., McLachlan S.A., Meiser B., Milne R., Nightingale S., O'Connell S., O'Sullivan S., Ortega D.G., Pachter N., Patterson B., Pearn A., Phillips K., Pieper E., Rickard E., Robinson B., Saleh M., Salisbury E., Saunders C., Saunus J., Scott R., Sexton A., Shelling A., Simpson P., Southey M., Spurdle A., Taylor J., Taylor R., Thorne H., Trainer A., Tucker K., Visvader J., Walker L., Williams R., Winship I., Young M.A., Jager A., Jakubowska A., John E.M., Jung A., Kaaks R., Kapoor P.M., Keeman R., Khusnutdinova E., Kitahara C.M., Koppert L.B., Koutros S., Kristensen V.N., Kurian A.W., Lacey J., Lambrechts D., Le Marchand L., Lo W.-Y., Lubinski J., Mannermaa A., Manoochehri M., Margolin S., Martinez M.E., Mavroudis D., Meindl A., Menon U., Milne R.L., Muranen T.A., Nevanlinna H., Newman W.G., Nordestgaard B.G., Offit K., Olshan A.F., Olsson H., Park-Simon T.-W., Peterlongo P., Peto J., Plaseska-Karanfilska D., Presneau N., Radice P., Rennert G., Rennert H.S., Romero A., Saloustros E., Sawyer E.J., Schmidt M.K., Schmutzler R.K., Schoemaker M.J., Schwentner L., Scott C., Shah M., Shu X.-O., Simard J., Smeets A., Southey M.C., Spinelli J.J., Stevens V., Swerdlow A.J., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Tomlinson I., Troester M.A., Truong T., Vachon C.M., van Veen E.M., Vijai J., Wang S., Wendt C., Winqvist R., Wolk A., Ziogas A., Dunning A.M., Pharoah P.D.P., Easton D.F., Zheng W., Kraft P., Chang-Claude J., Park H.A., Neumeyer S., Michailidou K., Bolla M.K., Wang Q., Dennis J., Ahearn T.U., Andrulis I.L., Anton-Culver H., Antonenkova N.N., Arndt V., Aronson K.J., Augustinsson A., Baten A., Beane Freeman L.E., Becher H., Beckmann M.W., Behrens S., Benitez J., Bermisheva M., Bogdanova N.V., Bojesen S.E., Brauch H., Brenner H., Brucker S.Y., Burwinkel B., Campa D., Canzian F., Castelao J.E., Chanock S.J., Clarke C.L., Borresen-Dale A.-L., Grenaker Alnaes G.I., Sahlberg K.K., Ottestad L., Karesen R., Schlichting E., Holmen M.M., Sauer T., Haakensen V., Engebraten O., Naume B., Fossa A., Kiserud C.E., Reinertsen K.V., Helland A., Riis M., Geisler J., Conroy D.M., Couch F.J., Cox A., Cross S.S., Czene K., Daly M.B., Devilee P., Dork T., dos-Santos-Silva I., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fritschi L., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Giles G.G., Glendon G., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Grip M., Guenel P., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Han S., Harkness E.F., Hart S.N., He W., Heemskerk-Gerritsen B.A.M., Hopper J.L., Hunter D.J., Clarke C., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Graham D., Sachchithananthan M., Amor D., Andrews L., Antill Y., Balleine R., Beesley J., Bennett I., Bogwitz M., Botes L., Brennan M., Brown M., Buckley M., Burke J., Butow P., Caldon L., Campbell I., Chauhan D., Chauhan M., Chenevix-Trench G., Christian A., Cohen P., Colley A., Crook A., Cui J., Cummings M., Dawson S.-J., DeFazio A., Delatycki M., Dickson R., Dixon J., Edkins T., Edwards S., Farshid G., Fellows A., Fenton G., Field M., Flanagan J., Fong P., Forrest L., Fox S., French J., Friedlander M., Gaff C., Gattas M., George P., Greening S., Harris M., Hart S., Hayward N., Hopper J., Hoskins C., Hunt C., James P., Jenkins M., Kidd A., Kirk J., Koehler J., Kollias J., Lakhani S., Lawrence M., Lindeman G., Lipton L., Lobb L., Mann G., Marsh D., McLachlan S.A., Meiser B., Milne R., Nightingale S., O'Connell S., O'Sullivan S., Ortega D.G., Pachter N., Patterson B., Pearn A., Phillips K., Pieper E., Rickard E., Robinson B., Saleh M., Salisbury E., Saunders C., Saunus J., Scott R., Sexton A., Shelling A., Simpson P., Southey M., Spurdle A., Taylor J., Taylor R., Thorne H., Trainer A., Tucker K., Visvader J., Walker L., Williams R., Winship I., Young M.A., Jager A., Jakubowska A., John E.M., Jung A., Kaaks R., Kapoor P.M., Keeman R., Khusnutdinova E., Kitahara C.M., Koppert L.B., Koutros S., Kristensen V.N., Kurian A.W., Lacey J., Lambrechts D., Le Marchand L., Lo W.-Y., Lubinski J., Mannermaa A., Manoochehri M., Margolin S., Martinez M.E., Mavroudis D., Meindl A., Menon U., Milne R.L., Muranen T.A., Nevanlinna H., Newman W.G., Nordestgaard B.G., Offit K., Olshan A.F., Olsson H., Park-Simon T.-W., Peterlongo P., Peto J., Plaseska-Karanfilska D., Presneau N., Radice P., Rennert G., Rennert H.S., Romero A., Saloustros E., Sawyer E.J., Schmidt M.K., Schmutzler R.K., Schoemaker M.J., Schwentner L., Scott C., Shah M., Shu X.-O., Simard J., Smeets A., Southey M.C., Spinelli J.J., Stevens V., Swerdlow A.J., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Tomlinson I., Troester M.A., Truong T., Vachon C.M., van Veen E.M., Vijai J., Wang S., Wendt C., Winqvist R., Wolk A., Ziogas A., Dunning A.M., Pharoah P.D.P., Easton D.F., Zheng W., Kraft P., and Chang-Claude J.
