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We study the long-standing open question of the power of unique witness in quantum protocols, which asks if UniqueQMA, a variant of QMA whose accepting witness space is 1-dimensional, is equal to QMA. We show a quantum oracle separation between UniqueQMA and QMA via an extension of the Aaronson-Kuperberg's QCMA vs QMA oracle separation. In particular, we show that any UniqueQMA protocol must make $\Omega(\sqrt{D})$ queries to a subspace phase oracle of unknown dimension $\leq D$ to "find" the subspace. This presents an obstacle to relativizing techniques in resolving this question (unlike its classical analogue - the Valiant-Vazirani theorem - which is essentially a black-box reduction) and suggests the need to study the structure of the ground space of local Hamiltonians in distilling a potential unique witness. Our techniques also yield a quantum oracle separation between QXC, the class characterizing quantum approximate counting, and QMA. Very few structural properties are known that place the complexity of local Hamiltonians in UniqueQMA. We expand this set of properties by showing that the ground energy of local Hamiltonians that satisfy the eigenstate thermalization hypothesis (ETH) can be estimated through a UniqueQMA protocol. Specifically, our protocol can be viewed as a quantum expander test in a low energy subspace of the Hamiltonian and verifies a unique entangled state in two copies of the subspace. This allows us to conclude that if UniqueQMA $\neq$ QMA, then QMA-hard Hamiltonians must violate ETH under adversarial perturbations (more accurately, under the quantum PCP conjecture if ETH only applies to extensive energy subspaces). Our results serve as evidence that chaotic local Hamiltonians, such as the SYK model, contain polynomial verifiable quantum states in their low energy regime and may be simpler than general local Hamiltonians if UniqueQMA $\neq$ QMA.

We study the sample complexity of the prototypical tasks quantum purity estimation and quantum inner product estimation. In purity estimation, we are to estimate $tr(\rho^2)$ of an unknown quantum state $\rho$ to additive error $\epsilon$. Meanwhile, for quantum inner product estimation, Alice and Bob are to estimate $tr(\rho\sigma)$ to additive error $\epsilon$ given copies of unknown quantum state $\rho$ and $\sigma$ using classical communication and restricted quantum communication. In this paper, we show a strong connection between the sample complexity of purity estimation with bounded quantum memory and inner product estimation with bounded quantum communication and unentangled measurements. We propose a protocol that solves quantum inner product estimation with $k$-qubit one-way quantum communication and unentangled local measurements using $O(median\{1/\epsilon^2,2^{n/2}/\epsilon,2^{n-k}/\epsilon^2\})$ copies of $\rho$ and $\sigma$. Our protocol can be modified to estimate the purity of an unknown quantum state $\rho$ using $k$-qubit quantum memory with the same complexity. We prove that arbitrary protocols with $k$-qubit quantum memory that estimate purity to error $\epsilon$ require $\Omega(median\{1/\epsilon^2,2^{n/2}/\sqrt{\epsilon},2^{n-k}/\epsilon^2\})$ copies of $\rho$. This indicates the same lower bound for quantum inner product estimation with one-way $k$-qubit quantum communication and classical communication, and unentangled local measurements. For purity estimation, we further improve the lower bound to $\Omega(\max\{1/\epsilon^2,2^{n/2}/\epsilon\})$ for any protocols using an identical single-copy projection-valued measurement. Additionally, we investigate a decisional variant of quantum distributed inner product estimation without quantum communication for mixed state and provide a lower bound on the sample complexity., Comment: 33 pages, 1 figure

