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1. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature

Author

van Jaarsveld, Richard H., Reilly, Jack, Cornips, Marie-Claire, Hadders, Michael A., Agolini, Emanuele, Ahimaz, Priyanka, Anyane-Yeboa, Kwame, Bellanger, Severine Audebert, van Binsbergen, Ellen, van den Boogaard, Marie-Jose, Brischoux-Boucher, Elise, Caylor, Raymond C., Ciolfi, Andrea, van Essen, Ton A.J., Fontana, Paolo, Hopman, Saskia, Iascone, Maria, Javier, Margaret M., Kamsteeg, Erik-Jan, Kerkhof, Jennifer, Kido, Jun, Kim, Hyung-Goo, Kleefstra, Tjitske, Lonardo, Fortunato, Lai, Abbe, Lev, Dorit, Levy, Michael A., Lewis, M.E. Suzanne, Lichty, Angie, Mannens, Marcel M.A.M., Matsumoto, Naomichi, Maya, Idit, McConkey, Haley, Megarbane, Andre, Michaud, Vincent, Miele, Evelina, Niceta, Marcello, Novelli, Antonio, Onesimo, Roberta, Pfundt, Rolph, Popp, Bernt, Prijoles, Eloise, Relator, Raissa, Redon, Sylvia, Rots, Dmitrijs, Rouault, Karen, Saida, Ken, Schieving, Jolanda, Tartaglia, Marco, Tenconi, Romano, Uguen, Kevin, Verbeek, Nienke, Walsh, Christopher A., Yosovich, Keren, Yuskaitis, Christopher J., Zampino, Giuseppe, Sadikovic, Bekim, Alders, Mariëlle, and Oegema, Renske

Published
2023
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4. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature

Author

Genetica Sectie Genoomdiagnostiek, CMM Groep Lens, Cancer, Child Health, Genetica Klinische Genetica, Brain, van Jaarsveld, Richard H, Reilly, Jack, Cornips, Marie-Claire, Hadders, Michael A, Agolini, Emanuele, Ahimaz, Priyanka, Anyane-Yeboa, Kwame, Bellanger, Severine Audebert, van Binsbergen, Ellen, van den Boogaard, Marie-Jose, Brischoux-Boucher, Elise, Caylor, Raymond C, Ciolfi, Andrea, van Essen, Ton A J, Fontana, Paolo, Hopman, Saskia, Iascone, Maria, Javier, Margaret M, Kamsteeg, Erik-Jan, Kerkhof, Jennifer, Kido, Jun, Kim, Hyung-Goo, Kleefstra, Tjitske, Lonardo, Fortunato, Lai, Abbe, Lev, Dorit, Levy, Michael A, Lewis, M E Suzanne, Lichty, Angie, Mannens, Marcel M A M, Matsumoto, Naomichi, Maya, Idit, McConkey, Haley, Megarbane, Andre, Michaud, Vincent, Miele, Evelina, Niceta, Marcello, Novelli, Antonio, Onesimo, Roberta, Pfundt, Rolph, Popp, Bernt, Prijoles, Eloise, Relator, Raissa, Redon, Sylvia, Rots, Dmitrijs, Rouault, Karen, Saida, Ken, Schieving, Jolanda, Tartaglia, Marco, Tenconi, Romano, Uguen, Kevin, Verbeek, Nienke, Walsh, Christopher A, Yosovich, Keren, Yuskaitis, Christopher J, Zampino, Giuseppe, Sadikovic, Bekim, Alders, Mariëlle, Oegema, Renske, Genetica Sectie Genoomdiagnostiek, CMM Groep Lens, Cancer, Child Health, Genetica Klinische Genetica, Brain, van Jaarsveld, Richard H, Reilly, Jack, Cornips, Marie-Claire, Hadders, Michael A, Agolini, Emanuele, Ahimaz, Priyanka, Anyane-Yeboa, Kwame, Bellanger, Severine Audebert, van Binsbergen, Ellen, van den Boogaard, Marie-Jose, Brischoux-Boucher, Elise, Caylor, Raymond C, Ciolfi, Andrea, van Essen, Ton A J, Fontana, Paolo, Hopman, Saskia, Iascone, Maria, Javier, Margaret M, Kamsteeg, Erik-Jan, Kerkhof, Jennifer, Kido, Jun, Kim, Hyung-Goo, Kleefstra, Tjitske, Lonardo, Fortunato, Lai, Abbe, Lev, Dorit, Levy, Michael A, Lewis, M E Suzanne, Lichty, Angie, Mannens, Marcel M A M, Matsumoto, Naomichi, Maya, Idit, McConkey, Haley, Megarbane, Andre, Michaud, Vincent, Miele, Evelina, Niceta, Marcello, Novelli, Antonio, Onesimo, Roberta, Pfundt, Rolph, Popp, Bernt, Prijoles, Eloise, Relator, Raissa, Redon, Sylvia, Rots, Dmitrijs, Rouault, Karen, Saida, Ken, Schieving, Jolanda, Tartaglia, Marco, Tenconi, Romano, Uguen, Kevin, Verbeek, Nienke, Walsh, Christopher A, Yosovich, Keren, Yuskaitis, Christopher J, Zampino, Giuseppe, Sadikovic, Bekim, Alders, Mariëlle, and Oegema, Renske

