135,372 results on '"Hagen A"'
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2. Author Correction: Adherence to the transfer recommendations of the German Trauma Society in severely injured children: a retrospective study from the TraumaRegister DGU
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Felix Marius Bläsius, Markus Laubach, Rolf Lefering, Frank Hildebrand, and Hagen Andruszkow
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Medicine ,Science - Published
- 2024
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3. Predicting tracheostomy in multiple injured patients with severe thoracic injury (AIS ≥ 3) with the new T3P-Score: a multivariable regression prediction analysis
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Felix M. Bläsius, Sebastian Wutzler, Philipp Störmann, Thomas Lustenberger, Michael Frink, Marc Maegele, Matthias Weuster, Jörg Bayer, Klemens Horst, Michael Caspers, Andreas Seekamp, Ingo Marzi, Frank Hildebrand, and Hagen Andruszkow
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Medicine ,Science - Abstract
Abstract Multiple trauma patients with severe chest trauma are at increased risk for tracheostomy. While the risk factors associated with the need for tracheostomy are well established in the general critical care population, they have not yet been validated in a cohort of patients suffering severe thoracic trauma. This retrospective cohort study analysed data on patients aged 18 years or older who were admitted to one of the six participating academic level I trauma centres with multiple injuries, including severe thoracic trauma (AISThorax ≥ 3) between 2010 and 2014. A multivariable binary regression was used to identify predictor variables for tracheostomy and to develop the Tracheostomy in Thoracic Trauma Prediction Score (T3P-Score). The study included 1019 adult thoracic trauma patients, of whom 165 underwent tracheostomy during their intensive care unit (ICU) stay. Prehospital endotracheal intubation (adjusted OR [AOR]: 2.494, 95% CI [1.412; 4.405]), diagnosis of pneumonia during the ICU stay (AOR: 4.374, 95% CI [2.503; 7.642]), duration of mechanical ventilation (AOR: 1.008/hours of intubation, 95% CI [1.006; 1.009]), and an AISHead ≥ 3 (AOR 1.840, 95% CI [1.039; 3.261]) were independent risk factors for tracheostomy. Patients with sepsis had a lower risk of tracheostomy than patients without sepsis (AOR 0.486, 95% CI [0.253; 0.935]). The T3P-Score had high predictive validity for tracheostomy (ROCAUC = 0.938, 95% CI [0.920, 0.956]; Nagelkerke’s R2 was 0.601). The T3P-Score’s specificity was 0.68, and the sensitivity was 0.96. The severity of thoracic trauma did not predict the need for tracheostomy. Follow-up studies should validate the T3P-Score in external data sets and study the reasons for the reluctant use of tracheostomy in patients with severe thoracic trauma and subsequent sepsis. Trial registration : The study was applied for and registered a priori with the respective ethics committees.
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- 2023
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4. Prevalence and outcome of abdominal vascular injury in severe trauma patients based on a TraumaRegister DGU international registry analysis
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Mohammad Esmaeil Barbati, Frank Hildebrand, Hagen Andruszkow, Rolf Lefering, Michael J. Jacobs, Houman Jalaie, and Alexander Gombert
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Medicine ,Science - Abstract
Abstract This study details the etiology, frequency and effect of abdominal vascular injuries in patients after polytrauma based on a large registry of trauma patients. The impact of arterial, venous and mixed vascular injuries on patients’ outcome was of interest, as in particular the relevance of venous vessel injury may be underestimated and not adequately assessed in literature so far. All patients of TraumaRegister DGU with the following criteria were included: online documentation of european trauma centers, age 16–85 years, presence of abdominal vascular injury and Abbreviated Injury Scale (AIS) ≥ 3. Patients were divided in three groups of: arterial injury only, venous injury only, mixed arterial and venous injuries. Reporting in this study adheres to the STROBE criteria. A total of 2949 patients were included. All types of abdominal vessel injuries were more prevalent in patients with abdominal trauma followed by thoracic trauma. Rate of patients with shock upon admission were the same in patients with arterial injury alone (n = 606, 33%) and venous injury alone (n = 95, 32%). Venous trauma showed higher odds ratio for in-hospital mortality (OR: 1.48; 95% CI 1.10–1.98, p = 0.010). Abdominal arterial and venous injury in patients suffering from severe trauma were associated with a comparable rate of hemodynamic instability at the time of admission. 24 h as well as in-hospital mortality rate were similar in in patients with venous injury and arterial injury. Stable patients suspected of abdominal vascular injuries should be further investigated to exclude or localize the possible subtle venous injury.
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- 2021
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5. Lightning IR: Straightforward Fine-tuning and Inference of Transformer-based Language Models for Information Retrieval
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Schlatt, Ferdinand, Fröbe, Maik, and Hagen, Matthias
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Computer Science - Information Retrieval - Abstract
A wide range of transformer-based language models have been proposed for information retrieval tasks. However, fine-tuning and inference of these models is often complex and requires substantial engineering effort. This paper introduces Lightning IR, a PyTorch Lightning-based framework for fine-tuning and inference of transformer-based language models for information retrieval. Lightning IR provides a modular and extensible architecture that supports all stages of an information retrieval pipeline: from fine-tuning and indexing to searching and re-ranking. It is designed to be straightforward to use, scalable, and reproducible. Lightning IR is available as open-source: https://github.com/webis-de/lightning-ir., Comment: Accepted as a demo at WSDM'25
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- 2024
6. Upcycling Human Excrement: The Gut Microbiome to Soil Microbiome Axis
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Meilander, Jeff, Herman, Chloe, Manley, Andrew, Augustine, Georgia, Birdsell, Dawn, Bolyen, Evan, Celona, Kimberly R., Coffey, Hayden, Cocking, Jill, Donoghue, Teddy, Draves, Alexis, Erickson, Daryn, Foley, Marissa, Gehret, Liz, Hagen, Johannah, Hepp, Crystal, Ingram, Parker, John, David, Kadar, Katarina, Keim, Paul, Lloyd, Victoria, Osterink, Christina, Queeney, Victoria, Ramirez, Diego, Romero, Antonio, Ruby, Megan C., Sahl, Jason W., Soloway, Sydni, Stone, Nathan E., Trottier, Shannon, Van Orden, Kaleb, Painter, Alexis, Wallace, Sam, Wilcox, Larissa, Wood, Colin V., Yancey, Jaiden, and Caporaso, J. Gregory
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Quantitative Biology - Genomics - Abstract
Human excrement composting (HEC) is a sustainable strategy for human excrement (HE) management that recycles nutrients and mitigates health risks while reducing reliance on freshwater, fossil fuels, and fertilizers. We present a comprehensive microbial time series analysis of HEC and show that the initial gut-like microbiome of HEC systems transitions to a microbiome similar to soil and traditional compost in fifteen biological replicates tracked weekly for one year., Comment: Main text: 9 pages, 2 figures; Extended data: 10 figures; Supplemental Text: 32 pages, 8 figures, 2 tables
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- 2024
7. A wiggling filamentary jet at the origin of the blazar multi-wavelength behaviour
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Raiteri, C. M., Villata, M., Carnerero, M. I., Kurtanidze, S. O., Mirzaqulov, D. O., Benítez, E., Bonnoli, G., Carosati, D., Acosta-Pulido, J. A., Agudo, I., Andreeva, T. S., Apolonio, G., Bachev, R., Borman, G. A., Bozhilov, V., Brown, L. F., Carbonell, W., Casadio, C., Chen, W. P., Damljanovic, G., Ehgamberdiev, S. A., Elsaesser, D., Escudero, J., Feige, M., Fuentes, A., Gabellini, D., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Hagen-Thorn, V. A., Hamed, G. M., Hiriart, D., Hodges, M., ivanidze, R. Z., Ivanov, D. V., Joner, M. D., Jorstad, S. G., Jovanovic, M. D., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kovalev, Yu. A., Kovalev, Y. Y., Kurtanidze, O. M., Kurtenkov, A., Larionova, E. G., Lessing, A., Lin, H. C., López, J. M., Lorey, C., Ludwig, J., Marchili, N., Marchini, A., Marscher, A. P., Matsumoto, K., Max-Moerbeck, W., Mihov, B., Minev, M., Mingaliev, M. G., Modaressi, A., Morozova, D. A., Mortari, F., Mufakharov, T. V., Myserlis, I., Nikolashvili, M. G., Pearson, T. J., Popkov, A. V., Rahimov, I. A., Readhead, A. C. S., Reinhart, D., Reeves, R., Righini, S., Romanov, F. D., Savchenko, S. S., Semkov, E., Shishkina, E. V., Sigua, L. A., Slavcheva-Mihova, L., Sotnikova, Yu. V., Steineke, R., Stojanovic, M., Strigachev, A., Takey, A., Traianou, E., Troitskaya, Yu. V., Troitskiy, I. S., Tsai, A. L., Valcheva, A., Vasilyev, A. A., Verna, G., Vince, O., Vrontaki, K., Weaver, Z. R., Webb, J., Yuldoshev, Q. X., Zaharieva, E., and Zhovtan, A. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Blazars are beamed active galactic nuclei known for their strong multi-wavelength variability on timescales from years down to minutes. We aim to investigate the suitability of the twisting jet model presented in previous works to explain the multi-wavelength behaviour of BL Lacertae, the prototype of one of the blazar classes. According to this model, the jet is inhomogeneous, curved, and twisting, and the long-term variability is due to changes in the Doppler factor due to variations in the orientation of the jet-emitting regions. We analysed optical data of the source obtained during monitoring campaigns organised by the Whole Earth Blazar Telescope (WEBT) in 2019-2022, together with radio data from the WEBT and other teams, and gamma-ray data from the Fermi satellite. In this period, BL Lacertae underwent an extraordinary activity phase, reaching its historical optical and gamma-ray brightness maxima. The application of the twisting jet model to the source light curves allows us to infer the wiggling motion of the optical, radio, and gamma-ray jet-emitting regions. The optical-radio correlation shows that the changes in the radio viewing angle follow those in the optical viewing angle by about 120 days, and it suggests that the jet is composed of plasma filaments, which is in agreement with some radio high-resolution observations of other sources. The gamma-ray emitting region is found to be co-spatial with the optical one, and the analysis of the gamma-optical correlation is consistent with both the geometric interpretation and a synchrotron self-Compton (SSC) origin of the high-energy photons. We propose a geometric scenario where the jet is made up of a pair of emitting plasma filaments in a sort of double-helix curved rotating structure, whose wiggling motion produces changes in the Doppler beaming and can thus explain the observed multi-wavelength long-term variability., Comment: In press for A&A
