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Maddi duran varlıklar, işletme bünyesinde yer alan, fiziki yapıya sahip ve bir hesap döneminden fazla süreyle işletme faaliyetlerinde kullanılan varlıkları ifade etmektedir. Maddi duran varlıkların kullanımı sonucunda, bu varlıkların faydalarının tükenen kısmının dönemsellik ilkesi gereği hasılatla eşleştirilmesi gerekmektedir. Ancak bu hesaplamanın kesin bir sonuç verecek şekilde yapılması mümkün değildir. Muhasebe teorisi açısından bu sorun amortisman kavramı vasıtasıyla çözülmeye çalışılmıştır. Maddi duran varlığın maliyetinin tükenen ve döneme isabet eden kısmı olarak ifade edilen amortismanın hesaplanabilmesi için birtakım varsayımlardan yola çıkılarak oluşturulan yöntemler ise amortisman yöntemleri olarak adlandırılmaktadır. Muhasebe teorisi, amortisman kavramına ve amortisman yöntemlerine olabildiğince geniş çerçevede yaklaşmakla beraber teori ışığında oluşturulan muhasebe standartları da teoriyle uyumlu bir bakış açısına sahiptir. Ancak Türkiye'de amortisman konusunda temel yaklaşım olarak muhasebe standartları yerine Türk Vergi sistemi (TVS) benimsendiği için mevzuatta teori ve standartlarla çelişen birçok düzenleme bulunmaktadır. Bu yüzden işletme ilgililerine yönelik faydalı finansal bilginin üretimi ve gerçeğe uygun şekilde sunumu mümkün olmamaktadır. Çalışma ile muhasebe literatüründe yer alan amortisman kavram ve yöntemlerinin muhasebe standartları ve TVS açısından karşılaştırılarak uygulama ve teori arasındaki farkların ortaya konulması amaçlanmış olup TVS’de yer alan düzenlemelerin gerçeğe uygun sunumdan ziyade teşvik veya kısıtlama niteliğinde olduğunu ve söz konusu düzenlemelerde muhasebe ilkelerine uygunluğun gözetilmediğini ifade etmek mümkündür.

Bu makalede 1848-1849 Devrimleri dönemi temel alınarak Habsburg Slavlarının federalizm ilkesi temelinde geliştirdikleri Austroslavizm düşüncesinin politik programı anlatılacaktır. Austroslavizm düşüncesi Çek düşünür ve politikacılar tarafından formüle edilmiş ve Orta Avrupa Slavlarının federal bir şekilde düzenlenecek Habbsurg Monarşisi içinde kurulacak ayrı bir federe birim altında toplanarak Alman ve Rus yayılmacılığına karşı kendilerini savunmalarını amaçlamıştır. Bu bakımdan çalışmada sırasıyla önce Alman düşünürlerin perspektifinde Orta Avrupa kavramının ne anlama geldiği açıklanırken daha sonra Habsurg Monarşisi Slavlarının geliştirdiği Austroslavizm düşüncesi ve politik programı incelenecektir. Bu bağlamda Austroslavizm programının geliştirilmesinde önemli bir rol oynayan Çek düşünür František Palačky’nin görüşlerine yer verilecektir. Almanların ve Habsburg Slavlarının Orta Avrupa kavramını nasıl düşündükleri konusundaki farklılıkları tarihsel bağlam içerisinde dönemin düşünür ve politikacıların ortaya koyduğu programlar çerçevesinde gösterilecektir. Çalışma XIX. yüzyılda Habbsurg Slavlarının oluşturduğu Austroslavizm programının günümüzde Avrupa Birliği içinde hâlâ Slav ulusların izlediği politikalar bakımından da bir temel oluşturduğu şeklinde bir iddia da ortaya atmaktadır.

