38 results on '"Hafdi, Melanie"'
Search Results
2. Prevention of dementia using mobile phone applications (PRODEMOS): a multinational, randomised, controlled effectiveness–implementation trial
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Witvliet, Patrick, Hoitink, Mart, van de Groep, Bram, Liu, Hongmei, Ge, Siqi, He, Mingyue, Li, Cancan, Jian, Xuening, Jiang, Bin, Sun, Haixin, Ru, Xiaojuan, Sun, Dongling, Lian, Tenghong, Zhang, Weijiao, Zhang, Wenjing, Qi, Jing, Li, Jinghui, Guan, Huiying, Luo, Dongmei, Zhang, Weijia, Yue, Hao, Zheng, Zijing, Zeng, Qiang, Yang, Huangdai, Tang, Yanyan, Tao, Tianqi, Song, Yan, Meng, Xiaosheng, Zhu, Sirui, Jia, Dongmei, Li, Mo, Li, Wenjie, Mu, Haiyan, Jiang, Wenjing, Gao, Wenchao, Hu, Yueqing, Wang, Guohua, Xu, Xizhu, Zhang, Yichun, Li, Dong, Zhang, Xiaoyu, Guo, Xiuhua, Ye, Xiaoyan, Wei, Xi, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Song, Manshu, Andrieu, Sandrine, Barnes, Linda, Birck, Cindy, Brooks, Rachael, Coley, Nicola, Eggink, Esmé, Georges, Jean, Hafdi, Melanie, van Gool, Willem A, Handels, Ron, Hou, Haifeng, Lyu, Jihui, Niu, Yixuan, Song, Libin, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Yu, Yueyi, Zhang, Jinxia, Zhang, Wei, Brayne, Carol, Wang, Wei, and Richard, Edo
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- 2024
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3. July Literature Synopses
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Quinn, Terence J. and Hafdi, Melanie
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- 2023
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4. Atherosclerotic risk is associated with cerebral perfusion – A cross-sectional study using arterial spin labeling MRI
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Hafdi, Melanie, Mutsaerts, Henk JMM, Petr, Jan, Richard, Edo, and van Dalen, Jan Willem
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- 2022
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5. Primary stroke prevention worldwide: translating evidence into action
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Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Owolabi, Mayowa O, Thrift, Amanda G, Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D, Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T, Roth, Greg, Gall, Seana L, Beare, Richard, Phan, Thanh G, Mikulik, Robert, Akinyemi, Rufus O, Norrving, Bo, Brainin, Michael, and Feigin, Valery L
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- 2022
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6. Association of Benzodiazepine and Anticholinergic Drug Usage With Incident Dementia: A Prospective Cohort Study of Community-Dwelling Older Adults
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Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Beishuizen, Cathrien R.L., Moll van Charante, Eric P., Richard, Edo, and van Gool, Willem A.
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- 2020
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7. Physical and brain frailty in ischaemic stroke or TIA: Shared occurrence and outcomes. A cohort study
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Taylor-Rowan, Martin, primary, Hafdi, Melanie, additional, Drozdowska, Bogna, additional, Elliott, Emma, additional, Wardlaw, Joanna, additional, and Quinn, Terence J, additional
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- 2023
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8. Physical and brain frailty in ischaemic stroke or TIA: Shared occurrence and outcomes. A cohort study
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Taylor-Rowan, Martin, Hafdi, Melanie, Drozdowska, Bogna, Elliott, Emma, Wardlaw, Joanna, and Quinn, Terence j
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Background:There is increasing interest in the concept of frailty in stroke, including both physical frailty and imaging-evidence of brain frailty. We aimed to establish the prevalence of brain frailty in stroke survivors as well as the concurrent and predictive validity of various frailty measures against long-term cognitive outcomes.Methods:We included consecutively admitted stroke or transient ischaemic attack (TIA) survivors from participating stroke centres. Baseline CT scans were used to generate an overall brain frailty score for each participant. We measured frailty via the Rockwood frailty index, and a Fried frailty screening tool. Presence of major or minor neurocognitive disorder at 18-months following stroke or TIA was established via a multicomponent assessment. Prevalence of brain frailty was established based upon observed percentages within groups defined by frailty status (robust, pre-frail, frail). We assessed the concurrent validity of brain frailty and frailty scales via Spearman’s rank correlation. We conducted multivariable logistic regression analyses, controlling for age, sex, baseline education and stroke severity, to evaluate association between each frailty measure and 18-month cognitive impairment.Results:Three-hundred-forty-one stroke survivors participated. Three-quarters of people who were frail had moderate-severe brain frailty and prevalence increased according to frailty status. Brain frailty was weakly correlated with Rockwood frailty (Rho: 0.336; p Conclusions:There appears to be value in the assessment of both physical and brain frailty in patients with ischaemic stroke and TIA. Both are associated with adverse cognitive outcomes and physical frailty remains important when assessing cognitive outcomes.
