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202 results on '"Haegert, Anne"'

2. Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma

Author

Wong, Nelson K.Y., Llaurado Fernandez, Marta, Kommoss, Felix K.F., Praveen Kumar, Pooja, Kim, Hannah, Liu, Jiahui, Zhang, Guihua, Coatham, Mackenzie, Lin, Yen-Yi, Haegert, Anne M., Volik, Stanislav, Le Bihan, Stephane, Collins, Colin C., Fu, Yangxin, Postovit, Lynne M., von Deimling, Andreas, Wu, Rebecca, Xue, Hui, Wang, Yuzhuo, Köbel, Martin, Carey, Mark S., and Lee, Cheng-Han

Published
2023
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3. Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma

Author

Shrestha, Raunak, Nabavi, Noushin, Volik, Stanislav, Anderson, Shawn, Haegert, Anne, McConeghy, Brian, Sar, Funda, Brahmbhatt, Sonal, Bell, Robert, Le Bihan, Stephane, Wang, Yuzhuo, Collins, Colin, and Churg, Andrew

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Cancer, well-differentiated papillary mesothelioma, WDPM, malignant mesothelioma, DNA sequencing, mutation, Oncology and carcinogenesis
Abstract

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations in EHD1, ATM, FBXO10, SH2D2A, CDH5, MAGED1, and TP73 shared by WDPM cases but not reported in malignant mesotheliomas. Furthermore, we show that WDPM is strongly enriched with C > A transversion substitution mutations, a pattern that is also not found in malignant mesotheliomas. The WDPMs lacked the alterations involving BAP1, SETD2, NF2, CDKN2A/B, LASTS1/2, PBRM1, and SMARCC1 that are frequently found in malignant mesotheliomas. We conclude that WDPMs are neoplasms that are genetically distinct from malignant mesotheliomas and, based on observed mutations, do not appear to be precursors of malignant mesotheliomas.

Published
2020

5. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis

Author

Shi, Feng-Tao, Yu, Mei, Zloty, David, Bell, Robert H, Wang, Eddy, Akhoundsadegh, Noushin, Leung, Gigi, Haegert, Anne, Carr, Nicholas, Shapiro, Jerry, and McElwee, Kevin J

Subjects
Medicinal and Biomolecular Chemistry, Chemical Sciences, Aetiology, 2.1 Biological and endogenous factors, Apoptosis, Carcinoma, Basal Cell, Cluster Analysis, Fas Ligand Protein, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Ontology, Gene Regulatory Networks, Hair Follicle, Humans, Jagged-1 Protein, Oligonucleotide Array Sequence Analysis, Receptors, Notch, Reproducibility of Results, Signal Transduction, Skin Neoplasms, Biochemistry and Cell Biology, Oncology & Carcinogenesis, Medicinal and biomolecular chemistry
Abstract

A subset of basal cell carcinomas (BCCs) are directly derived from hair follicles (HFs). In some respects, HFs can be defined as 'ordered' skin appendage growths, while BCCs can be regarded as 'disordered' skin appendage growths. The aim of the present study was to examine HFs and BCCs to define the expression of common and unique signaling pathways in each skin appendage. Human nodular BCCs, along with HFs and non‑follicular skin epithelium from normal individuals, were examined using microarrays, qPCR, and immunohistochemistry. Subsequently, BCC cells and root sheath keratinocyte cells from HFs were cultured and treated with Notch signaling peptide Jagged1 (JAG1). Gene expression, protein levels, and cell apoptosis susceptibility were assessed using qPCR, immunoblotting, and flow cytometry, respectively. Specific molecular mechanisms were found to be involved in the process of cell self‑renewal in the HFs and BCCs, including Notch and Hedgehog signaling pathways. However, several key Notch signaling factors showed significant differential expression in BCCs compared with HFs. Stimulating Notch signaling with JAG1 induced apoptosis of BCC cells by increasing Fas ligand expression and downstream caspase-8 activation. The present study showed that Notch signaling pathway activity is suppressed in BCCs, and is highly expressed in HFs. Elements of the Notch pathway could, therefore, represent targets for the treatment of BCCs and potentially in hair follicle engineering.