Abstract: Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Method(s): We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Result(s): Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 x 10-2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion(s): Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.Copyright © 2021, The Author(s).
Published: 2021

47. Genetic insights into biological mechanisms governing human ovarian ageing.

Author: Ruth K.S., Day F.R., Hussain J., Martinez-Marchal A., Aiken C.E., Azad A., Thompson D.J., Knoblochova L., Abe H., Tarry-Adkins J.L., Gonzalez J.M., Fontanillas P., Claringbould A., Bakker O.B., Sulem P., Walters R.G., Terao C., Turon S., Horikoshi M., Lin K., Onland-Moret N.C., Sankar A., Hertz E.P.T., Timshel P.N., Shukla V., Borup R., Olsen K.W., Aguilera P., Ferrer-Roda M., Huang Y., Stankovic S., Timmers P.R.H.J., Ahearn T.U., Alizadeh B.Z., Naderi E., Andrulis I.L., Arnold A.M., Aronson K.J., Augustinsson A., Bandinelli S., Barbieri C.M., Beaumont R.N., Becher H., Beckmann M.W., Benonisdottir S., Bergmann S., Bochud M., Boerwinkle E., Bojesen S.E., Bolla M.K., Boomsma D.I., Bowker N., Brody J.A., Broer L., Buring J.E., Campbell A., Campbell H., Castelao J.E., Catamo E., Chanock S.J., Chenevix-Trench G., Ciullo M., Corre T., Couch F.J., Cox A., Crisponi L., Cross S.S., Cucca F., Czene K., Smith G.D., de Geus E.J.C.N., de Mutsert R., De Vivo I., Demerath E.W., Dennis J., Dunning A.M., Dwek M., Eriksson M., Esko T., Fasching P.A., Faul J.D., Ferrucci L., Franceschini N., Frayling T.M., Gago-Dominguez M., Mezzavilla M., Garcia-Closas M., Gieger C., Giles G.G., Grallert H., Gudbjartsson D.F., Gudnason V., Guenel P., Haiman C.A., Hakansson N., Hall P., Hayward C., He C., He W., Heiss G., Hoffding M.K., Hopper J.L., Hottenga J.J., Hu F., Hunter D., Ikram M.A., Jackson R.D., Joaquim M.D.R., John E.M., Joshi P.K., Karasik D., Kardia S.L.R., Kartsonaki C., Karlsson R., Kitahara C.M., Kolcic I., Kooperberg C., Kraft P., Kurian A.W., Kutalik Z., La Bianca M., LaChance G., Langenberg C., Launer L.J., Laven J.S.E., Lawlor D.A., Le Marchand L., Li J., Lindblom A., Lindstrom S., Lindstrom T., Linet M., Liu Y.M., Liu S., Luan J., Magi R., Magnusson P.K.E., Mangino M., Mannermaa A., Marco B., Marten J., Martin N.G., Mbarek H., McKnight B., Medland S.E., Meisinger C., Meitinger T., Menni C., Metspalu A., Milani L., Milne R.L., Montgomery G.W., Mook-Kanamori D.O., Mulas A., Mulligan A.M., Nalls M.A., Newman A., Noordam R., Nutile T., Nyholt D.R., Olshan A.F., Olsson H., Painter J.N., Patel A.V., Pedersen N.L., Perjakova N., Peters A., Peters U., Pharoah P.D.P., Polasek O., Porcu E., Psaty B.M., Rahman I., Rennert G., Rennert H.S., Ridker P.M., Ring S.M., Robino A., Rose L.M., Rosendaal F.R., Rossouw J., Rudan I., Rueedi R., Ruggiero D., Sala C.F., Saloustros E., Sandler D.P., Sanna S., Sawyer E.J., Sarnowski C., Schlessinger D., Schmidt M.K., Schoemaker M.J., Schraut K.E., Scott C., Shekari S., Shrikhande A., Smith A.V., Smith B.H., Smith J.A., Sorice R., Southey M.C., Spector T.D., Spinelli J.J., Stampfer M., Stockl D., van Meurs J.B.J., Strauch K., Styrkarsdottir U., Swerdlow A.J., Tanaka T., Teras L.R., Teumer A., Thorsteinsdottir U., Timpson N.J., Toniolo D., Traglia M., Troester M.A., Truong T., Tyrrell J., Uitterlinden A.G., Ulivi S., Vachon C.M., Vitart V., Volker U., Vollenweider P., Volzke H., Wang Q., Wareham N.J., Weinberg C.R., Weir D.R., Wilcox A.N., van Dijk K.W., Willemsen G., Wilson J.F., Wolffenbuttel B.H.R., Wolk A., Wood A.R., Zhao W., Zygmunt M., Chen Z., Li L., Franke