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1. Long-term outcomes with biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomised superiority trial

Author

Iglesias, Juan F, Roffi, Marco, Losdat, Sylvain, Muller, Olivier, Degrauwe, Sophie, Kurz, David J, Haegeli, Laurent, Weilenmann, Daniel, Kaiser, Christoph, Tapponnier, Maxime, Cook, Stéphane, Cuculi, Florim, Heg, Dik, Windecker, Stephan, and Pilgrim, Thomas

Published
2023
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2. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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6. Usefulness of Electrocardiographic Parameters for Risk Prediction in Arrhythmogenic Right Ventricular Dysplasia

Author

Saguner, Ardan M., Ganahl, Sabrina, Baldinger, Samuel H., Kraus, Andrea, Medeiros-Domingo, Argelia, Nordbeck, Sebastian, Saguner, Arhan R., Mueller-Burri, Andreas S., Haegeli, Laurent M., Wolber, Thomas, Steffel, Jan, Krasniqi, Nazmi, Delacrétaz, Etienne, Lüscher, Thomas F., Held, Leonhard, Brunckhorst, Corinna B., and Duru, Firat

Published
2014
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7. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Author

Rao, Sunil V., primary, Kirsch, Bodo, additional, Bhatt, Deepak L., additional, Budaj, Andrzej, additional, Coppolecchia, Rosa, additional, Eikelboom, John, additional, James, Stefan K., additional, Jones, W. Schuyler, additional, Merkely, Bela, additional, Keller, Lars, additional, Hermanides, Renicus S., additional, Campo, Gianluca, additional, Ferreiro, José Luis, additional, Shibasaki, Taro, additional, Mundl, Hardi, additional, Alexander, John H., additional, Hengstenberg, Christian, additional, Steinwender, Clemens, additional, Alber, Hannes, additional, Steringer-Mascherbauer, Regina, additional, Schober, Andreas, additional, Auer, Johann, additional, Roithinger, Franz Xaver, additional, von Lewinski, Dirk, additional, Moertl, Deddo, additional, Huber, Kurt, additional, Coussement, Patrick, additional, Hoffer, Etienne, additional, Beauloye, Christophe, additional, Janssens, Luc, additional, Vranckx, Pascal, additional, De Raedt, Herbert, additional, Vanassche, Thomas, additional, Vrolix, Matthias, additional, Rokyta, Richard, additional, Parenica, Jiri, additional, Pelouch, Radek, additional, Motovska, Zuzanna, additional, Alan, David, additional, Kettner, Jiri, additional, Polasek, Rostislav, additional, Cermak, Ondrej, additional, Sedlon, Pavel, additional, Hanis, Jiri, additional, Novak, Martin, additional, Belohlavek, Jan, additional, Horacek, Thomas, additional, Leggewie, Stefan, additional, Wenzel, Philip, additional, vom Dahl, Juergen, additional, Sievers, Burkhard, additional, Pulz, Jan, additional, Schellong, Sebastian, additional, Clemmensen, Peter, additional, Muller-Hennessen, Matthias, additional, Rassaf, Tienush, additional, Falukozi, Jozsef, additional, Ruzsa, Zoltan, additional, Tomcsanyi, Janos, additional, Csanadi, Zoltan, additional, Herczeg, Bela, additional, Koszegi, Zsolt, additional, Vorobcsuk, Andras, additional, Kiss, Robert, additional, Baranyai, Csaba, additional, Dezsi, Csaba, additional, Lupkovics, Geza, additional, Rossini, Roberta, additional, Scherillo, Marino, additional, Sergio Saba, Pier, additional, Calogero Campo, Gianluca, additional, Calo, Leonardo, additional, Nassiacos, Daniele, additional, Quadri, Giorgio, additional, Sciahbasi, Alessandro, additional, Silvio Marenzi, Gian Carlo, additional, Reimers, Bernhard, additional, Perna, Gian Piero, additional, Sacca, Salvatore, additional, Fattore, Luciano, additional, Brunelli, Claudio, additional, Picchi, Andrea, additional, Kuramochi, Takehiko, additional, Kondo, Kazuhisa, additional, Aoyama, Takahiko, additional, Kudoh, Takashi, additional, Yamamoto, Tadashi, additional, Takaya, Tomofumi, additional, Mukai, Yasushi, additional, Fukui, Kazuki, additional, Morioka, Nobuyuki, additional, Ando, Kenji, additional, Yamamuro, Atsushi, additional, Morita, Yasuhiro, additional, Koga, Yasuaki, additional, Watanabe, Tetsuya, additional, Sakamoto, Tomohiro, additional, Maebuchi, Daisuke, additional, Takahashi, Akihiko, additional, Yonetsu, Taishi, additional, Kakuta, Tsunekazu, additional, Nishina, Hidetaka, additional, Oemrawsingh, Rohit, additional, Dorman, Reinhart, additional, Oude Ophius, Ton, additional, Prins, Paco, additional, al Windy, N.Y.Y., additional, Zoet-Nugteren, S.K., additional, Hermanides, Rik, additional, van Eck, Martijn, additional, Scherptong, Roderick, additional, Cornel, J.H., additional, Damman, Peter, additional, Bech, Gerhard, additional, Torquay, R., additional, Kietselaer, Bas, additional, Grzelakowski, Pawel, additional, Krzysztof, Dyrbus, additional, Miekus, Pawel, additional, Przybylski, Andrzej, additional, Zarebinski, Maciej, additional, Balsam, Pawel, additional, Szachniewicz, Joanna, additional, Gierlotka, Marek, additional, Tycinska, Agnieszka, additional, Iniguez Romo, Andres, additional, Fernandez Ortiz, Antonio, additional, Carrasquer Cucarella, Anna, additional, Sanmartin Fernandez, Marcelo, additional, Sionis, Alessandro, additional, Bueno Zamora, Hector, additional, Ferreiro Gutierrez, Jose Luis, additional, Almenar, Luis, additional, Ferreira Gonzalez, Ignacio, additional, Pascual Figal, Domingo A., additional, Almendro Delia, Manuel, additional, Jimenez Fernandez, Miriam, additional, Skeppholm, Mika, additional, Zedigh, Crister, additional, Angeras, Oskar, additional, Lauermann, Jorg, additional, Erlinge, David, additional, Gustafsson, Robin, additional, Mooe, Thomas, additional, Utreras, Alejandro, additional, James, Stefan, additional, Grimfjard, Per, additional, Pedrazzini, Giovanni, additional, Mach, Francois, additional, Fournier, Stephane, additional, Haegeli, Laurent, additional, Beer, Jurg H., additional, Leibundgut, Gregor, additional, Kobza, Richard, additional, Kaiser, Christoph, additional, Kunadian, Vijay, additional, Al-Lamee, Rasha, additional, Gorog, Diana, additional, Khan, Sohail, additional, Trevelyan, Jasper, additional, Toor, Iqbal, additional, Smith, James, additional, Purushottam, Bhaskar, additional, Treasure, Charles, additional, Arena, Frank, additional, Vedere, Amarnath, additional, Henderson, David, additional, Gilani, Syed, additional, Jones, Alonzo, additional, Carrillo-Jimenez, Rodolfo, additional, Gillespie, Eve, additional, Marhefka, Gregary, additional, Wang, David, additional, Olson, Charles, additional, Bloom, Stephen, additional, Iftikhar, Faizan, additional, Brabham, David, additional, McGinty, John, additional, Thompson, Charles, additional, Talano, James, additional, Ginete, Wilson, additional, Williams, Marcus, additional, Masud, Ali, additional, Ariani, Mehrdad, additional, Bitar, Fahed, additional, Wang, Thomas, additional, and Samuelson, Bradley, additional

