Search

Your search keyword '"Hagedorn, A."' showing total 22,920 results
Start Over Author "Hagedorn, A."
22,920 results on '"Hagedorn, A."'

1. Test of the Equivalence Principle for Superconductors

Author

Ross, M. P., Fleischer, S. M., Paulson, I. A., Lamb, P., Iritani, B. M., Adelberger, E. G., Hagedorn, C. A., Venkateswara, K., Gettings, C., Shaw, E. A., Apple, S. K., and Gundlach, J. H.

Subjects
General Relativity and Quantum Cosmology, Condensed Matter - Superconductivity
Abstract

We searched for violations of the weak equivalence principle using a cryogenic torsion balance with a pendulum comprised of superconducting niobium and copper. We constrain the E\"otv\"os parameter with 95%-confidence to $\eta_{\text{Nb*-Cu}}~\leq~2.0\times10^{-9}$ and $\eta_{\text{CP-ee}}\leq9.2\times10^{-4}$ for superconducting niobium and Cooper pairs, respectively.

Published
2024

2. Charged lepton flavour violation from inverse seesaw with flavour and CP symmetries

Author

Di Meglio, F. P. and Hagedorn, C.

Subjects
High Energy Physics - Phenomenology
Abstract

We study charged lepton flavour violation in a scenario in which light neutrino masses are generated via the inverse seesaw mechanism with 3+3 gauge singlet fermions, Ni and Sj, i,j=1,2,3. Lepton mixing is predicted with the help of the flavour symmetries Delta (3 n^2) and Delta (6 n^2) combined with CP. In the neutral lepton sector, the non-trivial flavour structure is only encoded in the Dirac neutrino Yukawa matrix (the coupling relating left-handed lepton doublets and gauge singlets Ni). Current experimental bounds on the processes mu -> e gamma, mu -> 3 e, mu-e conversion in nuclei and the tau lepton decays tau -> l gamma and tau -> 3 l, l=e, mu, do not constrain the considered parameter space of this scenario. Prospective limits on the decay mu -> 3 e and mu-e conversion in aluminium instead can markedly reduce the available parameter space. We also comment on the effects of the heavy sterile states on light neutrino masses and lepton mixing., Comment: 1+48 pages, 24 figures

Published
2024

3. AtLAST Science Overview Report

Author

Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Orlowski-Scherer, John, Saintonge, Amélie, Smith, Matthew W. L., Thelen, Alexander, Wedemeyer, Sven, Akiyama, Kazunori, Andreon, Stefano, Arzoumanian, Doris, Bakx, Tom J. L. C., Bot, Caroline, Bower, Geoffrey, Brajša, Roman, Chen, Chian-Chou, da Cunha, Elisabete, Eden, David, Ettori, Stefano, Gaches, Brandt, Hatziminaoglou, Evanthia, Luppe, Patricia, Magnelli, Benjamin, Marshall, Jonathan P., Montenegro-Montes, Francisco Miguel, Niemack, Michael, Nixon, Conor, de Pater, Imke, Perrott, Yvette, Raimundo, Sandra I., Redaelli, Elena, Richards, Anita, Rybak, Matus, Šarčević, Nikolina, Semenov, Dmitry, Spezzano, Silvia, Srinivasan, Sundar, Stanke, Thomas, Andreani, Paola, Beltrán, Maria T., Butler, Bryan J., Cantalupo, Sebastiano, Dagostino, Miguel Chavez, Duarte-Cabral, Ana, Emonts, Bjorn, Fletcher, Leigh, Gary, Dale E., Gunar, Stanislav, Hacar, Alvaro, Hagedorn, Bendix, Kaminski, Tomek, Kirton, Fiona, de Kleer, Katherine, Kontar, Eduard, Kuan, Yi-Jehng, Lightfoot, John, Lopez-Rodriguez, Enrique, Lundgren, Andreas, Milam, Stefanie N., Mohan, Atul, Moreno, Raphael, Motorina, Galina G., Moullet, Arielle, Pattle, Kate, Pellizzoni, Alberto, Peretto, Nicolas, Ramasawmy, Joanna, Ricci, Claudio, Rigby, Andrew J., Sánchez-Monge, Álvaro, Saberi, Maryam, Shimojo, Masumi, Simionescu, Aurora, Thompson, Mark, Traficante, Alessio, Vignali, Cristian, and White, Stephen M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

Submillimeter and millimeter wavelengths provide a unique view of the Universe, from the gas and dust that fills and surrounds galaxies to the chromosphere of our own Sun. Current single-dish facilities have presented a tantalising view of the brightest (sub-)mm sources, and interferometers have provided the exquisite resolution necessary to analyse the details in small fields, but there are still many open questions that cannot be answered with current facilities. In this report we summarise the science that is guiding the design of the Atacama Large Aperture Submillimeter Telescope (AtLAST). We demonstrate how tranformational advances in topics including star formation in high redshift galaxies, the diffuse circumgalactic medium, Galactic ecology, cometary compositions and solar flares motivate the need for a 50m, single-dish telescope with a 1-2 degree field of view and a new generation of highly multiplexed continuum and spectral cameras. AtLAST will have the resolution to drastically lower the confusion limit compared to current single-dish facilities, whilst also being able to rapidly map large areas of the sky and detect extended, diffuse structures. Its high sensitivity and large field of view will open up the field of submillimeter transient science by increasing the probability of serendipitous detections. Finally, the science cases listed here motivate the need for a highly flexible operations model capable of short observations of individual targets, large surveys, monitoring programmes, target of opportunity observations and coordinated observations with other observatories. AtLAST aims to be a sustainable, upgradeable, multipurpose facility that will deliver orders of magnitude increases in sensitivity and mapping speeds over current and planned submillimeter observatories., Comment: 47 pages, 12 figures. For further details on AtLAST see https://atlast.uio.no

Published
2024

4. Multidisciplinary management in Fournier's gangrene

Author

Koch, George E, Abbasi, Behzad, Agoubi, Lauren, Breyer, Benjamin N, Clark, Nina, Dick, Brian P, Friedrich, Jeffrey B, Hampson, Lindsay A, Hernandez, Alexandra, Maine, Rebecca, Osterberg, E Charles, Teal, Lindsey, Woodle, Capt Tarah, and Hagedorn, Judith C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Humans, Fournier Gangrene, Male, Debridement, Patient Care Team, Combined Modality Therapy, Anti-Bacterial Agents, Surgery, Clinical sciences
Published
2024

8. Pioneering SE(2)-Equivariant Trajectory Planning for Automated Driving

Author

Hagedorn, Steffen, Milich, Marcel, and Condurache, Alexandru P.

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence, Computer Science - Multiagent Systems
Abstract

Planning the trajectory of the controlled ego vehicle is a key challenge in automated driving. As for human drivers, predicting the motions of surrounding vehicles is important to plan the own actions. Recent motion prediction methods utilize equivariant neural networks to exploit geometric symmetries in the scene. However, no existing method combines motion prediction and trajectory planning in a joint step while guaranteeing equivariance under roto-translations of the input space. We address this gap by proposing a lightweight equivariant planning model that generates multi-modal joint predictions for all vehicles and selects one mode as the ego plan. The equivariant network design improves sample efficiency, guarantees output stability, and reduces model parameters. We further propose equivariant route attraction to guide the ego vehicle along a high-level route provided by an off-the-shelf GPS navigation system. This module creates a momentum from embedded vehicle positions toward the route in latent space while keeping the equivariance property. Route attraction enables goal-oriented behavior without forcing the vehicle to stick to the exact route. We conduct experiments on the challenging nuScenes dataset to investigate the capability of our planner. The results show that the planned trajectory is stable under roto-translations of the input scene which demonstrates the equivariance of our model. Despite using only a small split of the dataset for training, our method improves L2 distance at 3 s by 20.6 % and surpasses the state of the art.

Published
2024

9. Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Gas and dust in nearby galaxies

Author

Liu, Daizhong, Saintonge, Amelie, Bot, Caroline, Kemper, Francisca, Lopez-Rodriguez, Enrique, Smith, Matthew W. L., Stanke, Thomas, Andreani, Paola, Boselli, Alessandro, Cicone, Claudia, Davis, Timothy A., Hagedorn, Bendix, Lasrado, Akhil, Mao, Ann, Viti, Serena, Booth, Mark, Klaassen, Pamela, Mroczkowski, Tony, Bigiel, Frank, Chevance, Melanie, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, Lee, Minju M., Maccarone, Thomas, Thelen, Alexander E., van Kampen, Eelco, and Wedemeyer, Sven

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Understanding the physical processes that regulate star formation and galaxy evolution are major areas of activity in modern astrophysics. Nearby galaxies offer unique opportunities to inspect interstellar medium (ISM), star formation (SF), radiative, dynamic and magnetic physics in great detail from sub-galactic (kpc) scales to sub-cloud (sub-pc) scales, from quiescent galaxies to starbursts, and from field galaxies to overdensities. In this case study, we discuss the major breakthroughs in this area of research that will be enabled by the Atacama Large Aperture Submillimeter Telescope (AtLAST), a proposed 50-m single-dish submillimeter telescope. The new discovery space of AtLAST comes from its exceptional sensitivity, in particular to extended low surface brightness emission, a very large 2 degree field of view, and correspondingly high mapping efficiency. This paper focuses on four themes which will particularly benefit from AtLAST: 1) the LMC and SMC, 2) extragalactic magnetic fields, 3) the physics and chemistry of the interstellar medium, and 4) star formation and galaxy evolution. With ~1000-2000h surveys each, AtLAST could deliver deep dust continuum maps of the entire LMC and SMC fields at parsec-scale resolution, high-resolution maps of the magnetic field structure, gas density, temperature and composition of the dense and diffuse ISM in ~100 nearby galaxies, as well as the first large-scale blind CO survey in the nearby Universe, delivering molecular gas masses for up to 10^6 galaxies (3 orders of magnitude more than current samples). Through such observing campaigns, AtLAST will have a profound impact on our understanding of the baryon cycle and star formation across a wide range of environments., Comment: 29 pages, 11 figues, submitted to Open Research Europe as part of the AtLAST collection: https://open-research-europe.ec.europa.eu/collections/atlast/about