Published
2017

7. Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer

Author

Hao, Jun, Ci, Xinpei, Xue, Hui, Wu, Rebecca, Dong, Xin, Choi, Stephen Yiu Chuen, He, Haiqing, Wang, Yu, Zhang, Fang, Qu, Sifeng, Zhang, Fan, Haegert, Anne M., Gout, Peter W., Zoubeidi, Amina, Collins, Colin, Gleave, Martin E., Lin, Dong, and Wang, Yuzhuo

Published
2018
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8. Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

Author

Mo, Fan, Lin, Dong, Takhar, Mandeep, Ramnarine, Varune Rohan, Dong, Xin, Bell, Robert H., Volik, Stanislav V., Wang, Kendric, Xue, Hui, Wang, Yuwei, Haegert, Anne, Anderson, Shawn, Brahmbhatt, Sonal, Erho, Nicholas, Wang, Xinya, Gout, Peter W., Morris, James, Karnes, R. Jeffrey, Den, Robert B., Klein, Eric A., Schaeffer, Edward M., Ross, Ashley, Ren, Shancheng, Sahinalp, S. Cenk, Li, Yingrui, Xu, Xun, Wang, Jun, Wang, Jian, Gleave, Martin E., Davicioni, Elai, Sun, Yinghao, Wang, Yuzhuo, and Collins, Colin C.

Published
2018
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9. Supplementary Figure 1 from Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target

Author

Collins, Colin C., primary, Volik, Stanislav V., primary, Lapuk, Anna V., primary, Wang, Yuwei, primary, Gout, Peter W., primary, Wu, Chunxiao, primary, Xue, Hui, primary, Cheng, Hongwei, primary, Haegert, Anne, primary, Bell, Robert H., primary, Brahmbhatt, Sonal, primary, Anderson, Shawn, primary, Fazli, Ladan, primary, Hurtado-Coll, Antonio, primary, Rubin, Mark A., primary, Demichelis, Francesca, primary, Beltran, Himisha, primary, Hirst, Martin, primary, Marra, Marco, primary, Maher, Christopher A., primary, Chinnaiyan, Arul M., primary, Gleave, Martin, primary, Bertino, Joseph R., primary, Lubin, Martin, primary, and Wang, Yuzhuo, primary

Published
2023
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10. Data from Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications

Author

Dong, Xin, primary, Xue, Hui, primary, Mo, Fan, primary, Lin, Yen-yi, primary, Lin, Dong, primary, Wong, Nelson K.Y., primary, Sun, Yingqiang, primary, Wilkinson, Scott, primary, Ku, Anson T., primary, Hao, Jun, primary, Ci, Xinpei, primary, Wu, Rebecca, primary, Haegert, Anne, primary, Silver, Rebecca, primary, Taplin, Mary-Ellen, primary, Balk, Steven P., primary, Alumkal, Joshi J., primary, Sowalsky, Adam G., primary, Gleave, Martin, primary, Collins, Colin, primary, and Wang, Yuzhuo, primary

Published
2023
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11. Data from Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target

Author

Collins, Colin C., primary, Volik, Stanislav V., primary, Lapuk, Anna V., primary, Wang, Yuwei, primary, Gout, Peter W., primary, Wu, Chunxiao, primary, Xue, Hui, primary, Cheng, Hongwei, primary, Haegert, Anne, primary, Bell, Robert H., primary, Brahmbhatt, Sonal, primary, Anderson, Shawn, primary, Fazli, Ladan, primary, Hurtado-Coll, Antonio, primary, Rubin, Mark A., primary, Demichelis, Francesca, primary, Beltran, Himisha, primary, Hirst, Martin, primary, Marra, Marco, primary, Maher, Christopher A., primary, Chinnaiyan, Arul M., primary, Gleave, Martin, primary, Bertino, Joseph R., primary, Lubin, Martin, primary, and Wang, Yuzhuo, primary

Published
2023
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12. Supplementary Data from Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications

Author

Dong, Xin, primary, Xue, Hui, primary, Mo, Fan, primary, Lin, Yen-yi, primary, Lin, Dong, primary, Wong, Nelson K.Y., primary, Sun, Yingqiang, primary, Wilkinson, Scott, primary, Ku, Anson T., primary, Hao, Jun, primary, Ci, Xinpei, primary, Wu, Rebecca, primary, Haegert, Anne, primary, Silver, Rebecca, primary, Taplin, Mary-Ellen, primary, Balk, Steven P., primary, Alumkal, Joshi J., primary, Sowalsky, Adam G., primary, Gleave, Martin, primary, Collins, Colin, primary, and Wang, Yuzhuo, primary

Published
2023
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13. Supplementary Table 5 from Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Author

Azad, Arun A., primary, Volik, Stanislav V., primary, Wyatt, Alexander W., primary, Haegert, Anne, primary, Le Bihan, Stephane, primary, Bell, Robert H., primary, Anderson, Shawn A., primary, McConeghy, Brian, primary, Shukin, Robert, primary, Bazov, Jenny, primary, Youngren, Jack, primary, Paris, Pamela, primary, Thomas, George, primary, Small, Eric J., primary, Wang, Yuzhuo, primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Chi, Kim N., primary

Published
2023
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14. Supplementary Table S1 from BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Author

Luk, Iris Sze Ue, primary, Shrestha, Raunak, primary, Xue, Hui, primary, Wang, Yuwei, primary, Zhang, Fang, primary, Lin, Dong, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Dong, Xin, primary, Collins, Colin C., primary, Zoubeidi, Amina, primary, Gleave, Martin E., primary, Gout, Peter W., primary, and Wang, Yuzhuo, primary

Published
2023
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15. Supplementary figure S2 from BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Author

Luk, Iris Sze Ue, primary, Shrestha, Raunak, primary, Xue, Hui, primary, Wang, Yuwei, primary, Zhang, Fang, primary, Lin, Dong, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Dong, Xin, primary, Collins, Colin C., primary, Zoubeidi, Amina, primary, Gleave, Martin E., primary, Gout, Peter W., primary, and Wang, Yuzhuo, primary

Published
2023
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16. Supplementary Figure 1 from Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Author

Azad, Arun A., primary, Volik, Stanislav V., primary, Wyatt, Alexander W., primary, Haegert, Anne, primary, Le Bihan, Stephane, primary, Bell, Robert H., primary, Anderson, Shawn A., primary, McConeghy, Brian, primary, Shukin, Robert, primary, Bazov, Jenny, primary, Youngren, Jack, primary, Paris, Pamela, primary, Thomas, George, primary, Small, Eric J., primary, Wang, Yuzhuo, primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Chi, Kim N., primary

Published
2023
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17. Supplementary Data from Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability

Author

Shrestha, Raunak, primary, Llaurado Fernandez, Marta, primary, Dawson, Amy, primary, Hoenisch, Joshua, primary, Volik, Stanislav, primary, Lin, Yen-Yi, primary, Anderson, Shawn, primary, Kim, Hannah, primary, Haegert, Anne M., primary, Colborne, Shane, primary, Wong, Nelson K.Y., primary, McConeghy, Brian, primary, Bell, Robert H., primary, Brahmbhatt, Sonal, primary, Lee, Cheng-Han, primary, DiMattia, Gabriel E., primary, Le Bihan, Stephane, primary, Morin, Gregg B., primary, Collins, Colin C., primary, and Carey, Mark S., primary

Published
2023
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18. Supplementary Table 2 from Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Author

Azad, Arun A., primary, Volik, Stanislav V., primary, Wyatt, Alexander W., primary, Haegert, Anne, primary, Le Bihan, Stephane, primary, Bell, Robert H., primary, Anderson, Shawn A., primary, McConeghy, Brian, primary, Shukin, Robert, primary, Bazov, Jenny, primary, Youngren, Jack, primary, Paris, Pamela, primary, Thomas, George, primary, Small, Eric J., primary, Wang, Yuzhuo, primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Chi, Kim N., primary