The number of radiant heating-cooling systems in building applications is increasing it is because of low energy consumption, low operating temperature and high values they provide in terms of working compatibility with renewable energy sources. In this study, ground source heat pump integrated radiant panels installed on the wall and suspended ceiling of the office room in Yıldız Technical University Science and Technology Application and Research Centre were experimentally examined in terms of thermal comfort according to the relevant standards. Vertical air temperature differences and mean radiant temperatures were investigated. The mean air temperature differences at 0.1 m and 1.7 m were found to be 3,9 oC 2.9 oC 3.5 oC, 3.1 oC and 3.4 oC on average for the five different stands, respectively. PMV and PPD values were found to be 0.78 and 18.9% for February 12 (Case 1), 0.36 and 8.4% for February 13 (Case 2), respectively. In the experiment carried out under the conditions of Case 2, while the comfort conditions were provided in almost all of the day, the desired comfort conditions could not be achieved in Case 1 after 11 am. © 2022. All Rights Reserved. Yildiz Teknik Üniversitesi: FBA-2019-3703 This study was supported by Yıldız Technical University under BAP program with GRANT No. FBA-2019-3703. We would like to thank to the Yıldız Technical University for their financial support during this work.

Sustainable production and consumption in the food supply chain are critical for the United Nations’ sustainable development goals (SDGs). Therefore, it is significant to identify the factors that shape individuals’ food consumption behaviour. Türkiye prioritises sustainable food consumption and the prevention of food loss and waste as a national focus. Accordingly, this study aims to identify the drivers of individuals’ food consumption habits in Türkiye through a survey with the participants being households in Izmir, the third most populous city in Türkiye. More specifically, the study has two main objectives: (i) to identify the factors influencing households’ food consumption preferences and (ii) to demonstrate how the factors concerning sustainable food consumption interact through a survey conducted in Izmir. Based on the state-of-art literature, an online survey was completed by 515 respondents in Izmir. Through an analysis of the survey responses, this study provides a descriptive analysis of socio-demographic variables and a correlation analysis between socio-demographics and sustainable food consumption behaviours, including food shopping behaviour, food purchasing and consumption behaviour, dietary habits, and food waste behaviour. The results demonstrate that socio-demographic factors such as age, gender, education level, income level, and the number of residents in the household are significant for sustainable food consumption behaviour. The survey results also demonstrate that the respondents do not consider carbon footprint generation from food production and transportation in their decisions or behaviours. The study’s main limitation is that the survey is implemented in a single city, Izmir. Future research may extend the scope to other cities in Türkiye, allowing a comparative analysis.

Aim: The aim of this study was to evaluate the efficacy of Lapatinib, trastuzumab emtansine (T-DM1) treatment after pertuzumab in patients with HER2-positive metastatic breast cancer. Materials and Methods: The study included HER2-positive breast cancer patients who were followed up and treated in Adana City Training and Research Hospital. Totally 1840 patients with a diagnosis of breast cancer in the hospital management system were evaluated, 670 patients who were determined to be metastatic were evaluated for eligibility. Thirty-one patients who received pertuzumab before T-DM1 treatment, while 34 patients who received T-DM1 before pertuzumab were included. Results: Of the 65 female patients included in the study, 59 had ductal adenocarcinoma (90.8%) and 6 had lobular adenocarcinoma (9.2%). Seventeen patients (26.2%) had bone metastases, 20 patients (30.7%) had visceral metastases, and 28 patients (43.1%) had bone and visceral metastases together. Overall survival (OS) was 23.8±3 months in those who did not receive pertuzumab before T-DM1 in the metastatic setting, while it was similar in those who received pertuzumab with 22.4±2.9 months (p=0.969). Progression-free survival (PFS) was 9.1±1.3 months in those who did not receive pertuzumab before T-DM1 in the metastatic setting, while it was significantly lower in patients who received pertuzumab with 4.9±0.8 months (p=0.005). The comparison of initiation of T-DM1 after pertuzumab as second-line therapy in the metastatic setting and its use in later therapeutic lines revealed no difference in PFS and OS (p=0.628 and p=0.706, respectively). Conclusion: Pertuzumab should be preferred primarily because it is more effective in metastatic HER2-positive breast cancer. Despite the significant decrease in PFS of patients using T-DM1 after pertuzumab, there was no decrease in OS; therefore the earlier T-DM1 therapy is initiated following pertuzumab, the more effective it is.

