413 results on '"Hagiya, H."'
Search Results
2. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
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Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Good Health and Well Being ,Medical and Health Sciences ,Emergency & Critical Care Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
[This corrects the article DOI: 10.1186/s13054-016-1208-6.].
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- 2016
3. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
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Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, Tridente, A, and Nee, P
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Emergency & Critical Care Medicine ,Medical and Health Sciences - Published
- 2016
4. Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection
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Hagiya H, Tasaka K, Sendo T, and Otsuka F
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Infectious and parasitic diseases ,RC109-216 - Abstract
Hideharu Hagiya,1 Ken Tasaka,2 Toshiaki Sendo,2 Fumio Otsuka11Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2Department of Pharmacy, Okayama University Hospital, Okayama, JapanObjectives: Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxef (LMOX) for the treatment of S. maltophilia infection.Patients and methods: The observational study was retrospectively performed at Okayama University Hospital (Okayama, Japan) from January 2011 to December 2013. LMOX was administered to 12 patients with S. maltophilia infection, with eleven of those patients being admitted to the intensive care unit.Results: Underlying conditions of the patients included postoperation, hematological transplantation, hepatic transplantation, and burn. Major infectious foci were surgical site infection (six cases), respiratory infection (four cases), blood stream infection (three cases), and burn site infection (one case). The doses of LMOX administered ranged from 1 g/d to 3 g/d for ten adult patients and from 40 mg/kg/d to 80 mg/kg/d for two pediatric patients. Microbiologic failure was seen in five (41.7%) of 12 cases, and 30-day and hospital mortality rates were 25% and 50%, respectively. Minimum inhibitory concentrations of LMOX were higher in the deceased group (4–64 µg/mL) than in the surviving group (1–4 µg/mL).Conclusion: LMOX treatment is not recommended for the treatment of S. maltophilia infection. Further investigation would be needed before its clinical use.Keywords: latamoxef, Stenotrophomonas maltophilia, intensive care unit, revival
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- 2015
5. A Wolff–Parkinson–White syndrome revealed by the event of heat stroke
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Tanaka, S, primary, Hagiya, H, additional, and Otsuka, F, additional
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- 2022
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6. Postprandial reactive hypoglycemia detected with premature ventricular contraction
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Honda, H, primary, Tanaka, S, additional, Hagiya, H, additional, and Otsuka, F, additional
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- 2022
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7. Right-sided infective endocarditis with odontogenic infections
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Fukushima, S, primary, Fujita, K, additional, Hagiya, H, additional, and Otsuka, F, additional
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- 2022
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8. Splenomegaly in silent endocarditis
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Ishida, T, primary, Hagiya, H, additional, Yamamoto, Y, additional, Oguni, K, additional, and Otsuka, F, additional
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- 2022
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9. Tuberculous aortic aneurysm developed with miliary tuberculosis
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Tanaka, S, primary, Hagiya, H, additional, and Otsuka, F, additional
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- 2022
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10. Another factor with an adverse effect on hand hygiene compliance
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Hagiya, H., Fujita, Y., Kiguchi, T., and Higashionna, T.
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- 2024
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11. Mammalian Arachidonate 12-Lipoxygenases
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Yamamoto, S., Takahashi, Y., Hada, T., Hagiya, H., Suzuki, H., Reddy, G. R., Ueda, N., Arakawa, T., Nakamura, M., Matsuda, S., Taketani, Y., Yoshimoto, T., Azekawa, T., Morita, Y., Ishimura, K., Arase, S., Glasgow, W. C., Brash, A. R., Anton, M., Kühn, H., Honn, Kenneth V., editor, Nigam, Santosh, editor, and Marnett, Lawrence J., editor
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- 1997
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12. Helicobacter cinaedi-associated Carotid Arteritis
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Nakao, S., Hagiya, H., Kimura, K., Mitsui, T., Oyama, A., Hongyo, K., Takahashi, Y., Nakagami, F., Tomono, K., and Hiromi Rakugi
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Carotid Artery Diseases ,Male ,Arteritis ,Ceftriaxone ,Meropenem ,Anti-Bacterial Agents ,Helicobacter Infections ,Helicobacter ,Humans ,Thienamycins ,bacterial translocation ,atherosclerosis ,bacteremia ,Helicobacter cinaedi ,vascular infection ,Aged - Abstract
A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks. Although the relationship between H. cinaedi infection and atherosclerosis development remains unclear, the atherosclerotic changes in our patient's carotid artery might have been attributable to H. cinaedi infection.
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- 2018
13. Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis
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Komiya, T., Sato, K., Shioya, H., Inagaki, Y., Hagiya, H., Kozaki, R., Imai, M., Takada, Y., Maeda, T., Kurata, H., Kurono, M., Suzuki, R., Otsuki, K., Habashita, H., and Nakade, S.
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- 2013
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14. Endoscopic Manifestations and Clinical Characteristics of Cytomegalovirus Infection in the Upper Gastrointestinal Tract
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Iwamuro, M., Eisei Kondo, Tanaka, T., Hagiya, H., Kawano, S., Kawahara, Y., Otsuka, F., and Okada, H.
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Adult ,Male ,esophagus ,Hematopoietic Stem Cell Transplantation ,Stomach Diseases ,esophagogastroduodenoscopy ,Graft vs Host Disease ,duodenum ,Middle Aged ,Esophageal Diseases ,Sensitivity and Specificity ,Immunocompromised Host ,Upper Gastrointestinal Tract ,Cytomegalovirus Infections ,Humans ,Female ,Endoscopy, Digestive System ,Duodenal Diseases ,cytomegalovirus ,Immunosuppressive Agents ,stomach ,Aged ,Retrospective Studies - Abstract
We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). All 14 patients had been taking one or more immunosuppressive agents including cyclosporine (n=10), corticosteroids (n=9), mycophenolic acid (n=6), tacrolimus (n=3), and methotrexate (n=1). Tests for CMV antigenemia were positive in 11 patients (78.6%). EGD examinations revealed esophageal (n=3), gastric (n=9), and duodenal involvement (n=6). Macroscopically, esophageal lesions by CMV infection presented as redness (n=1), erosions (n=1), and ulcers (n=1). Gastric lesions manifested as redness (n=7), erosions (n=3), exfoliated mucosa (n=2), and verrucous erosions (n=1). Mucosal appearances in the duodenum varied: redness (n=2), ulcers (n=2), multiple erosions (n=2), single erosion (n=1), edema (n=1). CMV was detected even in the intact duodenal mucosa (n=1). In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients.