Published
2023
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19. Data from Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer

Author

Ci, Xinpei, primary, Hao, Jun, primary, Dong, Xin, primary, Choi, Stephen Y., primary, Xue, Hui, primary, Wu, Rebecca, primary, Qu, Sifeng, primary, Gout, Peter W., primary, Zhang, Fang, primary, Haegert, Anne M., primary, Fazli, Ladan, primary, Crea, Francesco, primary, Ong, Christopher J., primary, Zoubeidi, Amina, primary, He, Housheng H., primary, Gleave, Martin E., primary, Collins, Colin C., primary, Lin, Dong, primary, and Wang, Yuzhuo, primary

Published
2023
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20. Supplementary Information from Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer

Author

Ci, Xinpei, primary, Hao, Jun, primary, Dong, Xin, primary, Choi, Stephen Y., primary, Xue, Hui, primary, Wu, Rebecca, primary, Qu, Sifeng, primary, Gout, Peter W., primary, Zhang, Fang, primary, Haegert, Anne M., primary, Fazli, Ladan, primary, Crea, Francesco, primary, Ong, Christopher J., primary, Zoubeidi, Amina, primary, He, Housheng H., primary, Gleave, Martin E., primary, Collins, Colin C., primary, Lin, Dong, primary, and Wang, Yuzhuo, primary

Published
2023
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21. Supplementary Table 1 from Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Author

Azad, Arun A., primary, Volik, Stanislav V., primary, Wyatt, Alexander W., primary, Haegert, Anne, primary, Le Bihan, Stephane, primary, Bell, Robert H., primary, Anderson, Shawn A., primary, McConeghy, Brian, primary, Shukin, Robert, primary, Bazov, Jenny, primary, Youngren, Jack, primary, Paris, Pamela, primary, Thomas, George, primary, Small, Eric J., primary, Wang, Yuzhuo, primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Chi, Kim N., primary

Published
2023
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22. Supplementary figure legends from BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Author

Luk, Iris Sze Ue, primary, Shrestha, Raunak, primary, Xue, Hui, primary, Wang, Yuwei, primary, Zhang, Fang, primary, Lin, Dong, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Dong, Xin, primary, Collins, Colin C., primary, Zoubeidi, Amina, primary, Gleave, Martin E., primary, Gout, Peter W., primary, and Wang, Yuzhuo, primary

Published
2023
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23. Supplementary Table 3 from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., primary, Xue, Hui, primary, Wang, Yuwei, primary, Dong, Xin, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Brahmbhatt, Sonal, primary, Mo, Fan, primary, Jong, Lina, primary, Bell, Robert H., primary, Anderson, Shawn, primary, Hurtado-Coll, Antonio, primary, Fazli, Ladan, primary, Sharma, Manju, primary, Beltran, Himisha, primary, Rubin, Mark, primary, Cox, Michael, primary, Gout, Peter W., primary, Morris, James, primary, Goldenberg, Larry, primary, Volik, Stanislav V., primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Wang, Yuzhuo, primary

Published
2023
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24. Supplementary Figures 1 - 9 from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., primary, Xue, Hui, primary, Wang, Yuwei, primary, Dong, Xin, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Brahmbhatt, Sonal, primary, Mo, Fan, primary, Jong, Lina, primary, Bell, Robert H., primary, Anderson, Shawn, primary, Hurtado-Coll, Antonio, primary, Fazli, Ladan, primary, Sharma, Manju, primary, Beltran, Himisha, primary, Rubin, Mark, primary, Cox, Michael, primary, Gout, Peter W., primary, Morris, James, primary, Goldenberg, Larry, primary, Volik, Stanislav V., primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Wang, Yuzhuo, primary

