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1. Computer-aided diagnosis for the resect-and-discard strategy for colorectal polyps: a systematic review and meta-analysis

Author

Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Massimi, Davide, Djinbachian, Roupen, Takishima, Kazumi, Mochizuki, Kenichi, Miyata, Yuki, Mochida, Kentaro, Akimoto, Yoshika, Kuroki, Takanori, Morita, Yuriko, Shiina, Osamu, Kato, Shun, Barua, Ishita, Holme, Øyvind, Wieszczy, Paulina, Løberg, Magnus, Kalager, Mette, Gulati, Shraddha, Williams, Sophie, Hayee, Bu, Patel, Mehul, Gunasingam, Nishmi, Kent, Alexandra, Emmanuel, Andrew, Haji, Amyn, Itoh, Hayato, Mori, Kensaku, Nemoto, Tetsuo, Munck, Carl, Aksel Nilsen, Jens, Astrup Hvattum, Stine, Oskar Frigstad, Svein, Tandberg, Petter, Lanza, Davide, Bonanno, Giacomo, Hassan, Cesare, Rizkala, Tommy, Mori, Yuichi, Spadaccini, Marco, Misawa, Masashi, Antonelli, Giulio, Rondonotti, Emanuele, Dekker, Evelien, Houwen, Britt B S L, Pech, Oliver, Baumer, Sebastian, Li, James Weiquan, von Renteln, Daniel, Haumesser, Claire, Maselli, Roberta, Facciorusso, Antonio, Correale, Loredana, Menini, Maddalena, Schilirò, Alessandro, Khalaf, Kareem, Patel, Harsh, Radadiya, Dhruvil K, Bhandari, Pradeep, Kudo, Shin-ei, Sultan, Shahnaz, Vandvik, Per Olav, Sharma, Prateek, Rex, Douglas K, Foroutan, Farid, and Repici, Alessandro

Published
2024
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2. Impedance planimetry values for predicting clinical response following peroral endoscopic myotomy

Author

Moran, Robert A, Brewer Gutierrez, Olaya I, Rahden, Burkhard, Chang, Kenneth, Ujiki, Michael, Yoo, In Kyung, Gulati, Shraddha, Romanelli, John, Al-Nasser, Mohammed, Shimizu, Toshitaka, Hedberg, Mason H, Cho, Joo Young, Hayee, Bu, Desilets, David, Filser, Jörg, Fortinsky, Kyle, Haji, Amyn, Fayad, Lea, Sanaei, Omid, Dbouk, Mohamad, Kumbhari, Vivek, Wolf, Bethany J, Elmunzer, B Joseph, and Khashab, Mouen A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cohort Studies, Electric Impedance, Esophageal Achalasia, Esophageal Sphincter, Lower, Humans, Myotomy, Natural Orifice Endoscopic Surgery, Retrospective Studies, Treatment Outcome, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundThere is growing interest in developing impedance planimetry as a tool to enhance the clinical outcomes for endoscopic and surgical management of achalasia. The primary aim of this study was to determine whether impedance planimetry measurements can predict clinical response and reflux following peroral endoscopic myotomy (POEM).MethodsA multicenter cohort study of patients with achalasia undergoing POEM was established from prospective databases and retrospective chart reviews. Patients who underwent impedance planimetry before and after POEM were included. Clinical response was defined as an Eckardt score of ≤ 3. Tenfold cross-validated area under curve (AUC) values were established for the different impedance planimetry measurements associated with clinical response and reflux development.ResultsOf the 290 patients included, 91.7 % (266/290) had a clinical response and 39.4 % (108/274) developed reflux following POEM. The most predictive impedance planimetry measurements for a clinical response were: percent change in cross-sectional area (%ΔCSA) and percent change in distensibility index (%ΔDI), with AUCs of 0.75 and 0.73, respectively. Optimal cutoff values for %ΔCSA and %ΔDI to determine a clinical response were a change of 360 % and 272 %, respectively. Impedance planimetry values were much poorer at predicting post-POEM reflux, with AUCs ranging from 0.40 to 0.62.ConclusionPercent change in CSA and distensibility index were the most predictive measures of a clinical response, with a moderate predictive ability. Impedance planimetry values for predicting reflux following POEM showed weak predictive capacity.