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- 2023
9. sj-docx-1-eso-10.1177_23969873231186480 – Supplemental material for Physical and brain frailty in ischaemic stroke or TIA: Shared occurrence and outcomes. A cohort study
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Taylor-Rowan, Martin, Hafdi, Melanie, Drozdowska, Bogna, Elliott, Emma, Wardlaw, Joanna, and Quinn, Terence J
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Neurology and Neuromuscular Diseases ,FOS: Clinical medicine ,Cardiology ,Medicine - Abstract
Supplemental material, sj-docx-1-eso-10.1177_23969873231186480 for Physical and brain frailty in ischaemic stroke or TIA: Shared occurrence and outcomes. A cohort study by Martin Taylor-Rowan, Melanie Hafdi, Bogna Drozdowska, Emma Elliott, Joanna Wardlaw and Terence J Quinn in European Stroke Journal
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- 2023
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10. Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia
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Kwan, Joseph, additional, Hafdi, Melanie, additional, Chiang, Lorraine L W, additional, Myint, Phyo K, additional, Wong, Li Siang, additional, and Quinn, Terry J, additional
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- 2022
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11. Comparative validity of informant tools for assessing pre-stroke cognitive impairment
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Taylor-Rowan, Martin, McGuire, Lucy, Hafdi, Melanie, Evans, Jonathan, Stott, David J., Wetherall, Kirsty, Elliott, Emma, Drozdowska, Bogna, and Quinn, Terence J.
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Objectives:\ud Various informant-based questionnaires are used in clinical practice to screen for pre-stroke cognitive problems. However, there is no guidance on which tool should be preferred. We compared the validity of the two most commonly used informant-based tools.\ud \ud Methods:\ud We recruited consecutively admitted stroke patients. Patients' informants completed the Informant Questionnaire for Cognitive Decline in the Elderly Short Form (IQCODE-SF, 16-item) and Ascertain Dementia 8 (AD8). We assessed construct validity (accuracy) against a semi-structured clinical interview for dementia or mild cognitive impairment (MCI), describing test accuracy metrics and comparing area under ROC curves (AUROC). We described criterion validity by evaluating associations between test scores and neuroimaging markers of dementia and overall ‘brain frailty’. Finally, we described prognostic validity comparing ROC curves for 18-month clinical outcomes of dementia, death, stroke, and disability.\ud \ud Results:\ud One-hundred-thirty-seven patient-informant dyads were recruited. At usual clinical cut-points, the IQCODE-SF had comparable sensitivity to the AD8 (both = 92%) for pre-stroke dementia, but superior specificity (IQCODE-SF: 82% vs. AD8: 58%). Youden index suggested that the optimal AD8 threshold for diagnosis of dementia is ≥4. The IQCODE-SF demonstrated stronger associations with markers of generalised and medial-temporal lobe atrophy, neurovascular disease, and overall brain frailty. IQCODE-SF also demonstrated greater accuracy for predicting future dementia (IQCODE-SF AUROC = 0.903, 95% CI = 0.798–1.00; AD8 AUROC = 0.821, 95% CI = 0.664–0.977).\ud \ud Conclusions:\ud Both IQCODE-SF and AD8 are valid measures of pre-stroke dementia. Higher cut points for AD8 may improve performance in the acute stroke setting. Based on consistent superiority across a range of validity analyses, IQCODE-SF may be preferable to AD8 for pre-stroke dementia screening.
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- 2022
12. Attitudes and views on healthy lifestyle interventions for the prevention of dementia and cardiovascular disease among older people with low socioeconomic status: a qualitative study in the Netherlands
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Eggink, E., Hafdi, Melanie, Hoevenaar-Blom, M.P., Richard, E., Moll- van Charante, E., Eggink, E., Hafdi, Melanie, Hoevenaar-Blom, M.P., Richard, E., and Moll- van Charante, E.
- Abstract
Contains fulltext : 247910.pdf (Publisher’s version ) (Open Access)
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- 2022
13. Attitudes and views on healthy lifestyle interventions for the prevention of dementia and cardiovascular disease among older people with low socioeconomic status: a qualitative study in the Netherlands
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Eggink, Esmé, primary, Hafdi, Melanie, additional, Hoevenaar-Blom, Marieke P, additional, Richard, Edo, additional, and Moll van Charante, Eric P, additional
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- 2022
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14. Primary stroke prevention worldwide: translating evidence into action
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Owolabi, Mayowa O, Thrift, Amanda G, Mahal, Ajay, Ishida, Marie, Martins, Sheila, Pandian, Jeyaraj, Yaria, Joseph, Gall, Seana L, Beare, Richard, Phan, Thanh G, Akinyemi, Rufus O, Norrving, Bo, Brainin, Michael, Feigin, Valery L, Johnson, Walter D, Phan, Hoang T, Roth, Greg, Mikulik, Robert, Demarin, Vida, Ferede Abera, Semaw, Addissie, Adamu, Adebayo, Oluwadamilola, Olufemi Adeleye, Amos, Adilbekov, Yerzhan, Adilbekova, Bibigul, Armel, Thierry, Diana Aguiar de Sousa, Adoukonou, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Andonova, Silva, Emmanuel Awoniyi, Foloruso, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Beretta, Simone, Berkowitz, Aaron, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Tedim Cruz, Vitor, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Dempsey, Robert, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S, Endres, Matthias, Fischer, Urs, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Kolapo Hamzat, T Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kravchenko, Michael, Krishnamurthi, Rita V, Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M, Kang Law, Zhe, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S, Lindsay, Patrice, Andrade Lotufo, Paulo, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romerom, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Murphy, Sean, Imran Musa, Kamarul, Abanto, Carlos, Dichigans, Martin, and Bath, Philip
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Public Health, Environmental and Occupational Health - Abstract
Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.
