7 results on '"Hajek, T. (Tomas)"'
Search Results
2. Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
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Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), Andreassen, O.A. (Ole), Manchia, M. (Mriko), Vieta, E. (Eduard), Smeland, O.B. (Olav B.), Altimus, C. (Cara), Bechdolf, A. (Andreas), Bellivier, F. (Frank), Bergink, V. (Veerle), Fagiolini, A. (Andrea), Geddes, J.R. (John R.), Hajek, T. (Tomas), Henry, C. (C.), Kupka, R.W. (Ralph ), Lagerberg, T.V. (Trine V.), Licht, R.W. (Rasmus W.), Martinez-Cengotitabengoa, M. (Monica), Morken, G. (Gunnar), Nielsen, R.E. (René E.), Pinto, A.G. (Ana Gonzalez), Reif, A. (Andreas), Rietschel, M. (Marcella), Ritter, P. (Phillip), Schulze, T.G. (Thomas G.), Scott, J. (Jan), Severus, E. (Emanuel), Yildiz, A. (Aysegul), Kessing, L.V. (Lars Vedel), Bauer, M. (Michael), Goodwin, G.M. (Guy M.), and Andreassen, O.A. (Ole)
- Abstract
Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemin
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- 2020
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3. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
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Ching, C.R.K. (Christopher), Hibar, D.P. (Derrek P.), Gurholt, T.P. (Tiril P.), Nunes, A. (Abraham), Thomopoulos, S.I. (Sophia I.), Abé, C. (Christoph), Agartz, I. (Ingrid), Brouwer, R.M. (Rachel), Cannon, D.M. (Dara), de Zwarte, S.M.C. (Sonja M. C.), Eyler, L.T. (Lisa T.), Favre, P. (Pauline), Hajek, T. (Tomas), Haukvik, U.K. (Unn), Houenou, J. (Josselin), Landén, M. (Mikael), Lett, T.A. (Tristram A.), McDonald, C. (Colm), Nabulsi, L. (Leila), Patel, Y. (Yash), Pauling, M.E. (Melissa E.), Paus, T. (Tomas), Radua, J. (Joaquim), Soeiro-de-Souza, M.G. (Marcio G.), Tronchin, G. (Giulia), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Walter, H.J. (Henrik), Zeng, L.-L. (Ling-Li), Alda, M. (Martin), Almeida, J. (Jorge), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Altimus, C. (Cara), Bauer, M. (Michael), Baune, B.T., Bearden, C.E. (Carrie), Bellani, M. (Marcella), Benedetti, F. (Francesco), Berk, M. (Michael), Bilderbeck, A.C. (Amy C.), Blumberg, H.P. (Hilary P.), Bøen, E. (Erlend), Bollettini, I. (Irene), del Mar Bonnin, C. (Caterina), Brambilla, P. (Paolo), Canales-Rodríguez, E.J. (Erick J.), Caseras, X. (Xavier), Dandash, O. (Orwa), Dannlowski, U. (Udo), Delvecchio, G. (Giuseppe), Díaz-Zuluaga, A.M. (Ana M.), Dima, D. (Danai), Duchesnay, É. (Édouard), Elvsåshagen, T. (Torbjørn), Fears, S. (Scott), Frangou, S. (Sophia), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Green, M.J. (Melissa J.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Haarman, B.C.M. (Benno), Henry, C. (C.), Howells, F.M. (Fleur M.), Ives-Deliperi, V. (Victoria), Jansen, A. (Andreas), Kircher, T.T.J. (Tilo T. J.), Knöchel, C. (Christian), Kramer, B. (Bernd), Lafer, B. (Beny), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), MacIntosh, B.J. (Bradley J), Melloni, E.M.T. (Elisa M. T.), Mitchell, P.B. (Philip B.), Nenadic, I. (Igor), Nery, F. (Fabiano), Nugent, A.C. (Allison), Oertel, V. (Viola), Ophoff, R.A. (Roel), Ota, M. (Miho), Overs, B.J. (Bronwyn J.), Pham, D.L. (Daniel L.), Phillips, M.L. (Mary L.), Pineda-Zapata, J.A. (Julian A.), Poletti, S. (Sara), Polosan, M. (Mircea), Pomarol-Clotet, E. (Edith), Pouchon, A. (Arnaud), Quidé, Y. (Yann), Rive, M.M. (Maria M.), Roberts, G. (Gloria), Ruhé, H.G. (Henricus G.Eric), Salvador, R. (Raymond), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Schene, A.H. (Aart), Sim, K. (Kang), Soares, J.C. (Jair C.), Stäblein, M. (Michael), Stein, D.J. (Dan J.), Tamnes, C.K. (Christian K.), Thomaidis, G.V. (Georgios V.), Upegui, C.V. (Cristian Vargas), Veltman, D.J. (Dick), Wessa, M. (Michèle), Westlye, L.T. (Lars), Whalley, H.C. (Heather C.), Wolf, D.H. (Daniel H.), Wu, M.