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Lung Adenocarcinoma is one of the most leading causes of death worldwide. Early detection of this cancer could enhance the survival chance of patients and even lead to better and more effective treatment. One of the approaches to find out more about biological malfunctions is using "omics" data. Among diverse computational procedures, data integration is becoming a striking tool to deal with complicated diseases such as cancer, considering the defective and informative nature of each kind of "omics" data. Data integration as relates to lung adenocarcinoma can lead to finding molecular biomarkers that could solve early-stage detection and progression prediction alongside other screening technologies like low-dose spiral computed tomography. In the present study, we hypothesized that genes with multiple variations are essential to provoke lung adenocarcinoma and one may use them to predict tumor formation or even cancer development. We integrated the genomic, epigenomic, transcriptomic and proteomic data. Consequently, five genes were introduced and validated by different analyses including classification of patients and survival analysis. Furthermore, we constructed a bipartite mRNA-miRNA network to identify a set of miRNAs for further experimental analyses. Finally, a sensitive and specific diagnostic panel comprising CDKN2A, CX3CR1, COX4I2, SLC15A2 and TFRC genes were identified for early detection of Lung Adenocarcinoma., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Cellular uptake of nanoparticles (NPs) depends on the nature of the nanobio system including the solid nanocomponents ( e. g., physicochemical properties of NPs), nanobio interfaces ( e. g., protein corona composition), and the cellular characteristics ( e. g., cell type). In this study, we document the role of sex in cellular uptake of NPs as an "overlooked" factor in nanobio interface investigations. We demonstrate that cell sex leads to differences in NP uptake between male and female human amniotic stem cells (hAMSCs), with greater uptake by female cells. hAMSCs are one of the earliest sources of somatic stem cells. The experiments were replicated with primary fibroblasts isolated from the salivary gland of adult male and female donors of similar ages, and again the extent of NP uptake was altered by cell sex. However, in contrast to hAMSCs, uptake was greater in male cells. We also found out that female versus male amniotic stem cells exhibited different responses to reprogramming into induced pluripotent stem cells (iPSCs) by the Yamanaka factors. Thus, future studies should consider the effect of sex on the nanobio interactions to optimize clinical translation of NPs and iPSC biology and to help researchers to better design and produce safe and efficient therapeutic sex-specific NPs.