L., Burgess S., Deelen P., Pers T.H., Grondahl M.L., Andersen C.Y., Pujol A., Lopez-Contreras A.J., Daniel J.A., Stefansson K., Chang-Claude J., van der Schouw Y.T., Lunetta K.L., Chasman D.I., Easton D.F., Visser J.A., Ozanne S.E., Namekawa S.H., Solc P., Murabito J.M., Ong K.K., Hoffmann E.R., Murray A., Roig I., Perry J.R.B., Ruth K.S., Day F.R., Hussain J., Martinez-Marchal A., Aiken C.E., Azad A., Thompson D.J., Knoblochova L., Abe H., Tarry-Adkins J.L., Gonzalez J.M., Fontanillas P., Claringbould A., Bakker O.B., Sulem P., Walters R.G., Terao C., Turon S., Horikoshi M., Lin K., Onland-Moret N.C., Sankar A., Hertz E.P.T., Timshel P.N., Shukla V., Borup R., Olsen K.W., Aguilera P., Ferrer-Roda M., Huang Y., Stankovic S., Timmers P.R.H.J., Ahearn T.U., Alizadeh B.Z., Naderi E., Andrulis I.L., Arnold A.M., Aronson K.J., Augustinsson A., Bandinelli S., Barbieri C.M., Beaumont R.N., Becher H., Beckmann M.W., Benonisdottir S., Bergmann S., Bochud M., Boerwinkle E., Bojesen S.E., Bolla M.K., Boomsma D.I., Bowker N., Brody J.A., Broer L., Buring J.E., Campbell A., Campbell H., Castelao J.E., Catamo E., Chanock S.J., Chenevix-Trench G., Ciullo M., Corre T., Couch F.J., Cox A., Crisponi L., Cross S.S., Cucca F., Czene K., Smith G.D., de Geus E.J.C.N., de Mutsert R., De Vivo I., Demerath E.W., Dennis J., Dunning A.M., Dwek M., Eriksson M., Esko T., Fasching P.A., Faul J.D., Ferrucci L., Franceschini N., Frayling T.M., Gago-Dominguez M., Mezzavilla M., Garcia-Closas M., Gieger C., Giles G.G., Grallert H., Gudbjartsson D.F., Gudnason V., Guenel P., Haiman C.A., Hakansson N., Hall P., Hayward C., He C., He W., Heiss G., Hoffding M.K., Hopper J.L., Hottenga J.J., Hu F., Hunter D., Ikram M.A., Jackson R.D., Joaquim M.D.R., John E.M., Joshi P.K., Karasik D., Kardia S.L.R., Kartsonaki C., Karlsson R., Kitahara C.M., Kolcic I., Kooperberg C., Kraft P., Kurian A.W., Kutalik Z., La Bianca M., LaChance G., Langenberg C., Launer L.J., Laven J.S.E., Lawlor D.A., Le Marchand L., Li J., Lindblom A., Lindstrom S., Lindstrom T., Linet M., Liu Y.M., Liu S., Luan J., Magi R., Magnusson P.K.E., Mangino M., Mannermaa A., Marco B., Marten J., Martin N.G., Mbarek H., McKnight B., Medland S.E., Meisinger C., Meitinger T., Menni C., Metspalu A., Milani L., Milne R.L., Montgomery G.W., Mook-Kanamori D.O., Mulas A., Mulligan A.M., Nalls M.A., Newman A., Noordam R., Nutile T., Nyholt D.R., Olshan A.F., Olsson H., Painter J.N., Patel A.V., Pedersen N.L., Perjakova N., Peters A., Peters U., Pharoah P.D.P., Polasek O., Porcu E., Psaty B.M., Rahman I., Rennert G., Rennert H.S., Ridker P.M., Ring S.M., Robino A., Rose L.M., Rosendaal F.R., Rossouw J., Rudan I., Rueedi R., Ruggiero D., Sala C.F., Saloustros E., Sandler D.P., Sanna S., Sawyer E.J., Sarnowski C., Schlessinger D., Schmidt M.K., Schoemaker M.J., Schraut K.E., Scott C., Shekari S., Shrikhande A., Smith A.V., Smith B.H., Smith J.A., Sorice R., Southey M.C., Spector T.D., Spinelli J.J., Stampfer M., Stockl D., van Meurs J.B.J., Strauch K., Styrkarsdottir U., Swerdlow A.J., Tanaka T., Teras L.R., Teumer A., Thorsteinsdottir U., Timpson N.J., Toniolo D., Traglia M., Troester M.A., Truong T., Tyrrell J., Uitterlinden A.G., Ulivi S., Vachon C.M., Vitart V., Volker U., Vollenweider P., Volzke H., Wang Q., Wareham N.J., Weinberg C.R., Weir D.R., Wilcox A.N., van Dijk K.W., Willemsen G., Wilson J.F., Wolffenbuttel B.H.R., Wolk A., Wood A.R., Zhao W., Zygmunt M., Chen Z., Li L., Franke L., Burgess S., Deelen P., Pers T.H., Grondahl M.L., Andersen C.Y., Pujol A., Lopez-Contreras A.J., Daniel J.A., Stefansson K., Chang-Claude J., van der Schouw Y.T., Lunetta K.L., Chasman D.I., Easton D.F., Visser J.A., Ozanne S.E., Namekawa S.H., Solc P., Murabito J.M., Ong K.K., Hoffmann E.R., Murray A., Roig I., and Perry J.R.B.