Published
2023

8. Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC

Author

Abad, Maria Alba, primary, Gupta, Tanmay, additional, Hadders, Michael A., additional, Meppelink, Amanda, additional, Wopken, J. Pepijn, additional, Blackburn, Elizabeth, additional, Zou, Juan, additional, Gireesh, Anjitha, additional, Buzuk, Lana, additional, Kelly, David A., additional, McHugh, Toni, additional, Rappsilber, Juri, additional, Lens, Susanne M.A., additional, and Jeyaprakash, A. Arockia, additional

Published
2022
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9. Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC

Author

CMM Groep Lens, Cancer, Abad, Maria Alba, Gupta, Tanmay, Hadders, Michael A, Meppelink, Amanda, Wopken, J Pepijn, Blackburn, Elizabeth, Zou, Juan, Gireesh, Anjitha, Buzuk, Lana, Kelly, David A, McHugh, Toni, Rappsilber, Juri, Lens, Susanne M A, Jeyaprakash, A Arockia, CMM Groep Lens, Cancer, Abad, Maria Alba, Gupta, Tanmay, Hadders, Michael A, Meppelink, Amanda, Wopken, J Pepijn, Blackburn, Elizabeth, Zou, Juan, Gireesh, Anjitha, Buzuk, Lana, Kelly, David A, McHugh, Toni, Rappsilber, Juri, Lens, Susanne M A, and Jeyaprakash, A Arockia

Published
2022

13. Detailed imaging and genetic analysis reveal a secondary BRAFL505H resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

Author

Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G., Ubink, Inge, Besselink, Nicolle J. M., Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F. J., Willems, Stefan M., Hadders, Michael A., Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S., Koudijs, Marco J., Cuppen, Edwin, Voest, Emile E., and Lolkema, Martijn P.

Published
2015
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16. Molecular Basis for CPC-Sgo1 Interaction: Implications for Centromere Localisation and Function of the CPC

Author

Abad, Maria Alba, primary, Gupta, Tanmay, additional, Hadders, Michael A, additional, Meppelink, Amanda, additional, Wopken, J Pepijn, additional, Blackburn, Elizabeth, additional, Zou, Juan, additional, Buzuk, Lana, additional, Kelly, David A, additional, McHugh, Toni, additional, Rappsilber, Juri, additional, Lens, Susanne M A, additional, and Jeyaprakash, A Arockia, additional

Published
2021
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17. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Author

Rehmann, Holger, Arias-Palomo, Ernesto, Hadders, Michael A., Schwede, Frank, Llorca, Oscar, and Bos, Johannes L.

Subjects
Binding proteins -- Research -- Physiological aspects -- Usage, Electron microscopy -- Usage -- Physiological aspects -- Research, Nucleotides -- Research -- Physiological aspects -- Usage, Cellular control mechanisms -- Research -- Physiological aspects -- Usage, Environmental issues, Science and technology, Zoology and wildlife conservation, Physiological aspects, Usage, Research
Abstract

Epac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins (1,2). The Epac proteins are involved in the [...]

Published
2008

18. Leave no sister behind

Author

CMM Groep Lens, Cancer, Hadders, Michael A., Lens, Susanne M.A., CMM Groep Lens, Cancer, Hadders, Michael A., and Lens, Susanne M.A.