Published
2024

10. Molecular gas scaling relations for local star-forming galaxies in the low-$M_*$ regime

Author

Hagedorn, B., Cicone, C., Sarzi, M., Saintonge, A., Severgnini, P., Vignali, C., Shen, S., Rubinur, K., Schimek, A., and Lasrado, A.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We derived molecular gas fractions ($f_\mathrm{mol}=M_\mathrm{mol}/M_*$) and depletion times ($\tau_\mathrm{mol}= M_\mathrm{mol}/\mathrm{SFR} $) for 353 galaxies representative of the local star-forming population with $10^{8.5}\,M_\odot < M_* < 10^{10.5}\,M_\odot$ drawn from the ALLSMOG and xCOLDGASS surveys of CO(2-1) and CO(1-0) line emission. By adding constraints from low-mass galaxies and upper limits for CO non-detections, we find the median molecular gas fraction of the local star-forming population to be constant at $\log f_\mathrm{mol}=-0.99^{+0.22}_{-0.19}$, challenging previous reports of increased molecular gas fractions in low-mass galaxies. Above $M_*\sim 10^{10.5}\,M_\odot$, we find the $f_\mathrm{mol}$ vs. $M_*$ relation to be sensitive to the selection criteria for star-forming galaxies. We tested the robustness of our results against different prescriptions for the CO-to-H$_2$ conversion factor and different selection criteria for star-forming galaxies. The depletion timescale $\tau_\mathrm{mol}$ weakly depends on $M_*$, following a power law with a best-fit slope of $0.16\pm 0.03$. This suggests that small variations in specific SFR ($ \mathrm{sSFR=SFR}/M_*$) across the local main sequence of star-forming galaxies with $M_* < 10^{10.5}\,M_\odot$ are mainly driven by differences in the efficiency of converting the available molecular gas into stars. We tested these results against a possible dependence of $f_\mathrm{mol}$ and $\tau_\mathrm{mol}$ on the surrounding (group) environment of the targets by splitting them into centrals, satellites, and isolated galaxies, and find no significant variation between these populations. We conclude that the group environment is unlikely to have a large systematic effect on the molecular gas content of star-forming galaxies in the local Universe., Comment: Accepted for publication in A&A. 16 pages, 15 figures

Published
2024
Full Text
View/download PDF

11. A possible relation between global CO excitation and massive molecular outflows in local ULIRGs

Author

Arroyave, I. Montoya, Cicone, C., Andreani, P., Weiss, A., De Breuck, C., Lundgren, A., Severgnini, P., Hagedorn, B., Rubinur, K., Baumschlager, B., and Makroleivaditi, E.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Local ULIRGs host ubiquitous molecular outflows, including the most massive and powerful ever detected. These sources have also exceptionally excited global, galaxy-integrated CO ladders. A connection between outflows and molecular gas excitation has however never been established, since previous multi-J CO surveys were limited in spectral resolution and sensitivity and so could only probe the global molecular gas conditions. We address this question using new, ground-based, sensitive heterodyne spectroscopy of multiple CO rotational lines (up to CO(7-6)) in a sample of 17 local ULIRGs. We used the APEX telescope to survey the CO($J_{up}\geq4$) lines at a high signal-to-noise ratio, and complemented these data with CO($J_{up}\leq3$) observations presented in Montoya Arroyave et al. (2023). We detected 74 (out of 75) CO lines, with up to six transitions per source. Some CO SLEDs peak at $J_{up}\sim3,4$, which we classify as 'lower excitation', while others plateau or keep increasing up to the highest-J CO transition probed, and we classify these as 'higher excitation'. Our analysis includes the results of CO SLED fits performed with a single large velocity gradient component, but our main focus is the investigation of possible links between global CO excitation and the presence of broad and/or high-velocity CO spectral components that can contain outflowing gas. We discovered an increasing trend of line width as a function of $J_{up}$ of the CO transition, which is significant at the $4\sigma$ level and appears to be driven by the eight sources classified as 'higher excitation'. For such ULIRGs we found that the CO ladders are more excited for spectral components characterised by higher velocities and/or velocity dispersion. We favour an interpretation whereby the highly excited CO-emitting gas in ULIRGs resides in galactic-scale massive molecular outflows., Comment: Accepted for publication in A&A. 34 pages, 23 figures. Abstract significantly abridged for arXiv submission

Published
2024
Full Text
View/download PDF

12. The Galois Group of $x^{2p}+bx^p+c^p$ over $\mathbb{Q}$

Author

Jim, Akash and Hagedorn, Thomas

Subjects
Mathematics - Number Theory, 12F10, 12E05, 11R09
Abstract

We prove an irreducibility criterion for polynomials of the form $h(x)=x^{2m} + bx^m + c_1 \in F[x]$ relating to the Dickson polynomials of the first kind $D_p$. In the case when $F = \mathbb{Q}$, $m$ is a prime $p>3$, and $c_1=c^p$, for $c\in\mathbb{Q}$, we explicitly determine the Galois group of $d_h= D_p(x, c) + b$, which is $\mathrm{Aff}(\mathbb{F}_p)$ or $C_p \rtimes C_{(p - 1)/2} \vartriangleleft \mathrm{Aff}(\mathbb{F}_p)$, and the Galois group of $h$, which is $C_2 \times \mathrm{Aff}(\mathbb{F}_p), \mathrm{Aff}(\mathbb{F}_p)$, or $C_2 \times (C_p \rtimes C_{(p - 1)/2}) \vartriangleleft C_2 \times \mathrm{Aff}(\mathbb{F}_p)$., Comment: 15 pages, 3 figures

Published
2024

15. Percutaneous image-guided lumbar decompression and outpatient laminectomy for the treatment of lumbar spinal stenosis: a 2-year Medicare claims benchmark study.

Author

Staats, Peter, Dorsi, Michael, Reece, David, Strand, Natalie, Poree, Lawrence, and Hagedorn, Jonathan

Subjects
Lumbar spinal stenosis, Medicare claims, Neurogenic claudication, Outpatient laminectomy, PILD, Percutaneous image-guided lumbar decompression, mild
Abstract

BACKGROUND: This prospective longitudinal study compares outcomes for Medicare beneficiaries receiving outpatient percutaneous image-guided lumbar decompression (PILD) using the mild® procedure to patients undergoing outpatient laminectomy. All patients were diagnosed with lumbar spinal stenosis (LSS) with neurogenic claudication (NC). METHODS: All medical claims for 100 % of Medicare beneficiaries were reviewed, with study subjects identified using Centers for Medicare and Medicaid Research Identifiable Files. Baseline data were extracted individually to allow for longitudinal analysis through two-year follow-up. The index procedure was defined as the first mild or outpatient laminectomy during the enrollment period. The rate of subsequent surgical procedures and incidence of harms were used as study outcomes. RESULTS: Cohorts included 2197 mild and 7416 laminectomy patients. mild patients were significantly older (76.7 years versus 73.4 years, respectively; p

Published
2024

16. ECAP-controlled closed-loop versus open-loop SCS for the treatment of chronic pain: 36-month results of the EVOKE blinded randomized clinical trial.

Author

Mekhail, Nagy, Levy, Robert, Deer, Timothy, Kapural, Leonardo, Li, Sean, Amirdelfan, Kasra, Pope, Jason, Hunter, Corey, Rosen, Steven, Costandi, Shrif, Falowski, Steven, Burgher, Abram, Gilmore, Christopher, Qureshi, Farooq, Staats, Peter, Scowcroft, James, McJunkin, Tory, Carlson, Jonathan, Kim, Christopher, Yang, Michael, Stauss, Thomas, Petersen, Erika, Hagedorn, Jonathan, Rauck, Richard, Kallewaard, Jan, Baranidharan, Ganesan, Taylor, Rod, Poree, Lawrence, Brounstein, Dan, Duarte, Rui, Gmel, Gerrit, Gorman, Robert, Gould, Ian, Hanson, Erin, Karantonis, Dean, Khurram, Abeer, Leitner, Angela, Mugan, Dave, Obradovic, Milan, Ouyang, Zhonghua, Parker, John, Single, Peter, and Soliday, Nicole

Subjects
CHRONIC PAIN, Neuromodulation, Spinal Cord Stimulation, Humans, Male, Female, Spinal Cord Stimulation, Middle Aged, Chronic Pain, Treatment Outcome, Adult, Aged, Single-Blind Method, Pain Measurement, Time Factors, Action Potentials, Quality of Life
Abstract

INTRODUCTION: The evidence for spinal cord stimulation (SCS) has been criticized for the absence of blinded, parallel randomized controlled trials (RCTs) and limited evaluations of the long-term effects of SCS in RCTs. The aim of this study was to determine whether evoked compound action potential (ECAP)-controlled, closed-loop SCS (CL-SCS) is associated with better outcomes when compared with fixed-output, open-loop SCS (OL-SCS) 36 months following implant. METHODS: The EVOKE study was a multicenter, participant-blinded, investigator-blinded, and outcome assessor-blinded, randomized, controlled, parallel-arm clinical trial that compared ECAP-controlled CL-SCS with fixed-output OL-SCS. Participants with chronic, intractable back and leg pain refractory to conservative therapy were enrolled between January 2017 and February 2018, with follow-up through 36 months. The primary outcome was a reduction of at least 50% in overall back and leg pain. Holistic treatment response, a composite outcome including pain intensity, physical and emotional functioning, sleep, and health-related quality of life, and objective neural activation was also assessed. RESULTS: At 36 months, more CL-SCS than OL-SCS participants reported ≥50% reduction (CL-SCS=77.6%, OL-SCS=49.3%; difference: 28.4%, 95% CI 12.8% to 43.9%, p