Abstract: Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry. These common alleles were associated with clinical extremes of ANM; women in the top 1% of genetic susceptibility have an equivalent risk of premature ovarian insufficiency to those carrying monogenic FMR1 premutations3. The identified loci implicate a broad range of DNA damage response (DDR) processes and include loss-of-function variants in key DDR-associated genes. Integration with experimental models demonstrates that these DDR processes act across the life-course to shape the ovarian reserve and its rate of depletion. Furthermore, we demonstrate that experimental manipulation of DDR pathways highlighted by human genetics increases fertility and extends reproductive life in mice. Causal inference analyses using the identified genetic variants indicate that extending reproductive life in women improves bone health and reduces risk of type 2 diabetes, but increases the risk of hormone-sensitive cancers. These findings provide insight into the mechanisms that govern ovarian ageing, when they act, and how they might be targeted by therapeutic approaches to extend fertility and prevent disease.Copyright © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
Published: 2021

48. Erratum: Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (Nature communications (2021) 12 1 (1078)).

Author: Coignard J., Lush M., Beesley J., O'Mara T.A., Dennis J., Tyrer J.P., Barnes D.R., McGuffog L., Leslie G., Bolla M.K., Adank M.A., Agata S., Ahearn T., Aittomaki K., Andrulis I.L., Anton-Culver H., Arndt V., Arnold N., Aronson K.J., Arun B.K., Augustinsson A., Azzollini J., Barrowdale D., Baynes C., Becher H., Bermisheva M., Bernstein L., Bialkowska K., Blomqvist C., Bojesen S.E., Bonanni B., Borg A., Brauch H., Brenner H., Burwinkel B., Buys S.S., Caldes T., Caligo M.A., Campa D., Carter B.D., Castelao J.E., Chang-Claude J., Chanock S.J., Chung W.K., Claes K.B.M., Clarke C.L., Collee J.M., Conroy D.M., Czene K., Daly M.B., Devilee P., Diez O., Ding Y.C., Domchek S.M., Dork T., Dos-Santos-Silva I., Dunning A.M., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fostira F., Friedman E., Fritschi L., Frost D., Gago-Dominguez M., Gapstur S.M., Garber J., Garcia-Barberan V., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Gayther S.A., Gehrig A., Georgoulias V., Giles G.G., Godwin A.K., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Greene M.H., Guenel P., Haeberle L., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., He W., Hogervorst F.B.L., Hollestelle A., Hopper J.L., Horcasitas D.J., Hulick P.J., Hunter D.J., Imyanitov E.N., Jager A., Jakubowska A., James P.A., Jensen U.B., John E.M., Jones M.E., Kaaks R., Kapoor P.M., Karlan B.Y., Keeman R., Khusnutdinova E., Kiiski J.I., Ko Y.-D., Kosma V.-M., Kraft P., Kurian A.W., Laitman Y., Lambrechts D., Le Marchand L., Lester J., Lesueur F., Lindstrom T., Lopez-Fernandez A., Loud J.T., Luccarini C., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mebirouk N., Meindl A., Miller A., Milne R.L., Montagna M., Nathanson K.L., Neuhausen S.L., Nevanlinna H., Nielsen F.C., O'Brien K.M., Olopade O.I., Olson J.E., Olsson H., Osorio A., Ottini L., Park-Simon T.-W., Parsons M.T., Pedersen I.S., Peshkin B., Peterlongo P., Peto J., Pharoah P.D.P., Phillips K.