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- 2024
8. The Local Ultraviolet to Infrared Treasury I. Survey Overview of the Broadband Imaging
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Gilbert, Karoline M., Choi, Yumi, Boyer, Martha L., Williams, Benjamin F., Weisz, Daniel R., Bell, Eric F., Dalcanton, Julianne J., McQuinn, Kristen B. W., Skillman, Evan D., Costa, Guglielmo, Fouesneau, Morgan, Girardi, Léo, Goldman, Steven R., Gordon, Karl D., Guhathakurta, Puragra, Gull, Maude, Hagen, Lea, Huynh, Ky, Lindberg, Christina W., Marigo, Paola, Murray, Claire E., Pastorelli, Giada, and Merica-Jones, Petia Yanchulova
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Astrophysics - Astrophysics of Galaxies - Abstract
The Local Ultraviolet to Infrared Treasury (LUVIT) is a Hubble Space Telescope program that combines newly acquired data in the near ultraviolet (NUV), optical, and near infrared (NIR) with archival optical and NIR imaging to produce multiband panchromatic resolved stellar catalogs for 23 pointings in 22 low-mass, star-forming galaxies ranging in distance from the outskirts of the Local Group to ~3.8 Mpc. We describe the survey design, detail the LUVIT broadband filter observations and the archival datasets included in the LUVIT reductions, and summarize the simultaneous multiband data reduction steps. The spatial distributions and color-magnitude diagrams (CMDs) from the resulting stellar catalogs are presented for each target, from the NUV to the NIR. We demonstrate in which regions of the CMDs stars with NUV and optical, optical and NIR, and NUV through NIR detections reside. For each target, we use the results from artificial star tests to measure representative completeness, bias, and total photometric uncertainty as a function of magnitude in each broadband filter. We also assess which LUVIT targets have significant spatial variation in the fraction of stars recovered at a given magnitude. The panchromatic LUVIT stellar catalogs will provide a rich legacy dataset for a host of resolved stellar population studies., Comment: 48 pages, 14 figures, 8 tables, accepted for publication in ApJS
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- 2024
9. A Two-Week $IXPE$ Monitoring Campaign on Mrk 421
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Maksym, W. Peter, Liodakis, Ioannis, Saade, M. Lynne, Kim, Dawoon E., Middei, Riccardo, Di Gesu, Laura, Kiehlmann, Sebastian, Matzeu, Gabriele, Agudo, Iván, Marscher, Alan P., Ehlert, Steven R., Jorstad, Svetlana G., Kaaret, Philip, Marshall, Herman L., Pacciani, Luigi, Perri, Matteo, Puccetti, Simonetta, Kouch, Pouya M., Lindfors, Elina, Aceituno, Francisco José, Bonnoli, Giacomo, Casanova, Víctor, Escudero, Juan, Agís-González, Beatriz, Husillos, César, Morcuende, Daniel, Otero-Santos, Jorge, Sota, Alfredo, Piirola, Vilppu, Imazawa, Ryo, Sasada, Mahito, Fukazawa, Yasushi, Kawabata, Koji S., Uemura, Makoto, Mizuno, Tsunefumi, Nakaoka, Tatsuya, Akitaya, Hiroshi, McCall, Callum, Jermak, Helen E., Steele, Iain A., Borman, George A., Grishina, Tatiana S., Hagen-Thorn, Vladimir A., Kopatskaya, Evgenia N., Larionova, Elena G., Morozova, Daria A., Savchenko, Sergey S., Shishkina, Ekaterina V., Troitskiy, Ivan S., Troitskaya, Yulia V., Vasilyev, Andrey A., Zhovtan, Alexey V., Myserlis, Ioannis, Gurwell, Mark, Keating, Garrett, Rao, Ramprasad, Pauley, Colt, Angelakis, Emmanouil, Kraus, Alexander, Berdyugin, Andrei V., Kagitani, Masato, Kravtsov, Vadim, Poutanen, Juri, Sakanoi, Takeshi, Kang, Sincheol, Lee, Sang-Sung, Kim, Sang-Hyun, Cheong, Whee Yeon, Jeong, Hyeon-Woo, Song, Chanwoo, Blinov, Dmitry, Shablovinskaya, Elena, Antonelli, Lucio Angelo, Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccoló, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccoló, Di Marco, Alessandro, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel Lawrence, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgró, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
X-ray polarization is a unique new probe of the particle acceleration in astrophysical jets made possible through the Imaging X-ray Polarimetry Explorer. Here we report on the first dense X-ray polarization monitoring campaign on the blazar Mrk 421. Our observations were accompanied by an even denser radio and optical polarization campaign. We find significant short-timescale variability in both X-ray polarization degree and angle, including a $\sim90^\circ$ angle rotation about the jet axis. We attribute this to random variations of the magnetic field, consistent with the presence of turbulence but also unlikely to be explained by turbulence alone. At the same time, the degree of lower-energy polarization is significantly lower and shows no more than mild variability. Our campaign provides further evidence for a scenario in which energy-stratified shock-acceleration of relativistic electrons, combined with a turbulent magnetic field, is responsible for optical to X-ray synchrotron emission in blazar jets., Comment: 23 pages, including 8 pages of appendices. 12 figures, 3 tables. Submitted to ApJ
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- 2024
10. Recent advances in coupled cluster computations of open-shell atomic nuclei
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Marino, Francesco, Bonaiti, Francesca, Bacca, Sonia, Hagen, Gaute, Jansen, Gustav, and Tichai, Alexander
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Nuclear Theory - Abstract
In this contribution, we report on recent progress in coupled-cluster simulations of open-shell atomic nuclei using interactions consistently derived from chiral effective field theory. In particular, we compare different coupled-cluster approaches by computing binding energies and electric dipole polarizabilities in medium-mass calcium isotopes., Comment: Proceeding of "Nuclear Structure and Dynamics - NSD 2024". Summitted to EPJ Web of Conferences
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- 2024
11. SYNOSIS: Image synthesis pipeline for machine vision in metal surface inspection
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Fulir, Juraj, Jeziorski, Natascha, Bosnar, Lovro, Hagen, Hans, Redenbach, Claudia, Gospodnetić, Petra, Herrfurth, Tobias, Trost, Marcus, and Gischkat, Thomas
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Computational Engineering, Finance, and Science ,Computer Science - Graphics ,I.2.1 ,I.2.10 ,I.4.6 ,I.4.9 ,I.4.7 ,I.3.8 ,I.3.6 ,I.3.5 ,I.3.7 ,I.5.4 ,J.6 ,J.7 - Abstract
The use of machine learning (ML) methods for development of robust and flexible visual inspection system has shown promising. However their performance is highly dependent on the amount and diversity of training data. This is often restricted not only due to costs but also due to a wide variety of defects and product surfaces which occur with varying frequency. As such, one can not guarantee that the acquired dataset contains enough defect and product surface occurrences which are needed to develop a robust model. Using parametric synthetic dataset generation, it is possible to avoid these issues. In this work, we introduce a complete pipeline which describes in detail how to approach image synthesis for surface inspection - from first acquisition, to texture and defect modeling, data generation, comparison to real data and finally use of the synthetic data to train a defect segmentation model. The pipeline is in detail evaluated for milled and sandblasted aluminum surfaces. In addition to providing an in-depth view into each step, discussion of chosen methods, and presentation of ML results, we provide a comprehensive dual dataset containing both real and synthetic images., Comment: Initial preprint, 21 pages, 21 figures, 6 tables
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- 2024
12. Automated Model Discovery for Tensional Homeostasis: Constitutive Machine Learning in Growth and Remodeling
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Holthusen, Hagen, Brepols, Tim, Linka, Kevin, and Kuhl, Ellen
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Computer Science - Machine Learning ,Condensed Matter - Materials Science ,Computer Science - Computational Engineering, Finance, and Science ,65, 74 ,I.6 ,J.2 - Abstract
Soft biological tissues exhibit a tendency to maintain a preferred state of tensile stress, known as tensional homeostasis, which is restored even after external mechanical stimuli. This macroscopic behavior can be described using the theory of kinematic growth, where the deformation gradient is multiplicatively decomposed into an elastic part and a part related to growth and remodeling. Recently, the concept of homeostatic surfaces was introduced to define the state of homeostasis and the evolution equations for inelastic deformations. However, identifying the optimal model and material parameters to accurately capture the macroscopic behavior of inelastic materials can only be accomplished with significant expertise, is often time-consuming, and prone to error, regardless of the specific inelastic phenomenon. To address this challenge, built-in physics machine learning algorithms offer significant potential. In this work, we extend our inelastic Constitutive Artificial Neural Networks (iCANNs) by incorporating kinematic growth and homeostatic surfaces to discover the scalar model equations, namely the Helmholtz free energy and the pseudo potential. The latter describes the state of homeostasis in a smeared sense. We evaluate the ability of the proposed network to learn from experimentally obtained tissue equivalent data at the material point level, assess its predictive accuracy beyond the training regime, and discuss its current limitations when applied at the structural level. Our source code, data, examples, and an implementation of the corresponding material subroutine are made accessible to the public at https://doi.org/10.5281/zenodo.13946282., Comment: 46 pages, 12 figures, 5 tables
