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Abstract Background Nausea and vomiting during pregnancy (NVP) is one of the most common complication of pregnancy. The present study was aimed to determine the association between vomiting during pregnancy and adverse birth outcomes. Methods A cross-sectional study was conducted on 3649 pregnant women across 11 provinces of Iran. Cluster sampling method was used to select samples and data collection was done using family record and face-to-face interviews. Data were analyzed by logistic regression, using STATA14.2 software. Results The prevalence of vomiting during pregnancy was 9.7% (95% CI: 8.8, 10.7), with an increasing trend by birth cohort. After adjusting for other confounders, the prevalence of vomiting revealed a decreasing trend by body mass index (OR = 0.63, 95%CI: 0.53, 0.78, P-trend 3 year=1.63). Multivariate analyses showed that the odds of stillbirth (AOR = 1.61, 95% CI: 1.17, 2.19) and the odds of infant mortality (AOR = 1.78, 95% CI: 1.29, 2.45) were significantly increased in women with daily vomiting during pregnancy. The odds of vomiting during pregnancy was significantly shown to reduce the odds of abortion by 45%. Conclusion The prevalence of NVP was shown to have an increasing trend in Iran. This complication is associated with many adverse health outcomes during pregnancy and negatively affect maternal and fetal health. Given the importance of pregnancy period, nutrition education and increase the awareness of pregnant women towards NVP, especially pre-pregnancy training is suggested.

Introduction: Motivation in education and learning are significant challenges in clinical education. This study aimed to determine the relationship between clinical education status and academic motivation among clinical-stage medical students Gonabad University of Medical Sciences. Method: This cross-sectional study was conducted with 198 medical interns and residents at Gonabad University of Medical Sciences during the academic year 2021-2022 using a census method. Data collection tools included the Clinical Education Status Questionnaire and the Harter Academic Motivation Questionnaire. Descriptive statistics (mean and standard deviation) were used to describe the participants' status, and data were analyzed using independent t-tests, Pearson, and Spearman correlation tests. Results: The mean score for clinical education status among interns was 51.93 ± 16.56, while for residents, it was 12.93 ± 08.12. The mean score for academic motivation among interns was 102.07 ± 11.30, and for residents, it was 100.07 ± 11.54. Overall, the clinical education status averaged 93.31, indicating a relatively moderate level and Academic motivation averaged 101.05 ± 11.44, indicating a high level, with a significant correlation observed between clinical education status and academic motivation (r = 0.454). Conclusion: Given the weakness in the clinical education status, as well as the direct relationship between clinical education status and academic motivation, it is recommended that university officials, particularly in the educational and clinical departments, focus on special attention and planning to improve the clinical education status at the university.

Background: Retinopathy of prematurity (ROP) is one of the common complications in premature neonates. ROP examination is one of the most important examinations for premature babies, which is associated with pain and can be very annoying. This study aimed to compare the effectiveness of pharmacological and non-pharmacological methods in reducing the pain of ROP examination. Materials and Methods: This study was conducted as a double-blind, randomized control trial on 300 ROP examinations of patients who were hospitalized in the NICU department of Mahdieh Hospital in Tehran. The neonates were randomly selected into three groups, and ketamine 2mg/kg nasally, fentanyl two µg/kg nasally10minutes before an examination, and acetaminophen 2drop/kg orally 30 minutes before each examination were given to each neonate as two pharmacological groups. In the non-pharmacological group, infants received saddling-pacifier oral sucrose 25% 0.5cc 2 minutes before examination. Pain was assessed based on PIPP (premature infant pain index). Results: The amount of pain after using oral sucrose was significantly lower than the ketamine-acetaminophen (P-value=0.011) and fentanyl-acetaminophen (P-value=0.027) groups, but there was not a statistically significant difference between the two groups of ketamine-acetaminophen and fentanyl-acetaminophen (P-value=0.953). The hypoxia was more prevalent in the ketamine-acetaminophen group (18.8%), and the least hypoxia occurred in the oral sucrose treatment group (7%) (P-value=0.028). Conclusion: It is concluded that the effect of non-pharmacological drugs is greater than pharmacological drugs in reducing the pain of neonates during ROP examination. The effect of oral sucrose in reducing pain was more significant than ketamine-acetaminophen and fentanyl-acetaminophen. However, there was no significant difference between the two groups of ketamine-acetaminophen and fentanyl-acetaminophen.