Background:This study aims to compare the effectiveness of surgical and conservative medical treatments for bezoar ileus in patients with a history of abdominal surgery. Methods:A total of 80 patients diagnosed with bezoar ileus and with a history of abdominal surgery were included in this study. Patients were divided into two groups based on treatment: conservative medical (n=26) management and surgical (n=54). The primary outcome measure was the resolution of the bezoar ileus without complications. Secondary outcome measures include the length of hospital stay, mortality, and readmission after discharge. Data were collected from electronic medical records and analysed using appropriate statistical methods. Results:Eighty patients were included in the study, with 26 and 54 patients in treatment groups. The uncomplicated resolution rate was in the surgical group (74,42%), and all complications were related to the postoperative follow-up period. No complication developed during the treatment in 26 patients who received medical treatment. The surgical group also had a significantly shorter hospital stay (mean four days) compared to the medical group (mean seven days) (p < 0.01). Mortality and readmission after discharge rates were similar between the two groups. Conclusions:Results were similar between surgical treatment and conservative medical treatment in the resolution of bezoar ileus. Surgical treatment was more effective than conservative medical management in reducing hospital stays in patients with prior abdominal surgery. Between the group treated without surgery and the group treated with surgery, respectively, no statistically significant difference was found in terms of mean age, female-male distribution, concomitant disease (excluding cancer history), localization (excluding stomach), bezoar width and length, mortality, incision type (except McBurney), and readmission after discharge (p>0.05). Nonetheless, further prospective studies with larger sample sizes and extended follow-up periods must confirm these findings.

For automatic guided vehicles (AGVs), maximizing the operating time with maximum energy efficiency is the most important factor that increases work efficiency. In this study, the fuel-cell-powered AGV (FCAGV) system was modeled and optimized control and design were carried out to obtain high tracking performance with minimum power consumption. Firstly, a full mathematical model of FCAGV, which involves the AGV, the fuel cell, DC/DC converters and motors, was obtained. Then, particle swarm optimization (PSO)-based intelligent PID and I controllers were developed for maximizing the route-tracking performance of AGV and voltage-tracking performance of the DC/DC converter with reduced power consumption. PSO was used to determine the optimal parameters of controllers and the values of DC/DC converters’ components. The performance of the full AGV system was analyzed for different paths. The results show that the sufficient path-tracking and voltage-tracking performance was obtained for AGV and DC/DC converters, respectively. The average tracking errors according to global coordinate system are 0.0061 m at the x axis, 0.0572 m at the y axis and 0.0228 rad at rotational axis. The obtained average voltage-tracking errors for each DC/DC converters were approximately 0.8033 V. These results indicate that the developed controllers with optimal coefficients work successfully with small voltage and path-tracking errors. During this motion, the average consumed power from the fuel cell was observed as 58.2675 W. These results show that the designed optimized intelligent controllers have sufficient performance with high energy efficiency and maximum route tracking.

The ease of functionalization of metal-organic frameworks (MOFs) can unlock unprecedented opportunities for gas adsorption and separation applications as the functional groups can impart favorable/unfavorable regions/interactions for the desired/undesired adsorbates. In this study, the effects of the presence of multiple functional groups in MOFs on their CF4/CH4, CH4/H-2, CH4/N-2, and N-2/H-2 separation performances were computationally investigated combining grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations. The most promising adsorbents showing the best combinations of selectivity, working capacity, and regenerability were identified for each gas separation. 15, 13, and 16 out of the top 20 MOFs identified for the CH4/H-2, CH4/N-2, and N-2/H-2 adsorption-based separation, respectively, were found to have -OCH3 groups as one of the functional groups. The biggest improvements in CF4/CH4, CH4/H-2, CH4/N-2, and N-2/H-2 selectivities were found to be induced by the presence of -OCH3-OCH3 groups in MOFs. For CH4/H-2 separation, MOFs with two and three functionalized linkers were the best adsorbent candidates while for N-2/H-2 separation, all the top 20 materials involve two functional groups. Membrane performances of the MOFs were also studied for CH4/H-2 and CH4/N-2 separation and the results showed that MOFs having -F-NH2 and -F-OCH3 functional groups present the highest separation performances considering both the membrane selectivity and permeability., European Research Council (ERC); European Union (EU); Horizon 2020; Research and innovation programme; ERC-2017-Starting Grant; COSMOS; Scientific and Technological Research Council (TÜBİTAK); ULAKBİM; High Performance and Grid Computing Center (TRUBA resources); National Center for High Performance Computing of Turkey (UHeM)