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- 2024
13. Systematic collapse of the accretion disc in AGN confirmed by UV photometry and broad line spectra
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Kang, Jia-Lai, Done, Chris, Hagen, Scott, Temple, Matthew J., Silverman, John D., Li, Junyao, and Liu, Teng
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
A recent study on the spectral energy distribution (SED) of AGN combined unobscured X-ray sources from the eROSITA eFEDS Survey with high quality optical imaging from Subaru's Hyper Suprime-Cam (HSC). The HSC data enabled accurate host galaxy subtraction as well as giving a uniform black hole mass estimator from the stellar mass. The resulting stacked optical/X-ray SEDs for black holes at fixed mass show a dramatic transition, where the dominating disc component in bright AGN evaporates into an X-ray hot plasma below $L/L_{\rm Edd}\sim 0.01$. The models fit to these datasets predicted the largest change in SED in the rest frame UV ($< 3000\,\r{A}$), but this waveband was not included in the original study. Here we use archival $u$-band and UV photometry to extend the SEDs into this range, and confirm the UV is indeed intrinsically faint in AGN below $L/L_{\rm Edd}\sim 0.01$ as predicted. This dramatic drop in UV photo-ionising flux is also seen from its effect on the broad emission lines. We stack the recently released SDSS DR18 optical spectra for this sample, and show that the broad H$\beta$ line disappears along with the UV bright component at $L/L_{\rm Edd}\sim 0.01$. This shows that there is a population of unobscured, X-ray bright, UV faint AGN which lack broad emission lines (true type 2 Seyferts)., Comment: 10 pages, 3 figure, 2 appendices. Submitted to MNRAS. Comments are very welcome!
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- 2024
14. 16O electroweak response functions from first principles
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Acharya, Bijaya, Sobczyk, Joanna E., Bacca, Sonia, Hagen, Gaute, and Jiang, Weiguang
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Nuclear Theory - Abstract
We present calculations of various electroweak response functions for the 16O nucleus obtained using coupled-cluster theory in conjunction with the Lorentz integral transform method. We employ nuclear forces derived at next-to-leading order and next-to-next-to-leading order in chiral effective field theory and perform a Bayesian analysis to assess uncertainties. Our results are in good agreement with available electron-scattering data at q~ 326 MeV/c. Additionally, we provide several predictions for the weak response functions in the quasi-elastic peak region at q= 300 and 400 MeV/c, which are critical for long-baseline neutrino experiments.
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- 2024
15. Sharp conditional moment bounds for products of $L$-functions
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Hagen, Markus Valås
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Mathematics - Number Theory - Abstract
Assuming the Generalized Riemann Hypothesis and the Generalized Ramanujan Conjecture, we determine the order of the $2(k_1,\dots,k_r)$th moment of a product of distinct irreducible $L$-functions on the critical line. As a consequence, we obtain conditional information about the independence of these $L$-functions in the large deviations regime. We also obtain sharp moment bounds for Hurwitz zeta functions with rational parameter, and a certain family of Dedekind zeta functions., Comment: 33 pages
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- 2024
16. Improving generalisability of 3D binding affinity models in low data regimes
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Buhmann, Julia, Haddadin, Ward, Pravda, Lukáš, Bilsland, Alan, and Triendl, Hagen
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Predicting protein-ligand binding affinity is an essential part of computer-aided drug design. However, generalisable and performant global binding affinity models remain elusive, particularly in low data regimes. Despite the evolution of model architectures, current benchmarks are not well-suited to probe the generalisability of 3D binding affinity models. Furthermore, 3D global architectures such as GNNs have not lived up to performance expectations. To investigate these issues, we introduce a novel split of the PDBBind dataset, minimizing similarity leakage between train and test sets and allowing for a fair and direct comparison between various model architectures. On this low similarity split, we demonstrate that, in general, 3D global models are superior to protein-specific local models in low data regimes. We also demonstrate that the performance of GNNs benefits from three novel contributions: supervised pre-training via quantum mechanical data, unsupervised pre-training via small molecule diffusion, and explicitly modeling hydrogen atoms in the input graph. We believe that this work introduces promising new approaches to unlock the potential of GNN architectures for binding affinity modelling., Comment: 17 pages, 10 figues
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- 2024
17. Photon Number Coherence in Quantum Dot-Cavity Systems can be Enhanced by Phonons
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Hagen, Paul C. A., Bozzio, Mathieu, Cygorek, Moritz, Reiter, Doris E., and Axt, Vollrath M.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Semiconductor quantum dots are a versatile source of single photons with tunable properties to be used in quantum-cryptographic applications. A crucial figure of merit of the emitted photons is photon number coherence (PNC), which impacts the security of many quantum communication protocols. In the process of single-photon generation, the quantum dot as a solid-state object is subject to an interaction with phonons, which can therefore indirectly affect the PNC. In this paper, we elaborate on the origin of PNC in optically excited quantum dots and how it is affected by phonons. In contrast to the expectation that phonons always deteriorate coherence, PNC can be increased in a quantum dot-cavity system due to the electron-phonon interaction.
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- 2024
18. Structure of odd-mass Ne, Na, and Mg nuclei
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Sun, Z. H., Djärv, T. R., Hagen, G., Jansen, G. R., and Papenbrock, T.
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Nuclear Theory - Abstract
The island of inversion is a region of neutron-rich nuclei that are deformed in their ground states. In this region, less is known about the energy levels of odd-mass nuclei, how they evolve with increasing neutron numbers, and how they can be organized into rotational bands. We perform {\it ab initio} coupled-cluster calculations of spectra in odd-mass Ne, Na, and Mg nuclei based on an interaction of chiral effective field theory. Our results confirm some tentative spin and parity assignments, predict the structure of nuclei near the neutron dripline, and inform us about rotational bands in this region of the nuclear table., Comment: 12 pages, 9 figures
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- 2024
19. Impact of anticoagulation and antiplatelet drugs on surgery rates and mortality in trauma patients
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Felix M. Bläsius, Markus Laubach, Hagen Andruszkow, Cavan Lübke, Philipp Lichte, Rolf Lefering, Frank Hildebrand, and Klemens Horst
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Medicine ,Science - Abstract
Abstract Preinjury anticoagulation therapy (AT) is associated with a higher risk for major bleeding. We aimed to evaluated the influence of preinjury anticoagulant medication on the clinical course after moderate and severe trauma. Patients in the TraumaRegister DGU ≥ 55 years who received AT were matched with patients not receiving AT. Pairs were grouped according to the drug used: Antiplatelet drugs (APD), vitamin K antagonists (VKA) and direct oral anticoagulants (DOAC). The primary end points were early (
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- 2021
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20. The Effects of Morphological Instruction on Literacy Outcomes for Children in English-Speaking Countries: A Systematic Review and Meta-Analysis
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Danielle Colenbrander, Alexa von Hagen, Saskia Kohnen, Signy Wegener, Katherine Ko, Elisabeth Beyersmann, Ali Behzadnia, Rauno Parrila, and Anne Castles
- Abstract
In this pre-registered meta-analysis, we investigated the effectiveness of morphology instruction on literacy outcomes for primary school children in English-speaking countries. We were interested in overall reading and spelling outcomes, but we also looked separately at results for trained and untrained words in order to determine whether there was evidence of transfer to untrained words. Further, we were interested in whether results transferred beyond the word level to reading comprehension outcomes. Our screening process revealed 28 eligible studies, which contributed 177 effect sizes to the analyses. Robust variance estimation methods were used to account for dependence between effect sizes. Overall, effect sizes on reading and spelling outcomes were small to moderate. Effect sizes were larger for trained words than untrained words. There was evidence of transfer to untrained words for spelling outcomes, but not for reading outcomes. There was also no clear evidence of effects on reading comprehension outcomes. In general, the evidence was characterised by large amounts of heterogeneity and imprecision, which was reflective of the wide variety within and between studies in terms of intervention content, outcome measures, intervention dosage and type of control group. We discuss the limitations of the current literature and make recommendations for future research and practice in the field of morphology instruction.