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- 2017
15. Broad-spectrum antibiotic prescriptions are discontinued unevenly throughout the week
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Kokado, R., primary, Hagiya, H., additional, Morii, D., additional, Okuno, H., additional, Yamamoto, N., additional, Hamaguchi, S., additional, Yoshida, H., additional, Miwa, Y., additional, and Tomono, K., additional
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- 2019
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16. Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997–2016
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Hagiya, H., primary, Koyama, T., additional, Zamami, Y., additional, Minato, Y., additional, Tatebe, Y., additional, Mikami, N., additional, Teratani, Y., additional, Ohshima, A., additional, Shinomiya, K., additional, Kitamura, Y., additional, Sendo, T., additional, Hinotsu, S., additional, Tomono, K., additional, and Kano, M. R., additional
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- 2018
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17. Trends in incidence and mortality of tuberculosis in Japan : a population-based study, 1997–2016
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Hagiya, H., Koyama, T., Zamami, Yoshito, Minato, Y., Tatebe, Y., Mikami, N., Teratani, Y., Ohshima, A., Shinomiya, K., Kitamura, Y., Sendo, T., Hinotsu, S., Tomono, K., Kano, M. R., Hagiya, H., Koyama, T., Zamami, Yoshito, Minato, Y., Tatebe, Y., Mikami, N., Teratani, Y., Ohshima, A., Shinomiya, K., Kitamura, Y., Sendo, T., Hinotsu, S., Tomono, K., and Kano, M. R.
- Abstract
Japan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes. Crude and age-adjusted incidence rates reduced from 33.9 to 13.9 and 37.3 to 11.3 per 100 000 population, respectively. Also, crude and age-adjusted mortality rates reduced from 2.2 to 1.5 and 2.8 to 1.0 per 100 000 population, respectively. Average APC in the incidence and mortality rates showed significant decline both in men (−6.2% and −5.4%, respectively) and women (−5.7% and −4.6%, respectively). Age-specific analysis demonstrated decreases in incidence and mortality rates for every age category, except for the incidence trend in the younger population. Although trends in active TB incidence and mortality rates in Japan have favourably decreased, the rate of decline is far from achieving TB elimination by 2035.
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- 2018
18. A nationwide survey of intravenous antimicrobial use in intensive care units in Japan
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Ohnuma, Tetsu, primary, Hayashi, Yoshiro, additional, Yamashita, Kazuto, additional, Marquess, John, additional, Lefor, Alan Kawarai, additional, Sanui, Masamitsu, additional, Andoh, K., additional, Egi, M., additional, Fujita, M., additional, Fujitani, S., additional, Gushima, Y., additional, Hagiya, K., additional, Hagiya, H., additional, Ide, T., additional, Iizuka, Y., additional, Ohnuma, T., additional, Itagaki, T., additional, Ito, T., additional, Ito, M., additional, Iwashita, Y., additional, Izawa, J., additional, Izuta, S., additional, Kabutan, K., additional, Kamochi, M., additional, Kashiura, M., additional, Matsuo, K., additional, Matsushima, H., additional, Miyazaki, D., additional, Miyazu, M., additional, Nagata, I., additional, Takei, T., additional, Nagatani, H., additional, Nakagawa, M., additional, Nakane, M., additional, Nishi, K., additional, Noguchi, M., additional, Nomura, T., additional, Nunomiya, S., additional, Obayashi, T., additional, Oda, T., additional, Oe, K., additional, Ota, K., additional, Saito, N., additional, Sako, S., additional, Sekino, M., additional, Seo, R., additional, Shiino, Y., additional, Shime, N., additional, Shimizu, K., additional, Takada, K., additional, Takimoto, K., additional, Taneda, M., additional, Uehara, K., additional, Unemoto, K., additional, Yamada, T., additional, and Yasuda, H., additional
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- 2018
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19. Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan
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Yamamoto, N., primary, Asada, R., additional, Kawahara, R., additional, Hagiya, H., additional, Akeda, Y., additional, Shanmugakani, R.K., additional, Yoshida, H., additional, Yukawa, S., additional, Yamamoto, K., additional, Takayama, Y., additional, Ohnishi, H., additional, Taniguchi, T., additional, Matsuoka, T., additional, Matsunami, K., additional, Nishi, I., additional, Kase, T., additional, Hamada, S., additional, and Tomono, K., additional
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- 2017
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20. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016
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Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A
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Good Health and Well Being ,Medical and Health Sciences ,Emergency & Critical Care Medicine - Abstract
[This corrects the article DOI: 10.1186/s13054-016-1208-6.].
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- 2016
21. Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997-2016.
- Author
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Hagiya, H., Koyama, T., Zamami, Y., Minato, Y., Tatebe, Y., Mikami, N., Teratani, Y., Ohshima, A., Shinomiya, K., Kitamura, Y., Sendo, T., Hinotsu, S., Tomono, K., and Kano, M. R.
- Abstract
Japan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes. Crude and age-adjusted incidence rates reduced from 33.9 to 13.9 and 37.3 to 11.3 per 100 000 population, respectively. Also, crude and age-adjusted mortality rates reduced from 2.2 to 1.5 and 2.8 to 1.0 per 100 000 population, respectively. Average APC in the incidence and mortality rates showed significant decline both in men (-6.2% and -5.4%, respectively) and women (-5.7% and -4.6%, respectively). Age-specific analysis demonstrated decreases in incidence and mortality rates for every age category, except for the incidence trend in the younger population. Although trends in active TB incidence and mortality rates in Japan have favourably decreased, the rate of decline is far from achieving TB elimination by 2035. [ABSTRACT FROM AUTHOR]
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- 2019
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- View/download PDF
22. Effects of antibiotics administration on the incidence of wound infection in percutaneous dilatational tracheostomy
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Hagiya, H., Naito, H., Hagioka, S., Shuji Okahara, Morimoto, N., Kusano, N., and Otsuka, F.
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Adult ,Aged, 80 and over ,Male ,airway management ,Critical Illness ,Incidence ,surgical site infection ,Antibiotic Prophylaxis ,Middle Aged ,Anti-Bacterial Agents ,Young Adult ,critically ill patient ,Tracheostomy ,percutaneous dilatational tracheostomy ,Japan ,Risk Factors ,Humans ,Surgical Wound Infection ,Female ,Aged ,Retrospective Studies - Abstract
The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups:those administered antibiotics perioperatively and those not administered antibiotics. Wound infections were noted in 7 cases (incidence rate, 2.36%) and no death was recorded. Of the 69 patients without antibiotics, 5 developed wound infections (incidence rate, 7.25%), while only 2 of the 228 patients with antibiotics developed wound infections (incidence rate, 0.88%) (p=0.002;risk ratio, 8.82;95% confidence interval, 1.67-46.6). Of the 7 cases of wound infection, 5 cases occurred during the early period after PDT (within 7 days). Collectively, the present results suggest that prophylactic administration of antibiotics may prevent the incidence of PDT-induced wound infection, especially in the early phase after the PDT procedures. The need for antibiotics in PDT should be reconsidered.