Quantum pseudorandomness has found applications in many areas of quantum information, ranging from entanglement theory, to models of scrambling phenomena in chaotic quantum systems, and, more recently, in the foundations of quantum cryptography. Kretschmer (TQC '21) showed that both pseudorandom states and pseudorandom unitaries exist even in a world without classical one-way functions. To this day, however, all known constructions require classical cryptographic building blocks which are themselves synonymous with the existence of one-way functions, and which are also challenging to realize on realistic quantum hardware. In this work, we seek to make progress on both of these fronts simultaneously -- by decoupling quantum pseudorandomness from classical cryptography altogether. We introduce a quantum hardness assumption called the Hamiltonian Phase State (HPS) problem, which is the task of decoding output states of a random instantaneous quantum polynomial-time (IQP) circuit. Hamiltonian phase states can be generated very efficiently using only Hadamard gates, single-qubit Z-rotations and CNOT circuits. We show that the hardness of our problem reduces to a worst-case version of the problem, and we provide evidence that our assumption is plausibly fully quantum; meaning, it cannot be used to construct one-way functions. We also show information-theoretic hardness when only few copies of HPS are available by proving an approximate $t$-design property of our ensemble. Finally, we show that our HPS assumption and its variants allow us to efficiently construct many pseudorandom quantum primitives, ranging from pseudorandom states, to quantum pseudoentanglement, to pseudorandom unitaries, and even primitives such as public-key encryption with quantum keys., Comment: 64 pages, 1 figure

Analog quantum simulation allows for assessing static and dynamical properties of strongly correlated quantum systems to high precision. To perform simulations outside the reach of classical computers, accurate and reliable implementations of the anticipated Hamiltonians are required. To achieve those, characterization and benchmarking tools are a necessity. For digital quantum devices, randomized benchmarking can provide a benchmark on the average quality of the implementation of a gate set. In this work, we introduce a versatile framework for randomized analog benchmarking of bosonic and fermionic quantum devices implementing particle number preserving dynamics. The scheme makes use of the restricted operations which are native to analog simulators and other continuous variable systems. Importantly, like randomized benchmarking, it is robust against state preparation and measurement errors. We discuss the scheme's efficiency, derive theoretical performance guarantees and showcase the protocol with numerical examples., Comment: Main text 5 pages and 3 figures, references and supplementary material 16 pages and 5 figures

We prove that random quantum circuits on any geometry, including a 1D line, can form approximate unitary designs over $n$ qubits in $\log n$ depth. In a similar manner, we construct pseudorandom unitaries (PRUs) in 1D circuits in $\text{poly} \log n $ depth, and in all-to-all-connected circuits in $\text{poly} \log \log n $ depth. In all three cases, the $n$ dependence is optimal and improves exponentially over known results. These shallow quantum circuits have low complexity and create only short-range entanglement, yet are indistinguishable from unitaries with exponential complexity. Our construction glues local random unitaries on $\log n$-sized or $\text{poly} \log n$-sized patches of qubits to form a global random unitary on all $n$ qubits. In the case of designs, the local unitaries are drawn from existing constructions of approximate unitary $k$-designs, and hence also inherit an optimal scaling in $k$. In the case of PRUs, the local unitaries are drawn from existing unitary ensembles conjectured to form PRUs. Applications of our results include proving that classical shadows with 1D log-depth Clifford circuits are as powerful as those with deep circuits, demonstrating superpolynomial quantum advantage in learning low-complexity physical systems, and establishing quantum hardness for recognizing phases of matter with topological order., Comment: 12 pages, 6 figures + 46-page appendix