Published
2021

4. Acute Diverticulitis

Author

Ortenzi, Monica, Williams, Sophie, Haji, Amyn, Ghiselli, Roberto, Guerrieri, Mario, Agresta, Ferdinando, editor, Podda, Mauro, editor, Campanile, Fabio Cesare, editor, Bergamini, Carlo, editor, and Anania, Gabriele, editor

Published
2021
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6. Computer-aided diagnosis for the resect-and-discard strategy for colorectal polyps: a systematic review and meta-analysis

Author

Hassan, Cesare, Rizkala, Tommy, Mori, Yuichi, Spadaccini, Marco, Misawa, Masashi, Antonelli, Giulio, Rondonotti, Emanuele, Dekker, Evelien, Houwen, Britt B S L, Pech, Oliver, Baumer, Sebastian, Li, James Weiquan, von Renteln, Daniel, Haumesser, Claire, Maselli, Roberta, Facciorusso, Antonio, Correale, Loredana, Menini, Maddalena, Schilirò, Alessandro, Khalaf, Kareem, Patel, Harsh, Radadiya, Dhruvil K, Bhandari, Pradeep, Kudo, Shin-ei, Sultan, Shahnaz, Vandvik, Per Olav, Sharma, Prateek, Rex, Douglas K, Foroutan, Farid, Repici, Alessandro, Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Massimi, Davide, Djinbachian, Roupen, Takishima, Kazumi, Mochizuki, Kenichi, Miyata, Yuki, Mochida, Kentaro, Akimoto, Yoshika, Kuroki, Takanori, Morita, Yuriko, Shiina, Osamu, Kato, Shun, Barua, Ishita, Holme, Øyvind, Wieszczy, Paulina, Løberg, Magnus, Kalager, Mette, Gulati, Shraddha, Williams, Sophie, Hayee, Bu, Patel, Mehul, Gunasingam, Nishmi, Kent, Alexandra, Emmanuel, Andrew, Haji, Amyn, Itoh, Hayato, Mori, Kensaku, Nemoto, Tetsuo, Munck, Carl, Aksel Nilsen, Jens, Astrup Hvattum, Stine, Oskar Frigstad, Svein, Tandberg, Petter, Lanza, Davide, and Bonanno, Giacomo

Abstract

The resect-and-discard strategy allows endoscopists to replace post-polypectomy pathology with real-time prediction of polyp histology during colonoscopy (optical diagnosis). We aimed to investigate the benefits and harms of implementing computer-aided diagnosis (CADx) for polyp pathology into the resect-and-discard strategy.

Published
2024
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8. The utilisation of high frequency mini probe colonoscopic ultrasound in the assessment of colorectal disease

Author

Haji, Amyn

Subjects
616.3
Abstract

This research looks at the feasibility of colonoscopic high frequency ultrasound in the colon using mini probe technology. The objectives are across four different areas with assessment of colonic cancer, malignant colorectal polyps, rectal polyps and diverticular disease. High frequency 12 and 20 MHz ultrasound were used to locally stage colonic cancer and compare this to conventional CT in patients undergoing elective colonic resection. In addition, depth of infiltration of rectal polyps was determined by 20 MHz ultrasound and these findings compared with MRI in patients undergoing TEMS procedure. Malignant colorectal polyps were assessed after endoscopic removal to assess for the presence of residual or recurrent disease in the colonic wall and also to stage the local lymph nodes. Finally, the thickness of colonic wall in patients with diverticular disease was measured using 20 MHz ultrasound and this was compared with normal controls. The research has clearly shown that colonoscopic high frequency mini probe ultrasound is feasible in the colon with reproducible results. Overall, 12 and 20 MHz colonoscopic ultrasound are superior to CT for local staging of colonic cancer. 20 MHz ultrasound offers greater accuracy for assessment of depth of infiltration of rectal polyps compared with MRI. This probe may also be utilised to assess the colonic wall for residual disease in the polypectomy scar of malignant polyps but larger numbers are needed with longer follow up in order to draw firm conclusions. Finally, it was feasible to measure the thickness of colonic wall in patients with diverticular disease and this was greater than that seen in normal patients. In conclusion, this research has been promising in that colonoscopic high frequency mini probe ultrasound is feasible in the colon and can be used to assess colorectal polyps and cancer and diverticular disease. In order to draw firm conclusions, this pilot research needs to be taken further with larger scale studies.

