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12 results on '"Hagen, Daniela"'

1. Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael

Published
2024
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2. Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Tausch, Christoph, Däster, Kavitha, Hayoz, Stefanie, Matrai, Zoltan, Fitzal, Florian, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Maggi, Nadia, Saccilotto, Ramon, Heidinger, Martin, Mueller, Andreas, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Ruhstaller, Thomas, Muenst, Simone, Kuemmel, Sherko, Vrieling, Conny, Satler, Rok, Becciolini, Charles, Bucher, Susanne, Kurzeder, Christian, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Montagna, Giacomo, Reitsamer, Roland, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Naydina, Tatiana, Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, and Weber, Walter Paul

Published
2023
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3. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael

Published
2024
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4. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Heidinger, Martin, additional, Hayoz, Stefanie, additional, Matrai, Zoltan, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Andreozzi, Mariacarla, additional, Goldschmidt, Maite, additional, Schulz, Alexandra, additional, Mueller, Andreas, additional, Ackerknecht, Markus, additional, Tampaki, Ekaterini Christina, additional, Bjelic-Radisic, Vesna, additional, Kurzeder, Christian, additional, Sávolt, Ákos, additional, Smanykó, Viktor, additional, Hagen, Daniela, additional, Müller, Dieter J., additional, Gnant, Michael, additional, Loibl, Sibylle, additional, Fitzal, Florian, additional, Markellou, Pagona, additional, Bekes, Inga, additional, Egle, Daniel, additional, Heil, Jörg, additional, and Knauer, Michael, additional

Published
2023
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5. Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Heidinger, Martin, additional, Hayoz, Stefanie, additional, Matrai, Zoltan, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Andreozzi, Mariacarla, additional, Goldschmidt, Maite, additional, Schulz, Alexandra, additional, Mueller, Andreas, additional, Ackerknecht, Markus, additional, Tampaki, Ekaterini Christina, additional, Bjelic-Radisic, Vesna, additional, Kurzeder, Christian, additional, Sávolt, Ákos, additional, Smanykó, Viktor, additional, Hagen, Daniela, additional, Müller, Dieter J., additional, Gnant, Michael, additional, Loibl, Sibylle, additional, Fitzal, Florian, additional, Markellou, Pagona, additional, Bekes, Inga, additional, Egle, Daniel, additional, Heil, Jörg, additional, and Knauer, Michael, additional

Published
2023
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6. Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer

Author

Weber, Walter P., Matrai, Zoltan, Hayoz, Stefanie, Tausch, Christoph, Henke, Guido, Zimmermann, Frank, Montagna, Giacomo, Fitzal, Florian, Gnant, Michael, Ruhstaller, Thomas, Muenst, Simone, Mueller, Andreas, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, Egle, Daniel, Sávolt, Ákos, Heidinger, Martin, Kurzeder, Christian, Zwahlen, Daniel R., Gruber, Günther, Ackerknecht, Markus, Kuemmel, Sherko, Bjelic-Radisic, Vesna, Smanykó, Viktor, Vrieling, Conny, Satler, Rok, Hagen, Daniela, Becciolini, Charles, Bucher, Susanne, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Loibl, Sibylle, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Maggi, Nadia, Schulz, Alexandra, Andreozzi, Mariacarla, Goldschmidt, Maite, Saccilotto, Ramon, and Markellou, Pagona