Random reversible and quantum circuits form random walks on the alternating group $\mathrm{Alt}(2^n)$ and unitary group $\mathrm{SU}(2^n)$, respectively. Known bounds on the spectral gap for the $t$-th moment of these random walks have inverse-polynomial dependence in both $n$ and $t$. We prove that the gap for random reversible circuits is $\Omega(n^{-3})$ for all $t\geq 1$, and the gap for random quantum circuits is $\Omega(n^{-3})$ for $t \leq \Theta(2^{n/2})$. These gaps are independent of $t$ in the respective regimes. We can further improve both gaps to $n^{-1}/\mathrm{polylog}(n, t)$ for $t\leq 2^{\Theta(n)}$, which is tight up to polylog factors. Our spectral gap results have a number of consequences: 1) Random reversible circuits with $\mathcal{O}(n^4 t)$ gates form multiplicative-error $t$-wise independent (even) permutations for all $t\geq 1$; for $t \leq \Theta(2^{n/6.1})$, we show that $\tilde{\mathcal{O}}(n^2 t)$ gates suffice. 2) Random quantum circuits with $\mathcal{O}(n^4 t)$ gates form multiplicative-error unitary $t$-designs for $t \leq \Theta(2^{n/2})$; for $t\leq \Theta(2^{2n/5})$, we show that $\tilde{\mathcal{O}}(n^2t)$ gates suffice. 3) The robust quantum circuit complexity of random circuits grows linearly for an exponentially long time, proving the robust Brown--Susskind conjecture [BS18,BCHJ+21]. Our spectral gap bounds are proven by reducing random quantum circuits to a more structured walk: a modification of the ``$\mathrm{PFC}$ ensemble'' from [MPSY24] together with an expander on the alternating group due to Kassabov [Kas07a], for which we give an efficient implementation using reversible circuits. In our reduction, we approximate the structured walk with local random circuits without losing the gap, which uses tools from the study of frustration-free Hamiltonians., Comment: 80 pages, 5 figures, v2: added references and minor changes in the presentation

Quantum complexity measures the difficulty of realizing a quantum process, such as preparing a state or implementing a unitary. We present an approach to quantifying the thermodynamic resources required to implement a process if the process's complexity is restricted. We focus on the prototypical task of information erasure, or Landauer erasure, wherein an n-qubit memory is reset to the all-zero state. We show that the minimum thermodynamic work required to reset an arbitrary state, via a complexity-constrained process, is quantified by the state's complexity entropy. The complexity entropy therefore quantifies a trade-off between the work cost and complexity cost of resetting a state. If the qubits have a nontrivial (but product) Hamiltonian, the optimal work cost is determined by the complexity relative entropy. The complexity entropy quantifies the amount of randomness a system appears to have to a computationally limited observer. Similarly, the complexity relative entropy quantifies such an observer's ability to distinguish two states. We prove elementary properties of the complexity (relative) entropy and determine the complexity entropy's behavior under random circuits. Also, we identify information-theoretic applications of the complexity entropy. The complexity entropy quantifies the resources required for data compression if the compression algorithm must use a restricted number of gates. We further introduce a complexity conditional entropy, which arises naturally in a complexity-constrained variant of information-theoretic decoupling. Assuming that this entropy obeys a conjectured chain rule, we show that the entropy bounds the number of qubits that one can decouple from a reference system, as judged by a computationally bounded referee. Overall, our framework extends the resource-theoretic approach to thermodynamics to integrate a notion of time, as quantified by complexity., Comment: 15.5 pages (6 figures) + appendices (42 pages)

Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective studies, artificial intelligence (AI) has proven to be helpful for enhancing melanoma detection. However, there are few prospective studies confirming these promising results. Existing studies are limited by low sample sizes, too homogenous datasets, or lack of inclusion of rare melanoma subtypes, preventing a fair and thorough evaluation of AI and its generalizability, a crucial aspect for its application in the clinical setting. Therefore, we assessed 'All Data are Ext' (ADAE), an established open-source ensemble algorithm for detecting melanomas, by comparing its diagnostic accuracy to that of dermatologists on a prospectively collected, external, heterogeneous test set comprising eight distinct hospitals, four different camera setups, rare melanoma subtypes, and special anatomical sites. We advanced the algorithm with real test-time augmentation (R-TTA, i.e. providing real photographs of lesions taken from multiple angles and averaging the predictions), and evaluated its generalization capabilities. Overall, the AI showed higher balanced accuracy than dermatologists (0.798, 95% confidence interval (CI) 0.779-0.814 vs. 0.781, 95% CI 0.760-0.802; p<0.001), obtaining a higher sensitivity (0.921, 95% CI 0.900- 0.942 vs. 0.734, 95% CI 0.701-0.770; p<0.001) at the cost of a lower specificity (0.673, 95% CI 0.641-0.702 vs. 0.828, 95% CI 0.804-0.852; p<0.001). As the algorithm exhibited a significant performance advantage on our heterogeneous dataset exclusively comprising melanoma-suspicious lesions, AI may offer the potential to support dermatologists particularly in diagnosing challenging cases.