-J. (Mon-Ju), Yatham, L.N. (Lakshmi N.), Zarate, C.A. (Carlos A.), Thompson, P.M. (Paul), Andreassen, O.A. (Ole), Ching, C.R.K. (Christopher), Hibar, D.P. (Derrek P.), Gurholt, T.P. (Tiril P.), Nunes, A. (Abraham), Thomopoulos, S.I. (Sophia I.), Abé, C. (Christoph), Agartz, I. (Ingrid), Brouwer, R.M. (Rachel), Cannon, D.M. (Dara), de Zwarte, S.M.C. (Sonja M. C.), Eyler, L.T. (Lisa T.), Favre, P. (Pauline), Hajek, T. (Tomas), Haukvik, U.K. (Unn), Houenou, J. (Josselin), Landén, M. (Mikael), Lett, T.A. (Tristram A.), McDonald, C. (Colm), Nabulsi, L. (Leila), Patel, Y. (Yash), Pauling, M.E. (Melissa E.), Paus, T. (Tomas), Radua, J. (Joaquim), Soeiro-de-Souza, M.G. (Marcio G.), Tronchin, G. (Giulia), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Walter, H.J. (Henrik), Zeng, L.-L. (Ling-Li), Alda, M. (Martin), Almeida, J. (Jorge), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Altimus, C. (Cara), Bauer, M. (Michael), Baune, B.T., Bearden, C.E. (Carrie), Bellani, M. (Marcella), Benedetti, F. (Francesco), Berk, M. (Michael), Bilderbeck, A.C. (Amy C.), Blumberg, H.P. (Hilary P.), Bøen, E. (Erlend), Bollettini, I. (Irene), del Mar Bonnin, C. (Caterina), Brambilla, P. (Paolo), Canales-Rodríguez, E.J. (Erick J.), Caseras, X. (Xavier), Dandash, O. (Orwa), Dannlowski, U. (Udo), Delvecchio, G. (Giuseppe), Díaz-Zuluaga, A.M. (Ana M.), Dima, D. (Danai), Duchesnay, É. (Édouard), Elvsåshagen, T. (Torbjørn), Fears, S. (Scott), Frangou, S. (Sophia), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Green, M.J. (Melissa J.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Haarman, B.C.M. (Benno), Henry, C. (C.), Howells, F.M. (Fleur M.), Ives-Deliperi, V. (Victoria), Jansen, A. (Andreas), Kircher, T.T.J. (Tilo T. J.), Knöchel, C. (Christian), Kramer, B. (Bernd), Lafer, B. (Beny), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), MacIntosh, B.J. (Bradley J), Melloni, E.M.T. (Elisa M. T.), Mitchell, P.B. (Philip B.), Nenadic, I. (Igor), Nery, F. (Fabiano), Nugent, A.C. (Allison), Oertel, V. (Viola), Ophoff, R.A. (Roel), Ota, M. (Miho), Overs, B.J. (Bronwyn J.), Pham, D.L. (Daniel L.), Phillips, M.L. (Mary L.), Pineda-Zapata, J.A. (Julian A.), Poletti, S. (Sara), Polosan, M. (Mircea), Pomarol-Clotet, E. (Edith), Pouchon, A. (Arnaud), Quidé, Y. (Yann), Rive, M.M. (Maria M.), Roberts, G. (Gloria), Ruhé, H.G. (Henricus G.Eric), Salvador, R. (Raymond), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Schene, A.H. (Aart), Sim, K. (Kang), Soares, J.C. (Jair C.), Stäblein, M. (Michael), Stein, D.J. (Dan J.), Tamnes, C.K. (Christian K.), Thomaidis, G.V. (Georgios V.), Upegui, C.V. (Cristian Vargas), Veltman, D.J. (Dick), Wessa, M. (Michèle), Westlye, L.T. (Lars), Whalley, H.C. (Heather C.), Wolf, D.H. (Daniel H.), Wu, M.-J. (Mon-Ju), Yatham, L.N. (Lakshmi N.), Zarate, C.A. (Carlos A.), Thompson, P.M. (Paul), and Andreassen, O.A. (Ole)
- Abstract
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studi
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- 2020
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4. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
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Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), Zelman, V. (Vladimir), Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), and Zelman, V. (Vladimir)
- Abstract
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.
