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577 results on '"Hague, William"'

1. The role of secret intelligence in British foreign policy

Author

Hague, William

Subjects
INTELLIGENCE - Great Britain, GREAT BRITAIN - Foreign Policy, SECURITY, NATIONAL - Great Britain
Abstract

por, As spoken by William Hague, MP, at a briefing at the Foreign & Commonwealth Office

Published
2011

2. Cost-effectiveness of diagnosis and treatment of early gestational diabetes mellitus: economic evaluation of the TOBOGM study, an international multicenter randomized controlled trial

Author

Haque, Mohammad M., Tannous, W. Kathy, Herman, William H., Immanuel, Jincy, Hague, William M., Teede, Helena, Enticott, Joanne, Cheung, N. Wah, Hibbert, Emily, Nolan, Christopher J., Peek, Michael J., Wong, Vincent W., Flack, Jeff R., Mclean, Mark, Sweeting, Arianne, Gianatti, Emily, Kautzky-Willer, Alexandra, Jürgen Harreiter, Mohan, Viswanathan, Backman, Helena, and Simmons, David

Published
2024
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4. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, Caroline, Seed, Paul T, Sklavounos, Alexandros, Geenes, Victoria, Di Illio, Chiara, Chambers, Jenny, Kohari, Katherine, Bacq, Yannick, Bozkurt, Nuray, Brun-Furrer, Romana, Bull, Laura, Estiú, Maria C, Grymowicz, Monika, Gunaydin, Berrin, Hague, William M, Haslinger, Christian, Hu, Yayi, Kawakita, Tetsuya, Kebapcilar, Ayse G, Kebapcilar, Levent, Kondrackienė, Jūratė, Koster, Maria PH, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Locatelli, Anna, Macias, Rocio IR, Marschall, Hanns-Ulrich, Oudijk, Martijn A, Raz, Yael, Rimon, Eli, Shan, Dan, Shao, Yong, Tribe, Rachel, Tripodi, Valeria, Abide, Cigdem Yayla, Yenidede, Ilter, Thornton, Jim G, Chappell, Lucy C, and Williamson, Catherine

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Digestive Diseases, Reproductive health and childbirth, Good Health and Well Being, Alanine Transaminase, Aspartate Aminotransferases, Bile Acids and Salts, Bilirubin, Biomarkers, Case-Control Studies, Cholestasis, Intrahepatic, Cohort Studies, Female, Humans, Infant, Newborn, Perinatal Death, Pregnancy, Pregnancy Complications, Premature Birth, ROC Curve, Randomized Controlled Trials as Topic, Risk Factors, Stillbirth, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundIntrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth.MethodsWe did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and population-based studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logistic and stepwise logistic regression. This study is registered with PROSPERO, number CRD42017069134.FindingsWe assessed 109 full-text articles, of which 23 studies were eligible for the aggregate data meta-analysis (5557 intrahepatic cholestasis of pregnancy cases and 165 136 controls), and 27 provided IPD (5269 intrahepatic cholestasis of pregnancy cases). Stillbirth occurred in 45 (0·83%) of 4936 intrahepatic cholestasis of pregnancy cases and 519 (0·32%) of 163 947 control pregnancies (odds ratio [OR] 1·46 [95% CI 0·73-2·89]; I2=59·8%). In singleton pregnancies, stillbirth was associated with maximum total bile acid concentration (area under the receiver operating characteristic curve [ROC AUC]) 0·83 [95% CI 0·74-0·92]), but not alanine aminotransferase (ROC AUC 0·46 [0·35-0·57]). For singleton pregnancies, the prevalence of stillbirth was three (0·13%; 95% CI 0·02-0·38) of 2310 intrahepatic cholestasis of pregnancy cases in women with serum total bile acids of less than 40 μmol/L versus four (0·28%; 0·08-0·72) of 1412 cases with total bile acids of 40-99 μmol/L (hazard ratio [HR] 2·35 [95% CI 0·52-10·50]; p=0·26), and versus 18 (3·44%; 2·05-5·37) of 524 cases for bile acids of 100 μmol/L or more (HR 30·50 [8·83-105·30]; p

Published
2019

5. GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Author

Dixon, Peter H., Levine, Adam P., Cebola, Inês, Chan, Melanie M. Y., Amin, Aliya S., Aich, Anshul, Mozere, Monika, Maude, Hannah, Mitchell, Alice L., Zhang, Jun, Chambers, Jenny, Syngelaki, Argyro, Donnelly, Jennifer, Cooley, Sharon, Geary, Michael, Nicolaides, Kypros, Thorsell, Malin, Hague, William M., Estiu, Maria Cecilia, Marschall, Hanns-Ulrich, Gale, Daniel P., and Williamson, Catherine

Published
2022
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6. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

Author

Ovadia, Caroline, Sajous, Jenna, Seed, Paul T, Patel, Kajol, Williamson, Nicholas J, Attilakos, George, Azzaroli, Francesco, Bacq, Yannick, Batsry, Linoy, Broom, Kelsey, Brun-Furrer, Romana, Bull, Laura, Chambers, Jenny, Cui, Yue, Ding, Min, Dixon, Peter H, Estiú, Maria C, Gardiner, Fergus W, Geenes, Victoria, Grymowicz, Monika, Günaydin, Berrin, Hague, William M, Haslinger, Christian, Hu, Yayi, Indraccolo, Ugo, Juusela, Alexander, Kane, Stefan C, Kebapcilar, Ayse, Kebapcilar, Levent, Kohari, Katherine, Kondrackienė, Jūratė, Koster, Maria P H, Lee, Richard H, Liu, Xiaohua, Locatelli, Anna, Macias, Rocio I R, Madazli, Riza, Majewska, Agata, Maksym, Kasia, Marathe, Jessica A, Morton, Adam, Oudijk, Martijn A, Öztekin, Deniz, Peek, Michael J, Shennan, Andrew H, Tribe, Rachel M, Tripodi, Valeria, Türk Özterlemez, Naciye, Vasavan, Tharni, Wong, L F Audris, Yinon, Yoav, Zhang, Qianwen, Zloto, Keren, Marschall, Hanns-Ulrich, Thornton, Jim, Chappell, Lucy C, and Williamson, Catherine

Published
2021
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7. Relationship Between Early-Pregnancy Glycemia and Adverse Outcomes : Findings From the TOBOGM Study

Author

Sweeting, Arianne, Enticott, Joanne, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Mohan, Viswanathan, Cheung, N. Wah, Simmons, David, Sweeting, Arianne, Enticott, Joanne, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Mohan, Viswanathan, Cheung, N. Wah, and Simmons, David