Published
2023
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25. Data from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., primary, Xue, Hui, primary, Wang, Yuwei, primary, Dong, Xin, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Brahmbhatt, Sonal, primary, Mo, Fan, primary, Jong, Lina, primary, Bell, Robert H., primary, Anderson, Shawn, primary, Hurtado-Coll, Antonio, primary, Fazli, Ladan, primary, Sharma, Manju, primary, Beltran, Himisha, primary, Rubin, Mark, primary, Cox, Michael, primary, Gout, Peter W., primary, Morris, James, primary, Goldenberg, Larry, primary, Volik, Stanislav V., primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Wang, Yuzhuo, primary

Published
2023
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26. Supplementary Table 1 from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., primary, Xue, Hui, primary, Wang, Yuwei, primary, Dong, Xin, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Brahmbhatt, Sonal, primary, Mo, Fan, primary, Jong, Lina, primary, Bell, Robert H., primary, Anderson, Shawn, primary, Hurtado-Coll, Antonio, primary, Fazli, Ladan, primary, Sharma, Manju, primary, Beltran, Himisha, primary, Rubin, Mark, primary, Cox, Michael, primary, Gout, Peter W., primary, Morris, James, primary, Goldenberg, Larry, primary, Volik, Stanislav V., primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Wang, Yuzhuo, primary

Published
2023
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27. Supplementary Table 2 from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., primary, Xue, Hui, primary, Wang, Yuwei, primary, Dong, Xin, primary, Haegert, Anne, primary, Wu, Rebecca, primary, Brahmbhatt, Sonal, primary, Mo, Fan, primary, Jong, Lina, primary, Bell, Robert H., primary, Anderson, Shawn, primary, Hurtado-Coll, Antonio, primary, Fazli, Ladan, primary, Sharma, Manju, primary, Beltran, Himisha, primary, Rubin, Mark, primary, Cox, Michael, primary, Gout, Peter W., primary, Morris, James, primary, Goldenberg, Larry, primary, Volik, Stanislav V., primary, Gleave, Martin E., primary, Collins, Colin C., primary, and Wang, Yuzhuo, primary

Published
2023
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29. Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

Author

Huang, Kate, primary, Ashraf, Mishal, additional, Rohani, Leili, additional, Luo, Yinhan, additional, Sacayanan, Ardin, additional, Huang, Haojun, additional, Haegert, Anne, additional, Volik, Stanislav, additional, Sar, Funda, additional, LeBihan, Stéphane, additional, Liew, Janet, additional, Roberts, Jason D., additional, Tibbits, Glen F., additional, Churko, Jared M., additional, Sanatani, Shubhayan, additional, Collins, Colin, additional, Brunham, Liam R., additional, and Laksman, Zachary W., additional

Published
2023
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33. Indwelling stents cause obstruction and induce ureteral injury and fibrosis in a porcine model.

Author

Scotland, Kymora B., Almutairi, Khaled, Park, Elliya, Wang, Lu, Kung, Sonia H.Y., Haegert, Anne, Adomat, Hans, Bell, Robert, LeBihan, Stephane, Chew, Ben H., and Lange, Dirk

Subjects
URETERIC obstruction, RENAL fibrosis, FIBROSIS, KIDNEY injuries, WOUNDS & injuries
Abstract

Objectives: To investigate global changes in ureters at the transcriptional, translational and functional levels, both while stents are indwelling and after removal and recovery, and to study the effects of targeting pathways that play a potential role. Methods: Pig ureters were stented for varying amounts of time (48 h, 72 h, 14 days) and the impact on peristalsis, dilatation and hydronephrosis were assessed. RNAseq, proteomic, histological and smooth muscle (SM) function analyses were performed on ureteric and kidney tissues to assess changes induced by stenting and recovery. Pathway analysis was performed using Ingenuity Pathway Analysis software. To study the impact of possible interventions, the effects of erythropoeitin (EPO) and a Gli1 inhibitor were assessed. Results: Stenting triggers massive ureteric dilatation, aperistalsis and moderate hydronephrosis within 48 h. Pathways associated with obstruction, fibrosis and kidney injury were upregulated by stenting. Increased expression of GLI1, clusterin‐α (a kidney injury marker) and collagen 4A2 (a fibrosis marker) was found in stented vs contralateral unstented ureters. EPO did not improve peristalsis or contraction force but did decrease non‐purposeful spasming seen exclusively in stented ureters. Tamsulosin administration increased contractility but not rate of peristalsis in stented ureters. Conclusions: Ureters respond to stents similarly to how they respond to an obstruction, that is, with activation of pathways associated with hydronephrosis, fibrosis and kidney injury. This is driven by significant dilatation and associated ureteric SM dysfunction. EPO and tamsulosin induced mild favourable changes in SM physiology, suggesting that targeting specific pathways has potential to address stent‐induced complications. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications

