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6. Contributors

Author

Agarwal, Ashok, primary, Aitken, R. John, additional, Alves, Marco G., additional, Baker, Mark A., additional, Bui, Albert D., additional, Caraballo, Meaghanne, additional, Chainy, Gagan B.N., additional, Chen, Shu-Jian, additional, Cheng, Julie W., additional, Cho, Chak-Lam, additional, De Iuliis, Geoffrey N., additional, Drevet, Joel R., additional, Durairajanayagam, Damayanthi, additional, Garrido, Nicolás, additional, Gunes, Sezgin, additional, Gupta, Sajal, additional, Haidl, Gerhard, additional, Henkel, Ralf R., additional, Hotaling, James M., additional, Jena, Soumya Ranjan, additional, Jena, Srikanta, additional, Ko, Edmund Y., additional, Leisegang, Kristian, additional, Mahmutoglu, Asli M., additional, Nayak, Jasmine, additional, Netherton, Jacob, additional, Oliveira, Pedro F., additional, Owyong, Michael, additional, Panner Selvam, Manesh Kumar, additional, Patel, Biren V., additional, Ramasamy, Ranjith, additional, Rato, Luís, additional, Rivera, Rocío, additional, Sabanegh, Edmund, additional, Sahoo, Dipak Kumar, additional, Samanta, Luna, additional, Sharma, Rakesh, additional, Sikka, Suresh C., additional, Silva, Branca M., additional, Solomon, Michael C., additional, Sousa, Mário, additional, Tadros, Nicholas N., additional, Taşkurt, Gülgez Neslihan Hekim, additional, Toor, Jaideep S., additional, Tremellen, Kelton, additional, Tvrda, Eva, additional, and Vij, Sarah C., additional

Published
2019
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8. Myd88 Signaling Is Involved in the Inflammatory Response in LPS-Induced Mouse Epididymitis and Bone-Marrow-Derived Dendritic Cells

Author

Liu, Jin-Chuan, primary, Wang, Peng, additional, Zeng, Qun-Xiong, additional, Yang, Chen, additional, Lyu, Minmin, additional, Li, Yanfeng, additional, Yeung, William Shu-Biu, additional, Chiu, Philip Chi-Ngong, additional, Haidl, Gerhard, additional, Allam, Jean-Pierre, additional, and Duan, Yong-Gang, additional

Published
2023
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9. Strumenti diagnostici

Author

Hargreave, Timothy B., Comhaire, Frank, Mahmoud, Ahmed, Schiefer, Hans Gerd, von Graevenitz, Alexander, Klingmüller, Dietrich, Bliesener, N., Haidl, Gerhard, Bracke, Marc E., Nijs, Els L. F., Oyen, Raymond H., Gat, Yigal, Gornish, Michael, Bergmann, Martin, Elliott, David J., Tatarov, Oleg, Kirk, David, Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, Hargreave, Timothy B., editor, Lenzi, Andrea, editor, and Isidori, Andrea M., editor

Published
2010
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10. Fattori maschili dei disturbi della fertilità

Author

Comhaire, Frank, Mahmoud, Ahmed, Hargreave, Timothy B., Haidl, Gerhard, Weber, R. F. A., Dohle, Gert R., Schill, Wolf-Bernhard, editor, Comhaire, Frank, editor, Hargreave, Timothy B., editor, Lenzi, Andrea, editor, and Isidori, Andrea M., editor

Published
2010
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11. Andrologie

Author

Wolff, Hans, Haidl, Gerhard, Köhn, Frank-Michael, Schill, Wolf-Bernhard, Plewig, Gerd, editor, Kaudewitz, Peter, editor, and Sander, Christian A., editor

Published
2005
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12. Andrologie

Author

Wolff, Hans, Ochsendorf, Falk, Haidl, Gerhard, Köhn, Frank-Michael, Schill, Wolf-Bernhard, Plewig, Gerd, editor, and Degitz, Klaus, editor

Published
2001
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16. Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece

Author

Kim, Young-Hwan, Haidl, Gerhard, Schaefer, Martina, Egner, Ursula, Mandal, Arabinda, and Herr, John C.

