8 results on '"Haimeur, Adil"'
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2. Fish Oil and Microalga Omega-3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High-Fat Fed Rats
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Haimeur, Adil, Mimouni, Virginie, Ulmann, Lionel, Martineau, Anne-Sophie, Messaouri, Hafida, Pineau-Vincent, Fabienne, Tremblin, Gérard, and Meskini, Nadia
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- 2016
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Catalog
3. Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases
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Mimouni Virginie, Ulmann Lionel, Haimeur Adil, Guéno Frédérique, Meskini Nadia, and Tremblin Gérard
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Microalgae ,Odontella aurita ,omega-3 polyunsaturated fatty acids ,food supplement ,cardiovascular diseases ,Oils, fats, and waxes ,TP670-699 - Abstract
Marine microalgae are photosynthetic microorganisms producing numerous bioactive molecules of interest for health and disease care such as lipids rich in omega-3 fatty acids -as eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3)- and carotenoids (e.g., β-carotene, fucoxanthin, astaxanthin). It has already been shown that these molecules, individually used, are benefic in the prevention of diseases such as those associated with the cardiovascular risks, but also in some carcinomas. When these molecules are combined, synergistic effects may be observed. Microalgae, as a dietary supplement, can be used to study these synergistic effects in animal models in which dyslipidemia can be induced by a nutrition treatment. Different marine microalgae of interest are studied in this context to determine their potential effect as an alternative source to marine omega-3 rich fish oils, actually widely used for human health. Actually, the pharmaceutical and nutrition industries are developing health research programs involving microalgae, trying to limit the dramatic reduction of fish stocks and the associated pollution in the marine environment. The aim of this review is threefold: (1) to present research on lipids, particularly long chain polyunsaturated fatty acids, as components of marine microalgae used as food supplements; (2) to present the health benefits of some microalgae or their extracts, in particular in the prevention of cardiovascular diseases and (3) to highlight the role of Odontella aurita, a marine microalga rich in EPA used as food supplement with the aim of preventing cardiovascular diseases. more...
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- 2015
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4. The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats
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Haimeur Adil, Ulmann Lionel, Mimouni Virginie, Guéno Frédérique, Pineau-Vincent Fabienne, Meskini Nadia, and Tremblin Gérard
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Odontella aurita ,n-3 PUFA ,Platelet aggregation ,Metabolic syndrome ,Oxidative stress ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Dietary changes are a major factor in determining cardiovascular risk. n-3 polyunsaturated fatty acids modulate the risk factors for metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism. We therefore investigated the effect of Odontella aurita, a microalga rich in EPA, which is already used as a food supplement, on the risk factors for high-fat diet induced metabolic syndrome in rats. Methods Male Wistar rats were divided into 4 groups and were fed with a standard diet (control); with the standard diet supplemented with 3% freeze-dried O. aurita (COA); with a high-fat diet (HF); or with the high-fat diet supplemented with 3% of freeze-dried O. aurita (HFOA) for 7 weeks. In this study we evaluated the impact of these different diets on the risk factors for metabolic syndrome, such as hyperlipidemia, platelet aggregation, thromboxane B2 production, and oxidative stress. Results After 7 weeks of treatment, high fat feeding had increased final body weight, glycemia, triacylglycerol, and total cholesterol levels in plasma and liver compared to the control diet. Collagen-induced platelet aggregation and basal platelet thromboxane B2 were also higher in the high-fat fed rats than in those in the control group. In the liver, oxidative stress was greater in the HF group than in the control group. O. aurita intake in HFOA-fed rats resulted in lower glycemia and lipid levels in the plasma and liver relative than in the HF group. Thus, in the HFOA group, n-3 polyunsaturated fatty acid levels in the tissues studied (plasma, liver, and platelets) were higher than in the HF group. Platelet hyper-aggregability tended to decrease in HFOA-fed rats as basal platelet thromboxane B2 production decreased. Finally, O. aurita reduced oxidative stress in the liver, with lower malondialdehyde levels and increased glutathione peroxidase activity. Conclusions O. aurita is a marine diatom rich in EPA as well as in other bioactive molecules, such as pigments. The synergistic effect of these microalgal compounds, displayed a beneficial effect in reducing the risk factors for high-fat induced metabolic syndrome: hyperlipidemia, platelet aggregation, and oxidative stress. more...