Published
2022
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14. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Piccini, Jonathan P, primary, Caso, Valeria, additional, Connolly, Stuart J, additional, Fox, Keith A A, additional, Oldgren, Jonas, additional, Jones, W Schuyler, additional, Gorog, Diana A, additional, Durdil, Václav, additional, Viethen, Thomas, additional, Neumann, Christoph, additional, Mundl, Hardi, additional, Patel, Manesh R, additional, Auer, Johann, additional, Hubauer, Martin, additional, Pandzic, Sead, additional, Preishuber, Eva, additional, Primus-Grabscheit, Carina, additional, Reitgruber, Dietmar, additional, Schmalzer, Florian, additional, Adlbrecht, Christopher, additional, Schober, Andreas, additional, Hajos, Johannes, additional, Keil, Christoph, additional, Schratter, Alexandra, additional, Frick, Matthias, additional, Benda, Magdalena Anna, additional, Mächler, Maximilian, additional, Mutschlechner, Beatrix, additional, Saely, Christoph, additional, Sprenger, Lukas, additional, Lichtenauer, Michael, additional, Eber, Miriam, additional, Hoppe, Uta, additional, Kolbitsch, Tobias, additional, Jirak, Peter Michael, additional, Mirna, Moritz, additional, Schönbauer, Robert, additional, Bergler-Klein, Jutta, additional, Hengstenberg, Christian, additional, Stojkovic, Stefan, additional, Scherr, Daniel, additional, Manninger-Wünscher, Martin, additional, Rohrer, Ursula, additional, Stühlinger, Markus, additional, Schgoer, Wilfried, additional, Schwarzl, Jana, additional, Pürerfellner, Helmut, additional, Derndorfer, Michael, additional, Ebner, Christian, additional, Eder, Veronika, additional, Kollias, Georgios, additional, Sturmberger, Thomas, additional, Sieghartsleitner, Stefan, additional, Vijgen, Johan, additional, Koopman, Peter, additional, Dujardin, Karl, additional, Anné, Wim, additional, De Ceuninck, Michel, additional, Tavernier, Rene, additional, Duytschaever, Mattias, additional, Knecht, Sébastien, additional, Missault, Luc, additional, Vandekerckhove, Yves, additional, Rossenbacker, Tom, additional, Ector, Bavo, additional, Charlier, Filip, additional, Debruyne, Philippe, additional, Dewilde, Willem, additional, Janssens, Luc, additional, Roosen, John, additional, Vankelecom, Bart, additional, Heidbuchel, Hein, additional, Delesie, Michiel, additional, Vervoort, Gert, additional, Rombouts, Hans, additional, Vanassche, Thomas, additional, Engelen, Matthias, additional, Verhamme, Peter, additional, Willems, Rik, additional, Constance, Christian, additional, Pranno, Nicolas, additional, Cox, Jafna, additional, Bata, Iqbal, additional, Macle, Laurent, additional, Aguilar, Martin, additional, Tourigny, Julia Cadrin, additional, Dubuc, Marc, additional, Dyrda, Katia, additional, Guerra, Peter, additional, Khairy, Paul, additional, Mondésert, Blandine, additional, Rivard, Léna, additional, Roy, Denis, additional, Tadros, Rafik, additional, Talajic, Mario, additional, Thibault, Bernard, additional, Nault, Isabelle, additional, Blier, Louis, additional, Champagne, Jean, additional, Molin, Franck, additional, O'Hara, Gilles, additional, Philippon, François, additional, Plourde, Benoit, additional, Sarrazin, Jean-François, additional, Steinberg, Christian, additional, Coufal, Zdenek, additional, Balazsik, David, additional, Mikulica, Michal, additional, Zapeca, Jakub, additional, Cermak, Ondrej, additional, Drasnar, Tomas, additional, Falc, Matej, additional, Hornof, Josef, additional, Racz, Blazej, additional, Weissova, Danica, additional, Linkova, Hana, additional, Paskova, Eva, additional, Petr, Robert, additional, Sirakova, Andrea, additional, Kettner, Jiri, additional, Benak, Ales, additional, Holek, Martin, additional, Podpera, Ivo, additional, Podperova, Monika, additional, Vancura, Vlastimil, additional, Jandik, Tomas, additional, Smid, Jiri, additional, Dedek, Vratislav, additional, Banik, Jan, additional, Durdil, Vaclav, additional, Hnat, Tomas, additional, Lellouche, Nicolas, additional, Rouffiac, Ségolène, additional, Taldir, Guillaume, additional, Bridonneau, Valentin, additional, Couffon, Philippe, additional, Daudin, Magalie, additional, Hamon, Cécile, additional, Lacaze, Jonathan, additional, Quentin, Anne, additional, Thebault, Christophe, additional, Boiffard, Emmanuel, additional, Billon, Olivier, additional, Miette, Fabien, additional, Pouliquen, Hervé, additional, Turlotte, Guillaume, additional, Gorka, Hervé, additional, Albert, Franck, additional, Bayle, Sandrine, additional, Bensaid, Reda, additional, Dasoveanu, Madalina, additional, Demichili, Thibaud, additional, Dutoiu, Teodora, additional, Khalil, Cliff, additional, Loghin, Caterina, additional, Range, Grégoire, additional, Roussel, Laurent, additional, Socié, Pierre, additional, Thuaire, Christophe, additional, Extramiana, Fabrice, additional, Algalarrondo, Vincent, additional, Boughanmi, Haten, additional, El Mansour, Noreddine, additional, Mohammad, Usman, additional, Sellier, Romain, additional, Elbaz, Meyer, additional, Laperche, Clémence, additional, Maury, Philippe, additional, Kiss, Robert, additional, Borsanyi, Tunde, additional, Gingl, Zoltan, additional, Polgar, Balaza, additional, Benczur, Bela, additional, Bodor, Alexandra, additional, Hepp, Tamas, additional, Malati, Eva, additional, Nagy, Laszlo, additional, Erdei, Norbert, additional, Kapus, Jozsef, additional, Kapus, Katalin, additional, Toth, Brigitta, additional, Matoltsy, Andras, additional, Kiss, Tunde, additional, Merkely, Bela, additional, Herczeg, Szilvia, additional, Kiss, Orsolya, additional, Sallo, Zoltan, additional, Toth, Kalman, additional, Habon, Tamas, additional, Rabai, Miklos, additional, Totsimon, Kinga, additional, Zilahi, Zsolt, additional, Bencze, Gabriella, additional, Santa, Janos, additional, Aradi, Daniel, additional, Kelemen, Barbara, additional, Bolognese, Leonardo, additional, Nesti, Martina, additional, Notarstefano, Pasquale Giovanni, additional, D'Orazio, Simona, additional, Cosmi, Franco, additional, Becattini, Cecilia, additional, Agnelli, Giancarlo, additional, Broccatelli, Belinda, additional, Mosconi, Maria Giulia, additional, Paciaroni, Maurizio, additional, Urbini, Chiara, additional, Parato, Vito Maurizio, additional, Notaristefani, Camilla, additional, Scarano, Michele, additional, Ameri, Pietro, additional, Ghigliotti, Giorgio, additional, Guglielmi, Giulia, additional, Lotti, Roberta, additional, Merlo, Andrea Carlo, additional, Muiesan, Maria Lorenza, additional, Abondio, Andrea, additional, Berasi, Caterina, additional, Mattiuzzo, Elena, additional, Mutti, Claudio, additional, Salvetti, Massimo, additional, Pignatelli, Pasquale, additional, Menichelli, Danilo, additional, Pastori, Daniele, additional, Tamiya, Eiji, additional, Matsumoto, Takahiro, additional, Takabe, Tomosato, additional, Yamamoto, Shoichi, additional, Yamashita, Haruyo, additional, Higashiue, Shinichi, additional, Furuya, Onichi, additional, Hiramatsu, Norihiko, additional, Kasuga, Kensuke, additional, Kojima, Saburo, additional, Komooka, Masatoshi, additional, Kuroyanagi, Satoshi, additional, Matsuura, Makoto, additional, Takemoto, Tetsushi, additional, Yamamoto, Shuji, additional, Saito, Katusmi, additional, Abe, Takuro, additional, Ishida, Issei, additional, Iwanami, Yuji, additional, Kataoka, Shohei, additional, Moriyama, Tetsu, additional, Murohashi, Akira, additional, Sasaki, Akihito, additional, Nakamura, Yuichiro, additional, Ueno, Tetsuya, additional, Shimane, Akira, additional, Hamana, Tomoyo, additional, Ichibori, Hirotoshi, additional, Inoue, Tomohiro, additional, Itoh, Mitsuaki, additional, Iwane, Seigo, additional, Kawai, Hiroya, additional, Kokawa, Tatsuya, additional, Masumoto, Akiko, additional, Matsuo, Koki, additional, Miyata, Taishi, additional, Nakano, Shinsuke, additional, Oishi, Shogo, additional, Onishi, Tetsuari, additional, Sawada, Takahiro, additional, Saito, Takayuki, additional, Shoda, Mitsuhiko, additional, Takahashi, Nobuyuki, additional, Takaya, Tomofumi, additional, Taniguchi, Yasuyo, additional, Tsukamoto, Shota, additional, Tsukishiro, Yasue, additional, Tsukiyama, Yoshiro, additional, Tsunamoto, Hiroshi, additional, Uzu, Kenzo, additional, Yamamoto, Hiroyuki, additional, Yamamoto, Tetsuya, additional, Yokoi, Kiminobu, additional, Yoshida, Chiaki, additional, Watanabe, Nobuhiro, additional, Betsuyaku, Tetsuo, additional, Adachi, Kumiko, additional, Awane, Kouichi, additional, Goto, Daisuke, additional, Sakakibara, Mamoru, additional, Watanabe, Masashi, additional, Ueno, Hideki, additional, Hiroe, Yoshitaka, additional, Matsuo, Koshi, additional, Ayata, Kenji, additional, Fukuda, Ko, additional, Hata, Yoshiki, additional, Hashimoto, Katsushi, additional, Matsumi, Hiroaki, additional, Nikaido, Akira, additional, Okamoto, Shuichi, additional, Sime, Iveta, additional, Stirna, Valters, additional, Reinholde, Ilze, additional, Hansone, Silvija, additional, Kozlovska, Anita, additional, Romanova, Janina, additional, Klincare, Dace, additional, Pontaga, Natalja, additional, Dirmans, Igors, additional, Kalnins, Artis, additional, Upite, Dana, additional, Gersamija, Arcils, additional, Teleznikovs, Arturs, additional, Rozkova, Nadezda, additional, Safro, Jelena, additional, Anguera Camós, Ignasi, additional, Domenico Dallaglio, Paolo, additional, Salguero Bodes, Rafael, additional, Arnbas, Fernando, additional, Borrego, Luis, additional, Marco, Alvaro, additional, Jimenez, Javier Ramos, additional, Gómez-Doblas, Juan José, additional, Pérez Cabeza, Alejandro, additional, Ferreira Gonzålez, Ignacio, additional, Limeres Freire, Javier, additional, Lopez Grau, Merce, additional, Viñolas Prat, Xavier, additional, Moreno Weidmann, Zoraida, additional, Guerra Ramos, Jose Maria, additional, Alonso Martin, Maria Concepcion, additional, Campos Garcia, Bieito, additional, Mogro Carranza, Javier Mauricio, additional, Mendez Zurita, Francisco Javier, additional, Rodriguez Font, Enrique, additional, Gonzales Matos, Carlos Eduardo, additional, García Hernando, Víctor, additional, Lindholm, Carl-Johan, additional, Thulin, Jörgen, additional, Wallén, Håkan, additional, Hagwall, Kristina, additional, Eliasson, Ken, additional, Lundvall, Martin, additional, Olsson, Jens, additional, Kjellman, Björn, additional, Lind, Markus, additional, Johansson, Lars, additional, Svedberg, Niclas, additional, Berglund, Stefan, additional, Söderberg, Julia, additional, Zedigh, Christer, additional, Mooe, Thomas, additional, Axelsson, Mattias, additional, Binsell, Emil, additional, Huber, Daniel, additional, Müller, Christian, additional, Danier, Isabelle, additional, Kühne, Michael, additional, Okamura, Bernhard, additional, Schoepfer, Hadrien, additional, Simmen, Cornelia, additional, Reichlin, Tobias, additional, Chollet, Laurève, additional, Lam, Anna, additional, Wittmer, Severin, additional, Rickli, Hans, additional, Gall, Christian, additional, Hametner, Greta, additional, Intorp, Stephanie, additional, Luescher, Daniel, additional, Haegeli, Laurent, additional, Berg, Jan Christopher, additional, Ebrahimi, Ramin, additional, Auricchio, Angelo, additional, Crljenica, Carmela, additional, Moccetti, Tizziano, additional, Monti, Cristina, additional, Pasotti, Elena, additional, Petrova, Iveta, additional, Rossi, Mariagrazia, additional, Mach, François, additional, Namdar, Mehdi, additional, de Groot, Joris, additional, Proost, Virginnio, additional, Neefs, Joline, additional, Linz, Dominik, additional, van Stipdonk, Twan, additional, den Uijl, Dennis, additional, Alings, Marco, additional, Schaap, Jeroen, additional, Segers, Dolf, additional, Wouters, Noemi, additional, Bartels, Louis, additional, Tieleman, Robert, additional, Pisters, Ron, additional, de Vries, Tim, additional, Selig, Jaap, additional, Kuijper, Aaf, additional, Bot, Pieter, additional, Keijzers, Mitran, additional, Verdel, Gerardus, additional, Tukkie, Raymond, additional, van den Bos, Ewout, additional, Kauer, Floris, additional, Oemrawsingh, Rohit, additional, Stevenhagen, Jeroen, additional, van Es, Jan, additional, Lip, Gregory, additional, Gupta, Dhiraj, additional, Kotalczyk, Agnieszka, additional, Gunstone, Anthony, additional, Brixey, Richard David, additional, Gorog, Diana, additional, Dinarvand, Danial, additional, Gue, Ying, additional, Kanji, Rahim, additional, Memtsas, Vassilios, additional, Senior, Roxy, additional, Bioh, Gabriel, additional, Wong, Yuk-Ki, additional, and Child, Nick, additional