Abstract

OBJECTIVE: We evaluated associations between early-pregnancy oral glucose tolerance test (OGTT) glucose and complications in the Treatment of Booking Gestational Diabetes Mellitus (TOBOGM) cohort to inform prognostic OGTT thresholds. RESEARCH DESIGN AND METHODS: Individuals with risk factors for hyperglycemia were recruited for an international, multicenter, randomized controlled gestational diabetes mellitus (GDM) (World Health Organization 2013 criteria) treatment trial. A 2-h 75-g OGTT was performed at <20 weeks' gestation. Individuals with early treated hyperglycemia in pregnancy were excluded from the primary analysis. Early OGTT glucose concentrations were analyzed continuously and in glycemic categories (normal, low band, and high band). RESULTS: Overall, 3,645 individuals had an OGTT at (mean ± SD) 15.6 ± 2.5 weeks. For each 1-SD increase in fasting, 1-h, and 2-h glucose values, there were continuous positive associations with late GDM: adjusted odds ratio (aOR) 2.04 (95% CI 1.82-2.27), 3.05 (2.72-3.43), and 2.21 (1.99-2.45), respectively. There were continuous positive associations between 1-h and 2-h glucose and the perinatal composite (birth <37 + 0 weeks, birth trauma, birth weight ≥4,500 g, respiratory distress, phototherapy requirement, stillbirth/neonatal death, and shoulder dystocia), with aOR 1.15 (95% CI 1.04-1.26) and 1.14 (1.04-1.25), respectively, and with large-for-gestational-age offspring, with aOR 1.18 (1.06-1.31) and 1.26 (1.01-1.25), respectively. Significant associations were also observed between 1-h glucose and cesarean section and between fasting and 2-h glucose and neonatal hypoglycemia. In categorical analysis, only the high-band 1-h glucose (≥10.6 mmol/L [191 mg/dL]) predicted the perinatal composite. CONCLUSIONS: There is a continuous positive association between early-pregnancy OGTT glucose and complications. In individuals with hyperglycemia risk factors, only the high-glycemic-band 1-h glucose corresponded to increased ris, Funding: This study was supported by grantsfrom the National Health and Medical Research Council (grants 1104231 and 2009326), the Region Örebro Research Committee (grants Dnr OLL-970566 and OLL-942177), Medical Scientific Fund of the Mayor of Vienna (project 15205), the South Western Sydney Local Health District Academic Unit (grant 2016), and a Western Sydney University Ainsworth Trust Grant (2019)

Published
2024
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8. Effect of treatment for early gestational diabetes mellitus on neonatal respiratory distress : A secondary analysis of the TOBOGM study

Author

Simmons, David, Immanuel, Jincy, Hague, William M., Coat, Suzette, Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Cheung, N. Wah, TOBOGM Research Group, Simmons, David, Immanuel, Jincy, Hague, William M., Coat, Suzette, Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Cheung, N. Wah, and TOBOGM Research Group

Abstract

OBJECTIVE: To identify factors associated with neonatal respiratory distress (NRD) in early Gestational diabetes mellitus (eGDM). DESIGN: Nested case-control analysis of the TOBOGM trial. SETTING: Seventeen hospitals: Australia, Sweden, Austria and India. POPULATION: Pregnant women, <20 weeks' gestation, singleton, GDM risk factors. METHODS: Women with GDM risk factors completed an oral glucose tolerance test (OGTT) before 20 weeks: those with eGDM (WHO-2013 criteria) were randomised to immediate or deferred GDM treatment. Logistic regression compared pregnancies with/without NRD, and in pregnancies with NRD, those with/without high-dependency nursery admission for ≤24 h with those admitted for >24 h. Comparisons were adjusted for age, pre-pregnancy body mass index, ethnicity, smoking, primigravity, education and site. Adjusted odds ratios (95% CI) are reported. MAIN OUTCOME MEASURES: NRD definition: ≥4 h of respiratory support (supplemental oxygen or supported ventilation) postpartum. Respiratory distress syndrome (RDS): Supported ventilation and ≥24 h nursery stay. RESULTS: Ninety-nine (12.5%) of 793 infants had NRD; incidence halved (0.50, 0.31-0.79) if GDM treatment was started early. NRD was associated with Caesarean section (2.31, 1.42-3.76), large for gestational age (LGA) (1.83, 1.09-3.08) and shorter gestation (0.95, 0.93-0.97 per day longer). Among NRD infants, >24 h nursery-stay was associated with higher OGTT 1-h glucose (1.38, 1.08-1.76 per mmol/L). Fifteen (2.0%) infants had RDS. CONCLUSIONS: Identifying and treating eGDM reduces NRD risk. NRD is more likely with Caesarean section, LGA and shorter gestation. Further studies are needed to understand the mechanisms behind this eGDM complication and any long-term effects., This study is supported by the National Health and Medical Research Council (NHMRC grants 1104231 and 2009326), the Region Örebro Research Committee (grants Dnr OLL-970566 and OLL-942177), Medical Scientific Fund of the Mayor of Vienna (project numbers 15205 and 23026), the South Western Sydney Local Health District Academic Unit (grant 2016) and a Western Sydney University Ainsworth Trust Grant (2019).

Published
2024
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9. Association Between Immediate Treatment of Early Gestational Diabetes Mellitus and Breastfeeding Outcomes : Findings From the TOBOGM Study

Author

Seifu, Canaan Negash, Immanuel, Jincy, Hague, William M, Teede, Helena, Cheung, N Wah, Hibbert, Emily J, Nolan, Christopher J, Peek, Michael J, Wong, Vincent W, Flack, Jeff R, Mclean, Mark, Sweeting, Arianne, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Gianatti, Emily, Mohan, Viswanathan, Backman, Helena, Simmons, David, Seifu, Canaan Negash, Immanuel, Jincy, Hague, William M, Teede, Helena, Cheung, N Wah, Hibbert, Emily J, Nolan, Christopher J, Peek, Michael J, Wong, Vincent W, Flack, Jeff R, Mclean, Mark, Sweeting, Arianne, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Gianatti, Emily, Mohan, Viswanathan, Backman, Helena, and Simmons, David

Published
2024
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10. Perinatal Outcomes in Early and Late Gestational Diabetes Mellitus After Treatment From 24-28 Weeks' Gestation : A TOBOGM Secondary Analysis

Author

Simmons, David, Immanuel, Jincy, Hague, William M, Teede, Helena, Nolan, Christopher J, Peek, Michael J, Flack, Jeff R, McLean, Mark, Wong, Vincent, Hibbert, Emily J, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Cheung, N Wah, Simmons, David, Immanuel, Jincy, Hague, William M, Teede, Helena, Nolan, Christopher J, Peek, Michael J, Flack, Jeff R, McLean, Mark, Wong, Vincent, Hibbert, Emily J, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, and Cheung, N Wah

Abstract

OBJECTIVE: In most gestational diabetes mellitus (GDM) studies, cohorts have included women combined into study populations without regard to whether hyperglycemia was present earlier in pregnancy. In this study we sought to compare perinatal outcomes between groups: women with early GDM (EGDM group: diagnosis before 20 weeks but no treatment until 24-28 weeks if GDM still present), with late GDM (LGDM group: present only at 24-28 weeks), and with normoglycemia at 24-28 weeks (control subjects). RESEARCH DESIGN AND METHODS: This is a secondary analysis of a randomized controlled treatment trial where we studied, among women with risk factors, early (<20 weeks' gestation) GDM defined according to World Health Organization 2013 criteria. Those receiving early treatment for GDM treatment were excluded. GDM was treated if present at 24-28 weeks. The primary outcome was a composite of birth before 37 weeks' gestation, birth weight ≥4,500 g, birth trauma, neonatal respiratory distress, phototherapy, stillbirth/neonatal death, and shoulder dystocia. Comparisons included adjustment for age, ethnicity, BMI, site, smoking, primigravity, and education. RESULTS: Women with EGDM (n = 254) and LGDM (n = 467) had shorter pregnancy duration than control subjects (n = 2,339). BMI was lowest with LGDM. The composite was increased with EGDM (odds ratio [OR] 1.59, 95% CI 1.18-2.12)) but not LGDM (OR 1.19, 95% CI 0.94-1.50). Induction of labor was higher in both GDM groups. In comparisons with control subjects there were higher birth centile, higher preterm birth rate, and higher rate of neonatal jaundice for the EGDM group (but not the LGDM group). The greatest need for insulin and/or metformin was with EGDM. CONCLUSIONS: Adverse perinatal outcomes were increased with EGDM despite treatment from 24-28 weeks' gestation, suggesting the need to initiate treatment early, and more aggressively, to reduce the effects of exposure to the more severe maternal hyperglycemia from early pregnan