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- 2022
15. Primary stroke prevention worldwide:translating evidence into action
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Owolabi, Mayowa O., Thrift, Amanda G., Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D., Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T., Roth, Greg, Gall, Seana L., Beare, Richard, Phan, Thanh G., Mikulik, Robert, Akinyemi, Rufus O., Norrving, Bo, Brainin, Michael, Feigin, Valery L., Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Oguntoye, Stroke Experts Collaboration Group, Owolabi M.O., Thrift A.G., Mahal A., Ishida M., Martins S., Johnson W.D., Pandian J., Abd-Allah F., Yaria J., Phan H.T., Roth G., Gall S.L., Beare R., Phan T.G., Mikulik R., Akinyemi R.O., Norrving B., Brainin M., Feigin V.L., Abanto C., Abera S.F., Addissie A., Adebayo O., Adeleye A.O., Adilbekov Y., Adilbekova B., Adoukonou T.A., Aguiar de Sousa D., Ajagbe T., Akhmetzhanova Z., Akpalu A., Alvarez Ahlgren J., Ameriso S., Andonova S., Awoniyi F.E., Bakhiet M., Barboza M., Basri H., Bath P., Bello O., Bereczki D., Beretta S., Berkowitz A., Bernabe-Ortiz A., Bernhardt J., Berzina G., Bisharyan M., Bovet P., Budincevic H., Cadilhac D., Caso V., Chen C., Chin J., Chwojnicki K., Conforto A., Cruz V.T., D'Amelio M., Danielyan K., Davis S., Demarin V., Dempsey R., Dichgans M., Dokova K., Donnan G., Elkind M.S., Endres M., Fischer U., Gankpe F., Gaye Saavedra A., Gil A., Giroud M., Gnedovskaya E., Hachinski V., Hafdi M., Hamadeh R., Hamzat T.K., Hankey G., Heldner M., Ibrahim E.A., Ibrahim N.M., Inoue M., Jee S., Jeng J.-S., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Khan T., Kiechl S., Kondybayeva A., Korv J., Kravchenko M., Krishnamurthi R.V., Kruja J., Lakkhanaloet M., Langhorne P., Lavados P.M., Law Z.K., Lawal A., Lazo-Porras M., Lebedynets D., Lee T.-H., Leung T., Liebeskind D.S., Lindsay P., Lopez-Jaramillo P., Lotufo P.A., Machline-Carrion J., Makanjuola A., Markus H.S., Marquez-Romero J.M., Medina M., Medukhanova S., Mehndiratta M.M., Merkin A., Mirrakhimov E., Mohl S., Moscoso-Porras M., Muller-Stierlin A., Murphy S., Musa K.I., Nasreldein A., Nogueira R.G., Nolte C., Noubiap J.J., Novarro-Escudero N., Ogun Y., Oguntoye R.A., Oraby M.I., Osundina M., Ovbiagele B., Orken D.N., Ozdemir A.O., Ozturk S., Paccot M., Phromjai J., Piradov P., Platz T., Potpara T., Ranta A., Rathore F., Richard E., Sacco R.L., Sahathevan R., Santos Carquin I., Saposnik G., Sarfo F.S., Sharma M., Sheth K., Shobhana A., Suwanwela N., Svyato I., Sylaja P.N., Tao X., Thakur K.T., Toni D., Topcuoglu M.A., Torales J., Towfighi A., Truelsen T.C., Tsiskaridze A., Tulloch-Reid M., Useche N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K.W., Wang W., Wijeratne T., Wolfe C., Yifru Y.M., Yock-Corrales A., Yonemoto N., Yperzeele L., and Zhang P.
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Global Burden of Disease ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Neurology ,Medicine ,030212 general & internal medicine ,Stroke ,Health policy ,Cause of death ,Entire population ,Health professionals ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Neurologija ,medicine.disease ,3. Good health ,Action (philosophy) ,Stroke prevention ,Occlusive Cerebrovascular Disease ,Life course approach ,Human medicine ,business ,030217 neurology & neurosurgery - Abstract
Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.