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- 2012
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5. Etude comparative de l’effet des microalgues marines et des huiles d’argan et de poisson sur le métabolisme lipidique et la fonction plaquettaire chez le rat et chez des patients dyslipidémiques : recherche de l'effet antiagrégant et exploration du mécanisme d'action dans le but de prévenir les maladies cardiovasculaires
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Haimeur, Adil, Mer, molécules et santé EA 2160 (MMS), Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Université du Maine, Université Hassan II (Mohammedia, Maroc). Faculté des sciences et techniques, Gérard Tremblin, Virginie Mimouni, Lionel Ulmann, Nadia Meskini, STAR, ABES, and Le Mans Université (UM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques more...
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Agrégation plaquettaire ,Argan oil ,Huile d'argan ,Odontella aurita ,Syndrome métabolique ,Huile de poisson ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,[SDV.BV] Life Sciences [q-bio]/Vegetal Biology ,Platelet aggregation ,Fish oil ,Metabolic syndrome - Abstract
Some risk factors, such as hyperlipidemia, hyperaggregability of blood platelets and oxidative stress promotes the progression of cardiovascular disease. The objective of this study was to compare the effects of LC-PUFA from different sources (marine microalgae, argan oil and fish oil) on installing the metabolic syndrome in rats fed high fat diet. The effects of argan oil on platelet function and lipid profiles were also tested in dyslipidemic patients. A preliminary study was conducted to find the minimum dose of microalgae (Odontella aurita) to be incorporated in the diet for a positive effect on the different parameters measured. We then studied the effect of lyophilized O. aurita on cardiovascular risk factors induced by a high fat diet in rats. The results showed that the addition of O. aurita induces a reduction in blood glucose and plasma lipid levels and a reduction in platelet aggregation. We then compare the effects of microalgae with fish oil. For this, a nutritional study was conducted in rats subjected to a high fat diet (HF) supplemented or not with the freeze-dried O. aurita (HFOA) or fish oil (HFFO). Supplementation lyophilized O. aurita and fish oil decreases platelet aggregation and oxidative stress.We subsequently compared the effects of fish oil rich in omega-3, and argan oil which is rich in omega-6 and omega-9. Our results show that 2 sources of LC-PUFA decrease platelet aggregation and the risk factors of metabolic syndrome, but their mechanism of action appears to be different.We have also conducted a clinical study in Morocco to investigate the antiplatelet and lipid lowering effect of argan oil in patients with dyslipidemia. The results show a significant improvement in atherogenic lipids in patients consuming argan oil for 3 weeks. This improvement consists in a very significant reduction in total cholesterol and serum LDL cholesterol, with a decreased platelet aggregation and oxidative stress in patients consuming argan oil., Certains facteurs de risque, comme l’hyperlipidémie, l’hyper-agrégabilité des plaquettes sanguines et le stress oxydant favorisent la progression des maladies cardiovasculaires. L’objectif de ce travail est de comparer les effets des AGPI-LC issus de sources différentes (microalgue marine, huile d’argan et de poisson) sur l’installation du syndrome métabolique chez des rats soumis à un régime hyperlipidique. Les effets de l’huile d’argan sur la fonction plaquettaire et sur le bilan lipidique ont aussi été testés chez des patients dyslipidémiques. Une étude préliminaire sur des rats a été réalisée afin de rechercher la dose minimale de la microalgue (Odontella aurita) à incorporer dans le régime pour obtenir un effet positif sur les différents paramètres mesurés. Nous avons ensuite étudié l’effet du lyophilisat d’O. aurita sur les facteurs de risque cardiovasculaire induits par un régime hyperlipidique chez le rat. Les résultats ont montré, que l'apport d'O. aurita induit une diminution de la glycémie et des teneurs