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- 2014
23. CT visualising infective vegetation
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Hagiya, H., primary, Hasegawa, K., additional, Asano, K., additional, and Otsuka, F., additional
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- 2014
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24. Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis
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Komiya, T, primary, Sato, K, additional, Shioya, H, additional, Inagaki, Y, additional, Hagiya, H, additional, Kozaki, R, additional, Imai, M, additional, Takada, Y, additional, Maeda, T, additional, Kurata, H, additional, Kurono, M, additional, Suzuki, R, additional, Otsuki, K, additional, Habashita, H, additional, and Nakade, S, additional
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- 2012
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25. Thermal fluctuations in perpendicular recording media: New methodology for estimation of activation moment
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Mamiya, H, primary, Hagiya, H, additional, Oba, Y, additional, Ohnuma, M, additional, Oku, T, additional, Suzuki, J, additional, Yokoyama, M, additional, Katayama, T, additional, Nishihara, Y, additional, Awano, H, additional, and Koda, T, additional
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- 2011
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26. Application of Laser Propulsion to Ground Launching System
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Uchida, S., primary, Yabe, T., additional, and Hagiya, H., additional
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- 2007
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27. Calcified spleen associated with Pneumocystis jirovecii infection.
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Yamamoto, K, Honda, H, Hagiya, H, and Otsuka, F
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PNEUMOCYSTIS pneumonia ,SPLEEN ,INFECTION ,MAGNETIC resonance imaging ,CHRONIC myeloid leukemia - Abstract
Graph: Figure 1. class="chapter-para">(A) Plain computed tomography showed a shrunken spleen with diffuse calcification. Abdominal plain computed tomography showed diffuse calcification in the shrunken spleen (Figure 1B). The patient had a past medical history of I Pneumocystis jirovecii i pneumonia secondary to CML treatment 27 years ago. [Extracted from the article]
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- 2021
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28. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
- Author
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Author et al, Bateman, R. M., Sharpe, M. D., Jagger, J. E., Ellis, C. G., Solé-Violán, J., López-Rodríguez, M., Herrera-Ramos, E., Ruíz-Hernández, J., Borderías, L., Horcajada, J., González-Quevedo, N., Rajas, O., Briones, M., Rodríguez de Castro, F., Rodríguez Gallego, C., Esen, F., Orhun, G., Ergin Ozcan, P., Senturk, E., Ugur Yilmaz, C., Orhan, N., Arican, N., Kaya, M., Kucukerden, M., Giris, M., Akcan, U., Bilgic Gazioglu, S., Tuzun, E., Riff, R., Naamani, O., Douvdevani, A., Takegawa, R., Yoshida, H., Hirose, T., Yamamoto, N., Hagiya, H., Ojima, M., Akeda, Y., Tasaki, O., Tomono, K., Shimazu, T., Ono, S., Kubo, T., Suda, S., Ueno, T., Ikeda, T., Ogura, H., Takahashi, H., Kang, J., Nakamura, Y., Kojima, T., Izutani, Y., Taniguchi, T., O, M., Dinter, C., Lotz, J., Eilers, B., Wissmann, C., Lott, R., Meili, M. M., Schuetz, P. S., Hawa, H., Sharshir, M., Aburageila, M., Salahuddin, N., Chantziara, V., Georgiou, S., Tsimogianni, A., Alexandropoulos, P., Vassi, A., Lagiou, F., Valta, M., Micha, G., Chinou, E., Michaloudis, G., Kodaira, A., Imaizumi, H., De la Torre-Prados, M. V., Garcia-De la Torre, A., Enguix-Armada, A., Puerto-Morlan, A., Perez-Valero, V., Garcia-Alcantara, A., Bolton, N., Dudziak, J., Bonney, S., Tridente, A., Nee, P., Nicolaes, G., Wiewel, M., Schultz, M., Wildhagen, K., Horn, J., Schrijver, R., Van der Poll, T., Reutelingsperger, C., Pillai, S., Davies, G., Mills, G., Aubrey, R., Morris, K., Williams, P., Evans, P., Gayat, E. G., Struck, J., Cariou, A., Deye, N., Guidet, B., Jabert, S., Launay, J., Legrand, M., Léone, M., Resche-Rigon, M., Vicaut, E., Vieillard-Baron, A., Mebazaa, A., Arnold, R., Capan, M., Linder, A., Akesson, P., Popescu, M., Tomescu, D., Sprung, C. L., Calderon Morales, R., Munteanu, G., Orenbuch-Harroch, E., Levin, P., Kasdan, H., Reiter, A., Volker, T., Himmel, Y., Cohen, Y., Meissonnier, J., Girard, L., Rebeaud, F., Herrmann, I., Delwarde, B., Peronnet, E., Cerrato, E., Venet, F., Lepape, A., Rimmelé, T., Monneret, G., Textoris, J., Beloborodova, N., Moroz, V., Osipov, A., Bedova, A., Sarshor, Y., Pautova, A., Sergeev, A., Chernevskaya, E., Odermatt, J., Bolliger, R., Hersberger, L., Ottiger, M., Christ-Crain, M., Mueller, B., Schuetz, P., Sharma, N. K., Tashima, A. K., Brunialti, M. K., Machado, F. R., Assuncao, M., Rigato, O., Salomao, R., Cajander, S. C., Rasmussen, G., Tina, E., Söderquist, B., Källman, J., Strålin, K., Lange, A. L., Sundén-Cullberg, J. S., Magnuson, A. M., Hultgren, O. H., Van der Geest, P., Mohseni, M., Linssen, J., De Jonge, R., Duran, S., Groeneveld, J., Miller, R., Lopansri, B. K., McHugh, L. C., Seldon, A., Burke, J. 