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1. 10Be chronology of deglaciation and ice-dammed lake regression in the vicinity of the Mylodon Cave (Cerro Benítez, Patagonia, Chile)

Author: Igor Girault, Dominique Todisco, Attila Çiner, Mehmet Akif Sarıkaya, Cengiz Yıldırım, Amélie Quiquerez, Fabiana Martin, Luis Borrero, Derek Fabel, Philippe Grandjean, Carole Nehme, Damase Mouralis, Institut des Sciences de la Terre (ISTerre), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel-Université Grenoble Alpes (UGA), Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés (IDEES), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département de géologie, Département de géologie, Université Hacettepe, Beytepe, Hacettepe University = Hacettepe Üniversitesi-Hacettepe University = Hacettepe Üniversitesi, Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Ministère de la Culture et de la Communication (MCC), Centro de Estudios del Hombre Austral, Universidad de Magallanes (UMAG), University of Glasgow, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Eurasia Institute of Earth Sciences, Istanbul Technical University, Turkey, Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Instituto Multidisciplinario de Historia y Ciencias Humanas, CONICET, Universidad de Buenos Aires, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Pleistocene, Mylodon Cave, Archeology, Global and Planetary Change, Glaciation, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Cosmogenic isotopes, Glacial Chronological modelling, Geology, Geomorphology, South America, Ecology, Evolution, Behavior and Systematics
Abstract: International audience; Located 51.5°S in the vicinity of the Southern Patagonian Ice Field, Cerro Benítez and the glacial valley of Lago Sofía host several caves and rock shelters that were occupied by megafauna and humans during the Late Pleistocene, including the Mylodon Cave and two of the oldest archaeological sites in Patagonia. During the last glaciation, Cerro Benítez was alternately covered by the Patagonian Ice Sheet and surrounded by an ice-dammed lake which restricted the access to the caves and rock shelters located under its uppermost level, 155 m a.s.l. This study aims to provide a detailed chronology of the deglaciation and lake regression in Cerro Benítez. The glacial fluctuations and the variations of lake level were reconstructed from multi-scale, remote-sensing data and field geomorphological mapping. In addition, we calculated the surface exposure age of 11 erratic blocks located above and on the lacustrine erosional platform using terrestrial cosmogenic 10Be in order to date ice downwasting and lake regression, respectively. Dates of ice downwasting and lake regression events were modelled from prior surface exposure ages using Bayesian statistics. The results suggest that the Patagonian Ice Sheet locally thinned by at least 300 m during MIS 3 in the aftermath of a major glacial advance. Following deglaciation, the ice-dammed lake experienced a slow local regression (ca. 2.5 mm. a−1) until 16.9 ka B2k, interpreted as the result of lake basin tilting due to differential post-glacial isostatic rebound. This initial phase of lake regression was followed by a faster regression caused by the reversal of the lake drainage between 16.9 and 15.4 ka B2k. We assess the chronological model by comparison with uplift and lakeshore erosion rates from the literature and eventually discuss the implications for megafaunal colonisation of the area.
Published: 2022

2. First archive of extensive N-fixation by volcanic lightning and implications for the prebiotic Earth

Author: Adeline Aroskay, Erwan Martin, Slimane Bekki, Joël Savarino, Jean-Luc Le Pennec, Abidin Temel, Nelida Manrique, Rigoberto Aguilar, Marco Rivera, Sophie Szopa, Institut des Sciences de la Terre de Paris (iSTeP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), STRATO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Hacettepe University = Hacettepe Üniversitesi, Instituto Geológico Minero y Metalúrgico (INGEMMET), Instituto Geofísico del Perú (IGP), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.STU.VO]Sciences of the Universe [physics]/Earth Sciences/Volcanology
Abstract: On Earth, most of the nitrogen (N) accessible for life is trapped in dinitrogen (N2), which is the most stable atmospheric molecule. In order to be metabolised by living organisms, N2 has to be converted into assimilable forms, also called fixed N. Nowadays, nearly all the N-fixation is achieved through biological and anthropogenic processes. However, in early environments of the Earth, before the emergence of life, N-fixation must have occurred via natural abiotic processes. Electrical discharges, including from thunderstorms and also lightning associated with volcanic eruptions is one of the most invoked processes. The occurence of volcanic lightning during explosive eruptions is frequent, and convincing laboratory experimentations support the role of this phenomenon, however no evidence of substantial N-fixation has been found in volcanic records. Here we report on the discovery of large amounts of nitrates in volcanic deposits from Neogene caldera-forming eruptions, which are well correlated with the concentrations of species directly emitted by volcanoes such as sulphur and chlorine. The multi-isotopic composition (δ18O, Δ17O) of the nitrates reveals that they originate from the atmospheric oxidation of nitrogen oxides formed by volcanic lightning that occur during the eruption. According to these volcanic nitrate records, our first estimates suggest that about 60 Tg of N can be fixed during a large explosive event. Our findings hint at a unique role potentially played by subaerial explosive eruptions in supplying essential ingredients for the emergence of life on Earth.
Published: 2023

3. Approach to optimal assessment of right ventricular remodelling in heart transplant recipients: insights from myocardial work index, T1 mapping, and endomyocardial biopsy

Author: Leyla Elif Sade, Ayse Colak, Selin Ardali Duzgun, Tuncay Hazırolan, Atilla Sezgin, Erwan Donal, Steele C Butcher, Handan Özdemir, Bahar Pirat, Serpil Eroglu, Haldun Muderrisoglu, Başkent University Hospital [Adana, Turkey], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Hacettepe University = Hacettepe Üniversitesi, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universiteit Leiden, and University of Baskent
Subjects: strain, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Radiology, Nuclear Medicine and imaging, General Medicine, right ventricle, T1 mapping, heart transplantation, Cardiology and Cardiovascular Medicine, cardiac magnetic resonance, myocardial work
Abstract: Aims Right ventricular (RV) dysfunction is an important cause of graft failure after heart transplantation (HTx). We sought to investigate relative merits of echocardiographic tools and cardiac magnetic resonance (CMR) with T1 mapping for the assessment of functional adaptation and remodelling of the RV in HTx recipients. Methods and results Sixty-one complete data set of echocardiography, CMR, right heart catheterization, and biopsy were obtained. Myocardial work index (MWI) was quantified by integrating longitudinal strain (LS) with invasively measured pulmonary artery pressure. CMR derived RV volumes, T1 time, and extracellular volume (ECV) were quantified. Endomyocardial biopsy findings were used as the reference standard for myocardial microstructural changes. In HTx recipients who never had a previous allograft rejection, longitudinal function parameters were lower than healthy organ donors, while ejection fraction (EF) (52.0 ± 8.7%) and MWI (403.2 ± 77.2 mmHg%) were preserved. Rejection was characterized by significantly reduced LS, MWI, longer T1 time, and increased ECV that improved after recovery, whereas RV volumes and EF did not change MWI was the strongest determinant of rejection related myocardial damage (area under curve: 0.812, P < 0.0001, 95% CI: 0.69–0.94) with good specificity (77%), albeit modest sensitivity. In contrast, T1 time and ECV were sensitive (84%, both) but not specific to detect subclinical RV damage. Conclusion Subclinical adaptive RV remodelling is characterized by preserved RV EF despite longitudinal function abnormalities, except for MWI. While ultrastructural damage is reflected by MWI, ECV, and T1 time, only MWI has the capability to discriminate functional adaptation from transition to subclinical structural damage.
Published: 2022

4. Phase II study of afatinib plus pembrolizumab in patients with squamous cell carcinoma of the lung following progression during or after first-line chemotherapy (LUX-Lung-IO)

Author: Benjamin Levy, Fabrice Barlesi, Luis Paz-Ares, Jaafar Bennouna, Mustafa Erman, Enriqueta Felip, Dolores Isla, Hye Ryun Kim, Sang-We Kim, Jeannick Madelaine, Olivier Molinier, Mustafa Özgüroğlu, Delvys Rodríguez Abreu, Abidemi Adeniji, Robert M. Lorence, Isabelle Voccia, Michael J. Chisamore, Jonathan W. Riess, Institut Català de la Salut, [Levy B] Johns Hopkins Sidney Kimmel Cancer Center at Sibley Memorial Hospital, Washington, DC, USA. [Barlesi F] Aix Marseille University, CNRS, INSERM, CRCM, Assistance Publique Hôpitaux de Marseille, Marseille, France. Gustave Roussy Cancer Campus, Villejuif, France. [Paz-Ares L] Department of Medical Oncology, University Hospital 12 De Octubre, Madrid, Spain. [Bennouna J] Department of Pneumology, Thoracic Oncology, University Hospital - Nantes, Nantes, France. [Erman M] Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey. [Felip E] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Isla D] Department of Medical Oncology, University Hospital Lozano Blesa, Zaragoza, Spain, Vall d'Hebron Barcelona Hospital Campus, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Hôpital Foch [Suresnes], Hacettepe University = Hacettepe Üniversitesi, Vall d'Hebron University Hospital [Barcelona], Yonsei University College of Medicine [Séoul, Corée du Sud], Service de pneumologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), and Centre Hospitalier Le Mans (CH Le Mans)
Subjects: Male, Pulmonary and Respiratory Medicine, Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms [DISEASES], Cancer Research, Lung Neoplasms, [SDV]Life Sciences [q-bio], Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Middle Aged, Afatinib, Antibodies, Monoclonal, Humanized, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Quimioteràpia combinada, ErbB Receptors, neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares [ENFERMEDADES], Oncology, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Avaluació de resultats (Assistència sanitària), Humans, Female, Pulmons - Càncer - Tractament
Abstract: Afatinib; Carcinoma, Squamous Cell; Pembrolizumab Afatinib; Carcinoma de células escamosas; Pembrolizumab Afatinib; Carcinoma de cèl·lules escamoses; Pembrolizumab Introduction Afatinib and pembrolizumab have separately shown survival benefit in patients with squamous cell carcinoma (SqCC) of the lung, and there is biological rationale for concurrent inhibition of the programmed death ligand-1 and epidermal growth factor receptor (EGFR) pathways in this patient population. Materials and Methods This open-label, single-arm study enrolled patients with SqCC of the lung who had progressed during/after first-line chemotherapy and comprised two parts: a safety run-in to establish the recommended phase II dose (RP2D; afatinib 40 mg or 30 mg once daily with pembrolizumab 200 mg every 3 weeks); and the main part assessing efficacy and safety of the RP2D. The primary endpoint was objective response rate (ORR); secondary endpoints included the RP2D, progression-free survival (PFS) and overall survival (OS). Results Twenty-four patients were treated in the safety run-in (afatinib 40 mg/30 mg cohorts: n = 12/12). Median age was 63.5 years; 79.2% of patients were male. All patients discontinued afatinib and pembrolizumab, most commonly due to disease progression (58.3% and 75.0%, respectively) or adverse events (AEs; 37.5% and 25.0%, respectively). The study was discontinued early after completion of the safety run-in, and no patients entered the main part. ORR was 12.5%; median PFS and OS were 13.1 and 29.3 weeks, respectively. All patients had ≥ 1 drug-related AE (grade ≥ 3: 45.8%). Conclusion While there were no new or unexpected safety findings, exploratory analysis of antitumor activity indicated limited efficacy with afatinib plus pembrolizumab in patients with SqCC of the lung who had progressed during/after first-line chemotherapy. This work was supported by Boehringer Ingelheim International GmbH and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Both study sponsors participated in the design of the study, the collection, analysis, and interpretation of the data, writing this article, and the decision to submit the article for publication.
Published: 2022

5. Diagnostic workup of childhood interstitial lung disease

Author: Nathan, Nadia, Griese, Matthias, Michel, Katarzyna, Carlens, Julia, Gilbert, Carlee, Emiralioglu, Nagehan, Torrent-Vernetta, Alba, Marczak, Honorata, Willemse, Brigitte, Delestrain, Céline, Epaud, Ralph, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Nathan N] AP-HP, Sorbonne Université, Pediatric Pulmonology Department and Reference Center for Rare Lung Disease RespiRare, Armand Trousseau Hospital, Paris, France. Sorbonne Université, Inserm Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, Paris, France. [Griese M, Michel K] Department of Paediatric Pneumology, Dr von Hauner Children’s Hospital, German Centre for Lung Research, University of Munich, Munich, Germany. [Carlens J] Clinic for Pediatric Pneumology, Hannover Medical School, Hannover, Germany. [Gilbert C] Institute of Population Health, University of Liverpool, Liverpool, UK. [Emiralioglu N] Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. [Torrent-Vernetta A] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus, Service de Pneumologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de référence national pour les maladies respiratoires rares de l’enfant RespiRare [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Trousseau [APHP], Maladies génétiques d'expression pédiatrique [CHU Trousseau] (Inserm U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Hannover Medical School [Hannover] (MHH), University of Liverpool, Hacettepe University = Hacettepe Üniversitesi, Faculty of Medicine [Hacettepe University], Universitat Autònoma de Barcelona (UAB), CIBER de Enfermedades Raras (CIBERER), Medical University of Warsaw - Poland, University of Groningen [Groningen], Centre Hospitalier Intercommunal de Créteil (CHIC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Couvet, Sandrine
Subjects: Pulmonary and Respiratory Medicine, Rentada broncoalveolar, técnicas de investigación::irrigación terapéutica::lavado broncoalveolar [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial [DISEASES], diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Otros calificadores::/diagnóstico [Otros calificadores], Investigative Techniques::Therapeutic Irrigation::Bronchoalveolar Lavage [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], personas::Grupos de Edad::niño [DENOMINACIONES DE GRUPOS], Persons::Age Groups::Child [NAMED GROUPS], [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales [ENFERMEDADES], Pulmons - Càncer - Diagnòstic, Other subheadings::/diagnosis [Other subheadings], [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Infants, Imatgeria per al diagnòstic
Abstract: Childhood interstitial lung diseases (chILDs) are rare and heterogeneous diseases with significant morbidity and mortality. An accurate and quick aetiological diagnosis may contribute to better management and personalised treatment. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review summarises the roles of the general paediatrician, paediatric pulmonologists and expert centres in the complex diagnostic workup. Each patient's aetiological chILD diagnosis must be reached without prolonged delays in a stepwise approach from medical history, signs, symptoms, clinical tests and imaging, to advanced genetic analysis and specialised procedures including bronchoalveolar lavage and biopsy, if necessary. Finally, as medical progress is fast, the need to revisit a diagnosis of "undefined chILD" is stressed. Childhood interstitial lung diseases are rare and severe diseases. A stepwise approach to an aetiological diagnosis includes specific investigations performed in expert centres. The term "undefined chILD" must be regularly reassessed
Published: 2023

6. LAPTNet-FPN: Multi-scale LiDAR-aided Projective Transform Network for Real Time Semantic Grid Prediction

Author: Diaz-Zapata, Manuel Alejandro, González, David Sierra, Erkent, Özgür, Dibangoye, Jilles, Laugier, Christian, Robots coopératifs et adaptés à la présence humaine en environnements (CHROMA), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-CITI Centre of Innovation in Telecommunications and Integration of services (CITI), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Hacettepe University = Hacettepe Üniversitesi, Toyota Motor Europe, IEEE Robotics and Automation Society, and Grid'5000
Subjects: sensor fusion, FOS: Computer and information sciences, Computer Science - Artificial Intelligence, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], robotic perception, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], Computer Science - Robotics, Artificial Intelligence (cs.AI), [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], semantic grids, artificial neural networks, Robotics (cs.RO)
Abstract: Semantic grids can be useful representations of the scene around an autonomous system. By having information about the layout of the space around itself, a robot can leverage this type of representation for crucial tasks such as navigation or tracking. By fusing information from multiple sensors, robustness can be increased and the computational load for the task can be lowered, achieving real time performance. Our multi-scale LiDAR-Aided Perspective Transform network uses information available in point clouds to guide the projection of image features to a top-view representation, resulting in a relative improvement in the state of the art for semantic grid generation for human (+8.67%) and movable object (+49.07%) classes in the nuScenes dataset, as well as achieving results close to the state of the art for the vehicle, drivable area and walkway classes, while performing inference at 25 FPS., Comment: 2023 IEEE International Conference on Robotics and Automation (ICRA), IEEE Robotics and Automation Society, May 2023, London, United Kingdom
Published: 2023
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7. Diagnostic stewardship in infectious diseases: a continuum of antimicrobial stewardship in the fight against antimicrobial resistance

Author: Johnny Zakhour, Sara F Haddad, Anthony Kerbage, Heiman Wertheim, Pierre Tattevin, Andreas Voss, Serhat Ünal, Abdoul Salam Ouedraogo, Souha S Kanj, American University of Beirut Faculty of Medicine and Medical Center (AUB), Mayo Clinic [Rochester], Radboud University Medical Center [Nijmegen], CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University Medical Center Groningen [Groningen] (UMCG), Faculty of Medicine [Hacettepe University], and Hacettepe University = Hacettepe Üniversitesi
Subjects: Microbiology (medical), All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Pharmacology (medical), Novel diagnostics in Infectious Diseases, General Medicine, Antimicrobial stewardship, Multidisciplinary teams, Diagnostic stewardship
Abstract: Contains fulltext : 293869.pdf (Publisher’s version ) (Open Access) Antimicrobial resistance (AMR) has been exacerbated by the inappropriate use of diagnostics, leading to excessive prescription of antimicrobials, and is an imminent threat to global health. Diagnostic stewardship (DS) is an auxiliary to antimicrobial stewardship (AMS) and comprises ordering the right tests, for the right patient, at the right time. It also promotes the judicious use of rapid and novel molecular diagnostic tools to enable the initiation of proper antibiotic therapy, while avoiding excessive use of broad-spectrum antibiotics. Proper interpretation of test results is crucial to avoid overdiagnosis and excessive healthcare costs. Although many rapid diagnostic tools have been developed with a high diagnostic yield, they are often limited by accessibility, cost, and lack of knowledge regarding their use. Careful consideration of clinical signs and symptoms with knowledge of the local epidemiology are essential for DS. This enables appropriate interpretation of microbiological results. Multidisciplinary teams that include well trained professionals should cooperate to promote DS. Challenges and barriers to the implementation of DS are mostly caused by scarcity of resources and lack of trained personnel and, most importantly, lack of knowledge. The lack of resources is often due to absence of awareness of the impact that good medical microbiology diagnostic facilities and expertise can have on the proper use of antibiotics. 01 juli 2023
Published: 2023

8. Democratizing knowledge representation with BioCypher

Author: Lobentanzer, Sebastian, Aloy, Patrick, Baumbach, Jan, Bohar, Balazs, Charoentong, Pornpimol, Danhauser, Katharina, Doğan, Tunca, Dreo, Johann, Dunham, Ian, Fernandez-Torras, Adrià, Gyori, Benjamin, Hartung, Michael, Hoyt, Charles Tapley, Klein, Christoph, Korcsmaros, Tamas, Maier, Andreas, Mann, Matthias, Ochoa, David, Pareja-Lorente, Elena, Preusse, Martin, Probul, Niklas, Schwikowski, Benno, Sen, Bünyamin, Strauss, Maximilian, Turei, Denes, Ulusoy, Erva, Wodke, Judith, Waltemath, Dagmar, Saez-Rodriguez, Julio, Carey, Vincent, Farr, Elias, Popp, Ferdinand, Universität Heidelberg [Heidelberg] = Heidelberg University, Institute for Research in Biomedicine [Barcelona, Spain] (IRB), University of Barcelona-Barcelona Institute of Science and Technology (BIST), University of Hamburg, Earlham Institute [Norwich], Biological Research Centre [Szeged] (BRC), Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Hacettepe University = Hacettepe Üniversitesi, Biomédecine computationelle des systèmes / Computational systems biomedicine, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Harvard Medical School [Boston] (HMS), Dr Von Hauner Children's Hospital, Partenaires INRAE, Quadram Institute Bioscience [Norwich, U.K.] (QIB), Biotechnology and Biological Sciences Research Council (BBSRC), Imperial College London, Universität zu Köln = University of Cologne, Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry (MPIB), Max-Planck-Gesellschaft, German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), University of Medicine Greifswald, Brigham & Women’s Hospital [Boston] (BWH), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), European Project: 965193, H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being H2020-EU.3.1.5. - Methods and data ,DECIDER(2021), European Project: 066490,WT::(2003), European Project: 031L0181B,LaMarck, European Project: 031L0212A,SMART-CARE, European Project: W911NF-20-1-0255, and European Project: 01ZZ2019,MIRACUM
Subjects: prior knowledge, knowledge graph, federated learning, harmonisation, FAIRness, ontology, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], database
Abstract: International audience; Standardising the representation of biomedical knowledge among allresearchers is an insurmountable task, hindering the effectiveness of manycomputational methods. To facilitate harmonisation and interoperability despitethis fundamental challenge, we propose to standardise the framework ofknowledge graph creation instead. We implement this standardisation inBioCypher, a FAIR (findable, accessible, interoperable, reusable) framework totransparently build biomedical knowledge graphs while preserving provenances ofthe source data. Mapping the knowledge onto biomedical ontologies helps tobalance the needs for harmonisation, human and machine readability, and ease ofuse and accessibility to non-specialist researchers. We demonstrate the usefulnessof the framework on a variety of use cases, from maintenance of task-specificknowledge stores, to interoperability between biomedical domains, to on-demandbuilding of task-specific knowledge graphs for federated learning. BioCypher(https://biocypher.org) thus facilitates automating knowledge-based biomedicalresearch, and we encourage the community to further develop and use it.
Published: 2023