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- 2022
16. Design and Development of a Mobile Health (mHealth) Platform for Dementia Prevention in the Prevention of Dementia by Mobile Phone Applications (PRODEMOS) Project
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Hafdi, Melanie, primary, Eggink, Esmé, additional, Hoevenaar-Blom, Marieke P., additional, Witvliet, M. Patrick, additional, Andrieu, Sandrine, additional, Barnes, Linda, additional, Brayne, Carol, additional, Brooks, Rachael, additional, Coley, Nicola, additional, Georges, Jean, additional, van der Groep, Abraham, additional, van Marwijk, Harm, additional, van der Meijden, Mark, additional, Song, Libin, additional, Song, Manshu, additional, Wang, Youxin, additional, Wang, Wenzhi, additional, Wang, Wei, additional, Wimo, Anders, additional, Ye, Xiaoyan, additional, Moll van Charante, Eric P., additional, and Richard, Edo, additional
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- 2021
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17. Multidomain interventions for the prevention of dementia and cognitive decline: A Cochrane systematic review and meta‐analysis
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Hafdi, Melanie, primary, Hoevenaar‐Blom, Marieke P, additional, and Richard, Edo, additional
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- 2021
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18. Multi-domain interventions for the prevention of dementia and cognitive decline
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Hafdi, Melanie, additional, Hoevenaar-Blom, Marieke P., additional, and Richard, Edo, additional
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- 2021
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19. European Stroke Organisation and European Academy of Neurology joint guidelines on post‐stroke cognitive impairment
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Quinn, Terence J., primary, Richard, Edo, additional, Teuschl, Yvonne, additional, Gattringer, Thomas, additional, Hafdi, Melanie, additional, O'Brien, John T., additional, Merriman, Niamh, additional, Gillebert, Celine, additional, Huygelier, Hanne, additional, Verdelho, Ana, additional, Schmidt, Reinhold, additional, Ghaziani, Emma, additional, Forchammer, Hysse, additional, Pendlebury, Sarah T., additional, Bruffaerts, Rose, additional, Mijajlovic, Milija, additional, Drozdowska, Bogna A., additional, Ball, Emily, additional, and Markus, Hugh S., additional
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- 2021
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20. European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, primary, Richard, Edo, additional, Teuschl, Yvonne, additional, Gattringer, Thomas, additional, Hafdi, Melanie, additional, O’Brien, John T, additional, Merriman, Niamh, additional, Gillebert, Celine, additional, Huyglier, Hanne, additional, Verdelho, Ana, additional, Schmidt, Reinhold, additional, Ghaziani, Emma, additional, Forchammer, Hysse, additional, Pendlebury, Sarah T, additional, Bruffaerts, Rose, additional, Mijajlovic, Milija, additional, Drozdowska, Bogna A, additional, Ball, Emily, additional, and Markus, Hugh S, additional
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- 2021
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21. Praktijkvariatie in aanvullend onderzoek bij dementie
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Hafdi, Melanie, Richard, Edo, van Gool, Sophie E., van Charante, Eric P. Moll, van Gool, W. A. Pim, Graduate School, Neurology, APH - Health Behaviors & Chronic Diseases, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neurovascular Disorders, General practice, Public and occupational health, ACS - Diabetes & metabolism, APH - Personalized Medicine, APH - Mental Health, and APH - Methodology
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- 2021
22. Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial
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Eggink, Esmé, primary, Hafdi, Melanie, additional, Hoevenaar-Blom, Marieke P, additional, Song, Manshu, additional, Andrieu, Sandrine, additional, Barnes, Linda E, additional, Birck, Cindy, additional, Brooks, Rachael L, additional, Coley, Nicola, additional, Ford, Elizabeth, additional, Georges, Jean, additional, van der Groep, Abraham, additional, van Gool, Willem A, additional, Handels, Ron, additional, Hou, Haifeng, additional, Li, Dong, additional, Liu, Hongmei, additional, Lyu, Jihui, additional, van Marwijk, Harm, additional, van der Meijden, Mark, additional, Niu, Yixuan, additional, Sadhwani, Shanu, additional, Wang, Wenzhi, additional, Wang, Youxin, additional, Wimo, Anders, additional, Ye, Xiaoyan, additional, Yu, Yueyi, additional, Zeng, Qiang, additional, Zhang, Wei, additional, Wang, Wei, additional, Brayne, Carol, additional, Moll van Charante, Eric P, additional, and Richard, Edo, additional
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- 2021
- Full Text
- View/download PDF
23. sj-pdf-3-eso-10.1177_23969873211042192 – Supplemental Material for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O’Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Subjects
FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental Material, sj-pdf-3-eso-10.1177_23969873211042192 for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment by Terence J Quinn, Edo Richard, Yvonne Teuschl, Thomas Gattringer, Melanie Hafdi, John T O’Brien, Niamh Merriman, Celine Gillebert, Hanne Huyglier, Ana Verdelho, Reinhold Schmidt, Emma Ghaziani, Hysse Forchammer, Sarah T Pendlebury, Rose Bruffaerts, Milija Mijajlovic, Bogna A Drozdowska, Emily Ball and Hugh S Markus in European Stroke Journal
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- 2021
- Full Text
- View/download PDF
24. sj-pdf-1-eso-10.1177_23969873211042192 – Supplemental Material for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O’Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Subjects
FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental Material, sj-pdf-1-eso-10.1177_23969873211042192 for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment by Terence J Quinn, Edo Richard, Yvonne Teuschl, Thomas Gattringer, Melanie Hafdi, John T O’Brien, Niamh Merriman, Celine Gillebert, Hanne Huyglier, Ana Verdelho, Reinhold Schmidt, Emma Ghaziani, Hysse Forchammer, Sarah T Pendlebury, Rose Bruffaerts, Milija Mijajlovic, Bogna A Drozdowska, Emily Ball and Hugh S Markus in European Stroke Journal
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- 2021
- Full Text
- View/download PDF
25. sj-pdf-2-eso-10.1177_23969873211042192 – Supplemental Material for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O’Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Subjects
FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental Material, sj-pdf-2-eso-10.1177_23969873211042192 for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment by Terence J Quinn, Edo Richard, Yvonne Teuschl, Thomas Gattringer, Melanie Hafdi, John T O’Brien, Niamh Merriman, Celine Gillebert, Hanne Huyglier, Ana Verdelho, Reinhold Schmidt, Emma Ghaziani, Hysse Forchammer, Sarah T Pendlebury, Rose Bruffaerts, Milija Mijajlovic, Bogna A Drozdowska, Emily Ball and Hugh S Markus in European Stroke Journal
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- 2021
- Full Text
- View/download PDF
26. sj-pdf-4-eso-10.1177_23969873211042192 – Supplemental Material for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O’Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Subjects
FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental Material, sj-pdf-4-eso-10.1177_23969873211042192 for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment by Terence J Quinn, Edo Richard, Yvonne Teuschl, Thomas Gattringer, Melanie Hafdi, John T O’Brien, Niamh Merriman, Celine Gillebert, Hanne Huyglier, Ana Verdelho, Reinhold Schmidt, Emma Ghaziani, Hysse Forchammer, Sarah T Pendlebury, Rose Bruffaerts, Milija Mijajlovic, Bogna A Drozdowska, Emily Ball and Hugh S Markus in European Stroke Journal
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- 2021
- Full Text
- View/download PDF
27. Design and development of a mobile health (mHealth) platform for dementia prevention in the prevention of dementia by mobile phone applications (PRODEMOS) project
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Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, PRODEMOS consortium, Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, and PRODEMOS consortium
- Abstract
Background: Mobile health (mHealth) has the potential to bring preventive healthcare within reach of populations with limited access to preventive services, by delivering personalized support at low cost. Although numerous mHealth interventions are available, very few have been developed following an evidence-based rationale or have been tested for efficacy. This article describes the systematic development of a coach-supported mHealth application to improve healthy lifestyles for the prevention of dementia and cardiovascular disease in the United Kingdom (UK) and China. Methods: Development of the Prevention of Dementia by Mobile Phone applications (PRODEMOS) platform built upon the experiences with the Healthy Aging Through Internet Counseling in the Elderly (HATICE) eHealth platform. In the conceptualization phase, experiences from the HATICE trial and needs and wishes of the PRODEMOS target population were assessed through semi-structured interviews and focus group sessions. Initial technical development of the platform was based on these findings and took place in consecutive sprint sessions. Finally, during the evaluation and adaptation phase, functionality and usability of the platform were evaluated during pilot studies in UK and China. Results: The PRODEMOS mHealth platform facilitates self-management of a healthy lifestyle by goal setting, progress monitoring, and educational materials on healthy lifestyles. Participants receive remote coaching through a chat functionality. Based on lessons learned from the HATICE study and end-users, we made the intervention easy-to-use and included features to personalize the intervention. Following the pilot studies, in which in total 77 people used the mobile application for 6 weeks, the application was made more intuitive, and we improved its functionalities. Conclusion: Early involvement of end-users in the development process and during evaluation phases improved acceptability of the mHealth intervention. The actual
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- 2021
28. Prevention of dementia using mobile phone applications (PRODEMOS): Protocol for an international randomised controlled trial
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Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., Richard, Edo, Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., and Richard, Edo
- Abstract
Introduction Profiles of high risk for future dementia are well understood and are likely to concern mostly those in low-income and middle-income countries and people at greater disadvantage in high-income countries. Approximately 30%-40% of dementia cases have been estimated to be attributed to modifiable risk factors, including hypertension, smoking and sedentary lifestyle. Tailored interventions targeting these risk factors can potentially prevent or delay the onset of dementia. Mobile health (mHealth) improves accessibility of such prevention strategies in hard-to-reach populations while at the same time tailoring such approaches. In the current study, we will investigate the effectiveness and implementation of a coach-supported mHealth intervention, targeting dementia risk factors, to reduce dementia risk. Methods and analysis The prevention of dementia using mobile phone applications (PRODEMOS) randomised controlled trial will follow an effectiveness-implementation hybrid design, taking place in the UK and China. People are eligible if they are 55-75 years old, of low socioeconomic status (UK) or from the general population (China); have ≥ 2 dementia risk factors; and own a smartphone. 2400 participants will be randomised to either a coach-supported, interactive mHealth platform, facilitating self-management of dementia risk factors, or a static control platform. The intervention and follow-up period will be 18 months. The primary effectiveness outcome is change in the previously validated Cardiovascular Risk Factors, Ageing and Incidence of Dementia dementia risk score. The main secondary outcomes include improvement of individual risk factors and cost-effectiveness. Implementation outcomes include acceptability, adoption, feasibility and sustainability of the intervention. Ethics and dissemination The PRODEMOS trial is sponsored in the UK by the University of Cambridge and is granted ethical approval by the London - Brighton and Sussex Research Ethics Commit
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- 2021
29. Prevention of dementia using mobile phone applications (PRODEMOS): A randomized controlled trial in progress
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Eggink, Esmé, primary, van Charante, Eric P Moll, additional, Hoevenaar‐Blom, Marieke P, additional, Andrieu, Sandrine, additional, Hafdi, Melanie, additional, Coley, Nicola, additional, Sadhwani, Shan, additional, Wimo, Anders, additional, Barnes, Linda, additional, Handels, Ron, additional, Kivipelto, Miia, additional, Song, Manshu, additional, Georges, Jean, additional, van Der Groep, Bram, additional, van der Meijden, Mark, additional, Wang, Youxin, additional, Wang, Wei, additional, van Gool, Willem A, additional, van Marwijk, Harm, additional, Brayne, Carol, additional, and Richard, Edo, additional
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- 2020
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- View/download PDF
30. Practice variation in diagnosing dementia: A nationwide overview of diagnostic work‐ups in Dutch hospitals
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Hafdi, Melanie, primary, Richard, Edo, additional, and van Gool, Willem A, additional
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- 2020
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31. Multi-domain interventions for the prevention of dementia and cognitive decline
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Hafdi, Melanie, primary, Hoevenaar-Blom, Marieke P., additional, and Richard, Edo, additional
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- 2020
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32. EXPRESS: European Stroke Organisation and European Academy Neurology joint guidelines on post-stroke cognitive impairment
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O’Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Abstract