Background: Convolutional neural network (CNN)-based melanoma classifiers face several challenges that limit their usefulness in clinical practice. Objective: To investigate the impact of multiple real-world dermoscopic views of a single lesion of interest on a CNN-based melanoma classifier. Methods: This study evaluated 656 suspected melanoma lesions. Classifier performance was measured using area under the receiver operating characteristic curve (AUROC), expected calibration error (ECE) and maximum confidence change (MCC) for (I) a single-view scenario, (II) a multiview scenario using multiple artificially modified images per lesion and (III) a multiview scenario with multiple real-world images per lesion. Results: The multiview approach with real-world images significantly increased the AUROC from 0.905 (95% CI, 0.879-0.929) in the single-view approach to 0.930 (95% CI, 0.909-0.951). ECE and MCC also improved significantly from 0.131 (95% CI, 0.105-0.159) to 0.072 (95% CI: 0.052-0.093) and from 0.149 (95% CI, 0.125-0.171) to 0.115 (95% CI: 0.099-0.131), respectively. Comparing multiview real-world to artificially modified images showed comparable diagnostic accuracy and uncertainty estimation, but significantly worse robustness for the latter. Conclusion: Using multiple real-world images is an inexpensive method to positively impact the performance of a CNN-based melanoma classifier.

Recently, the dynamics of quantum systems that involve both unitary evolution and quantum measurements have attracted attention due to the exotic phenomenon of measurement-induced phase transitions. The latter refers to a sudden change in a property of a state of $n$ qubits, such as its entanglement entropy, depending on the rate at which individual qubits are measured. At the same time, quantum complexity emerged as a key quantity for the identification of complex behaviour in quantum many-body dynamics. In this work, we investigate the dynamics of the quantum state complexity in monitored random circuits, where $n$ qubits evolve according to a random unitary circuit and are individually measured with a fixed probability at each time step. We find that the evolution of the exact quantum state complexity undergoes a phase transition when changing the measurement rate. Below a critical measurement rate, the complexity grows at least linearly in time until saturating to a value $e^{\Omega(n)}$. Above, the complexity does not exceed $\operatorname{poly}(n)$. In our proof, we make use of percolation theory to find paths along which an exponentially long quantum computation can be run below the critical rate, and to identify events where the state complexity is reset to zero above the critical rate. We lower bound the exact state complexity in the former regime using recently developed techniques from algebraic geometry. Our results combine quantum complexity growth, phase transitions, and computation with measurements to help understand the behavior of monitored random circuits and to make progress towards determining the computational power of measurements in many-body systems., Comment: 20 pages, 3 figures

In this work, we show that learning the output distributions of brickwork random quantum circuits is average-case hard in the statistical query model. This learning model is widely used as an abstract computational model for most generic learning algorithms. In particular, for brickwork random quantum circuits on $n$ qubits of depth $d$, we show three main results: - At super logarithmic circuit depth $d=\omega(\log(n))$, any learning algorithm requires super polynomially many queries to achieve a constant probability of success over the randomly drawn instance. - There exists a $d=O(n)$, such that any learning algorithm requires $\Omega(2^n)$ queries to achieve a $O(2^{-n})$ probability of success over the randomly drawn instance. - At infinite circuit depth $d\to\infty$, any learning algorithm requires $2^{2^{\Omega(n)}}$ many queries to achieve a $2^{-2^{\Omega(n)}}$ probability of success over the randomly drawn instance. As an auxiliary result of independent interest, we show that the output distribution of a brickwork random quantum circuit is constantly far from any fixed distribution in total variation distance with probability $1-O(2^{-n})$, which confirms a variant of a conjecture by Aaronson and Chen., Comment: 57 pages