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- 2020
- Full Text
- View/download PDF
5. Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
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Nunes, A. (Abraham), Schnack, H. (Hugo), Ching, C.R.K. (Christopher), Agartz, I. (Ingrid), Akudjedu, T.N. (Theophilus N.), Alda, M. (Martin), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Bauer, J. (Jochen), Baune, B.T., Bøen, E. (Erlend), Bonnin, C.M. (Caterina del Mar), Busatto, G.F. (Geraldo F.), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara), Caseras, X. (Xavier), Chaim-Avancini, T.M. (Tiffany M.), Dannlowski, U. (Udo), Díaz-Zuluaga, A.M. (Ana M.), Dietsche, B. (Bruno), Doan, N.T. (Nhat Trung), Duchesnay, E. (Edouard), Elvsåshagen, T. (Torbjørn), Emden, D. (Daniel), Eyler, L.T. (Lisa T.), Fatjó-Vilas, M. (Mar), Favre, P. (Pauline), Foley, S.F. (Sonya F.), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Grotegerd, D. (Dominik), Hahn, T. (Tim), Henry, C. (C.), Hibar, D.P. (Derrek P.), Houenou, J. (Josselin), Howells, F.M. (Fleur M.), Jahanshad, N. (Neda), Kaufmann, T. (Tobias), Kenney, J. (Joanne), Kircher, T.T.J. (Tilo T. J.), Krug, A. (Axel), Lagerberg, T.V. (Trine V.), Lenroot, R.K. (Rhoshel), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), Malt, U.F. (Ulrik), McDonald, C. (Colm), Mitchell, P.B. (Philip B.), Mwangi, B. (Benson), Nabulsi, L. (Leila), Opel, N. (Nils), Overs, B.J. (Bronwyn J.), Pineda-Zapata, J.A. (Julian A.), Pomarol-Clotet, E. (Edith), Redlich, R. (Ronny), Roberts, G. (Gloria), Rosa, P.G. (Pedro G.), Salvador, R. (Raymond), Satterthwaite, T.D. (Theodore), Soares, J.C. (Jair C.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Trappenberg, T. (Thomas), Uhlmann, A. (Anne), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Westlye, L.T. (Lars), Wolf, D.H. (Daniel H.), Yüksel, D. (Dilara), Zanetti, M.V. (Marcus V.), Andreassen, O.A. (Ole), Thompson, P.M. (Paul), Hajek, T. (Tomas), Nunes, A. (Abraham), Schnack, H. (Hugo), Ching, C.R.K. (Christopher), Agartz, I. (Ingrid), Akudjedu, T.N. (Theophilus N.), Alda, M. (Martin), Alnæs, D. (Dag), Alonso-Lana, S. (Silvia), Bauer, J. (Jochen), Baune, B.T., Bøen, E. (Erlend), Bonnin, C.M. (Caterina del Mar), Busatto, G.F. (Geraldo F.), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara), Caseras, X. (Xavier), Chaim-Avancini, T.M. (Tiffany M.), Dannlowski, U. (Udo), Díaz-Zuluaga, A.M. (Ana M.), Dietsche, B. (Bruno), Doan, N.T. (Nhat Trung), Duchesnay, E. (Edouard), Elvsåshagen, T. (Torbjørn), Emden, D. (Daniel), Eyler, L.T. (Lisa T.), Fatjó-Vilas, M. (Mar), Favre, P. (Pauline), Foley, S.F. (Sonya F.), Fullerton, J.M. (Janice M.), Glahn, D.C. (David), Goikolea, J.M. (Jose M.), Grotegerd, D. (Dominik), Hahn, T. (Tim), Henry, C. (C.), Hibar, D.P. (Derrek P.), Houenou, J. (Josselin), Howells, F.M. (Fleur M.), Jahanshad, N. (Neda), Kaufmann, T. (Tobias), Kenney, J. (Joanne), Kircher, T.T.J. (Tilo T. J.), Krug, A. (Axel), Lagerberg, T.V. (Trine V.), Lenroot, R.K. (Rhoshel), López-Jaramillo, C. (Carlos), Machado-Vieira, R. (Rodrigo), Malt, U.F. (Ulrik), McDonald, C. (Colm), Mitchell, P.B. (Philip B.), Mwangi, B. (Benson), Nabulsi, L. (Leila), Opel, N. (Nils), Overs, B.J. (Bronwyn J.), Pineda-Zapata, J.A. (Julian A.), Pomarol-Clotet, E. (Edith), Redlich, R. (Ronny), Roberts, G. (Gloria), Rosa, P.G. (Pedro G.), Salvador, R. (Raymond), Satterthwaite, T.D. (Theodore), Soares, J.C. (Jair C.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Trappenberg, T. (Thomas), Uhlmann, A. (Anne), van Haren, N.E.M. (Neeltje E. M.), Vieta, E. (Eduard), Westlye, L.T. (Lars), Wolf, D.H. (Daniel H.), Yüksel, D. (Dilara), Zanetti, M.V. (Marcus V.), Andreassen, O.A. (Ole), Thompson, P.M. (Paul), and Hajek, T. (Tomas)
- Abstract