Published
2022
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16. Corrigendum to: Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST-AFNET 4 trial

Author

Metzner, Andreas, primary, Suling, Anna, additional, Brandes, Axel, additional, Breithardt, Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, Lars, additional, Elvan, Arif, additional, Goette, Andreas, additional, Haegeli, Laurent M, additional, Heidbuchel, Hein, additional, Kautzner, Josef, additional, Kuck, Karl-Heinz, additional, Mont, Luis, additional, Ng, G Andre, additional, Szumowski, Lukasz, additional, Themistoclakis, Sakis, additional, van Gelder, Isabelle C, additional, Vardas, Panos, additional, Wegscheider, Karl, additional, Willems, Stephan, additional, and Kirchhof, Paulus, additional

Published
2021
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18. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Breithardt, Günter, Bax, Jeroen, Benninger, Gerlinde, Blomstrom-Lundqvist, Carina, Boriani, Giuseppe, Brandes, Axel, Brown, Helen, Brueckmann, Martina, Calkins, Hugh, Calvert, Melanie, Christoffels, Vincent, Crijns, Harry, Dobrev, Dobromir, Ellinor, Patrick, Fabritz, Larissa, Fetsch, Thomas, Freedman, S. Ben, Gerth, Andrea, Goette, Andreas, Guasch, Eduard, Hack, Guido, Haegeli, Laurent, Hatem, Stephane, Haeusler, Karl Georg, Heidbüchel, Hein, Heinrich-Nols, Jutta, Hidden-Lucet, Francoise, Hindricks, Gerd, Juul-Möller, Steen, Kääb, Stefan, Kappenberger, Lukas, Kespohl, Stefanie, Kotecha, Dipak, Lane, Deirdre A., Leute, Angelika, Lewalter, Thorsten, Meyer, Ralf, Mont, Lluis, Münzel, Felix, Nabauer, Michael, Nielsen, Jens C., Oeff, Michael, Oldgren, Jonas, Oto, Ali, Piccini, Jonathan P., Pilmeyer, Art, Potpara, Tatjana, Ravens, Ursula, Reinecke, Holger, Rostock, Thomas, Rustige, Joerg, Savelieva, Irene, Schnabel, Renate, Schotten, Ulrich, Schwichtenberg, Lars, Sinner, Moritz F., Steinbeck, Gerhard, Stoll, Monika, Tavazzi, Luigi, Themistoclakis, Sakis, Tse, Hung Fat, Van Gelder, Isabelle C., Vardas, Panagiotis E., Varpula, Timo, Vincent, Alphons, Werring, David, Willems, Stephan, Ziegler, André, Lip, Gregory Y.H., and Camm, A. John

Published
2016
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20. Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure

Author

Rillig, Andreas, primary, Magnussen, Christina, additional, Ozga, Ann-Kathrin, additional, Suling, Anna, additional, Brandes, Axel, additional, Breithardt, Günter, additional, Camm, A. John, additional, Crijns, Harry J.G.M., additional, Eckardt, Lars, additional, Elvan, Arif, additional, Goette, Andreas, additional, Gulizia, Michele, additional, Haegeli, Laurent, additional, Heidbuchel, Hein, additional, Kuck, Karl-Heinz, additional, Ng, Andre, additional, Szumowski, Lukasz, additional, van Gelder, Isabelle, additional, Wegscheider, Karl, additional, and Kirchhof, Paulus, additional

Published
2021
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21. Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial

Author

Metzner, Andreas, primary, Suling, Anna, additional, Brandes, Axel, additional, Breithardt, , Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, , Lars, additional, Elvan, , Arif, additional, Goette, , Andreas, additional, Haegeli, , Laurent M, additional, Heidbuchel, , Hein, additional, Kautzner, , Josef, additional, Kuck, , Karl-Heinz, additional, Mont, , Luis, additional, Ng, G Andre, additional, Szumowski, , Lukasz, additional, Themistoclakis, , Sakis, additional, van Gelder, , Isabelle C, additional, Vardas, , Panos, additional, Wegscheider, , Karl, additional, Willems, , Stephan, additional, and Kirchhof, Paulus, additional

Published
2021
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22. Document de consensus sur la prise en charge du cholestérol LDL

Author

Mach, François, Gallino, Augusto, Haegeli, Laurent M., Kobza, Richard, Koskinas, Konstantinos, Miserez, André, Nanchen, David, Pedrazzini, Giovanni, Räber, Lorenz, Sudano, Isabella, Twerenbold, Raphael, Noll, Georg, Amstein, Ruth, and Lüscher, Thomas F.

Subjects
low density lipoprotein, cholesterol, article, consensus, development, human, low density lipoprotein cholesterol level
Abstract

L’hypothèse établissant un lien causal entre le cholestérol à lipoprotéines de basse densité (c-LDL pour low density lipoprotein en anglais) et les événements cliniques liés à l’athérosclérose, tels l’infarctus aigu du myocarde, l’accident cérébral vasculaire (AVC) ou l’artériopathie des membres inférieurs a abouti à l’un des concepts le mieux documenté scientifiquement et des plus abouti en médecine. Les recommandations émises en 2019 par l’ESC/EAS pour la prise en charge des dyslipidémies se basent sur les dernières avancées en recherche ainsi que l’accès à de nouveaux traitements médicamenteux. Elles résument l’état actuel des évidences scientifiques et émettent de nouvelles recommandations. Les taux plasmatiques de c-LDL sont particulièrement élevés chez l’homme adulte, contrairement à la plupart des espèces animalesL’athérosclérose est typiquement une maladie humaine, et elle est très fréquenteLes taux de c-LDL sont principalement liés à la qualité et quantité de l’alimentation, ainsi que la sédentarité et la tabagismeLes taux de c-LDL sont parfois déterminés génétiquement et augmentent avec l’âgeLe taux de c-LDL est directement associé au développement des plaques d’athéroscléroseLes plaques athérosclérose sont responsables de la majorité des infarctus du myocarde et des AVC, et ainsi d’une grande partie des décès cardiovasculairesLes mutations génétiques associées à des taux sanguins de c-LDL abaissé protègent contre la survenue d'infarctus du myocarde et de la mort subite, alors que celles associées à des taux élevés de c-LDL peuvent provoquer les pathologies liées à l’athérosclérose déjà mentionnéesDifférentes thérapies médicamenteuses permettent de réduire les taux plasmatiques de c-LDLLes principaux médicaments hypolipémiants sont les statines, l’ézétimibe et les inhibiteurs de la protéine PCSK9Ces traitements hypolipémiants réduisent considérablement le risque d’infarctus du myocarde, d’AVC et de morts subitesPlus le taux de c-LDL est bas, plus le risque de crise cardiaque, d'AVC et risque de mort subite est faible (le plus bas, le mieux «the lower, the better»)Le risque cardiovasculaire de développer un infarctus du myocarde, un AVC ou une mort subit détermine l'utilisation de traitements hypolipémiant ainsi que leurs posologie.Les patients qui ont présenté un événement clinique lié à des lésions d’athérosclérose, ou chez qui des lésions d’athérosclérose ont été mises en évidence (principalement par l’imagerie) sont à risque très élevé de récurrence d'événements cardiaquesPour les patients à haut et à très haut risque, la valeur cible du c-LDL doit être