Introduction: The optimal management of post stroke cognitive impairment remains controversial. These joint European Stroke Organisation (ESO) and European Academy of Neurology (EAN) guidelines provide evidence-based recommendations to assist clinicians in decision making around prevention, diagnosis, treatment, and prognosis. Methods: These guidelines were developed according to ESO standard operating procedure and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. The working group identified relevant clinical questions, performed systematic reviews and, where possible, meta-analyses of the literature, assessed the quality of the available evidence, and made specific recommendations. Expert consensus statements were provided where insufficient evidence was available to provide recommendations based on the GRADE approach. Results: There was limited randomised controlled trial evidence regarding single or multicomponent interventions to prevent post stroke cognitive decline. Interventions to improve lifestyle and treat vascular risk factors may have many health benefits but a beneficial effect on cognition is not proven. We found no evidence around routine cognitive screening following stroke but recognise the importance of targeted cognitive assessment. We described the accuracy of various cognitive screening tests but found no clearly superior approach to testing. There was insufficient evidence to make a recommendation for use of cholinesterase inhibitors, memantine or cognitive rehabilitation for post stroke dementia. We made a weak recommendation against using the nootropics actovegin and cerebrolysin, but quality of evidence was very low. There was limited evidence on the use of prediction tools for post stroke cognitive syndromes (cognitive impairment, dementia and delirium). The association between post stroke cognitive impairment and most acute structural brain imaging features was unclear. Conclusions: These guidelines have highlighted fundamental areas where robust evidence is lacking. Further randomised controlled trials are needed and we suggest priority areas for future research.
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- 2021
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33. European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
- Author
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Quinn, Terence J, Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O'Brien, John T, Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T, Bruffaerts, Rose, Mijajlovic, Milija, Drozdowska, Bogna A, Ball, Emily, and Markus, Hugh S
- Subjects
Cognition ,diagnosis ,guidelines ,prognosis ,stroke ,3. Good health ,dementia - Abstract
The optimal management of post-stroke cognitive impairment remains controversial. These joint European Stroke Organisation (ESO) and European Academy of Neurology (EAN) guidelines provide evidence-based recommendations to assist clinicians in decision making around prevention, diagnosis, treatment and prognosis. These guidelines were developed according to ESO standard operating procedure and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. The working group identified relevant clinical questions, performed systematic reviews and, where possible, meta-analyses of the literature, assessed the quality of the available evidence and made specific recommendations. Expert consensus statements were provided where insufficient evidence was available to provide recommendations based on the GRADE approach. There was limited randomised controlled trial evidence regarding single or multicomponent interventions to prevent post-stroke cognitive decline. Interventions to improve lifestyle and treat vascular risk factors may have many health benefits but a beneficial effect on cognition is not proven. We found no evidence around routine cognitive screening following stroke but recognise the importance of targeted cognitive assessment. We described the accuracy of various cognitive screening tests but found no clearly superior approach to testing. There was insufficient evidence to make a recommendation for use of cholinesterase inhibitors, memantine nootropics or cognitive rehabilitation. There was limited evidence on the use of prediction tools for post-stroke cognitive syndromes (cognitive impairment, dementia and delirium). The association between post-stroke cognitive impairment and most acute structural brain imaging features was unclear, although the presence of substantial white matter hyperintensities of presumed vascular origin on acute MRI brain may help predict cognitive outcomes. These guidelines have highlighted fundamental areas where robust evidence is lacking. Further, definitive randomised controlled trials are needed, and we suggest priority areas for future research.
34. Prevention of dementia using mobile phone applications (PRODEMOS): Protocol for an international randomised controlled trial
- Author
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<p>European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China</p>, Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., Richard, Edo, <p>European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China</p>, Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., and Richard, Edo
- Abstract
Eggink, E., Hafdi, M., Hoevenaar-Blom, M. P., Song, M., Andrieu, S., Barnes, L. E., … Richard, E. (2021). Prevention of dementia using mobile phone applications (PRODEMOS): Protocol for an international randomised controlled trial. BMJ Open, 11(6), article e049762. https://doi.org/10.1136/bmjopen-2021-049762
35. Design and development of a mobile health (mHealth) platform for dementia prevention in the prevention of dementia by mobile phone applications (PRODEMOS) project
- Author
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<p>European Union's Horizon 2020 Research and Innovation Programme</p> <p>National Key R&D Programme of China</p>, Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, PRODEMOS consortium, <p>European Union's Horizon 2020 Research and Innovation Programme</p> <p>National Key R&D Programme of China</p>, Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, and PRODEMOS consortium
- Abstract
Hafdi, M., Eggink, E., Hoevenaar-Blom, M. P., Witvliet, M. P., Andrieu, S., Barnes, L., . . . Richard, E. (2021). Design and development of a mobile health (mHealth) platform for dementia prevention in the prevention of dementia by mobile phone applications (PRODEMOS) project. Frontiers in Neurology, 12, article 733878. https://doi.org/10.3389/fneur.2021.733878
36. European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
- Author
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Rose Bruffaerts, Milija Mijajlovic, Yvonne Teuschl, John T. O'Brien, Terence J. Quinn, Emily L Ball, Hanne Huyglier, Reinhold Schmidt, Bogna A Drozdowska, Celine Gillebert, Hugh S. Markus, Emma Ghaziani, Edo Richard, Melanie Hafdi, Ana Verdelho, Hysse Forchammer, Niamh A. Merriman, Sarah T. Pendlebury, Thomas Gattringer, Neurology, Public and occupational health, 10 Public Health & Methodologie, Graduate School, APH - Health Behaviors & Chronic Diseases, ANS - Neurodegeneration, ANS - Neurovascular Disorders, APH - Mental Health, APH - Methodology, Quinn, Terence J [0000-0003-1401-0181], Teuschl, Yvonne [0000-0002-1755-7943], Bruffaerts, Rose [0000-0002-2631-9234], Drozdowska, Bogna A [0000-0001-5705-7815], Ball, Emily [0000-0002-7445-9581], Apollo - University of Cambridge Repository, Huygelier, Hanne/0000-0002-5177-1193, Quinn, Terence J., Richard, Edo, Teuschl, Yvonne, Gattringer, Thomas, Hafdi, Melanie, O'Brien, John T., Merriman, Niamh, Gillebert, Celine, Huyglier, Hanne, Verdelho, Ana, Schmidt, Reinhold, Ghaziani, Emma, Forchammer, Hysse, Pendlebury, Sarah T., BRUFFAERTS, Rose, Mijajlovic, Milija, Drozdowska, Bogna A., Ball, Emily, and Markus, Hugh S.