Background: Legg-Calvé-Perthes disease (LCPD) presents in childhood with idiopathic avascular necrosis of the femoral head(s), which can lead to disability and the need for corrective surgery at an early age. Bisphosphonates are a group of drugs that prevent osteoclastic bone resorption and may be helpful in the treatment of LCPD. So far, no trial has been conducted to investigate the effect of monthly intravenous pamidronate in the treatment of LCPD in children. Therefore, we assessed this issue in this study. Materials and Methods: This study was conducted as a clinical trial on children with LCPD who were referred to Mofid Children's Hospital (Iran-Tehran) during 2022 and 2023. Pamidronate was injected monthly and intravenously at a dose of 1 mg/kg/dose. Both groups were the same in terms of the type of treatment received (except pamidronate), the number of visits, and other follow-up parameters. The study was conducted for one year. The significance level was considered less than 0.05. Results: Forty-seven patients were included in the study. Twenty-one (60%) were in the pamidronate group, and 26 (40%) were in the control group. The mean age in the intervention group was 6.19 ± 1.69 years, and it was 6.15 ± 1.85 years in the control group (P-value=0.944). There was no statistically significant difference in children's gender (P-value = 0.731). Patients with pamidronate had a better overall score than the control group. The overall score in the pamidronate group was 2.37 more than the control group, but this difference was not statistically significant (P value=0.753). The scores of pain, lameness, walking, distance, squat, cross leg, and range of motion (ROM) in the pamidronate group were not significantly different from the control group (P value>0.05). Conclusion: Pamidronate can improve the clinical results of children with Legg-Calve-Perthes disease, and it is recommended that this drug be used along with the usual treatments for these patients.

Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation of polyunsaturated fatty acids (PUFAs). Despite its significance, the precise molecular mechanisms underlying ferroptosis remain elusive, particularly concerning their impact on membrane properties. This study aimed to investigate the biophysical changes in plasma membranes due to lipid peroxidation during ferroptosis and their impact on the uptake of doxorubicin (DOX), a potent anticancer agent linked to ferroptosis. Using all-atom molecular dynamics simulations, we compared native red blood cell membranes (protein-free domains) with a ferroptosis model, in which PUFAs were replaced with hydroperoxide derivatives. Our findings reveal that the ferroptotic membrane exhibits decreased thickness and increased lipid area while maintaining overall integrity. The hydroperoxide groups localized in the disordered tail regions, enhancing tail mobility and facilitating hydrogen bonding. Lipid lateral diffusion was significantly altered, both layers of the ferroptotic membrane exhibited slower diffusion rates compared to the native membrane. Furthermore, lipid oxidation affected diffusion activation energies. Importantly, we found that DOX could penetrate the oxidized ferroptosis membrane with a lower free-energy barrier (∆GPB) of approximately 38 kJ.mol−1. Consequently, DOX’s permeability was approximately seven orders of magnitude higher than that of the native membrane. In summary, lipid peroxidation during ferroptosis induces extensive structural and dynamic changes, influencing membrane behavior and potentially offering insights that could inform future therapeutic strategies.

Abstract Background Children with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted. Methods The present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria. Results Research on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health‐related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels. Conclusion The use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD.

Satellite constellations consist of similar satellites distributed in a specific orbital pattern to accomplish a joint mission. They are commonly used for global telecommunications, positioning, and remote sensing missions. This article utilizes a scientometric approach to analyze the structure and scientific mapping of "satellite constellations" worldwide, focusing on two leading countries: the United States and China. Additionally, a comparison is made between the United States, China, and global research outputs.The research encompasses all scientific documents in the "satellite constellations" field indexed in the Scopus database from 1969 to 2023. Knowledge maps (thematic subfields) and international cooperation maps are generated using Bibexcel and VOSviewer software. The number of documents published in this period includes 14,346 globally, with 3,738 from the United States and 3,369 from China.The findings reveal that the United States, China, Germany, Italy, and the United Kingdom are leaders in this field. The trend of scientific production in this area is increasing globally, indicating its importance and attractiveness. Conference papers constitute the most significant number of publications worldwide and in the United States, whereas, in China, most documents are journal articles. The top scientific production institutions globally include the National Aeronautics and Space Administration (NASA), the Chinese Academy of Sciences, the German Aerospace Center, Wuhan University, and the European Space Research and Technology Centre.