Published
2024
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11. Regression From Early GDM to Normal Glucose Tolerance and Adverse Pregnancy Outcomes in the Treatment of Booking Gestational Diabetes Mellitus Study

Author

Simmons, David, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Cheung, N. Wah, Simmons, David, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent W., Hibbert, Emily J., Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, and Cheung, N. Wah

Abstract

OBJECTIVE: To compare pregnancy outcomes among women with a normal oral glucose tolerance test (OGTT) before 20 weeks' gestation (early) and at 24-28 weeks' gestation (late) (no gestational diabetes mellitus, or No-GDM), those with early GDM randomized to observation with a subsequent normal OGTT (GDM-Regression), and those with GDM on both occasions (GDM-Maintained). RESEARCH DESIGN AND METHODS: Women at <20 weeks' gestation with GDM risk factors who were recruited for a randomized controlled early GDM treatment trial were included. Women with treated early GDM and late GDM (according to the World Health Organization's 2013 criteria) were excluded from this analysis. Logistic regression compared pregnancy outcomes. RESULTS: GDM-Regression (n = 121) group risk factor profiles and OGTT results generally fell between the No-GDM (n = 2,218) and GDM-Maintained (n = 254) groups, with adjusted incidences of pregnancy complications similar between the GDM-Regression and No-GDM groups. CONCLUSIONS: Women with early GDM but normal OGTT at 24-28 weeks' gestation had pregnancy outcomes that were similar to those of individuals without GDM. Identifying early GDM likely to regress would allow treatment to be avoided., Funding:The National Health and Medical Research Council (NHMRC) (grants 1104231 and 2009326)The Region Örebro Research Committee (grants Dnr OLL-970566 and OLL-942177)The Medical Scientific Fund of the Mayor of Vienna (project numbers 15205 and 23026)The South Western Sydney Local Health District Academic Unit (grant 2016)Western Sydney University Ainsworth Trust grant (2019)

Published
2024
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13. Perinatal Outcomes in Early and Late Gestational Diabetes Mellitus After Treatment from 24-28 weeks’ Gestation: A TOBOGM Secondary Analysis

Author

Simmons, David, primary, Immanuel, Jincy, primary, Hague, William M, primary, Teede, Helena, primary, Nolan, Christopher J., primary, J Peek, Michael, primary, R Flack, Jeff, primary, McLean, Mark, primary, Wong, Vincent, primary, J Hibbert, Emily, primary, Kautzky-Willer, Alexandra, primary, Harreiter, Jürgen, primary, Backman, Helena, primary, Gianatti, Emily, primary, Sweeting, Arianne, primary, Mohan, Viswanathan, primary, and Wah Cheung, N, primary

Published
2024
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14. A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial

Author

Hague, William M., Callaway, Leonie, Chambers, Jennifer, Chappell, Lucy, Coat, Suzette, de Haan-Jebbink, Jiska, Dekker, Marloes, Dixon, Peter, Dodd, Jodie, Fuller, Maria, Gordijn, Sanne, Graham, Dorothy, Heikinheimo, Oskari, Hennessy, Annemarie, Kaaja, Risto, Khong, Teck Yee, Lampio, Laura, Louise, Jennie, Makris, Angela, Markus, Corey, Marschall, Hanns-Ulrich, Middleton, Philippa, Mol, Ben W., Morris, Jonathan, Newnham, John P., Ovadia, Caroline, Peek, Michael, Shand, Antonia, Stark, Michael, Thornton, Jim, Timonen, Susanna, Walker, Susan, Warrilow, David, and Williamson, Catherine

Published
2021
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16. The relationship between body mass index and sleep in women with risk factors for gestational diabetes mellitus

Author

Reyes, Pamela Acosta, primary, Immanuel, Jincy, additional, Hague, William M., additional, Teede, Helena, additional, Hibbert, Emily, additional, Nolan, Christopher J., additional, Peek, Michael J., additional, Wong, Vincent, additional, Flack, Jeffrey R., additional, McLean, Mark, additional, Dalal, Raiyomand, additional, Harreiter, Jürgen, additional, Kautzky–Willer, Alexandra, additional, Rajagopal, Rohit, additional, Sweeting, Arianne, additional, Ross, Glynis P., additional, Cheung, Ngai Wah, additional, and Simmons, David, additional

Published
2023
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18. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy

Author

Simmons, David, primary, Immanuel, Jincy, additional, Hague, William M., additional, Teede, Helena, additional, Nolan, Christopher J., additional, Peek, Michael J., additional, Flack, Jeff R., additional, McLean, Mark, additional, Wong, Vincent, additional, Hibbert, Emily, additional, Kautzky-Willer, Alexandra, additional, Harreiter, Jürgen, additional, Backman, Helena, additional, Gianatti, Emily, additional, Sweeting, Arianne, additional, Mohan, Viswanathan, additional, Enticott, Joanne, additional, and Cheung, N. Wah, additional

Published
2023
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21. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy

Author

Simmons, David, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent, Hibbert, Emily, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Enticott, Joanne, Cheung, N. Wah, Simmons, David, Immanuel, Jincy, Hague, William M., Teede, Helena, Nolan, Christopher J., Peek, Michael J., Flack, Jeff R., McLean, Mark, Wong, Vincent, Hibbert, Emily, Kautzky-Willer, Alexandra, Harreiter, Jürgen, Backman, Helena, Gianatti, Emily, Sweeting, Arianne, Mohan, Viswanathan, Enticott, Joanne, and Cheung, N. Wah

Abstract

BACKGROUND: Whether treatment of gestational diabetes before 20 weeks' gestation improves maternal and infant health is unclear. METHODS: We randomly assigned, in a 1:1 ratio, women between 4 weeks' and 19 weeks 6 days' gestation who had a risk factor for hyperglycemia and a diagnosis of gestational diabetes (World Health Organization 2013 criteria) to receive immediate treatment for gestational diabetes or deferred or no treatment, depending on the results of a repeat oral glucose-tolerance test [OGTT] at 24 to 28 weeks' gestation (control). The trial included three primary outcomes: a composite of adverse neonatal outcomes (birth at <37 weeks' gestation, birth trauma, birth weight of ≥4500 g, respiratory distress, phototherapy, stillbirth or neonatal death, or shoulder dystocia), pregnancy-related hypertension (preeclampsia, eclampsia, or gestational hypertension), and neonatal lean body mass. RESULTS: A total of 802 women underwent randomization; 406 were assigned to the immediate-treatment group and 396 to the control group; follow-up data were available for 793 women (98.9%). An initial OGTT was performed at a mean (±SD) gestation of 15.6±2.5 weeks. An adverse neonatal outcome event occurred in 94 of 378 women (24.9%) in the immediate-treatment group and in 113 of 370 women (30.5%) in the control group (adjusted risk difference, -5.6 percentage points; 95% confidence interval [CI], -10.1 to -1.2). Pregnancy-related hypertension occurred in 40 of 378 women (10.6%) in the immediate-treatment group and in 37 of 372 women (9.9%) in the control group (adjusted risk difference, 0.7 percentage points; 95% CI, -1.6 to 2.9). The mean neonatal lean body mass was 2.86 g in the immediate-treatment group and 2.91 g in the control group (adjusted mean difference, -0.04 g; 95% CI, -0.09 to 0.02). No between-group differences were observed with respect to serious adverse events associated with screening and treatment. CONCLUSIONS: Immediate treatment of gestational diabetes

Published
2023
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22. Neonatal Outcomes in Early and Incident Gestational Diabetes Mellitus : Are They Normalized with Treatment from 24–28 Weeks’ Gestation?