Published
2021

19. A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis

Author

CMM Groep Lens, Cancer, Ueki, Yumi, Hadders, Michael A., Weisser, Melanie B., Nasa, Isha, Sotelo-Parrilla, Paula, Cressey, Lauren E., Gupta, Tanmay, Hertz, Emil P. T., Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. Arockia, Kettenbach, Arminja, Lens, Susanne M. A., Nilsson, Jakob, CMM Groep Lens, Cancer, Ueki, Yumi, Hadders, Michael A., Weisser, Melanie B., Nasa, Isha, Sotelo-Parrilla, Paula, Cressey, Lauren E., Gupta, Tanmay, Hertz, Emil P. T., Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. Arockia, Kettenbach, Arminja, Lens, Susanne M. A., and Nilsson, Jakob

Published
2021

23. A Newborn Falsely Suspected of Congenital Hypothyroidism due to Mutated Thyroxine-Binding Globulin with Low Binding Affinity

Author

Hengeveld, Rutger C.C., primary, Albersen, Monique, additional, Hadders, Michael A.H., additional, Hellinga, Ilse, additional, Bikker, Hennie, additional, Heijboer, Annemieke C., additional, Paul van Trotsenburg, A.S., additional, Hillebrand, Jacquelien J., additional, Boelen, Anita, additional, and Zwaveling-Soonawala, Nitash, additional

Published
2021
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24. A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

Author

Ueki, Yumi, primary, Hadders, Michael, additional, Weisser, Melanie B, additional, Nasa, Isha, additional, Gupta, Tanmay, additional, Hertz, Emil T, additional, Kruse, Thomas, additional, Montoya, Guillermo, additional, Jeyaprakash, A. Arockia, additional, Kettenbach, Arminja, additional, Lens, Susanne M.A., additional, and Nilsson, Jakob, additional

Published
2020
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26. Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis

Author

CMM Groep Lens, Cancer, Divisie Beeld & Oncologie, Hadders, Michael A., Hindriksen, Sanne, Truong, My Anh, Mhaskar, Aditya N., Pepijn Wopken, J., Vromans, Martijn J.M., Lens, Susanne M.A., CMM Groep Lens, Cancer, Divisie Beeld & Oncologie, Hadders, Michael A., Hindriksen, Sanne, Truong, My Anh, Mhaskar, Aditya N., Pepijn Wopken, J., Vromans, Martijn J.M., and Lens, Susanne M.A.

Published
2020

28. A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis.

Author

Yumi Ueki, Hadders, Michael A., Weisser, Melanie B., Nasa, Isha, Sotelo-Parrilla, Paula, Cressey, Lauren E., Gupta, Tanmay, Hertz, Emil P. T., Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. Arockia, Kettenbach, Arminja, Lens, Susanne M. A., and Nilsson, Jakob

Abstract

The shugoshin proteins are universal protectors of centromeric cohesin during mitosis and meiosis. The binding of human hSgo1 to the PP2A-B56 phosphatase through a coiled-coil (CC) region mediates cohesion protection during mitosis. Here we undertook a structure function analysis of the PP2A-B56-hSgo1 complex, revealing unanticipated aspects of complex formation and function. We establish that a highly conserved pocket on the B56 regulatory subunit is required for hSgo1 binding and cohesion protection during mitosis in human somatic cells. Consistent with this, we show that hSgo1 blocks the binding of PP2A-B56 substrates containing a canonical B56 binding motif. We find that PP2A-B56 bound to hSgo1 dephosphorylates Cdk1 sites on hSgo1 itself to modulate cohesin interactions. Collectively our work provides important insight into cohesion protection during mitosis. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

Author

Hindriksen, Sanne, Bramer, Arne J, Truong, My Anh, Vromans, Martijn J M, Post, Jasmin B, Verlaan-Klink, Ingrid, Snippert, Hugo J, Lens, Susanne M A, Hadders, Michael A, Hindriksen, Sanne, Bramer, Arne J, Truong, My Anh, Vromans, Martijn J M, Post, Jasmin B, Verlaan-Klink, Ingrid, Snippert, Hugo J, Lens, Susanne M A, and Hadders, Michael A

Published
2017

38. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

Author

CMM Groep Lens, Cancer, Divisie Beeld & Oncologie, CMM Groep Snippert, CMM Groep Bos, Hindriksen, Sanne, Bramer, Arne J, Truong, My Anh, Vromans, Martijn J M, Post, Jasmin B, Verlaan-Klink, Ingrid, Snippert, Hugo J, Lens, Susanne M A, Hadders, Michael A, CMM Groep Lens, Cancer, Divisie Beeld & Oncologie, CMM Groep Snippert, CMM Groep Bos, Hindriksen, Sanne, Bramer, Arne J, Truong, My Anh, Vromans, Martijn J M, Post, Jasmin B, Verlaan-Klink, Ingrid, Snippert, Hugo J, Lens, Susanne M A, and Hadders, Michael A