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal application of ML requires large, multi-site datasets. We applied ML (support vector machines) to MRI data (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control participants from 13 cohorts in the ENIGMA consortium. We attempted to differentiate BD from control participants, investigated different data handling strategies and studied the neuroimaging/clinical features most important for classification. Individual site accuracies ranged from 45.23% to 81.07%. Aggregate subject-level analyses yielded the highest accuracy (65.23%, 95% CI = 63.47–67.00, ROC-AUC = 71.49%, 95% CI = 69.39–73.59), followed by leave-one-site-out cross-validation (accuracy = 58.67%, 95% CI = 56.70–60.63). Meta-analysis of individual site accuracies did not provide above chance results. There was substantial agreement between the regions that contributed to identification of BD participants in the best performing site and in the aggregate dataset (Cohen’s Kappa = 0.83, 95% CI = 0.829–0.831). Treatment with anticonvulsants and age were associated with greater odds of correct classification. Although short of the 80% clinically relevant accuracy threshold, the resul
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- 2018
- Full Text
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6. Tundra Trait Team:a database of plant traits spanning the tundra biome
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Bjorkman, A. D. (Anne D.), Myers-Smith, I. H. (Isla H.), Elmendorf, S. C. (Sarah C.), Normand, S. (Signe), Thomas, H. J. (Haydn J. D.), Alatalo, J. M. (Juha M.), Alexander, H. (Heather), Anadon-Rosell, A. (Alba), Angers-Blondin, S. (Sandra), Bai, Y. (Yang), Baruah, G. (Gaurav), te Beest, M. (Mariska), Berner, L. (Logan), Bjork, R. G. (Robert G.), Blok, D. (Daan), Bruelheide, H. (Helge), Buchwal, A. (Agata), Buras, A. (Allan), Carbognani, M. (Michele), Christie, K. (Katherine), Collier, L. S. (Laura S.), Cooper, E. J. (Elisabeth J.), Cornelissen, J. H. (J. Hans C.), Dickinson, K. J. (Katharine J. M.), Dullinger, S. (Stefan), Elberling, B. (Bo), Eskelinen, A. (Anu), Forbes, B. C. (Bruce C.), Frei, E. R. (Esther R.), Iturrate-Garcia, M. (Maitane), Good, M. K. (Megan K.), Grau, O. (Oriol), Green, P. (Peter), Greve, M. (Michelle), Grogan, P. (Paul), Haider, S. (Sylvia), Hajek, T. (Tomas), Hallinger, M. (Martin), Happonen, K. (Konsta), Harper, K. A. (Karen A.), Heijmans, M. M. (Monique M. P. D.), Henry, G. H. (Gregory H. R.), Hermanutz, L. (Luise), Hewitt, R. E. (Rebecca E.), Hollister, R. D. (Robert D.), Hudson, J. (James), Huelber, K. (Karl), Iversen, C. M. (Colleen M.), Jaroszynska, F. (Francesca), Jimenez-Alfaro, B. (Borja), Johnstone, J. (Jill), Jorgensen, R. H. (Rasmus Halfdan), Kaarlejarvi, E. (Elina), Klady, R. (Rebecca), Klimesova, J. (Jitka), Korsten, A. (Annika), Kuleza, S. (Sara), Kulonen, A. (Aino), Lamarque, L. J. (Laurent J.), Lantz, T. (Trevor), Lavalle, A. (Amanda), Lembrechts, J. J. (Jonas J.), Levesque, E. (Esther), Little, C. J. (Chelsea J.), Luoto, M. (Miska), Macek, P. (Petr), Mack, M. C. (Michelle C.), Mathakutha, R. (Rabia), Michelsen, A. (Anders), Milbau, A. (Ann), Molau, U. (Ulf), Morgan, J. W. (John W.), Morsdorf, M. A. (Martin Alfons), Nabe-Nielsen, J. (Jacob), Nielsen, S. S. (Sigrid Scholer), Ninot, J. M. (Josep M.), Oberbauer, S. F. (Steven F.), Olofsson, J. (Johan), Onipchenko, V. G. (Vladimir G.), Petraglia, A. (Alessandro), Pickering, C. (Catherine), Prevey, J. S. (Janet S.), Rixen, C. (Christian), Rumpf, S. B. (Sabine B.), Schaepman-Strub, G. (Gabriela), Semenchuk, P. (Philipp), Shetti, R. (Rohan), Soudzilovskaia, N. A. (Nadejda A.), Spasojevic, M. J. (Marko J.), Speed, J. D. (James David Mervyn), Street, L. E. (Lorna E.), Suding, K. (Katharine), Tape, K. D. (Ken D.), Tomaselli, M. (Marcello), Trant, A. (Andrew), Treier, U. A. (Urs A.), Tremblay, J.-P. (Jean-Pierre), Tremblay, M. (Maxime), Venn, S. (Susanna), Virkkala, A.