- Subjects
cognition ,medicine.medical_specialty ,Neurology ,diagnosis ,law.invention ,03 medical and health sciences ,Physical medicine and rehabilitation ,0302 clinical medicine ,Randomized controlled trial ,law ,Risk Factors ,Medicine ,Dementia ,Humans ,Cognitive Dysfunction ,cardiovascular diseases ,030212 general & internal medicine ,Cognitive rehabilitation therapy ,guidelines ,Cognitive decline ,Cognitive impairment ,Intensive care medicine ,Stroke ,business.industry ,Cognition ,medicine.disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,stroke ,Optimal management ,3. Good health ,Systematic review ,Post stroke ,Delirium ,Neurology (clinical) ,prognosis ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,dementia ,030217 neurology & neurosurgery - Abstract
The optimal management of post-stroke cognitive impairment remains controversial. These joint European Stroke Organisation (ESO) and European Academy of Neurology (EAN) guidelines provide evidence-based recommendations to assist clinicians in decision making around prevention, diagnosis, treatment and prognosis. These guidelines were developed according to ESO standard operating procedure and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. The working group identified relevant clinical questions, performed systematic reviews and, where possible, meta-analyses of the literature, assessed the quality of the available evidence and made specific recommendations. Expert consensus statements were provided where insufficient evidence was available to provide recommendations based on the GRADE approach. There was limited randomised controlled trial evidence regarding single or multicomponent interventions to prevent post-stroke cognitive decline. Interventions to improve lifestyle and treat vascular risk factors may have many health benefits but a beneficial effect on cognition is not proven. We found no evidence around routine cognitive screening following stroke but recognise the importance of targeted cognitive assessment. We described the accuracy of various cognitive screening tests but found no clearly superior approach to testing. There was insufficient evidence to make a recommendation for use of cholinesterase inhibitors, memantine nootropics or cognitive rehabilitation. There was limited evidence on the use of prediction tools for post-stroke cognitive syndromes (cognitive impairment, dementia and delirium). The association between post-stroke cognitive impairment and most acute structural brain imaging features was unclear, although the presence of substantial white matter hyperintensities of presumed vascular origin on acute MRI brain may help predict cognitive outcomes. These guidelines have highlighted fundamental areas where robust evidence is lacking. Further, definitive randomised controlled trials are needed, and we suggest priority areas for future research. ispartof: European Stroke Journal vol:6 issue:3 pages:1-177 ispartof: location:England status: Published online
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- 2021
37. Prevention of dementia using mobile phone applications (PRODEMOS): a multinational, randomised, controlled effectiveness-implementation trial.