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R., McCarron, E., Simants, S., Patanwala, I., Welters, I., Su, Y., Fernández Villanueva, J., Fernández Garda, R., López Lago, A., Rodríguez Ruíz, E., Hernández Vaquero, R., Tomé Martínez de Rituerto, S., Varo Pérez, E., Lefel, N., Schaap, F., Bergmans, D., Olde Damink, S., Van de Poll, M., Tizard, K., Lister, C., Poole, L., Ringaitiene, D., Gineityte, D., Vicka, V., Norkiene, I., Sipylaite, J., O’Loughlin, A., Maraj, V., Dowling, J., Velasco, M. B., Dalcomune, D. M., Dias, E. B., Fernandes, S. L., Oshima, T., Graf, S., Heidegger, C., Genton, L., Karsegard, V., Dupertuis, Y., Pichard, C., Friedli, N., Stanga, Z., Vandersteen, L., Stessel, B., Evers, S., Van Assche, A., Jamaer, L., Dubois, J., Castro, H., Valente, J., Martins, P., Casteloes, P., Magalhaes, C., Cabral, S., Santos, M., Oliveira, B., Salgueiro, A., Duarte, S., Castro, S., Melo, M., Gray, S., Maipang, K., Bhurayanontachai, R., Grädel, L. G., Schütz, P., Langlois, P., Manzanares, W., Lemieux, M., Elke, G., Bloos, F., Heyland, D., Aramendi, I., Babo, N., Hoshino, M., Haraguchi, Y., Kajiwara, S., Mitsuhashi, T., Tsubata, T., Aida, M., Rattanapraphat, T., Kongkamol, C., Xavier, B., Koutsogiannidis, C., Moschopoulou, M., Taskin, G., Çakir, M., Güler, AK, Taskin, A., Öcal, N., Özer, S., Yamanel, L., Wong, J. M., Fitton, C., Anwar, S., Stacey, S., Aggou, M., Fyntanidou, B., Patsatzakis, S., Oloktsidou, E., Lolakos, K., Papapostolou, E., Grosomanidis, V., Gaudry, S., Desailly, V., Pasquier, P., Brun, PB, Tesnieres, AT, Ricard, JD, Dreyfuss, D., Mignon, A., White, J. C, Stilwell, A., Friedlaender, G., Peters, M., Stipulante, S., Delfosse, A., Donneau, AF, Ghuysen, A., Feldmann, C., Freitag, D., Dersch, W., Irqsusi, M., Eschbach, D., Steinfeldt, T., Wulf, H., Wiesmann, T., Cholkraisuwat, J., Beitland, S., Nakstad, E., Stær-Jensen, H., Drægni, T., Andersen, G., Jacobsen, D., Brunborg, C., Waldum-Grevbo, B., Sunde, K., Hoyland, K., Pandit, D., Hayakawa, K., Kotzampassi, K., Loukipoudi, L., Doumaki, E., Admiraal, M. M., Van Assen, M., Van Putten, M. J., Tjepkema-Cloostermans, M., Van Rootselaar, A. F., Ragusa, F., Marudi, A., Baroni, S., Gaspari, A., Bertellini, E., Abdullah, T., Abdel Monem, S., Alcorn, S., McNeill, S., Russell, S., Eertmans, W., Genbrugge, C., Meex, I., Dens, J., Jans, F., De Deyne, C., Avard, B, Burns, R, Patarchi, A., Spina, T., Tanaka, H., Otani, N., Ode, S., Ishimatsu, S., Cho, J., Moon, J. B., Park, C. W., Ohk, T. G., Shin, M. C., Won, M. H., Dakova, S., Ramsheva, Z., Ramshev, K., Marudi, A, Baroni, S, Gaspari, A, Bertellini, E, Ozcan, P. E., Sencer, S., Ulusoy, C., Fallenius, M., Skrifvars, M. B., Reinikainen, M., Bendel, S., Raj, R., Abu-Habsa, M., Hymers, C., Borowska, A., Sivadhas, H., Sahiba, S., Perkins, S., Rubio, J., Rubio, J. A., Sierra, R., English, S., Chasse, M., Turgeon, A., Lauzier, F., Griesdale, D., Garland, A., Fergusson, D., Zarychanski, R., Tinmouth, A., Van Walraven, C., Montroy, K., Ziegler, J., Dupont Chouinard, R., Carignan, R., Dhaliwal, A., Lum, C., Sinclair, J., Pagliarello, G., McIntyre, L., Groza, T., Moreau, N., Castanares-Zapatero, D., Hantson, P., Carbonara, M., Ortolano, F., Zoerle, T., Magnoni, S., Pifferi, S., Conte, V., Stocchetti, N., Carteron, L., Suys, T., Patet, C., Quintard, H., Oddo, M., Spatenkova, V., Pokorna, E., Suchomel, P., Ebert, N., Bylinski, T., Hawthorne, C., Shaw, M., Piper, I., Kinsella, J., Kink, A. K., Rätsep, I. R., Boutin, A., Moore, L., Lacroix, J., Lessard-Bonaventure, P., Turgeon, A. F., Green, R., Erdogan, M., Butler, M., Desjardins, P., Fergusson, D. A., Goncalves, B., Vidal, B., Valdez, C., Rodrigues, A. C., Miguez, L., Moralez, G., Hong, T., Kutz, A., Hausfater, P., Amin, D., Struja, T., Haubitz, S., Huber, A., Brown, T., Collinson, J., Pritchett, C., Slade, T., Le Guen, M., Hellings, S., Ramsaran, R., Alsheikhly, A., Abe, T., Kanapeckaite, L., Bahl, R., Russell, M. Q., Real, K. J., Lyon, R. M., Oveland, N. P., Penketh, J., Mcdonald, M., Kelly, F., Alfafi, M., Almutairi, W., Alotaibi, B., Van den Berg, A. E, Schriel, Y., Dawson, L., Meynaar, I. A., Silva, D., Fernandes, S., Gouveia, J., Santos Silva, J., Foley, J., Kaskovagheorgescu, A., Evoy, D., Cronin, J., Ryan, J., Huck, M., Hoffmann, C., Renner, J., Laitselart, P., Donat, N., Cirodde, A., Schaal, J. V., Masson, Y., Nau, A., Howarth, O., Davenport, K., Jeanrenaud, P., Raftery, S., MacTavish, P., Devine, H., McPeake, J., Daniel, M., Quasim, T., Alrabiee, S., Alrashid, A., Gundogan, O., Bor, C., Akýn Korhan, E., Demirag, K., Uyar, M., Frame, F., Ashton, C., Bergstrom Niska, L., Dilokpattanamongkol, P., Suansanae, T., Suthisisang, C., Morakul, S., Karnjanarachata, C., Tangsujaritvijit, V., Mahmood, S., Al Thani, H., Almenyar, A., Morton, S. E., Chiew, Y. S., Pretty, C., Chase, J. G., Shaw, G. M., Kordis, P., Grover, V., Kuchyn, I., Bielka, K., Aidoni, Z., Stavrou, G., Skourtis, C., Lee, S. D., Williams, K., Weltes, I. D., Berhane, S., Arrowsmith, C., Peters, C., Robert, S., Panerai, R. B., Robinson, T. G., Borg-Seng-Shu, E., De Lima Oliveira, M., Mian, N. C., Nogueira, R., Zeferino, S. P., Jacobsen Teixeira, M., Killeen, P., McPhail, M., Bernal, W., Maggs, J., Wendon, J., Hughes, T., Taniguchi, L. U., Siqueira, E. M., Vieira Jr, J. M., Azevedo, L. C., Ahmad, A. N., Helme, E., Hadfield, S., Shak, J., Senver, C., Howard-Griffin, R., Wacharasint, P., Fuengfoo, P., Sukcharoen, N., Rangsin, R., Sbiti-Rohr, D., Na, H., Song, S., Lee, S., Jeong, E., Lee, K., Zoumpelouli, E., Volakli, E. A, Chrysohoidou, V., Charisopoulou, K., Kotzapanagiotou, E., Manavidou, K., Stathi, Z., AlGhamdi, B., Marashly, Q., Zaza, K., Khurshid, M., Ali, Z., Malgapo, M., Jamil, M., Shafquat, A., Shoukri, M., Hijazi, M., Rocha, F. A., Ebecken, K., Rabello, L. S., Lima, M. F., Hatum, R., De Marco, F. V., Alves, A., Pinto, J. E., Godoy, M., Brasil, P. E., Bozza, F. A., Salluh, J. I., Soares, M., Krinsley, J., Kang, G., Perry, J., Hines, H., Wilkinson, K. M., Tordoff, C., Sloan, B., Bellamy, M. C., Moreira, E., Verga, F., Barbato, M., Burghi, G., Soares, M, Silva, U. V., Torelly, A. P., Kahn, J. M., Angus, D. C., Knibel, M. F., Marshall, R., Gilpin, T., Mota, D., Loureiro, B., Dias, J., Afonso, O., Coelho, F., Martins, A., Faria, F., Al Orainni, H., AlEid, F., Tlaygeh, H., Itani, A., Hejazi, A., Messika, J., Ricard, J. D., Guillo, S., Pasquet, B., Dubief, E., Tubach, F., James, K., Temblett, P., Davies, L., Lynch, C., Pereira, S., Cavaco, S., Fernandes, J., Moreira, I., Almeida, E., Seabra Pereira, F., Malheiro, M., Cardoso, F., Aragão, I., Cardoso, T., Fister, M., Muraray Govind, P., Brahmananda