Objective: The Covid-19 pandemic has affected the whole world and health systems worldwide have had to revise their working methods. Although the literature includes recommendations regarding the timing of Percutaneous endoscopic gastrostomy (PEG) in Covid-19 patients, there are no significant clinical studies as yet. We aim to contribute to the literature by sharing our data on this subject.Materials and Methods: Patients who underwent PEG between March 2020-March 2021 were retrospectively evaluated and divided into two groups: patients noninfected with COVID-19 (Group 1) and COVID-19 infected patients (Group 2). Patient age, gender, medical indications, comorbid diseases, blood tests and post–intervention complications were recorded, as was whether or not the patient was in the ICU at the time of the procedure. PEG was carried out routinely in PCR-negative patients.Results: During the pandemic, PEG was placed in 67 patients who had appropriate indications. These patients predominantly consisted of those with SVH, Alzheimer's, or traumatic brain injury. Thirty-three (49.3%) patients were female with a mean age of 69.4 ± 17.6. 48 patients underwent PEG while in the intensive care unit; 11 of these patients positive for covid-19, and one had active covid-19 infection. The results of appropriately timed PEG procedures in intensive care unit patients diagnosed with Covid-19 were compared with those of other hospitalized patients and blood albumin levels, CRP, hemogram results and 30-day mortality results were found to be similar.Conclusion: The timing of the intervention for virus-infected patients is crucial. Although the most appropriate timing is the 30th day after the infection process, PEG may be performed on the 10th day in eligible patients., Amaç: COVID-19 pandemisi tüm dünyayı ve sağlık sistemlerini olumsuz şekilde etkisi altına almıştır. Literatürde COVID-19 hastalarında Perkütan endoskopik gastrostomi (PEG) zamanlaması ile ilgili öneriler yer alsa da henüz önemli bir klinik çalışma bulunmamaktadır. Bu konudaki verilerimizi paylaşarak literatüre katkı sağlamayı amaçlıyoruz.Gereç ve Yöntem: Mart 2020-Mart 2021 tarihleri arasında PEG takılan hastalar geriye dönük olarak değerlendirildi. Hastalar yaş, cinsiyet, tıbbi endikasyonlar, eşlik eden hastalıkları, kan testleri ve müdahale sonrası komplikasyonlar ile işlem sırasında hastanın yoğun bakım ünitesinde olup olmadığı kaydedildi. PCR negatif hastalarda rutin olarak PEG yapıldı. PEG uygulanan hastalar ayaktan ve yoğun bakım ünitesinde yatan hastalar olarak karşılaştırıldı. Daha sonra yoğun bakım ünitesinde yatarken PEG uygulanan hastalar, COVID-19enfeksiyonu varlığına göre iki gruba ayrıldı. ( grup-1 ve grup-2)Bulgular: Pandemi sırasında uygun endikasyonları olan 66 hastaya PEG yerleştirildi. Bu hastalar ağırlıklı olarak SVH, Alzheimer veya travmatik beyin hasarı olanlardan oluşuyordu. Çalışmada otuziki (%48.5) hasta kadındı ve yaş ortalaması 69.4±17.6 idi. Ayrıca, kırkyedi hastaya yoğun bakımdayken PEG uygulandı; bu hastalardan 11'i COVID-19 enfekte hasta grubuydu (grup-2). Grup-1 ve grup-2 arasında kan albümin düzeyleri, CRP, hemogram sonuçları ve 30 günlük mortalite sonuçları açısından istatistiksel fark yoktu (P>0.05)Sonuç: Minimal invaziv bir işlem olan peg enteral beslenme amacıyla yaygın olarak kullanılmaktadır. COVID- 19 enfekte hastalara işlemin zamanlaması önemlidir. En uygun zamanlama enfeksiyon sürecinden sonraki 30. gün olmakla birlikte uygun hastalarda 10. Gün peg uygulanabilceğini düşünmekteyiz.