Author

SIMMONS, DAVID, IMMANUEL, JINCY, WAH CHEUNG, N., HAGUE, WILLIAM, TEEDE, HELENA, NOLAN, CHRISTOPHER J., Backman, Helena, HIBBERT, EMILY, PEEK, MICHAEL J., MCLEAN, MARK, SWEETING, ARIANNE, MOHAN, VISWANATHAN, HARREITER, JÜRGEN, SIMMONS, DAVID, IMMANUEL, JINCY, WAH CHEUNG, N., HAGUE, WILLIAM, TEEDE, HELENA, NOLAN, CHRISTOPHER J., Backman, Helena, HIBBERT, EMILY, PEEK, MICHAEL J., MCLEAN, MARK, SWEETING, ARIANNE, MOHAN, VISWANATHAN, and HARREITER, JÜRGEN

Published
2023
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23. Effect of High Dose Folic Acid Supplementation in Pregnancy on Pre-eclampsia (FACT): Double Blind, Phase III, Randomised Controlled, International, Multicentre Trial

Author

Wen, Shi Wu, White, Ruth Rennicks, Rybak, Natalie, Gaudet, Laura M., Robson, Stephen, Hague, William, Simms-Stewart, Donnette, Carroli, Guillermo, Smith, Graeme, Fraser, William D., Wells, George, Davidge, Sandra T., Kingdom, John, Coyle, Doug, Fergusson, Dean, Corsi, Daniel J., Champagne, Josee, Sabri, Elham, Ramsay, Tim, Mol, Ben Willem J., Oudijk, Martijn A., and Walker, Mark C.

Published
2019
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25. Intrahepatic cholestasis of pregnancy – Diagnosis and management: A consensus statement of the Society of Obstetric Medicine of Australia and New Zealand (SOMANZ): Executive summary.

Author

Hague, William M., Briley, Annette, Callaway, Leonie, Dekker Nitert, Marloes, Gehlert, Jessica, Graham, Dorothy, Grzeskowiak, Luke, Makris, Angela, Markus, Corey, Middleton, Philippa, Peek, Michael J., Shand, Antonia, Stark, Michael, and Waugh, Jason

Subjects
*MATERNAL health services, *CONSENSUS (Social sciences), *CHOLESTASIS, *PREMATURE infants, *OBSTETRICS, *PERINATAL death, *RISK assessment, *BILE acids, *URINALYSIS, *RIFAMPIN, *BLOOD, *DISEASE complications, *PREGNANCY
Abstract

KEY POINTS: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy liver disease, characterised by pruritus and increased total serum bile acids (TSBA), Australian incidence 0.6–0.7%.ICP is diagnosed by non‐fasting TSBA ≥19 μmol/L in a pregnant woman with pruritus without rash without a known pre‐existing liver disorder.Peak TSBA ≥40 and ≥100 μmol/L identify severe and very severe disease respectively, associated with spontaneous preterm birth when severe, and with stillbirth, when very severe.Benefit‐vs‐risk for iatrogenic preterm birth in ICP remains uncertain.Ursodeoxycholic acid remains the best pharmacotherapy preterm, improving perinatal outcome and reducing pruritus, although it has not been shown to reduce stillbirth. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial

Author

Rodger, Marc A, Hague, William M, Kingdom, John, Kahn, Susan R, Karovitch, Alan, Sermer, Mathew, Clement, Anne Marie, Coat, Suzette, Chan, Wee Shian, Said, Joanne, Rey, Evelyne, Robinson, Sue, Khurana, Rshmi, Demers, Christine, Kovacs, Michael J, Solymoss, Susan, Hinshaw, Kim, Dwyer, James, Smith, Graeme, McDonald, Sarah, Newstead-Angel, Jill, McLeod, Anne, Khandelwal, Meena, Silver, Robert M, Le Gal, Gregoire, Greer, Ian A, Keely, Erin, Rosene-Montella, Karen, Walker, Mark, and Wells, Philip S

Published
2014
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33. Infant Exposure to Armodafinil Through Human Milk Following Maternal Use of Modafinil.

Author

Leggett, Catherine, Ritchie, Usha, Costi, Lynn, Elliot, David, Mangoni, Arduino A, and Hague, William M.

Abstract

Introduction: Narcolepsy, a condition adversely affecting psychological, social, and cognitive function, is more prevalent in females of childbearing age than the general population. Modafinil and armodafinil are central nervous system stimulants approved for treatment of narcolepsy. Infant exposure to these agents through human milk has not been investigated. Poor quality medication safety information during lactation is associated with early cessation of breastfeeding and suboptimal healthcare for the breastfeeding family. Main Issue: In this case study, we measured the concentration of armodafinil (the most active form of modafinil) in human milk and infant plasma to quantify infant exposure. Management: The participant was a 30-year-old primipara with narcolepsy, taking modafinil (300 mg morning, 100 mg noon) while breastfeeding her 6-week-old infant despite the paucity of safety information. Armodafinil concentrations were measured in eight serial human milk samples collected over a 26-hr period and in single maternal and infant plasma samples using ultra performance liquid chromatography - tandem mass spectrometry. The average concentration of armodafinil in human milk was 1.96 mg/L; the relative infant dose was 4.85%; the theoretical infant dose was 0.294 mg/kg/day. Maternal and infant plasma concentrations of armodafinil were 12.02 mg/L and 0.19 mg/L, respectively. The participant continued to exclusively breastfeed the infant, who had normal growth and development. Conclusion: Based on these findings, relatively small amounts of armodafinil pass into human milk, with consequent limited infant exposure. Consideration can be given to the use of modafinil or armodafinil during breastfeeding, provided the infant is monitored. Further studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Whole-genome sequencing of patients with rare diseases in a national health system

