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Your search keyword '"Hajizadeh, Soroush"' showing total 9 results
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9 results on '"Hajizadeh, Soroush"'

1. APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Author

Jackson, Rosemary J., Keiser, Megan S., Meltzer, Jonah C., Fykstra, Dustin P., Dierksmeier, Steven E., Hajizadeh, Soroush, Kreuzer, Johannes, Morris, Robert, Melloni, Alexandra, Nakajima, Tsuneo, Tecedor, Luis, Ranum, Paul T., Carrell, Ellie, Chen, YongHong, Nishtar, Maryam A., Holtzman, David M., Haas, Wilhelm, Davidson, Beverly L., and Hyman, Bradley T.

Published
2024
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3. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Author

Yonker, Lael M., Gilboa, Tal, Ogata, Alana F., Senussi, Yasmeen, Lazarovits, Roey, Boribong, Brittany P., Bartsch, Yannic C., Loiselle, Maggie, Rivas, Magali Noval, Porrit, Rebecca A., Lima, Rosiane, Davis, Jameson P., Farkas, Eva J., Burns, Madeleine D., Young, Nicola, Mahajan, Vinay S., Hajizadeh, Soroush, Lopez, Xcanda I. Herrera, Kreuzer, Johannes, Morris, Robert, Martinez, Enid E., Han, Isaac, Griswold, Kettner, Jr., Barry, Nicholas C., Thompson, David B., Church, George, Edlow, Andrea G., Haas, Wilhelm, Pillai, Shiv, Arditi, Moshe, Alter, Galit, Walt, David R., and Fasano, Alessio

Subjects
Gastrointestinal mucosa -- Health aspects -- Physiological aspects, Membrane proteins -- Health aspects -- Physiological aspects, Pediatric research, Health care industry
Abstract

BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date. METHODS. Here, we analyzed biospecimens from 100 children: 19 with MIS-C, 26 with acute COVID-19, and 55 controls. Stools were assessed for SARS-CoV-2 by reverse transcription PCR (RT-PCR), and plasma was examined for markers of breakdown of mucosal barrier integrity, including zonulin. Ultrasensitive antigen detection was used to probe for SARS-CoV-2 antigenemia in plasma, and immune responses were characterized. As a proof of concept, we treated a patient with MIS-C with larazotide, a zonulin antagonist, and monitored the effect on antigenemia and the patient's clinical response. RESULTS. We showed that in children with MIS-C, a prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, with subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, leading to hyperinflammation. The patient with MIS-C treated with larazotide had a coinciding decrease in plasma SARSCoV-2 spike antigen levels and inflammatory markers and a resultant clinical improvement above that achieved with currently available treatments. CONCLUSION. These mechanistic data on MIS-C pathogenesis provide insight into targets for diagnosing, treating, and preventing MIS-C, which are urgently needed for this increasingly common severe COVID-19-related disease in children., Introduction Most children who are acutely infected with SARS-CoV-2 develop mild upper respiratory symptoms or experience asymptomatic infection. Several days to weeks after resolution of the initial infection, some of [...]

Published
2021
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5. Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

Author

Sanidas, Ioannis, primary, Lee, Hanjun, additional, Rumde, Purva H., additional, Boulay, Gaylor, additional, Morris, Robert, additional, Golczer, Gabriel, additional, Stanzione, Marcello, additional, Hajizadeh, Soroush, additional, Zhong, Jun, additional, Ryan, Meagan B., additional, Corcoran, Ryan B., additional, Drapkin, Benjamin J., additional, Rivera, Miguel N., additional, Dyson, Nicholas J., additional, and Lawrence, Michael S., additional

Published
2022
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6. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

Author

Boribong, Brittany Phatana, primary, LaSalle, Thomas James, additional, Bartsch, Yannic C., additional, Ellett, Felix, additional, Loiselle, Maggie E., additional, Davis, Jameson P., additional, Gonye, Anna L. K., additional, Hajizadeh, Soroush, additional, Kreuzer, Johannes, additional, Pillai, Shiv, additional, Haas, Wilhelm, additional, Edlow, Andrea, additional, Fasano, Alessio, additional, Alter, Galit, additional, Irimia, Daniel, additional, Sade-Feldman, Moshe, additional, and Yonker, Lael M., additional

Published
2022
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7. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

Author

Boribong, Brittany P., primary, LaSalle, Thomas J., additional, Bartsch, Yannic C., additional, Ellett, Felix, additional, Loiselle, Maggie E., additional, Davis, Jameson P., additional, Gonye, Anna L. K., additional, Hajizadeh, Soroush, additional, Kreuzer, Johannes, additional, Pillai, Shiv, additional, Haas, Wilhelm, additional, Edlow, Andrea, additional, Fasano, Alessio, additional, Alter, Galit, additional, Irimia, Daniel, additional, Sade-Feldman, Moshe, additional, and Yonker, Lael M., additional

Published
2021
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8. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

Author

Guo, Hongshan, primary, Golczer, Gabriel, additional, Wittner, Ben S., additional, Langenbucher, Adam, additional, Zachariah, Marcus, additional, Dubash, Taronish D., additional, Hong, Xin, additional, Comaills, Valentine, additional, Burr, Risa, additional, Ebright, Richard Y., additional, Horwitz, Elad, additional, Vuille, Joanna A., additional, Hajizadeh, Soroush, additional, Wiley, Devon F., additional, Reeves, Brittany A., additional, Zhang, Jia-min, additional, Niederhoffer, Kira L., additional, Lu, Chenyue, additional, Wesley, Benjamin, additional, Ho, Uyen, additional, Nieman, Linda T., additional, Toner, Mehmet, additional, Vasudevan, Shobha, additional, Zou, Lee, additional, Mostoslavsky, Raul, additional, Maheswaran, Shyamala, additional, Lawrence, Michael S., additional, and Haber, Daniel A., additional

Published
2021
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9. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children.

Author

Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, and Yonker LM

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a delayed-onset, COVID-19-related hyperinflammatory systemic illness characterized by SARS-CoV-2 antigenemia, cytokine storm and immune dysregulation; however, the role of the neutrophil has yet to be defined. In adults with severe COVID-19, neutrophil activation has been shown to be central to overactive inflammatory responses and complications. Thus, we sought to define neutrophil activation in children with MIS-C and acute COVID-19. We collected samples from 141 children: 31 cases of MIS-C, 43 cases of acute pediatric COVID-19, and 67 pediatric controls. We found that MIS-C neutrophils display a granulocytic myeloid-derived suppressor cell (G-MDSC) signature with highly altered metabolism, which is markedly different than the neutrophil interferon-stimulated gene (ISG) response observed in pediatric patients during acute SARS-CoV-2 infection. Moreover, we identified signatures of neutrophil activation and degranulation with high levels of spontaneous neutrophil extracellular trap (NET) formation in neutrophils isolated from fresh whole blood of MIS-C patients. Mechanistically, we determined that SARS-CoV-2 immune complexes are sufficient to trigger NETosis. Overall, our findings suggest that the hyperinflammatory presentation of MIS-C could be mechanistically linked to persistent SARS-CoV-2 antigenemia through uncontrolled neutrophil activation and NET release in the vasculature., One Sentence Summary: Circulating SARS-CoV-2 antigen:antibody immune complexes in Multisystem Inflammatory Syndrome in Children (MIS-C) drive hyperinflammatory and coagulopathic neutrophil extracellular trap (NET) formation and neutrophil activation pathways, providing insight into disease pathology and establishing a divergence from neutrophil signaling seen in acute pediatric COVID-19.

Published
2021
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