-M. (Anna-Maria), Vowles, T. (Tage), Weijers, S. (Stef), Wilmking, M. (Martin), Wipf, S. (Sonja), Zamin, T. (Tara), Bjorkman, A. D. (Anne D.), Myers-Smith, I. H. (Isla H.), Elmendorf, S. C. (Sarah C.), Normand, S. (Signe), Thomas, H. J. (Haydn J. D.), Alatalo, J. M. (Juha M.), Alexander, H. (Heather), Anadon-Rosell, A. (Alba), Angers-Blondin, S. (Sandra), Bai, Y. (Yang), Baruah, G. (Gaurav), te Beest, M. (Mariska), Berner, L. (Logan), Bjork, R. G. (Robert G.), Blok, D. (Daan), Bruelheide, H. (Helge), Buchwal, A. (Agata), Buras, A. (Allan), Carbognani, M. (Michele), Christie, K. (Katherine), Collier, L. S. (Laura S.), Cooper, E. J. (Elisabeth J.), Cornelissen, J. H. (J. Hans C.), Dickinson, K. J. (Katharine J. M.), Dullinger, S. (Stefan), Elberling, B. (Bo), Eskelinen, A. (Anu), Forbes, B. C. (Bruce C.), Frei, E. R. (Esther R.), Iturrate-Garcia, M. (Maitane), Good, M. K. (Megan K.), Grau, O. (Oriol), Green, P. (Peter), Greve, M. (Michelle), Grogan, P. (Paul), Haider, S. (Sylvia), Hajek, T. (Tomas), Hallinger, M. (Martin), Happonen, K. (Konsta), Harper, K. A. (Karen A.), Heijmans, M. M. (Monique M. P. D.), Henry, G. H. (Gregory H. R.), Hermanutz, L. (Luise), Hewitt, R. E. (Rebecca E.), Hollister, R. D. (Robert D.), Hudson, J. (James), Huelber, K. (Karl), Iversen, C. M. (Colleen M.), Jaroszynska, F. (Francesca), Jimenez-Alfaro, B. (Borja), Johnstone, J. (Jill), Jorgensen, R. H. (Rasmus Halfdan), Kaarlejarvi, E. (Elina), Klady, R. (Rebecca), Klimesova, J. (Jitka), Korsten, A. (Annika), Kuleza, S. (Sara), Kulonen, A. (Aino), Lamarque, L. J. (Laurent J.), Lantz, T. (Trevor), Lavalle, A. (Amanda), Lembrechts, J. J. (Jonas J.), Levesque, E. (Esther), Little, C. J. (Chelsea J.), Luoto, M. (Miska), Macek, P. (Petr), Mack, M. C. (Michelle C.), Mathakutha, R. (Rabia), Michelsen, A. (Anders), Milbau, A. (Ann), Molau, U. (Ulf), Morgan, J. W. (John W.), Morsdorf, M. A. (Martin Alfons), Nabe-Nielsen, J. (Jacob), Nielsen, S. S. (Sigrid Scholer), Ninot, J. M. (Josep M.), Oberbauer, S. F. (Steven F.), Olofsson, J. (Johan), Onipchenko, V. G. (Vladimir G.), Petraglia, A. (Alessandro), Pickering, C. (Catherine), Prevey, J. S. (Janet S.), Rixen, C. (Christian), Rumpf, S. B. (Sabine B.), Schaepman-Strub, G. (Gabriela), Semenchuk, P. (Philipp), Shetti, R. (Rohan), Soudzilovskaia, N. A. (Nadejda A.), Spasojevic, M. J. (Marko J.), Speed, J. D. (James David Mervyn), Street, L. E. (Lorna E.), Suding, K. (Katharine), Tape, K. D. (Ken D.), Tomaselli, M. (Marcello), Trant, A. (Andrew), Treier, U. A. (Urs A.), Tremblay, J.-P. (Jean-Pierre), Tremblay, M. (Maxime), Venn, S. (Susanna), Virkkala, A.-M. (Anna-Maria), Vowles, T. (Tage), Weijers, S. (Stef), Wilmking, M. (Martin), Wipf, S. (Sonja), and Zamin, T. (Tara)
- Abstract
Motivation: The Tundra Trait Team (TTT) database includes field‐based measurements of key traits related to plant form and function at multiple sites across the tundra biome. This dataset can be used to address theoretical questions about plant strategy and trade‐offs, trait–environment relationships and environmental filtering, and trait variation across spatial scales, to validate satellite data, and to inform Earth system model parameters. Main types of variable contained: The database contains 91,970 measurements of 18 plant traits. The most frequently measured traits (> 1,000 observations each) include plant height, leaf area, specific leaf area, leaf fresh and dry mass, leaf dry matter content, leaf nitrogen, carbon and phosphorus content, leaf C:N and N:P, seed mass, and stem specific density. Spatial location and grain: Measurements were collected in tundra habitats in both the Northern and Southern Hemispheres, including Arctic sites in Alaska, Canada, Greenland, Fennoscandia and Siberia, alpine sites in the European Alps, Colorado Rockies, Caucasus, Ural Mountains, Pyrenees, Australian Alps, and Central Otago Mountains (New Zealand), and sub‐Antarctic Marion Island. More than 99% of observations are georeferenced. Time period and grain: All data were collected between 1964 and 2018. A small number of sites have repeated trait measurements at two or more time periods. Major taxa and level of measurement: Trait measurements were made on 978 terrestrial vascular plant species growing in tundra habitats. Most observations are on individuals (86%), while the remainder represent plot or site means or maximums per species. Software format: csv file and GitHub repository with data cleaning scripts in R; contribution to TRY plant trait database (www.try-db.org) to be included in the next version release.