Author

Turro, Ernest, Astle, William J., Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver S., Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri V.V., Aitman, Timothy J., Bennett, David L., Calleja, Paul, Carss, Keren, Caulfield, Mark J., Chinnery, Patrick F., Dixon, Peter H., Gale, Daniel P., James, Roger, Koziell, Ania, Laffan, Michael A., Levine, Adam P., Maher, Eamonn R., Markus, Hugh S., Morales, Joannella, Morrell, Nicholas W., Mumford, Andrew D., Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi B.A., Saleem, Moin A., Smith, Kenneth G.C., Stark, Hannah, Tan, Rhea Y.Y., Themistocleous, Andreas C., Thrasher, Adrian J., Watkins, Hugh, Webster, Andrew R., Wilkins, Martin R., Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David R., Abbs, Stephen, Abulhoul, Lara, Adlard, Julian, Ahmed, Munaza, Alachkar, Hana, Allsup, David J., Almeida-King, Jeff, Ancliff, Philip, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Ashford, Sofie, Attwood, Anthony, Aurora, Paul, Babbs, Christian, Bacchelli, Chiara, Bakchoul, Tamam, Banka, Siddharth, Bariana, Tadbir, Barwell, Julian, Batista, Joana, Baxendale, Helen E., Beales, Phil L., Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria A.K., Black, Graeme C., Bleda, Marta, Blesneac, Iulia, Bockenhauer, Detlef, Bogaard, Harm, Bourne, Christian J., Boyce, Sara, Bradley, John R., Bragin, Eugene, Breen, Gerome, Brennan, Paul, Brewer, Carole, Brown, Matthew, Browning, Andrew C., Browning, Michael J., Buchan, Rachel J., Buckland, Matthew S., Bueser, Teofila, Diz, Carmen Bugarin, Burn, John, Burns, Siobhan O., Burrows, Nigel, Campbell, Carolyn, Carr-White, Gerald, Casey, Ruth, Chambers, Jenny, Chambers, John, Chan, Melanie M.Y., Cheah, Calvin, Cheng, Floria, Chitre, Manali, Christian, Martin T., Church, Colin, Clayton-Smith, Jill, Cleary, Maureen, Brod, Naomi Clements, Coghlan, Gerry, Colby, Elizabeth, Cole, Trevor R.P., Collins, Janine, Collins, Peter W., Colombo, Camilla, Compton, Cecilia J., Condliffe, Robin, Cook, Stuart, Cook, H. Terence, Cooper, Nichola, Corris, Paul A A., Furnell, Abigail, Cunningham, Fiona, Curry, Nicola S., Cutler, Antony J., Daniels, Matthew J., Dattani, Mehul, Daugherty, Louise C., Davis, John, De Soyza, Anthony, Dent, Timothy, Deshpande, Charu, Dewhurst, Eleanor F., Douzgou, Sofia, Drazyk, Anna M., Drewe, Elizabeth, Duarte, Daniel, Dutt, Tina, Edgar, J. David M., Edwards, Karen, Egner, William, Ekani, Melanie N., Elliott, Perry, Erber, Wendy N., Erwood, Marie, Estiu, Maria C., Evans, Dafydd Gareth, Evans, Gillian, Everington, Tamara, Eyries, Mélanie, Fassihi, Hiva, Favier, Remi, Findhammer, Jack, Fletcher, Debra, Flinter, Frances A., Floto, R. Andres, Fowler, Tom, Fox, James, Frary, Amy J., French, Courtney E., Freson, Kathleen, Gall, Henning, Ganesan, Vijeya, Gattens, Michael, Geoghegan, Claire, Gerighty, Terence S.A., Gharavi, Ali G., Ghio, Stefano, Ghofrani, Hossein Ardeschir, Gibbs, J. Simon R., Gibson, Kate, Gilmour, Kimberly C., Girerd, Barbara, Gleadall, Nicholas S., Goddard, Sarah, Goldstein, David B., Gomez, Keith, Gordins, Pavels, Gosal, David, Graham, Jodie, Grassi, Luigi, Greenhalgh, Lynn, Greinacher, Andreas, Gresele, Paolo, Griffiths, Philip, Grigoriadou, Sofia, Grocock, Russell J., Grozeva, Detelina, Gurnell, Mark, Hackett, Scott, Hadinnapola, Charaka, Hague, William M., Hague, Rosie, Hall, Matthew, Hanson, Helen L., Haque, Eshika, Harkness, Kirsty, Harper, Andrew R., Harris, Claire L L., Hart, Daniel, Hassan, Ahamad, Hayman, Grant, Henderson, Alex, Herwadkar, Archana, Hoffman, Jonathan, Holden, Simon, Horvath, Rita, Houlden, Henry, Houweling, Arjan C C., Howard, Luke S., Hu, Fengyuan, Hudson, Gavin, Hughes, Joseph, Huissoon, Aarnoud P., Humbert, Marc, Hunter, Sarah, Hurles, Matthew, Irving, Melita, Izatt, Louise, Johnson, Sally A., Jolles, Stephen, Jolley, Jennifer, Josifova, Dragana, Jurkute, Neringa, Karten, Tim, Karten, Johannes, Kasanicki, Mary A., Kazkaz, Hanadi, Kazmi, Rashid, Kelleher, Peter, Kelly, Anne M., Kelsall, Wilf, Kempster, Carly, Kiely, David G., Kingston, Nathalie, Klima, Robert, Koelling, Nils, Kostadima, Myrto, Kovacs, Gabor, Kreuzhuber, Roman, Kuijpers, Taco W., Kumar, Ajith, Kumararatne, Dinakantha, Kurian, Manju A., Lalloo, Fiona, Lambert, Michele, Lawrie, Allan, Layton, D. Mark, Lench, Nick, Lentaigne, Claire, Lester, Tracy, Linger, Rachel, Longhurst, Hilary, Lorenzo, Lorena E., Louka, Eleni, Lyons, Paul A., Machado, Rajiv D., MacKenzie Ross, Robert V., Madan, Bella, Maimaris, Jesmeen, Malka, Samantha, Mangles, Sarah, Marchbank, Kevin J., Marks, Stephen, Marschall, Hanns Ulrich, Marshall, Andrew, Martin, Jennifer, Mathias, Mary, Matthews, Emma, Maxwell, Heather, McAlinden, Paul, McCarthy, Mark I., McKinney, Harriet, McMahon, Aoife, Meacham, Stuart, Mead, Adam J., Castello, Ignacio Medina, Mehta, Sarju G G., Michaelides, Michel, Millar, Carolyn, Mohammed, Shehla N., Moledina, Shahin, Montani, David, Moore, Anthony T., Mozere, Monika, Muir, Keith W., Nemeth, Andrea H., Newman, William G., Newnham, Michael, Noorani, Sadia, Nurden, Paquita, O’Sullivan, Jennifer, Obaji, Samya, Odhams, Chris, Okoli, Steven, Olschewski, Andrea, Olschewski, Horst, Ong, Kai Ren, Oram, S. Helen, Ouwehand, Willem H., Palles, Claire, Papadia, Sofia, Park, Soo Mi, Parry, David, Patel, Smita, Paterson, Joan, Peacock, Andrew, Pearce, Simon H H., Peden, John, Peerlinck, Kathelijne, Penkett, Christopher J., Pepke-Zaba, Joanna, Petersen, Romina, Pilkington, Clarissa, Poole, Kenneth E.S., Prathalingam, Radhika, Psaila, Bethan, Pyle, Angela, Quinton, Richard, Rahman, Shamima, Rao, Anupama, Raymond, F. Lucy, Rayner-Matthews, Paula J., Rees, Christine, Renton, Tara, Rhodes, Christopher J., Rice, Andrew S.C., Richter, Alex, Robert, Leema, Rogers, Anthony, Rose, Sarah J., Ross-Russell, Robert, Roughley, Catherine, Roy, Noemi B. A, Ruddy, Deborah M., Sadeghi-Alavijeh, Omid, Samani, Nilesh, Samarghitean, Crina, Sargur, Ravishankar B., Sarkany, Robert N., Satchell, Simon, Savic, Sinisa, Sayer, John A., Sayer, Genevieve, Scelsi, Laura, Schaefer, Andrew M., Schulman, Sol, Scott, Richard, Scully, Marie, Searle, Claire, Seeger, Werner, Sen, Arjune, Sewell, W. A.Carrock, Seyres, Denis, Shah, Neil, Shapiro, Susan E., Shaw, Adam C., Short, Patrick J., Sibson, Keith, Side, Lucy, Simeoni, Ilenia, Simpson, Michael A A., Sims, Matthew C., Sivapalaratnam, Suthesh, Smedley, Damian, Smith, Katherine R., Snape, Katie, Soranzo, Nicole, Soubrier, Florent, Southgate, Laura, Spasic-Boskovic, Olivera, Staines, Simon, Staples, Emily, Steward, Charles, Stirrups, Kathleen E., Stuckey, Alex, Suntharalingam, Jay, Swietlik, Emilia M., Syrris, Petros, Tait, R. Campbell, Talks, Kate, Tate, Katie, Taylor, John M., Taylor, Jenny C., Thaventhiran, James E., Thomas, Ellen, Thomas, David, Thomas, Moira J., Thomas, Patrick, Thomson, Kate, Threadgold, Glen, Tilly, Tobias, Tischkowitz, Marc, Titterton, Catherine, Todd, John A., Toh, Cheng Hock, Tolhuis, Bas, Tomlinson, Ian P., Toshner, Mark, Traylor, Matthew, Treacy, Carmen, Treadaway, Paul, Trembath, Richard, Turek, Wojciech, Twiss, Philip, Vale, Tom, Geet, Chris Van, Zuydam, Natalie van, Vandekuilen, Maarten, Vandersteen, Anthony M., Vazquez-Lopez, Marta, von Ziegenweidt, Julie, Vonk Noordegraaf, Anton, Wagner, Annette, Waisfisz, Quinten, Walker, Suellen M., Walker, Neil, Walter, Klaudia, Ware, James S., Watt, Christopher, Wedderburn, Lucy, Wei, Wei, Welch, Steven B., Wessels, Julie, Westbury, Sarah K., Westwood, John Paul, Wharton, John, Whitehorn, Deborah, Wilkie, Andrew O. M, Wilson, Brian T., Wong, Edwin K.S., Wood, Nicholas, Wood, Yvette, Woods, Christopher Geoffrey, Woodward, Emma R R., Wort, Stephen J., Worth, Austen, Wright, Michael, Yates, Katherine, Yong, Patrick F.K., Young, Timothy, Yu, Ping, Yu-Wai-Man, Patrick, Zlamalova, Eliska, University of Cambridge [UK] (CAM), John Wyeth & Brother Limited, Medical Research Council (MRC), Wellcome Trust, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Human genetics, ACS - Atherosclerosis & ischemic syndromes, Landsteiner Laboratory, Paediatric Infectious Diseases / Rheumatology / Immunology, ARD - Amsterdam Reproduction and Development, and Project, NIHR BioResource for the 100,000 Genomes