9. The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats

Author: Alain Favier, Belma Kocer-Gumusel, Josiane Arnaud, Filiz Hincal, Pinar Erkekoglu, Walid Rachidi, Department of Toxicology, Faculty of Pharmacy-Hacettepe University = Hacettepe Üniversitesi, Biochimie Hormonale et Nutritionnelle, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Hacettepe University = Hacettepe Üniversitesi-Faculty of Pharmacy, Département de biologie intégrée, CHU Grenoble-Hôpital Michallon, SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de biologie du stress oxydant, Université Joseph Fourier - Grenoble 1 (UJF), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), and Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Antioxidant, medicine.medical_treatment, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], 010501 environmental sciences, Kidney, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Selenium deficiency, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Testis, Tissue Distribution, Germ-Cell Apoptosis, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], 0303 health sciences, Phthalate, 3. Good health, medicine.anatomical_structure, Liver, Organ Specificity, Toxicity, Trace element, Molecular Medicine, Reproductive toxicity, medicine.medical_specialty, endocrine system, chemistry.chemical_element, [SDV.CAN]Life Sciences [q-bio]/Cancer, Exposure, Inorganic Chemistry, Selenium, 03 medical and health sciences, Dietary Zinc, Selenium supplementation, Diethylhexyl Phthalate, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Internal medicine, medicine, Animals, Di-(2-Ethylhexyl) Phthalate, Mono-(2-Ethylhexyl) Phthalate, Testicular Atrophy, 030304 developmental biology, 0105 earth and related environmental sciences, Testicular atrophy, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, medicine.disease, Rats, Trace Elements, Oxidative Stress, Endocrinology, chemistry, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract: International audience; Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer for synthetic polymers, is known to have endocrine disruptive potential, reproductive toxicity, and induces hepatic carcinogenesis in rodents. Selenium (Se) is a component of several selenoenzymes which are essential for cellular antioxidant defense and for the functions of mammalian reproductive system. The present study was designed to investigate the effects of DEHP exposure on trace element distribution in liver, testis, and kidney tissues and plasma of Se-deficient and Se-supplemented rats. Se deficiency was produced by feeding 3-week old Sprague-Dawley rats with
Published: 2015

10. ESPEN guideline on hospital nutrition

Author: Stephan C. Bischoff, Elisabet Rothenberg, M. Vaillant, Ulla Siljamäki-Ojansuu, Elina Ioannou, Karen Ottens-Oussoren, Osman Abbasoglu, Laila Meija, Ronan Thibault, Diana Rubin, Claude Pichard, CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service d'endocrinologie diabétologie et nutrition [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Anne-de-Bretagne, Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Limassol General Hospital, Riga Stradins University (RSU), VU University Medical Center [Amsterdam], Hôpitaux Universitaires de Genève (HUG), Kristianstad University College - HKR (SWEDEN), Tampere University Hospital, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, University of Hohenheim, This guideline was solely financed by ESPEN, the European Society for Clinical Nutrition and Metabolism., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Rennes (UR)-CHU Pontchaillou [Rennes]-Hôpital Anne-de-Bretagne
Subjects: medicine.medical_specialty, Monitoring, [SDV]Life Sciences [q-bio], Acute care, Clinical nutrition, Critical Care and Intensive Care Medicine, 03 medical and health sciences, Patient safety, 0302 clinical medicine, Intolerances, Food intake, medicine, 030212 general & internal medicine, Medical prescription, ddc:616, 2. Zero hunger, Nutrition and Dietetics, business.industry, Malnutrition, Guideline, Diets, medicine.disease, Obesity, 3. Good health, Family medicine, 030211 gastroenterology & hepatology, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: International audience; In hospitals through Europe and worldwide, the practices regarding hospital diets are very heterogeneous. Hospital diets are rarely prescribed by physicians, and sometimes the choices of diets are based on arbitrary reasons. Often prescriptions are made independently from the evaluation of nutritional status, and without taking into account the nutritional status. Therapeutic diets (low salt, gluten-free, texture and consistency modified, …) are associated with decreased energy delivery (i.e. underfeeding) and increased risk of malnutrition. The European Society for Clinical Nutrition and Metabolism (ESPEN) proposes here evidence-based recommendations regarding the organization of food catering, the prescriptions and indications of diets, as well as monitoring of food intake at hospital, rehabilitation center, and nursing home, all of these by taking into account the patient perspectives. We propose a systematic approach to adapt the hospital food to the nutritional status and potential food allergy or intolerances. Particular conditions such as patients with dysphagia, older patients, gastrointestinal diseases, abdominal surgery, diabetes, and obesity, are discussed to guide the practitioner toward the best evidence based therapy. The terminology of the different useful diets is defined. The general objectives are to increase the awareness of physicians, dietitians, nurses, kitchen managers, and stakeholders towards the pivotal role of hospital food in hospital care, to contribute to patient safety within nutritional care, to improve coverage of nutritional needs by hospital food, and reduce the risk of malnutrition and its related complications.
Published: 2021

11. TransFuseGrid: Transformer-based Lidar-RGB fusion for semantic grid prediction

Author: Gustavo Salazar-Gomez, David Sierra-Gonzalez, Manuel Diaz-Zapata, Anshul Paigwar, Wenqian Liu, Ozgur Erkent, Christian Laugier, Robots coopératifs et adaptés à la présence humaine en environnements (CHROMA), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-CITI Centre of Innovation in Telecommunications and Integration of services (CITI), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Université Grenoble Alpes (UGA), Université de Lyon-Institut National des Sciences Appliquées (INSA), and Hacettepe University = Hacettepe Üniversitesi
Subjects: [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; Semantic grids are a succinct and convenient approach to represent the environment for mobile robotics and autonomous driving applications. While the use of Lidar sensors is now generalized in robotics, most semantic grid prediction approaches in the literature focus only on RGB data. In this paper, we present an approach for semantic grid prediction that uses a transformer architecture to fuse Lidar sensor data with RGB images from multiple cameras. Our proposed method, TransFuseGrid, first transforms both input streams into topview embeddings, and then fuses these embeddings at multiple scales with Transformers. Finally, a decoder transforms the fused, top-view feature map into a semantic grid of the vehicle's environment. We evaluate the performance of our approach on the nuScenes dataset for the vehicle, drivable area, lane divider and walkway segmentation tasks. The results show that Trans-FuseGrid achieves superior performance than competing RGBonly and Lidar-only methods. Additionally, the Transformer feature fusion leads to a significative improvement over naive RGB-Lidar concatenation. In particular, for the segmentation of vehicles, our model outperforms state-of-the-art RGB-only and Lidar-only methods by 24% and 53%, respectively.
Published: 2022

12. LAPTNet: LiDAR-Aided Perspective Transform Network

Author: Diaz-Zapata, Manuel Alejandro, Erkent, Özgür, Laugier, Christian, Dibangoye, Jilles, Sierra González, David, Robots coopératifs et adaptés à la présence humaine en environnements (CHROMA), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-CITI Centre of Innovation in Telecommunications and Integration of services (CITI), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Hacettepe University = Hacettepe Üniversitesi, CPS4EU - Cyberphysical Systems for the European Union, TME - Toyota Motor Europe, Grid'5000, and European Project: CPS4EU
Subjects: FOS: Computer and information sciences, Computer Science - Robotics, Artificial Intelligence (cs.AI), Computer Science - Artificial Intelligence, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], Robotics (cs.RO), [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: Semantic grids are a useful representation of the environment around a robot. They can be used in autonomous vehicles to concisely represent the scene around the car, capturing vital information for downstream tasks like navigation or collision assessment. Information from different sensors can be used to generate these grids. Some methods rely only on RGB images, whereas others choose to incorporate information from other sensors, such as radar or LiDAR. In this paper, we present an architecture that fuses LiDAR and camera information to generate semantic grids. By using the 3D information from a LiDAR point cloud, the LiDAR-Aided Perspective Transform Network (LAPTNet) is able to associate features in the camera plane to the bird's eye view without having to predict any depth information about the scene. Compared to state-of-theart camera-only methods, LAPTNet achieves an improvement of up to 8.8 points (or 38.13%) over state-of-art competing approaches for the classes proposed in the NuScenes dataset validation split., ICARCV 2022 - 17th International Conference on Control, Automation, Robotics and Vision, Dec 2022, Singapore, Singapore
Published: 2022

13. Environmental and bioclimatic factors influencing yeasts and molds distribution along European shores

Author: Cogliati, M., Arikan-Akdagli, S., Barac, A., Bostanaru, A. C., Brito, S., Çerikçioğlu, N., Efstratiou, M. A., Ergin, Ç., Esposto, M. C., Frenkel, M., Gangneux, J. P., Gitto, A., Gonçalves, C. I., Guegan, H., Gunde-Cimerman, N., Güran, M., Jonikaitė, E., Kataržytė, M., Klingspor, L., Mares, M., Meijer, W. G., Melchers, W. J. G., Meletiadis, J., Nastasa, V., Babič, M. Novak, Ogunc, D., Ozhak, B., Prigitano, A., Ranque, S., Romanò, L., Rusu, R. O., Sabino, Raquel Filipa Pinheiro, Sampaio, A., Silva, S., Stephens, J. H., Tehupeiory-Kooreman, M., Velegraki, A., Veríssimo, Cristina, Segal, E., Brandão, J., Università degli Studi di Milano = University of Milan (UNIMI), Hacettepe University = Hacettepe Üniversitesi, University of Belgrade [Belgrade], Universitatea de Ştiinţe Agricole şi Medicină Veterinară 'Ion Ionescu de la Brad' - University of life sciences [Iasi, Romania], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Harokopio University of Athens, Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Tel Aviv University (TAU), Universidade de Lisboa = University of Lisbon (ULISBOA), Ana Sampaio thanks to the Foundation for Science and Technology and FEDER under Programe PT2020 for financial support to CITAB (UID/AGR/04033/2020)., and Repositório da Universidade de Lisboa
Subjects: Precipitation (chemical), Settore MED/42 - Igiene Generale e Applicata, river, yeast, Molds, Spatial distribution modelling, Soil, Sand, environmental factor, Yeasts, Distribution models, Soil Pollutants, Waste Management and Disposal, Candida, Spatial distribution modeling, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Mycosands, Modeling approach, concentration (composition), pH, Pollution, Species distribution modeling, Web database, Europe, Metals, [SDE]Environmental Sciences, Avaliação do Risco, Environmental Factors, Cadmium, Environmental Monitoring, soil pollutant, Environmental Engineering, metal, Fumigatus, Chemical and physical properties, chlorophyll a, chemistry, environmental factors, molds, sand, spatial distribution modelling, water, yeasts, Agentes Microbianos e Ambiente, Sediments, All institutes and research themes of the Radboud University Medical Center, Rivers, Lows-temperatures, Environmental factors, Environmental Chemistry, Spatial Distribution Modelling, Infecções Sistémicas e Zoonoses, Chlorophyll-a concentration, Beach, Water, soil property, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Probability distributions, Soils, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Soil datasets, bioclimatology
Abstract: © 2022 Elsevier B.V. All rights reserved., The present study employed data collected during the Mycosands survey to investigate the environmental factors influencing yeasts and molds distribution along European shores applying a species distribution modelling approach. Occurrence data were compared to climatic datasets (temperature, precipitation, and solar radiation), soil datasets (chemical and physical properties), and water datasets (temperature, salinity, and chlorophyll-a concentration) downloaded from web databases. Analyses were performed by MaxEnt software. Results suggested a different probability of distribution of yeasts and molds along European shores. Yeasts seem to tolerate low temperatures better during winter than molds and this reflects a higher suitability for the Northern European coasts. This difference is more evident considering suitability in waters. Both distributions of molds and yeasts are influenced by basic soil pH, probably because acidic soils are more favorable to bacterial growth. Soils with high nitrogen concentrations are not suitable for fungal growth, which, in contrast, are optimal for plant growth, favored by this environment. Finally, molds show affinity with soil rich in nickel and yeasts with soils rich in cadmium resulting in a distribution mainly at the mouths of European rivers or lagoons, where these metals accumulate in river sediments., Ana Sampaio thanks to the Foundation for Science and Technology and FEDER under Programe PT2020 for financial support to CITAB (UID/AGR/04033/2020)
Published: 2022

14. MultiLane: Lane Intention Prediction and Sensible Lane-Oriented Trajectory Forecasting on Centerline Graphs

Author: Sierra González, David, Paigwar, Anshul, Erkent, Özgür, Laugier, Christian, Robots coopératifs et adaptés à la présence humaine en environnements (CHROMA), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-CITI Centre of Innovation in Telecommunications and Integration of services (CITI), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), and Hacettepe University = Hacettepe Üniversitesi
Subjects: [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; Forecasting the motion of surrounding traffic is one of the key challenges in the quest to achieve safe autonomous driving technology. Current state-of-the-art deep forecasting architectures are capable of producing impressive results. However, in many cases, they also output completely unreasonable trajectories, making them unsuitable for deployment. In this work, we present a deep forecasting architecture that leverages the map lane centerlines available in recent datasets to predict sensible trajectories; that is, trajectories that conform to the road layout, agree with the observed dynamics of the target, and react to the presence of surrounding agents. To model such sensible behavior, the proposed architecture first predicts the lane or lanes that the target agent is likely to follow. Then, a navigational goal along each candidate lane is predicted, allowing the regression of the final trajectory in a laneand goal-oriented manner. Our experiments in the Argoverse dataset show that our architecture achieves performance onpar with lane-oriented state-of-the-art forecasting approaches and not far behind goal-oriented approaches, while consistently producing sensible trajectories.
Published: 2022

15. The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status

Author: Naciye Dilara Zeybek, Belma Giray, Alain Favier, Walid Rachidi, Murat Kızılgün, Filiz Hincal, Esin Asan, Isabelle Hininger-Favier, Pinar Erkekoglu, Department of Toxicology, Hacettepe University = Hacettepe Üniversitesi-Faculty of Pharmacy, Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Pediatric Genetics, Pediatric Hematology [Oncology Research & Training Hospital, Ankara, Turkey], Oncology Research & Training Hospital [Ankara], Lab Bioenerget Fondamentale & Appl, INSERM, U1055, Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire de biologie du stress oxydant, Department of Histology and Embryology, Hacettepe University = Hacettepe Üniversitesi-Faculty of Medicine, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Faculty of Pharmacy-Hacettepe University = Hacettepe Üniversitesi, Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Rachidi, Walid
Subjects: Male, GPX1, Antioxidant, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Apoptosis, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], 010501 environmental sciences, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, GPX4, 01 natural sciences, Rats, Sprague-Dawley, Lipid peroxidation, chemistry.chemical_compound, Selenium deficiency, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Phthalate, Catalase, 3. Good health, Liver, Biochemistry, Models, Animal, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], endocrine system, medicine.medical_specialty, chemistry.chemical_element, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pathology and Forensic Medicine, Selenium, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Diethylhexyl Phthalate, Internal medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Peroxisomes, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], medicine, Animals, Molecular Biology, 030304 developmental biology, 0105 earth and related environmental sciences, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Original Articles, Cell Biology, Glutathione, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, medicine.disease, Rats, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, Oxidative Stress, Endocrinology, chemistry, Lipid Peroxidation, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract: International audience; This study was performed to determine the hepatotoxicity of di(2‐ethylhexyl)phthalate (DEHP) in relation to selenium status. In 3‐week‐old Sprague‐Dawley rats, selenium deficiency was induced by a ≤0.05 selenium mg/kg. A selenium supplementation group was given 1 mg selenium/kg diet for 5 weeks. Di(2‐ethylhexyl)phthalate‐treated groups received 1000 mg/kg dose by gavage during the last 10 days of the experiment. Histopathology, peroxisome proliferation, catalase (CAT) immunoreactivity and activity and apoptosis were assessed. Activities of antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), glutathione peroxidase 4 (GPx4), thioredoxin reductase (TrxR1)], superoxide dismutase (SOD), and glutathione S‐transferase (GST); aminotransferase, total glutathione (tGSH), and lipid peroxidation (LP) levels were measured. Di(2‐ethylhexyl)phthalate caused cellular disorganization while necrosis and inflammatory cell infiltration were observed in Se‐deficient DEHP group (DEHP/SeD). Catalase activity and immunoreactivity were increased in all DEHP‐treated groups. Glutathione peroxidase 1 and GPx4 activities decreased significantly in DEHP and DEHP/SeD groups, while GST activities decreased in all DEHP‐exposed groups. Thioredoxin reductase activity increased in DEHP and DEHP/SeS, while total SOD activities increased in all DEHP‐treated groups. Lipid peroxidation levels increased significantly in SeD (26%), DEHP (38%) and DEHP/SeD (71%) groups. Selenium supplementation partially ameliorated DEHP‐induced hepatotoxicity; while in DEHP/SeD group, drastic changes in hepatic histopathology and oxidative stress parameters were observed.
Published: 2014

16. SARS-CoV-2 infection after vaccination in patients with inflammatory rheumatic and musculoskeletal diseases

Author: Anja Strangfeld, Ana M. Rodrigues, Loreto Carmona, Ludovic Trefond, Charalampos Papagoras, Laure Gossec, N Roux, Kimme L. Hyrich, Saskia Lawson-Tovey, Bernd Raffeiner, Elsa F Mateus, Gözde Kübra Yardımcı, Pedro Machado, Xavier Mariette, NIHR Manchester Biomedical Research Centre [Manchester] (BRC [Manchester]), Manchester Academic Health Science Centre (MAHSC), University of Manchester [Manchester], Centre for Genetics and Genomics Versus Arthritis, Centre for Epidemiology Versus Arthritis, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Deutsches Rheuma-ForschungsZentrum (DRFZ), Deutsches Rheuma-ForschungsZentrum, Instituto de Salud Musculoesqueletica (InMusc), Central Hospital of Bolzano, Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service de Médecine Interne [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Hôpital privé Robert-Schuman, Metz, France., Sociedade Portuguesa de Reumatologia [Lisboa], Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Democritus University of Thrace (DUTH), Liga Portuguesa Contra as Doenças Reumaticas (LPCDR), EULAR PARE [Zurich, Switzerland], Université Paris-Saclay, Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, University College of London [London] (UCL), NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, University College London Hospitals (UCLH), London North West University Healthcare NHS Trust (LNWH), European Alliance of Associations for Rheumatology, Service de Rhumatologie [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Molé, Christine
Subjects: Male, medicine.medical_specialty, COVID-19 Vaccines, Immunology, Population, Comorbidity, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Rheumatic Diseases, Internal medicine, Epidemiology, medicine, Humans, Immunology and Allergy, Registries, Adverse effect, education, Aged, Aged, 80 and over, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, education.field_of_study, business.industry, Abatacept, COVID-19, Middle Aged, vaccination, Vaccine efficacy, Vaccination, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Hypertension, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, epidemiology, Rituximab, business, medicine.drug
Abstract: Patients with inflammatory rheumatic and musculoskeletal diseases (iRMDs) are often treated with immunomodulatory or immunosuppressive medications; consequently, they have been excluded alongside other immunocompromised patients from late stages of SARS-CoV-2 vaccine trials. SARS-CoV-2 vaccine efficacy in this population is unclear, though initial data are reassuring overall. However, a slightly lower SARS-CoV-2 immunogenicity of vaccines has been documented in some patients with iRMD.1 2 Some common rheumatic and musculoskeletal disease (RMD) medications have been highlighted as possible influential factors on immunogenicity, particularly rituximab (RTX), mycophenolate mofetil (MMF), methotrexate (MTX), abatacept and glucocorticoids.3–7 The European Alliance of Associations for Rheumatology (EULAR) launched a COVID-19 registry in March 2020, capturing COVID-19 outcomes in the European RMD population. Questions on reinfection and vaccination were added in January 2021. A further EULAR registry (COVAX) was launched in February 2021 to collect data on COVID-19 vaccination and related adverse events among patients with RMD. Here we describe a series of patients who contracted SARS-CoV-2 infection after COVID-19 vaccination between 19 January 2021 and 27 July 2021. The series consists of 38 adults with iRMDs, 8 from the COVID-19 registry (
Published: 2021

17. The spoils of war and the long-term spoiling of health conditions of entire nations

Author: Eliano P. Navarese, Klaudyna Grzelakowska, Francesco Mangini, Jacek Kubica, Maciej Banach, Marianne Benn, Christoph J. Binder, Jan Borén, Alberico Catapano, Florian Kronenberg, Ziad Mallat, Philippe Moulin, Katariina Öörni, Kausik K. Ray, Jeanine E. Roeters van Lennep, Stefano Romeo, Lale Tokgozoglu, Arnold von Eckardstein, Alberto Zambon, Paolo Raggi, Internal Medicine, University of Zurich, Raggi, Paolo, Nicolaus Copernicus University [Toruń], University of Alberta, Ospedale Di Summa - Perrino (Brindisi) [Italy] (OSP), Medical University of Łódź (MUL), Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Copenhagen University Hospital, Medizinische Universität Wien = Medical University of Vienna, University of Gothenburg (GU), Università degli Studi di Milano = University of Milan (UNIMI), Leopold Franzens Universität Innsbruck - University of Innsbruck, University of Cambridge [UK] (CAM), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Wihuri Research Institute [Helsinki, Finland], Imperial College London, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Hacettepe University = Hacettepe Üniversitesi, Universität Zürich [Zürich] = University of Zurich (UZH), University hospital of Zurich [Zurich], Università degli Studi di Padova = University of Padua (Unipd), and CarMeN, laboratoire
Subjects: Cardiovascular Diseases/epidemiology, Noncommunicable Diseases/epidemiology, [SDV]Life Sciences [q-bio], Healthcare systems, COVID-19, 610 Medicine & health, Cardiovascular disease, 2705 Cardiology and Cardiovascular Medicine, [SDV] Life Sciences [q-bio], Remote monitoring, SDG 3 - Good Health and Well-being, Cardiovascular Diseases, covid-19, 540 Chemistry, Humans, War, Noncommunicable Diseases, Cardiology and Cardiovascular Medicine, Ukraine, Pandemics, Delivery of Health Care, 10038 Institute of Clinical Chemistry
Abstract: International audience; The healthcare system of Ukraine was already suffering from several shortfalls before February 2022, but the war of aggression started by the Russian leadership is poised to inflict a further severe blow that will have long-lasting consequences for the health of all Ukrainians. In pre-war Ukraine, noncommunicable diseases (NCDs) contributed to 91% of deaths, especially cardiovascular diseases (67%). Ukrainians have a high prevalence of risk factors for NCDs ranking among the highest levels reported by the World Health Organization (WHO) in the European (EU) Region. Cardiovascular disease is one of the key health risks for the conflict-affected Ukrainian population due to significant limitations in access to health care and interruptions in the supply of medicines and resources. The excess mortality observed during the COVID-19 pandemic, due to a combination of viral illness and chronic disease states, is bound to increase exponentially from poorly treated NCDs. In this report, we discuss the impact of the war on the public health of Ukraine and potential interventions to provide remote health assistance to the Ukrainian population.
Published: 2022

18. Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium

Author: Walid Rachidi, Isabelle Hininger-Favier, Pinar Erkekoglu, Anne-Marie Roussel, Belma Giray, Filiz Hincal, Alain Favier, Murat Kızılgün, Department of Toxicology, Faculty of Pharmacy-Hacettepe University = Hacettepe Üniversitesi, Department of Biochemistry, Hospital of Ankara-Diskapi Children's Health and Diseases, Hematology, Oncology Training, Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Hacettepe University = Hacettepe Üniversitesi-Faculty of Pharmacy, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hamant, Sarah
Subjects: medicine.medical_specialty, GPX1, endocrine system, kidney, Antioxidant, Thioredoxin-Disulfide Reductase, Health, Toxicology and Mutagenesis, medicine.medical_treatment, 010501 environmental sciences, Toxicology, medicine.disease_cause, GPX4, 01 natural sciences, Antioxidants, Superoxide dismutase, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Selenium, Plasticizers, antioxidant enzymes, Internal medicine, Diethylhexyl Phthalate, medicine, TBARS, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, oxidative stress, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Glutathione Peroxidase, biology, Phthalate, lipid peroxidation, Glutathione, Organ Size, 3. Good health, Rats, Endocrinology, Biochemistry, chemistry, selenium supplementation (SeS), biology.protein, Di(2-ethylhexyl)phthalate (DEHP), selenium deficiency (SeD), Oxidative stress
Abstract: International audience; This study was designed to examine the oxidative stress potential of di(2-ethylhexyl)phthalate (DEHP) on rat kidney and to evaluate possible protective effect of selenium (Se) status. Se deficiency (SeD) was produced in 3-week old Sprague-Dawley rats by feeding them ≤ 0.05 Se mg/kg diet for 5 weeks; Se supplementation group (SeS) was on 1 mg Se/kg diet. DEHP treated groups received 1000 mg/kg dose by gavage during the last 10 days of the feeding period. Activities of antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), glutathione peroxidase 4 (GPx4), thioredoxin reductase (TrxR)], catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST); concentrations of total glutathione (GSH), thiols and thiobarbituric acid reactive substance (TBARS) levels were measured. DEHP treatment was found to induce oxidative stress in rat kidney, as evidenced by significant decreases in GPx1 (~20%) and SOD (~30%) activities and GSH levels (~20%), along with marked decrease in thiol content (~40%) and increase in TBARS (~30%) levels. The effects of DEHP was more pronounced in SeD rats, whereas Se supplementation was protective by providing substantial elevations of GPx1 and GPx4 activities and GSH levels. These findings emphasized the critical role of Se as an effective redox regulator and the importance of Se status in protecting renal tissue from the oxidant stressor activity of DEHP.
Published: 2012

19. Palaeogeographical Reconstruction and Management Challenges of an Archaeological Site Listed by UNESCO: the Case of the Letoon Shrine in the Xanthos Plain (Turkey)

Author: Nathalie Carcaud, Catherine Kuzucuoğlu, Émilie Écochard, Eric Fouache, Jacques Des Courtils, Mehmet Ekmekci, İnan Ulusoy, Attila Çiner, Espaces, Nature et Culture (ENeC), Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de géographie physique : Environnements Quaternaires et Actuels (LGP), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Espaces et Sociétés (ESO), Le Mans Université (UM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-AGROCAMPUS OUEST-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN), Département d'hydrogéologie, Université Hacettepe, Beytepe - 06 532 Ankara, Turquie, Département d'hydrogéologie, Université Hacettepe, Hacettepe University = Hacettepe Üniversitesi-Hacettepe University = Hacettepe Üniversitesi, Department of Geological Engineering, Hacettepe University = Hacettepe Üniversitesi, Département de géologie, Département de géologie, Université Hacettepe, Beytepe, Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), LabEx Sciences archéologiques de Bordeaux (LASCARBX), Université Bordeaux Montaigne-Université de Bordeaux (UB), Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université d'Angers (UA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Le Mans Université (UM), Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne, Université de Bordeaux (UB)-Université Bordeaux Montaigne, Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Le Mans Université (UM)-Université d'Angers (UA)-AGROCAMPUS OUEST-Université de Rennes 2 (UR2)
Subjects: Delta, 010506 paleontology, geography, geography.geographical_feature_category, Marsh, Turkey, Holocene, Geoarchaeology, Hellenistic period, 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Archaeology, deltaic progradation, [SHS]Humanities and Social Sciences, archaeo-geomorphosite, General Earth and Planetary Sciences, geoarchaeology, [SHS.HIST]Humanities and Social Sciences/History, Bay, Channel (geography), Tourism, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: Palaeogeographical reconstruction and management challenges of an archaeological site listed by UNESCO: the case of the Letoon shrine in the Xanthos Plain (Turkey) During the Hellenistic period, Xanthos and Letoon were respectively a large city and an important shrine in Lycia. Questions still remain about the geography of the Eşen Çayı delta during the first millennium BC: what were the features of the landscape surrounding the Letoon shrine? Where did the riverbed lie? Our analysis is based on a reconstruction of the geomorphological dynamics at work during the Holocene. These are then compared with historical, archaeological and literary sources. Sedimentary sampling shows that a marine bay was gradually closed during the formation of a coastline spit, which led to the development of a lagoon system. Lagoons and marshes remained predominant characteristics of the plain over a long period. A branch or a former channel of the Eşen Çayı was discovered close to the Letoon shrine. In recent decades, authorities, as well as UNESCO, are now making an effort to manage palaeoenvironmental reconstructions in their promotion of the tourist potential of archaeological sites. We propose a management project for the Letoon site.
Published: 2012

20. Effects of di(2-ethylhexyl)phthalate on testicular oxidant/antioxidant status in selenium-deficient and selenium-supplemented rats

Author: Pınar, Erkekoglu, Belma, Giray, Walid, Rachidi, Isabelle, Hininger-Favier, Anne-Marie, Roussel, Alain, Favier, Filiz, Hincal, Department of Toxicology, Faculty of Pharmacy-Hacettepe University = Hacettepe Üniversitesi, Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Hamant, Sarah, Hacettepe University = Hacettepe Üniversitesi-Faculty of Pharmacy, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, endocrine system, di(ethylhexyl)phthalate, selenium deficiency, GSH/GSSG redox ratio, lipid peroxidation, selenium supplementation, Oxidants, Antioxidants, Rats, Rats, Sprague-Dawley, Random Allocation, Selenium, Plasticizers, antioxidant enzymes, Diethylhexyl Phthalate, Dietary Supplements, Testis, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, oxidative stress, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Oxidation-Reduction
Abstract: International audience; Di(ethylhexyl)phthalate (DEHP), the most widely used plasticizer, was investigated to determine whether an oxidative stress process was one of the underlying mechanisms for its testicular toxicity potential. To evaluate the effects of selenium (Se), status on the toxicity of DEHP was further objective of this study, as Se is known to play a critical role in testis and in the modulation of intracellular redox equilibrium. Se deficiency was produced in 3-weeks-old Sprague-Dawley rats feeding them ≤0.05 mg Se /kg diet for 5 weeks, and Se-supplementation group was on 1 mg Se/kg diet. DEHP-treated groups received 1000 mg/kg dose by gavage during the last 10 days of the feeding period. Activities of antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), glutathione peroxidase 4 (GPx4), thioredoxin reductase (TrxR)], catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST); concentrations of reduced glutathione (GSH), oxidized glutathione (GSSG), and thus the GSH/GSSG redox ratio; and thiobarbituric acid reactive substance (TBARS) levels were measured. DEHP was found to induce oxidative stress in rat testis, as evidenced by significant decrease in GSH/GSSG redox ratio (>10-fold) and marked increase in TBARS levels, and its effects were more pronounced in Se-deficient rats with ∼18.5-fold decrease in GSH/GSSG redox ratio and a significant decrease in GPx4 activity, whereas Se supplementation was protective by providing substantial elevation of redox ratio and reducing the lipid peroxidation. These findings emphasized the critical role of Se as an effective redox regulator and the importance of Se status in protecting testicular tissue from the oxidant stressor activity of DEHP. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2011.
Published: 2011

21. Reproductive toxicity of di(2-ethylhexyl) phthalate in selenium-supplemented and selenium-deficient rats

Author: Filiz Hincal, Josiane Arnaud, N. Dilara Zeybek, Esin Asan, Pinar Erkekoglu, Belma Giray, Department of Toxicology, Hacettepe University = Hacettepe Üniversitesi-Faculty of Pharmacy, Department of Histology and Embryology, Hacettepe University = Hacettepe Üniversitesi-Faculty of Medicine, Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hamant, Sarah
Subjects: LH, MESH: Selenium, Male, MESH: Organ Size, Health, Toxicology and Mutagenesis, Developmental toxicity, MESH: Dietary Supplements, MESH: Rats, Sprague-Dawley, 010501 environmental sciences, Endocrine Disruptors, MESH: Reproduction, Toxicology, 01 natural sciences, Rats, Sprague-Dawley, chemistry.chemical_compound, Phthalates, Selenium deficiency, FSH, MESH: Follicle Stimulating Hormone, Testis, MESH: Animals, Sperm motility, Testosterone, Epididymis, 0303 health sciences, MESH: Sperm Count, Sperm Count, selenium deficiency, MESH: Testis, Reproduction, MESH: Spermatozoa, Phthalate, selenium supplementation, MESH: Sperm Motility, General Medicine, Organ Size, Spermatozoa, MESH: Endocrine Disruptors, 3. Good health, Liver, Data Interpretation, Statistical, Toxicity, Sperm Motility, di(ethylhexyl) phthalate (DEHP), Reproductive toxicity, endocrine system, medicine.medical_specialty, MESH: Rats, MESH: Epididymis, Biology, sperm, 03 medical and health sciences, Selenium, MESH: Luteinizing Hormone, Internal medicine, Diethylhexyl Phthalate, MESH: Diethylhexyl Phthalate, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030304 developmental biology, 0105 earth and related environmental sciences, Pharmacology, Chemical Health and Safety, Public Health, Environmental and Occupational Health, Luteinizing Hormone, medicine.disease, testicular histopathology, MESH: Male, Rats, Endocrinology, chemistry, testosterone, Dietary Supplements, Follicle Stimulating Hormone, MESH: Data Interpretation, Statistical, Spermatogenesis, MESH: Liver
Abstract: International audience; Phthalates are abundantly produced plasticizers, and di(ethylhexyl) phthalate (DEHP) is the most widely used derivative in various consumer products and medical devices. Animal studies show that DEHP and various other phthalates cause reproductive and developmental toxicity. Although the evidences are limited, it seems reasonable that DEHP may have a potential for similar adverse effects in humans. Such concerns are increasing, particularly for the developing reproductive system of male infants and children. By taking into account the essentiality of selenium (Se) in testicular structure and functions and the high prevalence of inadequate Se intake in various part of the world, this study was designed to investigate the testicular toxicity of DEHP in Se-deficient male rats and to examine the possible preventive effects of Se supplementation on phthalate toxicity. Se deficiency was generated by feeding 3-week-old Sprague-Dawley rats with a ≤0.05 Se mg/kg diet for 5 weeks. Supplementation groups were on a 1 mg Se/kg diet, and DEHP-treated groups received a 1,000 mg/kg dose by gavage during the last 10 days of the feeding period. Testicular histopathology, sperm count and motility, and sperm morphology were examined, and plasma levels of sex hormones were measured. Toxicity and antiandrogenic effects of DEHP were evidenced by disturbed testicular histology and spermatogenesis, diminished testosterone, leutinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and sperm motility. The effects of DEHP were much more pronounced in Se-deficient rats, whereas Se supplementation was found to be protective, reflecting its regulating role in cellular redox equilibrium.
Published: 2011

22. Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities

Author: Rüveyde Keleş Atıcı, Şengül Dilem Doğan, Miyase Gözde Gündüz, Vagolu Siva Krishna, Melina Chebaiki, Håvard Homberset, Christian Lherbet, Lionel Mourey, Tone Tønjum, Erciyes University, Hacettepe University = Hacettepe Üniversitesi, University of Oslo (UiO), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Molecular Docking Simulation, Bacterial Proteins, Drug Discovery, Antitubercular Agents, Urea, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Microbial Sensitivity Tests
Abstract: © 2022 Wiley Periodicals LLC.The recent emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life-threatening acute and chronic cases of tuberculosis. To overcome this setback, researchers have increased the intensity of their work to identify new small-molecule compounds that are expected to remain efficacious antimicrobials against Mtb. Here, we describe our effort to apply the principles of molecular hybridization to synthesize 16 compounds carrying thiophene and thiazole rings beside the core urea functionality (TTU1–TTU16). Following extensive structural characterization, the obtained compounds were initially evaluated for their antimycobacterial activity against Mtb H37Rv. Subsequently, three derivatives standing out with their anti-Mtb activity profiles and low cytotoxicity (TTU5, TTU6, and TTU12) were tested on isoniazid-resistant clinical isolates carrying katG and inhA mutations. Additionally, due to their pharmacophore similarities to the well-known InhA inhibitors, the molecules were screened for their enoyl acyl carrier protein reductase (InhA) inhibitory potentials. Molecular docking studies were performed to support the experimental enzyme inhibition data. Finally, drug-likeness of the selected compounds was established by theoretical calculations of physicochemical descriptors.
Published: 2022

23. The current state of laboratory mycology and access to antifungal treatment in Europe: a European Confederation of Medical Mycology survey

Author: Jon Salmanton-García, Martin Hoenigl, Jean-Pierre Gangneux, Esther Segal, Ana Alastruey-Izquierdo, Sevtap Arikan Akdagli, Katrien Lagrou, Volkan Özenci, Antonio Vena, Oliver A Cornely, Universität zu Köln = University of Cologne, Medical University of Graz, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Kfar Saba and Sackler School of Medicine, Instituto de Salud Carlos III [Madrid] (ISC), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Karolinska Institute, and Università degli studi di Genova = University of Genoa (UniGe)
Subjects: Microbiology (medical), Europe, Echinocandins, Infectious Diseases, Antifungal Agents, Virology, [SDV]Life Sciences [q-bio], Humans, Mycology, Microbiology, Invasive Fungal Infections
Abstract: Access to the appropriate tools is crucial for early diagnosis and clinical management of invasive fungal infections. This Review aims to describe the invasive fungal infection diagnostic capacity of Europe to better understand the status and the most pressing aspects that need improvement. To our knowledge, this is the first time that the mycological diagnostic capability and access to antifungal treatments of institutions has been evaluated at a pan-European level. Between Nov 1, 2021, and Jan 31, 2022, 388 institutions in Europe self-assessed their invasive fungal infection management capability. Of the 388 participating institutions from 45 countries, 383 (99%) had access to cultures, 375 (97%) to microscopy, 363 (94%) to antigen-detection assays, 329 (85%) to molecular tests (mostly PCR), and 324 (84%) to antibody tests for diagnosis and management. With the exception of microscopy, there were considerable differences in access to techniques among countries according to their gross domestic product. At least one triazole was available in 363 (94%) of the institutions, one echinocandin in 346 (89%), and liposomal amphotericin B in 301 (78%), with country gross domestic product-based differences. Differences were also observed in the access to therapeutic drug monitoring. Although Europe is well prepared to manage invasive fungal infections, some institutions do not have access to certain diagnostic tools and antifungal drugs, despite most being considered essential by WHO. These limitations need to be overcome to ensure that all patients receive the best diagnostic and therapeutic management. ispartof: Lancet Microbe vol:4 issue:1 pages:e47-e56 ispartof: location:England status: published
Published: 2022

24. Reconstitution paléogéographique des dynamiques paysagères durant l'Holocène autour de Xanthos et Létôon dans l'ancienne Lycie (Turquie) : premiers résultats

Author: İnan Ulusoy, Émilie Écochard, Catherine Kuzucuoğlu, Attila Çiner, Mehmet Ekmekci, Nathalie Carcaud, Jacques Des Courtils, Eric Fouache, Laboratoire de géographie physique : Environnements Quaternaires et Actuels (LGP), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Unité Paysage et Ecologie (PAYSAGE), AGROCAMPUS OUEST-Ecole supérieure d'Agricultures d'Angers (ESA), Département d'hydrogéologie, Université Hacettepe, Beytepe - 06 532 Ankara, Turquie, Département d'hydrogéologie, Université Hacettepe, Hacettepe University = Hacettepe Üniversitesi-Hacettepe University = Hacettepe Üniversitesi, Département de géologie, Département de géologie, Université de Lund, Université de Lund-Université de Lund, Département de géologie, Université Hacettepe, Beytepe, Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), LabEx Sciences archéologiques de Bordeaux (LASCARBX), Université de Bordeaux (UB)-Université Bordeaux Montaigne, ANR-06-BLAN-0358,EUPLOIA,EUPLOIA. Dynamiques de la Méditerranée antique : le cas de l'Asie Mineure du sud-ouest(2006), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Ecole supérieure d'Agricultures d'Angers (ESA), Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne, and Université Bordeaux Montaigne-Université de Bordeaux (UB)
Subjects: 010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, General Earth and Planetary Sciences, 010502 geochemistry & geophysics, 01 natural sciences, 0105 earth and related environmental sciences, General Environmental Science
Abstract: Selon Strabon, Xanthos et Létôon étaient une cité et un sanctuaire majeurs de Lycie à la période hellénistique (ive-iie siècles av. J.-C.). L’archéologue qui étudie ces deux sites ne peut faire l’hypothèse que le paysage dans lequel ils se situent est resté immobile depuis l’arrivée des premiers habitants au viie siècle av. J.-C. Comprendre les sociétés qui ont occupé cet espace, ainsi que leurs relations avec l’environnement, implique de reconstituer les paysages qu’elles ont habités et aménagés, en s’appuyant sur la compréhension des conditions environnementales et des dynamiques géomorphologiques qui s’y sont exercées. Dans cet article, les premiers résultats issus de l’analyse de séquences carottées et de profils géophysiques sont interprétés et confrontés aux sources historiques, archéologiques et littéraires, et une première reconstitution de l’évolution des paysages est proposée. Les enregistrements sédimentaires indiquent qu’une baie marine a été progressivement fermée par le développement d’une flèche littorale à l’arrière de laquelle s’établissait un système lagunaire. C’est dans ce contexte paysager que se sont développés les deux sites. Face au Létôon un ancien chenal a été identifié, qui permettait peut-être une relation directe, par le fleuve, du sanctuaire avec la mer en aval, et avec la cité de Xanthos en amont. L’étude de la morphologie de la vallée dans son ensemble révèle une forte mobilité des paysages, qui a contraint les hommes à choisir des sites protégés dans des lieux stratégiques pour y installer leurs cités, leurs sanctuaires et leurs voies de communication. La mobilité des paysages a aussi été exploitée de manière symbolique : installé dans un environnement hostile de marécages en plaine alluviale, le sanctuaire de Létôon se pose comme un défi aux lois de la nature. According to Strabo, Xanthos and Letoon were very important cities and major shrines in the Lycia region during the Hellenistic period (4th-2th centuries BC). An archaeological study of these sites cannot assume that their environment has not changed since the arrival of the ﬁrst settlers in the seventh century BC. Understanding societies who have occupied this region and their relationship with their environment involves the reconstruction of the landscapes they inhabited, including past geomorphological dynamics. In this paper, the preliminary reconstruction of the changing landscape is based on results of analyses of cores and of geophysical proﬁles. These data are compared with historical, archaeological and literary sources. The sedimentary records indicate that a marine bay was gradually filled-in by invading coastal sand deposits, prompting the appearance of a lagoon system, in relation to which both sites most probably developed. A palaeo-channel of the river Eşen Çayı has been identiﬁed close to the Letoon site. It probably provided a direct connection by boat between the holy place, the sea, and the city of Xanthos upstream. The study of the morphology of the valley reveals the high mobility of landscapes through time, which forced men to carefully choose the location of their settlements and roads. This mobility was also exploited with a symbolic purpose: the Letoon shrine was installed in a hostile environment of wetlands, as a challenge to the laws of nature.
Published: 2009

25. Minimum Information for Reporting on the Comet Assay (MIRCA)

Author: Andrew Collins, Mirta Milić, Cristian Del Bo, Elisa Boutet-Robinet, Lisa Giovannelli, Amaya Azqueta, Stefano Bonassi, Gunnar Brunborg, Sabine A. S. Langie, Monika Sramkova, Matjaz Novak, Solange Costa, Alena Gábelová, Goran Gajski, Helga Stopper, Roger W. L. Godschalk, Maria Dusinska, Bojana Zegura, Elke Richling, Marcus S. Cooke, Sona Vodenkova, Kristine B. Gutzkow, Vanessa Moraes de Andrade, Cristiana Pereira, Nurşen Başaran, Blanca Laffon, João Paulo Teixeira, Peter Møller, Gudrun Koppen, Pavel Vodicka, Vanessa Valdiglesias, Azqueta, Amaya/0000-0003-4857-9931, Pereira, Cristiana/0000-0002-2146-1223, bonassi, stefano/0000-0003-3833-6717, Boutet-Robinet, Elisa/0000-0002-5223-4568, Paulo Teixeira, Joao/0000-0001-8693-5250, University of Copenhagen = Københavns Universitet (KU), Universidad de Navarra [Pamplona] (UNAV), IdiSNA, Navarra Institute for Health Research, Contaminants & Stress Cellulaire (ToxAlim-COMICS), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Flemish Institute for Technological Research (VITO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Institute for Medical Research and Occupational Health, Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Universidade do Porto, Norwegian Institute for Air Research (NILU), School of Nutrition and Translational Research in Metabolism [Maastricht] (NUTRIM), Maastricht University [Maastricht], Norwegian Institute of Public Health [Oslo] (NIPH), NEUROFARBA Department [Firenze, Italy], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), University of South Florida [Tampa] (USF), Food Chemistry and Toxicology [Kaiserslautern, Germany] (Department of Chemistry), University of Kaiserslautern-University of Kaiserslautern [Germany], Universidade da Coruña, Instituto de Investigación Biomédica de A Coruña [La Corogne, Espagne] (INIBIC), A Coruña University Hospital [La Corogne, Espagne], Hacettepe University = Hacettepe Üniversitesi, Università degli Studi di Milano [Milano] (UNIMI), National Institute of Biology [Ljubljana] (NIB), University of Würzburg, Czech Academy of Sciences [Prague] (CAS), Charles University [Prague] (CU), University of Southern Santa Catarina [Florianopolis] (UNISUL), Slovak Academy of Sciences (SAS), University of Oslo (UiO), Hasselt University (UHasselt), Instituto de Saúde Pública da Universidade do Porto, Farmacologie en Toxicologie, and RS: NUTRIM - R3 - Respiratory & Age-related Health
Subjects: Consensus, Computer science, MIGRATION, [SDV]Life Sciences [q-bio], Recommendations, OXIDATION, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, WHALES, 0302 clinical medicine, INTER-LABORATORY VARIATION, Humans, Experimental work, 030304 developmental biology, Protocol (science), REPAIR, 0303 health sciences, Consensus Statement, food and beverages, BASE, 3. Good health, TIME, Comet assay, Risk analysis (engineering), Risk factors, DNA-DAMAGE, ANIMAL-MODELS, Research Design, 030220 oncology & carcinogenesis, comet assay, variability, information, CELLS, Minimum Information for Reporting Comet Assay (MIRCA), Comet Assay, Guideline Adherence, Laboratories, Biomarkers, DNA Damage
Abstract: The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. These differences may be attributed to protocol differences, although it is difficult to identify the relevant conditions because detailed comet assay procedures are not always published. Here, we present a Consensus Statement for the Minimum Information for Reporting Comet Assay (MIRCA) providing recommendations for describing comet assay conditions and results. These recommendations differentiate between ‘desirable’ and ‘essential’ information: ‘essential’ information refers to the precise details that are necessary to assess the quality of the experimental work, whereas ‘desirable’ information relates to technical issues that might be encountered when repeating the experiments. Adherence to MIRCA recommendations should ensure that comet assay results can be easily interpreted and independently verified by other researchers., Here, members of the hCOMET COST Action program provide a consensus statement on the Minimum Information for Reporting Comet Assays (MIRCA).
Published: 2020

26. Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment

Author: Michelangela Barbieri, Aleksandra Klimkowicz-Mrowiec, Goce Spasovski, Liliana Garneata, Sophie Liabeuf, Carmen Antonia Mocanu, Carmine Zoccali, Sol Carriazo, Olivier Godefroy, Konstantinos Giannakou, Mustafa Arici, Andrzej Wiecek, Evgueniy Vazelov, Tomasz Grodzicki, Marion Pépin, Ziad A. Massy, Giuseppe Paolisso, Pilar Delgado, Davide Viggiano, Maie Bachman, Justina Kurganaite, Ana Carina Ferreira, Inga Arune Bumblyte, Hôpital Ambroise Paré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hospital Curry Cabral [Lisbon, Portugal], Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Hacettepe University = Hacettepe Üniversitesi, Tallinn University of Technology (TTÜ), University of the Study of Campania Luigi Vanvitelli, Lithuanian University of health Sciences [Kaunas], Fundacion Jimenez Diaz [Madrid] (FJD), Universitat Autònoma de Barcelona (UAB), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), European University of Cyprus, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Medical University of Sofia [Bulgarie], Medical University of Silesia (SUM), CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target): Giovambattista Capasso, Alexandre Andrade, Maie Bachmann, Inga Bumblyte, Adrian Constantin Covic, Pilar Delgado, Nicole Endlich, Andreas Engvig, Denis Fouque, Casper Franssen, Sebastian Frische, Liliana Garneata, Loreto Gesualdo, Konstantinos Giannakou, Dimitrios Goumenos, Ayşe Tuğba Kartal, Laila-Yasmin Mani, Hans-Peter Marti, Christopher Mayer, Rikke Nielsen, Vesna Pešić, Merita Rroji, Giorgos Sakkas, Goce Spasovski, Kate I Stevens, Evgueniy Vazelov, Davide Viggiano, Lefteris Zacharia, Ana Carina Ferreira, Jolanta Malyszko, Ewout Hoorn, Andreja Figurek, Robert Unwin, Carsten Wagner, Christoph Wanner, Annette Bruchfeld, Marion Pepin, Andrzej Wiecek, Dorothea Nitsch, Ivo Fridolin, Gaye Hafez, Maria José Soler Romeo, Michelangela Barbieri, Bojan Batinić, Laura Carrasco, Sol Carriazo, Ron Gansevoort, Gianvito Martino, Francesco Mattace Raso, Ionut Nistor, Alberto Ortiz, Giuseppe Paolisso, Daiva Rastenytė, Gabriel Stefan, Gioacchino Tedeschi, Ziad Massy, Boris Bikbov, Karl Hans Endlich, Olivier Godefroy, Jean-Marc Chillon, Anastassia Kossioni, Justina Kurganaite, Norberto Perico, Giuseppe Remuzzi, Tomasz Grodzicki, Francesco Trepiccione, Carmine Zoccali, Mustafa Arici, Peter Blankestijn, Kai-Uwe Eckardt, Danilo Fliser, Eugenio Gutiérrez Jiménez, Maximilian Konig, Ivan Rychlik, Michela Deleidi, George Reusz, DESSAIVRE, Louise, Internal Medicine, Pepin, M., Ferreira, A. C., Arici, M., Bachman, M., Barbieri, M., Bumblyte, I. A., Carriazo, S., Delgado, P., Garneata, L., Giannakou, K., Godefroy, O., Grodzicki, T., Klimkowicz-Mrowiec, A., Kurganaite, J., Liabeuf, S., Mocanu, C. A., Paolisso, G., Spasovski, G., Vazelov, E. S., Viggiano, D., Zoccali, C., Massy, Z. A., and Wiecek, A.
Subjects: medicine.medical_specialty, Review, urologic and male genital diseases, comprehensive battery, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Pharmacotherapy, medicine, Cognitive decline, Intensive care medicine, Cognitive impairment, AcademicSubjects/MED00340, Kidney transplantation, cognitive impairment, Transplantation, business.industry, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, cognitive screening test, clinical assessment, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Cognitive test, Nephrology, business, Neurocognitive, chronic kidney disease, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Kidney disease
Abstract: Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide appropriate patient and caregiver support. Numerous factors are associated with the development and progression of CI in CKD patients and various conditions can influence the results of cognitive assessment in these patients. Here we review clinical warning signs that should lead to cognitive screening; conditions frequent in CKD at risk to interfere with cognitive testing or performance, including specificities of cognitive assessment in dialysis patients or after kidney transplantation; and available tests for screening and observed cognitive patterns in CKD patients., Graphical Abstract Graphical abstract
Published: 2022

27. Analyzing central-line associated bloodstream infection prevention bundles in 22 countries: The results of ID-IRI survey

Author: Ilker Devrim, Hakan Erdem, Amani El-Kholy, Abdullah Almohaizeie, Mateja Logar, Bilal Ahmad Rahimi, Fatma Amer, Sevil Alkan-Ceviker, Meliha Cagla Sonmezer, Maya Belitova, Jamal Wadi Al-Ramahi, Natalia Pshenichnaya, Maha Ali Gad, Lurdes Santos, Reham Khedr, Abdullahi Nur Hassan, Elif Boncuoglu, Andrea Cortegiani, Andrea Marino, Anna Liskova, Atousa Hakamifard, Corneliu Petru Popescu, Mumtaz Ali Khan, Ralitsa Marinova, Nikolaj Petrov, Emmanuel Nsutebu, Ghaydaa Shehata, Hamed Azhdari Tehrani, Handan Alay, Ivana Mareković, Joanna Zajkowska, Aidos Konkayev, Manar Ezzelarab Ramadan, Michele Pagani, Hasan Agin, Pierre Tattevin, Rehab El-Sokkary, Rezaul Karim Ripon, Ricardo Fernandez, Rosa Fontana Del Vecchio, Simona Daniela Popescu, Souha Kanj, Dr Behcet Uz Children Res & Training Hosp, Cairo University, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Zagazig University, Çanakkale Onsekiz Mart University (COMU), Hacettepe University = Hacettepe Üniversitesi, The University of Jordan (JU), Central Research Institute of Epidemiology [Moscow], Hospital de São João [Porto], Università degli studi di Palermo - University of Palermo, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Medical Military Academy, Medical Military Academy Sofia, Assiut University, Ataturk University, Galala University [Suez, Egypt], Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), American University of Beirut Faculty of Medicine and Medical Center (AUB), Devrim, Ilker, Erdem, Hakan, El-Kholy, Amani, Almohaizeie, Abdullah, Logar, Mateja, Rahimi, Bilal Ahmad, Amer, Fatma, Alkan-Ceviker, Sevil, Sonmezer, Meliha Cagla, Belitova, Maya, Al-Ramahi, Jamal Wadi, Pshenichnaya, Natalia, Gad, Maha Ali, Santos, Lurde, Khedr, Reham, Hassan, Abdullahi Nur, Boncuoglu, Elif, Cortegiani, Andrea, Marino, Andrea, Liskova, Anna, Hakamifard, Atousa, Popescu, Corneliu Petru, Khan, Mumtaz Ali, Marinova, Ralitsa, Petrov, Nikolaj, Nsutebu, Emmanuel, Shehata, Ghaydaa, Tehrani, Hamed Azhdari, Alay, Handan, Mareković, Ivana, Zajkowska, Joanna, Konkayev, Aido, Ramdan, Manar Ezz Elarab, Pagani, Michele, Agin, Hasan, Tattevin, Pierre, El-Sokkary, Rehab, Ripon, Rezaul Karim, Fernandez, Ricardo, Vecchio, Rosa Fontana Del, Popescu, Simona Daniela, and Kanj, Souha
Subjects: Catheter, Infection Control, Catheterization, Central Venous, Cross Infection, Epidemiology, Health Policy, Public Health, Environmental and Occupational Health, Bundle, CLABSI, Central line, Infection, Sepsis, Intensive Care Units, Infectious Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Catheter-Related Infections, Surveys and Questionnaires, Humans, Central Venous Catheters, Patient Care Bundles
Abstract: International audience; BACKGROUND: Because central line-associated bloodstream infections (CLABSIs) are a significant complication of central venous access, it is critical to prevent CLABSIs through the use of central line bundles. The purpose of this study was to take a snapshot of central venous access bundles in various countries. METHODS: The participants in intensive care units (ICUs) completed a questionnaire that included information about the health center, infection control procedures, and central line maintenance. The countries were divided into 2 groups: those with a low or low-middle income and those with an upper-middle or high income. RESULTS: Forty-three participants from 22 countries (46 hospitals, 85 ICUs) responded to the survey. Eight (17.4%) hospitals had no surveillance system for CLABSI. Approximately 7.1 % (n = 6) ICUs had no CLABSI bundle. Twenty ICUs (23.5%) had no dedicated checklist. The percentage of using ultrasonography during catheter insertion, transparent semi-permeable dressings, needleless connectors and single-use sterile pre-filled ready to use 0.9% NaCl were significantly higher in countries with higher and middle-higher income (P < .05). CONCLUSIONS: Our study demonstrated that there are significant differences in the central line bundles between low/low-middle income countries and upper-middle/high-income countries. Additional measures should be taken to address inequity in the management of vascular access in resource-limited countries.
Published: 2022

28. Honey bees and climate explain viral prevalence in wild bee communities on a continental scale

Author: Niels Piot, Oliver Schweiger, Ivan Meeus, Orlando Yañez, Lars Straub, Laura Villamar-Bouza, Pilar De la Rúa, Laura Jara, Carlos Ruiz, Martin Malmstrøm, Sandra Mustafa, Anders Nielsen, Marika Mänd, Reet Karise, Ivana Tlak-Gajger, Erkay Özgör, Nevin Keskin, Virginie Diévart, Anne Dalmon, Anna Gajda, Peter Neumann, Guy Smagghe, Peter Graystock, Rita Radzevičiūtė, Robert J. Paxton, Joachim R. de Miranda, Universiteit Gent = Ghent University (UGENT), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), German Centre for Integrative Biodiversity Research (iDiv), Institute of Bee Health, University of Bern, European Food Safety Authority (EFSA), Universidad de Murcia, Universidad de La Laguna [Tenerife - SP] (ULL), Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Martin-Luther-University Halle-Wittenberg, University of Pretoria [South Africa], Norsk institutt for bioøkonomi=Norwegian Institute of Bioeconomy Research (NIBIO), Estonian University of Life Sciences (EMU), University of Zagreb, Cyprus International University, Hacettepe University = Hacettepe Üniversitesi, Abeilles et Environnement (AE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Warsaw University of Life Sciences (SGGW), Imperial College London, Leipzig University, Swedish University of Agricultural Sciences (SLU), and European Project: COST
Subjects: Agriculture and Food Sciences, Viral epidemiology, PARASITES, Climate Change, Rain, Science, viruses, Virus-host interactions, ECOLOGY, complex mixtures, Article, BUMBLEBEES, BOMBUS-TERRESTRIS, Stress, Physiological, Animals, RNA Viruses, INFECTIOUS-DISEASES, TEMPERATURE, PATHOGENS, Multidisciplinary, 630 Agriculture, [SDV.BA]Life Sciences [q-bio]/Animal biology, fungi, Temperature, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Bees, APIS-MELLIFERA L, viral prevalence, wild bees, honeybees, climate, Virus Diseases, Host-Pathogen Interactions, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Dicistroviridae, behavior and behavior mechanisms, Medicine, 590 Animals (Zoology), POPULATIONS, ACUTE PARALYSIS VIRUS, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: Viruses are omnipresent, yet the knowledge on drivers of viral prevalence in wild host populations is often limited. Biotic factors, such as sympatric managed host species, as well as abiotic factors, such as climatic variables, are likely to impact viral prevalence. Managed and wild bees, which harbor several multi-host viruses with a mostly fecal–oral between-species transmission route, provide an excellent system with which to test for the impact of biotic and abiotic factors on viral prevalence in wild host populations. Here we show on a continental scale that the prevalence of three broad host viruses: the AKI-complex (Acute bee paralysis virus, Kashmir bee virus and Israeli acute paralysis virus), Deformed wing virus, and Slow bee paralysis virus in wild bee populations (bumble bees and solitary bees) is positively related to viral prevalence of sympatric honey bees as well as being impacted by climatic variables. The former highlights the need for good beekeeping practices, including Varroa destructor management to reduce honey bee viral infection and hive placement. Furthermore, we found that viral prevalence in wild bees is at its lowest at the extreme ends of both temperature and precipitation ranges. Under predicted climate change, the frequency of extremes in precipitation and temperature will continue to increase and may hence impact viral prevalence in wild bee communities.
Published: 2022

29. Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity

Author: Ebru Koçak Aslan, Muhammed İhsan Han, Vagolu Siva Krishna, Rasoul Tamhaev, Cagatay Dengiz, Şengül Dilem Doğan, Christian Lherbet, Lionel Mourey, Tone Tønjum, Miyase Gözde Gündüz, Hacettepe University = Hacettepe Üniversitesi, Erciyes University, University of Oslo (UiO), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and Middle East Technical University [Ankara] (METU)
Subjects: InhA, molecular modeling, Drug Discovery, Pharmaceutical Science, Molecular Medicine, antimycobacterial, Mycobacterium tuberculosis, drug-resistant clinical isolates, [CHIM.THER]Chemical Sciences/Medicinal Chemistry
Abstract: Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emerging INH-resistant strains of Mycobacterium tuberculosis (Mtb). In the present study, we aimed to chemically tailor INH to overcome this resistance. We obtained thirteen novel compounds by linking INH to in-house synthesized sulfonate esters via a hydrazone bridge (SIH1–SIH13). Following structural characterization by FTIR, 1H NMR, 13C NMR, and HRMS, all compounds were screened for their antitubercular activity against Mtb H37Rv strain and INH-resistant clinical isolates carrying katG and inhA mutations. Additionally, the cytotoxic effects of SIH1–SIH13 were assessed on three different healthy host cell lines; HEK293, IMR-90, and BEAS-2B. Based on the obtained data, the synthesized compounds appeared as attractive antimycobacterial drug candidates with low cytotoxicity. Moreover, the stability of the hydrazone moiety in the chemical structure of the final compounds was confirmed by using UV/Vis spectroscopy in both aqueous medium and DMSO. Subsequently, the compounds were tested for their inhibitory activities against enoyl acyl carrier protein reductase (InhA), the primary target enzyme of INH. Although most of the synthesized compounds are hosted by the InhA binding pocket, SIH1–SIH13 do not primarily show their antitubercular activities by direct InhA inhibition. Finally, in silico determination of important physicochemical parameters of the molecules showed that SIH1–SIH13 adhered to Lipinski’s rule of five. Overall, our study revealed a new strategy for modifying INH to cope with the emerging drug-resistant strains of Mtb.
Published: 2022

30. Information Literacy in a Post-Truth Era

Author: Kurbanoğlu, Serap, Špiranec, Sonja, Ünal, Yurdagül, Boustany, Joumana, Kos, Denis, Hacettepe University = Hacettepe Üniversitesi, University of Zagreb, Dispositifs d'Information et de Communication à l'Ère du Numérique - Paris Île-de-France (DICEN-IDF), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Gustave Eiffel
Subjects: [SHS.INFO]Humanities and Social Sciences/Library and information sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2022

31. Safety of Vaccination against SARS-CoV-2 in People with Rheumatic and Musculoskeletal Diseases: Results from the EULAR Coronavirus Vaccine (COVAX) Physician-Reported Registry

Author: Pedro M Machado, Saskia Lawson-Tovey, Anja Strangfeld, Elsa F Mateus, Kimme L Hyrich, Laure Gossec, Loreto Carmona, Ana Rodrigues, Bernd Raffeiner, Catia Duarte, Eric Hachulla, Eric Veillard, Eva Strakova, Gerd R Burmester, Gözde Kübra Yardımcı, Jose A Gomez-Puerta, Julija Zepa, Lianne Kearsley-Fleet, Ludovic Trefond, Maria Cunha, Marta Mosca, Martina Cornalba, Martin Soubrier, Nicolas Roux, Olivier Brocq, Patrick Durez, Richard Conway, Tiphaine Goulenok, Johannes WJ Bijlsma, Iain B McInnes, Xavier Mariette, University College London Hospitals (UCLH), Manchester Academic Health Science Centre (MAHSC), University of Manchester [Manchester], Centre for Genetics and Genomics Versus Arthritis, Deutsches Rheuma-ForschungsZentrum (DRFZ), Deutsches Rheuma-ForschungsZentrum, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Instituto de Salud Musculoesqueletica (InMusc), Central Hospital of Bolzano, Centro Hospitalar e Universitário [Coimbra], CHU Lille, Department of Rheumatology and Clinical Immunology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service de Médecine Interne [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, University of Pisa - Università di Pisa, CHU Clermont-Ferrand, Hôpital Princesse Grace [Monaco], Cliniques Universitaires Saint-Luc [Bruxelles], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University Medical Center [Utrecht], Hôpital Bicêtre, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, and UCL - (SLuc) Service de rhumatologie
Subjects: Male, COVID-19 Vaccines, antirheumatic agents, Epidemiology, [SDV]Life Sciences [q-bio], Immunology, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Muscular Diseases, Rheumatic Diseases, Immunology and Allergy, Humans, autoimmune diseases, Musculoskeletal Diseases, Registries, skin and connective tissue diseases, Aged, SARS-CoV-2, Vaccination, COVID-19, Middle Aged, Female, epidemiology, Rheumatologists, Immunosuppressive Agents
Abstract: ObjectivesTo describe the safety of vaccines against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD).MethodsPhysician-reported registry of I-RMD and non-inflammatory RMD (NI-RMDs) patients vaccinated against SARS-CoV-2. From 5 February 2021 to 27 July 2021, we collected data on demographics, vaccination, RMD diagnosis, disease activity, immunomodulatory/immunosuppressive treatments, flares, adverse events (AEs) and SARS-CoV-2 breakthrough infections. Data were analysed descriptively.ResultsThe study included 5121 participants from 30 countries, 90% with I-RMDs (n=4604, 68% female, mean age 60.5 years) and 10% with NI-RMDs (n=517, 77% female, mean age 71.4). Inflammatory joint diseases (58%), connective tissue diseases (18%) and vasculitis (12%) were the most frequent diagnostic groups; 54% received conventional synthetic disease-modifying antirheumatic drugs (DMARDs), 42% biological DMARDs and 35% immunosuppressants. Most patients received the Pfizer/BioNTech vaccine (70%), 17% AstraZeneca/Oxford and 8% Moderna. In fully vaccinated cases, breakthrough infections were reported in 0.7% of I-RMD patients and 1.1% of NI-RMD patients. I-RMD flares were reported in 4.4% of cases (0.6% severe), 1.5% resulting in medication changes. AEs were reported in 37% of cases (37% I-RMD, 40% NI-RMD), serious AEs in 0.5% (0.4% I-RMD, 1.9% NI-RMD).ConclusionThe safety profiles of SARS-CoV-2 vaccines in patients with I-RMD was reassuring and comparable with patients with NI-RMDs. The majority of patients tolerated their vaccination well with rare reports of I-RMD flare and very rare reports of serious AEs. These findings should provide reassurance to rheumatologists and vaccine recipients and promote confidence in SARS-CoV-2 vaccine safety in I-RMD patients.
Published: 2022

32. Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjogren's syndrome

Author: Marie Wahren-Herlenius, Xavier Mariette, Jacques-Eric Gottenberg, Manuel Ramos-Casals, Chiara Baldini, Aike A. Kruize, Bei Xu, Virginia Fernandes Moça Trevisani, Gabriela Hernández-Molina, Jorge Sanchez-Guerrero, Pilar Brito-Zerón, Sung-Hwan Park, Sandra Gofinet Pasoto, Valeria Valim, Roberto Giacomelli, Roberta Priori, Kathy L. Sivils, Maureen Rischmueller, Wan-Fai Ng, Margit Zeher, Damien Sène, Berkan Armagan, Yasunori Suzuki, Valérie Devauchelle-Pensec, Marika Kvarnström, Soledad Retamozo, Guadalupe Fraile, Gunnel Nordmark, Sonja Praprotnik, Luca Quartuccio, Jacques Morel, Piotr Wiland, David A. Isenberg, Astrid Rasmussen, Seung-Ki Kwok, Stefano Bombardieri, Salvatore De Vita, Hendrika Bootsma, Benedikt Hofauer, Tamer A. Gheita, Thomas Mandl, Fabiola Atzeni, Xiaomei Li, Michele Bombardieri, Daniel Hammenfors, Antonina Minniti, Nihan Acar-Denizli, Roberto Gerli, Roser Solans, Levent Kilic, Eefje van der Heijden, Pulukool Sandhya, Hideki Nakamura, Raphaèle Seror, Debashish Danda, Ildikó Horváth, C. Vollenweider, Hospital Clinic (IDIBAPS), Mimar Sinan Üniversitesi, Institute of Cellular Medicine [Newcastle], Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation (OMRF), CHU Le Kremlin-Bicêtre (Rheumatology Department), Department of Rheumatology, Departement of Rheumatology and Immunology, Hefei (Anhui Provincial Hospital), Rheumatology Unit (Rheum Unit - PISA), University of Pisa - Università di Pisa, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Department of Clinical Immunology and Rheumatology, Vellore (Christian Medical College & Hospital), Rheumatology Clinic, Udine (DSMB), UO Complessa Reumatologia, Rome, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Division of Rheumatology, Seoul (Department of Internal Medicine), Unit of Experimental Rheumatology, Stockhom (Department of Medicine), University Medical Center, Hôpital Lariboisière, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University and Azienda Ospedaliera of Perugia, Vall d'Hebron University Hospital [Barcelona], The Queen Elizabeth Hospital, Adelaide, Department of Rheumatology, Skane University Hospital, Division of Rheumatology Kanazawa University Graduate School of Medicine, Kanazawa, Centre for Rheumatology - London, Department of Medicine, Universidade Federal do Espirito Santo, Vitoria, Wroclaw Medical University, Uppsala University, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), University of Groningen [Groningen], Department of Immunology and Rheumatology, Nagasaki, Japan, University of L'Aquila [Italy] (UNIVAQ), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), University of Freiburg [Freiburg], Queen Mary University London, Federal University of Sao Paulo (Unifesp), University of Bergen (UiB), Rheumatology Division, Hospital das Clinicas, Sao Paulo (HCFMUSP), Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Rheumatology Department, Cairo, Messina and Milan Univ, Milan, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Rheumatology, Buenos Aires, Department of Immunology [Debrecen, Hungary], Clinical Immunology & Rheumatology, Vellore, Department of Medical Area, University Hospital Santa Maria della Misericordia, Udine, Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Physics Department,Rome University 'LaSapienza' (Physics Department,Rome University 'LaSapienza'), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Department of Immunology [Mexico City], Natl Inst Pediat, Immunodeficiencies Res Unit, Mexico City, DF, Mexico, Rheumatology, Hacetttepe University Faculty of Medicine, Ankara, Laboratoire d'Immunologie [AP-HP Hôpital Kremlin-Bicêtre] (GHU Paris-Sud), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Translational Immunology Groningen (TRIGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Wrocław Medical University, Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Universidad de Córdoba = University of Córdoba [Córdoba], Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), and Michel, Geneviève
Subjects: Male, Systemic disease, [SDV]Life Sciences [q-bio], Disease, primary Sjogren's syndrome, Severity of Illness Index, DISEASE, Cohort Studies, geoepidemiology, 0302 clinical medicine, Epidemiology, gender, Medicine, VASCULITIS, CRITERIA, Pharmacology (medical), Registries, African american, 0303 health sciences, Hispanic or Latino, ethnicity, phenotype, primary Sjögren's syndrome, Middle Aged, 3. Good health, [SDV] Life Sciences [q-bio], Sjogren's Syndrome, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Vasculitis, musculoskeletal diseases, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, education, primary Sjögren’s syndrome, DIAGNOSIS, White People, CLASSIFICATION, ethnicity, gender, geoepidemiology, phenotype, primary Sjögren’s syndrome, 03 medical and health sciences, Asian People, Rheumatology, Internal medicine, SCORE, Humans, COHORT, Rheumatology and Autoimmunity, 030304 developmental biology, 030203 arthritis & rheumatology, Reumatologi och inflammation, Information Dissemination, business.industry, MORTALITY, Racial Groups, GEOEPIDEMIOLOGY, AIR-POLLUTION, medicine.disease, Black or African American, Clinical research, Sjogren s, business
Abstract: Objective To characterize the systemic phenotype of primary Sjögren’s syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. Methods The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren’s syndrome from the five continents. Results The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ≥1). Males had a higher mean ESSDAI (8.1 vs 6.0, P 65 years, P Conclusion The systemic phenotype of primary Sjögren’s syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis.
Published: 2020

33. A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis

Author: Guillermo I. Perez-Perez, Martin J. Blaser, Victoria E. Ruiz, Ceren Özkul, Thomas Battaglia, Claire Roubaud-Baudron, Joseph Xu, Ken Cadwell, Hacettepe University = Hacettepe Üniversitesi, New York University School of Medicine, NYU System (NYU), Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux Research In Translational Oncology [Bordeaux] (BaRITOn), Université de Bordeaux (UB)-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle de Gérontologie Clinique [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Hôpital Xavier Arnozan, Skirball Institute of Biomolecular Medicine, New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), New York University Langone Medical Center (NYU Langone Medical Center), WINLAB Rutgers University, Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers)-Rutgers University System (Rutgers), and Roubaud-Baudron, Claire
Subjects: 0301 basic medicine, Pulsed antibiotic treatment, Antibiotics, lcsh:Medicine, Disease, Childhood antibiotic use, Inflammatory bowel disease, chemistry.chemical_compound, Mice, 0302 clinical medicine, Intestinal Mucosa, Genetics (clinical), DSS-induced colitis, medicine.diagnostic_test, Dextran Sulfate, Age Factors, Biodiversity, T-Lymphocytes, Helper-Inducer, Colitis, 3. Good health, Anti-Bacterial Agents, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Molecular Medicine, Disease Susceptibility, Macrolide, medicine.drug, lcsh:QH426-470, medicine.drug_class, Tylosin, digestive system, Permeability, Flow cytometry, 03 medical and health sciences, Immune system, Genetics, medicine, Animals, Molecular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Gastrointestinal microbiota, business.industry, Research, lcsh:R, Amoxicillin, medicine.disease, Gastrointestinal Microbiome, Disease Models, Animal, stomatognathic diseases, lcsh:Genetics, 030104 developmental biology, chemistry, Immunology, Dysbiosis, business, 030217 neurology & neurosurgery
Abstract: Background There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development. Epidemiologic studies provide evidence that early-life antibiotic exposures predispose to inflammatory bowel disease (IBD). Methods By using a murine model of dextran sodium sulfate (DSS)-induced colitis, we evaluated the effect on disease outcomes of early-life pulsed antibiotic treatment (PAT) using tylosin, a macrolide and amoxicillin, a beta-lactam. We evaluated microbiota effects at the 16S rRNA gene level, and intestinal T cells by flow cytometry. Antibiotic-perturbed or control microbiota were transferred to pups that then were challenged with DSS. Results A single PAT course early-in-life exacerbated later DSS-induced colitis by both perturbing the microbial community and altering mucosal immune cell composition. By conventionalizing germ-free mice with either antibiotic-perturbed or control microbiota obtained 40 days after the challenge ended, we showed the transferrable and direct effect of the still-perturbed microbiota on colitis severity in the DSS model. Conclusions The findings in this experimental model provide evidence that early-life microbiota perturbation may increase risk of colitis later in life.
Published: 2020

34. Toward personalization of asthma treatment according to trigger factors

Author: Luis Caraballo, Susanne Greber-Platzer, W. Pohl, Bulent Enis Sekerel, Valérie Siroux, Elena S. Fedenko, Natalia Ilina, Paolo Maria Matricardi, Harald Renz, Petra Pazderova, Zhanat Ispayeva, Elopy Sibanda, Kian Fan Chung, Nikolaos G. Papadopoulos, Hugo Van Bever, Marianne van Hage, Alexander Emelyanov, S. G. Makarova, Roxana S. Bumbacea, Carmen Panaitescu, Erika von Mutius, Faith H. A. Osier, Sebastian L. Johnston, Jin Lyu Sun, Gary W.K. Wong, R S Fassakhov, Ludmila P. Sizyakina, Kristina Borochova, Jiu-Yao Wang, Evgeny Beltyukov, Zhongshan Gao, Kari C. Nadeau, Antonina Karsonova, Marco Idzko, Snezhana Bychkovskaya, A.N. Pampura, Katarzyna Niespodziana, Peter Errhalt, Tatiana Baranovskaya, Dmitry Kudlay, M. Gotua, Natalia Astafyeva, Thomas Schlederer, Marek L. Kowalski, Rezeda Fayzullina, Musa Khaitov, Tetiana Umanets, Ksenja Riabova, Leyla Namazova-Baranova, Pedro Giavina-Bianchi, Ruby Pawankar, Mohamed-Ridha Barbouche, Zsolt Szépfalusi, Sergii Zaikov, Hae-Sim Park, Guillermo Horacio Docena, Irina Evsegneeva, Mihaela Zidarn, Michael Levin, Adnan Custovic, Jean Bousquet, Elena Kovzel, Paul M. O'Byrne, Daria Fomina, Oleksandr Nazarenko, Elena Borzova, Thomas Eiwegger, Olga Naumova, Gunilla Hedlin, Omer Kalayci, Rudolf Valenta, Vanitha Sampath, Angelika Berger, Margarita Vasileva, Alexander Karaulov, Graduate School, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, Salvy-Córdoba, Nathalie, Medizinische Universität Wien = Medical University of Vienna, Saratov State Medical University, Partenaires INRAE, Belarusian Medical Academy of Post-Graduate Education [Minsk] (BelMAPGE), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), South Ural State Medical University, Russian Medical Academy for Continuous Medical Education [Moscow], Pirogov Russian National Research Medical University, Sechenov First Moscow State Medical University, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Humboldt University Of Berlin, Berlin Institute of Health (BIH), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Krasnoyarsk State Medical University (KrasSMU), Universidad de Cartagena [Cartagena de Indias], National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Universidad Nacional de la Plata [Argentine] (UNLP), The Hospital for sick children [Toronto] (SickKids), North-Western State Medical University [St Petersburg, Russia], Krems University Hospital, Kazan Federal University (KFU), Bashkir State University (BASHEDU), NRC Institute of immunology FMBA, Moscow Russian federation, Zhejiang Gongshang University [Hangzhou] (ZJSU), Universidade de São Paulo = University of São Paulo (USP), Tbilisi State University, Astrid Lindgren Children's Hospital, Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Al-Farabi Kazakh National University [Almaty] (KazNU), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Nazarbayev University [Kazakhstan], Medical University of Łódź (MUL), University of Cape Town, Dmitry Rogachev National Research Center of Pediatric Hematology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Sean N. Parker Center for Allergy and Asthma Research [Stanford], Stanford Medicine, Stanford University-Stanford University, Pirogov Russian National Reasearch Medical University Moscow, National Academy of Medical Sciences of Ukraine, Shupyk National Medical Academy of Postgraduate Education [Kiev] (SNMAPE), Michael DeGroote School of Medicine [Hamilton, ON, Canada], Faculty of Health Sciences [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-McMaster University [Hamilton, Ontario], KEMRI-Wellcome Trust Research Programme (KWTRP), Pius Branzeu Clinical Emergency Hospital (OncoGen), University of Manchester [Manchester], National and Kapodistrian University of Athens (NKUA), Ajou University, Nippon Medical School [Tokyo, Japon], Hietzing Hospital, Karl Landsteiner Institute for Dermatological Research, Landesklinikum St. Poelten, University of Giessen and Marburg Lung Center [Gießen, Germany] (UGMLC), German Center for Lung Research, University of Zimbawe [Harare] (UZ), University of Zimbawe, National University of Science and Technology [Bulawayo], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Southern Federal University [Rostov-on-Don] (SFEDU), Peking Union Medical College Hospital [Beijing] (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, National University of Singapore (NUS), Center of Allergology and Clinical Immunology, Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Helmholtz Centre Munich, German Centre for Lung Research, National Cheng Kung University Hospital [Tainan], The Chinese University of Hong Kong [Hong Kong], Respiratory and Allergic Diseases [Golnik, Slovenia], University Clinic of Respiratory and Allergic Diseases Golnik, University of Ljubljana, and Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria]
Subjects: 0301 basic medicine, Allergy, MESH: Asthma, Rhinovirus, Asthma treatment, CHILDREN, EPITOPE, Disease, Microarray, medicine.disease_cause, sopenje, alergeni, Personalization, Atopy, 0302 clinical medicine, immune system diseases, astma, Immunology and Allergy, MESH: Animals, Precision Medicine, RISK, MESH: Rhinovirus, respiratorni znaki in simptomi, analiza mikromrež, Allergen, alergija in imunologija, SENSITIZATION, personalizirana medicina, Wheeze, rhinovirus, allergy and immunology, INFECTIONS, 1107 Immunology, wheeze, ATOPY, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.symptom, Life Sciences & Biomedicine, Bioquímica, medicine.medical_specialty, MESH: Allergens, [SDV.IMM] Life Sciences [q-bio]/Immunology, precision medicine, Immunology, udc:616-097, MESH: Precision Medicine, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, rinovirus, medicine, Animals, Humans, allergens, IMMUNOTHERAPY, Intensive care medicine, Asthma, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Science & Technology, business.industry, Allergens, asthma, respiratory, medicine.disease, respiratory tract diseases, signs and symptoms, 030104 developmental biology, ANTIBODY, 030228 respiratory system, Ciencias Médicas, MESH: Biomarkers, microarray analysis, business, Biomarkers, RESPONSES
Abstract: Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas
Published: 2020

35. ATP8A2-related disorders as recessive cerebellar ataxia

Author: Ibrahim Oncel, Haluk Topaloglu, Kristin Baraῆano, Robert S. Molday, Mireille Claustres, Lise Larrieu, Patrick Calvas, Maria Iascone, Romano Tenconi, Anna Chassevent, Michel Koenig, Mehdi Benkirane, Nesibe Eroglu-Ertugrul, Elif Acar Arslan, Alexander N Harrison, Claire Guissart, Salvy-Córdoba, Nathalie, Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques (LGMR), Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of British Columbia (UBC), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Karadeniz Technical University (KTU), Kennedy Krieger Institute [Baltimore], ASST Papa Giovanni XXIII [Bergamo, Italy], Università degli Studi di Padova = University of Padua (Unipd), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), IFR3, Université Montpellier 1 (UM1)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universita degli Studi di Padova, Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]
Subjects: Male, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, P4-ATPase, Psychomotor delay, Consanguinity, 0302 clinical medicine, MESH: Child, Missense mutation, 030212 general & internal medicine, Phospholipid Transfer Proteins, Child, Adenosine Triphosphatases, MESH: Phospholipid Transfer Proteins, MESH: Infant, Hypotonia, Pedigree, MESH: Cerebellar Ataxia, 3. Good health, Phenotype, Neurology, Child, Preschool, Female, Cerebellar atrophy, medicine.symptom, Adult, medicine.medical_specialty, Ataxia, Cerebellar Ataxia, MESH: Pedigree, Encephalopathy, Mutation, Missense, Genes, Recessive, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, MESH: Phenotype, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Atrophy, Internal medicine, MESH: Adenosine Triphosphatases, medicine, Humans, Point Mutation, MESH: Genes, Recessive, MESH: Point Mutation, MESH: Consanguinity, MESH: Mutation, Missense, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Cerebellar ataxia, business.industry, MESH: Child, Preschool, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Infant, MESH: Adult, Chorea, medicine.disease, MESH: Male, ATP8A2, Endocrinology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, CAMRQ, Neurology (clinical), business, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; ATP8A2-related disorders are autosomal recessive conditions that associate encephalopathy with or without hypotonia, psychomotor delay, abnormal movements, chorea, tremor, optic atrophy and cerebellar atrophy (CARMQ4). Through a multi-centric collaboration, we identified six point mutations (one splice site and five missense mutations) involving ATP8A2 in six individuals from five families. Two patients from one family with the homozygous p.Gly585Val mutation had a milder presentation without encephalopathy. Expression and functional studies of the missense mutations demonstrated that protein levels of four of the five missense variants were very low and lacked phosphatidylserine-activated ATPase activity. One variant p.Ile215Leu, however, expressed at normal levels and displayed phospholipid-activated ATPase activity similar to the non-mutated protein. We therefore expand for the first time the phenotype related to ATP8A2 mutations to less severe forms characterized by cerebellar ataxia without encephalopathy and suggest that ATP8A2 should be analyzed for all cases of syndromic or non-syndromic recessive or sporadic ataxia.
Published: 2019

36. Progress in conducting polymers for biointerfacing and biorecognition applications

Author: Ali Maziz, Erdoğan Özgür, Christian Bergaud, Lokman Uzun, Équipe Microsystèmes électromécaniques (LAAS-MEMS), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Hacettepe University = Hacettepe Üniversitesi, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), and Université de Toulouse (UT)
Subjects: Conductive polymers, Materials science, QA71-90, Biocompatibility, Mechanotransduction, [SDV]Life Sciences [q-bio], Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Instruments and machines, [SPI]Engineering Sciences [physics], Computer Science (miscellaneous), Tissue engineering, Electrical and Electronic Engineering, Instrumentation, Conductive polymer, Bioelectronics, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Molecularly imprinted polymers, Surface modification, 0210 nano-technology, Neural interface, Biosensor, Electronic materials
Abstract: International audience; Conducting polymers are an exciting class of organic electronic materials, which have attracted an increasing interest in the fields of bioelectronics and their biomedical applications. Their unique features such as mixed ionic-electronic conductivity, good biocompatibility, as well as mechanical softness make them favored candidates for an effective conduit between the worlds of electronics and biology. In addition, the facile synthesis, simple functionalization, and ability to electronically control a range of physical and chemical properties of these materials has enabled considerable development for biorecognition and biosensors devices. In this review, we have turned our attention to recent progress in the tailoring of the conducting polymers functionalities, focusing especially on neural interfaces, molecularly imprinted conducting polymers for biorecognition and bioactive scaffolds for mechanotransduction in living cells.
Published: 2021

37. Respective roles of non-pharmaceutical interventions in bronchiolitis outbreaks: an interrupted time-series analysis based on a multinational surveillance system

Author: Lea, Lenglart, Naim, Ouldali, Kate, Honeyford, Zsolt, Bognar, Silvia, Bressan, Danilo, Buonsenso, Liviana, Da Dalt, Tisham, De, Ruth, Farrugia, Ian K, Maconochie, Henriette A, Moll, Rianne, Oostenbrink, Niccolo, Parri, Damian, Roland, Katy, Rose, Esra, Akyüz Özkan, François, Angoulvant, Camille, Aupiais, Clarissa, Barber, Michael, Barrett, Romain, Basmaci, Susana, Castanhinha, Antonio, Chiaretti, Sheena, Durnin, Patrick, Fitzpatrick, Laszlo, Fodor, Borja, Gomez, Susanne, Greber-Platzer, Romain, Guedj, Florian, Hey, Lina, Jankauskaite, Daniela, Kohlfuerst, Ines, Mascarenhas, Anna Maria, Musolino, Zanda, Pučuka, Sofia, Reis, Alexis, Rybak, Petra, Salamon, Matthias, Schaffert, Keren, Shahar-Nissan, Maria Chiara, Supino, Ozlem, Teksam, Caner, Turan, Roberto, Velasco, Ruud G, Nijman, Luigi, Titomanlio, Vanda, Anacleto, Orkun, Aydin, Elena, Bellelli, Ron, Berant, Thibault, De Groc, Sara, Geitoeira, Florian, Hoffmann, Franziska, Leeb, Fiona, Leonard, Mark, Lyttle, Lia, Mano, Vytenis, Masillonis, Rosa, Morello, Francisa, Saraiva, Gabor, Simon, Ines Silva, Costa, Joao Sous, Marques, Jonas, Thüminger, Corinne, Vasilico, Anna Chiara, Vittucci, Christoph, Zurl, Pediatrics, Business Economics, Hôpital Robert Debré, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Sainte Justine [Montréal], Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), The institute of cancer research [London], Pál Heim Children's Hospital = Heim Pál Gyermekkórház [Budapest], Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Imperial College London, Mater Dei Hospital [Malta], St Mary's Hospital [London], Hammersmith Hospital NHS Imperial College Healthcare, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Azienda Ospedaliero Universitaria A. Meyer [Firenze, Italy], University of Leicester, University Hospitals Leicester, Ondokuz Mayis University (OMU), Université Paris Cité (UPCité), AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Jean Verdier [AP-HP], North Bristol NHS Trust [Bristol, UK], Children's Health Ireland [Crumlin, Dublin, Ireland] (CHI), University College Dublin [Dublin] (UCD), Hôpital Louis Mourier - AP-HP [Colombes], Centro Hospitalar de Lisboa Central E.P.E, CHI at Tallaght Children's Outpatient and Emergency Care Unit [Tallaght, Ireland] (COECU), CHI at Temple Street [Temple Street, Ireland] (TS), Fejér County Szent György University Teaching Hospital [Szekesfehervar, Hungary] (FCSGUTH), Hospital Universitario Cruces = Cruces University Hospital, Medizinische Universität Wien = Medical University of Vienna, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Ludwig-Maximilians University [Munich] (LMU), Hospital of Lithuanian University of Health Sciences Kauno Klinikos [Kaunas, Lithuania], Medical University of Graz, Hospital Prof Doutor Fernando Fonseca [Amadora, Portugal], Bambino Gesù Children’s Hospital [Rome, Italy], Children's Clinical University Hospital [Riga, Latvia] (CCUH), Centro Hospitalar Tondela-Viseu [Viseu, Portugal] (CHTV), Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Schneider Children’s Medical Center [Petah Tikva, Israel] (SCMC), Hacettepe University = Hacettepe Üniversitesi, Mersin University, Rio Hortega University Hospital (Hospital Universitario Río Hortega) [Valladolid, Spain] (RHUH), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), EPISODES Study Group., and Angoulvant, François
Subjects: [SDV] Life Sciences [q-bio], Pulmonary and Respiratory Medicine, SDG 3 - Good Health and Well-being, [SDV]Life Sciences [q-bio]
Abstract: BackgroundBronchiolitis is a major source of morbimortality among young children worldwide. Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of severe acute respiratory syndrome coronavirus 2 may have had an important impact on bronchiolitis outbreaks, as well as major societal consequences. Discriminating between their respective impacts would help define optimal public health strategies against bronchiolitis. We aimed to assess the respective impact of each NPI on bronchiolitis outbreaks in 14 European countries.MethodsWe conducted a quasi-experimental interrupted time-series analysis based on a multicentre international study. All children diagnosed with bronchiolitis presenting to the paediatric emergency department of one of 27 centres from January 2018 to March 2021 were included. We assessed the association between each NPI and change in the bronchiolitis trend over time by seasonally adjusted multivariable quasi-Poisson regression modelling.ResultsIn total, 42 916 children were included. We observed an overall cumulative 78% (95% CI −100– −54%; pConclusionsSeveral NPIs were associated with a reduction of bronchiolitis outbreaks, including full lockdown, school closure, teleworking and facial masking. Some of these public health interventions may be considered to further reduce the global burden of bronchiolitis.
Published: 2022

38. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

Author: Jan Borén, Alberico L. Catapano, Philippe Moulin, Carlos A. Aguilar-Salinas, Anne Tybjærg-Hansen, Sander Kersten, Lale Tokgozoglu, Maurizio Averna, Chris J. Packard, Daniel Gaudet, Henry N. Ginsberg, Brian A. Ference, Gary F. Lewis, Bart Staels, Jane K Stock, Alan T. Remaley, Børge G. Nordestgaard, Alice H. Lichtenstein, M. John Chapman, Robert A. Hegele, Erik S.G. Stroes, Marja-Riitta Taskinen, Columbia University [New York], University of Glasgow, Service d'Endocrinologie, Métabolisme et Prévention des Maladies Cardio-vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM), University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Tecnológico de Monterrey (ITESM), Università degli studi di Palermo - University of Palermo, University of Cambridge [UK] (CAM), Université de Montréal (UdeM), Schulich School of Medicine and Dentistry, University of Western Ontario (UWO), Wageningen University and Research [Wageningen] (WUR), University of Toronto, Tufts University School of Medicine [Boston], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Copenhagen University Hospital, University of Copenhagen = Københavns Universitet (UCPH), National Institutes of Health [Bethesda] (NIH), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires (RNMCD - U1011), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Hacettepe University = Hacettepe Üniversitesi, Rigshospitalet [Copenhagen], Herlev and Gentofte Hospital, European Atherosclerosis Society [Göteborg, Sweden] (EAS), Università degli Studi di Milano = University of Milan (UNIMI), IRCCS Multimedica, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Gestionnaire, HAL Sorbonne Université 5, Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], University of Copenhagen = Københavns Universitet (KU), University of Helsinki, Università degli Studi di Milano [Milano] (UNIMI), Ginsberg, Henry N, Packard, Chris J, Chapman, M John, Borén, Jan, Aguilar-Salinas, Carlos A, Averna, Maurizio, Ference, Brian A, Gaudet, Daniel, Hegele, Robert A, Kersten, Sander, Lewis, Gary F, Lichtenstein, Alice H, Moulin, Philippe, Nordestgaard, Børge G, Remaley, Alan T, Staels, Bart, Stroes, Erik S G, Taskinen, Marja-Riitta, Tokgözoğlu, Lale S, Tybjaerg-Hansen, Anne, Stock, Jane K, Catapano, Alberico L, Clinicum, Marja-Riitta Taskinen Research Group, CAMM - Research Program for Clinical and Molecular Metabolism, HUS Helsinki and Uusimaa Hospital District, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD)
Subjects: CHOLESTERYL ESTER TRANSFER, TO-MODERATE HYPERTRIGLYCERIDEMIA, Lipoprotein remnants, 030204 cardiovascular system & hematology, Bioinformatics, Residual risk, Brain Ischemia, chemistry.chemical_compound, Voeding, Metabolisme en Genomica, 0302 clinical medicine, Ischaemic stroke, AcademicSubjects/MED00200, Myocardial infarction, LOW-GRADE INFLAMMATION, ALL-CAUSE MORTALITY, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 0303 health sciences, Atherosclerotic cardiovascular disease, digestive, oral, and skin physiology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Cardiovascular disease, Metabolism and Genomics, 3. Good health, Stroke, LOW-DENSITY LIPOPROTEINS, Cardiovascular Diseases, Metabolisme en Genomica, CORONARY-ARTERY-DISEASE, Nutrition, Metabolism and Genomics, Cardiology and Cardiovascular Medicine, B-CONTAINING LIPOPROTEINS, Lipoproteins, Triglyceride-rich lipoproteins, HEART-DISEASE, 03 medical and health sciences, Special Article, Voeding, medicine, Humans, HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, Triglycerides, 030304 developmental biology, Nutrition, VLAG, Triglyceride, business.industry, APO-B, medicine.disease, Atherosclerosis, Increased risk, chemistry, 3121 General medicine, internal medicine and other clinical medicine, European atherosclerosis society, business, Lipoprotein
Abstract: Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and increased risk of myocardial infarction, ischaemic stroke, and aortic valve stenosis. These data also indicate that TRL and their remnants may contribute significantly to residual cardiovascular risk in patients on optimized low-density lipoprotein (LDL)-lowering therapy. This statement critically appraises current understanding of the structure, function, and metabolism of TRL, and their pathophysiological role in atherosclerotic cardiovascular disease (ASCVD). Key points are (i) a working definition of normo- and hypertriglyceridaemic states and their relation to risk of ASCVD, (ii) a conceptual framework for the generation of remnants due to dysregulation of TRL production, lipolysis, and remodelling, as well as clearance of remnant lipoproteins from the circulation, (iii) the pleiotropic proatherogenic actions of TRL and remnants at the arterial wall, (iv) challenges in defining, quantitating, and assessing the atherogenic properties of remnant particles, and (v) exploration of the relative atherogenicity of TRL and remnants compared to LDL. Assessment of these issues provides a foundation for evaluating approaches to effectively reduce levels of TRL and remnants by targeting either production, lipolysis, or hepatic clearance, or a combination of these mechanisms. This consensus statement updates current understanding in an integrated manner, thereby providing a platform for new therapeutic paradigms targeting TRL and their remnants, with the aim of reducing the risk of ASCVD., Graphical Abstract Formation of triglyceride-rich lipoprotein remnants and their role in atherogenesis. Metabolic scheme for the generation and clearance of triglyceride-rich lipoprotein remnant particles (A). In hypertriglyceridaemia, overproduction and inefficient lipolysis of both very low-density lipoprotein and chylomicrons lead to increased remnant formation. Triglyceride-rich lipoprotein remnants contribute to the initiation and progression of atherosclerotic lesions (B). Particle retention in the subendothelial space is followed by inflammation, cholesterol deposition, and macrophage foam cell formation.
Published: 2021

39. Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC: Results From the Phase 3 TAHOE Study

Author: Ilié, Marius, Mazières, Julien, Chamorey, Emmanuel, Heeke, Simon, Benzaquen, Jonathan, Thamphya, Brice, Boutros, Jacques, Tiotiu, Angélica, Fayada, Julien, Cadranel, Jacques, Poudenx, Michel, Moro-Sibilot, Denis, Barlesi, Fabrice, Thariat, Juliette, Clément-Duchêne, Christelle, Tomasini, Pascale, Hofman, Véronique, Marquette, Charles-Hugo, Hofman, Paul, Israel-Biet, Dominique, Pison, Christophe, Lantuejoul, Sylvie, Stephanov, Olivier, Juliette, Meyzenc, Mendozat, Christophe, Zaidi, Manel, Coulouvrat, Sandra, Col, Edwige, Chanez, Pascal, Greillier, Laurent, Mascaux, Céline, Jourdan, Sandrine, Roger, Aurélie, Biemar, Julie, Randriamampionona, Rondro, Chabot, François, Vignaud, Jean-Michel, Lacomme, Stéphanie, Lomazzi, Sandra, Laurent, Carine, Bulsei, Xavier, Bischoff, Laura, Rakotonirina, Raymond, Layouni, Mehdi, Deslee, Gaëtan, Mal, Hervé, Kessler, Romain, Vergnon, Jean-Michel, Pelissier, Isabelle, Cuvelier, Antoine, Bourdin, Arnaud, Jounieaux, Vincent, Roche, Nicolas, Jouneau, Stéphane, Bonniaud, Philippe, Scherpereel, Arnaud, Mornex, Jean François, Steenhouwer, François, Leroy, Sylvie, Marquette, Charles Hugo, Mazzette, Andrea, Padovani, Bernard, Long-Mira, Elodie, Lassalle, Sandra, Pradelli, Johanna, Martinez, Estelle, Habault, Marine, Bonnard, Mélanie, Moutarde, Julie, Yatimi, Rachida, Labsi, Hakima, Gazoppi, Loïc, Lpce, Tumorothèque, Griffonnet, Jennifer, Fontaine, Maureen, Guillemart, Ariane, Butori, Catherine, Selva, Eric, Otto, Josiane, Hebert, Christophe, Botchiellini, Delphine, Boudouf, Soukaina, Menier, Margaux, Occeli, Estelle, Bellentani, Sophie, Pion, Carine, Fournier, Elodie, Gervais, Radj, Hamond, Karim, Marchand-Adam, Sylvain, Plantier, Laurent, Fajolle, Gaelle, Rayez, Mélanie, Fallet, Vincent, Wislez, Marie, Antoine, Martine, Cote, Jean-François, Chaabane, Nouha, Ruppert, Anne Marie, Bertrand, Eliane, Rodenas, Anita, Pontdeme, Gwenaëlle, Mathiot, Nathalie, Ribert, Tamazouzt, Guibert, Nicolas, Rouviere, Damien, Bousquet, Emilie, Bigay-Game, Laurence, Hermant, Christophe, Plat, Gavin, Rouquette, Isabelle, Evrard, Solène, Gouin, Sandrine, Clermont, Estelle Taranchon, Dormoy, Inge, Coulomb, Christelle, Pradine, Anne, Lambert, Véronique, Laborde, Lilian, Castelnau, Olivier, University of Manchester [Manchester], Hôpital du Sacré-Coeur de Montréal, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Yonsei University College of Medicine [Séoul, Corée du Sud], August Pi i Sunyer Biomedical Research Institute - IDIBAPS [Barcelona, Spain], Hospital de la Santa Creu i Sant Pau, University Hospitals Leuven [Leuven], National and Kapodistrian University of Athens (NKUA), Odense University Hospital (OUH), Oregon Health and Science University [Portland] (OHSU), Kyushu University, Hacettepe University = Hacettepe Üniversitesi, University of Copenhagen = Københavns Universitet (UCPH), University of Groningen [Groningen], Abbvie Inc. [North Chicago], Asklepios Klinikum Uckermark GmbH, Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes
Subjects: 0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, medicine.medical_treatment, CELL LUNG-CANCER, Population, Peripheral edema, Phases of clinical research, [SDV.CAN]Life Sciences [q-bio]/Cancer, Delta-like protein 3, Rovalpituzumab tesirine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, DRUG, education, ComputingMilieux_MISCELLANEOUS, Chemotherapy, education.field_of_study, Small cell lung cancer, business.industry, Hazard ratio, Confidence interval, 030104 developmental biology, 030220 oncology & carcinogenesis, Topotecan, medicine.symptom, business, medicine.drug
Abstract: INTRODUCTION: DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate containing a DLL3-targeting antibody tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. The efficacy and safety of Rova-T compared with topotecan as second-line therapy in patients with SCLC expressing high levels of DLL3 (DLL3-high) was evaluated. METHODS: The TAHOE study was an open-label, two-to-one randomized, phase 3 study comparing Rova-T with topotecan as second-line therapy in DLL3-high advanced or metastatic SCLC. Rova-T (0.3 mg/kg) was administered intravenously on day 1 of a 42-day cycle for two cycles, with two additional cycles available to patients who met protocol-defined criteria for continued dosing. Topotecan (1.5 mg/m2) was administered intravenously on days 1 to 5 of a 21-day cycle. The primary end point was overall survival (OS). RESULTS: Patients randomized to Rova-T (n = 296) and topotecan (n = 148) were included in the efficacy analyses. The median age was 64 years, and 77% had the extensive disease at initial diagnosis. The median OS (95% confidence interval) was 6.3 months (5.6-7.3) in the Rova-T arm and 8.6 months (7.7-10.1) in the topotecan arm (hazard ratio, 1.46 [95% confidence interval: 1.17-1.82]). An independent data monitoring committee recommended that enrollment be discontinued because of the shorter OS observed with Rova-T compared with topotecan. Safety profiles for both drugs were consistent with previous reports. CONCLUSIONS: Compared with topotecan, which is the current standard second-line chemotherapy, Rova-T exhibited an inferior OS and higher rates of serosal effusions, photosensitivity reaction, and peripheral edema in patients with SCLC. A considerable unmet therapeutic need remains in this population. ispartof: JOURNAL OF THORACIC ONCOLOGY vol:16 issue:9 pages:1547-1558 ispartof: location:United States status: published
Published: 2021

40. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

Author: Marie-France Deguilloux, Agata Hałuszko, Maïté Rivollat, Sandra Penske, J. S. Díaz, Michal Ernée, Eirini Skourtanioti, Miroslav Dobeš, Cosimo Posth, Mario Küßner, Stéphane Rottier, Gunnar U. Neumann, Emmanuel Ghesquière, Susanne Friederich, Yılmaz Selim Erdal, Adam Ben Rohrlach, Rana Özbal, Svend Hansen, Marcella Frangipane, Marcello A. Mannino, Ainash Childebayeva, Consuelo Roca de Togores Muñoz, Sabine Reinhold, Murat Akar, Wolfgang Haak, Alexander Herbig, Luka Papac, Yavor Boyadzhiev, Domingo C. Salazar-García, Vanessa Villalba-Mouco, Kamen Boyadzhiev, Johannes Krause, K. Aslıhan Yener, Mirosław Furmanek, Marieke Sophia van de Loosdrecht, Philipp W. Stockhammer, European Commission, Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, University of Adelaide, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Spanish National Research Council (CSIC), Mustafa Kemal University, Bulgarian Academy of Sciences (BAS), Czech Academy of Sciences [Prague] (CAS), Hacettepe University = Hacettepe Üniversitesi, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Wrocław [Poland] (UWr), State Office for Heritage Management and Archaeology Saxony-Anhalt - State Museum of Prehistory, Institut national de recherches archéologiques préventives (Inrap), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Nantes Université (NU), German Archaeological Institute (DAI), Aarhus University [Aarhus], Koç University, Basque Foundation for Science (Ikerbasque), University of Cape Town, Departamento de Inteligencia Artificial [UPM, Spain] (DIA), Universidad Politécnica de Madrid (UPM), Universitat de València (UV), Medizinische Klinik und Poliklinik III [Bonn, Germany], Universitätsklinikum Bonn (UKB), MARQ - Museo Arqueológico Provincial de Alicante (MARQ), Ludwig Maximilian University [Munich] (LMU), New York University [New York] (NYU), NYU System (NYU), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, University of South Australia [Adelaide], Max Planck Society Foundation CELLEX, French (ANR) French National Research Agency (ANR), German (DFG) Research Foundations under the INTERACT project German Research Foundation (DFG) [ANR17-FRAL-0010, DFG-HA-5407/4-1], European Research Council (ERC) under the European Union European Research Council (ERC) [771234-PALEoRIDER], Czech Academy of Sciences Czech Academy of Sciences, Institute of Archaeology of the Czech Academy of Sciences, Prague Czech Academy of Sciences [RVO 67985912], Projekt DEAL, ANR-17-FRAL-0010,INTERACT,Interactions entre groupes humains en Europe de l'Ouest durant la transition Mésolithique-Néolithique: la double perspective des échanges biologiques et culturels(2017), Özbal, Rana (ORCID 0000-0001-6765-2765 & YÖK ID 55583), Rohrlach, A.B., Papac, L., Childebayeva, A., Rivollat, M., Villalba Mouco, V., Neumann, G.U., Penske, S., Skourtanioti, E., van de Loosdrecht, M., Akar, M., Boyadzhiev, K., Boyadzhiev, Y., Deguilloux, M.F., Dobes, M., Erdal, Y.S., Ernée, M., Frangipane, M., Furmanek, M., Friederich, S., Ghesquière, E., Ha?uszko, A., Hansen, S., Küßner, M., Mannino, M., Reinhold, S., Rottier, S., Salazar García, D.C., Diaz, J.S., Stockhammer, P.W., de Togores Muñoz, C.R., Yener, K.A., Posth, C., Krause, J., Herbig, A., Haak, W., College of Social Sciences and Humanities, Department of Archeology and History of Art, Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Université de Nantes (UN)-Le Mans Université (UM)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), Université de Nantes (UN)-Université de Nantes (UN)-Ministère de la Culture (MC), Max Planck Society, Agence Nationale de la Recherche (France), German Research Foundation, European Research Council, Academy of Sciences of the Czech Republic, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), and Ikerbasque - Basque Foundation for Science
Subjects: Czech, SELECTION, Population genetics, MITOCHONDRIAL-DNA, early farmers, DIVERSITY, mitochondrial DNA, shotgun sequencing, Prehistòria, Haplogroup, German, 0302 clinical medicine, Medicine and Health Sciences, DNA sequencing, Science and technology, media_common, 0303 health sciences, Multidisciplinary, Horizon (archaeology), Critical event, Shotgun sequencing, chromosomal haplogroups, European research, STEPPE, Western europe, language, Medicine, Genetic Markers, Mitochondrial DNA, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, uniparentally-inherited markers, Science, Library science, Biology, Y chromosome, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Target enrichment, Article, 03 medical and health sciences, Political science, Humans, media_common.cataloged_instance, ANCIENT DNA, Genetic Testing, European union, Alleles, 030304 developmental biology, MUTATION-RATE, Chromosomes, Human, Y, Saturation (genetic), History and Archaeology, Y-mappable capture assay, Ancient DNA, Neanderthals, Anatomically modern humans, language.human_language, Neolithic transition, Genetics, Population, Haplotypes, Evolutionary biology, GENOMIC HISTORY, 030217 neurology & neurosurgery
Abstract: Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the "mappable" regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe., Open Access funding enabled and organized by Projekt DEAL. This study was funded by the Max Planck Society, the French (ANR) and German (DFG) Research Foundations under the INTERACT project (ANR-17-FRAL-0010, DFG-HA-5407/4-1, 2018-2021) to M.R. and W.H., the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under Grant agreement no. 771234-PALEoRIDER to W.H., the award Praemium Academiae of the Czech Academy of Sciences to M.E. and the project RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences, Prague to M.S.
Published: 2021

41. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author: Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, Giorgio Walter, Chivato, Tomas, Al-Ahmad, Mona, Rasib, A. H. Abdul, Ansotegui, Ignacio J, Bachert, Claus, Soto-Martinez, Manuel, Laune, Daniel, Casale, Tomas, Levin, Michael, Larenas-Linnemann, Désirée, Samolinski, Boleslaw, Lodrup Carlsen, Karin C, O'Mahony, Liam, Lombardi, Carlo, Riggioni, Carmen, Hossny, Elham, Barata, Luís Taborda, Lourenço, Olga, Devillier, Philippe, Mahboub, Bassam, Malling, Hans-Jørgen, Sheikh, Aziz, Manning, Patrick, Passalacqua, Giovanni, Marshall, Gailen D, Sanchez-Borges, Mario, Toppila-Salmi, Sanna, Melén, Erik, Fokkens, Wytske J, Meltzer, Eli O, Miculinic, Neven, Soto-Quiros, Manuel, Milenkovic, Branislava, Roberts, Graham, Ohta, Ken, Scichilone, Nicola, Moin, Mostafa, Odemyr, Mikaëla, Montefort, Stephen, Almeida, Mário Morais, Bom, Ana Todo, Mortz, Charlotte G, Serpa, Faradiba S, Patella, Vincenzo, Sova, Milan, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Tsiligianni, Ioanna, Neffen, Hugo, Bjermer, Leif, Rodriguez-Gonzales, Monica, Torres, Maria J, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Baharuddin, Abdullah, Cecchi, Lorenzo, Sastre, Joaquin, Untersmayr, Eva, Pawankar, Ruby, Pham-Thi, Nhân, Plavec, Davor, Cardona, Victoria, Dokic, Dejan, Sisul, Juan Carlos, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Del Giacco, Stefano, Fonseca, Joao A, Schwarze, Jürgen, Scadding, Glenis K, Shamji, Mohamed H, Schmid-Grendelmeier, Peter, Niedoszytko, Marek, Valentin-Rostan, Marylin, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Palkonen, Susanna, Urrutia-Pereira, Marilyn, Skypala, Isabel, Suppli-Ulrik, Charlotte, Bonini, Matteo, Popov, Todor A, Tomazic, Peter-Valentin, Valero, Antonio, Cepeda Sarabia, Alfonso M, Ryan, Dermot, Bosnic-Anticevich, Sinthia, Valiulis, Arunas, Durham, Stephen L, Schünemann, Holger, Kalayci, Omer, Valovirta, Erkka, Panzner, Petr, Vandenplas, Olivier, Ventura, Maria Teresa, Gotua, Maia, Vichyanond, Pakit, Chkhartishvili, Ekaterine, Wagenmann, Martin, Fontaine, Jean-François, Kull, Inger, Wallace, Dana, Recto, Marysia, Walusiak-Skorupa, Jolanta, Wang, De Yun, Hrubiško, Martin, Waserman, Susan, Ebisawa, Motohiro, Bosse, Isabelle, Grisle, Ineta, Wong, Gary Wk, Bindslev-Jensen, Carsten, Yorgancioglu, Arzu, Yusuf, Osman M, Khaitov, Musa, Zernotti, Mario, Gawlik, Radoslaw, Chu, Derek K, Irani, Carla, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Kuna, Piotr, Jutel, Marek, Guzmán, Maria Antonieta, El-Gamal, Yehia, Klimek, Ludger, Brough, Helen A, Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, O'Hehir, Robyn E, Gelincik, Asli, Kvedariene, Violeta, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Nekam, Kristof, Papadopoulos, Nikolaos G., Haahtela, Tari, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Palomares, Oscar, Regateiro, Frederico S, Ivancevich, Juan Carlos, Gemicioglu, Bilun, Gereda, Jose E, Gerth van Wijk, Roy, Bergmann, Karl-Christian, Knol, Edward, Halken, Susanne, Heffler, Enrico, Hoffmann-Sommergruber, Karin, Martins, Pedro Carreiro, Kritikos, Vicky, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Demoly, Pascal, Kowalski, Marek, Kraxner, Helga, Ollert, Markus, Fiocchi, Alessandro, Lauerma, Antti, Lau, Susanne, Park, Hae-Sim, Gomez, R Maximiliano, Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), uBibliorum, Bousquet J., Pfaar O., Agache I., Bedbrook A., Akdis C.A., Canonica G.W., Chivato T., Al-Ahmad M., Abdul Latiff A.H., Ansotegui I.J., Bachert C., Baharuddin A., Bergmann K.-C., Bindslev-Jensen C., Bjermer L., Bonini M., Bosnic-Anticevich S., Bosse I., Brough H.A., Brussino L., Calderon M.A., Caraballo L., Cardona V., Carreiro-Martins P., Casale T., Cecchi L., Cepeda Sarabia A.M., Chkhartishvili E., Chu D.K., Cirule I., Cruz A.A., Czarlewski W., del Giacco S., Demoly P., Devillier P., Dokic D., Durham S.L., Ebisawa M., El-Gamal✝ Y., Emuzyte R., Gamkrelidze A., Fauquert J.L., Fiocchi A., Fokkens W.J., Fonseca J.A., Fontaine J.-F., Gawlik R., Gelincik A., Gemicioglu B., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gotua M., Grisle I., Guzman M.-A., Haahtela T., Halken S., Heffler E., Hoffmann-Sommergruber K., Hossny E., Hrubisko M., Irani C., Ivancevich J.C., Ispayeva Z., Julge K., Kaidashev I., Kalayci O., Khaitov M., Klimek L., Knol E., Kowalski M.L., Kraxner H., Kull I., Kuna P., Kvedariene V., Kritikos V., Lauerma A., Lau S., Laune D., Levin M., Larenas-Linnemann D.E., Lodrup Carlsen K.C., Lombardi C., Lourenco O.M., Mahboub B., Malling H.-J., Manning P., Marshall G.D., Melen E., Meltzer E.O., Miculinic N., Milenkovic B., Moin M., Montefort S., Morais-Almeida M., Mortz C.G., Mosges R., Mullol J., Namazova Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Ollert M., O'Mahony L., Ohta K., Okamoto Y., Okubo K., Pajno G.B., Palomares O., Palkonen S., Panzner P., G Papadopoulos N., Park H.-S., Passalacqua G., Patella V., Pawankar R., Pham-Thi N., Plavec D., Popov T.A., Recto M., Regateiro F.S., Riggioni C., Roberts G., Rodriguez-Gonzales M., Rosario N., Rottem M., Rouadi P.W., Ryan D., Samolinski B., Sanchez-Borges✝ M., Serpa F.S., Sastre J., Scadding G.K., Shamji M.H., Schmid-Grendelmeier P., Schunemann H.J., Sheikh A., Scichilone N., Sisul J.C., Sofiev M., Sole D., Sooronbaev T., Soto-Martinez M., Soto-Quiros M., Sova M., Schwarze J., Skypala I., Suppli-Ulrik C., Taborda-Barata L., Todo-Bom A., Torres M.J., Valentin-Rostan M., Tomazic P.-V., Valero A., Toppila-Salmi S., Tsiligianni I., Untersmayr E., Urrutia-Pereira M., Valiulis A., Valovirta E., Vandenplas O., Ventura M.T., Vichyanond P., Wagenmann M., Wallace D., Walusiak-Skorupa J., Wang D.Y., Waserman S., Wong G.W.K., Yorgancioglu A., Yusuf O.M., Zernotti M., Zhang L., Zidarn M., Zuberbier T., Jutel M., HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Department of Pathology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Philipps Universität Marburg = Philipps University of Marburg, Transilvania University of Brasov, Universität Zürich [Zürich] = University of Zurich (UZH), Humanitas University [Milan] (Hunimed), Universidad San Pablo CEU, Kuwait University, Al-Rashed Allergy Center [Kuwait City], Pantai Hospital [Kuala Lumpur], Hospital Quirónsalud Bizkaia [Bilbao], Ghent University Hospital, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Sun Yat-Sen University [Guangzhou] (SYSU), Universiti Sains Malaysia (USM), Humboldt University Of Berlin, Berlin Institute of Health (BIH), Odense University Hospital (OUH), Skane University Hospital [Lund], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Woolcock Institute of Medical Research [Sydney], The University of Sydney, Guy's and St Thomas' Hospital [London], King‘s College London, Università degli studi di Torino = University of Turin (UNITO), University of Cartagena, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University of South Florida [Tampa] (USF), Azienda Usl Toscana centro [Firenze], Universidad Simon Bolivar (USB), David Tvildiani Medical University (DTMU), McMaster University [Hamilton, Ontario], Children's Clinical University Hospital [Riga, Latvia] (CCUH), Universidade Federal da Bahia (UFBA), Università degli Studi di Cagliari = University of Cagliari (UniCa), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Foch [Suresnes], Sagamihara National Hospital [Kanagawa, Japan], Université Ain Shams, Vilnius University [Vilnius], CHU Clermont-Ferrand, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Universidade do Porto = University of Porto, Silesian Medical University, Katowice, Poland, Cerrahpasa Faculty of Medicine, Istanbul University, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidad de Chile = University of Chile [Santiago] (UCHILE), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Medizinische Universität Wien = Medical University of Vienna, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Tartu University Hospital [Tartu, Estonia], Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Hacettepe University = Hacettepe Üniversitesi, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], Nova Southeastern University (NSU), Nofer Institute of Occupational Medicine (NIOM), National University of Singapore (NUS), Yong Loo Lin School of Medicine [Singapore], The Chinese University of Hong Kong [Hong Kong], Manisa Celal Bayar University, Universidad Nacional de Villa María, Universidad Católica de Córdoba, Beijing Tongren Hospital, Herrada, Anthony, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie
Subjects: Pulmonary and Respiratory Medicine, precision medicine, education, Immunology, Review, Settore MED/10 - Malattie Dell'Apparato Respiratorio, immune system diseases, HDE ALER, allergic rhinitis, asthma, immunotherapy, Medicine and Health Sciences, Immunology and Allergy, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, ComputingMilieux_MISCELLANEOUS, Rhinitis, RC581-607, respiratory tract diseases, 3121 General medicine, internal medicine and other clinical medicine, Immunologic diseases. Allergy, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology, allergic rhinitis, asthma, immunotherapy, precision medicine
Abstract: Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission's Horison's 2020 Framework Programme, Cure, Novartis Research Institutes, Astra Zeneca, scibase, advisory role in Sanofi/Regeneron, grants from Glakso Smith‐Kline, advisory role in scibase. Funding Information: MJTreports grants from European Commission, SEAIC, ISCIII, personal fees from Diater laboratory, Leti laboratory, Aimmune Therapeutics. Funding Information: LK reports grants and personal fees from Allergopharma, MEDA/Mylan, LETI Pharma, Sanofi, grants from Stallergenes, Quintiles, ASIT biotech, grants from ALK Abelló, Lofarma, AstraZeneca, GSK, Inmunotk, personal fees from Allergy Therapeut., HAL Allergie, Cassella med; and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO‐BV, GPA, EAACI. Funding Information: DPreports grants and personal fees from GlaxoSmithKline, personal fees from Menarini, Pliva, Belupo, AbbVie, Novartis, MSD, Chiesi, Revenio, personal fees and non‐financial support from Boehringer Ingelheim, non‐financial support from Philips. Funding Information: OP reports grants and personal fees from ALK‐Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools S.A., Laboratorios LETI/LETI Pharma, Anergis S.A., Glaxo Smith Kline, grants from Biomay, Circassia, Pohl‐Boskamp, Inmunotek S.L., personal fees from MEDA Pharma/MYLAN, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, Astellas Pharma Global, EUFOREA, ROXALL Medizin, Novartis, Sanofi‐Aventis and Sanofi‐Genzyme, Med Update Europe GmbH, streamedup! GmbH, John Wiley and Sons, AS. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. publishersversion published
Published: 2021

42. Delayed hypersensitivity to antiepileptic drugs in children

Author: Sophia Tsabouri, Ozge Soyer, Antonino Romano, Marina Atanaskovic-Markovic, Pascal Demoly, Natalia Blanca-López, Jean-Christoph Roger J-P Caubet, George Du Toit, Eva Rebelo Gomes, Francesca Mori, Semanur Kuyucu, Azienda Ospedaliero Universitaria A. Meyer [Firenze, Italy], Hospital Universitario Infanta Leonor [Madrid], Hôpitaux Universitaires de Genève (HUG), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Montpellier (UM), Evelina London Children's Hospital, King‘s College London, Centro Hospitalar do Porto, Mersin University, Oasi Maria SS Institute, Hacettepe University = Hacettepe Üniversitesi, University of Ioannina, University of Belgrade [Belgrade], Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Herrada, Anthony
Subjects: drug allergy diagnosis, medicine.medical_specialty, Drug discontinuation, medicine.medical_treatment, Immunology, Patch testing, Drug Hypersensitivity, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, children, Risk Factors, In vivo, Humans, Immunology and Allergy, Medicine, Hypersensitivity, Delayed, 030212 general & internal medicine, Granulysin, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Child, Intensive care medicine, Skin, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, ELISPOT, Intradermal testing, Antiepileptic drugs hypersensitivity, Intradermal Tests, medicine.disease, 3. Good health, Anticonvulsant, 030228 respiratory system, Delayed hypersensitivity, Concomitant, Pediatrics, Perinatology and Child Health, Anticonvulsants, business, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Abstract: International audience; Background: Antiepileptic drugs (AEDs) are widely used for the treatment of epilepsy, but they can be associated with the development of mainly delayed/non-immediate hypersensitivity reactions (HRs). Although these reactions are usually cutaneous, self-limited, and spontaneously resolve within days after drug discontinuation, sometime HR reactions to AEDs can be severe and life-threatening.Aim: This paper seeks to show examples on practical management of AED HRs in children starting from a review of what it is already known in literature.Results: Risk factors include age, history of previous AEDs reactions, viral infections, concomitant medications, and genetic factors. The diagnostic workup consists of in vivo (intradermal testing and patch testing) and in vitro tests [serological investigation to exclude the role of viral infection, lymphocyte transformation test (LTT), cytokine detection in ELISpot assays, and granulysin (Grl) in flow cytometry. Treatment is based on a prompt drug discontinuation and mainly on the use of glucocorticoids.Conclusion: Dealing with AED HRs is challenging. The primary goal in the diagnosis and management of HRs to AEDs should be trying to accurately identify the causal trigger and simultaneously identify a safe and effective alternative anticonvulsant. There is therefore an ongoing need to improve our knowledge of HS reactions due to AED medications and in particular to improve our diagnostic capabilities.
Published: 2021

43. Reconsidering the central role of mucins in dry eye and ocular surface diseases

Author: Murat Irkec, Maurizio Rolando, Christophe Baudouin, Gysbert van Setten, Francisco C Figueiredo, Marc Labetoulle, Elisabeth M. Messmer, Jose M. Benitez del Castillo, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Ludwig-Maximilians-Universität München (LMU), Institute of Genetic Medicine [Newcastle], Newcastle University [Newcastle], Faculty of Medicine [Hacettepe University], and Hacettepe University = Hacettepe Üniversitesi
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], Inflammation, Disease, Immune tolerance, Unmet needs, Cornea, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Secretion, business.industry, Mucin, Mucins, eye diseases, Sensory Systems, 3. Good health, Ophthalmology, 030104 developmental biology, Tears, Immunology, 030221 ophthalmology & optometry, Dry Eye Syndromes, Goblet Cells, sense organs, medicine.symptom, business, Conjunctiva, Ocular surface, Homeostasis
Abstract: Mucins are key actors in tear film quality and tear film stability. Alteration of membrane-bound mucin expression on corneal and conjunctival epithelial cells and/or gel-forming mucin secretion by goblet cells (GCs) promotes in ocular surface diseases and dry eye disease (DED). Changes in the mucin layer may lead to enhanced tear evaporation eventually contributing to tear hyperosmolarity which has been associated with ocular surface inflammation. Inflammatory mediators in turn may have a negative impact on GCs differentiation, proliferation, and mucin secretion. This sheds new light on the position of GCs in the vicious circle of DED. As contributor to ocular surface immune homeostasis, GC loss may contribute to impaired ocular surface immune tolerance observed in DED. In spite of this, there are no tools in routine clinical practice for exploring ocular surface mucin deficiency/dysregulation. Therefore, when selecting the most appropriate treatment options, there is a clear unmet need for a better understanding of the importance of mucins and options for their replacement. Here, we comprehensively revisited the current knowledge on ocular surface mucin biology, including functions, synthesis, and secretion as well as the available diagnostic tools and treatment options to improve mucin-associated homeostasis. In particular, we detailed the potential link between mucin dysfunction and inflammation as part of the uncontrolled chronic inflammation which perpetuates the vicious circle in DED.
Published: 2019

44. Comparing patient-perceived and physician-perceived remission and low disease activity in psoriatic arthritis

Author: Uta Kiltz, Adeline Ruyssen-Witrand, Penelope Esther Palominos, Ennio Lubrano, Laura C. Coates, Martin Soubrier, Déborah Puyraimond-Zemmour, Maarten de Wit, Sibel Zehra Aydin, Andra Balanescu, Clémence Gorlier, Inna Gaydukova, Lihi Eder, Umut Kalyoncu, Laure Gossec, Emmanuelle Dernis, Juan D. Cañete, M. Elaine Husni, Sandra Tälli, Ying Ying Leung, Pascal Richette, Josef S Smolen, Ana Maria Orbai, Rossana Scrivo, Sorbonne Université (SU), Johns Hopkins University School of Medicine [Baltimore], University of Oxford [Oxford], Ruhr-Universität Bochum [Bochum], Hospital de Clínicas de Porto Alegre (HCPA), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Médecine Carol Davila, Centre Hospitalier Le Mans (CH Le Mans), CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Service de Rhumatologie [CHU Gabriel-Montpied], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Ottawa Hospital Research Institute [Ottawa] (OHRI), University of Ottawa [Ottawa], University of Toronto, University of Molise [Campobasso] (UNIMOL), University of Molise, Hacettepe University = Hacettepe Üniversitesi, Service de Rhumatologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques (BIOSCAR (UMR_S_1132 / U1132)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cleveland Clinic, VU University Medical Center [Amsterdam], Medizinische Universität Wien = Medical University of Vienna, Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Ethics, Law & Medical humanities, and APH - Health Behaviors & Chronic Diseases
Subjects: Adult, Male, medicine.medical_specialty, Outcome Assessment, Cross-sectional study, Immunology, Psoriatic, disease activity, patient perspective, psoriatic arthritis, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, Disease activity, Diagnostic Self Evaluation, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Rheumatology, Physicians, Internal medicine, Outcome Assessment, Health Care, Severity of illness, medicine, Humans, Immunology and Allergy, In patient, 030212 general & internal medicine, 030203 arthritis & rheumatology, Biological Products, Antirheumatic Agents, Arthritis, Psoriatic, Cross-Sectional Studies, Female, Middle Aged, Remission Induction, Reproducibility of Results, Treatment Outcome, business.industry, Arthritis, Mean age, medicine.disease, 3. Good health, Health Care, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Unselected population, business, Kappa
Abstract: BackgroundThe objective was to compare different definitions of remission and low disease activity (LDA) in patients with psoriatic arthritis (PsA), based on both patients’ and physicians’ perspectives.MethodsIn ReFlap (Remission/Flare in PsA; NCT03119805), adults with physician-confirmed PsA and >2 years of disease duration in 14 countries were included. Remission was defined as very low disease activity (VLDA), Disease Activity index for PSoriatic Arthritis (DAPSA) ≤4, and physician-perceived and patient-perceived remission (specific question yes/no), and LDA as minimal disease activity (MDA), DAPSA ResultsOf 410 patients, the mean age (SD) was 53.9 (12.5) years, 50.7% were male, disease duration was 11.2 (8.2) years, 56.8% were on biologics, and remission/LDA was frequently attained: respectively, for remission from 12.4% (VLDA) to 36.1% (physician-perceived remission), and for LDA from 25.4% (MDA) to 43.9% (patient-perceived LDA). Thus, patient-perceived remission/LDA was frequent (65.4%). Agreement between patient-perceived remission/LDA and composite scores was moderate to good (kappa range, 0.12–0.65). When patient-perceived remission or LDA status is used as reference, DAPSA-defined remission/LDA and VLDA/MDA had a sensitivity of 73.1% and 51.5%, respectively, and a specificity of 76.8% and 88.0%, respectively. Physician-perceived remission/LDA using a single question was frequent (67.6%) but performed poorly against other definitions.ConclusionIn this unselected population, remission/LDA was frequently attained. VLDA/MDA was a more stringent definition than DAPSA-based remission/LDA. DAPSA-based remission/LDA performed better than VLDA/MDA to detect patient-defined remission or remission/LDA. Further studies of long-term outcomes are needed.
Published: 2019

45. Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA

Author: Jere Reijula, De Yun Wang, Ralph Mösges, Tomohisa Iinuma, Jean Luc Fauquert, Nelson Rosario, Yehia El-Gamal, René Maximiliano Gómez, Tari Haahtela, Vincenzo Patella, Lorenzo Cecchi, Petr Panzner, Yoshitaka Okamoto, Oliver Pfaar, Luis Caraballo, Paulo Augusto Moreira Camargos, Filip Raciborski, Florin Mihaltan, Ken Ohta, Brian J. Lipworth, Kimi Okubo, Juan Carlos Ivancevich, Fulvio Braido, Ioana Agache, Frederico S. Regateiro, Neven Miculinic, Tuula Vasankari, R. Emuzyte, Arunas Valiulis, Yousser Mohammad, Torsten Zuberbier, Osman M. Yusuf, Ewa Jassem, Cezmi A. Akdis, Jean Bousquet, Alessandro Fiocchi, Jan Hagemann, Claus Bachert, Davor Plavec, K. S. Bennoor, Marek Jutel, Désirée Larenas-Linnemann, Stephen Montefort, Stefano Del Giacco, Przemyslaw Kardas, Erkka Valovirta, Mark S. Dykewicz, Antonio Valero, Wienczyslawa Czarlewski, Thomas B. Casale, Gabrielle L. Onorato, Omer Kalayci, Ludger Klimek, Joaquin Sastre, João Fonseca, Siân Williams, Karl Christian Bergmann, Marek Niedoszytko, Bilun Gemicioglu, Mario E. Zernotti, Musa Khaitov, H. Neffen, Robert M. Naclerio, Joaquim Mullol, Ana Pereira, Piotr Kuna, Michael Makris, Maria Teresa Ventura, Ioanna Tsiligianni, Dirceu Solé, Arzu Yorgancioglu, Charlotte Suppli-Ulrik, M. Gotua, Emmanuel P. Prokopakis, Dana Wallace, Jorge Maspero, Wytske Fokkens, Eckard Hamelmann, Antonino Romano, Dejan Dokic, Todor A. Popov, Violeta Kvedariene, Derek K. Chu, Anna Bedbrook, Dermot Ryan, Motohiro Ebisawa, Tomas Chivato, Giovanni Passalacqua, Menachem Rottem, Mário Morais-Almeida, Victoria Cardona, Bolesław Samoliński, Cristiana Stellato, Nikolaos G. Papadopoulos, Milan Sova, Jaime Correia-de-Sousa, Sietze Reitsma, Cemal Cingi, Francesca Puggioni, Robyn E O'Hehir, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, HUS Internal Medicine and Rehabilitation, Department of Public Health, Clinicum, Keuhkosairauksien yksikkö, Helsinki University Hospital Area, University of Helsinki, University Medical Center of the Johannes Gutenberg-University Mainz, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Wrocław [Poland] (UWr), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Transilvania University of Brasov, Humboldt University Of Berlin, Medical Consulting Czarlewski, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), MASK-air, Ghent University Hospital, Sun Yat-Sen University [Guangzhou] (SYSU), Karolinska Institutet [Stockholm], National Institute of Diseases of the Chest and Hospital (NIDCH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Ospedale Policlinico San Martino [Genoa], Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), University of Cartagena, Foundation for the Development of Medical and Biological Sciences (FUNDEMEB), Vall d'Hebron University Hospital [Barcelona], Allergy Unit [Malaga, Spain] (National Network ARADyAL), Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain], University of South Florida [Tampa] (USF), Azienda Usl Toscana centro [Firenze], CEU-San Pablo University and HM-Hospitals School of Medicine, McMaster University [Hamilton, Ontario], Eskisehir Osmangazi University, Universidade do Minho = University of Minho [Braga], Life and Health Sciences Research Institute [Braga] (ICVS), University of Minho [Braga], The International Primary Care Respiratory Group (IPCRG), Università degli Studi di Cagliari = University of Cagliari (UniCa), Sts. Cyril and Methodius University, Saint Louis University School of Medicine [St Louis], Sagamihara National Hospital [Kanagawa, Japan], Ain Shams University (ASU), Vilnius University [Vilnius], Service de Pédiatrie Générale [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Bambino Gesù Children’s Hospital [Rome, Italy], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, CUF Porto Hospital, Cerrahpasa Faculty of Medicine, Istanbul University, ALAS Medical Institute, Center for Allergy and Immunology Research [Tbilisi], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Universität Bielefeld = Bielefeld University, Chiba University Hospital, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Medical University of Gdańsk, Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Medical University of Łódź (MUL), Federal Medicobiological Agency [Moscow, Russian Federation], Hospital Medica Sur [Mexico City, Mexico], Ninewells Hospital and Medical School [Dundee], University General Hospital ' Attikon ' [Athens, Greece], Argentine Association of Allergy and Immunology, Marius Nasta Institute of Pneumology, Tishreen University, Université de Damas = Damascus University, University of Malta [Malta], Hospital CUF Descobertas, Clinical Research International Ltd [Hamburg, Germany] (CRI), Johns Hopkins University School of Medicine [Baltimore], Nemours/Alfred I. du Pont Hospital for Children, Monash University [Melbourne], Tokyo National Hospital, Nippon Medical School [Tokyo, Japon], Medicine Charles University and General Faculty Hospital in Prague, Royal Manchester Children's Hospital, University of Manchester [Manchester], Università degli studi di Genova = University of Genoa (UniGe), 'Santa Maria della Speranza' Hospital, Philipps Universität Marburg = Philipps University of Marburg, J.J. Strossmayer University of Osijek, Children’s Hospital Srebrnjak [Zagreb, Croatia], St. Ivan Rilski University Hospital, University of Crete [Heraklion] (UOC), IRCCS Humanitas [Rozzano, Italy], Medical University of Warsaw - Poland, Centro Hospitalar e Universitário [Coimbra], Amsterdam UMC - Amsterdam University Medical Center, Istituto di Ricovero e Cura a Carattere Scientifico [Troina, Italy] (IRCCS), Oasi Maria Santissima Srl [Troina, Italy], Clinica G.B. Morgagni (Fondazione Mediterranea), Pontifical Catholic University of Paraná (PUCPR), Pontifícia Universidade Católica do Paraná (PUCPR), Ha’Emek Medical Center [Afula, Israel], Pediatric Endocrine Institute [Afula, Israel], Usher Institute of Population Health Sciences and Informatics [Edinburgh, U.K.], University of Edinburgh, Federal University of Sao Paulo (Unifesp), University Hospital Olomouc [Czech Republic], University of Salerno (UNISA), Copenhagen University Hospital, Universitat de Barcelona (UB), European Academy of Paediatrics (EAP/UEMS-SP), University of Turku, Suomen Terveystalo Allergy Clinic, Finnish Lung Health Association, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Nova Southeastern University (NSU), Yong Loo Lin School of Medicine [Singapore], Department of Biology, Faculty of Sciences & Liberal Arts, Celal Bayar University, Manisa Celal Bayar University, The Allergy & Asthma Institute, Pakistan (IPCRG), Universidad Nacional de Villa María, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Allergiezentrum Wiesbaden, Salvy-Córdoba, Nathalie, Ear, Nose and Throat, and AII - Inflammatory diseases
Subjects: 0301 basic medicine, Allergy, MESH: Asthma, Common Cold, allergic rhinitis, common cold, cough, COVID-19, smell, Consensus, Humans, SARS-CoV-2, Asthma, Rhinitis, Allergic, Disease, Care, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Immunology and Allergy, MESH: COVID-19, Rhinitis, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Common cold, 3. Good health, MESH: Rhinitis, Allergic, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Original Article, medicine.symptom, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Immunology, Signs and symptoms, Asymptomatic, 03 medical and health sciences, Allergic, COVID‐19, Internal medicine, medicine, MESH: SARS-CoV-2, MESH: Consensus, MESH: Humans, business.industry, Rhinitis, Sinusitis, and Upper Airway Disease, CARE, medicine.disease, 030104 developmental biology, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 3121 General medicine, internal medicine and other clinical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ORIGINAL ARTICLES, Airway, business, MESH: Common Cold
Abstract: Background Although there are many asymptomatic patients, one of the problems of COVID-19 is early recognition of the disease. COVID-19 symptoms are polymorphic and may include upper respiratory symptoms. However, COVID-19 symptoms may be mistaken with the common cold or allergic rhinitis. An ARIA-EAACI study group attempted to differentiate upper respiratory symptoms between the three diseases. Methods A modified Delphi process was used. The ARIA members who were seeing COVID-19 patients were asked to fill in a questionnaire on the upper airway symptoms of COVID-19, common cold and allergic rhinitis. Results Among the 192 ARIA members who were invited to respond to the questionnaire, 89 responded and 87 questionnaires were analysed. The consensus was then reported. A two-way ANOVA revealed significant differences in the symptom intensity between the three diseases (p < .001). Conclusions This modified Delphi approach enabled the differentiation of upper respiratory symptoms between COVID-19, the common cold and allergic rhinitis. An electronic algorithm will be devised using the questionnaire.
Published: 2021