We prove new lower bounds on the growth of robust quantum circuit complexity -- the minimal number of gates $C_{\delta}(U)$ to approximate a unitary $U$ up to an error of $\delta$ in operator norm distance. More precisely we show two bounds for random quantum circuits with local gates drawn from a subgroup of $SU(4)$. First, for $\delta=\Theta(2^{-n})$, we prove a linear growth rate: $C_{\delta}\geq d/\mathrm{poly}(n)$ for random quantum circuits on $n$ qubits with $d\leq 2^{n/2}$ gates. Second, for $ \delta=\Omega(1)$, we prove a square-root growth of complexity: $C_{\delta}\geq \sqrt{d}/\mathrm{poly}(n)$ for all $d\leq 2^{n/2}$. Finally, we provide a simple conjecture regarding the Fourier support of randomly drawn Boolean functions that would imply linear growth for constant $\delta$. While these results follow from bounds on the moments of random quantum circuits, we do not make use of existing results on the generation of unitary $t$-designs. Instead, we bound the moments of an auxiliary random walk on the diagonal unitaries acting on phase states. In particular, our proof is comparably short and self-contained., Comment: 13 pages, 1 figure, v2: modified main theorem due to a gap in v1

Although artificial intelligence (AI) systems have been shown to improve the accuracy of initial melanoma diagnosis, the lack of transparency in how these systems identify melanoma poses severe obstacles to user acceptance. Explainable artificial intelligence (XAI) methods can help to increase transparency, but most XAI methods are unable to produce precisely located domain-specific explanations, making the explanations difficult to interpret. Moreover, the impact of XAI methods on dermatologists has not yet been evaluated. Extending on two existing classifiers, we developed an XAI system that produces text and region based explanations that are easily interpretable by dermatologists alongside its differential diagnoses of melanomas and nevi. To evaluate this system, we conducted a three-part reader study to assess its impact on clinicians' diagnostic accuracy, confidence, and trust in the XAI-support. We showed that our XAI's explanations were highly aligned with clinicians' explanations and that both the clinicians' trust in the support system and their confidence in their diagnoses were significantly increased when using our XAI compared to using a conventional AI system. The clinicians' diagnostic accuracy was numerically, albeit not significantly, increased. This work demonstrates that clinicians are willing to adopt such an XAI system, motivating their future use in the clinic.

We provide practical and powerful schemes for learning many properties of an unknown n-qubit quantum state using a sparing number of copies of the state. Specifically, we present a depth-modulated randomized measurement scheme that interpolates between two known classical shadows schemes based on random Pauli measurements and random Clifford measurements. These can be seen within our scheme as the special cases of zero and infinite depth, respectively. We focus on the regime where depth scales logarithmically in n and provide evidence that this retains the desirable properties of both extremal schemes whilst, in contrast to the random Clifford scheme, also being experimentally feasible. We present methods for two key tasks; estimating expectation values of certain observables from generated classical shadows and, computing upper bounds on the depth-modulated shadow norm, thus providing rigorous guarantees on the accuracy of the output estimates. We consider observables that can be written as a linear combination of poly(n) Paulis and observables that can be written as a low bond dimension matrix product operator. For the former class of observables both tasks are solved efficiently in n. For the latter class, we do not guarantee efficiency but present a method that works in practice; by variationally computing a heralded approximate inverses of a tensor network that can then be used for efficiently executing both these tasks., Comment: 22 pages, 12 figures. Version 2: new MPS variational inversion algorithm and new numerics