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- 2024
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21. Scope of School Psychological Practice in Germany: Part 1
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Alexa von Hagen, Bettina Müller, Natalie Vannini, Nils Rublevskis, Mirijam Schaaf, Stephan Jeck, Marion Müller-Staske, Gerhard Bachmann, Anna Sedlak, Joanna Wegerer, and Gerhard Büttner
- Abstract
Many countries rely on statements issued by professional associations to delimit the scope of school psychological practice. It is, however, not always clear to what extent these statements match current practices and school psychologists' self-perception of their professional role, as empirical data is often unavailable or limited. This study aims to address this gap by collecting empirical data on the scope of school psychological practice in Germany. In a mixed method study, we first applied the Delphi technique to develop a questionnaire in collaboration with school psychological experts from different federal states of Germany. Second, we collected information on federal policies through semi-structured interviews with regional experts. Third, we invited a representative sample of school psychologists to complete the questionnaire developed through the Delphi technique. In this first report, we focus on the Delphi procedure and overall results of the survey describing the scope of school psychological practice in Germany at a country-wide level. These findings provide a detailed characterization of the broad and heterogeneous scope providing an evidence-base for future research and political decision-making.
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- 2024
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22. Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant.
- Author
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van den Bosch, Jacqueline, Pennisi, Vincenzo, Rao, Harsha, Mansouri, Kaweh, Weinreb, Robert, Thieme, Hagen, Hoffmann, Michael, and Choritz, Lars
- Subjects
glaucoma ,intraocular pressure ,telemedicine ,Humans ,Intraocular Pressure ,Glaucoma ,Open-Angle ,Reproducibility of Results ,Tonometry ,Ocular ,Female ,Male ,Telemetry ,Aged ,Middle Aged ,Circadian Rhythm ,Glaucoma Drainage Implants ,Aged ,80 and over - Abstract
BACKGROUND: Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring. METHODS: Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements throughout 24 hours on two consecutive days (day 1 and day 2). Patients wore an antenna adjacent to the study eye connected to a reader device to record IOP every 5 min. Also, self-measurements in six of seven patients were collected for a period of 30 days. Analysis included calculation of hourly averages to correlate time-pairs of day 1 versus day 2 and the self-measurements vers day 2. RESULTS: The number of IOP measurements per patient ranged between 151 and 268 on day 1, 175 and 268 on day 2 and 19 and 1236 during 30 days of self-measurements. IOP time-pairs of automatic measurements on day 1 and day 2 were significantly correlated at the group level (R=0.83, p
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- 2024
23. An Eddington Limited Accretion Disk Wind in the narrow line Seyfert 1, PG 1448+273
- Author
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Reeves, J. N., Braito, V., Luminari, A., Porquet, D., Laurenti, M., Matzeu, G., Lobban, A., and Hagen, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
PG 1448+273 is a luminous, nearby ($z=0.0645$), narrow line Seyfert 1 galaxy, which likely accretes close to the Eddington limit. Previous X-ray observations of PG 1448 with XMM-Newton in 2017 and NuSTAR in 2022 revealed the presence of an ultra fast outflow, as seen through its blueshifted iron K absorption profile, where the outflow velocity appeared to vary in the range $0.1-0.3c$. In this work, new X-ray observations of PG 1448 are presented, in the form of four simultaneous XMM-Newton and NuSTAR observations performed in July and August 2023. The X-ray spectra appeared at a similar flux in each observation, making it possible to analyze the mean 2023 X-ray spectrum at high signal to noise. A broad ($\sigma=1$ keV) and highly blue-shifted ($E=9.8\pm0.4$ keV) iron K absorption profile is revealed in the mean spectrum. The profile can be modeled by a fast, geometrically thick accretion disk wind, which reveals a maximum terminal velocity of $v_{\infty}=-0.43\pm0.03c$, one of the fastest known winds in a nearby AGN. As a result, the inferred mass outflow rate of the wind may reach a significant fraction of the Eddington accretion rate., Comment: 15 pages, accepted for publication in the Astrophysical Journal
- Published
- 2024
24. Wav2Small: Distilling Wav2Vec2 to 72K parameters for Low-Resource Speech emotion recognition
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Kounadis-Bastian, Dionyssos, Schrüfer, Oliver, Derington, Anna, Wierstorf, Hagen, Eyben, Florian, Burkhardt, Felix, and Schuller, Björn
- Subjects
Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Speech Emotion Recognition (SER) needs high computational resources to overcome the challenge of substantial annotator disagreement. Today SER is shifting towards dimensional annotations of arousal, dominance, and valence (A/D/V). Universal metrics as the L2 distance prove unsuitable for evaluating A/D/V accuracy due to non converging consensus of annotator opinions. However, Concordance Correlation Coefficient (CCC) arose as an alternative metric for A/D/V where a model's output is evaluated to match a whole dataset's CCC rather than L2 distances of individual audios. Recent studies have shown that wav2vec2 / wavLM architectures outputing a float value for each A/D/V dimension achieve today's State-of-the-art (Sota) CCC on A/D/V. The Wav2Vec2.0 / WavLM family has a high computational footprint, but training small models using human annotations has been unsuccessful. In this paper we use a large Transformer Sota A/D/V model as Teacher/Annotator to train 5 student models: 4 MobileNets and our proposed Wav2Small, using only the Teacher's A/D/V outputs instead of human annotations. The Teacher model we propose also sets a new Sota on the MSP Podcast dataset of valence CCC=0.676. We choose MobileNetV4 / MobileNet-V3 as students, as MobileNet has been designed for fast execution times. We also propose Wav2Small - an architecture designed for minimal parameters and RAM consumption. Wav2Small with an .onnx (quantised) of only 120KB is a potential solution for A/D/V on hardware with low resources, having only 72K parameters vs 3.12M parameters for MobileNet-V4-Small., Comment: Nomenclature
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- 2024
25. Ab initio computations from $^{78}$Ni towards $^{70}$Ca along neutron number $N=50$
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Hu, B. S., Sun, Z. H., Hagen, G., Jansen, G. R., and Papenbrock, T.
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Nuclear Theory ,Nuclear Experiment - Abstract
We present coupled-cluster computations of nuclei with neutron number $N=50$ "south" of $^{78}$Ni using nucleon-nucleon and three-nucleon forces from chiral effective field theory. We find an erosion of the magic number $N=50$ toward $^{70}$Ca manifesting itself by an onset of deformation and increased complexity in the ground states. For $^{78}$Ni, we predict a low-lying rotational band consistent with recent data, which up until now has been a challenge for ab initio nuclear models. Ground states are deformed in $^{76}$Fe, $^{74}$Cr, and $^{72}$Ti, although the spherical states are too close in energy to unambiguously identify the shape of the ground state within the uncertainty estimates. In $^{70}$Ca, the potential energy landscape from quadrupole-constrained Hartree-Fock computations flattens, and the deformation becomes less rigid. We also compute the low-lying spectra and $B({\rm E2})$ values for these neutron-rich $N=50$ nuclei., Comment: 10 pages, 6 figures, supplementary material
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- 2024
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26. An anisotropic, brittle damage model for finite strains with a generic damage tensor regularization
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van der Velden, Tim, Reese, Stefanie, Holthusen, Hagen, and Brepols, Tim
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Computer Science - Computational Engineering, Finance, and Science - Abstract
This paper establishes a universal framework for the nonlocal modeling of anisotropic damage at finite strains. By the combination of two recent works, the new framework allows for the flexible incorporation of different established hyperelastic finite strain material formulations into anisotropic damage whilst ensuring mesh-independent results by employing a generic set of micromorphic gradient-extensions. First, the anisotropic damage model, generally satisfying the damage growth criterion, is investigated for the specific choice of a Neo-Hookean material on a single element. Next, the model is applied with different gradient-extensions in structural simulations of an asymmetrically notched specimen to identify an efficient choice in the form of a volumetric-deviatoric regularization. Thereafter, the universal framework, which is without loss of generality here specified for a Neo-Hookean material with a volumetric-deviatoric gradient-extension, successfully serves for the complex simulation of a pressure loaded rotor blade. After acceptance of the manuscript, we make the codes of the material subroutines accessible to the public at https://doi.org/10.5281/zenodo.11171630.