Published
2024

17. Management of pediatric renal trauma: Results from the American Association for Surgery and Trauma Multi-Institutional Pediatric Acute Renal Trauma Study

Author

Hwang, Catalina K, Matta, Rano, Woolstenhulme, Jonathan, Britt, Alexandra K, Schaeffer, Anthony J, Zakaluzny, Scott A, Kleber, Kara Teresa, Sheikali, Adam, Flynn-O'Brien, Katherine T, Sandilos, Georgianna, Shimonovich, Shachar, Fox, Nicole, Hess, Alexis B, Zeller, Kristen A, Koberlein, George C, Levy, Brittany E, Draus, John M, Sacks, Marla, Chen, Catherine, Luo-Owen, Xian, Stephens, Jacob Robert, Shah, Mit, Burks, Frank, Moses, Rachel A, Rezaee, Michael E, Vemulakonda, Vijaya M, Halstead, N Valeska, LaCouture, Hunter M, Nabavizadeh, Behnam, Copp, Hillary, Breyer, Benjamin, Schwartz, Ian, Feia, Kendall, Pagliara, Travis, Shi, Jennifer, Neuville, Paul, and Hagedorn, Judith C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Pediatric, Physical Injury - Accidents and Adverse Effects, 7.3 Management and decision making, Injuries and accidents, Humans, Male, Female, Child, Retrospective Studies, United States, Kidney, Injury Severity Score, Trauma Centers, Adolescent, Wounds, Nonpenetrating, Child, Preschool, Infant, Multi-institutional, pediatric trauma, renal trauma, trauma centers, conservative management, Clinical sciences, Nursing
Abstract

BackgroundPediatric renal trauma is rare and lacks sufficient population-specific data to generate evidence-based management guidelines. A nonoperative approach is preferred and has been shown to be safe. However, bleeding risk assessment and management of collecting system injury are not well understood. We introduce the Multi-institutional Pediatric Acute Renal Trauma Study (Mi-PARTS), a retrospective cohort study designed to address these questions. This article describes the demographics and contemporary management of pediatric renal trauma at Level I trauma centers in the United States.MethodsRetrospective data were collected at 13 participating Level I trauma centers on pediatric patients presenting with renal trauma between 2010 and 2019. Data were gathered on demographics, injury characteristics, management, and short-term outcomes. Descriptive statistics were used to report on demographics, acute management, and outcomes.ResultsIn total, 1,216 cases were included in this study. Of all patients, 67.2% were male, and 93.8% had a blunt injury mechanism. In addition, 29.3% had isolated renal injuries, and 65.6% were high-grade (American Association for the Surgery of Trauma Grades III-V) injuries. The mean Injury Severity Score was 20.5. Most patients were managed nonoperatively (86.4%), and 3.9% had an open surgical intervention, including 2.7% having nephrectomy. Angioembolization was performed in 0.9%. Collecting system intervention was performed in 7.9%. Overall mortality was 3.3% and was only observed in patients with multiple injuries. The rate of avoidable transfer was 28.2%.ConclusionThe management and outcomes of pediatric renal trauma lack data to inform evidence-based guidelines. Nonoperative management of bleeding following renal injury is a well-established practice. Intervention for renal trauma is rare. Our findings reinforce differences from the adult population and highlights opportunities for further investigation. With data made available through Mi-PARTS, we aimed to answer pediatric specific questions, including a pediatric-specific bleeding risk nomogram, and better understanding indications for interventions for collecting system injuries.Level of evidencePrognostic and Epidemiological; Level IV.

Published
2024

20. Flavon vacuum alignment beyond SUSY

Author

Hagedorn, Claudia, López-Ibáñez, M. L., Pérez, M. Jay, Rahat, Moinul Hossain, and Vives, Oscar

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

In flavor models the vacuum alignment of flavons is typically achieved via the $F$-terms of certain fields in the supersymmetric limit. We propose a method for preserving such alignments, up to a rescaling of the vacuum expectation values, even after supersymmetry (and the flavor symmetry) are softly broken, facilitating the vacuum alignment in models which are non-supersymmetric at low energies. Examples of models with different flavor groups, namely $A_4$, $T_7$, $S_4$ and $\Delta(27)$, are discussed., Comment: 28 pages + references

Published
2023

21. The harmonic oscillator on the Moyal-Groenewold plane: an approach via Lie groups and twisted Weyl tuples

Author

Arhancet, Cédric, Hagedorn, Lukas, Kriegler, Christoph, and Portal, Pierre

Subjects
Mathematics - Functional Analysis, High Energy Physics - Theory, Mathematical Physics, Mathematics - Group Theory, Mathematics - Operator Algebras
Abstract

This paper investigates the functional calculus of the harmonic oscillator on each Moyal-Groenewold plane, the noncommutative phase space which is a fundamental object in quantum mechanics. Specifically, we show that the harmonic oscillator admits a bounded $\mathrm{H}^\infty(\Sigma_\omega)$ functional calculus for any angle $0 < \omega < \frac{\pi}{2}$ and even a bounded H\"ormander functional calculus on the associated noncommutative $\mathrm{L}^p$-spaces, where $\Sigma_\omega=\{ z \in \mathbb{C}^*: |\arg z| <\omega \}$. To achieve these results, we develop a connection with the theory of 2-step nilpotent Lie groups by introducing a notion of twisted Weyl tuple and connecting it to some semigroups of operators previously investigated by Robinson via group representations. Along the way, we demonstrate that $\mathrm{L}^p$-square-max decompositions lead to new insights between noncommutative ergodic theory and $R$-boundedness, and we prove a twisted transference principle, which is of independent interest. Our approach accommodates the presence of a constant magnetic field and they are indeed new even in the framework of magnetic Weyl calculus on classical $\mathrm{L}^p$-spaces. Our results contribute to the understanding of functional calculi on noncommutative spaces and have implications for the maximal regularity of the most basic evolution equations associated to the harmonic oscillator., Comment: 70 pages, minor modifications

Published
2023

22. AlGaN/AlN heterostructures: an emerging platform for nonlinear integrated photonics

Author

Gündogdu, Sinan, Pazzagli, Sofia, Pregnolato, Tommaso, Kolbe, Tim, Hagedorn, Sylvia, Weyers, Markus, and Schröder, Tim

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

In the rapidly evolving area of integrated photonics, there is a growing need for materials that satisfy the particular requirements of increasingly complex and specialized devices and applications. Present photonic material platforms have made significant progress over the past years; however, each platform still faces specific material and performance challenges. We introduce a novel material for integrated photonics: Aluminum Gallium Nitride (AlGaN) on Aluminum Nitride (AlN) as a platform for developing reconfigurable and nonlinear on-chip optical systems. AlGaN combines compatibility with standard semiconductor fabrication technologies, high electro-optic modulation capabilities, and large nonlinear coefficients while providing a broad and low-loss spectral transmission range, making it a viable material for advanced photonic applications. In this work, we design and grow AlGaN/AlN heterostructures and integrate fundamental photonic building blocks into these chips. In particular, we fabricate edge couplers, low-loss waveguides, directional couplers, and tunable high-quality factor ring resonators to enable nonlinear light-matter interaction and quantum functionality. The comprehensive platform we present in this work paves the way for nonlinear photon-pair generation applications, on-chip nonlinear quantum frequency conversion, and fast electro-optic modulation for switching and routing classical and quantum light fields.

Published
2023

23. $\mathbb{A}^1$-Brouwer degrees in Macaulay2

Author

Borisov, Nikita, Brazelton, Thomas, Espino, Frenly, Hagedorn, Thomas, Han, Zhaobo, Garcia, Jordy Lopez, Louwsma, Joel, Ong, Wern Juin Gabriel, and Tawfeek, Andrew R.

Subjects
Mathematics - Algebraic Geometry, Mathematics - Commutative Algebra, Mathematics - Algebraic Topology, 14F42, 14-04, 68W30, 11E04, 55M25, 14N10
Abstract

We describe the Macaulay2 package "A1BrouwerDegrees" for computing local and global $\mathbb{A}^1$-Brouwer degrees and studying symmetric bilinear forms over the complex numbers, the real numbers, the rational numbers, and finite fields of characteristic not equal to 2., Comment: 12 pages, 1 figure. Comments welcome!

Published
2023

24. Barriers to college student food access: a scoping review examining policies, systems, and the environment.

Author

Landry, Matthew, Hagedorn-Hatfield, Rebecca, and Zigmont, Victoria

Subjects
College food security, College students, Environment, Food insecurity, Policy, Systems, Humans, Students, Universities, Food Supply, Food Insecurity, COVID-19, Food Assistance, Social Stigma
Abstract

College student food insecurity (FI) is a public health concern. Programming and policies to support students have expanded but utilisation is often limited. The aim of this study was to summarise the barriers to accessing college FI programming guided by the social ecological model (SEM) framework. A scoping review of peer-reviewed literature included an electronic search conducted in MEDLINE, ERIC, and PubMed databases, with a secondary search in Google Scholar. Of the 138 articles identified, 18 articles met eligibility criteria and were included. Articles primarily encompassed organisational (17/18) level barriers, followed by individual (15/18), relationship (15/18), community (9/18), and policy (6/18) levels. Individual barriers included seven themes: Knowledge of Process, Awareness, Limited Time or Schedules, Personal Transportation, Internal Stigma, Perception of Need, and Type of Student. Four relationship barriers were identified: External Stigma, Comparing Need, Limited Availability Causes Negative Perceptions, and Staff. Ten barrier themes comprised the organisational level: Application Process, Operational Process, Location, Hours of Operation, Food Quality, Food Quantity, Food Desirability or Variety of Food, Marketing Materials, Awareness of the Program, and COVID-19 Restrictions. Two barrier themes were identified at the community level, Public Transportation and Awareness of SNAP, while one barrier theme, SNAP Eligibility and Process, encompassed the policy level. Higher education stakeholders should seek to overcome these barriers to the use of food programmes as a means to address the issue of college FI. This review offers recommendations to overcome these barriers at each SEM level.

