1. Outbreak of central nervous system infections among children in Thai Binh, Viet Nam
- Author
-
Duc Long Phi, Xuan Duong Tran, Minh Manh To, Hai Yen Dang, Thi Dung Pham, Thi Thu Trang Vu, Trong Kiem Tran, Manh Dung Do, Thi Thuy Vu, Stéphane Ranque, Laetitia Ninove, Sylvie Pillet, Philippe Colson, Bernard La Scola, Van Thuan Hoang, and Philippe Gautret
- Subjects
Central nervous system ,meningitis ,children ,enterovirus ,Thai Binh ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
From July to October 2020, 99 cases of central nervous system (CNS) infections were identified in Thai Binh Pediatric Hospital, Viet Nam, representing a five-fold increase compared to the baseline incidence during the previous five years. Clinical data were retrospectively collected. Cerebrospinal fluid specimens (CSF) were secondarily tested for pathogens using viral culture and PCR assays. Patient median age was 5 years (0–12 years); 58.6% were male. Of these children, 83.8% had CSF white blood culture (WBC) counts of ≥ 10 cells/µL, including 58 of 99 (58.6%) with a WBC count ≥ 100 cells/µL. Overall, 72 (72.7%) patients had confirmed infections with a pathogen identified in the CSF, the majority of which (66) were enterovirus. Sequencing results suggested that the rise of incidence observed in 2020 was due to Echovirus 4 (n = 45), Echovirus 30 (n = 8), and Echovirus 6 (n = 1) circulation. A confirmed CNS infection was significantly associated with older age (≥5 years, OR = 3.64, p = 0.03) and with an increased WBC count in the CSF (OR = 6.38, p-value = 0.01 for WBCs from 10 to
- Published
- 2022
- Full Text
- View/download PDF