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- 2018
7. The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
- Author
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Thompson, P.M. (Paul), Stein, J.L., Medland, S.E. (Sarah), Hibar, D.P. (Derrek), Vásquez, A.A. (Arias), Rentería, M.E. (Miguel), Toro, R. (Roberto), Jahanshad, N. (Neda), Schumann, G. (Gunter), Franke, B. (Barbara), Wright, M.J. (Margaret), Martin, N.G. (Nicholas), Agartz, I. (Ingrid), Alda, M. (Martin), Alhusaini, S. (Saud), Almasy, L. (Laura), Alpert, K. (Kathryn), Andreasen, N.C., Andreassen, O.A. (Ole), Apostolova, L.G. (Liana), Appel, K. (Katja), Armstrong, N.J. (Nicola), Aribisala, B. (Benjamin), Bastin, M.E. (Mark), Bauer, M. (Michael), Bearden, C.E. (Carrie), Bergmann, Ø. (Ørjan), Binder, E.B. (Elisabeth), Blangero, J. (John), Bockholt, H.J., Bøen, E. (Erlend), Bois, M. (Monique), Boomsma, D.I. (Dorret), Booth, T. (Tom), Bowman, I.J. (Ian), Bralten, L.B.C. (Linda), Brouwer, R.M. (Rachel), Brunner, H.G., Brohawn, D.G. (David), Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Bustillo, J., Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cantor, R.M., Carless, M.A. (Melanie), Caseras, X. (Xavier), Cavalleri, G. (Gianpiero), Chakravarty, M.M. (M. Mallar), Chang, K.D. (Kiki), Ching, C.R.K. (Christopher), Christoforou, A. (Andrea), Cichon, S. (Sven), Clark, V.P., Conrod, P. (Patricia), Coppola, D. (Domenico), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Deary, I.J. (Ian), Geus, E.J.C. (Eco) de, Braber, A. (Anouk) den, Delvecchio, G. (Giuseppe), Depondt, C. (Chantal), Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Dima, D. (Danai), Dimitrova, R. (Rali), Djurovic, S. (Srdjan), Dong, H. (Hongwei), Donohoe, D.J. (Dennis), Duggirala, A. (Aparna), Dyer, M.D. (Matthew), Ehrlich, S.M. (Stefan), Ekman, C.J. (Carl Johan), Elvsåshagen, T. (Torbjørn), Emsell, L. (Louise), Erk, S., Espeseth, T. (Thomas), Fagerness, J. (Jesen), Fears, S. (Scott), Fedko, I. (Iryna), Fernandez, G. (Guillén), Fisher, S.E. (Simon), Foroud, T. (Tatiana), Fox, P.T. (Peter), Francks, C. (Clyde), Frangou, S. (Sophia), Frey, E.M. (Eva Maria), Frodl, T. (Thomas), Frouin, V. (Vincent), Garavan, H. (Hugh), Giddaluru, S. (Sudheer), Glahn, D.C. (David), Godlewska, B. (Beata), Goldstein, R.Z. (Rita), Gollub, R.L. (Randy), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Gruber, O. (Oliver), Guadalupe, T. (Tulio), Gur, R.E. (Raquel), Gur, R.C. (Ruben), Göring, H.H.H. (Harald), Hagenaars, S. (Saskia), Hajek, T. (Tomas), Hall, G.B. (Garry), Hall, J. (Jeremy), Hardy, J. (John), Hartman, C.A. (Catharina), Hass, J. (Johanna), Hatton, W., Haukvik, U.K. (Unn), Hegenscheid, K. (Katrin), Heinz, J. (Judith), Hickie, I.B. (Ian), Ho, B.C. (Beng ), Hoehn, D. (David), Hoekstra, P.J. (Pieter), Hollinshead, M. (Marisa), Holmes, A.J. (Avram), Homuth, G. (Georg), Hoogman, M. (Martine), Hong, L.E. (L.Elliot), Hosten, N. (Norbert), Hottenga, J.J. (Jouke Jan), Hulshoff Pol, H.E. (Hilleke), Hwang, K.S. (Kristy), Jack Jr., C.R. (Clifford), Jenkinson, S. (Sarah), Johnston, C., Jönsson, E.G. (Erik), Kahn, R.S. (René), Kasperaviciute, D. (Dalia), Kelly, S. (Steve), Kim, S. (Shinseog), Kochunov, P. (Peter), Koenders, L. (Laura), Krämer, B. (Bernd), Kwok, J.B.J. (John), Lagopoulos, J. (Jim), Laje, G. (Gonzalo), Landén, M. (Mikael), Landman, B.A. (Bennett), Lauriello, J., Lawrie, S. (Stephen), Lee, P.H. (Phil), Le Hellard, S. (Stephanie), Lemaître, H. (Herve), Leonardo, C.D. (Cassandra), Li, C.-S. (Chiang-shan), Liberg, B. (Benny), Liewald, D.C.M. (David), Liu, X. (Xinmin), Lopez, L.M. (Lorna), Loth, E. (Eva), Lourdusamy, A. (Anbarasu), Luciano, M. (Michelle), MacCiardi, F. (Fabio), Machielsen, M.W.J. (Marise), MacQueen, G.M. (Glenda), Malt, U.F. (Ulrik), Mandl, R. (René), Manoach, D.S. (Dara), Martinot, J.