Search

Purpose Wear failure happens frequently in rubber seal of high-speed rotating shaft because of the dry friction. Some traditional lubrication methods are not effective because of the restrictions on the relative high speed, temperature and others. This paper aims to present a new method of lubrication with gas film for the rotation shaft seal based on the contact design. Design/methodology/approach To obtain the generation condition of gas film and good effect of lubrication in the contact gap between the shaft and its seal, a series of micro-spiral grooves are designed on the contact surface of rubber seal so as to obtain a continuous dynamic pressure difference. Findings The result is that the distribution of the gas film in the micro-gap is continuous under the design of the spiral grooves and the contact with eccentricity because of the deformation of rubber seal, which is verified through the simulation calculation and experiment test. It is confirmed that the lubrication method with gas film through designing micro-spiral grooves on the contact surface is effective, and can achieve self-adaptive air lubrication for the high-speed shaft under the premise of the reliable sealing. Originality/value The method of gas film lubrication is realized through designing a microstructure of spiral grooves on the rubber surface to change the contact status, which can form a mechanism of adaptive lubrication to reduce the dry friction automatically in the contact gap. For the cross-scale difference between the rubber seal and gas film, a new modeling method is presented by building the mapping relation for the split blocks and repairing technique with integrated computer engineering and manufacturing, to reduce the possibility of nonconvergence and improve the efficiency and accuracy of calculation.

As one kind of porous elastic metal material, metal rubber is used in vibration isolation widely due to its better damping characteristic. During loading and unloading, the elastoplastic deformation and damping characteristics of this material are usually described by constructing its dynamic model. Although traditional models can describe the hysteresis performance, the accurate parameter identification of material structure under different preparation conductions is limited due to its complex expression or equivalent math form. In this paper, a dynamic hysteresis model is optimized through adding a dry friction damping term based on the micro-element analysis theory and analysis method of material mesoscopic structure. The relation among the manufacture technic, size of metal wire and vibration parameters were established, which accurately describes hysteresis characteristic of metal rubber by dry friction when the metal wires are in the state of slipping contact. The result is verified by the harmonic vibration experiment that the model has good adaptability and convenience, especially can improve the accuracy and convenience of parameter identification on the forming materials of metal rubber.

In frictional wear study of shaft seal, a refined description of contact surface topography is needed, but it is difficult to directly obtain the contact characteristics like the actual contact area and the corresponding contact states due to a tiny contact gap of metalrubber contact. Traditionally, a measuring observation apparatus is used to collect the surface information during the dynamic contact, but is limited by the accuracy and more cost. In this paper, a new method is proposed to investigate a refined contact area of rubber surface during the dynamic contact through reconstructing the micro topography. A metal-rubber contact model is established based on the coordinate cloud built by the height distribution function of the asperities. According to the model, the finite element simulation on metal-rubber contact is conducted in ANSYS APDL and the frictional contact behavior under different roughness is discussed. The result shows there is a power exponent relation between the actual contact area and the external pressure, and four contact states, no contact, initial contact, adhesion contact and sliding contact, exist in the process. It gives an effective way to determine the dynamic actual contact area in the frictional wear study of rubber material, and offers an effective modelling method with quantitative scale to study the micro contact properties for rigid-flexible contact situations.

Background Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the intensive care unit (ICU). Therefore, establishing a risk model that predicts admission to ICU is meaningful in preventing patients from post-operation deterioration and potentially reducing socio-economic burden. Methods We retrospectively collected 120 clinical features from 1242 PDAC patients, including demographic data, pre-operative and intra-operative blood tests, in-hospital duration, and ICU status. Machine learning pipelines, including Supporting Vector Machine (SVM), Logistic Regression, and Lasso Regression, were employed to choose an optimal model in predicting ICU admission. Ordinary least-squares regression (OLS) and Lasso Regression were adopted in the correlation analysis of post-operative bleeding, total in-hospital duration, and discharge costs. Results SVM model achieved higher performance than the other two models, resulted in an AU-ROC of 0.80. The features, such as age, duration of operation, monocyte count, and intra-operative partial arterial pressure of oxygen (PaO2), are risk factors in the ICU admission. The protective factors include RBC count, analgesic pump dexmedetomidine (DEX), and intra-operative maintenance of DEX. Basophil percentage, duration of the operation, and total infusion volume were risk variables for staying in ICU. The bilirubin, CA125, and pre-operative albumin were associated with the post-operative bleeding volume. The operation duration was the most important factor for discharge costs, while pre-lymphocyte percentage and the absolute count are responsible for less cost. Conclusions We observed that several new indicators such as DEX, monocyte count, basophil percentage, and intra-operative PaO2 showed a good predictive effect on the possibility of admission to ICU and duration of stay in ICU. This work provided an essential reference for indication in advance to PDAC operation.