The output voltage of microbial fuel cells (MFCs) needs to be controlled effectively to improve the operating efficiency of MFC system against the load variations, disturbances, and uncertainties. The output voltage control is purposed to provide the MFC with an appropriate amount of fuel required to maintain the stability of output voltage. In the applications, the MFC output voltage can be requested to track the variable reference voltage or to track the constant output voltage under changing conditions such as load change. For this purpose, two adaptive fuzzy PID (FPID) controllers powered by optimization algorithms were designed in this study to keep the output voltage value of the MFC at the desired values. This study extends the previous works by using optimization algorithms, such as particle swarm optimization (PSO) and gray wolf optimization (GWO) algorithms, to adjust fuzzy logic parameters, which are used for tuning Proportional-Integral-Derivative (PID) controllers. The optimization-based adaptive FPID controllers play an active role in efficient, fast, and robust tracking of the reference voltage value with its adaptive structure. The designed adaptive control algorithms were tested under different cases, which involve the variation of the reference voltage and load conditions. The results show that both of these controllers can effectively control the output voltage of a MFC by regulating the flow rate of the fuel. In addition, the performances of the designed controller strategies according to the results obtained vary according to the reference signal. While PSO-based FPID gives more successful results for positive step changes, GWO-based FPID gives more successful results for negative step changes. These two control strategies show more efficient, robust, successful, and faster performances compared to the traditional PID controller.

This study seeks to better understand the relationships between environmental citizenship, energy citizenship, and related phenomena and the theoretical development and operationalization processes of environmental citizenship and energy citizenship in the path towards the energy transition and climate change mitigation through a bibliometric analysis. Doing so first provides an overview of how these concepts are defined in the literature establishes the frameworks for environmental citizenship and energy citizenship, including the characteristics, drivers, and pathways to their operationalization. The subsequent bibliometric analysis is conducted via the VOSviewer software, with more than 1,300 titles from the Web of Science database published between 1992 and 2021. The search keywords are “environmental citizenship” and “energy citizenship”. The results from the analysis highlight the terms sustainability and behaviour as the overarching concepts and common points of discussion regarding environmental citizenship and energy citizenship. Moreover, although environmental citizenship preserves its central position in the scholarly debate, there is a shift towards the phenomenon of energy citizenship and a set of emerging themes including “justice”, “energy democracy”, and “sustainable development”.

Bezoars are foreign bodies developed due to the swallowing of indigestible substances in the stomach that accumulate in the lumen of the gastrointestinal tract. This study aimed to compare the location, size, and diameter of bezoars between patients with and without a history of previous gastrointestinal surgery and between operated and non-operated patients retrospectively.A total of 188 patients who presented to our gastroenterology clinic and in whom bezoar was suspected on clinical examination and the diagnosis confirmed through abdominal CT scans were included in the study. The patients were divided into two groups; patients with a history of previous gastrointestinal surgery were assigned to Group 1 (n = 70), and those who had no history of previous surgery (n = 118) to Group 2.The mean age was found as 56.16 ± 15.75 years in Group 1 and 57.71 ± 15.95 years in Group 2. The mean bezoar width was significantly higher in Group 1 (p = 0.049). The mean bezoar length was significantly higher in Group 1 (p = 0.004). Considering localization of bezoars, the rate of patients who underwent enterotomy (80%) was statistically significantly higher than the patients who underwent gastrotomy (23.50%), gastrotomy + milking (28.60%) and milking (44.70%) in the operations performed in the jejunum.Bezoars are a rare cause of intestinal obstruction. The median width and length of the bezoars were significantly higher in patients with a history of previous gastric surgery. There was no significant difference in other parameters. The most common localization was jejunum.