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- 2024
27. Moving past point-contacts: Extending the ALIP model to humanoids with non-trivial feet using hierarchical, full-body momentum control
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Paredes, Victor C., Hagen, Daniel A., Chesebrough, Samuel W., Swann, Riley, Garagic, Denis, and Hereid, Ayonga
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Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control - Abstract
The Angular-Momentum Linear Inverted Pendulum (ALIP) model is a promising motion planner for bipedal robots. However, it relies on two assumptions: (1) the robot has point-contact feet or passive ankles, and (2) the angular momentum around the center of mass, known as centroidal angular momentum, is negligible. This paper addresses the question of whether the ALIP paradigm can be applied to more general bipedal systems with complex foot geometry (e.g., flat feet) and nontrivial torso/limb inertia and mass distribution (e.g., non-centralized arms). In such systems, the dynamics introduce non-negligible centroidal momentum and contact wrenches at the feet, rendering the assumptions of the ALIP model invalid. This paper presents the ALIP planner for general bipedal robots with non-point-contact feet through the use of a task-space whole-body controller that regulates centroidal momentum, thereby ensuring that the robot's behavior aligns with the desired template dynamics. To demonstrate the effectiveness of our proposed approach, we conduct simulations using the Sarcos Guardian XO robot, which is a hybrid humanoid/exoskeleton with large, offset feet. The results demonstrate the practicality and effectiveness of our approach in achieving stable and versatile bipedal locomotion., Comment: 7 pages, 9 figures
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- 2024
28. Advancing oncology with federated learning: transcending boundaries in breast, lung, and prostate cancer. A systematic review
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Ankolekar, Anshu, Boie, Sebastian, Abdollahyan, Maryam, Gadaleta, Emanuela, Hasheminasab, Seyed Alireza, Yang, Guang, Beauville, Charles, Dikaios, Nikolaos, Kastis, George Anthony, Bussmann, Michael, Khalid, Sara, Kruger, Hagen, Lambin, Philippe, and Papanastasiou, Giorgos
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computational Engineering, Finance, and Science ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Federated Learning (FL) has emerged as a promising solution to address the limitations of centralised machine learning (ML) in oncology, particularly in overcoming privacy concerns and harnessing the power of diverse, multi-center data. This systematic review synthesises current knowledge on the state-of-the-art FL in oncology, focusing on breast, lung, and prostate cancer. Distinct from previous surveys, our comprehensive review critically evaluates the real-world implementation and impact of FL on cancer care, demonstrating its effectiveness in enhancing ML generalisability, performance and data privacy in clinical settings and data. We evaluated state-of-the-art advances in FL, demonstrating its growing adoption amid tightening data privacy regulations. FL outperformed centralised ML in 15 out of the 25 studies reviewed, spanning diverse ML models and clinical applications, and facilitating integration of multi-modal information for precision medicine. Despite the current challenges identified in reproducibility, standardisation and methodology across studies, the demonstrable benefits of FL in harnessing real-world data and addressing clinical needs highlight its significant potential for advancing cancer research. We propose that future research should focus on addressing these limitations and investigating further advanced FL methods, to fully harness data diversity and realise the transformative power of cutting-edge FL in cancer care., Comment: 5 Figures, 3 Tables, 1 Supplementary Table
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- 2024
29. Geometric phase evolution
- Author
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Hagen, Nathan and Garza-Soto, Luis
- Subjects
Physics - Optics ,Physics - Classical Physics - Abstract
Geometric phase has historically been defined using closed cycles of polarization states, often derived using differential geometry on the Poincare sphere. Using the recently-developed wave model of geometric phase, we show that it is better to define geometric phase more generally, allowing every polarized wave to have a well-defined value at any point in its path. Using several example systems, we show how this approach provides more insight into the wave's behavior. Moreover, by tracking the continuous evolution of geometric phase as a wave propagates through an optical system, we encounter a natural explanation of why the conventional Poincare sphere solid angle method uses geodesic paths rather than physical paths of the polarization state.
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- 2024
30. Accounting for plasticity: An extension of inelastic Constitutive Artificial Neural Networks
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Boes, Birte, Simon, Jaan-Willem, and Holthusen, Hagen
- Subjects
Computer Science - Machine Learning - Abstract
The class of Constitutive Artificial Neural Networks (CANNs) represents a new approach of neural networks in the field of constitutive modeling. So far, CANNs have proven to be a powerful tool in predicting elastic and inelastic material behavior. However, the specification of inelastic constitutive artificial neural networks (iCANNs) to capture plasticity remains to be discussed. We present the extension and application of an iCANN to the inelastic phenomena of plasticity. This includes the prediction of a formulation for the elastic and plastic Helmholtz free energies, the inelastic flow rule, and the yield condition that defines the onset of plasticity. Thus, we learn four feed-forward networks in combination with a recurrent neural network and use the second Piola-Kirchhoff stress measure for training. The presented formulation captures both, associative and non-associative plasticity. In addition, the formulation includes kinematic hardening effects by introducing the plastic Helmholtz free energy. This opens the range of application to a wider class of materials. The capabilities of the presented framework are demonstrated by training on artificially generated data of models for perfect plasticity of von-Mises type, tension-compression asymmetry, and kinematic hardening. We observe already satisfactory results for training on one load case only while extremely precise agreement is found for an increase in load cases. In addition, the performance of the specified iCANN was validated using experimental data of X10CrMoVNb9-1 steel. Training has been performed on both, uniaxial tension and cyclic loading, separately and the predicted results are then validated on the opposing set. The results underline that the autonomously discovered material model is capable to describe and predict the underlying experimental data., Comment: 44 pages, 12 figures, 7 tables
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- 2024
31. Decision-Based vs. Distribution-Driven Clustering for Stochastic Energy System Design Optimization
- Author
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Jürgens, Boyung, Seele, Hagen, Schricker, Hendrik, Reinert, Christiane, and von der Assen, Niklas
- Subjects
Mathematics - Optimization and Control - Abstract
Stochastic programming is widely used for energy system design optimization under uncertainty but can exponentially increase the computational complexity with the number of scenarios. Common scenario reduction techniques, like moments-matching or distribution-driven clustering, pre-select representative scenarios based on input parameters. In contrast, decision-based clustering groups scenarios by similarity in resulting model decisions. Decision-based clustering has shown potential in network design and fleet planning. However, its potential in energy system design remains unexplored. In our work, we examine the effectiveness of decision-based clustering in energy system design using a four-step method: 1) Determine the optimal design for each scenario; 2) Aggregate and normalize installed capacities as features reflecting optimal decisions; 3) Use these features for k-medoids clustering to identify representative scenarios; 4) Utilize these scenarios to optimize cost in stochastic programming. We apply our method to a real-world industrial energy system modeled as a mixed-integer linear program. We incorporate uncertainty by scaling time series with representative factors. We generate 500 single-year scenarios via Monte Carlo sampling, which we reduce using decision-based clustering. For benchmarking, we conduct distribution-driven k-medoids clustering based on the representative factors. In our case studies, both clustering methods yield designs with similar cost efficiency, although decision-based clustering requires substantially more computational resources. To our knowledge, this is the first application of decision-based clustering on energy system design optimization. Future research should investigate the conditions under which decision-based clustering yields more cost-efficient designs compared to distribution-driven clustering., Comment: 6 pages, 3 figures, submitted to Annual International Conference of the German Operations Research Society (GOR) 2024
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- 2024
32. Systematic Evaluation of Neural Retrieval Models on the Touch\'e 2020 Argument Retrieval Subset of BEIR
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Thakur, Nandan, Bonifacio, Luiz, Fröbe, Maik, Bondarenko, Alexander, Kamalloo, Ehsan, Potthast, Martin, Hagen, Matthias, and Lin, Jimmy
- Subjects
Computer Science - Information Retrieval - Abstract
The zero-shot effectiveness of neural retrieval models is often evaluated on the BEIR benchmark -- a combination of different IR evaluation datasets. Interestingly, previous studies found that particularly on the BEIR subset Touch\'e 2020, an argument retrieval task, neural retrieval models are considerably less effective than BM25. Still, so far, no further investigation has been conducted on what makes argument retrieval so "special". To more deeply analyze the respective potential limits of neural retrieval models, we run a reproducibility study on the Touch\'e 2020 data. In our study, we focus on two experiments: (i) a black-box evaluation (i.e., no model retraining), incorporating a theoretical exploration using retrieval axioms, and (ii) a data denoising evaluation involving post-hoc relevance judgments. Our black-box evaluation reveals an inherent bias of neural models towards retrieving short passages from the Touch\'e 2020 data, and we also find that quite a few of the neural models' results are unjudged in the Touch\'e 2020 data. As many of the short Touch\'e passages are not argumentative and thus non-relevant per se, and as the missing judgments complicate fair comparison, we denoise the Touch\'e 2020 data by excluding very short passages (less than 20 words) and by augmenting the unjudged data with post-hoc judgments following the Touch\'e guidelines. On the denoised data, the effectiveness of the neural models improves by up to 0.52 in nDCG@10, but BM25 is still more effective. Our code and the augmented Touch\'e 2020 dataset are available at \url{https://github.com/castorini/touche-error-analysis}., Comment: SIGIR 2024 (Resource & Reproducibility Track)