Published
2021

27. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial

Author

Willems, Stephan, primary, Borof, Katrin, additional, Brandes, Axel, additional, Breithardt, Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, Lars, additional, Gessler, Nele, additional, Goette, Andreas, additional, Haegeli, Laurent M, additional, Heidbuchel, Hein, additional, Kautzner, Josef, additional, Ng, G André, additional, Schnabel, Renate B, additional, Suling, Anna, additional, Szumowski, Lukasz, additional, Themistoclakis, Sakis, additional, Vardas, Panos, additional, van Gelder, Isabelle C, additional, Wegscheider, Karl, additional, and Kirchhof, Paulus, additional

Published
2021
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28. High Incidence of Inappropriate Alarms in Patients with Wearable Cardioverter-Defibrillators: Findings from the Swiss WCD Registry

Author

Kovacs, Boldizsar, primary, Burri, Haran, additional, Buehler, Andres, additional, Reek, Sven, additional, Sticherling, Christian, additional, Schaer, Beat, additional, Linka, Andre, additional, Ammann, Peter, additional, Müller, Andreas S., additional, Dzemali, Omer, additional, Kobza, Richard, additional, Schindler, Matthias, additional, Haegeli, Laurent, additional, Mayer, Kurt, additional, Eriksson, Urs, additional, Herrera-Siklody, Claudia, additional, Reichlin, Tobias, additional, Steffel, Jan, additional, Saguner, Ardan M., additional, and Duru, Firat, additional

Published
2021
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29. B-PO02-180 HIGH BURDEN OF INAPPROPRIATE ALARMS BY THE WEARABLE CARDIOVERTER-DEFIBRILLATOR IN OBESE PATIENTS - FINDINGS FROM THE SWISS WCD REGISTRY

Author

Kovacs, Boldizsar, primary, Burri, Haran, additional, Buehler, Andreas, additional, Reek, Sven, additional, Sticherling, Christian, additional, Linka, Andre, additional, Ammann, Peter, additional, Mueller, Andreas S., additional, Dzemali, Omer, additional, Kobza, Richard, additional, Schindler, Matthias, additional, Haegeli, Laurent M., additional, Mayer, Kurt, additional, Eriksson, Urs, additional, Schlaepfer, Juerg, additional, Reichlin, Tobias, additional, Steffel, Jan, additional, Saguner, Ardan M., additional, and Duru, Firat, additional

Published
2021
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31. Modernes Lipid-Management

Author

Lscher, Thomas F., Gallino, Augusto, Haegeli, Laurent M., Kobza, Richard, Koskinas, Konstantinos, Miserez, Andr, Nanchen, David, Noll, Georg, Pedrazzini, Giovanni, Rber, Lorenz, Sudano, Isabella, Twerenbold, Raphael, Amstein, Ruth, and Mach, Franois

Subjects
Cardiology and Cardiovascular Medicine
Published
2020

32. High Incidence of Inappropriate Alarms in Patients with Wearable Cardioverter-Defibrillators: Findings from the Swiss WCD Registry

Author

Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Burri, Haran, Buehler, Andres, Reek, Sven, Sticherling, Christian; https://orcid.org/0000-0001-8428-7050, Schaer, Beat, Linka, André, Ammann, Peter, Müller, Andreas S, Dzemali, Omer; https://orcid.org/0000-0001-7910-5152, Kobza, Richard; https://orcid.org/0000-0003-3988-7262, Schindler, Matthias; https://orcid.org/0000-0001-7232-693X, Haegeli, Laurent; https://orcid.org/0000-0002-9830-2271, Mayer, Kurt, Eriksson, Urs; https://orcid.org/0000-0003-1217-9696, Herrera-Siklody, Claudia; https://orcid.org/0000-0001-6881-3073, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Steffel, Jan; https://orcid.org/0000-0002-1477-9153, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Duru, Firat; https://orcid.org/0000-0002-4748-0158, Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Burri, Haran, Buehler, Andres, Reek, Sven, Sticherling, Christian; https://orcid.org/0000-0001-8428-7050, Schaer, Beat, Linka, André, Ammann, Peter, Müller, Andreas S, Dzemali, Omer; https://orcid.org/0000-0001-7910-5152, Kobza, Richard; https://orcid.org/0000-0003-3988-7262, Schindler, Matthias; https://orcid.org/0000-0001-7232-693X, Haegeli, Laurent; https://orcid.org/0000-0002-9830-2271, Mayer, Kurt, Eriksson, Urs; https://orcid.org/0000-0003-1217-9696, Herrera-Siklody, Claudia; https://orcid.org/0000-0001-6881-3073, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Steffel, Jan; https://orcid.org/0000-0002-1477-9153, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, and Duru, Firat; https://orcid.org/0000-0002-4748-0158