Subjects
0301 basic medicine, Erythrocytes, Internationality, Databases, Factual, National Health Programs, [SDV]Life Sciences [q-bio], Disease, VARIANTS, Genome, State Medicine, NIHR BioResource for the 100,000 Genomes Project, 0302 clinical medicine, Medicine, GATA1 Transcription Factor, Genetics, Multidisciplinary, Translational bioinformatics, ASSOCIATION, 3. Good health, Multidisciplinary Sciences, Phenotype, 030220 oncology & carcinogenesis, disease genetics, Medical genetics, Science & Technology - Other Topics, Receptors, Thrombopoietin, medicine.medical_specialty, General Science & Technology, Quantitative Trait Loci, Genomics, Computational biology, Biology, DIAGNOSIS, computational biology and bioinformatics, Actin-Related Protein 2-3 Complex, Article, LRBA, LINKS, 03 medical and health sciences, Rare Diseases, Humans, Alleles, Adaptor Proteins, Signal Transducing, Whole genome sequencing, National health, Science & Technology, Whole Genome Sequencing, MUTATIONS, business.industry, THROMBOCYTOPENIA, United Kingdom, MACROTHROMBOCYTOPENIA, genetics research, 030104 developmental biology, business, Rare disease
Abstract

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. We generated WGS data for 13,037 participants, of whom 9,802 had a rare disease, and provided a genetic diagnosis to 1,138 of the 7,065 extensively phenotyped participants. We identified 95 Mendelian associations between genes and rare diseases, of which 11 have been discovered since 2015 and at least 79 are confirmed to be aetiological. By generating WGS data of UK Biobank participants2, we found that rare alleles can explain the presence of some individuals in the tails of a quantitative trait for red blood cells. Finally, we identified four novel non-coding variants that cause disease through the disruption of transcription of ARPC1B, GATA1, LRBA and MPL. Our study demonstrates a synergy by using WGS for diagnosis and aetiological discovery in routine healthcare.

Published
2021

36. Is There Moral Giftedness?

Author

Hague, William J.

Abstract

Describes higher levels of morality by contrasting Kohlber's Cognitive Developmentalism and Dabrowski's Positive Disintegration. It argues that far from being a gift, high-level morality is a function of the whole person. It is something chosen and striven for, and the result of compassion and some kind of disintegration. (Author/CR)

Published
1998

41. Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis

Author

Ovadia, Caroline, primary, Sajous, Jenna, additional, Seed, Paul T., additional, Patel, Kajol, additional, Williamson, Nicholas J., additional, Attilakos, George, additional, Azzaroli, Francesco, additional, Bacq, Yannick, additional, Batsry, Linoy, additional, Broom, Kelsey, additional, Brun-Furrer, Romana, additional, Bull, Laura, additional, Chambers, Jenny, additional, Cui, Yue, additional, Ding, Min, additional, Dixon, Peter H., additional, Estiú, Maria C., additional, Gardiner, Fergus W., additional, Geenes, Victoria, additional, Grymowicz, Monika, additional, Günaydin, Berrin, additional, Hague, William M., additional, Haslinger, Christian, additional, Hu, Yayi, additional, Indraccolo, Ugo, additional, Juusela, Alexander, additional, Kane, Stefan C., additional, Kebapcilar, Ayse, additional, Kebapcilar, Levent, additional, Kohari, Katherine, additional, Kondrackienė, Jūratė, additional, Koster, Maria P. H., additional, Lee, Richard H., additional, Liu, Xiaohua, additional, Locatelli, Anna, additional, Macias, Rocio I. R., additional, Madazli, Riza, additional, Majewska, Agata, additional, Maksym, Kasia, additional, Marathe, Jessica A., additional, Morton, Adam, additional, Oudijk, Martijn A., additional, Öztekin, Deniz, additional, Peek, Michael J., additional, Shennan, Andrew H., additional, Tribe, Rachel M., additional, Tripodi, Valeria, additional, Özterlemez, Naciye Türk, additional, Vasavan, Tharni, additional, Wong, L. F. Audris, additional, Yinon, Yoav, additional, Zhang, Qianwen, additional, Zloto, Keren, additional, Marschall, Hanns-Ulrich, additional, Thornton, Jim, additional, Chappell, Lucy C., additional, and Williamson, Catherine, additional

Published
2021
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42. Toward a Systemic Explanation of Valuing.

Author

Hague, William J.