Reddy, N., Pratheema, R., Arul, E. D., Devachandran, J., Chin-Yee, N., D’Egidio, G., Thavorn, K., Kyeremanteng, K., Murchison, A. G., Swalwell, K., Mandeville, J., Stott, D., Guerreiro, I., Goossens, C., Marques, M. B., Derde, S., Vander Perre, S., Dufour, T., Thiessen, S. E., Güiza, F., Janssens, T., Hermans, G., Vanhorebeek, I., De Bock, K., Van den Berghe, G., Langouche, L., Miles, B., Madden, S., Weiler, M., Marques, P., Rodrigues, C., Boeira, M., Brenner, K., Leães, C., Machado, A., Townsend, R., Andrade, J., Kishore, R., Fenlon, C., Fiks, T., Ruijter, A., Te Raa, M., Spronk, P., Docherty, P., Dickson, J., Moltchanova, E., Scarrot, C., Hall, T., Ngu, W. C., Jack, J. M., Pavli, A., Gee, X., Akin Korhan, E., Shirazy, M., Fayed, A., Gupta, S., Kaushal, A., Dewan, S., Varma, A., Ghosh, E., Yang, L., Eshelman, L., Lord, B., Carlson, E., Broderick, R., Ramos, J., Forte, D., Yang, F., Feeney, J., Wilkinson, K., Shuker, K., Faulds, M., Bryden, D., England, L., Shuker, K, Tridente, A, Faulds, M, Matheson, A, Gaynor, J., Bryden, D, ᅟ, S South Yorkshire Hospitals Research Collaboration, Peroni, B., Daglius-Dias, R., Miranda, L., Cohen, C., Carvalho, C., Velasco, I., Kelly, J. M., Neill, A., Rubenfeld, G., Masson, N., Min, A., Boezeman, E., Hofhuis, J., Hovingh, A., De Vries, R., Cabral-Campello, G., Van Mol, M., Nijkamp, M., Kompanje, E., Ostrowski, P., Kiss, K., Köves, B., Csernus, V., Molnár, Z., Hoydonckx, Y., Vanwing, S., Medo, V., Galvez, R., Miranda, J. P., Stone, C., Wigmore, T., Arunan, Y., Wheeler, A., Wong, Y., Poi, C., Gu, C., Molmy, P., Van Grunderbeeck, N., Nigeon, O., Lemyze, M., Thevenin, D., Mallat, J., Correa, M., Carvalho, R. T., Fernandez, A., McBride, C., Koonthalloor, E., Walsh, C., Webber, A., Ashe, M., Smith, K., Volakli, E. A., Dimitriadou, M., Mantzafleri, P., Vrani, O., Arbouti, A., Varsami, T., Bollen, J. A., Van Smaalen, T. C., De Jongh, W. C., Ten Hoopen, M. M., Ysebaert, D., Van Heurn, L. W., Van Mook, W. N., Roze des Ordons, A., Couillard, P., Doig, C., Van Keer, R. V., Deschepper, R. D., Francke, A. F., Huyghens, L. H., Bilsen, J. B., Nyamaizi, B., Dalrymple, C., Dobru, A., Marrinan, E., Ankuli, A., Struthers, R., Crawford, R., Mactavish, P., Morelli, P., Degiovanangelo, M., Lemos, F., MArtinez, V., Cabrera, J., Rutten, A., Van Ieperen, S., De Geer, S., Van Vugt, M., Der Kinderen, E., Giannini, A., Miccinesi, G, Marchesi, T, and Prandi, E
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health care facilities, manpower, and services ,education ,Erratum ,Critical Care and Intensive Care Medicine ,reproductive and urinary physiology ,humanities ,health care economics and organizations - Full Text
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29. Complication of chronic eosinophilic pneumonia in an elderly patient with Sjögren syndrome
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Waseda, K., Hagiya, H., Hanayama, Y., Terasaka, T., Kimura, K., Tsuzuki, T., Hasegawa, K., Nada, T., Nakamura, E., Murakami, K., Eisei Kondo, and Otsuka, F.
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Aged, 80 and over ,Male ,Prednisolone ,Administration, Oral ,respiratory system ,bronchial alveolar lavage ,Sjögren syndrome ,respiratory tract diseases ,stomatognathic diseases ,Sjogren's Syndrome ,Treatment Outcome ,eosinophilic pneumonia ,Adrenal Cortex Hormones ,Chronic Disease ,Humans ,interstitial lung diseases ,Pulmonary Eosinophilia ,eosinophilia - Abstract
An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patient's condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patient's clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients.
30. Examination of yield, bacteriolytic activity and cold storage of linker deletion mutants based on endolysin S6_ORF93 derived from Staphylococcus giant bacteriophage S6.
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Munetomo S, Uchiyama J, Takemura-Uchiyama I, Wanganuttara T, Yamamoto Y, Tsukui T, Hagiya H, Kanamaru S, Kanda H, and Matsushita O
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- Staphylococcus Phages genetics, Bacteriolysis, Escherichia coli genetics, Escherichia coli virology, Viral Proteins genetics, Viral Proteins metabolism, Viral Proteins chemistry, Cold Temperature, Endopeptidases genetics, Endopeptidases metabolism, Endopeptidases chemistry, Sequence Deletion
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Methicillin-resistant Staphylococcus spp. present challenges in clinical and veterinary settings because effective antimicrobial agents are limited. Phage-encoded peptidoglycan-degrading enzyme, endolysin, is expected to be a novel antimicrobial agent. The enzymatic activity has recently been shown to be influenced by the linker between functional domains in the enzyme. S6_ORF93 (ORF93) is one of the endolysins derived from previously isolated Staphylococcus giant phage S6. The ORF93 was speculated to have a catalytic and peptidoglycan-binding domain with a long linker. In this study, we examined the influence of linker shortening on the characteristics of ORF93. We produce wild-type ORF93 and the linker deletion mutants using an Escherichia coli expression system. These mutants were designated as ORF93-Δ05, ORF93-Δ10, ORF93-Δ15, and ORF93-Δ20, from which 5, 10, 15, and 20 amino acids were removed from the linker, respectively. Except for the ORF93-Δ20, ORF93 and its mutants were expressed as soluble proteins. Moreover, ORF93-Δ15 showed the highest yield and bacteriolytic activity, while the antimicrobial spectrum was homologous. The cold storage experiment showed a slight effect by the linker deletion. According to our results and other studies, linker investigations are crucial in endolysin development., Competing Interests: The authors declare that no competing interests exist., (Copyright: © 2024 Munetomo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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31. Zinc deficiency is a potential risk factor for COVID-19 progression to pneumonia requiring oxygen therapy.