Author

Dong, Xin, primary, Xue, Hui, additional, Mo, Fan, additional, Lin, Yen-yi, additional, Lin, Dong, additional, Wong, Nelson K.Y., additional, Sun, Yingqiang, additional, Wilkinson, Scott, additional, Ku, Anson T., additional, Hao, Jun, additional, Ci, Xinpei, additional, Wu, Rebecca, additional, Haegert, Anne, additional, Silver, Rebecca, additional, Taplin, Mary-Ellen, additional, Balk, Steven P., additional, Alumkal, Joshi J., additional, Sowalsky, Adam G., additional, Gleave, Martin, additional, Collins, Colin, additional, and Wang, Yuzhuo, additional

Published
2022
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37. Novel lignin-capped silver nanoparticles against multidrug resistant bacteria

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Slavin, Yael N., Ivanova, Kristina Dimitrova, Hoyo Pérez, Javier, Perelshtein, Ilana, Owen, Gethin, Haegert, Anne, Lin, Yen-Yi, LeBihan, Stephane, Gedanken, Aharon, Häfeli, Urs O., Tzanov, Tzanko, Bach, Horacio, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Slavin, Yael N., Ivanova, Kristina Dimitrova, Hoyo Pérez, Javier, Perelshtein, Ilana, Owen, Gethin, Haegert, Anne, Lin, Yen-Yi, LeBihan, Stephane, Gedanken, Aharon, Häfeli, Urs O., Tzanov, Tzanko, and Bach, Horacio

Abstract

The emergence of bacteria resistant to antibiotics and the resulting infections are increasingly becoming a public health issue. Multidrug-resistant (MDR) bacteria are responsible for infections leading to increased morbidity and mortality in hospitals, prolonged time of hospitalization, and additional burden to financial costs. Therefore, there is an urgent need for novel antibacterial agents that will both treat MDR infections and outsmart the bacterial evolutionary mechanisms, preventing further resistance development. In this study, a green synthesis employing nontoxic lignin as both reducing and capping agents was adopted to formulate stable and biocompatible silver–lignin nanoparticles (NPs) exhibiting antibacterial activity. The resulting silver–lignin NPs were approximately 20 nm in diameter and did not agglomerate after one year of storage at 4 °C. They were able to inhibit the growth of a panel of MDR clinical isolates, including Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii, at concentrations that did not affect the viability of a monocyte-derived THP-1 human cell line. Furthermore, the exposure of silver–lignin NPs to the THP-1 cells led to a significant increase in the secretion of the anti-inflammatory cytokine IL-10, demonstrating the potential of these particles to act as an antimicrobial and anti-inflammatory agent simultaneously. P. aeruginosa genes linked with efflux, heavy metal resistance, capsular biosynthesis, and quorum sensing were investigated for changes in gene expression upon sublethal exposure to the silver–lignin NPs. Genes encoding for membrane proteins with an efflux function were upregulated. However, all other genes were membrane proteins that did not efflux metals and were downregulated., Peer Reviewed, Postprint (published version)

Published
2021

38. Novel Lignin-Capped Silver Nanoparticles against Multidrug-Resistant Bacteria

Author

Slavin, Yael N., primary, Ivanova, Kristina, additional, Hoyo, Javier, additional, Perelshtein, Ilana, additional, Owen, Gethin, additional, Haegert, Anne, additional, Lin, Yen-Yi, additional, LeBihan, Stephane, additional, Gedanken, Aharon, additional, Häfeli, Urs O., additional, Tzanov, Tzanko, additional, and Bach, Horacio, additional