With the COVID-19 pandemic, supply chains are today confronted with more uncertainties than ever before. In the face of unanticipated disruptions, being resilient and sustainable has been rewarding for supply chains in terms of competitive advantage. However, literature is still far from possessing an encompassing sustainable supply chain framework (SSCF). As a contribution to the extant literature, the present study expounds a prominent concept termed negative entropy and explores its role in the SSCF. To accomplish this goal, the effect of negative entropy on supply chain sustainability is tested. Following the open systems theory and drawing from the collaboration and information management aspects of the negative entropy, co-creation, open innovation and network governance concepts which are considered to be relevant in this context are selected to be the antecedents of negative entropy. The empirical research is conducted on prominent logistics service providers and firms from various sectors with approved research and development departments in Turkey. The obtained data were subjected to covariance-based structural equation modeling analysis via Lisrel program. According to results, negative entropy is found to be a robust element in explaining supply chain sustainability. Furthermore, whereas co-creation and network governance reflected significant effects on negative entropy, surprisingly, open innovation demonstrated no substantial impact. This paper opens up a new front in sustainable supply chain management studies with a notable empirical study introducing negative entropy in the context of open systems theory.

Amaç : Günümüzde yapılan bazı tiroid biyopsi sonuçlarında takip mi yoksa tedavi mi konusu halen tartışmalıdır. Hangi özelliklere sahip Tiroid nodüllerinde ameliyat veya takip yapılmasında birden fazla biyopsi yapılmasının tedavideki yerini araştırmayı amaçladık Yöntem : Bir üçüncü basamak hastanede 2014-2022 yılları arasında Tiroidektomi yapılan olgular retrospektif incelendi. Preoperatif biyopsi ve postoperatif patoloji sonuçları bağımsız değişkenlerle karşılaştırıldı. Bulgular : Radyolojik TI-RADS sınıflaması yüksek, artmış nodül çapı olan ve ilaçla regüle olan grupta artmış malignite riski görüldü (p < 0.05). Önemi belirsiz atipi grubunda artmış TI-RADS postoperatif malign patolojiyle uyumlu bulundu. Sonuç : İlk biyopsi sonucu cerrahi açıdan şüpheli olgularda TI-RADS sınıflaması ve nodül çapı tedavi açısından yol gösterici olabilir.

Because of increasing life expectancy, there is an increasing number of cognitively impaired older individuals undergoing surgeries such as groin hernia repair. Here, we evaluated the effects of cognitive status on postoperative complication rates in patients undergoing groin hernia repair using various anesthesia techniques. We also analyzed the rate of same-day hernia surgery in patients with cognitive decline.Patients who presented to our general surgery clinic for unilateral or bilateral inguinal or femoral hernia were prospectively classified into general (group 1), local (group 2), and spinal (group 3) anesthesia groups. The Mini-Mental State Examination (MMSE) was used for preoperative evaluation of each patient's cognitive status. The Visual Analog Scale (VAS) was used to evaluate postoperative pain. Groups were compared in terms of age, MMSE and VAS scores, cognitive decline and complication rates, and surgery duration.In total, 33 (35.1%), 30 (31.9%), and 31 (33.0%) of 94 patients underwent surgery using general, local, and spinal anesthesia, respectively. The mean MMSE score did not differ among groups (p = 0.518). Cognitive decline was present in 18 (19.2%) patients, and the proportion did not significantly differ among groups. The complication rate did not differ between patients with and without cognitive decline. The mean surgery duration was similar among the three groups (p = 0.127). Group 2 had a lower mean postoperative VAS score, compared with the other groups (p 0.001). Complications because of anesthesia and surgery were significantly more common in group 3 than in the other groups (p = 0.025). In the local anesthesia group, 7 patients had cognitive decline and 22 patients had normal cognition. There were no significant differences between patients with and without cognitive decline in terms of mean surgery duration (50.3 ± 15.4 min vs. 45.2 ± 10.7 min; p = 0.338) or mean VAS score (3.14 ± 0.90 vs. 3.13 ± 0.77; p = 0.985). Among the 22 and 7 patients without and with cognitive decline, 11 (50%) and 0 patients were discharged on the same day (p = 0.025). In the local anesthesia group, the respective median ages were 70, 52, and 59 years for patients with cognitive decline, patients with normal cognition discharged on the same day, and patients with normal cognition who were not discharged on the same day (p = 0.001).Groin hernia repair was successfully performed under local anesthesia in all patients, including older patients with cognitive decline. Patients with cognitive decline were not discharged on the day of surgery, although the mean surgery duration and postoperative VAS score did not differ between patients with and without cognitive decline. Prolonged hospitalization in patients with cognitive decline may be related to their advanced age. Further studies are needed to determine the safety of same-day surgery in patients with cognitive decline.

