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19 results on '"Haggerty, Thomas D."'

1. Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination

Author

Tan, Susanna K, Granados, Andrea C, Bouquet, Jerome, Hoy-Schulz, Yana Emmy, Green, Lauri, Federman, Scot, Stryke, Doug, Haggerty, Thomas D, Ley, Catherine, Yeh, Ming-Te, Jannat, Kaniz, Maldonado, Yvonne A, Andino, Raul, Parsonnet, Julie, and Chiu, Charles Y

Subjects
Immunization, Prevention, Pediatric, Vaccine Related, Digestive Diseases, Clinical Research, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Antibodies, Neutralizing, Antibodies, Viral, Bangladesh, Feces, Female, Humans, Immunization Schedule, Infant, Male, Metagenome, Metagenomics, Poliomyelitis, Poliovirus, Poliovirus Vaccine, Inactivated, Poliovirus Vaccine, Oral, Vaccination, Virome, Virus Shedding
Abstract

The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antibodies. The abundance (p = 0.006) and richness (p = 0.013) of the eukaryotic virome increased with age and were higher than seen in age-matched US infants (p

Published
2020

3. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

Author

Zhang, Jianan, Walker, Morgan E., Sanidad, Katherine Z., Zhang, Hongna, Liang, Yanshan, Zhao, Ermin, Chacon-Vargas, Katherine, Yeliseyev, Vladimir, Parsonnet, Julie, Haggerty, Thomas D., Wang, Guangqiang, Simpson, Joshua B., Jariwala, Parth B., Beaty, Violet V., Yang, Jun, Yang, Haixia, Panigrahy, Anand, Minter, Lisa M., Kim, Daeyoung, Gibbons, John G., Liu, LinShu, Li, Zhengze, Xiao, Hang, Borlandelli, Valentina, Overkleeft, Hermen S., Cloer, Erica W., Major, Michael B., Goldfarb, Dennis, Cai, Zongwei, Redinbo, Matthew R., and Zhang, Guodong

Published
2022
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9. Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved

Author

Wang, Guangqiang, primary, Zhang, Hongna, additional, Zhang, Jianan, additional, Sanidad, Katherine Z., additional, Yeliseyev, Vladimir, additional, Parsonnet, Julie, additional, Haggerty, Thomas D., additional, Yang, Haixia, additional, Ai, Lianzhong, additional, Xie, Minhao, additional, Cai, Zongwei, additional, and Zhang, Guodong, additional

Published
2021
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10. Gastroenteritis and transmission of Helicobacter pylori infection in households (1)

Author

Perry, Sharon, de la Luz Sanchez, Maria, Yang, Shufang, Haggerty, Thomas D., Hurst, Philip, Perez-Perez, Guillermo, and Parsonnet, Julie

Subjects
Helicobacter infections -- Research, Helicobacter infections -- Development and progression, Helicobacter infections -- Prevention, Gastroenteritis -- Development and progression, Gastroenteritis -- Prevention, Gastroenteritis -- Research, Health surveys
Abstract

The mode of transmission of Helicobacter pylori infection is poorly characterized. In northern California, 2,752 household members were tested for H. pylori infection in serum or stool at a baseline [...]

Published
2006

19. Significance of Transiently Positive Enzyme-Linked Immunosorbent Assay Results in Detection of Helicobacter pyloriin Stool Samples from Children

Author

Haggerty, Thomas D., Perry, Sharon, Sanchez, Luz, Perez-Perez, Guillermo, and Parsonnet, Julie

Abstract

ABSTRACTIn young children, the significance of stool samples transiently positive for Helicobacter pyloriantigen is unknown. As part of a larger prospective study on enteric infections, stool samples were obtained from 323 children at two time points 3 months apart and tested for H. pyloriantigen using a commercially available enzyme-linked immunosorbent assay (ELISA) test. Seminested PCR for a Helicobacter-specific 16S rRNA gene was performed on all 26 pairs reverting from positive to negative (transient positives), all 4 persistent antigen-positive pairs, and 10 randomly selected persistent antigen-negative pairs. Helicobacterspecies were amplified from the first stool samples of 15/26 (58%) of the transient positives and 1 (25%) of 4 persistent positives. No Helicobacterspecies were amplified from the 10 persistent negatives. Among the 15 amplicons from transient-positive stool, H. pyloriwas sequenced and identified from 12 (80%; 95% confidence interval, 52% to 96%) and other Helicobacterspp. were identified from three (Helicobacter canis, Helicobacter winghamensis, and MIT 99-5504). Four of the 15 remained positive by PCR for the second (antigen-negative) stool sample, including all 3 initially identified as non-H. pylori. Helicobacter biliswas amplified from the second sample of a persistent positive. Two of eight transient positives from whom serum was available had accompanying transient elevations in anti-H. pyloriantibodies. Transiently positive stool ELISAs for H. pyloriare common and represent H. pyloriin the majority of cases where sequences can be obtained. A not-insignificant percentage of antigen-positive stools, however, may represent other Helicobacterspecies.

Published
2005
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