Subjects
Enzymes, Spermatozoa, Biological sciences
Abstract

Byline: Young-Hwan Kim (a), Gerhard Haidl (b), Martina Schaefer (c), Ursula Egner (c), Arabinda Mandal (a), John C. Herr (a) Keywords: Fibrous sheath; Glycolytic enzymes; Sperm flagellar energy carrier; ADP/ATP carrier; Sperm glycolysis; Principal piece; Energy production; Energy translocation; Sperm motility Abstract: The longest part of the sperm flagellum, the principal piece, contains the fibrous sheath, a cytoskeletal element unique to spermiogenesis. We performed mass spectrometry proteomics on isolated human fibrous sheaths identifying a unique ADP/ATP carrier protein, SFEC [AAC4], seven glycolytic enzymes previously unreported in the human sperm fibrous sheath, and sorbitol dehydrogenase. SFEC, pyruvate kinase and aldolase were co-localized by immunofluorescence to the principal piece. A homology model constructed for SFEC predicted unique residues at the entrance to the nucleotide binding pocket of SFEC that are absent in other human ADP/ATP carriers, suggesting opportunities for selective drug targeting. This study provides the first evidence of a role for an ADP/ATP carrier family member in glycolysis. The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece. A model is proposed that the fibrous sheath represents a highly ordered complex, analogous to the electron transport chain, in which adjacent enzymes in the glycolytic pathway are assembled to permit efficient flux of energy substrates and products with SFEC serving to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. Author Affiliation: (a) Center for Research in Contraceptive and Reproductive Health, Department of Cell Biology, University of Virginia, Charlottesville, PO Box 800732, VA 22908, USA (b) Department of Dermatology/Andrology Unit, University of Bonn, Bonn, Germany (c) Research Center Europe, Enabling Technologies, Schering AG, 13342 Berlin, Germany Article History: Received 2 June 2006; Revised 28 September 2006; Accepted 4 October 2006

Published
2007

17. Update Andrologie

Author

Köhn, Frank-Michael, primary, Schuppe, Hans-Christian, additional, and Haidl, Gerhard, additional

Published
2013
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18. Autorenverzeichnis

Author

Rascher, Wolfgang, primary, Atta, Johannes, additional, Autenrieth, I.B., additional, Becker, Karsten, additional, Benz, Marcus, additional, Berner, Reinhard, additional, Bork, Konrad, additional, Carl, Hans-Dieter, additional, Castell, S., additional, Enzensberger, W., additional, Epple, Hans-Jörg, additional, Feußner, Hubertus, additional, Fiegel, P., additional, Fischbach, Wolfgang, additional, Fölsch, U.R., additional, Frank, Wolfgang, additional, Friese, K., additional, Gingelmaier, Andrea, additional, Goebel, Frank-Detlef, additional, Grosch-Wörner, Ilse, additional, Haidl, Gerhard, additional, Hammer, Michael, additional, Handrick, W., additional, Hauer, Thomas, additional, Hörmann, K., additional, Hornung, Thomas, additional, Jelinek, Tomas, additional, Jendrissek, Klaus Andreas, additional, Kiehne, Karlheinz, additional, Klein, Matthias, additional, Kneitz, Christian, additional, Köhler, Henrik, additional, Köhler, Lars, additional, Koletzko, Sibylle, additional, Kuipers, Jens Gert, additional, Lammert, Frank, additional, Lembcke, B., additional, Loddenkemper, R., additional, Lorenz, J., additional, Löscher, T., additional, Lux, Gerd, additional, Magdorf, K., additional, Meinertz, Thomas, additional, Melichar, Volker, additional, Meyer, H.J., additional, Nattermann, Jacob, additional, Nicolai, T., additional, Niehues, Tim, additional, Passlick, Bernward, additional, Petersen, Eiko E., additional, Pfaffenbach, Boris, additional, Pfister, Hans-Walter, additional, Pilatz, Adrian, additional, Pohl-Koppe, Annette, additional, Prange, H., additional, Reinhardt, D., additional, Rietschel, Ernst, additional, Roos, Reinhard, additional, Ruhnke, Markus, additional, Schaal, K.P., additional, Schifferdecker, Michael, additional, Schliep, Stefan, additional, Schneider, Thomas, additional, Scholz, H., additional, Schraml, Annemarie, additional, Schuster, V., additional, Schwarz, Tino F., additional, Seybold, Ulrich, additional, Siemon, G., additional, Spengler, Ulrich, additional, Sticherling, Michael, additional, Stremmel, Christian, additional, Stuck, B.A., additional, Völkl, Thomas M.K., additional, Wagenlehner, Florian E.M., additional, Weber, Lutz, additional, Weidner, Wolfgang, additional, Weinke, Thomas, additional, Weiß, M., additional, Wintergerst, Uwe, additional, Zeitz, Martin, additional, and Zimmermann, Theodor, additional