-A., Polley E.C., Poppe B., Presneau N., Pujana M.A., Punie K., Radice P., Rantala J., Rashid M.U., Rennert G., Rennert H.S., Robson M., Romero A., Rossing M., Saloustros E., Sandler D.P., Santella R., Scheuner M.T., Schmidt M.K., Schmidt G., Scott C., Sharma P., Soucy P., Southey M.C., Spinelli J.J., Steinsnyder Z., Stone J., Stoppa-Lyonnet D., Swerdlow A., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Teule A., Thull D.L., Tischkowitz M., Toland A.E., Torres D., Trainer A.H., Truong T., Tung N., Vachon C.M., Vega A., Vijai J., Wang Q., Wappenschmidt B., Weinberg C.R., Weitzel J.N., Wendt C., Wolk A., Yadav S., Yang X.R., Yannoukakos D., Zheng W., Ziogas A., Zorn K.K., Park S.K., Thomassen M., Offit K., Schmutzler R.K., Couch F.J., Simard J., Chenevix-Trench G., Easton D.F., Andrieu N., Antoniou A.C., Coignard J., Lush M., Beesley J., O'Mara T.A., Dennis J., Tyrer J.P., Barnes D.R., McGuffog L., Leslie G., Bolla M.K., Adank M.A., Agata S., Ahearn T., Aittomaki K., Andrulis I.L., Anton-Culver H., Arndt V., Arnold N., Aronson K.J., Arun B.K., Augustinsson A., Azzollini J., Barrowdale D., Baynes C., Becher H., Bermisheva M., Bernstein L., Bialkowska K., Blomqvist C., Bojesen S.E., Bonanni B., Borg A., Brauch H., Brenner H., Burwinkel B., Buys S.S., Caldes T., Caligo M.A., Campa D., Carter B.D., Castelao J.E., Chang-Claude J., Chanock S.J., Chung W.K., Claes K.B.M., Clarke C.L., Collee J.M., Conroy D.M., Czene K., Daly M.B., Devilee P., Diez O., Ding Y.C., Domchek S.M., Dork T., Dos-Santos-Silva I., Dunning A.M., Dwek M., Eccles D.M., Eliassen A.H., Engel C., Eriksson M., Evans D.G., Fasching P.A., Flyger H., Fostira F., Friedman E., Fritschi L., Frost D., Gago-Dominguez M., Gapstur S.M., Garber J., Garcia-Barberan V., Garcia-Closas M., Garcia-Saenz J.A., Gaudet M.M., Gayther S.A., Gehrig A., Georgoulias V., Giles G.G., Godwin A.K., Goldberg M.S., Goldgar D.E., Gonzalez-Neira A., Greene M.H., Guenel P., Haeberle L., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., He W., Hogervorst F.B.L., Hollestelle A., Hopper J.L., Horcasitas D.J., Hulick P.J., Hunter D.J., Imyanitov E.N., Jager A., Jakubowska A., James P.A., Jensen U.B., John E.M., Jones M.E., Kaaks R., Kapoor P.M., Karlan B.Y., Keeman R., Khusnutdinova E., Kiiski J.I., Ko Y.-D., Kosma V.-M., Kraft P., Kurian A.W., Laitman Y., Lambrechts D., Le Marchand L., Lester J., Lesueur F., Lindstrom T., Lopez-Fernandez A., Loud J.T., Luccarini C., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mebirouk N., Meindl A., Miller A., Milne R.L., Montagna M., Nathanson K.L., Neuhausen S.L., Nevanlinna H., Nielsen F.C., O'Brien K.M., Olopade O.I., Olson J.E., Olsson H., Osorio A., Ottini L., Park-Simon T.-W., Parsons M.T., Pedersen I.S., Peshkin B., Peterlongo P., Peto J., Pharoah P.D.P., Phillips K.-A., Polley E.C., Poppe B., Presneau N., Pujana M.A., Punie K., Radice P., Rantala J., Rashid M.U., Rennert G., Rennert H.S., Robson M., Romero A., Rossing M., Saloustros E., Sandler D.P., Santella R., Scheuner M.T., Schmidt M.K., Schmidt G., Scott C., Sharma P., Soucy P., Southey M.C., Spinelli J.J., Steinsnyder Z., Stone J., Stoppa-Lyonnet D., Swerdlow A., Tamimi R.M., Tapper W.J., Taylor J.A., Terry M.B., Teule A., Thull D.L., Tischkowitz M., Toland A.E., Torres D., Trainer A.H., Truong T., Tung N., Vachon C.M., Vega A., Vijai J., Wang Q., Wappenschmidt B., Weinberg C.R., Weitzel J.N., Wendt C., Wolk A., Yadav S., Yang X.R., Yannoukakos D., Zheng W., Ziogas A., Zorn K.K., Park S.K., Thomassen M., Offit K., Schmutzler R.K., Couch F.J., Simard J., Chenevix-Trench G., Easton D.F., Andrieu N., and Antoniou A.C.
Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4.
Published: 2021

49. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.

Author: Johnson N., Maguire S., Morra A., Kapoor P.M., Tomczyk K., Jones M.E., Schoemaker M.J., Gilham C., Bolla M.K., Wang Q., Dennis J., Ahearn T.U., Andrulis I.L., Anton-Culver H., Antonenkova N.N., Arndt V., Aronson K.J., Augustinsson A., Baynes C., Freeman L.E.B., Beckmann M.W., Benitez J., Bermisheva M., Blomqvist C., Boeckx B., Bogdanova N.V., Bojesen S.E., Brauch H., Brenner H., Burwinkel B., Campa D., Canzian F., Castelao J.E., Chanock S.J., Chenevix-Trench G., Clarke C.L., Borresen-Dale A.-L., Alnaes G.I.G., Sahlberg K.K., Ottestad L., Karesen R., Schlichting E., Holmen M.M., Sauer T., Haakensen V., Engebraten O., Naume B., Fossa A., Kiserud C.E., Reinertsen K.V., Helland A., Riis M., Geisler J., Conroy D.M., Couch F.J., Cox A., Cross S.S., Czene K., Dork T., Eliassen A.H., Engel C., Evans D.G., Fasching P.A., Figueroa J., Floris G., Flyger H., Gago-Dominguez M., Gapstur S.M., Garcia-Closas M., Gaudet M.M., Giles G.G., Goldberg M.S., Gonzalez-Neira A., Bowtell D.D.L., Webb P.M., Guenel P., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., Hooning M.J., Hopper J.L., Howell A., Hunter D.J., Clarke C., Scott R., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Graham D., Sachchithananthan M., Amor D., Andrews L., Antill Y., Balleine R., Beesley J., Bennett I., Bogwitz M., Botes L., Brennan M., Brown M., Buckley M., Burke J., Butow P., Caldon L., Campbell I., Chauhan D., Chauhan M., Christian A., Cohen P., Colley A., Crook A., Cui J., Cummings M., Dawson S.-J., DeFazio A., Delatycki M., Dickson R., Dixon J., Edkins T., Edwards S., Farshid G., Fellows A., Fenton G., Field M., Flanagan J., Fong P., Forrest L., Fox S., French J., Friedlander M., Gaff C., Gattas M., George P., Greening S., Harris M., Hart S., Hayward N., Hopper J., Hoskins C., Hunt C., James P., Jenkins M., Kidd A., Kirk J., Koehler J., Kollias J., Lakhani S., Lawrence M., Lindeman G., Lipton L., Lobb L., Mann G., Marsh D., McLachlan S.A., Meiser B., Milne R.L., Nightingale S., O'Connell S., O'Sullivan S., Ortega D.G., Pachter N., Patterson B., Pearn A., Phillips K., Pieper E., Rickard E., Robinson B., Saleh M., Salisbury E., Saunders C., Saunus J., Sexton A., Shelling A., Simpson P., Southey M.C., Spurdle A., Taylor J., Taylor R., Thorne H., Trainer A., Tucker K., Visvader J., Walker L., Williams R., Winship I., Young M.A., Jager A., Jakubowska A., John E.M., Keeman R., Khusnutdinova E., Kitahara C.M., Kosma V.-M., Koutros S., Kraft P., Kristensen V.N., Kurian A.W., Lambrechts D., Le Marchand L., Linet M., Lubinski J., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mavroudis D., Mayes R., Meindl A., Neuhausen S.L., Nevanlinna H., Newman W.G., Nielsen S.F., Nordestgaard B.G., Obi N., Olshan A.F., Olson J.E., Olsson H., Orban E., Park-Simon T.-W., Peterlongo P., Plaseska-Karanfilska D., Pylkas K., Rennert G., Rennert H.S., Ruddy K.J., Saloustros E., Sandler D.P., Sawyer E.J., Schmutzler R.K., Scott C., Shu X.-O., Simard J., Smichkoska S., Sohn C., Spinelli J.J., Stone J., Tamimi R.M., Taylor J.A., Tollenaar R.A.E.M., Tomlinson I., Troester M.A., Truong T., Vachon C.M., van Veen E.M., Wang S.S., Weinberg C.R., Wendt C., Wildiers H., Winqvist R., Wolk A., Zheng W., Ziogas A., Dunning A.M., Pharoah P.D.P., Easton D.F., Howie A.F., Peto J., dos-Santos-Silva I., Swerdlow A.J., Chang-Claude J., Schmidt M.K., Orr N., Fletcher O., Johnson N., Maguire S., Morra A., Kapoor P.M., Tomczyk K., Jones M.E., Schoemaker M.J., Gilham C., Bolla M.K., Wang Q., Dennis J., Ahearn T.U., Andrulis I.L., Anton-Culver H., Antonenkova N.N., Arndt V., Aronson K.J., Augustinsson A., Baynes C., Freeman L.E.B., Beckmann M.W., Benitez J., Bermisheva M., Blomqvist C., Boeckx B., Bogdanova N.V., Bojesen S.E., Brauch H., Brenner H., Burwinkel B., Campa D., Canzian F., Castelao J.E., Chanock S.J., Chenevix-Trench G., Clarke C.L., Borresen-Dale A.