Abstract

Examined complexity of valuing by assessing valuing process, beginning with basic method of rank ordering. Participants (n=64) recorded their comments as they completed Rokeach Value Survey. Examination of comments revealed many agendas operating, making valuing far more complex than linear model of rank ordering values permits. Participants' comments revealed systemic rather than only linear tensions among values. (Author/NB)

Published
1993

43. Kohlberg's Legacy: More than Ideas. An Essay Review.

Author

Hague, William J.

Abstract

Reviews "The Kohlberg Legacy for the Helping Professions," by Lisa Kuhmerker, that introduces Kohlberg's research and theory; focuses on its relevance for teachers, religious educators, and counselors; and portrays the man within the theory. Discusses the convergence of Kohlberg's legacy with character and virtue psychology. Contains 33 references. (SV)

Published
1991

45. The BACH project protocol: an international multicentre total Bile Acid Comparison and Harmonisation project and sub-study of the TURRIFIC randomised trial

Author

Markus, Corey, primary, Coat, Suzette, additional, Marschall, Hanns-Ulrich, additional, Williamson, Catherine, additional, Dixon, Peter, additional, Fuller, Maria, additional, Matthews, Susan, additional, Rankin, Wayne, additional, Metz, Michael, additional, and Hague, William M., additional

Published
2021
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46. Cortical plasticity and interneuron recruitment in adolescents born to women with gestational diabetes mellitus

Author

Van Dam, Jago M, Goldsworthy, Mitchell R, Hague, William M, Coat, Suzette, Pitcher, Julia B, Van Dam, Jago M, Goldsworthy, Mitchell R, Hague, William M, Coat, Suzette, and Pitcher, Julia B

Abstract

Exposure to gestational diabetes mellitus (GDM) in utero is associated with a range of adverse cognitive and neurological outcomes. Previously, we reported altered neuroplastic responses to continuous theta burst stimulation (cTBS) in GDM-exposed adolescents. Recent research suggests that the relative excitability of complex oligosynaptic circuits (late I-wave circuits) can predict these responses. We aimed to determine if altered I-wave recruitment was associated with neuroplastic responses in adolescents born to women with GDM. A total of 20 GDM-exposed adolescents and 10 controls (aged 13.1 ± 1.0 years) participated. cTBS was used to induce neuroplasticity. I-wave recruitment was assessed by comparing motor-evoked potential latencies using different TMS coil directions. Recruitment of late I-waves was associated with stronger LTD-like neuroplastic responses to cTBS (p = < 0.001, R2 = 0.36). There were no differences between groups in mean neuroplasticity (p = 0.37), I-wave recruitment (p = 0.87), or the association between these variables (p = 0.41). The relationship between I-wave recruitment and the response to cTBS previously observed in adults is also present in adolescents and does not appear to be altered significantly by in utero GDM exposure. Exposure to GDM does not appear to significantly impair LTD-like synaptic plasticity or interneuron recruitment.

Published
2021

48. Metformin versus Insulin for the treatment of gestational diabetes

Author

Rowan, Janet A., Hague, William M., Gao, Wanzhen, Battin, Malcolm R., and Moore, M. Peter

Subjects
Diabetes in pregnancy -- Drug therapy, Insulin -- Comparative analysis, Insulin -- Complications and side effects, Metformin -- Comparative analysis
Abstract

A study to examine the efficacy of the use of Metformin in the treatment of gestational diabetes as against insulin is conducted. Results conclude that Metformin is a better form of treatment for gestational diabetes rather than insulin as insulin is associated with increased perinatal complications, which Metformin is not.

Published
2008

49. Publisher Correction:Whole-genome sequencing of a sporadic primary immunodeficiency cohort (Nature, (2020), 583, 7814, (90-95), 10.1038/s41586-020-2265-1)