Quantum information can be coded by the topologically protected edges of fractional quantum Hall (FQH) states. Investigation on FQH edges in the hope of searching and utilizing non-Abelian statistics has been a focused challenge for years. Manipulating the edges, e.g. to bring edges close to each other or to separate edges spatially, is a common and essential step for such studies. The FQH edge structures in a confined region are typically presupposed to be the same as that in the open region in analysis of experimental results, but whether they remain unchanged with extra confinement is obscure. In this work, we present a series of unexpected plateaus in a confined single-layer two-dimensional electron gas (2DEG), which are quantized at anomalous fractions such as 9/4, 17/11, 16/13 and the reported 3/2. We explain all the plateaus by assuming surprisingly larger filling factors in the confined region. Our findings enrich the understanding of edge states in the confined region and in the applications of gate manipulation, which is crucial for the experiments with quantum point contact and interferometer., Comment: 6 pages, 4 figures

Objectives To determine the impact of the Coronavirus disease-2019 (COVID-19) pandemic on the length of stay (LOS) and prognosis of patients in the emergency department (ED). Methods A retrospective review of case data of patients in the ED during the early stages of the COVID-19 pandemic in the First Affiliated Hospital of Soochow University (January 15, 2020– January 14, 2021) was performed and compared with that during the pre-COVID-19 period (January 15, 2019 – January 14, 2020). Patient information including age, sex, length of stay, and death was collected. Wilcoxon Rank sum test was utilized to compare the difference in LOS between the two cohorts. Chi-Squared test was utilized to analyze the prognosis of patients. The LOS and prognosis in different departments (emergency internal medicine, emergency surgery, emergency neurology, and other departments) were further analyzed. Results Of the total 8278 patients, 4159 (50.24%) were ordered in the COVID-19 pandemic group and 4119 (49.76%) were ordered in the pre-COVID-19 group. The length of stay prolongs significantly in the COVID-19 group compared with that in the pre-COVID-19 group(13h vs 9.8h; p < 0.001). There was no significant difference in mortality between the two cohorts (4.8% VS 5.3%; p=0.341). Conclusion The COVID-19 pandemic was associated with a significant increase in the length of stay, which may lead to emergency department crowding. And the influence of the COVID-19 pandemic on patients in different emergency departments is different. There is no significant impact on the LOS of emergency neuropathy. Across departments, COVID-19 didn’t have a significant impact on the prognosis of ED patients.

The technology can be considered a systematic, knowledge-based action, applicable in industrial processes in order to transform resources into products requested by the customer. Technology uses scientific resources but is, at the same time, itself a science of applying knowledge for practical purposes. Technology is ultimately the measure of the efficiency of industrial management. The management, as a science, takes the information regarding the management processes and submits them to some analysis procedures in order to perfect the existing management methods and to complete them with new ones. The applicative character of the management results from the fact that the experiences regarding the systems management are materialized in the design of new systems, methods, techniques, and procedures that constitute the tools made available to the managers for achieving the company's objectives. The manager must prove the ability to understand economic and social phenomena, the laws that govern them, objectively identifying the risks and opportunities, in order to plan the company's activities. An equidistant, efficient and coherent policy established by the management guarantees the success and ensures the agreement of the company's existence with the market evolution.