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Moll van Charante EP, Hoevenaar-Blom MP, Song M, Andrieu S, Barnes L, Birck C, Brooks R, Coley N, Eggink E, Georges J, Hafdi M, van Gool WA, Handels R, Hou H, Lyu J, Niu Y, Song L, Wang W, Wang Y, Wimo A, Yu Y, Zhang J, Zhang W, Brayne C, Wang W, and Richard E
- Subjects
- Humans, Male, Female, Aged, Middle Aged, China epidemiology, United Kingdom epidemiology, Risk Factors, Dementia prevention & control, Dementia epidemiology, Telemedicine, Mobile Applications
- Abstract
Background: The expected increase of dementia prevalence in the coming decades will mainly be in low-income and middle-income countries and in people with low socioeconomic status in high-income countries. This study aims to reduce dementia risk factors in underserved populations at high-risk using a coach-supported mobile health (mHealth) intervention., Methods: This open-label, blinded endpoint, hybrid effectiveness-implementation randomised controlled trial (RCT) investigated whether a coach-supported mHealth intervention can reduce dementia risk in people aged 55-75 years of low socioeconomic status in the UK or from the general population in China with at least two dementia risk factors. The primary effectiveness outcome was change in cardiovascular risk factors, ageing, and incidence of dementia (CAIDE) risk score from baseline to after 12-18 months of intervention. Implementation outcomes were coverage, adoption, sustainability, appropriateness, acceptability, fidelity, feasibility, and costs assessed using a mixed-methods approach. All participants with complete data on the primary outcome, without imputation of missing outcomes were included in the analysis (intention-to-treat principle). This trial is registered with ISRCTN, ISRCTN15986016, and is completed., Findings: Between Jan 15, 2021, and April 18, 2023, 1488 people (601 male and 887 female) were randomly assigned (734 to intervention and 754 to control), with 1229 (83%) of 1488 available for analysis of the primary effectiveness outcome. After a mean follow-up of 16 months (SD 2·5), the mean CAIDE score improved 0·16 points in the intervention group versus 0·01 in the control group (mean difference -0·16, 95% CI -0·29 to -0·03). 1533 (10%) invited individuals responded; of the intervention participants, 593 (81%) of 734 adopted the intervention and 367 (50%) of 734 continued active participation throughout the study. Perceived appropriateness (85%), acceptability (81%), and fidelity (79%) were good, with fair overall feasibility (53% of intervention participants and 58% of coaches), at low cost. No differences in adverse events between study arms were found., Interpretation: A coach-supported mHealth intervention is modestly effective in reducing dementia risk factors in those with low socioeconomic status in the UK and any socioeconomic status in China. Implementation is challenging in these populations, but those reached actively participated. Whether this intervention will result in less cognitive decline and dementia requires a larger RCT with long follow-up., Funding: EU Horizon 2020 Research and Innovation Programme and the National Key R&D Programmes of China., Translation: For the Mandarin translation of the abstract see Supplementary Materials section., Competing Interests: Declaration of interests AW received research grants from EU IMI2 (MOPEAD), JPND (ADDITION, EURO-FINGER, PMI-AD), IHI (PROMINENT), and the Swedish VINNOVA program (PREDEM)(all paid to institution) and is licence holder of RUD-instrument (in part); outside the submitted work. RH received research grants from JPND, ZonMW, IMI, H2020 (paid to institution); received consulting fees from Lilly Nederland, iMTA, Biogen Nederlands, Biogen MA, Eisai (paid to institution); is a member of ISPOR special interest group open-source models, IPECAD modelling group and Alzheimer Europe Expert Advisory Panel (unpaid); outside the submitted work. SA received grants from EU (Institutional grant [Horizon 2020 Research and Innovation Programme agreement 779238]); Region Occitanie/Pyrénées-Méditerranée (1901175); the European Regional Development Fund (MP0022856); MSD Avenir Inspire Chairs of Excellence (Alzheimer Prevention in Occitania and Catalonia, EDENIS, KORIAN, Pfizer, and Pierre-Fabre); AXA Personal (current); Biogen Personal (2022); Roche Personal (2021); Leventis foundation (2022); ADI (2022); and has a leadership role in the French Alzheimer association (Scientific Committee); outside the submitted work. All other authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
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38. Comparative validity of informant tools for assessing pre-stroke cognitive impairment.
- Author
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Taylor-Rowan M, McGuire L, Hafdi M, Evans J, Stott DJ, Wetherall K, Elliott E, Drozdowska B, and Quinn TJ
- Subjects
- Aged, Humans, Neuropsychological Tests, Sensitivity and Specificity, Surveys and Questionnaires, Cognitive Dysfunction diagnosis, Dementia diagnosis, Frailty, Stroke complications, Stroke diagnosis
- Abstract
Objectives: Various informant-based questionnaires are used in clinical practice to screen for pre-stroke cognitive problems. However, there is no guidance on which tool should be preferred. We compared the validity of the two most commonly used informant-based tools., Methods: We recruited consecutively admitted stroke patients. Patients' informants completed the Informant Questionnaire for Cognitive Decline in the Elderly Short Form (IQCODE-SF, 16-item) and Ascertain Dementia 8 (AD8). We assessed construct validity (accuracy) against a semi-structured clinical interview for dementia or mild cognitive impairment (MCI), describing test accuracy metrics and comparing area under ROC curves (AUROC). We described criterion validity by evaluating associations between test scores and neuroimaging markers of dementia and overall 'brain frailty'. Finally, we described prognostic validity comparing ROC curves for 18-month clinical outcomes of dementia, death, stroke, and disability., Results: One-hundred-thirty-seven patient-informant dyads were recruited. At usual clinical cut-points, the IQCODE-SF had comparable sensitivity to the AD8 (both = 92%) for pre-stroke dementia, but superior specificity (IQCODE-SF: 82% vs. AD8: 58%). Youden index suggested that the optimal AD8 threshold for diagnosis of dementia is ≥4. The IQCODE-SF demonstrated stronger associations with markers of generalised and medial-temporal lobe atrophy, neurovascular disease, and overall brain frailty. IQCODE-SF also demonstrated greater accuracy for predicting future dementia (IQCODE-SF AUROC = 0.903, 95% CI = 0.798-1.00; AD8 AUROC = 0.821, 95% CI = 0.664-0.977)., Conclusions: Both IQCODE-SF and AD8 are valid measures of pre-stroke dementia. Higher cut points for AD8 may improve performance in the acute stroke setting. Based on consistent superiority across a range of validity analyses, IQCODE-SF may be preferable to AD8 for pre-stroke dementia screening., (© 2022 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.)
- Published
- 2022
- Full Text
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