Published
2017

39. Structure-guided design of selective epac1 and epac2 agonists

Author

Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger, Sub Crystal and Structural Chemistry, Sub NMR Spectroscopy, NMR Spectroscopy, Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Crystal and Structural Chemistry, Sub NMR Spectroscopy, and NMR Spectroscopy

Subjects
Models, Molecular, medicine.medical_specialty, QH301-705.5, medicine.medical_treatment, Neuroscience(all), Plasma protein binding, Biology, Pharmacology, Crystallography, X-Ray, Research Support, Biochemistry, General Biochemistry, Genetics and Molecular Biology, Islets of Langerhans, In vivo, Internal medicine, Cell Line, Tumor, Immunology and Microbiology(all), Insulin Secretion, medicine, Cyclic AMP, Journal Article, Potency, Guanine Nucleotide Exchange Factors, Humans, Insulin, Binding site, Biology (General), Non-U.S. Gov't, Binding Sites, General Immunology and Microbiology, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), General Neuroscience, Research Support, Non-U.S. Gov't, In vitro, 3. Good health, Endocrinology, Drug Design, Second messenger system, Guanine nucleotide exchange factor, General Agricultural and Biological Sciences, Research Article, Protein Binding, Genetics and Molecular Biology(all)
Abstract

The second messenger cAMP is known to augment glucose-induced insulin secretion. However, its downstream targets in pancreatic β-cells have not been unequivocally determined. Therefore, we designed cAMP analogues by a structure-guided approach that act as Epac2-selective agonists both in vitro and in vivo. These analogues activate Epac2 about two orders of magnitude more potently than cAMP. The high potency arises from increased affinity as well as increased maximal activation. Crystallographic studies demonstrate that this is due to unique interactions. At least one of the Epac2-specific agonists, Sp-8-BnT-cAMPS (S-220), enhances glucose-induced insulin secretion in human pancreatic cells. Selective targeting of Epac2 is thus proven possible and may be an option in diabetes treatment., Author Summary cAMP is a small molecule produced by cells that activates proteins involved in a wide range of biological processes, including olfaction, pacemaker activity, regulation of gene expression, insulin secretion, and many others. In the case of insulin secretion, cAMP seems to impinge on different stages of the signalling cascade to regulate secretory activity in pancreatic β-cells. Here we have developed a chemically modified version of cAMP that specifically only activates Epac2, one of the cAMP-responsive proteins in this cascade. Furthermore, our cAMP analogue activates Epac2 more potently than cAMP itself does. We have determined several crystal structures of Epac2 in complex with cAMP analogues to help us explain the molecular basis of the observed selectivity and the strong activation potential. In addition, we were able to show that the analogue is able to potentiate glucose-induced secretion of insulin from human pancreatic islets. The principal challenge during this study was identifying and understanding small differences in the cAMP-binding domains of cAMP-regulated proteins and matching these differences with suitable modifications of the cAMP molecule., A newly developed analogue of cAMP that selectively activates Epac2 can potentiate glucose-induced insulin secretion from human pancreatic β-cells.

Published
2015

41. Structure-guided design of selective epac1 and epac2 agonists

Author

Sub Crystal and Structural Chemistry, Sub NMR Spectroscopy, NMR Spectroscopy, Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger, Sub Crystal and Structural Chemistry, Sub NMR Spectroscopy, NMR Spectroscopy, Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, and Rehmann, Holger

Published
2015

42. Detailed imaging and genetic analysis reveal a secondary BRAF(L) (505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

Author

Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G, Ubink, Inge, Besselink, Nicolle J M, Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F J, Willems, Stefan M, Hadders, Michael A, Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S, Koudijs, Marco J, Cuppen, Edwin, Voest, Emile E, Lolkema, Martijn P, Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G, Ubink, Inge, Besselink, Nicolle J M, Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F J, Willems, Stefan M, Hadders, Michael A, Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S, Koudijs, Marco J, Cuppen, Edwin, Voest, Emile E, and Lolkema, Martijn P

Abstract

Resistance to treatment is the main problem of targeted treatment for cancer. We followed ten patients during treatment with vemurafenib, by three-dimensional imaging. In all patients, only a subset of lesions progressed. Next-generation DNA sequencing was performed on sequential biopsies in four patients to uncover mechanisms of resistance. In two patients, we identified mutations that explained resistance to vemurafenib; one of these patients had a secondary BRAF L505H mutation. This is the first observation of a secondary BRAF mutation in a vemurafenib-resistant patient-derived melanoma sample, which confirms the potential importance of the BRAF L505H mutation in the development of therapy resistance. Moreover, this study hints toward an important role for tumor heterogeneity in determining the outcome of targeted treatments.