Published
2021
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39. From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

Author

Lapuk, Anna V, Wu, Chunxiao, Wyatt, Alexander W, McPherson, Andrew, McConeghy, Brian J, Brahmbhatt, Sonal, Mo, Fan, Zoubeidi, Amina, Anderson, Shawn, Bell, Robert H, Haegert, Anne, Shukin, Robert, Wang, Yuzhuo, Fazli, Ladan, Hurtado-Coll, Antonio, Jones, Edward C, Hach, Faraz, Hormozdiari, Fereydoun, Hajirasouliha, Iman, Boutros, Paul C, Bristow, Robert G, Zhao, Yongjun, Marra, Marco A, Fanjul, Andrea, Maher, Christopher A, Chinnaiyan, Arul M, Rubin, Mark A, Beltran, Himisha, Sahinalp, S Cenk, Gleave, Martin E, Volik, Stanislav V, and Collins, Colin C

Published
2012
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40. Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer

Author

Wu, Chunxiao, Wyatt, Alexander W, Lapuk, Anna V, McPherson, Andrew, McConeghy, Brian J, Bell, Robert H, Anderson, Shawn, Haegert, Anne, Brahmbhatt, Sonal, Shukin, Robert, Mo, Fan, Li, Estelle, Fazli, Ladan, Hurtado-Coll, Antonio, Jones, Edward C, Butterfield, Yaron S, Hach, Faraz, Hormozdiari, Fereydoun, Hajirasouliha, Iman, Boutros, Paul C, Bristow, Robert G, Jones, Steven JM, Hirst, Martin, Marra, Marco A, Maher, Christopher A, Chinnaiyan, Arul M, Sahinalp, S Cenk, Gleave, Martin E, Volik, Stanislav V, and Collins, Colin C

Published
2012
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41. Perivascular lymphocytic aggregates in hip prosthesis‐associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8 + cell responses

Author

Eltit, Felipe, primary, Mohammad, Nissreen, additional, Medina, Indira, additional, Haegert, Anne, additional, Duncan, Clive P., additional, Garbuz, Donald S., additional, Greidanus, Nelson V., additional, Masri, Bassam A., additional, Ng, Tony L., additional, Wang, Rizhi, additional, and Cox, Michael E., additional

Published
2021
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42. Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability

Author

Shrestha, Raunak, primary, Llaurado Fernandez, Marta, additional, Dawson, Amy, additional, Hoenisch, Joshua, additional, Volik, Stanislav, additional, Lin, Yen-Yi, additional, Anderson, Shawn, additional, Kim, Hannah, additional, Haegert, Anne M., additional, Colborne, Shane, additional, Wong, Nelson K.Y., additional, McConeghy, Brian, additional, Bell, Robert H., additional, Brahmbhatt, Sonal, additional, Lee, Cheng-Han, additional, DiMattia, Gabriel E., additional, Le Bihan, Stephane, additional, Morin, Gregg B., additional, Collins, Colin C., additional, and Carey, Mark S., additional

Published
2021
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44. Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma

Author

Shrestha, Raunak, primary, Fernandez, Marta Llaurado, additional, Dawson, Amy, additional, Hoenisch, Joshua, additional, Volik, Stanislav, additional, Lin, Yen-Yi, additional, Anderson, Shawn, additional, Kim, Hannah, additional, Haegert, Anne, additional, Colborne, Shane, additional, McConeghy, Brian, additional, Bell, Robert H., additional, Brahmbhatt, Sonal, additional, DiMattia, Gabriel E., additional, Le Bihan, Stephane, additional, Morin, Gregg B., additional, Collins, Colin C., additional, and Carey, Mark S., additional

Published
2020
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46. Germline CDH1 deletions in hereditary diffuse gastric cancer families

Author

Oliveira, Carla, Senz, Janine, Kaurah, Pardeep, Pinheiro, Hugo, Sanges, Remo, Haegert, Anne, Corso, Giovanni, Schouten, Jan, Fitzgerald, Rebecca, Vogelsang, Holger, Keller, Gisela, Dwerryhouse, Sarah, Grimmer, Donna, Chin, Suet-Feung, Yang, Han-Kwang, Jackson, Charles E., Seruca, Raquel, Roviello, Franco, Stupka, Elia, Caldas, Carlos, and Huntsman, David

Published
2009

47. Perivascular lymphocytic aggregates in hip prosthesis‐associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8+ cell responses.