Published
2013
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25. Andrology

Author

UrgenGlander, Hans-JÜ, Haidl, Gerhard, Köhn, Frank-Michael, Ochsendorf, Falk, Paasch, Uwe, and Schuppe, Hans-Christian

Published
2007

26. Andrology

Author

Glander, Hans-Jürgen, Haidl, Gerhard, Köhn, Frank-Michael, Ochsendorf, Falk, Paasch, Uwe, and Schuppe, Hans-Christian

Published
2007

32. Genetisch bedingte Störungen der Spermiogenese

Author

Schill, Wolf-Bernhard, Haidl, Gerhard, Braun-Falco, O., editor, Petzoldt, D., editor, Schnyder, U. W., editor, Wolff, K., editor, Burg, G., editor, Christophers, E., editor, Happle, R., editor, Orfanos, C. E., editor, Plewig, G., editor, Schöpft, E., editor, Marghescu, Sandor, editor, Lubach, Dietrich, editor, and Neumann, Christine, editor

Published
1991
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33. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Author

Agarwal, Ashok, Parekh, Neel, Selvam, Manesh Kumar Panner, Henkel, Ralf, Shah, Rupin, Homa, Sheryl T., Ramasamy, Ranjith, Ko, Edmund, Tremellen, Kelton, Esteves, Sandro, Majzoub, Ahmad, Alvarez, Juan G., Gardner, David K., Jayasena, Channa N., Ramsay, Jonathan W., Cho, Chak-Lam, Saleh, Ramadan, Sakkas, Denny, Hotaling, James M., Lundy, Scott D., Vij, Sarah, Marmar, Joel, Gosalvez, Jaime, Sabanegh, Edmund, Park, Hyun Jun, Zini, Armand, Kavoussi, Parviz, Micic, Sava, Smith, Ryan, Busetto, Gian Maria, Bakircioglu, Mustafa Emre, Haidl, Gerhard, Balercia, Giancarlo, Garrido Puchalt, Nicols, Ben-Khalifa, Moncef, Tadros, Nicholas, Kirkman-Browne, Jackson, Moskovtsev, Sergey, Huang, Xuefeng, Borges, Edson, Jr., Franken, Daniel, Bar-Chama, Natan, Morimoto, Yoshiharu, Tomita, Kazuhisa, Srini, Vasan Satya, Ombelet, Willem, Baldi, Elisabetta, Muratori, Monica, Yumura, Yasushi, La Vignera, Sandro, Kosgi, Raghavender, Martinez, Marlon P., Evenson, Donald P., Zylbersztejn, Daniel Suslik, Roque, Matheus, Cocuzza, Marcello, Vieira, Marcelo, Ben-Meir, Assaf, Orvieto, Raoul, Levitas, Eliahu, Wiser, Amir, Arafa, Mohamed, Malhotra, Vineet, Parekattil, Sijo Joseph, Elbardisi, Haitham, Carvalho, Luiz, Dada, Rima, Sifer, Christophe, Talwar, Pankaj, Gudeloglu, Ahmet, Mahmoud, Ahmed M. A., Terras, Khaled, Yazbeck, Chadi, Nebojsa, Bojanic, Durairajanayagam, Damayanthi, Mounir, Ajina, Kahn, Linda G., Baskaran, Saradha, Pai, Rishma Dhillon, Paoli, Donatella, Leisegang, Kristian, Moein, Mohamed-Reza, Malik, Sonia, Yaman, Onder, Samanta, Luna, Bayane, Fouad, Jindal, Sunil K., Kendirci, Muammer, Altay, Baris, Perovic, Dragoljub, Harlev, Avi, and Ege Üniversitesi

Subjects
Oxidative stress, Semen, Oxidation reduction potential, MOSI, Infertility, male
Abstract

WOS: 000482196700006, PubMed ID: 31081299, Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause., American Center for Reproductive Medicine, Financial support for this study was provided by the American Center for Reproductive Medicine.