Abstract

IMPORTANCE: The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)–positive breast cancer (BC) is currently unknown. OBJECTIVE: To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT). DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, cohort study conducted from August 2018 to June 2022. This was a preplanned study within the phase 3 randomized clinical OPBC-03/TAXIS trial. Included were patients with confirmed cN-positive BC from 44 private, public, and academic breast centers in 6 European countries. After NACT, residual nodal disease was mandatory, and a minimum follow-up of 2 months was required. EXPOSURES: All patients underwent tailored axillary surgery (TAS) followed by ALND or axillary radiotherapy (ART) according to TAXIS randomization. TAS removed suspicious palpable and sentinel nodes, whereas imaging-guidance was optional. Systemic therapy recommendations were at the discretion of the local investigators. RESULTS: A total of 500 patients (median [IQR] age, 57 [48-69] years; 487 female [97.4%]) were included in the study. In the upfront surgery setting, 296 of 335 patients (88.4%) had hormone receptor (HR)–positive and Erb-B2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 or HER2/neu)–negative disease: 145 (49.0%) underwent ART, and 151 (51.0%) underwent ALND. The median (IQR) number of removed positive lymph nodes without ALND was 3 (1-4) nodes compared with 4 (2-9) nodes with ALND. There was no association of ALND with the proportion of patients undergoing adjuvant chemotherapy (81 of 145 [55.9%] vs 91 of 151 [60.3%]; adjusted odds ratio [aOR], 0.72; 95% CI, 0.19-2.67) and type of systemic therapy. Of 151 patients with NACT, 74 (51.0%) underwent ART, and 77 (49.0%) underwent ALND. The ratio of removed to positive nodes was a median (IQR) of 4 (3-7) nodes to 2 (1-3) nodes and 15 (12-19) nodes to 2 (1-5) nodes in the ART and ALND groups, respectively. There was no observed association of ALND with the proportion of patients undergoing postneoadjuvant systemic therapy (57 of 74 [77.0%] vs 55 of 77 [71.4%]; aOR, 0.86; 95% CI, 0.43-1.70), type of postneoadjuvant chemotherapy (eg, capecitabine: 10 of 74 [13.5%] vs 10 of 77 [13.0%]; trastuzumab emtansine–DM1: 9 of 74 [12.2%] vs 11 of 77 [14.3%]), or endocrine therapy (eg, aromatase inhibitors: 41 of 74 [55.4%] vs 36 of 77 [46.8%]; tamoxifen: 8 of 74 [10.8%] vs 6 of 77 [7.8%]). CONCLUSION: Results of this cohort study suggest that patients without ALND were significantly understaged. However, ALND did not inform systemic therapy recommendations.

Published
2023
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9. Frequency and distribution pattern of distant metastases in breast cancer patients at the time of primary presentation

Author

Schneider, Christoph, Fehr, Mathias, Steiner, Rolf, Hagen, Daniela, Haller, Urs, Fink, Daniel, Schneider, Christoph, Fehr, Mathias, Steiner, Rolf, Hagen, Daniela, Haller, Urs, and Fink, Daniel

Abstract

Introduction.: For routine staging of patients with primary breast cancer, clinical practice guidelines of many medical societies recommend chest X-ray, liver ultrasound and bone scan. With respect to expanding health care costs and patients' psychological distress it has been supposed, that there might be a group of breast cancer patients, who do not need these imaging studies. Methods.: Four hundred and eighty-eight consecutive patients with primary breast cancer who had primary surgery at our institution and complete work-up for distant metastases including chest X-ray, liver ultrasound, and bone scan were studied. Results.: We found distant metastases at the time of primary diagnosis in 19 patients (3.9%). Bone metastases were found in 2.7%, liver metastases in 1.0%, and pulmonary metastases in 0.4%. However, in breast tumors smaller than 1cm, no metastatic lesions were found, whereas 18.2% of the patients with pT4 tumors had metastases. In 2.4% of screening imaging studies, metastases were ruled out by additional imaging. Conclusion.: Based on our data and a review of the literature, we suggest that chest X-ray, liver ultrasound and bone scan can be omitted in the staging of asymptomatic patients with pT1a or pT1b disease

Published
2018

12. Frequency and distribution pattern of distant metastases in breast cancer patients at the time of primary presentation

Author

Schneider, Christoph, Fehr, Mathias, Steiner, Rolf, Hagen, Daniela, Haller, Urs, Fink, Daniel, Schneider, Christoph, Fehr, Mathias, Steiner, Rolf, Hagen, Daniela, Haller, Urs, and Fink, Daniel

Abstract

Introduction.: For routine staging of patients with primary breast cancer, clinical practice guidelines of many medical societies recommend chest X-ray, liver ultrasound and bone scan. With respect to expanding health care costs and patients' psychological distress it has been supposed, that there might be a group of breast cancer patients, who do not need these imaging studies. Methods.: Four hundred and eighty-eight consecutive patients with primary breast cancer who had primary surgery at our institution and complete work-up for distant metastases including chest X-ray, liver ultrasound, and bone scan were studied. Results.: We found distant metastases at the time of primary diagnosis in 19 patients (3.9%). Bone metastases were found in 2.7%, liver metastases in 1.0%, and pulmonary metastases in 0.4%. However, in breast tumors smaller than 1cm, no metastatic lesions were found, whereas 18.2% of the patients with pT4 tumors had metastases. In 2.4% of screening imaging studies, metastases were ruled out by additional imaging. Conclusion.: Based on our data and a review of the literature, we suggest that chest X-ray, liver ultrasound and bone scan can be omitted in the staging of asymptomatic patients with pT1a or pT1b disease

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