Published
2012

14. Efficacy and Safety of Peroral Endoscopic Myotomy for Treatment of Achalasia After Failed Heller Myotomy

Author

Ngamruengphong, Saowanee, Inoue, Haruhiro, Ujiki, Michael B., Patel, Lava Y., Bapaye, Amol, Desai, Pankaj N., Dorwat, Shivangi, Nakamura, Jun, Hata, Yoshitaka, Balassone, Valerio, Onimaru, Manabu, Ponchon, Thierry, Pioche, Mathieu, Roman, Sabine, Rivory, Jérôme, Mion, François, Garros, Aurélien, Draganov, Peter V., Perbtani, Yaseen, Abbas, Ali, Pannu, Davinderbir, Yang, Dennis, Perretta, Silvana, Romanelli, John, Desilets, David, Hayee, Bu, Haji, Amyn, Hajiyeva, Gulara, Ismail, Amr, Chen, Yen-I, Bukhari, Majidah, Haito-Chavez, Yamile, Kumbhari, Vivek, Saxena, Payal, Talbot, Michael, Chiu, Philip Wai-yan, Yip, Hon-Chi, Wong, Vivien Wai-Yin, Hernaez, Ruben, Maselli, Roberta, Repici, Alessandro, and Khashab, Mouen A.

Published
2017
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20. Endoscopic suturing for GI applications: initial results from a prospective multicenter European registry

Author

Maselli, Roberta, primary, Palma, Rossella, additional, Traina, Mario, additional, Granata, Antonino, additional, Juzgado, Diego, additional, Bisello, Marco, additional, Neuhaus, Horst, additional, Beyna, Torsten, additional, Bansi, Davinder, additional, Flor, Laura, additional, Bhandari, Pradeep, additional, Abdelrahim, Mo, additional, Haji, Amyn, additional, Haidry, Rehan, additional, and Repici, Alessandro, additional

Published
2022
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28. ARTIFICIAL INTELLIGENCE FOR REAL-TIME OPTICAL DIAGNOSIS OF NEOPLASTIC POLYPS DURING COLONOSCOPY

Author

Barua, Ishita, primary, Wieszczy, Paulina, additional, Kudo, Shinei, additional, Misawa, Masashi, additional, Holme, Oeyvind, additional, Gulati, Shraddha, additional, Williams, Sophie, additional, Mori, Kensaku, additional, Itoh, Hayato, additional, Takishima, Kazumi, additional, Mochizuki, Kenichi, additional, Miyata, Yuki, additional, Mochida, Kentaro, additional, Akimoto, Yoshika, additional, Kuroki, Takanori, additional, Morita, Yuriko, additional, Shiina, Osamu, additional, Kato, Shun, additional, Nemoto, Tetsuo, additional, Hayee, Bu, additional, Patel, Mehul, additional, Gunasingam, Nishmi, additional, Kent, Alexandra J., additional, Emmanuel, Andrew, additional, Munck, Carl, additional, Nilsen, Jens Aksel, additional, Hvattum, Stine Astrup, additional, Frigstad, Svein Oskar, additional, Tandberg, Petter, additional, Løberg, Magnus, additional, Kalager, Mette, additional, Haji, Amyn, additional, Bretthauer, Michael, additional, and Mori, Yuichi, additional