Abstract Background Releasing of metal ions might implicate in allergic reaction as a negative subsequent of the corrosion of Stainless Steel (SS304) orthodontic wires. The aim of this study was to evaluate the corrosion resistance of zinc-coated (Zn-coated) SS orthodontic wires. Methods Zinc coating was applied on SS wires by PVD method. Electrochemical impedance spectroscopy (EIS), Potentiodynamic polarization tests and Tafel analysis methods were used to predict the corrosion behavior of Zn-coated and uncoated SS wires in both neutral and acidic environments. Results The values of Ecorr ,icorr and Rct ,which were the electrochemical corrosion characteristics, reported better corrosion behavior of Zn-coated SS wires against uncoated ones in both artificial saliva and fluoride-containing environments. Experimental results of the Tafel plot analyses were consistent with that of electrochemical impedance spectroscopy analyses for both biological solutions. Conclusion Applying Zn coating on bare SS orthodontic wire by PVD method might increase the corrosion resistance of the underlying stainless-steel substrate.

Background and purpose: In recent years, there has been a decrease in the fertility rate in the country, including in Mazandaran province. A reduction in population growth led to economic, social, and cultural changes and a decrease in the political and military power of the country. Therefore, the goal of this study is to analyze the mixed regression model of the factors related to the motivation of childbearing in couples referring to the health centers of Mazandaran province. Materials and methods: This cross-sectional-analytical study was conducted in four cities of Mazandaran province between October and March 2022 on 468 couples using a multi-stage sampling method. Data collection was done with socio-demographic questionnaires, Naghibi et al. motivation childbearing, and Rammstedt and John Neo Personality Questionnaire. Data analysis was done with SPSS version 22 software. The significance level was considered 0.05 in all tests. Statistical indicators of number and percentage were used to describe qualitative variables, and mean and standard deviation were used for quantitative variables. To investigate the effect of all factors on the couple's motivation to have children, given that the study is a couple, a mixed linear regression model was used using the regression method. Results: In this study, the response rate was 93.2%, and the final analysis was performed on the information obtained from 468 couples. The mean and standard deviation of the age of women and men were 35.64±6.76 and 39.75±8.29, respectively, and the length of marriage was 12.85±7.81. In this study, 261 (55.8%) housewives, 167 (35.7%) working men, 329 (71.3%) of women with a history of cesarean section, 54 (11.5%) of childless couples and 372 (79.5 percent) of the couples lived in the urban. The mean score of motivation childbearing for women and men was 60.82±9.36 and 60.58±8.29, respectively. Based on the adapted regression coefficient, couples with favorable socioeconomic status (P

Background: Carotid intima medial thickness (CIMT) is a reliable marker for assessing large and medium blood vessel atherosclerosis. This study aimed to investigate the carotid intima-media thickness in children with nephrotic syndrome admitted to Mofid Hospital during 2019-2021. Materials and Methods: This case-control study was conducted in Mofid Hospital for two years (2019-2021). The samples were selected in the case group from hospitalized children with nephrotic syndrome and the control group from hospitalized children without nephrotic syndrome. Results: The mean thickness of the right and left carotid intima-media thickness in the case group was 0.07 ± 0.43 and 0.43 ± 0.07 millimeters, respectively, and these two values were lower and equal to 0.42 ± 0.05 millimeters in the control group, respectively (P-value= 0.02, P-value = 0.016). There was a negative and significant relationship between the level of phosphate and CIMT on the left side, and with an increase of one unit in phosphate, the value of left CIMT decreased by 0.277 times. Also, there was a negative and significant relationship between right CIMT and the level of albumin at discharge time, so with an increase of one unit in albumin, the value of right CIMT decreased by 0.256 times. Conclusion: It is concluded that nephrotic syndrome causes an increase in CIMT and vascular damage in children. The increase of blood albumin and phosphate was associated with the decreased CIMT.

Abstract Background In regions endemic for tuberculosis and brucellosis, distinguishing between tuberculous meningitis (TBM) and brucella meningitis (BM) poses a substantial challenge. This study investigates the clinical and paraclinical characteristics of patients with TBM and BM. Methods Adult patients diagnosed with either TBM or BM who were admitted to two referral hospitals between March 2015 and October 2022, were included, and the characteristics of the patients were analyzed. Results Seventy patients formed the study group, 28 with TBM and 42 with BM, were included. TBM patients had a 2.06-fold (95% CI: 1.26 to 3.37, P-value: 0.003) higher risk of altered consciousness and a 4.80-fold (95% CI: 1.98 to 11.61, P-value:

Abstract Objectives Continuous curriculum improvements reveal the dedication of policy-makers to raising the quality of education and student learning. This study aims to report the impact of curriculum changes to the three-month pediatric course curriculum at Shahid Beheshti University of Medical Sciences (SBMU) on the satisfaction levels of medical students. Methods One hundred eighteen 4th-5th years medical students, who had completed their pediatric clinical rotation in SBMU-affiliated teaching hospitals including Mofid Children Hospital, Loghman Hakim Hospital, Shohada-e-Tajrish Hospital, and Imam Hossein Hospital from January to December 2022 were included in this cross-sectional study. After obtaining informed consent, a questionnaire was sent out to all participants, that included 27 statements about the impact of the modified curriculum on their satisfaction with their learning and performance. SPSS version 22 was used to analyze the data. Results The level of satisfaction of trainees from attending clinics was 82-56%, prior introduction to the course was about 82%, and attending general hospitals (all hospitals except Mofid Children hospital, which is the only children hospital affiliated to SBMU) was 82-97%. The quality of patients-based learning was reported in terms of attendance at morning report sessions which was 92.3%, attendance at ward rounds, which was 71.8%, and attendance at clinics, which was 62.4%. The satisfaction rate from the senior attending mentor was 96.5%. The satisfaction rate of the pathology course was 67.2%, and the radiology was 82.4%. The satisfaction level of medical students from the infectious disease department was 70% and the gastroenterology department was 83.8%. The level of satisfaction with the implementation of the twelve-week program was 68.7%, with the expressiveness and usability of the presentation of materials was 53.9%, with the compatibility of the exams with the presented materials was 92%, and withholding weekly exams was 86.8%. The satisfaction rate of using the materials presented in the final exam in the digestive department and the infectious department was 85% and 68%, respectively. The overall satisfaction rate of the training course was 76.66%. Conclusion The results provide vital insights for improving medical education. According to this study, medical student satisfaction with the pediatric curriculum after its recent revisions was in a satisfactory range. Attendance at clinics, information sharing, patient-based learning, practical training, attending mentorship, curriculum clarity, and alignment with student expectations all contributed to participants' high levels of satisfaction.

Background: Anesthesia is a significant development of modern medicine that makes diagnostic and therapeutic procedures with unbearable pain or discomfort feasible. Like most medical procedures, anesthesia is not free of complications. It is shown that many patients suffer from anxiety due to fear of anesthesia complications before operation. Increasing patients’ knowledge of these complications can help them reduce their anxiety. This study aimed to assess the patients’ knowledge and attitude toward anesthesia complications and their relationship with demographic features and previous anesthesia experience to ensure a helpful and informative preoperative visit. Methods: This is an original study conducted on patients referred to our anesthesia clinic for a preoperative visit, completing a questionnaire about demographic features, previous anesthesia experience, knowledge, and attitude toward anesthesia complications. The results were expressed as frequencies and percentages. T-test, Pearson correlation, and linear regression were used to find the significance of the study parameters. Results: Four hundred patients entered the study. Patient demographics were as follows: 260 (65.0%) female, 251 (62.75%) high school-graduated or below, mean (SD) age 42.75± 13.62 years. 260(65.0%) patients had previous anesthesia experience. Patients’ mean (SD) knowledge score was 6.83 ± 4.18 out of 19 questions and the mean (SD) attitude score was 54.26 ± 6.59. The patients were most aware of postoperative delirium (72.8%), nausea and vomiting (66.0%), feeling pain during surgery (59.5%), and death (52.3%) as general anesthesia complications. There was a significant relationship between the level of knowledge and the female sex (p-value= 0.03). University education had a significant relationship with knowledge and attitude (both p-values ≤ 0.001). There was a significant correlation between knowledge and attitude (Pearson correlation= 0.461, p-value ≤ 0.001), as well. Conclusion: Unfortunately, the knowledge about anesthesia complications in outpatients referring to our tertiary care center was poor. Women and university-educated patients had a higher level of knowledge. In contrast, most patients had a positive attitude toward anesthesia which was significantly higher in university-educated patients. It is shown that with the increase in the level of knowledge, attitude scores increased as well.