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Fujita K, Ocho K, Kadowaki T, Yorifuji T, Hagiya H, and Otsuka F
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- Humans, Male, Female, Risk Factors, Aged, Middle Aged, Severity of Illness Index, Disease Progression, Nutritional Status, Aged, 80 and over, Retrospective Studies, Comorbidity, COVID-19 complications, COVID-19 therapy, COVID-19 blood, Zinc deficiency, Zinc blood, Oxygen Inhalation Therapy, SARS-CoV-2
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Introduction: Various risk factors for developing severe coronavirus disease 2019 (COVID-19) have been reported. However, studies on the nutritional-related risk factors are limited. In this study, we investigated the effects of serum zinc deficiency on the severity of COVID-19., Methods: The study included a total of 60 COVID-19 patients who were admitted to Tsuyama Chuo Hospital between March 2020 and April 2021. We divided the patients into two categories based on serum levels of zinc (normal and latent zinc deficiency vs. zinc deficiency [<60 μg/dL]) at the time of diagnosis. Severity of COVID-19 was defined as the most exaggerated disease status during admission. The associations between serum zinc deficiency and the severity of COVID-19 were examined using a logistic regression model adjusted for potential confounders., Results: Patients who required oxygen therapy had a higher prevalence of comorbidities and poorer nutritional status, including zinc deficiency, than those who did not require oxygen therapy. Zinc deficiency was associated with an increased risk of COVID-19 severity, with an adjusted odds ratio of 7.29 (95% confidence interval: 1.70-31.18). This result remained significant in the sensitivity analyses conducted after adjusting for patient background factors., Conclusions: Zinc deficiency at the time of COVID-19 diagnosis is an independent risk factor for severe disease. Our findings need to be validated in external studies., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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32. Antibody Titers and the Risk of Infection During the SARS-CoV-2 Omicron Phase in Bizen City, Japan.
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Kadowaki T, Sasaki A, Matsumoto N, Mitsuhashi T, Hagiya H, Takao S, and Yorifuji T
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- Humans, Japan epidemiology, Female, Male, Prospective Studies, Middle Aged, Adult, Aged, Risk Factors, COVID-19 immunology, COVID-19 epidemiology, Antibodies, Viral blood, SARS-CoV-2 immunology
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Background: Understanding the association between the immune response and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has implications for forthcoming prevention strategies. We evaluated the association between antibody titers and the risk of infection for the general population during the Omicron-dominant phase., Methods: This was a prospective cohort study of residents or people affiliated with institutions in Bizen City, which included 1899 participants. We measured the titers of antibodies against SARS-CoV-2 repeatedly every 2 months from June 2022 to March 2023. Infection status was obtained from self-reported questionnaires and the official registry. We estimated risk ratios (RRs) for infection within 2 months of the date of each antibody measurement with 95% confidence intervals (CIs) based on antibody titer categories and spline functions., Results: Compared with the <2500 arbitrary unit (AU)/mL category, the 2500-5000, 5000-10 000, and ≥10 000 AU/mL categories had adjusted RRs of 0.81 (95% CI, .61-1.08), 0.51 (95% CI, .36-.72), and 0.41 (95% CI, .31-.54), respectively. The spline function showed a nonlinear relationship between antibody titer and risk., Conclusions: Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future prevention strategies., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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33. Threat of MRSA bacteremia still matters: a propensity score matching analysis.
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Fukushima S, Hagiya H, Kuninaga N, Haruki Y, Yamada H, Iwamoto Y, Yoshida M, Sato K, Hanayama Y, Tanaka S, Miyoshi T, Otsuka Y, Ueda K, and Otsuka F
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- 2024
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34. Cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus clinical isolates.
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Tsuji S, Gotoh K, Manabe T, Iio K, Fukushima S, Matsushita O, and Hagiya H
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- Humans, Japan, Methicillin pharmacology, beta-Lactamases genetics, Cefazolin pharmacology, Anti-Bacterial Agents pharmacology, Staphylococcal Infections microbiology, Staphylococcus aureus drug effects, Staphylococcus aureus genetics, Staphylococcus aureus isolation & purification, Microbial Sensitivity Tests
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We investigated the prevalence and characteristics of Cefazolin inoculum effect (CInE) among clinical MSSA isolates in Japan. Although 35.5 % (39 isolates) were positive for the blaZ gene, none met the phenotypic criteria for CInE. Our findings suggested a very low prevalence of CInE among MSSA isolates in our clinical setting., Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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35. Rapid diagnostic testing for GAS necrotizing fasciitis.
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Fukushima S, Hagiya H, Okura M, and Iio K
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- Humans, Male, Gas Gangrene diagnosis, Female, Fasciitis, Necrotizing diagnosis
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- 2024
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36. Mimicker of Gram-positive Staphylococci.
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Fukushima S, Fujimori T, and Hagiya H
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- Humans, Staphylococcus isolation & purification, Staphylococcus drug effects, Male, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Staphylococcal Infections diagnosis, Staphylococcal Infections microbiology
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- 2024
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37. Cryptococcal prostatitis in an immunocompromised patient with tocilizumab and glucocorticoid therapy: A case report.
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Oguni K, Fukushima S, Hagiya H, Kato A, Suyama A, Iwata T, Miyawaki Y, Ono S, Iio K, and Otsuka F
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Cryptococcus prostatitis is an uncommon manifestation of cryptococcal infection that occurs mostly in immunocompromised patients. Tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, has been associated with an increased risk of cryptococcal infections. However, there have been no documented cases of cryptococcal prostatitis in patients receiving tocilizumab therapy. We report a case of cryptococcal prostatitis in a 72-year-old man treated with glucocorticoids and tocilizumab for giant cell arteritis and granulomatosis with polyangiitis. The patient presented dysuria and his serum level of prostate-specific antigen was elevated. Magnetic resonance imaging revealed a prostate mass, and a prostate biopsy was performed, leading to a pathologic diagnosis of cryptococcal prostatitis. Fungal cultures for blood and urine were negative, while the cryptococcal antigen for both serum and urine showed positive results. There were no particular findings in the pulmonary and central nervous systems. The patient was successfully treated with oral fluconazole (400 mg/day) and was discharged. Although cryptococcal prostatitis is a rare entity, clinicians should note that an immunosuppressed patient may develop such a difficult-to-diagnose disease., Competing Interests: Declaration of competing interest The authors have no conflicts of interest., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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38. Ghost in blood culture.
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Fukushima S, Hagiya H, Okura M, and Iio K
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- 2024
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39. Effectiveness of sensing gloves-applied virtual reality education system on hand hygiene practice: A randomized controlled trial.