Published
2022
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29. P282 Artificial intelligence for real-time optical diagnosis of neoplastic polyps during colonoscopy

Author

Barua, Ishita, primary, Wieszczy, Paulina, additional, Kudo, Shin-ei, additional, Misawa, Masashi, additional, Holme, Øyvind, additional, Gulati, Shraddha, additional, Williams, Sophie, additional, Mori, Kensaku, additional, Itoh, Hayato, additional, Takishima, Kazumi, additional, Mochizuki, Kenichi, additional, Miyata, Yuki, additional, Mochida, Kentaro, additional, Akimoto, Yoshika, additional, Kuroki, Takanori, additional, Morita, Yuriko, additional, Shiina, Osamu, additional, Kato, Shun, additional, Nemoto, Tetsuo, additional, Hayee, Bu, additional, Mehul, Patel, additional, Gunasingam, Nishmi, additional, Kent, Alexandra, additional, Emmanuel, Andrew, additional, Munck, Carl, additional, Nilsen, Jens, additional, Hvattum, Stine, additional, Frigstad, Svein, additional, Tandberg, Petter, additional, Løberg, Magnus, additional, Kalager, Mette, additional, Haji, Amyn, additional, Bretthauer, Michael, additional, and Mori, Yuichi, additional

Published
2022
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32. Real-Time Artificial Intelligence–Based Optical Diagnosis of Neoplastic Polyps during Colonoscopy

Author

Barua, Ishita, primary, Wieszczy, Paulina, additional, Kudo, Shin-ei, additional, Misawa, Masashi, additional, Holme, Øyvind, additional, Gulati, Shraddha, additional, Williams, Sophie, additional, Mori, Kensaku, additional, Itoh, Hayato, additional, Takishima, Kazumi, additional, Mochizuki, Kenichi, additional, Miyata, Yuki, additional, Mochida, Kentaro, additional, Akimoto, Yoshika, additional, Kuroki, Takanori, additional, Morita, Yuriko, additional, Shiina, Osamu, additional, Kato, Shun, additional, Nemoto, Tetsuo, additional, Hayee, Bu, additional, Patel, Mehul, additional, Gunasingam, Nishmi, additional, Kent, Alexandra, additional, Emmanuel, Andrew, additional, Munck, Carl, additional, Nilsen, Jens Aksel, additional, Hvattum, Stine Astrup, additional, Frigstad, Svein Oskar, additional, Tandberg, Petter, additional, Løberg, Magnus, additional, Kalager, Mette, additional, Haji, Amyn, additional, Bretthauer, Michael, additional, and Mori, Yuichi, additional

Published
2022
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35. Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial

Author

Mingrone, Geltrude, Baar, Annieke C.G. van, Hopkins, David, Moura, Eduardo G.H. de, Cercato, Cintia, Rajagopalan, Harith, Lopez-Talavera, Juan Carlos, White, Kelly, Bhambhani, Vijeta, Costamagna, Guido, Haidry, Rehan, Grecco, Eduardo, Aithal, Guruprasad P, Repici, Alessandro, Hayee, Bu, Haji, Amyn, Morris, A John, Bisschops, Raf, Chouhan, Manil D., Sakai, Naomi S., Bhatt, Deepak L., Sanyal, Arun J., and Bergman, Jacques J.G.H.M.

Subjects
embryonic structures, Duodenal mucosal resurfacing, DMR, endoscopic procedure, non-alcoholic fatty liver disease, NAFLD, type 2 diabetes, T2D, Revita system
Abstract