The task of learning a probability distribution from samples is ubiquitous across the natural sciences. The output distributions of local quantum circuits form a particularly interesting class of distributions, of key importance both to quantum advantage proposals and a variety of quantum machine learning algorithms. In this work, we provide an extensive characterization of the learnability of the output distributions of local quantum circuits. Our first result yields insight into the relationship between the efficient learnability and the efficient simulatability of these distributions. Specifically, we prove that the density modelling problem associated with Clifford circuits can be efficiently solved, while for depth $d=n^{\Omega(1)}$ circuits the injection of a single $T$-gate into the circuit renders this problem hard. This result shows that efficient simulatability does not imply efficient learnability. Our second set of results provides insight into the potential and limitations of quantum generative modelling algorithms. We first show that the generative modelling problem associated with depth $d=n^{\Omega(1)}$ local quantum circuits is hard for any learning algorithm, classical or quantum. As a consequence, one cannot use a quantum algorithm to gain a practical advantage for this task. We then show that, for a wide variety of the most practically relevant learning algorithms -- including hybrid-quantum classical algorithms -- even the generative modelling problem associated with depth $d=\omega(\log(n))$ Clifford circuits is hard. This result places limitations on the applicability of near-term hybrid quantum-classical generative modelling algorithms., Comment: 5+12 pages, 3 figures

The applications of random quantum circuits range from quantum computing and quantum many-body systems to the physics of black holes. Many of these applications are related to the generation of quantum pseudorandomness: Random quantum circuits are known to approximate unitary $t$-designs. Unitary $t$-designs are probability distributions that mimic Haar randomness up to $t$th moments. In a seminal paper, Brand\~{a}o, Harrow and Horodecki prove that random quantum circuits on qubits in a brickwork architecture of depth $O(n t^{10.5})$ are approximate unitary $t$-designs. In this work, we revisit this argument, which lower bounds the spectral gap of moment operators for local random quantum circuits by $\Omega(n^{-1}t^{-9.5})$. We improve this lower bound to $\Omega(n^{-1}t^{-4-o(1)})$, where the $o(1)$ term goes to $0$ as $t\to\infty$. A direct consequence of this scaling is that random quantum circuits generate approximate unitary $t$-designs in depth $O(nt^{5+o(1)})$. Our techniques involve Gao's quantum union bound and the unreasonable effectiveness of the Clifford group. As an auxiliary result, we prove fast convergence to the Haar measure for random Clifford unitaries interleaved with Haar random single qubit unitaries., Comment: 21 pages, 1 figure, v2: typos corrected and new references, v3: minor corrections, version accepted in Quantum

One of the central foundational questions of physics is to identify what makes a system quantum as opposed to classical. One seminal notion of classicality of a quantum system is the existence of a non-contextual hidden variable model as introduced in the early work by Bell, Kochen and Specker. In quantum optics, the non-negativity of the Wigner function is a ubiquitous notion of classicality. In this work we establish an equivalence between these two concepts. In particular, we show that any non-contextual hidden variable model for Gaussian quantum optics has an alternative non-negative Wigner function description. Conversely, it was known that the Wigner representation provides a non-negative non-contextual description of Gaussian quantum optics. It follows that contextuality and Wigner negativity are equivalent notions of non-classicality and equivalent resources for this quantum subtheory. In particular, both contextuality and Wigner negativity are necessary for a computational speed-up of quantum Gaussian optics. At the technical level, our result holds true for any subfamily of Gaussian measurements that include homodyne measurements, i.e., measurements of standard quadrature observables., Comment: 9 pages, no figues

Quantum complexity is emerging as a key property of many-body systems, including black holes, topological materials, and early quantum computers. A state's complexity quantifies the number of computational gates required to prepare the state from a simple tensor product. The greater a state's distance from maximal complexity, or "uncomplexity," the more useful the state is as input to a quantum computation. Separately, resource theories -- simple models for agents subject to constraints -- are burgeoning in quantum information theory. We unite the two domains, confirming Brown and Susskind's conjecture that a resource theory of uncomplexity can be defined. The allowed operations, fuzzy operations, are slightly random implementations of two-qubit gates chosen by an agent. We formalize two operational tasks, uncomplexity extraction and expenditure. Their optimal efficiencies depend on an entropy that we engineer to reflect complexity. We also present two monotones, uncomplexity measures that decline monotonically under fuzzy operations, in certain regimes. This work unleashes on many-body complexity the resource-theory toolkit from quantum information theory., Comment: Published version