en lipides plasmatiques ainsi qu’une réduction de l'agrégation plaquettaire. Nous avons ensuite comparé les effets de cette microalgue avec l’huile de poisson. Pour cela une étude nutritionnelle a été réalisée chez des rats soumis à un régime hyperlipidique supplémenté ou non avec du lyophilisat d’O. aurita ou de l’huile de poisson. Il a ainsi été montré que la supplémentation en lyophilisat d’O. aurita et en huile de poisson diminue l’agrégation plaquettaire et le stress oxydatif. Nous avons par la suite comparé les effets de l’huile de poisson riche en oméga-3, et de l’huile d’argan riche en oméga-6 et oméga-9. Nos résultats montrent que les 2 sources diminuent l’agrégation plaquettaire et les facteurs de risque du syndrome métabolique mais leurs mécanismes d’action semblent être différent. En complément Nous avons sur l’huile d’argan, réalisé au Maroc une étude clinique pour rechercher l’effet antiagrégant et hypolipémiant chez des patients dyslipidémiques. Les résultats obtenus montrent une amélioration significative des lipides athérogènes chez les patients consommant de l'huile d’argan. Cette amélioration consiste en une baisse très significative des taux de cholestérol total et de LDL-cholestérol sériques auxquels s'ajoutent une diminution de l’agrégation plaquettaire et du stress oxydatif chez les patients consommant de l'huile d’argan. more...
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- 2014
6. Odontella aurita-enriched diet prevents high fat diet-induced liver insulin resistance
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Amine, Hamza, primary, Benomar, Yacir, additional, Haimeur, Adil, additional, Messaouri, Hafida, additional, Meskini, Nadia, additional, and Taouis, Mohammed, additional
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- 2015
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7. Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)
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Haimeur, Adil, primary, Messaouri, Hafida, additional, Ulmann, Lionel, additional, Mimouni, Virginie, additional, Masrar, Azelarab, additional, Chraibi, Abdelmjid, additional, Tremblin, Gérard, additional, and Meskini, Nadia, additional more...
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- 2013
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8. Odontella aurita-enriched diet prevents high fat diet-induced liver insulin resistance.
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Amine, Hamza, Benomar, Yacir, Haimeur, Adil, Messaouri, Hafida, Meskini, Nadia, and Taouis, Mohammed
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HEPATITIS prevention , *HIGH-fat diet , *INSULIN resistance , *DIATOMS , *DIETARY supplements - Abstract
The beneficial effect of polyunsaturated omega-3 fatty acid (w-3 FAA) consumption regarding cardiovascular diseases, insulin resistance and inflammation has been widely reported. Fish oil is considered as the main source of commercialized w-3 FAA, and other alternative sources have been reported such as linseed or microalgae. However, despite numerous reports, the underlying mechanisms of action of w-3 FAA on insulin resistance are still not clearly established, especially those from microalgae. Here, we report that Odontella aurita, a microalga rich in w-3 FAA eicosapentaenoic acid, prevents high fat diet-induced insulin resistance and inflammation in the liver of Wistar rats. Indeed, a high fat diet (HFD) increased plasma insulin levels associated with the impairment of insulin receptor signaling and the up-regulation of toll-like receptor 4 (TLR4) expressions. Importantly, Odontella auritaenriched HFD (HFOA) reduces body weight and plasma insulin levels and maintains normal insulin receptor expression and responsiveness. Furthermore, HFOA decreased TLR4 expression, JNK/p38 phosphorylation and pro-inflammatory factors. In conclusion, we demonstrate for the first time, to our knowledge, that diet supplementation with whole Ondontella aurita overcomes HFD-induced insulin resistance through the inhibition of TLR4/JNK/p38 MAP kinase signaling pathways. [ABSTRACT FROM AUTHOR] more...
- Published
- 2016
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