Published
2024

25. A Systematic Guideline by the ASPN Workgroup on the Evidence, Education, and Treatment Algorithm for Painful Diabetic Neuropathy: SWEET.

Author

Abdullah, Newaj, Tieppo Francio, Vinicius, Falowski, Steven, Ibrahim, Yussr, Malinowski, Mark, Budwany, Ryan, Strand, Natalie, Sochacki, Kamil, Shah, Anuj, Dunn, Tyler, Nasseri, Morad, Lee, David, Kapural, Leonardo, Bedder, Marshall, Petersen, Erika, Amirdelfan, Kasra, Schatman, Michael, Grider, Jay, Sayed, Dawood, Deer, Timothy, Hagedorn, Jonathan, Sayed, Asim, DSouza, Ryan, Lam, Christopher, Khatri, Nasir, Hussaini, Zohra, and Pritzlaff, Scott

Subjects
chronic pain, diabetes, diabetic neuropathy, neuropathy, painful diabetic neuropathy, spinal cord stimulation
Abstract

INTRODUCTION: Painful diabetic neuropathy (PDN) is a leading cause of pain and disability globally with a lack of consensus on the appropriate treatment of those suffering from this condition. Recent advancements in both pharmacotherapy and interventional approaches have broadened the treatment options for PDN. There exists a need for a comprehensive guideline for the safe and effective treatment of patients suffering from PDN. OBJECTIVE: The SWEET Guideline was developed to provide clinicians with the most comprehensive guideline for the safe and appropriate treatment of patients suffering from PDN. METHODS: The American Society of Pain and Neuroscience (ASPN) identified an educational need for a comprehensive clinical guideline to provide evidence-based recommendations for PDN. A multidisciplinary group of international experts developed the SWEET guideline. The world literature in English was searched using Medline, EMBASE, Cochrane CENTRAL, BioMed Central, Web of Science, Google Scholar, PubMed, Current Contents Connect, Meeting Abstracts, and Scopus to identify and compile the evidence for diabetic neuropathy pain treatments (per section as listed in the manuscript) for the treatment of pain. Manuscripts from 2000-present were included in the search process. RESULTS: After a comprehensive review and analysis of the available evidence, the ASPN SWEET guideline was able to rate the literature and provide therapy grades for most available treatments for PDN utilizing the United States Preventive Services Task Force criteria. CONCLUSION: The ASPN SWEET Guideline represents the most comprehensive review of the available treatments for PDN and their appropriate and safe utilization.

Published
2024

29. Exemplar Hospital initiation trial to Enhance Treatment Engagement (EXHIT ENTRE): protocol for CTN-0098B a randomized implementation study to support hospitals in caring for patients with opioid use disorder

Author

Bart, Gavin, Korthuis, P. Todd, Donohue, Julie M., Hagedorn, Hildi J., Gustafson, Dave H., Bazzi, Angela R., Enns, Eva, McNeely, Jennifer, Ghitza, Udi E., Magane, Kara M., Baukol, Paulette, Vena, Ashley, Harris, Jacklyn, Voronca, Delia, and Saitz, Richard

Published
2024
Full Text
View/download PDF

30. Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study

Author

Bayas, Antonios, Mansmann, Ulrich, Ön, Begum Irmak, Hoffmann, Verena S., Berthele, Achim, Mühlau, Mark, Kowarik, Markus C., Krumbholz, Markus, Senel, Makbule, Steuerwald, Verena, Naumann, Markus, Hartberger, Julia, Kerschensteiner, Martin, Oswald, Eva, Ruschil, Christoph, Ziemann, Ulf, Tumani, Hayrettin, Vardakas, Ioannis, Albashiti, Fady, Kramer, Frank, Soto-Rey, Iñaki, Spengler, Helmut, Mayer, Gerhard, Kestler, Hans Armin, Kohlbacher, Oliver, Hagedorn, Marlien, Boeker, Martin, Kuhn, Klaus, Buchka, Stefan, Kohlmayer, Florian, Kirschke, Jan S., Behrens, Lars, Zimmermann, Hanna, Bender, Benjamin, Sollmann, Nico, Havla, Joachim, and Hemmer, Bernhard

Published
2024
Full Text
View/download PDF

31. Advancing forest inventorying and monitoring

Author

Ferretti, Marco, Fischer, Christoph, Gessler, Arthur, Graham, Catherine, Meusburger, Katrin, Abegg, Meinrad, Bebi, Peter, Bergamini, Ariel, Brockerhoff, Eckehard G., Brunner, Ivano, Bühler, Christoph, Conedera, Marco, Cothereau, Pierre, D’Odorico, Petra, Düggelin, Christoph, Ginzler, Christian, Grendelmeier, Alex, Haeni, Matthias, Hagedorn, Frank, Hägeli, Martin, Hegetschweiler, Karin Tessa, Holderegger, Rolf, Krumm, Frank, Gugerli, Felix, Queloz, Valentin, Rigling, Andreas, Risch, Anita C., Rohner, Brigitte, Rosset, Christian, Scherrer, Daniel, Schulz, Tobias, Thürig, Esther, Traub, Berthold, von Arx, Georg, Waldner, Peter, Wohlgemuth, Thomas, Zimmermann, Niklaus E., and Shackleton, Ross T.

Published
2024
Full Text
View/download PDF

32. Identifying factors influencing emerging innovations in hospital discharge decision making in response to system stress: a qualitative study

Author

Allison M. Gustavson, Matthew J. Miller, Natassia Boening, Emily M. Hudson, Jennifer P. Wisdom, Robert E. Burke, and Hildi J. Hagedorn

Subjects
COVID-19 pandemic, Learning Health System, Transitions of care, Veterans patient discharge, Decision making, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The purpose of this qualitative study was to identify emergent rehabilitation innovations and clinician perceptions influencing their implementation and outcomes related to hospital discharge decision-making during the Coronavirus 2019 pandemic. Methods Rehabilitation clinicians were recruited from the Veterans Affairs Health Care System and participated in individual semi-structured interviews guided by the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework. Data were analyzed using a rapid qualitative, deductive team-based approach informed by directed content analysis. Results Twenty-three rehabilitation clinicians representing physical (N = 11) and occupational therapy (N = 12) participated in the study. Three primary themes were generated: (1) Innovation: emerging innovations in discharge processes included perceived increases in team collaboration, shifts in caseload prioritization, and alternative options for post-acute care. (2) Recipients: innovations emerged as approaches to communicating discharge recommendations changed (in-person to virtual) and strong patient/family preferences to discharge to the home challenged collaborative goal setting; and (3) Context: the ability of rehabilitation clinicians to innovate and the form of innovations were influenced by the broader hospital system, interdisciplinary team dynamics, and policy fluctuations. Innovations described by participants included (1) use of technological modalities for interdisciplinary collaboration, (2) expansion of telehealth modalities to deliver care in the home, (3) changes in acute care case prioritization, and (4) alternative options for discharge directly to home. Conclusions Our findings reinforce that rehabilitation clinicians developed innovative strategies to quickly adapt to multiple systems-level factors that were changing in the face of the COVID-19 pandemic. Future research is needed to assess the impact of innovations, remediate unintended consequences, and evaluate the implementation of promising innovations to respond to emerging healthcare delivery needs more rapidly.

Published
2024
Full Text
View/download PDF

33. Defining Diagnostic Uncertainty as a Discourse Type: a Transdisciplinary Approach to Analysing Clinical Narratives of Electronic Health Records

Author

Lindsay C. Nickels, Trisha L. Marshall, Ezra Edgerton, Patrick W. Brady, Philip A. Hagedorn, and James J. Lee

Abstract

Diagnostic uncertainty is prevalent throughout medicine and significantly impacts patient care, especially when it goes unrecognized. However, we lack a reliable clinical means of identifying uncertainty. This study evaluates the narrative discourse within clinical notes in the Electronic Health Record as a means of identifying diagnostic uncertainty. Recognizing that discourse producers use language "semi-automatically" (Partington et al. 2013), we hypothesized that clinicians include distinct indications of uncertainty in their written assessments, which could be elucidated by linguistic analysis. Using a cohort of patients prospectively identified as having an uncertain diagnosis (UD), we conducted a detailed corpus-assisted discourse analysis. The analysis revealed a set of linguistic indicators constitutive of diagnostic uncertainty including terms of modality, register-specific terms, and linguistically identifiable clinical behaviours. This dictionary of UD indicators was thoroughly tested, and its performance was compared with a matched-control dataset. Based on the findings, we built a machine learning classification algorithm with the ability to predict UD patient cohorts with 87.0% accuracy, effectively demonstrating the feasibility of using clinical discourse to classify patients and directly impact the clinical environment.