Zirconium metal-organic frameworks (MOFs) can be promising adsorbents for various applications as they are highly stable in different chemical environments. In this work, a collection of Zr-MOFs comprised of more than 100 materials is screened for CF4/CH4, CH4/H-2, and CH4/N-2 separations using atomistic-level simulations. The top three MOFs for the CF4/CH4 separation are identified as PCN-700-BPDC-TPDC, LIFM-90, and BUT-67 exhibiting CF4/CH4 adsorption selectivities of 4.8, 4.6, and 4.7, CF4 working capacities of 2.0, 2.0, and 2.1 mol kg(-1), and regenerabilities of 85.1, 84.2, and 75.7%, respectively. For the CH4/H-2 separation, MOF-812, BUT-67, and BUT-66 are determined to be the top performing MOFs demonstrating CH4/H-2 selectivities of 61.6, 36.7, and 46.2, CH4 working capacities of 3.0, 4.1, and 3.4 mol kg(-1), and CH4 regenerabilities of 70.7, 82.7, and 74.7%, respectively. Regarding the CH4/N-2 separation, BUT-67, Zr-AbBA, and PCN-702 achieving CH4/N-2 selectivities of 4.5, 3.4, and 3.8, CH4 working capacities of 3.6, 3.9, and 3.5 mol kg(-1), and CH4 regenerabilities of 81.1, 84.0, and 84.5%, in successive order, show the best overall separation performances. To further elucidate the adsorption in top performing adsorbents, the adsorption sites in these materials are analyzed using radial distribution functions and adsorbate density profiles. Finally, the water affinities of Zr-MOFs are explored to comment on their practical use in real gas separation applications. Our findings may inspire future studies probing the adsorption/separation mechanisms and performances of Zr-MOFs for different gases., European Union (EU); Horizon 2020; European Research Council (ERC); Research and Innovation Programme; ERC-2017-Starting Grant; COSMOS

Background: Thyroid nodules are mostly benign. Although it varies by region, 5.4% of nodules in men and 6.5% of nodules in women may be malignant. In rural regions where a radiologist, an endocrine surgeon, a cytologist, and an endocrinologist are not present, difficulties may be experienced in the management of thyroid nodules. Objectives: This present study aims to determine if it is possible to comment on whether the nodule is malignant by evaluating the biological markers in patients with thyroid nodules. Methods: We reviewed retrospectively the data of patients between January 2019 and September 2020 who underwent total thyroidectomy in terms of thyroid ultrasonography results, thyroid fine-needle aspiration biopsy results, neutrophil, platelet, lymphocyte, red blood cell, and mean erythrocyte volume (MCV) values, histopathological examination results of thyroid specimens. Subsequently, we calculated Mentzer index, Systemic immune-inflammatory index, and neutrophil-lymphocyte ratio for each patient. Results: 140 patients were included in the study. 110 (78.6%) of the patients were female and 30 (21.4%) were male. The mean age of the patients was 48 ± 12.5 (20-76). There was no statistically significant difference in Mentzer index, Systemic inflammatory index, and neutrophil-lymphocyte ratios between patients with malignant and benign thyroid nodules. Conclusion: Biological markers have limited predictive power in the management of thyroid nodules. Therefore, the use of biomarkers that we have studied in the treatment of thyroid nodules does not seem possible at present.