Traumatic brain injury (TBI) is one of the most causes of death and disability among people, leading to a wide range of neurological deficits. The important process of neurogenesis in the hippocampus, which includes the production, maturation and integration of new neurons, is affected by TBI due to microglia activation and the inflammatory response. During brain development, microglia are involved in forming or removing synapses, regulating the number of neurons, and repairing damage. However, in response to injury, activated microglia release a variety of pro-inflammatory cytokines, chemokines and other neurotoxic mediators that exacerbate post-TBI injury.These microglia-related changes can negatively affect hippocampal neurogenesis and disrupt learning and memory processes. To date, the intracellular signaling pathways that trigger microglia activation following TBI, as well as the effects of microglia on hippocampal neurogenesis, are poorly understood. In this review article, we discuss the effects of microglia-induced neuroinflammation on hippocampal neurogenesis following TBI, as well as the intracellular signaling pathways of microglia activation.

Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase belonging to the Rho family. It acts as a binary molecular switch regulating several cellular functions, including cell adhesion and migration. Malfunctions due to the P29S mutation in Rac1 increase the stability of the activated form of Rac1. This sustained activation can drive aberrant cellular processes associated with cancer, such as cell proliferation, survival, and migration. Therefore, finding an inhibitor that can inhibit the mutant form of the protein is very important. Rhein, a natural compound with diverse pharmacological properties, has been studied in relation to Rac1. However, specific interactions between Rhein and Rac1 have not been examined. In this study, we investigated the potential of Rhein, a natural compound, as an inhibitor of two forms of Rac1: the wild type and the P29S mutation, using molecular dynamics simulations. Results indicated that the P29S mutation led to structural changes in the Rac1 protein, which resulted in greater accessibility of the Rhein to the active site. In addition, the binding energy of Rhein to mutant Rac1 was more negative than the native protein. Therefore, it seems that the Rhein has a better inhibitory effect on the P29S-mutated form of the Rac1 protein.

Renewable electrical energy (such as: solar and wind energies) generation in microgrids (MGs), is gaining attention to reduce greenhouse gas emissions. Microgrid operators (MOs) aim to create self-sufficient, environmentally sustainable grids, increasing the capacity of renewable energy sources (RESs) by up to 100%. Despite of the benefits of this trend, challenges arise from non-controlled characteristics of these power generations and their seasonal variations, causing fluctuations and renewable energy curtailment. Although the technical solutions; such as: the demand response (DR) programs, and the conventional electrical energy storage systems (EESSs) can help, however those may face limitations in countries with high seasonal energy generation and consumption variations. This paper introduces cryptocurrency mining loads (CMLs) as innovative virtual energy storage systems (VESSs), named cryptocurrency energy storage systems (CESSs). It proposes a structure to store excess renewable energy in cryptocurrency units (CCUs) like Bitcoin (BTC). CESSs can be charged during off-peak intervals and, conversely, they discharge during high-demand periods to reduce the overall operational cost of MGs. Furthermore, it presents a new energy management system (EMS) formulation for the optimal operation of MGs in the presence of CESSs, providing an opportunity to generate additional electricity from RESs and to mitigate renewable energy curtailment. This paper explores the optimal operation conditions of both islanded and grid-connected MG with the proposed CESS. Utilizing a dataset from an island in Finland as a practical MG, its effectiveness is demonstrated through several case studies. The results of one case study in this paper demonstrate that the proposed CESS can decrease the operating cost of the MG by about 46.5%. Additionally, it is showed that by application of CESS the renewable energy curtailment is significantly reduced, and approached zero.

Superparamagnetic nanoparticles (SPMNPs) have attracted considerable attention in biomedicine, particularly magnetic hyperthermia for cancer treatment. However, the development of efficient and eco-friendly methods for synthesizing SPMNPs remains a challenge. This study reports on a green synthesis approach for SPMNPs using pomegranate peel extract as a stabilizing agent. The effects of various synthesis parameters, including the type of precipitating agent (NH3 and NaOH), N2 gas, extract volume, and pH, were systematically investigated with regard to the size, morphology, and magnetic properties of the nanoparticles. The results showed that reducing the volume of the extract increased the saturation magnetization of the nanoparticles. N2 gas was found to be essential in preventing the oxidation of the nanoparticles. The type of precipitating agent also affected the size and magnetization of the nanoparticles, with NaOH leading to the synthesis of SPMNPs with higher magnetization (∼4 times) compared to NH3. Additionally, nanoparticles synthesized at pH 10 exhibited higher magnetization than those synthesized at pH 8 and 12. In conclusion, the optimized synthesis conditions significantly affected the magnetization and stability of SPMNPs. These nanoparticles are suitable for use in magnetic nanofluid hyperthermia applications.