-L. (Jean-Luc), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), Mattingsdal, M. (Morten), Meyer-Lindenberg, A., McDonald, C. (Colm), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Mcmahon, K.L. (Katie), Meisenzahl, E. (Eva), Melle, I. (Ingrid), Milaneschi, Y. (Yuri), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant), Morris, D.W. (Derek W), Moses, E.K. (Eric), Mueller, B.A. (Bryon ), Muñoz Maniega, S. (Susana), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (Bertram), Mwangi, B. (Benson), Nauck, M. (Matthias), Nho, K. (Kwangsik), Nichols, T.E. (Thomas), Nilsson, L.G., Nugent, A.C. (Allison), Nyberg, L. (Lisa), Olvera, R.L. (Rene), Oosterlaan, J. (Jaap), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Papalampropoulou-Tsiridou, M. (Melina), Papmeyer, M. (Martina), Paus, T. (Tomas), Pausova, Z. (Zdenka), Pearlson, G. (Godfrey), Penninx, B.W.J.H. (Brenda), Peterson, C.P. (Charles), Pfennig, A. (Andrea), Phillips, M. (Mary), Pike, G.B. (G Bruce), Poline, J.B. (Jean Baptiste), Potkin, S.G. (Steven), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Rasmussen, J. (Jerod), Rietschel, M. (Marcella), Rijpkema, M. (Mark), Risacher, S.L. (Shannon), Roffman, J.L. (Joshua), Roiz-Santiañez, R. (Roberto), Romanczuk-Seiferth, N. (Nina), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rujescu, D. (Dan), Ryten, M. (Mina), Sachdev, P.S. (Perminder), Salami, A. (Alireza), Satterthwaite, T.D. (Theodore), Savitz, J. (Jonathan), Saykin, A.J. (Andrew), Scanlon, C. (Cathy), Schmaal, L. (Lianne), Schnack, H. (Hugo), Schork, N.J. (Nicholas), Schulz, S.C. (S.Charles), Schür, R. (Remmelt), Seidman, L.J. (Larry), Shen, L. (Li), Shoemaker, L. (Lawrence), Simmons, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soares, J.C. (Jair), Sponheim, S.R. (Scott), Sprooten, R. (Roy), Starr, J.M. (John), Steen, V.M. (Vidar), Strakowski, S. (Stephen), Strike, L.T. (Lachlan), Sussmann, J. (Jessika), Sämann, P.G. (Philipp), Teumer, A. (Alexander), Toga, A.W. (Arthur), Tordesillas-Gutierrez, D. (Diana), Trabzuni, D. (Danyah), Trost, S. (Sarah), Turner, J. (Jessica), Heuvel, M. (Martijn) van den, Wee, N.J. (Nic) van der, Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Valdés Hernández, M.C. (Maria), Veltman, D.J. (Dick), Versace, A. (Amelia), Völzke, H. (Henry), Walker, R. (Robert), Walter, H.J. (Henrik), Wang, L. (Lei), Wardlaw, J.M. (J.), Weale, M.E. (Michael), Weiner, M.W. (Michael), Wen, W. (Wei), Westlye, L.T. (Lars), Whalley, H.C. (Heather), Whelan, C.D. (Christopher), White, T.J.H. (Tonya), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Zilles, D. (David), Zwiers, M.P. (Marcel), Thalamuthu, A. (Anbupalam), Almeida, J.R. (Jorge), Schofield, C.J. (Christopher), Freimer, N.B. (Nelson), Lawrence, N.S. (Natalia), Drevets, D.A. (Douglas), Thompson, P.M. (Paul), Stein, J.L., Medland, S.E. (Sarah), Hibar, D.P. (Derrek), Vásquez, A.A. (Arias), Rentería, M.E. (Miguel), Toro, R. (Roberto), Jahanshad, N. (Neda), Schumann, G. (Gunter), Franke, B. (Barbara), Wright, M.J. (Margaret), Martin, N.G. (Nicholas), Agartz, I. (Ingrid), Alda, M. (Martin), Alhusaini, S. (Saud), Almasy, L. (Laura), Alpert, K. (Kathryn), Andreasen, N.C., Andreassen, O.A. (Ole), Apostolova, L.G. (Liana), Appel, K. (Katja), Armstrong, N.J. (Nicola), Aribisala, B. (Benjamin), Bastin, M.E. (Mark), Bauer, M. (Michael), Bearden, C.E. (Carrie), Bergmann, Ø. (Ørjan), Binder, E.B. (Elisabeth), Blangero, J. (John), Bockholt, H.J., Bøen, E. (Erlend), Bois, M. (Monique), Boomsma, D.I. (Dorret), Booth, T. (Tom), Bowman, I.J. (Ian), Bralten, L.B.C. (Linda), Brouwer, R.M. (Rachel), Brunner, H.G., Brohawn, D.G. (David), Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Bustillo, J., Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cantor, R.M., Carless, M.A. (Melanie), Caseras, X. (Xavier), Cavalleri, G. (Gianpiero), Chakravarty, M.M. (M. Mallar), Chang, K.D. (Kiki), Ching, C.R.K. (Christopher), Christoforou, A. (Andrea), Cichon, S. (Sven), Clark, V.P., Conrod, P. (Patricia), Coppola, D. (Domenico), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Deary, I.J. 