Exosomes are an emerging therapeutic tool for the treatment of tissue injuries. In the present study, the protective effect of isolated exosomes from adipose‑derived stem cells (ADSCs‑exo) against hepatic ischemia‑reperfusion (I/R) injury was explored. Hepatic I/R injury was achieved by inducing ischemia for 60 min followed by reperfusion for 2 and 6 h. Pre‑treatment with ADSCs‑exo revealed a significant reduction in necrosis and apoptosis in liver tissue induced by I/R injury. Hypoxic oxidative stress was managed by exosome‑mediated reduced reactive oxygen species and increased superoxide dismutase that in turn protected mitochondrial damage and apoptosis. Reduction in inflammatory mediators such as IL‑1β and TNF‑α was also observed and protection of hepatocytes from I/R injury was evidenced by a significant decrease in biochemical markers of liver damage (alanine transaminase, aspartate transaminase and lactate dehydrogenase). Exosomal prostaglandin E2 (PGE2)‑mediated ERK1/2 and GSK‑3β phosphorylation were revealed to increase Bcl‑2 and decrease Bax expression with mitochondrial permeability transition pore‑inhibition which may be considered a prime mechanism of exosome‑mediated hepatoprotection. In conclusion, our results indicated that ADSCs‑exo pre‑treatment is effective in protecting liver I/R injury.

Objectives To determine the impact of the Coronavirus disease-2019 (COVID-19) pandemic on the length of stay (LOS) and prognosis of patients in the resuscitation area. Methods A retrospective analysis of case data of patients in the resuscitation area during the early stages of the COVID-19 pandemic (January 15, 2020– January 14, 2021) was performed and compared with the pre-COVID-19 period (January 15, 2019 – January 14, 2020) in the First Affiliated Hospital of Soochow University. The patients’ information, including age, sex, length of stay, and death, was collected. The Wilcoxon Rank sum test was performed to compare the LOS difference between the two periods. Fisher's Exact test and Chi-Squared test were used to analyze the prognosis of patients. The LOS and prognosis in different departments of the resuscitation area (emergency internal medicine, emergency surgery, emergency neurology, and other departments) were further analyzed. Results Of the total 8278 patients, 4159 (50.24%) were enrolled in the COVID-19 pandemic period group, and 4119 (49.76%) were enrolled pre-COVID-19 period group. The length of stay was prolonged significantly in the COVID-19 period compared with the pre-COVID-19 period (13h VS 9.8h, p < 0.001). The LOS in the COVID-19 period was prolonged in both emergency internal medicine (15.3h VS 11.3h, p < 0.001) and emergency surgery (8.7h VS 4.9h, p < 0.001) but not in emergency neurology or other emergency departments. There was no significant difference in mortality between the two cohorts (4.8% VS 5.3%, p = 0.341). Conclusion The COVID-19 pandemic was associated with a significant increase in the length of resuscitation area stay, which may lead to resuscitation area crowding. The influence of the COVID-19 pandemic on patients of different departments was variable. There was no significant impact on the LOS of emergency neurology. According to different departments of the resuscitation area, the COVID-19 pandemic didn’t significantly impact the prognosis of patients.

Even-denominator fractional quantum Hall (FQH) states, such as 5/2 and 7/2, have been well known in a two-dimensional electron gas (2DEG) for decades and are still investigated as candidates of non-Abelian statistics. In this paper, we present the observation of a 3/2 FQH plateau in a single-layer 2DEG with lateral confinement at a bulk filling factor of 5/3. The 3/2 FQH plateau is quantized at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left( {\frac{h}{{e^2}}} \right)/\left( {\frac{3}{2}} \right)$$\end{document}he2∕32 within 0.02%, and can survive up to 300 mK. This even-denominator FQH plateau may imply intriguing edge structure and excitation in FQH system with lateral confinement. The observations in this work demonstrate that understanding the effect of the lateral confinement on the many-body system is critical in the pursuit of important theoretical proposals involving edge physics, such as the demonstration of non-Abelian statistics and the realization of braiding for fault-tolerant quantum computation., Fractional quantum Hall states in 2D electron gases arise due to strong electron-electron interactions, which makes a general theoretical understanding difficult. Fu et al. present data showing the ν = 5/3 quantum Hall state has a 3/2 plateau in the diagonal resistance that has not been captured by existing models.