Abstract Background Toxoplasma gondii is a widely prevalent zoonotic protozoan parasite in humans and warm‐blooded animals worldwide. Infection of humans by this parasite can result in severe clinical symptoms, particularly in individuals with congenital toxoplasmosis or immunocompromised patients. Contamination mainly occurs through foodborne routes, especially the consumption of raw or undercooked meat from animals. Objectives The aim of this study was to use PCR to detect T. gondii in tissues and organs of buffaloes and cattle slaughtered at Tabriz slaughterhouse, in Iran. Methods Fifty grams of heart, thigh, diaphragm and tongue from 50 buffaloes and 100 cattle slaughtered at the Tabriz industrial slaughterhouse were selected for sampling using a combination of convenience sampling. The samples were tested using a previously published PCR method. Results Out of the 150 animal samples, T. gondii was detected in 10 (6.7%, 95%CI: 3.2–11.9), including one buffalo (2%, 95%CI: 0.1–10.6) and nine cattle (9%, 95%CI: 4.2–16.4). There was no statistically significant difference in the rate of T. gondii infection among cattle based on age and sex (p > 0.05). Conclusions The results indicated a potential risk of T. gondii transmission to humans through the consumption of infected meat. Therefore, appropriate and effective preventive measures should be taken to limit the transmission of this parasite to humans, and the consumption of raw and undercooked meat should be discouraged.

Abstract Background Sarcocystis is a food‐borne zoonotic protozoan whose final hosts are humans, dogs, cats, and other carnivores and intermediate hosts are birds and mammals, especially humans and herbivores. Humans become infected by eating raw and undercooked meat contaminated with bradyzoites or by consuming water or food contaminated with the sporocyst stage of the parasite. Objectives The aim of this study was to investigate the effects of gamma radiation and electron beam on the survival rate of Sarcocystis bradyzoites in infected beef and to determine the effective dose. Methods Three replicates of 100 g of infected meat were treated with different doses (0.5, 1, 1.5 and 2 kGy). As a control, 20 g of contaminated meat was stored separately at 4°C. The viability of the bradyzoites after digestion in pepsin solution was assessed, stained (trypan blue) and unstained, under a stereomicroscope. To assess survival of the bradyzoites, the irradiated meat samples were fed to 30 dogs. After 10 days, faecal samples were examined for sporocysts. Results The results showed that the highest and lowest mortality rate of Sarcocystis bradyzoites in infected organs using electron beam at a dose of 2 kGy were 92.5% and 100%, respectively, and the lowest mortality rate at a dose of 0.5 kGy were 2.5% and 7.89%, respectively. Conclusion The results of statistical analysis showed that the mortality rate of Sarcocystis bradyzoites was significant between different doses of gamma ray and electron beam, so that gamma rays were better compared to electron beam in destroying Sarcocystis bradyzoites.

Time-delay fractional optimal control problems (OCPs) are an important research area for developing effective control and optimization strategies to address complex phenomena occurring in various natural sciences, such as physics, chemistry, biology, and engineering. By considering fractional OCPs with time delays, we can design control strategies that take into account the system's history and optimize its behavior over a given time horizon. However, applying the Pontryagin principle of maximization to solve these problems leads to a boundary value problem (BVP) that includes delay and advance terms, making analytical solutions difficult and demanding. To address this issue, this paper presents a precise finite difference formula to solve the aforementioned advance-delay BVP numerically. The suggested approximate method's error analysis and convergence properties are provided, and several illustrative examples demonstrate the applicability, validity, and accuracy of the proposed approach. Simulation results confirm the proposed technique's advantages for the optimal control of delay fractional dynamical equations.

Introduction: Due to the obviousness of musculoskeletal disorders in health workers, especially patient carriers, we felt it necessary to check the prevalence of musculoskeletal pain in these workers by correcting their posture. Mateials and Methods: The study is semi-experimental. First, a self-made demographic questionnaire was made on the level of awareness, and a Nordic questionnaire along with a numerical rating scale to measure the amount of pain related to musculoskeletal disorders was completed for all participants. Then, theoretical and practical interventions were carried out to correct posture using occupational medicine, ergonomics, and sports specialists, and again one month and six months later, questionnaires were completed and data were collected. In the end, data analysis was done with SPSS version 24 software. Results: Descriptive statistics show that interventions aimed at correcting postures, reduce the average pain scores for different body parts of patient carriers. The most prevalent musculoskeletal disorder was back pain. Statistical analysis showed that comparing the average score of back pain (p=0.000), neck (p=0.014), shoulder (p=0.006), knee (p=0.006), and leg (p=0.016) in patient carriers before There is a significant difference between postural correction and six months later. However, comparing the average pain score of the elbow (p=0.18), wrist (p=0.06), back (p=0.3), and thigh (p=0.08) at the end of six months after correcting the posture, no significant difference was observed. Conclusion: It seems that correcting the posture while carrying and moving the patient with the help of occupational medicine, ergonomics, and sports specialists can reduce musculoskeletal pain in medical workers, especially patient carriers. It was also seen that correcting posture has the fastest and highest effect on reducing back, neck, shoulder, knee, and leg pain.