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(Chiang-shan), Liberg, B. (Benny), Liewald, D.C.M. (David), Liu, X. (Xinmin), Lopez, L.M. (Lorna), Loth, E. (Eva), Lourdusamy, A. (Anbarasu), Luciano, M. (Michelle), MacCiardi, F. (Fabio), Machielsen, M.W.J. (Marise), MacQueen, G.M. (Glenda), Malt, U.F. (Ulrik), Mandl, R. (René), Manoach, D.S. (Dara), Martinot, J.-L. (Jean-Luc), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), Mattingsdal, M. (Morten), Meyer-Lindenberg, A., McDonald, C. (Colm), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Mcmahon, K.L. (Katie), Meisenzahl, E. (Eva), Melle, I. (Ingrid), Milaneschi, Y. (Yuri), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant), Morris, D.W. (Derek W), Moses, E.K. (Eric), Mueller, B.A. (Bryon ), Muñoz Maniega, S. (Susana), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (Bertram), Mwangi, B. (Benson), Nauck, M. (Matthias), Nho, K. (Kwangsik), Nichols, T.E. (Thomas), Nilsson, L.G., Nugent, A.C. (Allison), Nyberg, L. (Lisa), Olvera, R.L. (Rene), Oosterlaan, J. (Jaap), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Papalampropoulou-Tsiridou, M. (Melina), Papmeyer, M. (Martina), Paus, T. (Tomas), Pausova, Z. (Zdenka), Pearlson, G. (Godfrey), Penninx, B.W.J.H. (Brenda), Peterson, C.P. (Charles), Pfennig, A. (Andrea), Phillips, M. (Mary), Pike, G.B. (G Bruce), Poline, J.B. (Jean Baptiste), Potkin, S.G. (Steven), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Rasmussen, J. (Jerod), Rietschel, M. (Marcella), Rijpkema, M. (Mark), Risacher, S.L. (Shannon), Roffman, J.L. (Joshua), Roiz-Santiañez, R. (Roberto), Romanczuk-Seiferth, N. (Nina), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rujescu, D. (Dan), Ryten, M. (Mina), Sachdev, P.S. (Perminder), Salami, A. (Alireza), Satterthwaite, T.D. (Theodore), Savitz, J. (Jonathan), Saykin, A.J. (Andrew), Scanlon, C. (Cathy), Schmaal, L. (Lianne), Schnack, H. (Hugo), Schork, N.J. (Nicholas), Schulz, S.C. (S.Charles), Schür, R. (Remmelt), Seidman, L.J. (Larry), Shen, L. (Li), Shoemaker, L. (Lawrence), Simmons, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soares, J.C. (Jair), Sponheim, S.R. (Scott), Sprooten, R. (Roy), Starr, J.M. (John), Steen, V.M. (Vidar), Strakowski, S. (Stephen), Strike, L.T. (Lachlan), Sussmann, J. (Jessika), Sämann, P.G. (Philipp), Teumer, A. (Alexander), Toga, A.W. (Arthur), Tordesillas-Gutierrez, D. (Diana), Trabzuni, D. (Danyah), Trost, S. (Sarah), Turner, J. (Jessica), Heuvel, M. (Martijn) van den, Wee, N.J. (Nic) van der, Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Valdés Hernández, M.C. (Maria), Veltman, D.J. (Dick), Versace, A. (Amelia), Völzke, H. (Henry), Walker, R. (Robert), Walter, H.J. (Henrik), Wang, L. (Lei), Wardlaw, J.M. (J.), Weale, M.E. (Michael), Weiner, M.W. (Michael), Wen, W. (Wei), Westlye, L.T. (Lars), Whalley, H.C. (Heather), Whelan, C.D. (Christopher), White, T.J.H. (Tonya), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Zilles, D. (David), Zwiers, M.P. (Marcel), Thalamuthu, A. (Anbupalam), Almeida, J.R. (Jorge), Schofield, C.J. (Christopher), Freimer, N.B. (Nelson), Lawrence, N.S. (Natalia), and Drevets, D.A. (Douglas)
- Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
- Published
- 2014
- Full Text
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