Objective: Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority RCT, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR [catheter and system], on glycaemic control and liver fat content in Type 2 Diabetes (T2D).Design: Eligible patients (HbA1c 59–86mmol/mol, BMI ≥24 and ≤40kg/m2, fasting insulin >48.6pmol/L, ≥1 oral antidiabetic medication) enrolled in Europe and Brazil. Primary endpoints were safety, change from baseline in HbA1c at 24 weeks, and liver magnetic resonance imaging proton-density fat fraction (MRI-PDFF) at 12 weeks. Results: Overall mITT (DMR N=56; sham N=52), 24-weeks post-DMR, median (IQR) HbA1c change was −10.4 (18.6) mmol/mol in DMR group versus −7.1 (16.4) mmol/mol in sham group (p=0.147). In patients with baseline liver MRI-PDFF >5% (DMR n=48; sham n=43), 12-week post-DMR liver-fat change was −5.4 (5.6)% in DMR group versus −2.9 (6.2)% in sham group (p=0.096). Results from prespecified interaction testing and clinical parameter assessment showed heterogeneity between European (DMR N=39; sham N=37) and Brazilian (DMR N=17; sham N=16) populations (p=0.063), therefore, results were stratified by region. In European mITT, 24-weeks post-DMR, median (IQR) HbA1c change was –6.6 mmol/mol (17.5 mmol/mol) versus –3.3 mmol/mol (10.9 mmol/mol) post-sham (p=0.033); 12-week post-DMR liver-fat change was –5.4% (6.1%) versus –2.2% (4.3%) post-sham (p=0.035). Brazilian mITT results trended towards DMR benefit in HbA1c, but not liver fat, in context of a large sham effect. In overall PP, patients with high baseline fasting plasma glucose ([FPG] ≥10 mmol/L) had significantly greater reductions in HbA1c post-DMR versus sham (p=0.002). Most adverse events were mild and transient. Conclusions: DMR is safe and exerts beneficial disease-modifying metabolic effects in T2D with or without non-alcoholic liver disease (NAFLD), particularly in patients with high FPG.

Published
2022

42. ENVIRONMENTAL IMPACT OF OPTICAL DIAGNOSIS BY ARTIFICIAL INTELLIGENCE IN COLONOSCOPY: A PROSPECTIVE TRIAL.

Author

Olabintan, Olaolu, Halvorsen, Natalie, Baddeley, Robin, Kudo, Shin-ei, Barua, Ishita, Misawa, Masashi, Wieszczy, Paulina, Mori, Kensaku, Nilsen, Jens Aksel, Frigstad, Svein Oskar, East, James, Rastogi, Amit, Hassan, Cesare, Kalager, Mette, Løberg, Magnus, Haji, Amyn, holme, Øyvind, Bretthauer, Michael, Hayee, Bu'Hussain, and Mori, Yuichi

Published
2024
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43. Clinical outcome of non-curative endoscopic submucosal dissection for early colorectal cancer

Author

Spadaccini, Marco, primary, Bourke, Michael J, additional, Maselli, Roberta, additional, Pioche, Marhieu, additional, Bhandari, Pradeep, additional, Jacques, Jérémie, additional, Haji, Amyn, additional, Yang, Dennis, additional, Albéniz, Eduardo, additional, Kaminski, Michal Filip, additional, Messmann, Helmut, additional, Herreros de Tejada, Alberto, additional, Sferrazza, Sandro, additional, Pekarek, Boris, additional, Rivory, Jerome, additional, Geyl, Sophie, additional, Gulati, Shraddha, additional, Draganov, Peter, additional, Shahidi, Neal, additional, Hossain, Ejaz, additional, Fleischmann, Carola, additional, Vespa, Edoardo, additional, Iannone, Andrea, additional, Alkandari, Asma, additional, Hassan, Cesare, additional, and Repici, Alessandro, additional

Published
2022
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44. Near-focus narrow-band imaging classification of villous atrophy in suspected celiac disease: development and international validation

Author

Gulati, Shraddha, primary, Emmanuel, Andrew, additional, Ong, Mark, additional, Pavlidis, Polychronis, additional, Patel, Mehul, additional, El-Menabawey, Tareq, additional, Vackova, Zuzana, additional, Dubois, Patrick, additional, Murino, Alberto, additional, Martinek, Jan, additional, Sethi, Amrita, additional, Neumann, Helmut, additional, Haji, Amyn, additional, and Hayee, Bu’Hussain, additional