Published
2015

44. Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores

Author

CMM Groep Maurice, Cancer, CMM Sectie Molecular Cancer Research, Divisie Beeld & Oncologie, CMM Groep Lens, CMM USEQ Facility, Vleugel, Mathijs, Omerzu, Manja, Groenewold, Vincent, Hadders, Michael A, Lens, Susanne M A, Kops, Geert J P L, CMM Groep Maurice, Cancer, CMM Sectie Molecular Cancer Research, Divisie Beeld & Oncologie, CMM Groep Lens, CMM USEQ Facility, Vleugel, Mathijs, Omerzu, Manja, Groenewold, Vincent, Hadders, Michael A, Lens, Susanne M A, and Kops, Geert J P L

Published
2015

45. Structure-Guided Design of Selective Epac1 and Epac2 Agonists

Author

Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, CMM Groep Bos, Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N., Hadders, Michael A., Wienk, Hans, Ellenbroek, Johanne H., de Koning, Eelco J P, Bos, Johannes L., Herberg, Friedrich W., Genieser, Hans Gottfried, Janssen, Richard A J, Rehmann, Holger, Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, CMM Groep Bos, Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N., Hadders, Michael A., Wienk, Hans, Ellenbroek, Johanne H., de Koning, Eelco J P, Bos, Johannes L., Herberg, Friedrich W., Genieser, Hans Gottfried, Janssen, Richard A J, and Rehmann, Holger

Published
2015

46. Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

Author

Arts-assistenten Radiotherapie, MS CGO, CMM Groep Kloosterman, MS Radiologie, Cancer, Circulatory Health, Researchgr. Beeldg. Moleculaire Interv., Pathologie Pathologen staf, Other research (not in main researchprogram), CMM Groep Lens, Genetica Sectie Genoomdiagnostiek, CMM Sectie Genomics and Bioinformatics, Hubrecht Institute with UMC, Child Health, Externen Med. Onco, Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G., Ubink, Inge, Besselink, Nicolle J. M., Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F. J., Willems, Stefan M., Hadders, Michael A., Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S., Koudijs, Marco J., Cuppen, Edwin, Voest, Emile E., Lolkema, Martijn P., Arts-assistenten Radiotherapie, MS CGO, CMM Groep Kloosterman, MS Radiologie, Cancer, Circulatory Health, Researchgr. Beeldg. Moleculaire Interv., Pathologie Pathologen staf, Other research (not in main researchprogram), CMM Groep Lens, Genetica Sectie Genoomdiagnostiek, CMM Sectie Genomics and Bioinformatics, Hubrecht Institute with UMC, Child Health, Externen Med. Onco, Hoogstraat, Marlous, Gadellaa-van Hooijdonk, Christa G., Ubink, Inge, Besselink, Nicolle J. M., Pieterse, Mark, Veldhuis, Wouter, van Stralen, Marijn, Meijer, Eelco F. J., Willems, Stefan M., Hadders, Michael A., Kuilman, Thomas, Krijgsman, Oscar, Peeper, Daniel S., Koudijs, Marco J., Cuppen, Edwin, Voest, Emile E., and Lolkema, Martijn P.

Published
2015

47. Detailed imaging and genetic analysis reveal a secondaryBRAFL505Hresistance mutation and extensive intrapatient heterogeneity in metastaticBRAFmutant melanoma patients treated with vemurafenib

Author

Hoogstraat, Marlous, primary, Gadellaa-van Hooijdonk, Christa G., additional, Ubink, Inge, additional, Besselink, Nicolle J. M., additional, Pieterse, Mark, additional, Veldhuis, Wouter, additional, van Stralen, Marijn, additional, Meijer, Eelco F. J., additional, Willems, Stefan M., additional, Hadders, Michael A., additional, Kuilman, Thomas, additional, Krijgsman, Oscar, additional, Peeper, Daniel S., additional, Koudijs, Marco J., additional, Cuppen, Edwin, additional, Voest, Emile E., additional, and Lolkema, Martijn P., additional

Published
2015
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