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- 2024
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33. Revealing the burning and soft heart of the bright bare AGN ESO 141-G55: X-ray broadband and SED analysis
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Porquet, Delphine, Reeves, James N., Hagen, Scott, Lobban, Andrew, Braito, Valentina, Grosso, Nicolas, and Marin, Frédéric
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
[Abridged] ESO 141-G55 is a nearby X-ray bright BLS1, which has been classified as a bare AGN due to the lack of warm absorption along its line-of-sight, providing an unhampered view into its disc-corona system. We aim to probe its disc-corona system thanks to the first simultaneous XMM-Newton and NuSTAR observation obtained on October 1-2, 2022. We carry out the X-ray broadband spectral analysis to determine the dominant process(es) at work, as well as the SED analysis to determine the disc-corona properties. The simultaneous broadband X-ray spectrum of ESO 141-G55 is characterised by the presence of a prominent smooth soft X-ray excess, a broad Fe K emission line and a significant Compton hump. The RGS spectra confirmed the lack of intrinsic warm-absorbing gas along our line of sight in the AGN rest frame, confirming that it is still in a bare state. However, soft X-ray emission lines are observed indicating substantial warm gas out of our line of sight. The intermediate inclination of the disc-corona system, ~43{\deg}, may offer us a favourable configuration to observe UFOs from the disc, but none is found in this 2022 observation, contrary to a previous 2007 XMM-Newton one. Relativistic reflection alone on a standard disc is ruled out from the X-ray broadband analysis, while a combination of soft and hard Comptonisation by a warm and hot corona (relagn), plus relativistic reflection (reflkerrd) reproduces its SED quite well. The hot corona temperature is very hot, ~140 keV, much higher than about 80% of the AGNs, whereas the warm corona temperature, ~0.3 keV, is similar to the values found in other sub-Eddington AGNs. ESO 141-G55 is accreting at a moderate Eddington accretion rate (~10--20%). Our analysis points to a significant contribution of an optically-thick warm corona to both the soft X-ray and UV emission in ESO 141-G55., Comment: 16 pages, 14 figures, 3 appendices; accepted for publication in Astronomy & Astrophysics
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- 2024
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34. ORES-Inspect: A technology probe for machine learning audits on enwiki
- Author
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Levonian, Zachary, Hagen, Lauren, Li, Lu, Lilleboe, Jada, Wastvedt, Solvejg, Halfaker, Aaron, and Terveen, Loren
- Subjects
Computer Science - Human-Computer Interaction ,K.4.2 - Abstract
Auditing the machine learning (ML) models used on Wikipedia is important for ensuring that vandalism-detection processes remain fair and effective. However, conducting audits is challenging because stakeholders have diverse priorities and assembling evidence for a model's [in]efficacy is technically complex. We designed an interface to enable editors to learn about and audit the performance of the ORES edit quality model. ORES-Inspect is an open-source web tool and a provocative technology probe for researching how editors think about auditing the many ML models used on Wikipedia. We describe the design of ORES-Inspect and our plans for further research with this system., Comment: Wiki Workshop 2024
- Published
- 2024
35. Systematic Collapse of the Accretion Disc Across the Supermassive Black Hole Population
- Author
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Hagen, Scott, Done, Chris, Silverman, John D., Li, Junyao, Liu, Teng, Ren, Wenke, Buchner, Johannes, Merloni, Andrea, Nagao, Tohru, and Salvato, Mara
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
The structure of the accretion flow onto supermassive black holes (SMBH) is not well understood. Standard disc models match to zeroth order in predicting substantial energy dissipation within optically-thick material producing a characteristic strong blue/UV continuum. However they fail at reproducing more detailed comparisons to the observed spectral shapes along with their observed variability. Based on stellar mass black holes within our galaxy, accretion discs should undergo a transition into an X-ray hot, radiatively inefficient flow, below a (mass scaled) luminosity of $\sim 0.02\,L_{\rm{Edd}}$. While this has been seen in limited samples of nearby low-luminosity active galactic nuclei (AGN) and a few rare changing-look AGN, it is not at all clear whether this transition is present in the wider AGN population across cosmic time. A key issue is the difficulty in disentangling a change in spectral state from increased dust obscuration and/or host galaxy contamination, effectively drowning out the AGN emission. Here we use the new eROSITA eFEDS Survey to identify unobscured AGN from their X-ray emission, matched to excellent optical imaging from Subaru's Hyper Suprime-Cam; allowing the subtraction of the host galaxy contamination. The resulting, uncontaminated, AGN spectra reveal a smooth transition from a strongly disc dominated state in bright AGN, to the collapse of the disc into an inefficient X-ray plasma in the low luminosity AGN, with the transition occurring at $\sim 0.02\,L_{\rm{Edd}}$; revealing fundamental aspects of accretion physics in AGN., Comment: 11 pages, 5 figure, 3 appendices - Accepted for publication in MNRAS
- Published
- 2024
36. Enhancing Adherence to Recommended Food Practices in Norwegian Kindergartens: The Role of Knowledge and Application of National Guidelines for Food and Meals
- Author
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Kristin E. Fjaera, Ratib Lekhal, Sølvi Helseth, Milada Småstuen Hagen, and Samira Lekhal
- Abstract
Aim: This study sought to investigate the relationship between knowledge and the practical application (including grocery lists, meal plans and food-related pedagogical plans) of Norwegian national guidelines for food and meals in kindergartens, together with the quality of food served in adherence to these guidelines. The study also examined the frequency of daily meals provided and the quality of food served. Moreover, it explored whether pedagogical staff's knowledge of these guidelines was linked to their practical application. Method: Data were collected from 324 kindergarten staff members by means of a web-based questionnaire distributed to both public and private kindergartens in Norway between 2018 and 2020. Univariate and multivariate linear regression analyses were employed to explore associations between pedagogical staff knowledge of the content of national guidelines and food quality in line with national guidelines. Results: Of the 324 participating kindergartens, two-thirds were private providers and one-third were public. A total of 155 kindergartens were in eastern Norway, 41 in mid-Norway, 50 in the west, 48 in the south and 26 in northern Norway. The study found that pedagogical staff's knowledge and the use of national guidelines were positively associated with better food quality and adherence to guidelines for food and meals in kindergartens. In addition, the frequency of daily meals provided by kindergartens was associated with food quality. Conclusions: An association was found between pedagogical staff's knowledge and application of national guidelines for food and meals, and the quality of food served in adherence to these guidelines. In addition, a correlation was observed between the frequency of meals provided by a kindergarten and food quality. These findings suggest that stressing the development of a better understanding of the content of national guidelines for food and meals could potentially enhance food and meal practices in kindergartens, but further research to explore this possibility is warranted.
- Published
- 2024
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37. Pneumonia in severely injured patients with thoracic trauma: results of a retrospective observational multi-centre study
- Author
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Sebastian Wutzler, Felix M. Bläsius, Philipp Störmann, Thomas Lustenberger, Michael Frink, Marc Maegele, Matthias Weuster, Jörg Bayer, Michael Caspers, Andreas Seekamp, Ingo Marzi, Hagen Andruszkow, and Frank Hildebrand
- Subjects
Pneumonia ,Thoracic trauma ,ISS ,AIS ,ICU ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background While the incidence and aspects of pneumonia in ICU patients has been extensively discussed in the literature, studies on the occurrence of pneumonia in severely injured patients are rare. The aim of the present study is to elucidate factors associated with the occurrence of pneumonia in severely injured patients with thoracic trauma. Setting Level-I University Trauma Centres associated with the TraumaRegister DGU®. Methods A total of 1162 severely injured adult patients with thoracic trauma documented in the TraumaRegister DGU® (TR-DGU) were included in this study. Demographic data, injury severity, duration of mechanical ventilation (MV), duration of ICU stay, occurrence of pneumonia, bronchoalveolar lavage, aspiration, pathogen details, and incidences of mortality were evaluated. Statistical evaluation was performed using SPSS (Version 25.0, SPSS, Inc.) software. Results The overall incidence of pneumonia was 27.5%. Compared to patients without pneumonia, patients with pneumonia had sustained more severe injuries (mean ISS: 32.6 vs. 25.4), were older (mean age: 51.3 vs. 47.5) and spent longer periods under MV (mean: 368.9 h vs. 114.9 h). Age, sex (male), aspiration, and duration of MV were all independent predictors for pneumonia occurrence in a multivariate analysis. The cut-off point for duration of MV that best discriminated between patients who would and would not develop pneumonia during their hospital stay was 102 h. The extent of thoracic trauma (AISthorax), ISS, and presence of pulmonary comorbidities did not show significant associations to pneumonia incidence in our multivariate analysis. No significant difference in mortality between patients with and without pneumonia was observed. Conclusions Likelihood of pneumonia increases with age, aspiration, and duration of MV. These parameters were not found to be associated with differences in outcomes between patients with and without pneumonia. Future studies should focus on independent parameters to more clearly identify severely injured subgroups with a high risk of developing pneumonia. Level of evidence Level II - Retrospective medical record review.
- Published
- 2019
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38. Correction to: A new multiple trauma model of the mouse
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Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp, and Claudia Neunaber
- Subjects
Diseases of the musculoskeletal system ,RC925-935 - Abstract
After publication of the original article [1], it was noticed that the following corrections needed to be implemented.
- Published
- 2019
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39. Early biological markers of post-acute sequelae of SARS-CoV-2 infection.