Published
2024
Full Text
View/download PDF

34. Exposure to Neighborhood Violence and Suicidal Thoughts And Behaviors among Adolescents in the USA: Findings from a Population-Based Study

Author

Philip Baiden, Catherine A. LaBrenz, Danielle R. Harrell, Bethany M. Wood, Edinam C. Gobodzo, John F. Baiden, Vera E. Mets, Aaron Hagedorn, and Savarra K. Howry

Abstract

Suicide has been identified as the second leading cause of death among adolescents in the USA. Although neighborhood violence has also been identified as a major public health issue, few studies have examined the association between exposure to neighborhood violence and suicidal behaviors among adolescents using a large nationally representative sample. Guided by the Interpersonal Theory of Suicide, this study examined the cross-sectional association between exposure to neighborhood violence and suicidal behaviors among adolescents. Data for this study came from the 2021 Adolescent Behaviors and Experiences Survey (n = 7663, 52.1% Female). The outcome variables investigated in this study were suicidal ideation and suicide attempts, and the main explanatory variable was exposure to neighborhood violence. Data were analyzed using sequential hierarchical binary logistic regression. Of the 7663 adolescents examined, 20.1% experienced suicidal ideation and 8.9% attempted suicide at least once during the past 12 months. About 21% of the adolescents reported being exposed to neighborhood violence. Controlling for other factors, we found that exposure to neighborhood violence was associated with 1.38 times higher odds of making suicide attempts (AOR = 1.38, p = 0.029, 95% CI 1.04-1.84). The findings of this study could inform clinicians, practitioners, and school counselors on how to identify adolescents who may be particularly at risk of suicide attempts and focus efforts on prevention.

Published
2024
Full Text
View/download PDF

35. The Integration of Prediction and Planning in Deep Learning Automated Driving Systems: A Review

Author

Hagedorn, Steffen, Hallgarten, Marcel, Stoll, Martin, and Condurache, Alexandru

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Computer Science - Multiagent Systems
Abstract

Automated driving has the potential to revolutionize personal, public, and freight mobility. Beside accurately perceiving the environment, automated vehicles must plan a safe, comfortable, and efficient motion trajectory. To promote safety and progress, many works rely on modules that predict the future motion of surrounding traffic. Modular automated driving systems commonly handle prediction and planning as sequential, separate tasks. While this accounts for the influence of surrounding traffic on the ego vehicle, it fails to anticipate the reactions of traffic participants to the ego vehicle's behavior. Recent methods increasingly integrate prediction and planning in a joint or interdependent step to model bidirectional interactions. To date, a comprehensive overview of different integration principles is lacking. We systematically review state-of-the-art deep learning-based planning systems, and focus on how they integrate prediction. Different facets of the integration ranging from system architecture to high-level behavioral aspects are considered and related to each other. Moreover, we discuss the implications, strengths, and limitations of different integration principles. By pointing out research gaps, describing relevant future challenges, and highlighting trends in the research field, we identify promising directions for future research.

Published
2023

36. ARF1-related disorder: phenotypic and molecular spectrum.

Author

de Sainte Agathe, Jean-Madeleine, Pode-Shakked, Ben, Naudion, Sophie, Michaud, Vincent, Arveiler, Benoit, Fergelot, Patricia, Delmas, Jean, Keren, Boris, Poirsier, Céline, Alkuraya, Fowzan, Tabarki, Brahim, Bend, Eric, Davis, Kellie, Bebin, Martina, Thompson, Michelle, Bryant, Emily, Wagner, Matias, Hannibal, Iris, Lenberg, Jerica, Krenn, Martin, Wigby, Kristen, Friedman, Jennifer, Iascone, Maria, Cereda, Anna, Miao, Térence, LeGuern, Eric, Sherr, Elliott, Caluseriu, Oana, Tidwell, Timothy, Bayrak-Toydemir, Pinar, Hagedorn, Caroline, Brugger, Melanie, Vill, Katharina, Morneau-Jacob, Francois-Dominique, Chung, Wendy, Weaver, Kathryn, Owens, Joshua, Husami, Ammar, Chaudhari, Bimal, Stone, Brandon, Burns, Katie, Li, Rachel, de Lange, Iris, Biehler, Margaux, Ginglinger, Emmanuelle, Gérard, Bénédicte, Stottmann, Rolf, Trimouille, Aurélien, and Argilli, Emanuela

Subjects
epilepsy, human genetics, sequence analysis, DNA, Humans, Brain, Genotype, Intellectual Disability, Microcephaly, Periventricular Nodular Heterotopia, Phenotype, Seizures
Abstract

PURPOSE: ARF1 was previously implicated in periventricular nodular heterotopia (PVNH) in only five individuals and systematic clinical characterisation was not available. The aim of this study is to provide a comprehensive description of the phenotypic and genotypic spectrum of ARF1-related neurodevelopmental disorder. METHODS: We collected detailed phenotypes of an international cohort of individuals (n=17) with ARF1 variants assembled through the GeneMatcher platform. Missense variants were structurally modelled, and the impact of several were functionally validated. RESULTS: De novo variants (10 missense, 1 frameshift, 1 splice altering resulting in 9 residues insertion) in ARF1 were identified among 17 unrelated individuals. Detailed phenotypes included intellectual disability (ID), microcephaly, seizures and PVNH. No specific facial characteristics were consistent across all cases, however microretrognathia was common. Various hearing and visual defects were recurrent, and interestingly, some inflammatory features were reported. MRI of the brain frequently showed abnormalities consistent with a neuronal migration disorder. CONCLUSION: We confirm the role of ARF1 in an autosomal dominant syndrome with a phenotypic spectrum including severe ID, microcephaly, seizures and PVNH due to impaired neuronal migration.