Published
2021
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45. Nodal metastases in small rectal neuroendocrine tumours

Author

O’Neill, Sarah, primary, Haji, Amyn, additional, Ryan, Suzanne, additional, Clement, Dominique, additional, Sarras, Konstantinos, additional, Hayee, Bu, additional, Mulholland, Nicola, additional, Ramage, John K., additional, and Srirajaskanthan, Rajaventhan, additional

Published
2021
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50. Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: The randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial

Author

Mingrone, Geltrude, van Baar, Annieke A.C., Devière, Jacques, Hopkins, David, Moura, Eduardo, Cercato, Cintia, Rajagopalan, Harith, Lopez-Talavera, Juan Carlos, White, Kelly, Bhambhani, Vijeta, Costamagna, Guido, Haidry, Rehan R.J., Grecco, Eduardo, Galvao Neto, Manoel M.P., Aithal, Guruprasad P, Repici, Alessandro, Hayee, Bu'Hussain, Haji, Amyn, Morris, Allan John, Bisschops, Raf, Chouhan, Manil M.D., Sakai, Naomi N.S., Bhatt, Deepak D.L., Sanyal, Arun Jayant, Bergman, Jacques J.J.G.H.M., Mingrone, Geltrude, van Baar, Annieke A.C., Devière, Jacques, Hopkins, David, Moura, Eduardo, Cercato, Cintia, Rajagopalan, Harith, Lopez-Talavera, Juan Carlos, White, Kelly, Bhambhani, Vijeta, Costamagna, Guido, Haidry, Rehan R.J., Grecco, Eduardo, Galvao Neto, Manoel M.P., Aithal, Guruprasad P, Repici, Alessandro, Hayee, Bu'Hussain, Haji, Amyn, Morris, Allan John, Bisschops, Raf, Chouhan, Manil M.D., Sakai, Naomi N.S., Bhatt, Deepak D.L., Sanyal, Arun Jayant, and Bergman, Jacques J.J.G.H.M.

Abstract

Objective: Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR (catheter and system)), on glycaemic control and liver fat content in type 2 diabetes (T2D). Design: Eligible patients (haemoglobin A1c (HbA1c) 59-86 mmol/mol, body mass index≥24 and ≤40 kg/m2, fasting insulin >48.6 pmol/L, ≥1 oral antidiabetic medication) enrolled in Europe and Brazil. Primary endpoints were safety, change from baseline in HbA1c at 24 weeks, and liver MRI proton-density fat fraction (MRI-PDFF) at 12 weeks. Results: Overall mITT (DMR n=56; sham n=52), 24 weeks post DMR, median (IQR) HbA1c change was -10.4 (18.6) mmol/mol in DMR group versus -7.1 (16.4) mmol/mol in sham group (p=0.147). In patients with baseline liver MRI-PDFF >5% (DMR n=48; sham n=43), 12-week post-DMR liver-fat change was -5.4 (5.6)% in DMR group versus -2.9 (6.2)% in sham group (p=0.096). Results from prespecified interaction testing and clinical parameter assessment showed heterogeneity between European (DMR n=39; sham n=37) and Brazilian (DMR n=17; sham n=16) populations (p=0.063); therefore, results were stratified by region. In European mITT, 24 weeks post DMR, median (IQR) HbA1c change was -6.6 mmol/mol (17.5 mmol/mol) versus -3.3 mmol/mol (10.9 mmol/mol) post-sham (p=0.033); 12-week post-DMR liver-fat change was -5.4% (6.1%) versus -2.2% (4.3%) post-sham (p=0.035). Brazilian mITT results trended towards DMR benefit in HbA1c, but not liver fat, in context of a large sham effect. In overall PP, patients with high baseline fasting plasma glucose ((FPG)≥10 mmol/L) had significantly greater reductions in HbA1c post-DMR versus sham (p=0.002). Most adverse events were mild and transient. Conclusions: DMR is safe and exerts beneficial disease-modifying metabolic effects in T2D with or without non-alcoholic liver disease, part, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

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