Published
2019

37. Therapeutic options in male genital tract inflammation

Author

Haidl, Gerhard, Haidl, Friederike, Allam, Jean-Pierre, Schuppe, Hans-Christian, Haidl, Gerhard, Haidl, Friederike, Allam, Jean-Pierre, and Schuppe, Hans-Christian

Abstract

Chronic inflammatory conditions of the genital tract are still unsatisfactorily recognised in the workup of male infertility due to inappropriate definitions and inconsistent diagnostic criteria. The most popular term used for description of both, infections and inflammation in the genital tract is MAGI (male accessory gland infection). In asymptomatic patients, the diagnosis is primarily based on leucocytospermia (i.e., more than 1 million peroxidase-positive leucocytes per ml ejaculate), although ongoing infections should be identified and distinguished from post-infectious or non-infectious inflammatory disease. In addition to alterations of the basic semen parameters, sperm functions -and DNA integrity may be affected by chronic inflammation of the male genital tract. Despite considerable diagnostic drawbacks and a rather limited database concerning evidence-based therapy, adequate management of affected patients appears mandatory. Antibiotic treatment aims at the eradication or reduction of pathogenic bacteria in the ejaculate. Available studies suggest, that NSAID are effective in chronic inflammatory conditions. Moreover, low-dose corticosteroids, mast cell blockers, and other immune-modulatory compounds as well as a sequential adjuvant treatment with antioxidants can be considered as therapeutic options.

Published
2019

39. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Author

Agarwal, Ashok, primary, Parekh, Neel, additional, Panner Selvam, Manesh Kumar, additional, Henkel, Ralf, additional, Shah, Rupin, additional, Homa, Sheryl T., additional, Ramasamy, Ranjith, additional, Ko, Edmund, additional, Tremellen, Kelton, additional, Esteves, Sandro, additional, Majzoub, Ahmad, additional, Alvarez, Juan G., additional, Gardner, David K., additional, Jayasena, Channa N., additional, Ramsay, Jonathan W., additional, Cho, Chak-Lam, additional, Saleh, Ramadan, additional, Sakkas, Denny, additional, Hotaling, James M., additional, Lundy, Scott D., additional, Vij, Sarah, additional, Marmar, Joel, additional, Gosalvez, Jaime, additional, Sabanegh, Edmund, additional, Park, Hyun Jun, additional, Zini, Armand, additional, Kavoussi, Parviz, additional, Micic, Sava, additional, Smith, Ryan, additional, Busetto, Gian Maria, additional, Bakırcıoğlu, Mustafa Emre, additional, Haidl, Gerhard, additional, Balercia, Giancarlo, additional, Puchalt, Nicolás Garrido, additional, Ben-Khalifa, Moncef, additional, Tadros, Nicholas, additional, Kirkman-Browne, Jackson, additional, Moskovtsev, Sergey, additional, Huang, Xuefeng, additional, Borges, Edson, additional, Franken, Daniel, additional, Bar-Chama, Natan, additional, Morimoto, Yoshiharu, additional, Tomita, Kazuhisa, additional, Srini, Vasan Satya, additional, Ombelet, Willem, additional, Baldi, Elisabetta, additional, Muratori, Monica, additional, Yumura, Yasushi, additional, La Vignera, Sandro, additional, Kosgi, Raghavender, additional, Martinez, Marlon P., additional, Evenson, Donald P., additional, Zylbersztejn, Daniel Suslik, additional, Roque, Matheus, additional, Cocuzza, Marcello, additional, Vieira, Marcelo, additional, Ben-Meir, Assaf, additional, Orvieto, Raoul, additional, Levitas, Eliahu, additional, Wiser, Amir, additional, Arafa, Mohamed, additional, Malhotra, Vineet, additional, Parekattil, Sijo Joseph, additional, Elbardisi, Haitham, additional, Carvalho, Luiz, additional, Dada, Rima, additional, Sifer, Christophe, additional, Talwar, Pankaj, additional, Gudeloglu, Ahmet, additional, Mahmoud, Ahmed M.A., additional, Terras, Khaled, additional, Yazbeck, Chadi, additional, Nebojsa, Bojanic, additional, Durairajanayagam, Damayanthi, additional, Mounir, Ajina, additional, Kahn, Linda G., additional, Baskaran, Saradha, additional, Pai, Rishma Dhillon, additional, Paoli, Donatella, additional, Leisegang, Kristian, additional, Moein, Mohamed-Reza, additional, Malik, Sonia, additional, Yaman, Onder, additional, Samanta, Luna, additional, Bayane, Fouad, additional, Jindal, Sunil K., additional, Kendirci, Muammer, additional, Altay, Baris, additional, Perovic, Dragoljub, additional, and Harlev, Avi, additional

Published
2019
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