Published
2023

44. The James Webb Space Telescope Mission

Author

Gardner, Jonathan P., Mather, John C., Abbott, Randy, Abell, James S., Abernathy, Mark, Abney, Faith E., Abraham, John G., Abraham, Roberto, Abul-Huda, Yasin M., Acton, Scott, Adams, Cynthia K., Adams, Evan, Adler, David S., Adriaensen, Maarten, Aguilar, Jonathan Albert, Ahmed, Mansoor, Ahmed, Nasif S., Ahmed, Tanjira, Albat, Rüdeger, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Mary Marsha, Allen, Shaune S., Altenburg, Martin, Altunc, Serhat, Alvarez, Jose Lorenzo, Álvarez-Márquez, Javier, de Oliveira, Catarina Alves, Ambrose, Leslie L., Anandakrishnan, Satya M., Andersen, Gregory C., Anderson, Harry James, Anderson, Jay, Anderson, Kristen, Anderson, Sara M., Aprea, Julio, Archer, Benita J., Arenberg, Jonathan W., Argyriou, Ioannis, Arribas, Santiago, Artigau, Étienne, Arvai, Amanda Rose, Atcheson, Paul, Atkinson, Charles B., Averbukh, Jesse, Aymergen, Cagatay, Bacinski, John J., Baggett, Wayne E., Bagnasco, Giorgio, Baker, Lynn L., Balzano, Vicki Ann, Banks, Kimberly A., Baran, David A., Barker, Elizabeth A., Barrett, Larry K., Barringer, Bruce O., Barto, Allison, Bast, William, Baudoz, Pierre, Baum, Stefi, Beatty, Thomas G., Beaulieu, Mathilde, Bechtold, Kathryn, Beck, Tracy, Beddard, Megan M., Beichman, Charles, Bellagama, Larry, Bely, Pierre, Berger, Timothy W., Bergeron, Louis E., Darveau-Bernier, Antoine, Bertch, Maria D., Beskow, Charlotte, Betz, Laura E., Biagetti, Carl P., Birkmann, Stephan, Bjorklund, Kurt F., Blackwood, James D., Blazek, Ronald Paul, Blossfeld, Stephen, Bluth, Marcel, Boccaletti, Anthony, Boegner Jr., Martin E., Bohlin, Ralph C., Boia, John Joseph, Böker, Torsten, Bonaventura, N., Bond, Nicholas A., Bosley, Kari Ann, Boucarut, Rene A., Bouchet, Patrice, Bouwman, Jeroen, Bower, Gary, Bowers, Ariel S., Bowers, Charles W., Boyce, Leslye A., Boyer, Christine T., Boyer, Martha L., Boyer, Michael, Boyer, Robert, Bradley, Larry D., Brady, Gregory R., Brandl, Bernhard R., Brannen, Judith L., Breda, David, Bremmer, Harold G., Brennan, David, Bresnahan, Pamela A., Bright, Stacey N., Broiles, Brian J., Bromenschenkel, Asa, Brooks, Brian H., Brooks, Keira J., Brown, Bob, Brown, Bruce, Brown, Thomas M., Bruce, Barry W., Bryson, Jonathan G., Bujanda, Edwin D., Bullock, Blake M., Bunker, A. J., Bureo, Rafael, Burt, Irving J., Bush, James Aaron, Bushouse, Howard A., Bussman, Marie C., Cabaud, Olivier, Cale, Steven, Calhoon, Charles D., Calvani, Humberto, Canipe, Alicia M., Caputo, Francis M., Cara, Mihai, Carey, Larkin, Case, Michael Eli, Cesari, Thaddeus, Cetorelli, Lee D., Chance, Don R., Chandler, Lynn, Chaney, Dave, Chapman, George N., Charlot, S., Chayer, Pierre, Cheezum, Jeffrey I., Chen, Bin, Chen, Christine H., Cherinka, Brian, Chichester, Sarah C., Chilton, Zachary S., Chittiraibalan, Dharini, Clampin, Mark, Clark, Charles R., Clark, Kerry W., Clark, Stephanie M., Claybrooks, Edward E., Cleveland, Keith A., Cohen, Andrew L., Cohen, Lester M., Colón, Knicole D., Coleman, Benee L., Colina, Luis, Comber, Brian J., Comeau, Thomas M., Comer, Thomas, Reis, Alain Conde, Connolly, Dennis C., Conroy, Kyle E., Contos, Adam R., Contreras, James, Cook, Neil J., Cooper, James L., Cooper, Rachel Aviva, Correia, Michael F., Correnti, Matteo, Cossou, Christophe, Costanza, Brian F., Coulais, Alain, Cox, Colin R., Coyle, Ray T., Cracraft, Misty M., Noriega-Crespo, Alberto, Crew, Keith A., Curtis, Gary J., Cusveller, Bianca, Maciel, Cleyciane Da Costa, Dailey, Christopher T., Daugeron, Frédéric, Davidson, Greg S., Davies, James E., Davis, Katherine Anne, Davis, Michael S., Day, Ratna, de Chambure, Daniel, de Jong, Pauline, De Marchi, Guido, Dean, Bruce H., Decker, John E., Delisa, Amy S., Dell, Lawrence C., Dellagatta, Gail, Dembinska, Franciszka, Demosthenes, Sandor, Dencheva, Nadezhda M., Deneu, Philippe, DePriest, William W., Deschenes, Jeremy, Dethienne, Nathalie, Detre, Örs Hunor, Diaz, Rosa Izela, Dicken, Daniel, DiFelice, Audrey S., Dillman, Matthew, Disharoon, Maureen O., van Dishoeck, Ewine F., Dixon, William V., Doggett, Jesse B., Dominguez, Keisha L., Donaldson, Thomas S., Doria-Warner, Cristina M., Santos, Tony Dos, Doty, Heather, Douglas Jr., Robert E., Doyon, René, Dressler, Alan, Driggers, Jennifer, Driggers, Phillip A., Dunn, Jamie L., DuPrie, Kimberly C., Dupuis, Jean, Durning, John, Dutta, Sanghamitra B., Earl, Nicholas M., Eccleston, Paul, Ecobichon, Pascal, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan D., Eisenhower, Michael, Eisenstein, Daniel J., Hamel, Zaky El, Elie, Michelle L., Elliott, James, Elliott, Kyle Wesley, Engesser, Michael, Espinoza, Néstor, Etienne, Odessa, Etxaluze, Mireya, Evans, Leah, Fabreguettes, Luce, Falcolini, Massimo, Falini, Patrick R., Fatig, Curtis, Feeney, Matthew, Feinberg, Lee D., Fels, Raymond, Ferdous, Nazma, Ferguson, Henry C., Ferrarese, Laura, Ferreira, Marie-Héléne, Ferruit, Pierre, Ferry, Malcolm, Filippazzo, Joseph Charles, Firre, Daniel, Fix, Mees, Flagey, Nicolas, Flanagan, Kathryn A., Fleming, Scott W., Florian, Michael, Flynn, James R., Foiadelli, Luca, Fontaine, Mark R., Fontanella, Erin Marie, Forshay, Peter Randolph, Fortner, Elizabeth A., Fox, Ori D., Framarini, Alexandro P., Francisco, John I., Franck, Randy, Franx, Marijn, Franz, David E., Friedman, Scott D., Friend, Katheryn E., Frost, James R., Fu, Henry, Fullerton, Alexander W., Gaillard, Lionel, Galkin, Sergey, Gallagher, Ben, Galyer, Anthony D., Marín, Macarena García, Gardner, Lisa E., Garland, Dennis, Garrett, Bruce Albert, Gasman, Danny, Gáspár, András, Gastaud, René, Gaudreau, Daniel, Gauthier, Peter Timothy, Geers, Vincent, Geithner, Paul H., Gennaro, Mario, Gerber, John, Gereau, John C., Giampaoli, Robert, Giardino, Giovanna, Gibbons, Paul C., Gilbert, Karolina, Gilman, Larry, Girard, Julien H., Giuliano, Mark E., Gkountis, Konstantinos, Glasse, Alistair, Glassmire, Kirk Zachary, Glauser, Adrian Michael, Glazer, Stuart D., Goldberg, Joshua, Golimowski, David A., Gonzaga, Shireen P., Gordon, Karl D., Gordon, Shawn J., Goudfrooij, Paul, Gough, Michael J., Graham, Adrian J., Grau, Christopher M., Green, Joel David, Greene, Gretchen R., Greene, Thomas P., Greenfield, Perry E., Greenhouse, Matthew A., Greve, Thomas R., Greville, Edgar M., Grimaldi, Stefano, Groe, Frank E., Groebner, Andrew, Grumm, David M., Grundy, Timothy, Güdel, Manuel, Guillard, Pierre, Guldalian, John, Gunn, Christopher A., Gurule, Anthony, Gutman, Irvin Meyer, Guy, Paul D., Guyot, Benjamin, Hack, Warren J., Haderlein, Peter, Hagan, James B., Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest Clifford, Hammann, Jeffrey, Hammel, Heidi B., Hanley, Christopher J., Hansen, Carl August, Hardy, Bruce, Harnisch, Bernd, Harr, Michael Hunter, Harris, Pamela, Hart, Jessica Ann, Hartig, George F., Hasan, Hashima, Hashim, Kathleen Marie, Hashimoto, Ryan, Haskins, Sujee J., Hawkins, Robert Edward, Hayden, Brian, Hayden, William L., Healy, Mike, Hecht, Karen, Heeg, Vince J., Hejal, Reem, Helm, Kristopher A., Hengemihle, Nicholas J., Henning, Thomas, Henry, Alaina, Henry, Ronald L., Henshaw, Katherine, Hernandez, Scarlin, Herrington, Donald C., Heske, Astrid, Hesman, Brigette Emily, Hickey, David L., Hilbert, Bryan N., Hines, Dean C., Hinz, Michael R., Hirsch, Michael, Hitcho, Robert S., Hodapp, Klaus, Hodge, Philip E., Hoffman, Melissa, Holfeltz, Sherie T., Holler, Bryan Jason, Hoppa, Jennifer Rose, Horner, Scott, Howard, Joseph M., Howard, Richard J., Huber, Jean M., Hunkeler, Joseph S., Hunter, Alexander, Hunter, David Gavin, Hurd, Spencer W., Hurst, Brendan J., Hutchings, John B., Hylan, Jason E., Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra M., Isaacs III, John C., Jackson Jr., Wallace C., Jaffe, Daniel T., Jahic, Jasmin, Jahromi, Amir, Jakobsen, Peter, James, Bryan, James, John C., James, LeAndrea Rae, Jamieson, William Brian, Jandra, Raymond D., Jayawardhana, Ray, Jedrzejewski, Robert, Jeffers, Basil S., Jensen, Peter, Joanne, Egges, Johns, Alan T., Johnson, Carl A., Johnson, Eric L., Johnson, Patricia, Johnson, Phillip Stephen, Johnson, Thomas K., Johnson, Timothy W., Johnstone, Doug, Jollet, Delphine, Jones, Danny P., Jones, Gregory S., Jones, Olivia C., Jones, Ronald A., Jones, Vicki, Jordan, Ian J., Jordan, Margaret E., Jue, Reginald, Jurkowski, Mark H., Justis, Grant, Justtanont, Kay, Kaleida, Catherine C., Kalirai, Jason S., Kalmanson, Phillip Cabrales, Kaltenegger, Lisa, Kammerer, Jens, Kan, Samuel K., Kanarek, Graham Childs, Kao, Shaw-Hong, Karakla, Diane M., Karl, Hermann, Kassin, Susan A., Kauffman, David D., Kavanagh, Patrick, Kelley, Leigh L., Kelly, Douglas M., Kendrew, Sarah, Kennedy, Herbert V., Kenny, Deborah A., Keski-Kuha, Ritva A., Keyes, Charles D., Khan, Ali, Kidwell, Richard C., Kimble, Randy A., King, James S., King, Richard C., Kinzel, Wayne M., Kirk, Jeffrey R., Kirkpatrick, Marc E., Klaassen, Pamela, Klingemann, Lana, Klintworth, Paul U., Knapp, Bryan Adam, Knight, Scott, Knollenberg, Perry J., Knutsen, Daniel Mark, Koehler, Robert, Koekemoer, Anton M., Kofler, Earl T., Kontson, Vicki L., Kovacs, Aiden Rose, Kozhurina-Platais, Vera, Krause, Oliver, Kriss, Gerard A., Krist, John, Kristoffersen, Monica R., Krogel, Claudia, Krueger, Anthony P., Kulp, Bernard A., Kumari, Nimisha, Kwan, Sandy W., Kyprianou, Mark, Labador, Aurora Gadiano, Labiano, Álvaro, Lafrenière, David, Lagage, Pierre-Olivier, Laidler, Victoria G., Laine, Benoit, Laird, Simon, Lajoie, Charles-Philippe, Lallo, Matthew