-L., Alnaes G.I.G., Sahlberg K.K., Ottestad L., Karesen R., Schlichting E., Holmen M.M., Sauer T., Haakensen V., Engebraten O., Naume B., Fossa A., Kiserud C.E., Reinertsen K.V., Helland A., Riis M., Geisler J., Conroy D.M., Couch F.J., Cox A., Cross S.S., Czene K., Dork T., Eliassen A.H., Engel C., Evans D.G., Fasching P.A., Figueroa J., Floris G., Flyger H., Gago-Dominguez M., Gapstur S.M., Garcia-Closas M., Gaudet M.M., Giles G.G., Goldberg M.S., Gonzalez-Neira A., Bowtell D.D.L., Webb P.M., Guenel P., Hahnen E., Haiman C.A., Hakansson N., Hall P., Hamann U., Harrington P.A., Hart S.N., Hooning M.J., Hopper J.L., Howell A., Hunter D.J., Clarke C., Scott R., Baxter R., Yip D., Carpenter J., Davis A., Pathmanathan N., Graham D., Sachchithananthan M., Amor D., Andrews L., Antill Y., Balleine R., Beesley J., Bennett I., Bogwitz M., Botes L., Brennan M., Brown M., Buckley M., Burke J., Butow P., Caldon L., Campbell I., Chauhan D., Chauhan M., Christian A., Cohen P., Colley A., Crook A., Cui J., Cummings M., Dawson S.-J., DeFazio A., Delatycki M., Dickson R., Dixon J., Edkins T., Edwards S., Farshid G., Fellows A., Fenton G., Field M., Flanagan J., Fong P., Forrest L., Fox S., French J., Friedlander M., Gaff C., Gattas M., George P., Greening S., Harris M., Hart S., Hayward N., Hopper J., Hoskins C., Hunt C., James P., Jenkins M., Kidd A., Kirk J., Koehler J., Kollias J., Lakhani S., Lawrence M., Lindeman G., Lipton L., Lobb L., Mann G., Marsh D., McLachlan S.A., Meiser B., Milne R.L., Nightingale S., O'Connell S., O'Sullivan S., Ortega D.G., Pachter N., Patterson B., Pearn A., Phillips K., Pieper E., Rickard E., Robinson B., Saleh M., Salisbury E., Saunders C., Saunus J., Sexton A., Shelling A., Simpson P., Southey M.C., Spurdle A., Taylor J., Taylor R., Thorne H., Trainer A., Tucker K., Visvader J., Walker L., Williams R., Winship I., Young M.A., Jager A., Jakubowska A., John E.M., Keeman R., Khusnutdinova E., Kitahara C.M., Kosma V.-M., Koutros S., Kraft P., Kristensen V.N., Kurian A.W., Lambrechts D., Le Marchand L., Linet M., Lubinski J., Mannermaa A., Manoukian S., Margolin S., Martens J.W.M., Mavroudis D., Mayes R., Meindl A., Neuhausen S.L., Nevanlinna H., Newman W.G., Nielsen S.F., Nordestgaard B.G., Obi N., Olshan A.F., Olson J.E., Olsson H., Orban E., Park-Simon T.-W., Peterlongo P., Plaseska-Karanfilska D., Pylkas K., Rennert G., Rennert H.S., Ruddy K.J., Saloustros E., Sandler D.P., Sawyer E.J., Schmutzler R.K., Scott C., Shu X.-O., Simard J., Smichkoska S., Sohn C., Spinelli J.J., Stone J., Tamimi R.M., Taylor J.A., Tollenaar R.A.E.M., Tomlinson I., Troester M.A., Truong T., Vachon C.M., van Veen E.M., Wang S.S., Weinberg C.R., Wendt C., Wildiers H., Winqvist R., Wolk A., Zheng W., Ziogas A., Dunning A.M., Pharoah P.D.P., Easton D.F., Howie A.F., Peto J., dos-Santos-Silva I., Swerdlow A.J., Chang-Claude J., Schmidt M.K., Orr N., and Fletcher O.
Abstract: Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Method(s): We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Result(s): For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 x 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 x 10-8). Conclusion(s): The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.Copyright © 2021, The Author(s).
Published: 2021

50. Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk.