Abstract

BACKGROUND: The wearable cardioverter defibrillator (WCD) uses surface electrodes to detect arrhythmia before initiating a treatment sequence. However, it is also prone to inappropriate detection due to artefacts. OBJECTIVE: The aim of this study is to assess the alarm burden in patients and its impact on clinical outcomes. METHODS: Patients from the nationwide Swiss WCD Registry were included. Clinical characteristics and data were obtained from the WCDs. Arrhythmia recordings ≥30 s in length were analysed and categorized as VT/VF, atrial fibrillation (AF), supraventricular tachycardia (SVT) or artefact. RESULTS: A total of 10653 device alarms were documented in 324 of 456 patients (71.1%) over a mean WCD wear-time of 2.0 ± 1.6 months. Episode duration was 30 s or more in 2996 alarms (28.2%). One hundred and eleven (3.7%) were VT/VF episodes. The remaining recordings were inappropriate detections (2736 (91%) due to artefacts; 117 (3.7%) AF; 48 (1.6%) SVT). Two-hundred and seven patients (45%) had three or more alarms per month. Obesity was significantly associated with three or more alarms per month (p = 0.01, 27.7% vs. 15.9%). High alarm burden was not associated with a lower average daily wear time (20.8 h vs. 20.7 h, p = 0.785) or a decreased implantable cardioverter defibrillator implantation rate after stopping WCD use (48% vs. 47.3%, p = 0.156). CONCLUSIONS: In patients using WCDs, alarms emitted by the device and impending inappropriate shocks were frequent and most commonly caused by artefacts. A high alarm burden was associated with obesity but did not lead to a decreased adherence.

Published
2021

33. Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Breithardt, Günter, Aliot, Etienne, Al Khatib, Sana, Apostolakis, Stavros, Auricchio, Angelo, Bailleul, Christophe, Bax, Jeroen, Benninger, Gerlinde, Blomstrom-Lundqvist, Carina, Boersma, Lucas, Boriani, Giuseppe, Brandes, Axel, Brown, Helen, Brueckmann, Martina, Calkins, Hugh, Casadei, Barbara, Clemens, Andreas, Crijns, Harry, Derwand, Roland, Dobrev, Dobromir, Ezekowitz, Michael, Fetsch, Thomas, Gerth, Andrea, Gillis, Anne, Gulizia, Michele, Hack, Guido, Haegeli, Laurent, Hatem, Stephane, Georg Häusler, Karl, Heidbüchel, Hein, Hernandez-Brichis, Jessica, Jais, Pierre, Kappenberger, Lukas, Kautzner, Joseph, Kim, Steven, Kuck, Karl-Heinz, Lane, Deirdre, Leute, Angelika, Lewalter, Thorsten, Meyer, Ralf, Mont, Lluis, Moses, Gregory, Mueller, Markus, Münzel, Felix, Näbauer, Michael, Nielsen, Jens Cosedis, Oeff, Michael, Oto, Ali, Pieske, Burkert, Pisters, Ron, Potpara, Tatjana, Rasmussen, Lars, Ravens, Ursula, Reiffel, James, Richard-Lordereau, Isabelle, Schäfer, Herbert, Schotten, Ulrich, Stegink, Wim, Stein, Kenneth, Steinbeck, Gerhard, Szumowski, Lukasz, Tavazzi, Luigi, Themistoclakis, Sakis, Thomitzek, Karen, Van Gelder, Isabelle C., von Stritzky, Berndt, Vincent, Alphons, Werring, David, Willems, Stephan, Lip, Gregory Y. H., and Camm, A. John

Published
2013
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36. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Lip, Gregory Y.H., Van Gelder, Isabelle C., Bax, Jeroen, Hylek, Elaine, Kaab, Stefan, Schotten, Ulrich, Wegscheider, Karl, Boriani, Giuseppe, Brandes, Axel, Ezekowitz, Michael, Diener, Hans, Haegeli, Laurent, Heidbuchel, Hein, Lane, Deirdre, Mont, Luis, Willems, Stephan, Dorian, Paul, Aunes-Jansson, Maria, Blomstrom-Lundqvist, Carina, Borentain, Maria, Breitenstein, Stefanie, Brueckmann, Martina, Cater, Nilo, Clemens, Andreas, Dobrev, Dobromir, Dubner, Sergio, Edvardsson, Nils G., Friberg, Leif, Goette, Andreas, Gulizia, Michele, Hatala, Robert, Horwood, Jenny, Szumowski, Lukas, Kappenberger, Lukas, Kautzner, Josef, Leute, Angelika, Lobban, Trudie, Meyer, Ralf, Millerhagen, Jay, Morgan, John, Muenzel, Felix, Nabauer, Michael, Baertels, Christoph, Oeff, Michael, Paar, Dieter, Polifka, Juergen, Ravens, Ursula, Rosin, Ludger, Stegink, W., Steinbeck, Gerhard, Vardas, Panos, Vincent, Alphons, Walter, Maureen, Breithardt, Günter, and Camm, A. John

Published
2012
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40. Impact of contact force sensing technology on outcome of catheter ablation of idiopathic pre-mature ventricular contractions originating from the outflow tracts

Author

Reichlin, Tobias, primary, Baldinger, Samuel H, additional, Pruvot, Etienne, additional, Bisch, Laurence, additional, Ammann, Peter, additional, Altmann, David, additional, Berte, Benjamin, additional, Kobza, Richard, additional, Haegeli, Laurent, additional, Schlatzer, Christian, additional, Mueller, Andreas, additional, Namdar, Mehdi, additional, Shah, Dipen, additional, Burri, Haran, additional, Conte, Giulio, additional, Auricchio, Angelo, additional, Knecht, Sven, additional, Osswald, Stefan, additional, Asatryan, Babken, additional, Seiler, Jens, additional, Roten, Laurent, additional, Kühne, Michael, additional, and Sticherling, Christian, additional

Published
2020
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41. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation

Author

Kirchhof, Paulus, primary, Camm, A. John, additional, Goette, Andreas, additional, Brandes, Axel, additional, Eckardt, Lars, additional, Elvan, Arif, additional, Fetsch, Thomas, additional, van Gelder, Isabelle C., additional, Haase, Doreen, additional, Haegeli, Laurent M., additional, Hamann, Frank, additional, Heidbüchel, Hein, additional, Hindricks, Gerhard, additional, Kautzner, Josef, additional, Kuck, Karl-Heinz, additional, Mont, Lluis, additional, Ng, G. Andre, additional, Rekosz, Jerzy, additional, Schoen, Norbert, additional, Schotten, Ulrich, additional, Suling, Anna, additional, Taggeselle, Jens, additional, Themistoclakis, Sakis, additional, Vettorazzi, Eik, additional, Vardas, Panos, additional, Wegscheider, Karl, additional, Willems, Stephan, additional, Crijns, Harry J.G.M., additional, and Breithardt, Günter, additional

Published
2020
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43. Modernes Lipid-Management

Author

Lscher, Thomas F., primary, Gallino, Augusto, additional, Haegeli, Laurent M., additional, Kobza, Richard, additional, Koskinas, Konstantinos, additional, Miserez, Andr, additional, Nanchen, David, additional, Noll, Georg, additional, Pedrazzini, Giovanni, additional, Rber, Lorenz, additional, Sudano, Isabella, additional, Twerenbold, Raphael, additional, Amstein, Ruth, additional, and Mach, Franois, additional

Published
2020
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45. Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial.

Author

Metzner, Andreas, Suling, Anna, Brandes, Axel, Camm, A John, Crijns, Harry J G M, Ng, G Andre, Kirchhof, Paulus, Breithardt, Günter, Eckardt, Lars, Elvan, Arif, Goette, Andreas, Haegeli, Laurent M, Heidbuchel, Hein, Kautzner, Josef, Kuck, Karl-Heinz, Mont, Luis, Szumowski, Lukasz, Themistoclakis, Sakis, van Gelder, Isabelle C, and Vardas, Panos

Abstract

Aims: Treatment patterns were compared between randomized groups in EAST-AFNET 4 to assess whether differences in anticoagulation, therapy of concomitant diseases, or intensity of care can explain the clinical benefit achieved with early rhythm control in EAST-AFNET 4.Methods and Results: Cardiovascular treatment patterns and number of visits were compared between randomized groups in EAST-AFNET 4. Oral anticoagulation was used in >90% of patients during follow-up without differences between randomized groups. There were no differences in treatment of concomitant conditions between groups. The type of rhythm control varied by country and centre. Over time, antiarrhythmic drugs were given to 1171/1395 (84%) patients in early therapy, and to 202/1394 (14%) in usual care. Atrial fibrillation (AF) ablation was performed in 340/1395 (24%) patients randomized to early therapy, and in 168/1394 (12%) patients randomized to usual care. 97% of rhythm control therapies were within class I and class III recommendations of AF guidelines. Patients randomized to early therapy transmitted 297 166 telemetric electrocardiograms (ECGs) to a core lab. In total, 97 978 abnormal ECGs were sent to study sites. The resulting difference between study visits was low (0.06 visits/patient/year), with slightly more visits in early therapy (usual care 0.39 visits/patient/year; early rhythm control 0.45 visits/patient/year, P < 0.001), mainly due to visits for symptomatic AF recurrences or recurrent AF on telemetric ECGs.Conclusion: The clinical benefit of early, systematic rhythm control therapy was achieved using variable treatment patterns of antiarrhythmic drugs and AF ablation, applied within guideline recommendations. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial.

Author

Willems, Stephan, Borof, Katrin, Brandes, Axel, Breithardt, Günter, Camm, A John, Crijns, Harry J G M, Eckardt, Lars, Gessler, Nele, Goette, Andreas, Haegeli, Laurent M, Heidbuchel, Hein, Kautzner, Josef, Ng, G André, Schnabel, Renate B, Suling, Anna, Szumowski, Lukasz, Themistoclakis, Sakis, Vardas, Panos, Gelder, Isabelle C van, and Wegscheider, Karl

Subjects
ATRIAL fibrillation, SYMPTOMS, ABLATION techniques, MYOCARDIAL depressants, CLINICAL trials
Abstract

Aims Clinical practice guidelines restrict rhythm control therapy to patients with symptomatic atrial fibrillation (AF). The EAST-AFNET 4 trial demonstrated that early, systematic rhythm control improves clinical outcomes compared to symptom-directed rhythm control. Methods and results This prespecified EAST-AFNET 4 analysis compared the effect of early rhythm control therapy in asymptomatic patients (EHRA score I) to symptomatic patients. Primary outcome was a composite of death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome, analyzed in a time-to-event analysis. At baseline, 801/2633 (30.4%) patients were asymptomatic [mean age 71.3 years, 37.5% women, mean CHA2DS2-VASc score 3.4, 169/801 (21.1%) heart failure]. Asymptomatic patients randomized to early rhythm control (395/801) received similar rhythm control therapies compared to symptomatic patients [e.g. AF ablation at 24 months: 75/395 (19.0%) in asymptomatic; 176/910 (19.3%) symptomatic patients, P = 0.672]. Anticoagulation and treatment of concomitant cardiovascular conditions was not different between symptomatic and asymptomatic patients. The primary outcome occurred in 79/395 asymptomatic patients randomized to early rhythm control and in 97/406 patients randomized to usual care (hazard ratio 0.76, 95% confidence interval [0.6; 1.03]), almost identical to symptomatic patients. At 24 months follow-up, change in symptom status was not different between randomized groups (P = 0.19). Conclusion The clinical benefit of early, systematic rhythm control was not different between asymptomatic and symptomatic patients in EAST-AFNET 4. These results call for a shared decision discussing the benefits of rhythm control therapy in all patients with recently diagnosed AF and concomitant cardiovascular conditions (EAST-AFNET 4; ISRCTN04708680; NCT01288352; EudraCT2010-021258-20). [ABSTRACT FROM AUTHOR]

Published
2022
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