In the Landau levels of a two-dimensional electron system or when flat bands are present, e.g. in twisted van der Waals bilayers, strong electron-electron interaction gives rise to quantum Hall ferromagnetism with spontaneously broken symmetries in the spin and isospin sectors. Quantum Hall ferromagnets support a rich variety of low-energy collective excitations that are instrumental to understand the nature of the magnetic ground states and are also potentially useful as carriers of quantum information. Probing such collective excitations, especially their dispersion {\omega}(k), has been experimentally challenging due to small sample size and measurement constraints. In this work, we demonstrate an all-electrical approach that integrates a Fabry-P\'erot cavity with non-equilibrium transport to achieve the excitation, wave vector selection and detection of spin waves in graphene heterostructures. Our experiments reveal gapless, linearly dispersed spin wave excitations in the E = 0 Landau level of bilayer graphene, thus providing direct experimental evidence for a predicted canted antiferromagnetic order. We show that the gapless spin wave mode propagates with a high group velocity of several tens of km/s and maintains phase coherence over a distance of many micrometers. Its dependence on the magnetic field and temperature agree well with the hydrodynamic theory of spin waves. These results lay the foundation for the quest of spin superfluidity in this high-quality material. The resonant cavity technique we developed offers a powerful and timely method to explore the collective excitation of many spin and isospin-ordered many-body ground states in van der Waals heterostructures and open the possibility of engineering magnonic devices., Comment: 17 figures. To appear in PRX

A two-dimensional electron system placed in a magnetic field develops Landau levels, where strong Coulomb interactions lead to the appearance of many-body correlated ground states. Quantum numbers similar to the electron spin enable the understanding and control of complex ground state order and collective excitations. Owing to its spin, valley and orbital degrees of freedom, Bernal-stacked bilayer graphene offers a rich platform to pursue correlated phenomena in two dimensions. In this work, we fabricate dual-gated Bernal-stacked bilayer graphene devices and demonstrate unprecedented fine control over its valley isospin degrees of freedom using a perpendicular electric field. Higher sample quality enables us to probe regimes obscured by disorder in previous studies. We present evidence for a new even-denominator fractional quantum Hall state at filling factor {\nu} = 5/2. The 5/2 state is found to be spontaneously valley polarized in the limit of vanishing valley Zeeman splitting, consistent with a theoretical prediction made regarding the spin polarization of the Moore-Read state. In the vicinity of the even-denominator fractional quantum Hall states, we observe the appearance of the predicted Levin-Halperin daughter states of the Moore-Read Pfaffian wave function at {\nu}= 3/2, 7/2 and of the anti-Pfaffian at {\nu}= 5/2 and -1/2. These observations suggest the breaking of particle-hole symmetry in bilayer graphene. We construct a comprehensive valley polarization phase diagram for the Jain sequence fractional states surrounding filling factor 3/2. These results are well explained by a two-component composite fermion model, further demonstrating the SU(2) nature of the valley isospin in bilayer graphene. Our experiment paves the path for future efforts of manipulating the valley isospin in bilayer graphene to engineer exotic topological orders and quantum information processes., Comment: 24 pages, 14 figures. The changes reported in the erratum are included in the latest version

The spin-polarized even-denominator fractional quantum Hall (FQH) states in the second Landau level (LL), i.e. 5/2 and 7/2, may possess novel quasi-particle excitations obeying non-Abelian statistics. However, the spin polarization of the 7/2 FQH state has not been investigated experimentally and the spin polarization of the 5/2 FQH state from tilted field experiments remains controversial. Using a piezo-driven sample rotator with the lowest electron temperature down to 25 mK, we studied the energy gap of the even-denominator FQH states in the second LL by precise control of the tilted angles with a resolution less than 0.1{\deg}. We observed two different energy gap dependences on the in-plane magnetic field for 5/2, 7/2, other FQH states (7/3 and 8/3) in the second LL and reentrant integer quantum Hall (RIQH) states in the third LL. Though the transition fields vary from states, their corresponding in-plane magnetic lengths are comparable to the quantum well thickness of the sample, which may result from the influence of the finite-thickness effect. At low in-plane magnetic fields, before the conjectured finite-thickness effect starts to dominate, the energy gaps of both 5/2 and 7/2 states show a non-decreasing behavior, supporting spin-polarized ground states. Our results also suggest that the 7/3, 8/3 FQH states, and the RIQH states in the third LL are spin-polarized or partially spin-polarized.

Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands. Our previous studies showed that myeloid-derived suppressor cells (MDSCs) exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome (ESS), but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS. In this study, we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes (OE-MSC-Exos) significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels. Moreover, treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice. Mechanistically, OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs. In addition, the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling, indicating an autocrine pathway of MDSC functional modulation by IL-6. Taken together, our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs, possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases.

Additional file 1 : Supplementary figure 1. The top features of the predictive model for post-operative admission to ICU.

We report on Andreev reflections at clean $\mathrm{NbS}{\mathrm{e}}_{2}$-bilayer graphene junctions. The high transparency of the junction, which manifests as a large conductance enhancement of up to 1.8, enables us to see clear evidence of a proximity-induced superconducting gap in bilayer graphene and two Andreev reflections through a vertical $\mathrm{NbS}{\mathrm{e}}_{2}$-graphene and a lateral graphene-graphene junction, respectively. Quantum transport simulations capture the complexity of the experimental data and illuminate the impact of various microscopic parameters on the transmission of the junction. Our work establishes the practice and understanding of an all-van-der-Waals, high-performance superconducting junction. The realization of a highly transparent proximized graphene-graphene junction opens up possibilities to engineer emergent quantum phenomena.

Heterostructures formed between two different van der Waals materials enable interactions and functionalities absent in each component. In this work we show that vicinity to an atomically thin ${\mathrm{WSe}}_{2}$ sheet dramatically impacts the energies of the symmetry-broken low Landau levels of bilayer graphene, possibly due to Coulomb screening. We present a systematic study of the magnetic field and electrical displacement field dependences of the Landau level gaps at filling factor $\ensuremath{\nu}=1$, 2, 3, and compare to boron nitride encapsulated pristine bilayer graphene. The exchange-dominated energy splitting between the $N=0$ and 1 orbital wave functions is significantly enhanced, which leads to a modified phase diagram at filling factor $\ensuremath{\nu}=0$ and larger energy gaps at $\ensuremath{\nu}=1$ and 3 in ${\mathrm{WSe}}_{2}$/bilayer graphene heterostructures. The exchange-enhanced spin gap at $\ensuremath{\nu}=2$, on the other hand, is reduced by approximately twofold. Our results demonstrate a possible way to engineer quantum Hall phenomena via van der Waals heterostructures.

The plateau-plateau transition in the integer quantum Hall effect is studied in three Hall bars with different widths. The slopes of the Hall resistance as a function of magnetic field follow the scaling power law as expected in the plateau-plateau transition, and saturate at the low temperature limit. Surprisingly, the saturation temperature is irrelevant with the Hall bar size, which suggests that the saturation of the coherence length is intrinsic.

The deficiency or mutation of p53 has been linked to several types of cancers. The mesenchymal stem cell (MSC) is an important component in the tumor microenvironment, and exosomes secreted by MSCs can transfer bioactive molecules, including proteins and nucleic acid, to other cells in the tumor microenvironment to influence the progress of a tumor. However, whether the state of p53 in MSCs can impact the bioactive molecule secretion of exosomes to promote cancer progression and the regulatory mechanism remains elusive. Our study aimed to investigate the regulation of ubiquitin protein ligase E3 component n-recognin 2 (UBR2) enriched in exosomes secreted by p53 deficient mouse bone marrow MSC (p53–/–mBMMSC) in gastric cancer progression in vivo and in vitro. We found that the concentration of exosome was significantly higher in p53–/–mBMMSC than that in p53 wild-type mBMMSC (p53+/+mBMMSC). In particular, UBR2 was highly expressed in p53–/–mBMMSC cells and exosomes. P53–/–mBMMSC exosomes enriched UBR2 could be internalized into p53+/+mBMMSC and murine foregastric carcinoma (MFC) cells and induce the overexpression of UBR2 in these cells which elevated cell proliferation, migration, and the expression of stemness-related genes. Mechanistically, the downregulation of UBR2 in p53–/–mBMMSC exosomes could reverse these actions. Moreover, a majority of Wnt family members, β-catenin, and its downstream genes (CD44, CyclinD1, CyclinD3, and C-myc) were significantly decreased in MFC knockdown UBR2 and β-catenin depletion, an additional depletion of UBR2 had no significant difference in the expression of Nanog, OCT4, Vimentin, and E-cadherin. Taken together, our findings indicated that p53–/–mBMMSC exosomes could deliver UBR2 to target cells and promote gastric cancer growth and metastasis by regulating Wnt/β-catenin pathway.