D., Lam, May Yen, LaMassa, Stephanie Marie, Lambros, Scott D., Lampenfield, Richard Joseph, Lander, Matthew Ed, Langston, James Hutton, Larson, Kirsten, Larson, Melora, LaVerghetta, Robert Joseph, Law, David R., Lawrence, Jon F., Lee, David W., Lee, Janice, Lee, Yat-Ning Paul, Leisenring, Jarron, Leveille, Michael Dunlap, Levenson, Nancy A., Levi, Joshua S., Levine, Marie B., Lewis, Dan, Lewis, Jake, Lewis, Nikole, Libralato, Mattia, Lidon, Norbert, Liebrecht, Paula Louisa, Lightsey, Paul, Lilly, Simon, Lim, Frederick C., Lim, Pey Lian, Ling, Sai-Kwong, Link, Lisa J., Link, Miranda Nicole, Lipinski, Jamie L., Liu, XiaoLi, Lo, Amy S., Lobmeyer, Lynette, Logue, Ryan M., Long, Chris A., Long, Douglas R., Long, Ilana D., Long, Knox S., López-Caniego, Marcos, Lotz, Jennifer M., Love-Pruitt, Jennifer M., Lubskiy, Michael, Luers, Edward B., Luetgens, Robert A., Luevano, Annetta J., Lui, Sarah Marie G. Flores, Lund III, James M., Lundquist, Ray A., Lunine, Jonathan, Lützgendorf, Nora, Lynch, Richard J., MacDonald, Alex J., MacDonald, Kenneth, Macias, Matthew J., Macklis, Keith I., Maghami, Peiman, Maharaja, Rishabh Y., Maiolino, Roberto, Makrygiannis, Konstantinos G., Malla, Sunita Giri, Malumuth, Eliot M., Manjavacas, Elena, Marini, Andrea, Marrione, Amanda, Marston, Anthony, Martel, André R, Martin, Didier, Martin, Peter G., Martinez, Kristin L., Maschmann, Marc, Masci, Gregory L., Masetti, Margaret E., Maszkiewicz, Michael, Matthews, Gary, Matuskey, Jacob E., McBrayer, Glen A., McCarthy, Donald W., McCaughrean, Mark J., McClare, Leslie A., McClare, Michael D., McCloskey, John C., McClurg, Taylore D., McCoy, Martin, McElwain, Michael W., McGregor, Roy D., McGuffey, Douglas B., McKay, Andrew G., McKenzie, William K., McLean, Brian, McMaster, Matthew, McNeil, Warren, De Meester, Wim, Mehalick, Kimberly L., Meixner, Margaret, Meléndez, Marcio, Menzel, Michael P., Menzel, Michael T., Merz, Matthew, Mesterharm, David D., Meyer, Michael R., Meyett, Michele L., Meza, Luis E., Midwinter, Calvin, Milam, Stefanie N., Miller, Jay Todd, Miller, William C., Miskey, Cherie L., Misselt, Karl, Mitchell, Eileen P., Mohan, Martin, Montoya, Emily E., Moran, Michael J., Morishita, Takahiro, Moro-Martín, Amaya, Morrison, Debra L., Morrison, Jane, Morse, Ernie C., Moschos, Michael, Moseley, S. H., Mosier, Gary E., Mosner, Peter, Mountain, Matt, Muckenthaler, Jason S., Mueller, Donald G., Mueller, Migo, Muhiem, Daniella, Mühlmann, Prisca, Mullally, Susan Elizabeth, Mullen, Stephanie M., Munger, Alan J, Murphy, Jess, Murray, Katherine T., Muzerolle, James C., Mycroft, Matthew, Myers, Andrew, Myers, Carey R., Myers, Fred Richard R., Myers, Richard, Myrick, Kaila, Nagle IV, Adrian F., Nayak, Omnarayani, Naylor, Bret, Neff, Susan G., Nelan, Edmund P., Nella, John, Nguyen, Duy Tuong, Nguyen, Michael N., Nickson, Bryony, Nidhiry, John Joseph, Niedner, Malcolm B., Nieto-Santisteban, Maria, Nikolov, Nikolay K., Nishisaka, Mary Ann, Nota, Antonella, O'Mara, Robyn C., Oboryshko, Michael, O'Brien, Marcus B., Ochs, William R., Offenberg, Joel D., Ogle, Patrick Michael, Ohl, Raymond G., Olmsted, Joseph Hamden, Osborne, Shannon Barbara, O'Shaughnessy, Brian Patrick, Östlin, Göran, O'Sullivan, Brian, Otor, O. Justin, Ottens, Richard, Ouellette, Nathalie N. -Q., Outlaw, Daria J., Owens, Beverly A., Pacifici, Camilla, Page, James Christophe, Paranilam, James G., Park, Sang, Parrish, Keith A., Paschal, Laura, Patapis, Polychronis, Patel, Jignasha, Patrick, Keith, Pattishall Jr., Robert A., Paul, Douglas William, Paul, Shirley J., Pauly, Tyler Andrew, Pavlovsky, Cheryl M., Peña-Guerrero, Maria, Pedder, Andrew H., Peek, Matthew Weldon, Pelham, Patricia A., Penanen, Konstantin, Perriello, Beth A., Perrin, Marshall D., Perrine, Richard F., Perrygo, Chuck, Peslier, Muriel, Petach, Michael, Peterson, Karla A., Pfarr, Tom, Pierson, James M., Pietraszkiewicz, Martin, Pilchen, Guy, Pipher, Judy L., Pirzkal, Norbert, Pitman, Joseph T., Player, Danielle M., Plesha, Rachel, Plitzke, Anja, Pohner, John A., Poletis, Karyn Konstantin, Pollizzi, Joseph A., Polster, Ethan, Pontius, James T., Pontoppidan, Klaus, Porges, Susana C., Potter, Gregg D., Prescott, Stephen, Proffitt, Charles R., Pueyo, Laurent, Neira, Irma Aracely Quispe, Radich, Armando, Rager, Reiko T., Rameau, Julien, Ramey, Deborah D., Alarcon, Rafael Ramos, Rampini, Riccardo, Rapp, Robert, Rashford, Robert A., Rauscher, Bernard J., Ravindranath, Swara, Rawle, Timothy, Rawlings, Tynika N., Ray, Tom, Regan, Michael W., Rehm, Brian, Rehm, Kenneth D., Reid, Neill, Reis, Carl A., Renk, Florian, Reoch, Tom B., Ressler, Michael, Rest, Armin W., Reynolds, Paul J., Richon, Joel G., Richon, Karen V., Ridgaway, Michael, Riedel, Adric Richard, Rieke, George H., Rieke, Marcia, Rifelli, Richard E., Rigby, Jane R., Riggs, Catherine S., Ringel, Nancy J., Ritchie, Christine E., Rix, Hans-Walter, Robberto, Massimo, Robinson, Michael S., Robinson, Orion, Rock, Frank W., Rodriguez, David R., del Pino, Bruno Rodríguez, Roellig, Thomas, Rohrbach, Scott O., Roman, Anthony J., Romelfanger, Frederick J., Romo Jr., Felipe P., Rosales, Jose J., Rose, Perry, Roteliuk, Anthony F., Roth, Marc N., Rothwell, Braden Quinn, Rouzaud, Sylvain, Rowe, Jason, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Rui, Chunlei, Rumler, Peter, Rumpl, William, Russ, Melissa L., Ryan, Michael B., Ryan, Richard M., Saad, Karl, Sabata, Modhumita, Sabatino, Rick, Sabbi, Elena, Sabelhaus, Phillip A., Sabia, Stephen, Sahu, Kailash C., Saif, Babak N., Salvignol, Jean-Christophe, Samara-Ratna, Piyal, Samuelson, Bridget S., Sanders, Felicia A., Sappington, Bradley, Sargent, B. A., Sauer, Arne, Savadkin, Bruce J., Sawicki, Marcin, Schappell, Tina M., Scheffer, Caroline, Scheithauer, Silvia, Scherer, Ron, Schiff, Conrad, Schlawin, Everett, Schmeitzky, Olivier, Schmitz, Tyler S., Schmude, Donald J., Schneider, Analyn, Schreiber, Jürgen, Schroeven-Deceuninck, Hilde, Schultz, John J., Schwab, Ryan, Schwartz, Curtis H., Scoccimarro, Dario, Scott, John F., Scott, Michelle B., Seaton, Bonita L., Seely, Bruce S., Seery, Bernard, Seidleck, Mark, Sembach, Kenneth, Shanahan, Clare Elizabeth, Shaughnessy, Bryan, Shaw, Richard A., Shay, Christopher Michael, Sheehan, Even, Sheth, Kartik, Shih, Hsin-Yi, Shivaei, Irene, Siegel, Noah, Sienkiewicz, Matthew G., Simmons, Debra D., Simon, Bernard P., Sirianni, Marco, Sivaramakrishnan, Anand, Slade, Jeffrey E., Sloan, G. C., Slocum, Christine E., Slowinski, Steven E., Smith, Corbett T., Smith, Eric P., Smith, Erin C., Smith, Koby, Smith, Robert, Smith, Stephanie J., Smolik, John L., Soderblom, David R., Sohn, Sangmo Tony, Sokol, Jeff, Sonneborn, George, Sontag, Christopher D., Sooy, Peter R., Soummer, Remi, Southwood, Dana M., Spain, Kay, Sparmo, Joseph, Speer, David T., Spencer, Richard, Sprofera, Joseph D., Stallcup, Scott S., Stanley, Marcia K., Stansberry, John A., Stark, Christopher C., Starr, Carl W., Stassi, Diane Y., Steck, Jane A., Steeley, Christine D., Stephens, Matthew A., Stephenson, Ralph J., Stewart, Alphonso C., Stiavelli, Massimo, Stockman Jr., Hervey, Strada, Paolo, Straughn, Amber N., Streetman, Scott, Strickland, David Kendal, Strobele, Jingping F., Stuhlinger, Martin, Stys, Jeffrey Edward, Such, Miguel, Sukhatme, Kalyani, Sullivan, Joseph F., Sullivan, Pamela C., Sumner, Sandra M., Sun, Fengwu, Sunnquist, Benjamin Dale, Swade, Daryl Allen, Swam, Michael S., Swenton, Diane F., Swoish, Robby A., Litten, Oi In Tam, Tamas, Laszlo, Tao, Andrew, Taylor, David K., Taylor, Joanna M., Plate, Maurice te, Van Tea, Mason, Teague, Kelly K., Telfer, Randal C., Temim, Tea, Texter, Scott C., Thatte, Deepashri G., Thompson, Christopher Lee, Thompson, Linda M., Thomson, Shaun R., Thronson, Harley, Tierney, C. M., Tikkanen, Tuomo, Tinnin, Lee, Tippet, William Thomas, Todd, Connor William, Tran, Hien D., Trauger, John, Trejo, Edwin Gregorio, Truong, Justin Hoang Vinh, Tsukamoto, Christine L., Tufail, Yasir, Tumlinson, Jason, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael A., Vaclavik, Steven, Valenduc, Frida, Valenti, Jeff A., Van Campen, Julie, van de Wetering, Inge, Van Der Marel, Roeland P., van Haarlem, Remy, Vandenbussche, Bart, Vanterpool, Dona D., Vernoy, Michael R., Costas, Maria Begoña Vila, Volk, Kevin, Voorzaat, Piet, Voyton, Mark F., Vydra, Ekaterina, Waddy, Darryl J., Waelkens, Christoffel, Wahlgren, Glenn Michael, Walker Jr., Frederick E., Wander, Michel, Warfield, Christine K., Warner, Gerald, Wasiak, Francis C., Wasiak, Matthew F., Wehner, James, Weiler, Kevin R., Weilert, Mark, Weiss, Stanley B., Wells, Martyn, Welty, Alan D., Wheate, Lauren, Wheeler, Thomas P., White, Christy L., Whitehouse, Paul, Whiteleather, Jennifer Margaret, Whitman, William Russell, Williams, Christina C., Willmer, Christopher N. A., Willott, Chris J., Willoughby, Scott P., Wilson, Andrew, Wilson, Debra, Wilson, Donna V., Windhorst, Rogier, Wislowski, Emily Christine, Wolfe, David J., Wolfe, Michael A., Wolff, Schuyler, Wondel, Amancio, Woo, Cindy, Woods, Robert T., Worden, Elaine, Workman, William, Wright, Gillian S., Wu, Carl, Wu, Chi-Rai, Wun, Dakin D., Wymer, Kristen B., Yadetie, Thomas, Yan, Isabelle C., Yang, Keith C., Yates, Kayla L., Yeager, Christopher R., Yerger, Ethan John, Young, Erick T., Young, Gary, Yu, Gene, Yu, Susan, Zak, Dean S., Zeidler, Peter, Zepp, Robert, Zhou, Julia, Zincke, Christian A., Zonak, Stephanie, and Zondag, Elisabeth