Author

Eltit, Felipe, Mohammad, Nissreen, Medina, Indira, Haegert, Anne, Duncan, Clive P., Garbuz, Donald S., Greidanus, Nelson V., Masri, Bassam A., Ng, Tony L., Wang, Rizhi, and Cox, Michael E.

Subjects
MACROPHAGE inflammatory proteins, SYNOVIAL fluid, T cells, INTERLEUKIN-1 receptors, T helper cells, OSTEOARTHRITIS, JOINT infections
Abstract

Hip implants are a successful solution for osteoarthritis; however, some individuals with metal‐on‐metal (MoM) and metal‐on‐polyethylene (MoP) prosthetics develop adverse local tissue reactions (ALTRs). While MoM and MoP ALTRs are presumed to be delayed hypersensitivity reactions to corrosion products, MoM‐ and MoP‐associated ALTRs present with different histological characteristics. We compared MoM‐ and MoP‐associated ALTRs histopathology with cobalt and chromium levels in serum and synovial fluid. We analyzed the gene expression levels of leukocyte aggregates and synovial fluid chemokines/cytokines to resolve potential pathophysiologic differences. In addition, we classified ALTRs from 79 patients according to their leukocyte infiltrates as macrophage‐dominant, mixed, and lymphocyte‐dominant. Immune‐related transcript profiles from lymphocyte‐dominant MoM‐ and MoP‐associated ALTR patients with perivascular lymphocytic aggregates were similar. Cell signatures indicated predominantly macrophage, Th1 and Th2 lymphocytic infiltrate, with strong exhausted CD8+ signature, and low Th17 and B cell, relative to healthy lymph nodes. Lymphocyte‐dominant ALTR‐associated synovial fluid contained higher levels of induced protein 10 (IP‐10), interleukin‐1 receptor antagonist (IL‐1RN), IL‐8, IL‐6, IL‐16, macrophage inflammatory protein 1 (MIP‐1α), IL‐18, MCP‐2, and lower cell‐attracting chemokine levels, when compared with prosthetic revisions lacking ALTRs. In addition, the higher levels of IP‐10, IL‐8, IL‐6, MIP‐1α, and MCP‐2 were observed within the synovial fluid of the lymphocyte‐dominant ALTRs relative to the macrophage‐dominant ALTRs. Not all cytokines/chemokines were detected in the perivascular aggregate transcripts, suggesting the existence of other sources in the affected synovia. Our results support the hypothesis of common hypersensitivity pathogenesis in lymphocyte‐dominant MoM and MoP ALTRs. The exhausted lymphocyte signature indicates chronic processes and an impaired immune response, although the cause of the persistent T‐cell activation remains unclear. The cytokine/chemokine signature of lymphocyte‐dominant‐associated ATLRs may be of utility for diagnosing this more aggressive pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Additional file 1: of BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

Author

Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Mo, Fan, Anderson, Shawn, Volik, Stanislav, Adomat, Hans, Lin, Dong, Xue, Hui, Dong, Xin, Shukin, Robert, Bell, Robert, McConeghy, Brian, Haegert, Anne, Brahmbhatt, Sonal, Li, Estelle, Htoo Oo, Hurtado-Coll, Antonio, Fazli, Ladan, Zhou, Joshua, Yarrow McConnell, McCart, Andrea, Lowy, Andrew, Morin, Gregg, Tianhui Chen, Daugaard, Mads, S. Sahinalp, Faraz Hach, Stephane Bihan, Gleave, Martin, Yuzhuo Wang, Churg, Andrew, and Collins, Colin

Abstract

Supplementary material. (PDF 11113 kb)

Published
2019
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