Author: Kapoor P.M., Mavaddat N., Choudhury P.P., Wilcox A.N., Lindstrom S., Behrens S., Michailidou K., Dennis J., Bolla M.K., Wang Q., Jung A., Abu-Ful Z., Ahearn T., Andrulis I.L., Anton-Culver H., Arndt V., Aronson K.J., Auer P.L., Freeman L.E.B., Becher H., Beckmann M.W., Beeghly-Fadiel A., Benitez J., Bernstein L., Bojesen S.E., Brauch H., Brenner H., Bruning T., Cai Q., Campa D., Canzian F., Carracedo A., Carter B.D., Castelao J.E., Chanock S.J., Chatterjee N., Chenevix-Trench G., Clarke C.L., Couch F.J., Cox A., Cross S.S., Czene K., Dai J.Y., Earp H.S., Ekici A.B., Eliassen A.H., Eriksson M., Evans D.G., Fasching P.A., Figueroa J., Fritschi L., Gabrielson M., Gago-Dominguez M., Gao C., Gapstur S.M., Gaudet M.M., Giles G.G., Gonzalez-Neira A., Guenel P., Haeberle L., Haiman C.A., Hakansson N., Hall P., Hamann U., Hatse S., Heyworth J., Holleczek B., Hoover R.N., Hopper J.L., Howell A., Hunter D.J., John E.M., Jones M.E., Kaaks R., Keeman R., Kitahara C.M., Ko Y.-D., Koutros S., Kurian A.W., Lambrechts D., Le Marchand L., Lee E., Lejbkowicz F., Linet M., Lissowska J., Llaneza A., Macinnis R.J., Martinez M.E., Maurer T., Mclean C., Neuhausen S.L., Newman W.G., Norman A., O'brien K.M., Olshan A.F., Olson J.E., Olsson H., Orr N., Perou C.M., Pita G., Polley E.C., Prentice R.L., Rennert G., Rennert H.S., Ruddy K.J., Sandler D.P., Saunders C., Schoemaker M.J., Schottker B., Schumacher F., Scott C., Scott R.J., Shu X.-O., Smeets A., Southey M.C., Spinelli J.J., Stone J., Swerdlow A.J., Tamimi R.M., Taylor J.A., Troester M.A., Vachon C.M., Van Veen E.M., Wang X., Weinberg C.R., Weltens C., Willett W., Winham S.J., Wolk A., Yang X.R., Zheng W., Ziogas A., Dunning A.M., Pharoah P.D.P., Schmidt M.K., Kraft P., Easton D.F., Milne R.L., Garcia-Closas M., Chang-Claude J., Kapoor P.M., Mavaddat N., Choudhury P.P., Wilcox A.N., Lindstrom S., Behrens S., Michailidou K., Dennis J., Bolla M.K., Wang Q., Jung A., Abu-Ful Z., Ahearn T., Andrulis I.L., Anton-Culver H., Arndt V., Aronson K.J., Auer P.L., Freeman L.E.B., Becher H., Beckmann M.W., Beeghly-Fadiel A., Benitez J., Bernstein L., Bojesen S.E., Brauch H., Brenner H., Bruning T., Cai Q., Campa D., Canzian F., Carracedo A., Carter B.D., Castelao J.E., Chanock S.J., Chatterjee N., Chenevix-Trench G., Clarke C.L., Couch F.J., Cox A., Cross S.S., Czene K., Dai J.Y., Earp H.S., Ekici A.B., Eliassen A.H., Eriksson M., Evans D.G., Fasching P.A., Figueroa J., Fritschi L., Gabrielson M., Gago-Dominguez M., Gao C., Gapstur S.M., Gaudet M.M., Giles G.G., Gonzalez-Neira A., Guenel P., Haeberle L., Haiman C.A., Hakansson N., Hall P., Hamann U., Hatse S., Heyworth J., Holleczek B., Hoover R.N., Hopper J.L., Howell A., Hunter D.J., John E.M., Jones M.E., Kaaks R., Keeman R., Kitahara C.M., Ko Y.-D., Koutros S., Kurian A.W., Lambrechts D., Le Marchand L., Lee E., Lejbkowicz F., Linet M., Lissowska J., Llaneza A., Macinnis R.J., Martinez M.E., Maurer T., Mclean C., Neuhausen S.L., Newman W.G., Norman A., O'brien K.M., Olshan A.F., Olson J.E., Olsson H., Orr N., Perou C.M., Pita G., Polley E.C., Prentice R.L., Rennert G., Rennert H.S., Ruddy K.J., Sandler D.P., Saunders C., Schoemaker M.J., Schottker B., Schumacher F., Scott C., Scott R.J., Shu X.-O., Smeets A., Southey M.C., Spinelli J.J., Stone J., Swerdlow A.J., Tamimi R.M., Taylor J.A., Troester M.A., Vachon C.M., Van Veen E.M., Wang X., Weinberg C.R., Weltens C., Willett W., Winham S.J., Wolk A., Yang X.R., Zheng W., Ziogas A., Dunning A.M., Pharoah P.D.P., Schmidt M.K., Kraft P., Easton D.F., Milne R.L., Garcia-Closas M., and Chang-Claude J.
Abstract: We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. Copyright © 2020 The Author(s).
Published: 2021

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