Two-dimensional (2D) transition metal dichalcogenides (TMDs) have a range of unique physics properties and could be used in the development of electronics, photonics, spintronics and quantum computing devices. The mechanical exfoliation technique of micro-size TMD flakes has attracted particular interest due to its simplicity and cost effectiveness. However, for most applications, large area and high quality films are preferred. Furthermore, when the thickness of crystalline films is down to the 2D limit (monolayer), exotic properties can be expected due to the quantum confinement and symmetry breaking. In this paper, we have successfully prepared macro-size atomically flat monolayer NbSe2 films on bilayer graphene terminated surface of 6H-SiC(0001) substrates by molecular beam epitaxy (MBE) method. The films exhibit an onset superconducting critical transition temperature above 6 K, 2 times higher than that of mechanical exfoliated NbSe2 flakes. Simultaneously, the transport measurements at high magnetic fields reveal that the parallel characteristic field Bc// is at least 4.5 times higher than the paramagnetic limiting field, consistent with Zeeman-protected Ising superconductivity mechanism. Besides, by ultralow temperature electrical transport measurements, the monolayer NbSe2 film shows the signature of quantum Griffiths singularity when approaching the zero-temperature quantum critical point.

Salidroside (Sal) is a natural antioxidant that elicits cardioprotective and neuroprotective effects in vivo and in vitro; however, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. The purpose of this study was to investigate the hepatoprotective effects of salidroside against segmental (70%) warm hepatic I/R injury in rats. Animals were randomized into Sham, Sham+salidroside pretreatment (Sal), Sham+Sal+carboxyatractyloside (CATR), Sham+CATR, I/R, I/R+Sal, I/R+Sal+CATR and I/R+CATR groups. The hepatic artery, left portal vein and median liver lobes were occluded for 60min and then unclamped to allow reperfusion. Pretreatment with salidroside (20mg/kg/day for 7 days, intraperitoneally) significantly decreased serum alanine aminotransferase (sALT) and serum aspartate aminotransferase (sAST) levels after 6h and 24h of reperfusion and protected the liver against I/R-induced injury. However, this protective effect could be reversed by CATR, a mitochondrial permeability transition pore (MPTP) opener (5mg/kg 30min before I/R insult, intraperitoneally). Mechanistic studies have revealed that salidroside inhibits glycogen synthase kinase-3 beta (GSK-3β) activity and enhances the NF-E2-related factor (Nrf2)-dependent antioxidant response by activating the Akt signaling pathway, thereby reducing mitochondrial reactive oxygen species generation, increasing MPTP resistance and preventing apoptosis by suppressing cytochrome c release and caspase activation during reperfusion. Therefore, salidroside ameliorates hepatocyte death and apoptosis through activation of the GSK-3β/Nrf2-dependent antioxidant response and subsequent MPTP inhibition. These results provide experimental evidence supporting the clinical use of salidroside for hepatoprotection in surgical settings.

Fiber-reinforced composite laminates (FRCL) is susceptible to the external impacting. Understanding the crack propagation and structural mechanical properties of the damaged FRCL under low-velocity oblique impact is of great value in practical application. A new analytical dynamic model is developed in this work to research the dynamic response and damage property of FRCL under oblique impacting. The displacement field and strain–displacement relations of the FRCL are established by utilizing higher-order shear plate theory. The matrix damage and fiber rupture in FRCL under oblique impacting are captured by an internal variable-based continuum damage constitutive relation. To accurately predict the oblique impacting force, an analytical dynamic impacting model is proposed basing on a developed contact model, where normal and tangential contact is coupled and solved simultaneously. The whole initial boundary value problem is iteratively solved by synthetically using finite differential method and Newmark- $$\beta $$ method. The solving convergence and accuracy of the model is demonstrated and validated. Simulations show that the matrix damage is more easily to appear in FRCL under shear force due to oblique contact when under oblique impacting, and the damage profile is different from normal impacting. The dynamic responses of the FRCL plate under oblique impacting differ also greatly from normal impacting. The current research provides a theoretical basis for FRCL design and its engineering application when under low-velocity impacting.