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8. Preliminary efficacy of optimal pharmacotherapy and patient views in multiple myeloma.

Author

Manoharan, Amanda S., primary, Haines, Alex, additional, Assasi, Nazila, additional, Bryan, Matthew, additional, Boucher, Julie, additional, Gauthier, Graham, additional, Douma, Reuben, additional, Smith, Andrea, additional, Butcher, Robyn, additional, Ahuja, Tarry, additional, de Leseleuc, Louis, additional, Dyrda, Peter, additional, Blommestein, Hedwig M., additional, Thielen, Fredrick W., additional, and Leeneman, Brenda, additional

Published
2022
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9. Rituximab for the Treatment of Primary Membranous Nephropathy

Author

Islam, Saadul, primary, Janoudi, Ghayath, additional, Bryan, Matthew, additional, Perras, Christine, additional, Jabr, Mohammed, additional, Haines, Alex, additional, Assasi, Nazila, additional, Boucher, Julie, additional, Hafizi, Deba, additional, Lafleur, Phil, additional, Black, Cody, additional, Cornelissen, Tessa, additional, and Ford, Caitlyn, additional

Published
2022
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12. Additional file 5: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Network inconsistency evaluation. (PDF 59 kb)

Published
2019
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13. Additional file 3: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi
Abstract

Characteristics of included randomized controlled trials. (PDF 358 kb)

Published
2019
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14. Additional file 1: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Abstract

PRISMA flow diagram and full search strategy for Ovid MEDLINE. (PDF 623 kb)

Published
2019
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15. Additional file 4: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi
Abstract

Participant baseline characteristics of included randomized controlled trials. (PDF 398 kb)

Published
2019
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16. Additional file 6: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Abstract

Relative effects on outcomes of all pairs of interventions in Odds Ratios (95% credible intervals) as calculated from the network meta-analyses using fixed effects models. (PDF 122 kb)

Published
2019
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17. Additional file 2: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi, education
Abstract

Cochrane risk of bias assessment results. (PDF 375 kb)

Published
2019
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21. Men Working with Men in Intensive Family Services: Reflections on Violence, Trauma Lifeworlds, and Organic Interventions

Author

Alex Haines, Stuart Andary, Jackie Amos, Jonathon Louth, Amalie Mannik, Ruth Jacobs, Paul Best, Paul Calio, Travis Petrovic, Ryan Scott, Alex Vlahos, Haines, Alex, Andary, Stuart, Amos, Jackie, Louth, Jonathon, Mannik, Amalie, Jacobs, Ruth, Best, Paul, Calio, Paul, Petrovic, Travis, Scott, Ryan, and Vlahos, Alex

Subjects
trauma, Sociology and Political Science, parenting, shame, masculinity, Psychology (miscellaneous), family violence
Abstract

Intimate partner violence is a major problem in Australia, impacting many families that are on the cusp of disruption and intervention by the child protection system. Using an innovative method of inquiry, the article explores the role of dedicated men's workers in a South Australian non-government organisation's intensive family service that works towards keeping families safe and together. The dedicated men's worker positions are integrated into a multidisciplinary model that works with fathers who have been a part of situational violence within the family. The men's worker's (and co-authors') reflections offer insight into systemic barriers, practical therapeutic interventions, engagement work with fathers, how this is approached, and the various outcomes experienced. Blending auto-ethnography reflections, elements of rapid ethnographic assessment, and the use of rigorous and accelerated data reduction, we demonstrate the need for increased supports for fathers. These should include therapeutic engagement and working with the underlying trauma of fathers to ensure the whole family is supported and offered opportunity for healing and sustainable preservation. We also consider the more encompassing lifeworlds of the men and the need to drive and support broader sociocultural shifts. Refereed/Peer-reviewed

Published
2022
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22. Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4 α Is Mediated by a Novel Composite Regulatory Element.

Author

Mubarokah N, Hulin JA, Mackenzie PI, McKinnon RA, Haines AZ, Hu DG, and Meech R

Subjects
Caco-2 Cells, Enzyme Activation, Gene Expression Regulation, Neoplastic, Glucuronosyltransferase genetics, Humans, Liver enzymology, Promoter Regions, Genetic, UDP-Glucuronosyltransferase 1A9, CDX2 Transcription Factor metabolism, Glucuronosyltransferase metabolism, Hepatocyte Nuclear Factor 4 metabolism, Intestines enzymology
Abstract

The gastrointestinal tract expresses several UDP-glucuronosyltransferases (UGTs) that act as a first line of defense against dietary toxins and contribute to the metabolism of orally administered drugs. The expression of UGT1A8 , UGT1A9 , and UGT1A10 in gastrointestinal tissues is known to be at least partly directed by the caudal homeodomain transcription factor, CDX2. We sought to further define the factors involved in regulation of the UGT1A8-1A10 genes and identified a novel composite element located within the proximal promoters of these three genes that binds to both CDX2 and the hepatocyte nuclear factor (HNF) 4 α , and mediates synergistic activation by these factors. We also show that HNF4 α and CDX2 are required for the expression of these UGT genes in colon cancer cell lines, and show robust correlation of UGT expression with CDX2 and HNF4 α levels in normal human colon. Finally, we show that these factors are involved in the differential expression pattern of UGT1A8 and UGT1A10, which are intestinal specific, and that of UGT1A9, which is expressed in both intestine and liver. These studies lead to a model for the developmental patterning of UGT1A8, UGT1A9, and UGT1A10 in hepatic and/or extrahepatic tissues involving discrete regulatory modules that may function (independently and cooperatively) in a context-dependent manner., (Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics.)

Published
2018
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