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8 results on '"Hackl, Carmen M."'

5. Synthesis and in vivo anticancer evaluation of poly(organo)phosphazene-based metallodrug conjugates

Author

Hackl, Carmen M., primary, Schoenhacker-Alte, Beatrix, additional, Klose, Matthias H. M., additional, Henke, Helena, additional, Legina, Maria S., additional, Jakupec, Michael A., additional, Berger, Walter, additional, Keppler, Bernhard K., additional, Brüggemann, Oliver, additional, Teasdale, Ian, additional, Heffeter, Petra, additional, and Kandioller, Wolfgang, additional

Published
2017
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6. Thiomaltol‐Based Organometallic Complexes with 1‐Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior

Author

Hackl, Carmen M., primary, Legina, Maria S., additional, Pichler, Verena, additional, Schmidlehner, Melanie, additional, Roller, Alexander, additional, Dömötör, Orsolya, additional, Enyedy, Eva A., additional, Jakupec, Michael A., additional, Kandioller, Wolfgang, additional, and Keppler, Bernhard K., additional

Published
2016
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8. Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior.

Author

Hackl CM, Legina MS, Pichler V, Schmidlehner M, Roller A, Dömötör O, Enyedy EA, Jakupec MA, Kandioller W, and Keppler BK

Subjects
Humans, Magnetic Resonance Spectroscopy, X-Ray Diffraction, Imidazoles chemistry, Organometallic Compounds chemistry, Pyrans chemistry, Thiones chemistry
Abstract

Thiomaltol, a potential S,O-coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired Ru II , Os II , Rh III , and Ir III complexes having a "piano-stool" configuration. In addition to the synthesis of these compounds with a chlorido leaving group, the analogous 1-methylimidazole derivatives have been prepared, giving rise to thiomaltol-based organometallics with enhanced stability under physiological conditions. The organometallic compounds have been characterized by NMR spectroscopy, elemental analysis, and X-ray diffraction analysis. Their behavior in aqueous solution and their interactions with certain amino acids have been studied by ESI mass spectrometry. Their pH-dependent stability has been investigated by 1 H NMR in aqueous solution, and their cytotoxicity against three different cancer cell lines has been investigated. Furthermore, their capacity as topoisomerase IIα inhibitors as well as their effect on the cell cycle distribution and reactive oxygen species (ROS) generation have been elucidated., (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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