Cryptocurrency has become a pivotal player in global financial transactions due to its decentralized mining process, which eliminates the need for intermediaries. However, the operation of cryptocurrency mining devices (CMDs) requires significant electrical power, leading to an increase in network-connected cryptocurrency mining loads (CMLs) that pose challenges for power grid operators. This paper evaluates the integration of CMLs into power grids, focusing on distribution network performance. A technology-accepted model for assessing cryptocurrency mining performance is presented, along with an analysis of the impacts of high CML penetration on power grid planning and operation. Findings reveal that high CML penetration can complicate load forecasting, congest transmission lines, and increase the coincident peak load in distribution networks. A case study of Iran’s power network indicates that CMLs account for approximately 2.8% of the nation’s electricity consumption. Furthermore, if 5% of residential customers in Tehran install CMDs, the average coincident peak demand for this group rises by 26.81%. Additionally, the average power factor of a sample CMD is about 0.99, while total current distortion and third harmonic current exceed permissible limits, indicating potential power quality issues. This study highlights the challenges posed by CMLs and proposes strategies for their sustainable integration into power grids.

Background: Neonate screening is a preventative measure that can contribute to early diagnosis of treatable diseases. Hypothyroidism in neonates is among the common preventable factors leading to intellectual disability. This study aims to describe the prevalence and experience with four-step screening to diagnose congenital hypothyroidism.Methods: The statistical population of this cross-sectional study included 392 preterm neonates (gestational ages less than 36 weeks and 6 days) in 2018-2019 from the health centers covered by Shahid Beheshti University of Medical Sciences (Tehran, Iran) who had been referred for screening. Neonates were screened in the first 3-6 days after birth and then on days 14, 42, and 72. In neonates with TSH serum levels of 10 mU/L, TSH-T4 was measured. Next, the physician decided on the medication based on the results.Results: At the primary screening of the neonates average TSH level was 2.08 ± 2.4 mU/L. Thirty-three neonates (8.4%) indicated disrupted screening results. The secondary screening of 388 neonates (98.97%) revealed an average TSH serum level of 1.9 ± 1.96 mU/L, and 19 (5.9%) indicated TSH serum levels higher than 5 (mU/L). The third screening test was performed on 382 (97.44%) of the neonates. The average TSH level was 1.3 ± 2.4 mU/L, 340 (85.96%) indicated normal levels, and 42 (11.47%) had unfavorable results. Finally, the fourth screening test was performed on 373 (95.15%) neonates. The mean TSH level was 2.21 ± 1.9 mU/L, which revealed 24 (6.12%) unfavorable test results. The percentage of hypothyroidism in neonates was 5.6% (23 cases). In this study, the prevalence of hypothyroidism was 4.33% (17 cases) in girls and 1.53% (6 cases) in boys. Conclusion: The results of this study revealed the high incidence rate of congenital hypothyroidism among preterm neonates. Therefore, preventing congenital hypothyroidism misdiagnosis requires a series of screening tests. Also, findings indicated that the results of screening tests for preterm neonates with prolonged GAs and higher birth weights are more accurate and reliable.

Inrush current is high-magnitude current drawn by power transformers upon energization. The severity of inrush current depends on factors such as the transformer’s residual flux and the voltage phase angle at the energization instant. This paper proposes a flux matching method for the energization of V/V traction transformers to mitigate inrush current. This is achieved by adjusting the residual flux of the core to an appropriate reference value and then obtaining the proper energization instant. To this end, the method only requires knowledge of nominal voltage and excitation current, eliminating the need to acquire transformer’s parameters/design information. The railway power conditioner, typically present at the low voltage side of the V/V transformer, is used as a current source to inject sinusoidal current into the transformer windings before its energization. The reference residual flux is calculated based on the circuit breaker operating characteristics. The energization instant is determined such that the adjusted flux density matches the steady-state flux expected with respect to the applied voltage. The proposed method is validated by conducting over 14,000 simulations under different conditions using PSCAD/EMTDC. The method is also implemented and successfully tested on a laboratory-scale test rig, which verifies its effectiveness in more realistic conditions.