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit., Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figures

Published
2023
Full Text
View/download PDF

45. Radiocarbon analysis reveals underestimation of soil organic carbon persistence in new-generation soil models

Author

A. S. Brunmayr, F. Hagedorn, M. Moreno Duborgel, L. I. Minich, and H. D. Graven

Subjects
Geology, QE1-996.5
Abstract

Reflecting recent advances in our understanding of soil organic carbon (SOC) turnover and persistence, a new generation of models increasingly makes the distinction between the more labile soil particulate organic matter (POM) and the more persistent mineral-associated organic matter (MAOM). Unlike the typically poorly defined conceptual pools of traditional SOC models, the POM and MAOM soil fractions can be directly measured for their carbon content and isotopic composition, allowing for fraction-specific data assimilation. However, the new-generation model predictions of POM and MAOM dynamics have not yet been validated with fraction-specific carbon and 14C observations. In this study, we evaluate five influential and actively developed new-generation models (CORPSE, MEND, Millennial, MIMICS, SOMic) with fraction-specific and bulk soil 14C measurements of 77 mineral topsoil profiles in the International Soil Radiocarbon Database (ISRaD). We find that all five models consistently overestimate the 14C content (Δ14C) of POM by 69 ‰ on average, and two out of the five models also strongly overestimate the Δ14C of MAOM by more than 80 ‰ on average, indicating that the models generally overestimate the turnover rates of SOC and do not adequately represent the long-term stabilization of carbon in soils. These results call for more widespread usage of fraction-specific carbon and 14C measurements for parameter calibration and may even suggest that some new-generation models might need to restructure or further subdivide their simulated carbon pools in order to accurately reproduce SOC dynamics.

Published
2024
Full Text
View/download PDF

47. Cryopreservation and revival of Hawaiian stony corals using isochoric vitrification.

Author

Powell-Palm, Matthew, Henley, E, Consiglio, Anthony, Lager, Claire, Chang, Brooke, Perry, Riley, Fitzgerald, Kendall, Daly, Jonathan, Rubinsky, Boris, and Hagedorn, Mary

Subjects
Animals, Vitrification, Hawaii, Cryopreservation, Anthozoa, Isoflavones, Soybean Proteins
Abstract

Corals are under siege by both local and global threats, creating a worldwide reef crisis. Cryopreservation is an important intervention measure and a vital component of the modern coral conservation toolkit, but preservation techniques are currently limited to sensitive reproductive materials that can only be obtained a few nights per year during spawning. Here, we report the successful cryopreservation and revival of cm-scale coral fragments via mL-scale isochoric vitrification. We demonstrate coral viability at 24 h post-thaw using a calibrated oxygen-uptake respirometry technique, and further show that the method can be applied in a passive, electronics-free configuration. Finally, we detail a complete prototype coral cryopreservation pipeline, which provides a platform for essential next steps in modulating post-thaw stress and initiating long-term growth. These findings pave the way towards an approach that can be rapidly deployed around the world to secure the biological genetic diversity of our vanishing coral reefs.

Published
2023

48. Costs of implementing a multi-site facilitation intervention to increase access to medication treatment for opioid use disorder.

Author

Gordon, Adam, Gustavson, Allison, Kenny, Marie, Miller, Wendy, Esmaeili, Aryan, Ackland, Princess, Clothier, Barbara, Bangerter, Ann, Noorbaloochi, Siamak, Harris, Alex, Hagedorn, Hildi, Garcia, Carla, and Bounthavong, Mark

Subjects
Cost analysis, Evidence-based practice, External facilitation, Implementation science, Medication for opioid use disorder
Abstract

BACKGROUND: The United States has been grappling with the opioid epidemic, which has resulted in over 75,000 opioid-related deaths between April 2020 and 2021. Evidence-based pharmaceutical interventions (buprenorphine, methadone, and naltrexone) are available to reduce opioid-related overdoses and deaths. However, adoption of these medications for opioid use disorder has been stifled due to individual- and system-level barriers. External facilitation is an evidence-based implementation intervention that has been used to increase access to medication for opioid use disorder (MOUD), but the implementation costs of external facilitation have not been assessed. We sought to measure the facility-level direct costs of implementing an external facilitation intervention for MOUD to provide decision makers with estimates of the resources needed to implement this evidence-based program. METHODS: We performed a cost analysis of the pre-implementation and implementation phases, including an itemization of external facilitation team and local site labor costs. We used labor estimates from the Bureau of Labor and Statistics, and sensitivity analyses were performed using labor estimates from the Veterans Health Administration (VHA) Financial Management System general ledger data. RESULTS: The average total costs for implementing an external facilitation intervention for MOUD per site was $18,847 (SD 6717) and ranged between $11,320 and $31,592. This translates to approximately $48 per patient with OUD. Sites with more encounters and participants with higher salaries in attendance had higher costs. This was driven mostly by the labor involved in planning and implementation activities. The average total cost of the pre-implementation and implementation activities were $1031 and $17,816 per site, respectively. In the sensitivity analysis, costs for VHA were higher than BLS estimates likely due to higher wages. CONCLUSIONS: Implementing external facilitation to increase MOUD prescribing may be affordable depending on the payers budget constraints. Our study reported that there were variations in the time invested at each phase of implementation and the number and type of participants involved with implementing an external facilitation intervention. Participant composition played an important role in total implementation costs, and decision makers will need to identify the most efficient and optimal number of stakeholders to involve in their implementation plans.

Published
2023

49. Grade V renal trauma management: results from the multi-institutional genito-urinary trauma study.

Author

Hakam, Nizar, Keihani, Sorena, Shaw, Nathan M, Abbasi, Behzad, Jones, Charles P, Rogers, Douglas, Wang, Sherry S, Gross, Joel A, Joyce, Ryan P, Hagedorn, Judith C, Selph, J Patrick, Sensenig, Rachel L, Moses, Rachel A, Dodgion, Christopher M, Gupta, Shubham, Mukherjee, Kaushik, Majercik, Sarah, Smith, Brian P, Broghammer, Joshua A, Schwartz, Ian, Baradaran, Nima, Zakaluzny, Scott A, Erickson, Bradley A, Miller, Brandi D, Askari, Reza, Carrick, Matthew M, Burks, Frank N, Norwood, Scott, Myers, Jeremy B, Breyer, Benjamin N, and Multi-institutional Genito-Urinary Trauma Study Group (MiGUTS)

Subjects
Multi-institutional Genito-Urinary Trauma Study Group, Urogenital System, Kidney, Humans, Multiple Trauma, Nephrectomy, Injury Severity Score, Retrospective Studies, Adult, Middle Aged, Trauma Centers, Kidney trauma, Nonoperative management, Urologic trauma, Kidney Disease, Physical Injury - Accidents and Adverse Effects, Patient Safety, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Clinical Sciences, Urology & Nephrology
Abstract

PurposeTo investigate management trends for American Association for the Surgery of Trauma (AAST) grade V renal trauma with focus on non-operative management.MethodsWe used prospectively collected data as part of the Multi-institutional Genito-Urinary Trauma Study (MiGUTS). We included patients with grade V renal trauma according to the AAST Injury Scoring Scale 2018 update. All cases submitted by participating centers with radiology images available were independently reviewed to confirm renal trauma grade. Management was classified as expectant, conservative (minimally invasive, endoscopic or percutaneous procedures), or operative (renal-related surgery).ResultsEighty patients were included, 25 of whom had complete imaging and had independent confirmation of AAST grade V renal trauma. Median age was 35 years (Interquartile range (IQR) 25-50) and 23 (92%) had blunt trauma. Ten patients (40%) were managed operatively with nephrectomy. Conservative management was used in nine patients (36%) of which six received angioembolization and three had a stent or drainage tube placed. Expectant management was followed in six (24%) patients. Transfusion requirements were progressively higher with groups requiring more aggressive treatment, and injury characteristics differed significantly across management groups in terms of hematoma size and laceration size. Vascular contrast extravasation was more likely in operatively managed patients though a statistically significant association was not found.ConclusionSuccessful use of nonoperative management for grade V injuries is used for a substantial subset of patients. Lower transfusion requirement and less severe injury radiologic phenotype appear to be important characteristics delineating this group.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results