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Izumi M, Hagiya H, Otsuka Y, Soejima Y, Fukushima S, Shibata M, Hirota S, Koyama T, Otsuka F, and Gofuku A
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Background: We developed a virtual reality (VR) education system and evaluated its clinical utility for promoting hand hygiene practices., Methods: This prospective, 2-week, randomized controlled study conducted at Okayama University Hospital, Japan, from November 2023 to January 2024, involved 22 participants (18 medical students and 4 residents). A fully immersive 360° VR system (VIVE Pro Eye) using a head-mounted display and sensing gloves was used to develop 3 health care tasks in a virtual patient room-Environmental Cleaning, Gauze Exchange, and Urine Collection. After monitoring all participants' baseline usage data of portable hand-rubbing alcohol in the first week, we randomly assigned them into 1:1 groups (VR training and video lecture groups). The primary outcome was differences in hand-rubbed alcohol use before and after intervention., Results: Before the intervention, alcohol use did not significantly differ between both groups. After the intervention, a significant increase in alcohol use was observed in the VR training group (median: 8.2 g vs 16.2 g; P = .019) but not in the video lecture group., Conclusions: Our immersive 360° VR education system enhanced hand hygiene practices. Infection prevention and control practitioners and digital technology experts must collaborate to advance the development of superior educational devices and content., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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40. Detection of imported clinical strain of blaNDM-1-harbouring ST147 Klebsiella pneumoniae from a Ukrainian immigrant.
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Fukushima S, Hagiya H, Gotoh K, Tsuji S, Iio K, and Matsushita O
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- Humans, Anti-Bacterial Agents therapeutic use, Microbial Sensitivity Tests, Ukraine, Female, Aged, Refugees, beta-Lactamases genetics, Emigrants and Immigrants, Klebsiella Infections diagnosis, Klebsiella Infections microbiology, Klebsiella Infections drug therapy, Klebsiella pneumoniae isolation & purification, Klebsiella pneumoniae genetics
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- 2024
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41. Adherence to and clinical utility of "quality indicators" for Staphylococcus aureus bacteremia: a retrospective, multicenter study.
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Fukushima S, Hagiya H, Kuninaga N, Haruki Y, Yamada H, Iwamoto Y, Yoshida M, Sato K, Hanayama Y, Tanaka S, Miyoshi T, Otsuka Y, Ueda K, and Otsuka F
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- Humans, Retrospective Studies, Male, Female, Aged, Middle Aged, Japan, Anti-Bacterial Agents therapeutic use, Aged, 80 and over, Guideline Adherence statistics & numerical data, Adult, Bacteremia drug therapy, Bacteremia diagnosis, Bacteremia microbiology, Staphylococcal Infections drug therapy, Staphylococcal Infections diagnosis, Staphylococcal Infections microbiology, Staphylococcus aureus drug effects, Staphylococcus aureus isolation & purification, Quality Indicators, Health Care statistics & numerical data
- Abstract
Background: We aimed to improve the prognosis, treatment, and management of Staphylococcus aureus bacteremia (SAB) by evaluating the association between adherence to quality indicators (QIs) and clinical outcomes in patients with their clinical outcomes., Methods: We retrospectively collected clinical and microbiological data on hospitalized patients with SAB from 14 hospitals (three with > 600, two with 401-600, five with 201-400, and four with ≤ 200 beds) in Japan from January to December 2022. The SAB management quality was evaluated using the SAB-QI score (ranging from 0 to 13 points), which consists of 13 QIs (grouped into five categories) based on previous literature., Results: Of the 4,448 positive blood culture episodes, 289 patients with SAB (6.5%) were enrolled. The SAB-QI scores ranged from 3 to 13, with a median score of 9 points. The SAB-QI score was highest in middle-sized hospitals with 401-600 beds. Adherence to each of the four QI categories (blood culture, echocardiography, source control, and antibiotic treatment) was significantly higher in survived cases than in fatal cases. Kaplan-Meier curves with log-rank tests demonstrated that higher adherence to SAB-QIs indicated a better prognosis. Logistic regression analysis revealed that age, methicillin resistance, multiple comorbidities (≥ 2), and low SAB-QI score were significantly associated with 30-day mortality in patients with SAB., Conclusions: Our study highlights that greater adherence to the SAB-QIs correlates with improved patient outcomes. Management of patients with SAB should follow these recommended indicators to maintain the quality of care, especially for patients with poor prognosticators., (© 2024. The Author(s).)
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- 2024
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42. Narrower-Spectrum Therapeutic Approaches Are Warranted for Aspiration Pneumonia.
- Author
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Hagiya H and Fukushima S
- Subjects
- Humans, Anti-Bacterial Agents therapeutic use, Pneumonia, Aspiration etiology
- Abstract
Competing Interests: Financial/Nonfinancial Disclosures None declared.
- Published
- 2024
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43. Clinical characteristics of female long COVID patients with menstrual symptoms: a retrospective study from a Japanese outpatient clinic.
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Sakurada Y, Matsuda Y, Motohashi K, Hasegawa T, Otsuka Y, Nakano Y, Tokumasu K, Yamamoto K, Sunada N, Honda H, Hagiya H, Ueda K, and Otsuka F
- Subjects
- Humans, Female, Retrospective Studies, Japan epidemiology, Post-Acute COVID-19 Syndrome, Quality of Life, Ambulatory Care Facilities, Fatigue, Menstruation Disturbances epidemiology, COVID-19
- Abstract
Purpose: To elucidate the impact of long COVID on menstruation and mental health, medical records of patients with long COVID were evaluated., Methods: Symptoms of long COVID, QOL, mental health, and related endocrine data were compared between two groups with and without menstrual disturbances., Results: Of 349 female patients who visited our clinic between February 2021 and March 2023, 223 patients with long COVID (aged 18-50 years) were included. Forty-four (19.7%) of the patients had menstrual symptoms associated with long COVID. The patients with menstrual symptoms were older than those without menstrual symptoms (42.5 vs. 38 years). The percentage of patients with menstrual symptoms was higher during the Omicron phase (24%) than during the Preceding (13%) and Delta (12%) phases. Cycle irregularity was the most frequent (in 63.6% of the patients), followed by severe pain (25%), heavy bleeding (20.5%), perimenopausal symptoms (18.2%), and premenstrual syndrome (15.9%). Fatigue and depression were the most frequent complications. Scores for fatigue and for QOL were significantly worse in long COVID patients with menstrual symptoms. Results of endocrine examinations showed significantly increased cortisol levels in patients with menstrual complaints., Conclusion: Long COVID has an impact on menstrual conditions and on QOL related to menstrual conditions.
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- 2024
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44. Detailed regimens for the prolonged β-lactam infusion therapy.