- Author
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Lu, Scott, Peluso, Michael, Glidden, David, Davidson, Michelle, Lugtu, Kara, Pineda-Ramirez, Jesus, Tassetto, Michel, Garcia-Knight, Miguel, Zhang, Amethyst, Goldberg, Sarah, Chen, Jessica, Fortes-Cobby, Maya, Park, Sara, Martinez, Ana, So, Matthew, Donovan, Aidan, Viswanathan, Badri, Hoh, Rebecca, Donohue, Kevin, McIlwain, David, Gaudiliere, Brice, Anglin, Khamal, Yee, Brandon, Chenna, Ahmed, Winslow, John, Petropoulos, Christos, Deeks, Steven, Briggs-Hagen, Melissa, Andino, Raul, Midgley, Claire, Martin, Jeffrey, Saydah, Sharon, and Kelly, John
- Subjects
Humans ,COVID-19 ,SARS-CoV-2 ,Male ,Female ,Adult ,Viral Load ,Biomarkers ,RNA ,Viral ,Middle Aged ,Post-Acute COVID-19 Syndrome ,Aged ,Cytokines ,Antibodies ,Viral ,Immunoglobulin G - Abstract
To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset. Defining PASC as the presence of any COVID-associated symptom at their 4-month visit, we compared viral markers (quantity and duration of nasal viral RNA load, infectious viral load, and plasma N-antigen level) and host immune markers (IL-6, IL-10, TNF-α, IFN-α, IFN-γ, MCP, IP-10, and Spike IgG) over the acute period. Compared to those who fully recovered, those reporting PASC demonstrated significantly higher maximum levels of SARS-CoV-2 RNA and N-antigen, burden of RNA and infectious viral shedding, and lower Spike-specific IgG levels within 9 days post-illness onset. No significant differences were identified among a panel of host immune markers. Our results suggest early viral dynamics and the associated host immune responses play a role in the pathogenesis of PASC, highlighting the importance of understanding early biological markers in the natural history of PASC.
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- 2024
40. Robotic technology in surgery; a classification system of soft tissue surgical robotic devices.
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Cowan, Brandon, Gomes, Camilla, Morris, Paul, Fryrear, Raymond, Petraiuolo, William, Walton, Matt, Alseidi, Adnan, Horgan, Santiago, and Hagen, Monika
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Classification ,Medical device ,Medical technology ,Robotic surgery ,Robotic-assisted surgery ,Robotic Surgical Procedures ,Humans ,Laparoscopy ,Thoracoscopy ,Equipment Design ,Endoscopy - Abstract
BACKGROUND: The field of robotic-assisted surgery is rapidly growing as many robotic surgical devices are in development and about to enter the market. Currently, there is no universally accepted language for labeling the different robotic systems. To facilitate this communication, we created what is, to our knowledge, the first classification of surgical robotic technologies that organizes and classifies surgical robots used for endoscopy, laparoscopy and thoracoscopy. METHODS: We compiled a list of surgical robots intended to be used for endoscopy, laparoscopy, and/or thoracoscopy by searching United States, European, Hong Kong, Japan, and Korean databases for approved devices. Devices showcased at the 2023 Annual Meeting for the Society of Robotic Surgery were added. We also systematically reviewed the literature for any existing surgical robotic classifications or categorizations. We then created a multidisciplinary committee of 8 surgeons and 2 engineers to construct a proposed classification of the devices included in our search. RESULTS: We identified 40 robotic surgery systems intended to be used for endoscopy, laparoscopy and/or thoracoscopy. The proposed classification organizes robotic devices with regard to architecture, port design, and configuration (modular carts, multi-arm integrated cart, table-attachable or arm-table integration). CONCLUSION: This 3-level classification of robotic surgical devices used for endoscopy, laparoscopy and/or thoracoscopy describes important characteristics of robotic devices systematically.
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- 2024
41. Harnessing the power of new genetic tools to illuminate Giardia biology and pathogenesis
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Hagen, Kari D, Hart, Christopher JS, McInally, Shane G, and Dawson, Scott C
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Biochemistry and Cell Biology ,Genetics ,Biological Sciences ,Digestive Diseases ,Biotechnology ,Emerging Infectious Diseases ,Infectious Diseases ,Biodefense ,2.1 Biological and endogenous factors ,Giardia ,Giardiasis ,Protozoan Proteins ,Humans ,CRISPR-Cas Systems ,Animals ,CRISPR/Cas9 ,morpholino ,CRISPRi ,Cre-Lox ,Developmental Biology ,Biochemistry and cell biology - Abstract
Giardia is a prevalent single-celled microaerophilic intestinal parasite causing diarrheal disease and significantly impacting global health. Double diploid (essentially tetraploid) Giardia trophozoites have presented a formidable challenge to the development of molecular genetic tools to interrogate gene function. High sequence divergence and the high percentage of hypothetical proteins lacking homology to proteins in other eukaryotes have limited our understanding of Giardia protein function, slowing drug target validation and development. For more than 25 years, Giardia A and B assemblages have been readily amenable to transfection with plasmids or linear DNA templates. Here, we highlight the utility and power of genetic approaches developed to assess protein function in Giardia, with particular emphasis on the more recent clustered regularly interspaced palindromic repeats/Cas9-based methods for knockdowns and knockouts. Robust and reliable molecular genetic approaches are fundamental toward the interrogation of Giardia protein function and evaluation of druggable targets. New genetic approaches tailored for the double diploid Giardia are imperative for understanding Giardia's unique biology and pathogenesis.
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- 2024
42. Dissecting the Shared Genetic Architecture of Common Epilepsies With Cortical Brain Morphology.
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Karadag, Naz, Hagen, Espen, Shadrin, Alexey, van der Meer, Dennis, OConnell, Kevin, Rahman, Zillur, Kutrolli, Gleda, Parker, Nadine, Bahrami, Shahram, Fominykh, Vera, Heuser, Kjell, Taubøll, Erik, Steen, Nils, Djurovic, Srdjan, Dale, Anders, Frei, Oleksandr, Andreassen, Ole, and Smeland, Olav
- Abstract
BACKGROUND AND OBJECTIVES: Epilepsies are associated with differences in cortical thickness (TH) and surface area (SA). However, the mechanisms underlying these relationships remain elusive. We investigated the extent to which these phenotypes share genetic influences. METHODS: We analyzed genome-wide association study data on common epilepsies (n = 69,995) and TH and SA (n = 32,877) using Gaussian mixture modeling MiXeR and conjunctional false discovery rate (conjFDR) analysis to quantify their shared genetic architecture and identify overlapping loci. We biologically interrogated the loci using a variety of resources and validated in independent samples. RESULTS: The epilepsies (2.4 k-2.9 k variants) were more polygenic than both SA (1.8 k variants) and TH (1.3 k variants). Despite absent genome-wide genetic correlations, there was a substantial genetic overlap between SA and genetic generalized epilepsy (GGE) (1.1 k), all epilepsies (1.1 k), and juvenile myoclonic epilepsy (JME) (0.7 k), as well as between TH and GGE (0.8 k), all epilepsies (0.7 k), and JME (0.8 k), estimated with MiXeR. Furthermore, conjFDR analysis identified 15 GGE loci jointly associated with SA and 15 with TH, 3 loci shared between SA and childhood absence epilepsy, and 6 loci overlapping between SA and JME. 23 loci were novel for epilepsies and 11 for cortical morphology. We observed a high degree of sign concordance in the independent samples. DISCUSSION: Our findings show extensive genetic overlap between generalized epilepsies and cortical morphology, indicating a complex genetic relationship with mixed-effect directions. The results suggest that shared genetic influences may contribute to cortical abnormalities in epilepsies.
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- 2024
43. Assessing the Fractional Curve for Proper Management of Adult Degenerative Scoliosis.
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Ransom, Seth, Pennington, Zach, Brown, Nolan, Shahrestani, Shane, Ryvlin, Jessica, Shoustari, Ali, Hagen, John, Mikula, Anthony, Lakomkin, Nikita, Diaz-Aguilar, Luis, Elder, Benjamin, Osorio, Joseph, and Pham, Martin
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Adult degenerative scoliosis ,Adult spinal deformity ,Fractional curve ,Neurosurgery ,Radiography ,Spine surgery - Abstract
Adult degenerative scoliosis (ADS) is a coronal plane deformity often accompanied by sagittal plane malalignment. Surgical correction may involve the major and/or distally-located fractional curves (FCs). Correction of the FC has been increasingly recognized as key to ameliorating radicular pain localized to the FC levels. The present study aims to summarize the literature on the rationale for FC correction in ADS. Three databases were systematically reviewed to identify all primary studies reporting the rationale for correcting the FC in ADS. Articles were included if they were English full-text studies with primary data from ADS ( ≥ 18 years old) patients. Seventy-four articles were identified, of which 12 were included after full-text review. Findings suggest FC correction with long-segment fusion terminating at L5 increases the risk of distal junctional degeneration as compared to constructs instrumenting the sacrum. Additionally, circumferential fusion offers greater FC correction, lower reoperation risk, and shorter construct length. Minimally invasive surgery (MIS) techniques may offer effective radiographic correction and improve leg pain associated with foraminal stenosis on the FC concavity, though experiences are limited. Open surgery may be necessary to achieve adequate correction of severe, highly rigid deformities. Current data support major curve correction in ASD where the FC concavity and truncal shift are concordant, suggesting that the FC contributes to the patients overall deformity. Circumferential fusion and the use of kickstand rods can improve correction and enhance the stability and durability of long constructs. Last, MIS techniques show promise for milder deformities but require further investigation.