Background: The importance of cerebral perfusion during congenital cardiac surgery, especially after hypothermic cardiopulmonary bypass (CPB) strategy, has remained a debate. In this study, we evaluated the effect of mild hypothermic CPB strategy on cerebral oximetry near-infrared spectroscopy in congenital heart defects surgery. Methods: In a randomized prospective study, the pediatrics aged two months and six years with RACHS categories I-Ⅱ for congenital heart defects surgery were randomly divided into normothermic and mild hypothermic CPB groups. The NIRS was measured in all patients via the INVOS ™ cerebral oximetry system. The perfusion and anesthesia strategies during the study were followed as standard methods. A p-value below 0.05 is considered to be a significant level. Results: Regarding cerebral oximetry, the results showed no significant difference between normothermic and mild hypothermic CPB groups. Conclusion: It can be concluded that optimizing cerebral oxygen saturation monitoring during congenital cardiac surgery can improve patient outcomes as a protective strategy.

Background and purpose: Although fear and anxiety during pregnancy can be associated with adverse pregnancy outcomes, the existing studies show various results. This study aimed to investigate the relationship between fear and anxiety of COVID-19 and childbirth experiences. Materials and methods: This longitudinal study was conducted in six cities of Mazandaran province between June 2021 to February of the same year on 278 pregnant women using a multi-stage sampling method. Data were collected using the Fear of COVID-19 questionnaire, the Anxiety of COVID-19 questionnaire, and the Vijima Childbirth Experience questionnaire. Variables were described using descriptive indices and their analysis was done using a multiple linear regression model. Results: In this study, 135 participants (48.6%) had fear of COVID-19, and 126 (45.3%) had anxiety about COVID-19. Univariate analysis showed that the fear of COVID-19 had a significant relationship with the negative experience of childbirth (P-value

One of the damaging factors for the proper functioning of telecommunication payloads are high energy ionizing particles in space, which the use of proper shield is a way to deal with it. In the design of protection, several factors, such as the type of part and the amount of weight acceptable for the payload.etc.must be taken into consideration. In recent years, in order to reduce the costs of construction and launch, the use of non-space components has been favored.Therefore, the use of shields with the suitable material in with radiation resistance, with respect to the weight budget considerations, will be one of the important challenges .In this paper, the aim is to investigate the methods of reducing the weight budget considering with respect to the radiation damage of ionizing dose. In this regard, a five-year technology development mission in the GEO orbit has been predicted, and the results of simulations and testing of aluminum and polyethylene shielding to check ionizing dose damage, according to the initial and reference weight budget, have been presented and compared. The analysis and evaluation of the test results using polyethylene protection shows a 17.21 percentage reduction between the two external and internal radiation meters.

Toxoplasmosis, caused by Toxoplasma gondii, is an important zoonotic disease produced by ingesting food contaminated with oocysts and tachyzoites of this parasite and as well as congenital infection occurs unintentionally in humans by the placenta. The study of this parasite in pre-pregnancy women is of paramount importance because of abortion, hydrocephalus, microcephalus, intracranial calcifications, retinochoroiditis, strabism, blindness, epilepsy, psychomotor and mental retardation. Therefore, the present study aims to investigate the seroepidemiology of T. gondii infection in pre-pregnancy women referring to private laboratories in Yazd city. In this study, blood was sampled from 185 pre-pregnancy women. Anti-T. gondii IgG and IgM antibodies were determined in separated serum samples using the ELISA test. Data were entered in Excel 2016 to calculate the percentages. The results indicated that 50 (27.03%) out of 185 pregnant women were positive for anti-Toxoplasma antibodies. Among these women, IgG and IgM antibodies were observed in 35 (18.91%) and 14 (7.56%) subjects, respectively. Both antibodies were found in the serum of one participant (0.5%). Since the anti-T. gondii antibody level is low in the blood serum of pregnant women in this region; pregnant women are recommended to avoid contact with cats, restrain from eating raw meat and food during pregnancy, and be tested for T. gondii at least once, particularly in the first trimester of pregnancy.