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Hagiya H
- Subjects
- Humans, Infusions, Intravenous, Randomized Controlled Trials as Topic, Shock, Septic drug therapy, Shock, Septic mortality, Treatment Outcome, Drug Administration Schedule, beta-Lactams administration & dosage, beta-Lactams therapeutic use, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Sepsis drug therapy, Sepsis mortality
- Abstract
A recent systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of prolonged versus intermittent β-lactam infusion in adult sepsis patients. The findings revealed a significant decrease in all-cause mortality and marked clinical success in the prolonged infusion group. Unfortunately, however, the manuscript lacked data and discussion for the specific regimens of prolonged β-lactam infusion defined in the included 15 RCT studies, which are herein additionally provided. Excluding one RCT, all protocols adopted a continuous infusion for the prolonged treatment. Except for three RCTs, dosages and timings of bolus injection were clearly defined. The total daily antibiotic dose for the continuous therapy was equivalent to those recommended for intermittent therapy. We believe this supplementary data aids clinicians in providing prolonged β-lactam infusions, contributing to enhanced treatment outcomes for patients suffering from severe sepsis or septic shock., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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45. Letter to the Editor: "Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19".
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Hagiya H
- Published
- 2024
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46. Ethical consumption of antimicrobial agents: A proposal for a new concept in promoting antimicrobial stewardship.
- Author
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Hagiya H
- Abstract
Competing Interests: Declaration of competing interest The author has no financial or other conflicts of interest to disclose.
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- 2024
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47. Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients.
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Tsuge M, Ichihara E, Hasegawa K, Kudo K, Tanimoto Y, Nouso K, Oda N, Mitsumune S, Kimura G, Yamada H, Takata I, Mitsuhashi T, Taniguchi A, Tsukahara K, Aokage T, Hagiya H, Toyooka S, Tsukahara H, and Maeda Y
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Adult, SARS-CoV-2, Nitric Oxide blood, Nitric Oxide metabolism, Prospective Studies, Citrulline blood, COVID-19 blood, COVID-19 virology, Oxidative Stress, Biomarkers blood
- Abstract
This study investigated the correlation between oxidative stress and blood amino acids associated with nitric oxide metabolism in adult patients with coronavirus disease (COVID-19) pneumonia. Clinical data and serum samples were prospectively collected from 100 adult patients hospitalized for COVID-19 between July 2020 and August 2021. Patients with COVID-19 were categorized into three groups for analysis based on lung infiltrates, oxygen inhalation upon admission, and the initiation of oxygen therapy after admission. Blood data, oxidative stress-related biomarkers, and serum amino acid levels upon admission were compared in these groups. Patients with lung infiltrations requiring oxygen therapy upon admission or starting oxygen post-admission exhibited higher serum levels of hydroperoxides and lower levels of citrulline compared to the control group. No remarkable differences were observed in nitrite/nitrate, asymmetric dimethylarginine, and arginine levels. Serum citrulline levels correlated significantly with serum lactate dehydrogenase and C-reactive protein levels. A significant negative correlation was found between serum levels of citrulline and hydroperoxides. Levels of hydroperoxides decreased, and citrulline levels increased during the recovery period compared to admission. Patients with COVID-19 with extensive pneumonia or poor oxygenation showed increased oxidative stress and reduced citrulline levels in the blood compared to those with fewer pulmonary complications. These findings suggest that combined oxidative stress and abnormal citrulline metabolism may play a role in the pathogenesis of COVID-19 pneumonia.
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- 2024
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48. New Delhi Metallo-Beta-Lactamase Inhibitors: A Systematic Scoping Review.
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Nahar L, Hagiya H, Gotoh K, Asaduzzaman M, and Otsuka F
- Abstract
Background/Objectives : Among various carbapenemases, New Delhi metallo-beta-lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all beta-lactam antibiotics, often conferring multi-drug resistance to the microorganism. The objective of this review is to synthesize current scientific data on NDM inhibitors to facilitate the development of future therapeutics for challenging-to-treat pathogens. Methods : Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews, we conducted a MEDLINE search for articles with relevant keywords from the beginning of 2009 to December 2022. We employed various generic terms to encompass all the literature ever published on potential NDM inhibitors. Results : Out of the 1760 articles identified through the database search, 91 met the eligibility criteria and were included in our analysis. The fractional inhibitory concentration index was assessed using the checkerboard assay for 47 compounds in 37 articles, which included 8 compounds already approved by the Food and Drug Administration (FDA) of the United States. Time-killing curve assays (14 studies, 25%), kinetic assays (15 studies, 40.5%), molecular investigations (25 studies, 67.6%), in vivo studies (14 studies, 37.8%), and toxicity assays (13 studies, 35.1%) were also conducted to strengthen the laboratory-level evidence of the potential inhibitors. None of them appeared to have been applied to human infections. Conclusions : Ongoing research efforts have identified several potential NDM inhibitors; however, there are currently no clinically applicable drugs. To address this, we must foster interdisciplinary and multifaceted collaborations by broadening our own horizons.
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- 2024
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49. Evidence Still Pending: Post-exposure Prophylactic Measures Against Varicella-Zoster Virus.
- Author
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Hagiya H and Fukushima S
- Subjects
- Humans, Chickenpox prevention & control, Antiviral Agents therapeutic use, Antiviral Agents administration & dosage, Varicella Zoster Virus Infection prevention & control, Herpesvirus 3, Human immunology, Post-Exposure Prophylaxis
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- 2024
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50. Disseminated septic arthritis caused by Ureaplasma urealyticum in an immunocompromised patient with hypogammaglobulinemia after rituximab therapy.
- Author
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Oguni K, Fukushima S, Otsuka Y, Soejima Y, Kawaguchi M, Sazumi Y, Fujimori T, Iio K, Umakoshi N, Yamada K, Hagiya H, and Otsuka F
- Abstract
Purpose: Ureaplasma urealyticum is a rare pathogen associated with septic arthritis that predominantly affects patients with hypogammaglobulinemia. Bacterial identification of fastidious organisms is challenging because they are undetectable by routine culture testing. To the best of our knowledge, this is the first report of septic arthritis induced by U. urealyticum infection in Japan., Case Description: We describe the case of a 23-year-old Japanese female with secondary hypogammaglobulinemia (serum immunoglobulin level < 500 mg/dL), identified 8 years after treatment with rituximab. The patient presented with persistent fever and polyarthritis that were unresponsive to ceftriaxone and prednisolone. Contrast-enhanced computed tomography and gallium-67 scintigraphy revealed effusion and inflammation in the left sternoclavicular, hip, wrist, knee, and ankle joints. Although Gram staining and bacterial culture of the drainage fluid from the left hip joint were negative, the condition exhibited characteristics of purulent bacterial infection. The patient underwent empirical treatment with doxycycline, and her symptoms promptly resolved. Subsequent 16S ribosomal RNA (rRNA) gene sequencing of the joint fluid confirmed the presence of U. urealyticum, leading to the diagnosis of septic arthritis. Combination therapy with doxycycline and azithromycin yielded a favorable recovery from the inflammatory status and severe arthritic pain., Conclusion: This case highlights U. urealyticum as a potential causative agent of disseminated septic arthritis, particularly in patients with hypogammaglobulinaemia. The 16S rRNA gene analysis proved beneficial for identifying pathogens in culture-negative specimens, such as synovial fluid, in suspected bacterial infections., (© 2024. The Author(s).)
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- 2024
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