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- 2024
44. Knowledge Graph Reasoning with Self-supervised Reinforcement Learning
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Ma, Ying, Burns, Owen, Wang, Mingqiu, Li, Gang, Du, Nan, Shafey, Laurent El, Wang, Liqiang, Shafran, Izhak, and Soltau, Hagen
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Reinforcement learning (RL) is an effective method of finding reasoning pathways in incomplete knowledge graphs (KGs). To overcome the challenges of a large action space, a self-supervised pre-training method is proposed to warm up the policy network before the RL training stage. To alleviate the distributional mismatch issue in general self-supervised RL (SSRL), in our supervised learning (SL) stage, the agent selects actions based on the policy network and learns from generated labels; this self-generation of labels is the intuition behind the name self-supervised. With this training framework, the information density of our SL objective is increased and the agent is prevented from getting stuck with the early rewarded paths. Our self-supervised RL (SSRL) method improves the performance of RL by pairing it with the wide coverage achieved by SL during pretraining, since the breadth of the SL objective makes it infeasible to train an agent with that alone. We show that our SSRL model meets or exceeds current state-of-the-art results on all Hits@k and mean reciprocal rank (MRR) metrics on four large benchmark KG datasets. This SSRL method can be used as a plug-in for any RL architecture for a KGR task. We adopt two RL architectures, i.e., MINERVA and MultiHopKG as our baseline RL models and experimentally show that our SSRL model consistently outperforms both baselines on all of these four KG reasoning tasks. Full code for the paper available at https://github.com/owenonline/Knowledge-Graph-Reasoning-with-Self-supervised-Reinforcement-Learning., Comment: 17 pages, 11 figures
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- 2024
45. A Systematic Investigation of Distilling Large Language Models into Cross-Encoders for Passage Re-ranking
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Schlatt, Ferdinand, Fröbe, Maik, Scells, Harrisen, Zhuang, Shengyao, Koopman, Bevan, Zuccon, Guido, Stein, Benno, Potthast, Martin, and Hagen, Matthias
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Computer Science - Information Retrieval - Abstract
Cross-encoders distilled from large language models (LLMs) are often more effective re-rankers than cross-encoders fine-tuned on manually labeled data. However, the distilled models usually do not reach their teacher LLM's effectiveness. To investigate whether best practices for fine-tuning cross-encoders on manually labeled data (e.g., hard-negative sampling, deep sampling, and listwise loss functions) can help to improve LLM ranker distillation, we construct and release a new distillation dataset: Rank-DistiLLM. In our experiments, cross-encoders trained on Rank-DistiLLM reach the effectiveness of LLMs while being orders of magnitude more efficient. Our code and data is available at https://github.com/webis-de/msmarco-llm-distillation.
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- 2024
46. Electromagnetic observables of open-shell nuclei from coupled-cluster theory
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Bonaiti, Francesca, Bacca, Sonia, Hagen, Gaute, and Jansen, Gustav R.
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Nuclear Theory ,Nuclear Experiment - Abstract
We develop a new method to describe electromagnetic observables of open-shell nuclei with two nucleons outside a closed shell. This approach combines the equation-of-motion coupled-cluster method for such systems and the Lorentz integral transform technique, expanding the applicability of coupled-cluster theory for these properties beyond closed-shell nuclei. To validate this new approach, we compute the non-energy-weighted dipole sum rule and the dipole polarizability of $^{16,24}$O in both the closed-shell and the new equation-of-motion coupled-cluster frameworks, finding agreement within error bars. We then analyze the evolution of the dipole polarizability along the oxygen and calcium isotopic chains. Our predictions agree well with available experimental data and other available theoretical calculations for the closed-shell $^{16,22}$O and the open-shell $^{18}$O. In the calcium isotopes, we observe that our dipole polarizability predictions for open-shell nuclei are lower than those of closed-shell nuclei. Our predictions for $^{24}$O and $^{54,56}$Ca will motivate future experimental studies at the dripline., Comment: 18 pages, 7 figures, matches published version on Physical Review C
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- 2024
- Full Text
- View/download PDF
47. Ab initio computations of strongly deformed nuclei around $^{80}$Zr
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Hu, B. S., Sun, Z. H., Hagen, G., and Papenbrock, T.
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Nuclear Theory ,Nuclear Experiment - Abstract
Nuclei around $N\approx Z\approx 40$ are strongly deformed and exhibit coexistence of shapes. These phenomena have challenged nuclear models. Here we perform ab initio coupled-cluster computations of low-lying collective states and electromagnetic quadrupole transitions of the even-even nuclei $^{72}$Kr, $^{76,78}$Sr, $^{78,80}$Zr and $^{84}$Mo starting from chiral nucleon-nucleon and three-nucleon forces. Our calculations reproduce the coexistence of oblate and prolate shapes in these nuclei, yield rotational bands and strong electromagnetic transitions, but are not accurate for some observables and nuclei. These results highlight the advances and challenges of ab initio computations of heavy deformed nuclei., Comment: 10 pages
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- 2024
- Full Text
- View/download PDF
48. Gaussian Splatting: 3D Reconstruction and Novel View Synthesis, a Review
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Dalal, Anurag, Hagen, Daniel, Robbersmyr, Kjell G., and Knausgård, Kristian Muri
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Graphics ,I.2.10 ,I.3.6 ,I.3.7 ,I.3.8 ,I.4.5 ,I.4.8 ,I.4.10 - Abstract
Image-based 3D reconstruction is a challenging task that involves inferring the 3D shape of an object or scene from a set of input images. Learning-based methods have gained attention for their ability to directly estimate 3D shapes. This review paper focuses on state-of-the-art techniques for 3D reconstruction, including the generation of novel, unseen views. An overview of recent developments in the Gaussian Splatting method is provided, covering input types, model structures, output representations, and training strategies. Unresolved challenges and future directions are also discussed. Given the rapid progress in this domain and the numerous opportunities for enhancing 3D reconstruction methods, a comprehensive examination of algorithms appears essential. Consequently, this study offers a thorough overview of the latest advancements in Gaussian Splatting., Comment: 24 pages
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- 2024
- Full Text
- View/download PDF
49. A scoping review of using Large Language Models (LLMs) to investigate Electronic Health Records (EHRs)
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Li, Lingyao, Zhou, Jiayan, Gao, Zhenxiang, Hua, Wenyue, Fan, Lizhou, Yu, Huizi, Hagen, Loni, Zhang, Yongfeng, Assimes, Themistocles L., Hemphill, Libby, and Ma, Siyuan
- Subjects
Computer Science - Emerging Technologies - Abstract
Electronic Health Records (EHRs) play an important role in the healthcare system. However, their complexity and vast volume pose significant challenges to data interpretation and analysis. Recent advancements in Artificial Intelligence (AI), particularly the development of Large Language Models (LLMs), open up new opportunities for researchers in this domain. Although prior studies have demonstrated their potential in language understanding and processing in the context of EHRs, a comprehensive scoping review is lacking. This study aims to bridge this research gap by conducting a scoping review based on 329 related papers collected from OpenAlex. We first performed a bibliometric analysis to examine paper trends, model applications, and collaboration networks. Next, we manually reviewed and categorized each paper into one of the seven identified topics: named entity recognition, information extraction, text similarity, text summarization, text classification, dialogue system, and diagnosis and prediction. For each topic, we discussed the unique capabilities of LLMs, such as their ability to understand context, capture semantic relations, and generate human-like text. Finally, we highlighted several implications for researchers from the perspectives of data resources, prompt engineering, fine-tuning, performance measures, and ethical concerns. In conclusion, this study provides valuable insights into the potential of LLMs to transform EHR research and discusses their applications and ethical considerations.
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- 2024
50. The Framework of a Design Process Language
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Hagen, Arnulf
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Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
The thesis develops a view of design in a concept formation framework and outlines a language to describe both the object of the design and the process of designing. The unknown object at the outset of the design work may be seen as an unknown concept that the designer is to define. Throughout the process, she develops a description of this object by relating it to known concepts. The search stops when the designer is satisfied that the design specification is complete enough to satisfy the requirements from it once built. It is then a collection of propositions that all contribute towards defining the design object - a collection of sentences describing relationships between the object and known concepts. Also, the design process itself may be described by relating known concepts - by organizing known abilities into particular patterns of activation, or mobilization. In view of the demands posed to a language to use in this concept formation process, the framework of a Design Process Language (DPL) is developed. The basis for the language are linguistic categories that act as classes of relations used to combine concepts, containing relations used for describing process and object within the same general system, with some relations being process specific, others being object specific, and with the bulk being used both for process and object description. Another outcome is the distinction of modal relations, or relations describing futurity, possibility, willingness, hypothetical events, and the like. The design process almost always includes aspects such as these, and it is thus necessary for a language facilitating design process description to support such relationships to be constructed. The DPL is argued to be a foundation whereupon to build a language that can be used for enabling computers to be more useful - act more intelligently - in the design process., Comment: PhD dissertation, 1993, Norwegian Institute of Technology
- Published
- 2024
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