Author

Thaventhiran, James E.D., Lango Allen, Hana, Burren, Oliver S., Rae, William, Greene, Daniel, Staples, Emily, Zhang, Zinan, Farmery, James H.R., Simeoni, Ilenia, Rivers, Elizabeth, Maimaris, Jesmeen, Penkett, Christopher J., Stephens, Jonathan, Deevi, Sri V.V., Sanchis-Juan, Alba, Gleadall, Nicholas S., Thomas, Moira J., Sargur, Ravishankar B., Gordins, Pavels, Baxendale, Helen E., Brown, Matthew, Tuijnenburg, Paul, Worth, Austen, Hanson, Steven, Linger, Rachel J., Buckland, Matthew S., Rayner-Matthews, Paula J., Gilmour, Kimberly C., Samarghitean, Crina, Seneviratne, Suranjith L., Sansom, David M., Lynch, Andy G., Megy, Karyn, Ellinghaus, Eva, Ellinghaus, David, Jorgensen, Silje F., Karlsen, Tom H., Stirrups, Kathleen E., Cutler, Antony J., Kumararatne, Dinakantha S., Chandra, Anita, Edgar, J. David M., Herwadkar, Archana, Cooper, Nichola, Grigoriadou, Sofia, Huissoon, Aarnoud P., Goddard, Sarah, Jolles, Stephen, Schuetz, Catharina, Boschann, Felix, Abbs, Stephen, Adhya, Zoe, Adlard, Julian, Afzal, Maryam, Ahmed, Irshad, Ahmed, Munaza, Ahmed, Saeed, Aitman, Timothy J., Alachkar, Hana, Alamelu, Jayanthi, Alikhan, Raza, Allen, Carl E., Allen, Louise, Allsup, David J., Alvi, Arif, Ambegaonkar, Gautam, Anantharachagan, Ariharan, Ancliff, Philip, Anderson, Julie, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Arumugakani, Gururaj, Arya, Rita, Ashford, Sofie, Astle, William J., Attwood, Anthony, Austin, Steve, Aydinok, Yesim, Ayub, Waqar, Babbs, Christian, Bacchelli, Chiara, Baglin, Trevor, Bakchoul, Tamam, Bariana, Tadbir K., Barratt, Jonathan, Barwell, Julian, Baski, John, Bates, Rachel W., Batista, Joana, Baynam, Gareth, Bennett, David L., Bethune, Claire, Bhatnagar, Neha, Bibi, Shahnaz, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria A.K., Bleda, Marta, Blesneac, Iulia, Boardman, Barbara, Boddana, Preetham, Bogaard, Harm J., Booth, Claire, Boyce, Sara, Bradley, John R., Brady, Angela, Breen, Gerome, Brennan, Paul, Brewer, Carole, Briley, Annette, Brown, Richard, Browning, Michael J., Brownlie, Mary, Bryson, Christine J., Buchan, Rachel J., Buck, Jackie, Bueser, Teofila, Diz, Carmen Bugarin, Burns, Siobhan O., Calleja, Paul, Carmichael, Jenny, Carr-White, Gerald, Carss, Keren J., Casey, Ruth, Chalmers, Elizabeth, Chambers, Jenny, Chambers, John, Chan, Melanie M.Y., Chan, Melissa V., Cheng, Floria, Chinn, Ivan K., Chinnery, Patrick F., Chitre, Manali, Chong, Sam, Christian, Martin T., Church, Colin, Clement, Emma M., Brod, Naomi Clements, Clifford, Hayley, Clowes, Virginia E., Coghlan, Gerry, Colby, Elizabeth, Cole, Trevor R.P., Collins, Janine H., Collins, Peter W., Condliffe, Robin, Cook, H. Terence, Cook, Stuart, Cookson, Victoria, Corris, Paul A., Creaser-Myers, Amanda, Crisp-Hihn, Abigail, Curry, Nicola S., Da Costa, Rosa, Danesino, Cesare, Daniels, Matthew J., Darby, Damaris, Daugherty, Louise C., Davies, E. G., Davies, Sophie, Davis, John, de Bree, Godelieve J., Deacock, Sarah, Deegan, Patrick B., Dempster, John, Dent, Timothy, Deshpande, Charu, Devlin, Lisa A., Dewhurst, Eleanor F., Dixit, Anand K., Dixon, Peter H., Doffinger, Rainer, Dolling, Helen, Dormand, Natalie, Downes, Kate, Drazyk, Anna M., Drewe, Elizabeth, Duarte, Daniel, Dutt, Tina, Edwards, Karen E., Egner, William, Ekani, Melanie N., El-Shanawany, Tariq, Elkhalifa, Shuayb, Elston, Tony, Emmerson, Ingrid, Erber, Wendy N., Erwood, Marie, Estiu, Maria C., Evans, Dafydd Gareth, Evans, Gillian, Everington, Tamara, Eyries, Mélanie, Favier, Remi, Firth, Helen V., Fitzpatrick, Maggie M., Fletcher, Debra, Flinter, Frances A., Fox, James C., Frary, Amy J., French, Courtney E., Freson, Kathleen, Frontini, Mattia, Furie, Bruce, Gale, Daniel P., Gall, Henning J., Gardham, Alice, Gaspar, H. Bobby, Gattens, Michael, Ghali, Neeti, Ghataorhe, Pavandeep K., Ghio, Stefano, Ghofrani, Hossein Ardeschir, Ghurye, Rohit, Gibbs, J. Simon R., Gilbert, Rodney D., Girerd, Barbara, Girling, Joanna C., Gissen, Paul, Gorman, Kathleen M., Gosal, David, Graf, Stefan, Grassi, Luigi, Greenhalgh, Alan J., Greenhalgh, Lynn, Greinacher, Andreas, Gresele, Paolo, Griffiths, Philip G., Griffiths, Sian, Grozeva, Detelina, Hackett, Scott J., Hadden, Robert D.M., Hadinnapola, Charaka, Hague, Rosie, Hague, William M., Haimel, Matthias, Hall, Matthew, Halmagyi, Csaba, Hammerton, Tracey, Hanson, Helen L., Harkness, Kirsty, Harper, Andrew R., Harper, Lorraine, Harris, Claire, Harrison, Claire, Hart, Daniel, Hassan, Ahamad, Hayman, Grant, Heemskerk, Johan W.M., Hegde, Shivaram, Henderson, Alex, Henderson, Robert H., Hensiek, Anke, Henskens, Yvonne M.C., Hodgson, Joshua, Hoffman, Jonathan, Holden, Simon, Holder, Muriel, Horvath, Rita, Houlden, Henry, Houweling, Arjan C., Howard, Luke S., Hu, Fengyuan, Hudson, Gavin, Hughes, Sean, Hughes, Stephen, Huis in ‘t Veld, Anna E., Humbert, Marc, Hurles, Matthew E., Hurst, Jane A., Irvine, Val, Izatt, Louise, James, Roger, Jeevaratnam, Praveen, Johnson, Mark, Johnson, Sally A., Jolley, Jennifer D., Jones, Bryony, Jones, Julie, Josifova, Dragana, Jurkute, Neringa, Karim, Yousuf M., Karoshi, Mahantesh A., Kasanicki, Mary A., Kazkaz, Hanadi, Kazmi, Rashid, Keeling, David, Kelleher, Peter, Kelly, Anne M., Kempster, Carly, Kennedy, Fiona, Kiani, Sorena, Kiely, David G., Kingston, Nathalie, Kinsey, Sally, Klein, Nigel, Klima, Robert, Knox, Ellen, Kostadima, Myrto A., Kovacs, Gabor, Koziell, Ania B., Kreuzhuber, Roman, Krishnakumar, Deepa, Kuijpers, Taco W., Kumar, Ajith, Kurian, Manju A., Laffan, James, Laffan, Michael A., Lalloo, Fiona, Lambert, Michele P., Lawman, Sarah H.A., Lawrie, Allan, Layton, D. 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Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

50. Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

Author

Leggett,Catherine, Lwin,Ei Mon Phyo, Ritchie,Usha, Song,Yunmei, Gerber,Jacobus P., Turner,Sean, Hague,William, Stark,Michael, Upton,Richard, and Garg,Sanjay

Subjects
Drug Design, Development and Therapy
Abstract

Catherine Leggett,1,* Ei Mon Phyo Lwin,2,* Usha Ritchie,1 Yunmei Song,2 Jacobus P Gerber,2 Sean Turner,1 William M Hague,3,4 Michael Stark,3,5 Richard Upton,2 Sanjay Garg2 1SA Pharmacy, Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia; 2School of Pharmacy and Medical Sciences, Reid Building, City East Campus, University of South Australia, Adelaide, SA 5000, Australia; 3Robinson Research Institute, University of Adelaide, North Adelaide, SA 5006, Australia; 4Obstetric Medicine, Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia; 5Neonatal Medicine, Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia*These authors contributed equally to this workCorrespondence: Sanjay GargCentre for Pharmaceutical Innovation and Development (CPID), School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, AustraliaTel +61 8 830 21575Fax +61 8 830 22389Email Sanjay.Garg@unisa.edu.auObjective: This study aimed to quantify the amount of perindopril and its active metabolite perindoprilat present in breast milk and corresponding maternal and infant plasma concentrations.Design: Prospective, longitudinal, observational.Setting: Tertiary specialist paediatric and obstetric hospital in Adelaide, South Australia.Population: Breastfeeding women actively treated with perindopril for hypertensive disorders postpartum.Methods: Eight breast milk samples and a single plasma sample were collected from each participant over a 24hrs period, and plasma samples were taken from eligible breastfed infants. Breast milk and plasma concentrations of perindopril and perindoprilat were analysed using a validated Liquid Chromatography tandem-Mass Spectrometry (LC-MS/MS) method.Main Outcome Measures: Mean breast milk concentrations of perindopril and perindoprilat, Relative Infant Dose (RID) < 10%, and Theoretical Infant Dose (TID).Results: Ten women and three infants participated in the study. The mean concentration of perindopril in breast milk for each participant ranged from 0.003 to 1.2 ng/mL and perindoprilat 0.2– 36 ng/mL. RID for perindopril was 0.0005– 0.2% and perindoprilat 0.03– 4.6%. TID for perindopril was 0.00045– 0.18 μg/kg/day and perindoprilat 0.032– 5.4 μg/kg/day. Infant plasma levels for perindopril ranged from 0.44 to 1.12 ng/mL and perindoprilat undetectable – 10.14 ng/mL. Maternal reports described normal infant growth and development.Conclusion: Infant exposure to perindopril and perindoprilat through breast milk is low. However, some infants were found to have plasma perindoprilat concentrations consistent with pharmacodynamic effects. Perindopril may be used in mothers of healthy term infants, provided the infant is carefully monitored.Keywords: perindopril, perindoprilat, LC-MS/MS, human plasma, human milk, clinical lactation, infant drug exposure

Published
2020

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