46. The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders

Author: Pavel Rossner, Roger W. L. Godschalk, Lada Živković, Gunnar Brunborg, Mahara Valverde, Juliana da Silva, Emilio Rojas, E. S. Kuznetsova, Serena Galati, Palma Lamonaca, Mirta Milić, Ekaterina I. Surikova, Helga Stopper, Bozena Novotna, Ninoslav Djelic, Sabine A. S. Langie, Katarina Volkovova, Pierre Lebailly, Delia Cavallo, Karl-Heinz Wagner, Stefano Bonassi, Monica Neri, Malgorzata Dobrzyńska, Hervé Perdry, Carina Ladeira, Alena Kažimı́rová, Rudolf Stetina, Mojgan Najafzadeh, Diana Anderson, Amaya Azqueta, Semra Sardas, Zdenka Durackova, Paula Rohr, Cristiana Pereira, Bozena Smolkova, Annamaria Buschini, Andrew Collins, Dwi Ramadhani, Anna Safar, Goran Gajski, N. P. Sirota, Idoia Ibero-Baraibar, Avdulla J. Alija, Kirsten B. Holven, Ezgi Eyluel Bangkoglu, Marcello Ceppi, Cristian Del Boˊ, Francesca Marcon, Stine Marie Ulven, Elisa Boutet-Robinet, Inger Ottestad, Biljana Spremo-Potparević, Fisnik Asllani, Annemarie Grindel, Irina A. Goroshinskaya, Maria Dusinska, Zsuzsanna Nemeth, Ricard Marcos, Tania Mandina Cardoso, Lisa Giovannelli, Vanessa Moraes de Andrade, Cinzia Lucia Ursini, Maria João Silva, Massimo Moretti, Magdalena Barancokova, Nurşen Başaran, Monika Dvořáková, Solange Costa, Vesna Dimitrijević Srećković, Susana Pastor, Omar García Lima, Marta Staruchova, Vanessa Valdiglesias, Patrizia Riso, Carlos Hernández, Cristina Andreoli, Blanca Laffon, Alba Hernández, Kristine B. Gutzkow, Carla Costa, Marco Bruzzone, Zuzana Paduchova, Peter Møller, Ela Kadioglu, João Paulo Teixeira, Gudrun Koppen, Pavel Vodicka, Henriqueta Louro, Irene Orlow, Silvia Moretti, Institute for Medical Research and Occupational Health, Ospedale Policlinico San Martino [Genoa], Universidad de Navarra [Pamplona] (UNAV), Center for Applied Medical Research [Plamplona] (CIMA), Norwegian Institute of Public Health [Oslo] (NIPH), School of Nutrition and Translational Research in Metabolism [Maastricht] (NUTRIM), Maastricht University [Maastricht], Flemish Institute for Technological Research (VITO), University of Copenhagen = Københavns Universitet (KU), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), University of Prishtina, University of Bradford, University of Southern Santa Catarina [Florianopolis] (UNISUL), Istituto Superiore di Sanita [Rome], University of Würzburg, Slovak Medical University of Bratislava (SMU), Hacettepe University = Hacettepe Üniversitesi, Contaminants & Stress Cellulaire (ToxAlim-COMICS), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Chemistry, Life Sciences and Environmental Sustainability [Parma], University of Parma = Università degli studi di Parma [Parme, Italie], Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro [Italian Workers Compensation Authority] (INAIL), Universidade Luterana do Brasil - ULBRA (BRAZIL), Universidade Luterana do Brasil (ULBRA), Department of Food Environmental and Nutritional Sciences, (DeFENS), University of Milan, School of Medecine [Belgrade], University of Belgrade [Belgrade], Faculty of Veterinary Medicine [Belgrade, Serbie], National Institute of Public Health - National Institute of Hygiene [Poland], Comenius University in Bratislava, Centro de Protección e Higiene de las Radiaciones [Cuba] (CPHR), NEUROFARBA Department [Firenze, Italy], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Petrov Research Insitut of Oncology, University of Vienna [Vienna], Universitat Autònoma de Barcelona (UAB), Institute of Health Carlos III, Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Gazi University, Institute Of Theoretical And Experimental Biophysics, Escola Superior de Tecnologia da Saude de Lisboa, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University of A Coruña (UDC), Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Casa Sollievo della Sofferenza [San Giovanni Rotondo] (IRCCS), Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Dept. of Pharmaceutical Sciences, University of Perugia, National center for public health [Hungary], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Czech Academy of Sciences [Prague] (CAS), Memorial Sloane Kettering Cancer Center [New York], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Faculty of Pharmacy, National Nuclear Energy Agency of Indonesia (BATAN), Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México (UNAM), Istinye University, the Russian Academy of Sciences [Moscow, Russia] (RAS), Slovak Academy of Science [Bratislava] (SAS), Faculty of Military Technology [Brno] (FMT / UoD), University of Defence in Brno (UoD), Centro de Investigacións Científicas Avanzadas (CICA), Institute of Clinical and Experimental Medicine, Norsk Institutt for Luftforskning (NILU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, and Instituto de Saúde Pública da Universidade do Porto
Subjects: 0301 basic medicine, DNA damage, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Environmental Genotoxicity, Population, Biomarkers, Comet assay, Human biomonitoring, Pooled analysis, HOST FACTORS, Computational biology, Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, HUMAN MICRONUCLEUS PROJECT, 0302 clinical medicine, Biomonitoring, Genetics, Humans, education, education.field_of_study, Confounding, Random effects model, 3. Good health, HUMAN-LYMPHOCYTES, Genómica Funcional e Estrutural, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, CELLS, Biomarker (medicine), Genotoxicidade Ambiental, SMOKING, DNA
Abstract: [Abstract] The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take into account the extensive heterogeneity of data, due to descriptor, specimen and protocol variability. As a result of this analysis interquartile intervals of DNA strand breaks (which includes alkali-labile sites) were reported for tail intensity, tail length, and tail moment (comet assay descriptors). A small variation by age was reported in some datasets, suggesting higher DNA damage in oldest age-classes, while no effect could be shown for sex or smoking habit, although the lack of data on heavy smokers has still to be considered. Finally, highly significant differences in DNA damage were found for most exposures investigated in specific studies. In conclusion, these data, which confirm that DNA damage measured by the comet assay is an excellent biomarker of exposure in several conditions, may contribute to improving the quality of study design and to the standardization of results of the comet assay in human populations. This article is based upon work from COST Action hCOMET CA15132, supported by COST (European Cooperation in Science and Technology www.cost.eu) - STSM fellowships for Mirta Milić (IMROH, EU 19); IMROH, Zagreb, Croatia, Institute for Medical Research and Occupational Health (IMROH), Zagreb, Croatia, and the Ministry of Science, Education and Sports of the Republic of Croatia (Grant No. 022-0222148-2125) (EU4); Cancer Plan for PestiBG; Grant number: no ENV201401(EU 8, EU9); Italian Ministry of Education, University and Research PRIN 2005, prot. 2005058197 and Cariplo Foundation (Milan, Italy), Rif. Pratica 2007-5810 and Rif. Pratica 2010.2303 (EU 18); Associazione Italiana per la Ricerca sul Cancro (AIRC) (IG 2015/17564). (EU19); European Union Integrated Projects New Generis, 6th Framework Programme, Priority 5: Food Quality and Safety; Newborns and Genotoxic Exposure Risks, FOOD-CT-2005-016320 (EU22); ACT project No. 036APy/09 and No. 005DBB/12 (EU 24); FCT-SFRH/BPD/96196/2013, SFRH/BPD/100948/2014, Portugal (EU 26); MZ 2012/8-UKBA-8; VEGA 1/0703/13, APVV 15-0063 (EU30); Xunta de Galicia (XUGA 10605B98; INCITE08PXIB106155PR; ED481B2016/190-0; Grants ED431B2019/02), Spain (EU 32); Grant 01 173034, Ministry of Education, Science and Technological Development of the Republic of Serbia (EU 42); The Centre for Industrial and Technological Development within National Strategic Consortia for Techical Research (Industrial Research diets and food with specific characteristics for elderly, SENIFOOD); University of Navarra LE/97; Physiopathology of Obesity and Nutrition (CIBER Obn); Carlos III Health Research Institute (CB12/03/30002); Ministerio de Economia y Compatitividad (‘Ramón y Cajal’ Programme, RYC-2013-14370) of the Spanish Government for personal support (EU 45); the Ministry of Education, Youth and Sports of the Czech Republic project Healthy Aging in Industrial Environment HAIE (CZ.02.1.01/0.0/0.0/16_019/0000798) which is co-financed by the European Union (European Structural and Investment funds; Operation Programme Research, Development and Education); MYES LO 1508 (EU 46); MICRODIAB Study; ClinicalTrials.org (#NCT02231736) (EU 52); The study was funded by the Italian Ministry for Education, University and Scientific Research (MIUR) - Research No. 2005-062547 (EU14, EU53); Projects financed from Serbian Ministry of Education, Science and Technological Development #11146002, #175035, #173034 (EU 54); Mehr foundation organisation, UK (EU 55); MCTI/CNPQ No. 01/2016-Universal; FAPESC No. 09/2015; MEC/MCTI/CAPES/CNPQ/FAPS/ No. 09/2014, Brazil (CSA 6); the National Nuclear Energy Agency of Indonesia (Badan Tenaga Nuklir Nasional) with contract number 080.01.06 3447.001 001.052.A (AS4); Slovak Grant Agency (APVT-21 013202, APVT-21- 017704); Ministry of Health, Slovak Republic (2005/43-SZU-21, 2006/07- SZU-02 MZ SR, 2005/42-SZU-20
Published: 2021

47. Mycosands: Fungal diversity and abundance in beach sand and recreational waters & mdash; Relevance to human health

Author: Betil Özhak, R.O. Rusu, Nina Gunde-Cimerman, Anna Prigitano, Aleksandra Barac, M.A. Efstratiou, A.M. Tortorano, Michelle Bull, Aurora Gitto, Esther Segal, Belinda Chapman, João Brandão, Willem J. G. Melchers, Wim G. Meijer, Dilara Ogunc, Andra-Cristina Bostanaru, Mümtaz Güran, H. Guégan, Jean-Pierre Gangneux, Sevtap Arikan-Akdagli, Laszlo Irinyi, Marlou Tehupeiory-Kooreman, Lena Klingspor, Jayne H. Stephens, Ana Sampaio, Cristina Veríssimo, Nilgun Cerikcioglu, M. Novak Babič, M. Kataržytė, C.I. Gonçalves, Aristea Velegraki, G.C. Wunderlich, Stéphane Ranque, Raquel Sabino, E. Jonikaitė, Mihai Mares, Wieland Meyer, M. Frenkel, S. Brito, Susana Silva, J. Meletiadis, Valentin Nastasa, Çağrı Ergin, Universidade de Lisboa = University of Lisbon (ULISBOA), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hacettepe University = Hacettepe Üniversitesi, Clinical Centre of Serbia, University of the Aegean, Pamukkale University, Kfar Saba and Sackler School of Medicine, University College Dublin [Dublin] (UCD), University of Trás-os-Montes and Alto Douro [Portugal] (UTAD), Centre for Infectious Disease and Microbiology (CIDM), The Westmead Institute for Medical Research, The University of Sydney, Klaipėda University [Lituanie] (KU), Karolinska Institutet [Stockholm], Radboud University Medical Center [Nijmegen], Università degli Studi di Milano = University of Milan (UNIMI), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Universidade de Lisboa (ULISBOA), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Università degli Studi di Milano [Milano] (UNIMI), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)
Subjects: fungal detection, 010504 meteorology & atmospheric sciences, Beaches, yeast, 01 natural sciences, Recreational water, Fusarium, Genus, swimming, Fungal diversity, Waste Management and Disposal, Ecology, fungus, microbiological parameters, Pollution, 6. Clean water, Água e Solo, Fungi in sand, Geography, Aspergillus, priority journal, Black Sea, Italy, Water pollution, allergenicity, seashore, Environmental Engineering, Adriatic Sea, Urban growth, Article, Agentes Microbianos e Ambiente, Mediterranean Sea, Sydney [New South Wales], Humans, human, species diversity, Beach, bathing water, microbiology, Australia, Sediment, 15. Life on land, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], microbial diversity, Water quality, Bathing, Mycobiota, [SDV]Life Sciences [q-bio], Allergenic fungus, relative abundance, coastal waters, Fresh Water, health status, 010501 environmental sciences, geography, population abundance, environmental management, Human health, Fungal Diversity, Abundance (ecology), Sand, freshwater environment, Atlantic Ocean, Candida, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], biology, dermatophyte, Fungi in Sand, fungal membrane, New South Wales, Beach sand, Water Microbiology, Allergenic fungi, Colony forming units, Baltic Sea, Fungus in sand, Bathing Beaches, Mycosis, All institutes and research themes of the Radboud University Medical Center, parasitic diseases, Environmental Chemistry, 14. Life underwater, environmental protection, 0105 earth and related environmental sciences, Infecções Sistémicas e Zoonoses, nonhuman, Arthrodermataceae, Fungi, Filobasidiella, Bathing water, biology.organism_classification, sediment, 13. Climate action, colony forming unit, Mycota, fungal disease, urban area
Abstract: The goal of most studies published on sand contaminants is to gather and discuss knowledge to avoid faecal contamination of water by run-offs and tide retractions. Other life forms in the sand, however, are seldom studied but always pointed out as relevant. The Mycosands initiative was created to generate data on fungi in beach sands and waters, of both coastal and freshwater inland bathing sites. A team of medical mycologists and water quality specialists explored the sand culturable mycobiota of 91 bathing sites, and water of 67 of these, spanning fromthe Atlantic to the EasternMediterranean coasts, including the Italian lakes and the Adriatic, Baltic, and Black Seas. Sydney (Australia) was also included in the study. Thirteen countries took part in the initiative. The present study considered several fungal parameters (all fungi, several species of the genus Aspergillus and Candida and the genera themselves, plus other yeasts, allergenic fungi, dematiaceous fungi and dermatophytes). The study considered four variables that the team expected would influence the results of the analytical parameters, such as coast or inland location, urban and non-urban sites, period of the year, geographical proximity and type of sediment. The genera most frequently found were Aspergillus spp., Candida spp., Fusarium spp. and Cryptococcus spp. both in sand and in water. A site-blind median was found to be 89 Colony-Forming Units (CFU) of fungi per gram of sand in coastal and inland freshwaters, with variability between 0 and 6400 CFU/g. For freshwater sites, that number was 201.7 CFU/g (0, 6400 CFU/g (p = 0.01)) and for coastal sites was 76.7 CFU/g (0,3497.5 CFU/g). For coastalwaters and allwaters, themedianwas 0 CFU/ml (0, 1592 CFU/ml) and for freshwaters 6.7 (0, 310.0) CFU/ml (p < 0.001). The results advocate that beaches should bemonitored for fungi for safer use and better management. Highlights: Fungi are missing from water and sand health protection regulatory parameters; Both sand and water should be monitored for fungi; The median value of 89 CFU/g of all fungi may serve as a reference for sand regulation; Candida albicans, dermatophytes, endemic fungi and other fungi should be considered; Fungal analysis of water needs more data before reference values can be established. Acknowledgements: A. Abdillah, M. C. Esposto, J. Kabtani, K. Sarioglou, P. E. Verweij and F. Vieira for their collaboration in this study; the European Confederation of Medical Mycology for a seeding grant; the International Society for Human and Animal Mycology for some financial support; financial support from CESAM (UID/AMB/50017-POCI-01-0145-FEDER-007638) and CITAB (UID/AGR/04033/2019), via FCT/MCTES, from national funds (PIDDAC), cofounded by FEDER, (PT2020 Partnership Agreement and Compete 2020) and an NHMRC APP1121936 to W. Meyer; National and Kapodistrian University of Athens, Greece, Special Accounts for Research Grants (SARG K.A. 70/3/6915). info:eu-repo/semantics/publishedVersion
Published: 2021

48. DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

Author: Bonassi, Stefano, Ceppi, Marcello, Møller, Peter, Azqueta, Amaya, Milić, Mirta, Monica, Neri, Brunborg, Gunnar, Godschalk, Roger, Koppen, Gudrun, Langie, Sabine A. S., Teixeira, João Paulo, Bruzzone, Marco, Da Silva, Juliana, Benedetti, Danieli, Cavallo, Delia, Ursini, Cinzia Lucia, Giovannelli, Lisa, Moretti, Silvia, Riso, Patrizia, Del Bo’, Cristian, Russo, Patrizia, Dobrzyńska, Malgorzata, Goroshinskaya, Irina A., Surikova, Ekaterina I., Staruchova, Marta, Barančokova, Magdalena, Volkovova, Katarina, Kažimirova, Alena, Smolkova, Bozena, Laffon, Blanca, Valdiglesias, Vanessa, Pastor, Susana, Marcos, Ricard, Hernández, Alba, Gajski, Goran, Spremo-Potparević, Biljana, Živković, Lada, Boutet-Robinet, Elisa, Perdry, Hervé, Lebailly, Pierre, Perez, Carlos L., Basaran, Nursen, Nemeth, Zsuzsanna, Safar, Anna, Dusinska, Maria, Collins, Andrew, Anderson, Diana, Andrade, Vanessa, Pereira, Cristiana Costa, Costa, Solange, Gutzkow, Kristine B., Ladeira, Carina, Moretti, Massimo, Costa, Carla, Orlow, Irene, Rojas, Emilio, Pourrut, Bertrand, Kruszewski, Marcin, Knasmueller, Siegfried, Shaposhnikov, Sergey, Žegura, Bojana, Stopper, Helga, LESUR, Hélène, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Ospedale Policlinico San Martino [Genoa], University of Copenhagen = Københavns Universitet (UCPH), Universidad de Navarra [Pamplona] (UNAV), Instituto de Investigación Sanitaria de Navarra [Pamplona, Spain] (IdiSNA), Institute for Medical Research and Occupational Health, Norwegian Institute of Public Health [Oslo] (NIPH), School of Nutrition and Translational Research in Metabolism [Maastricht] (NUTRIM), Maastricht University [Maastricht], Flemish Institute for Technological Research (VITO), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Universidade Luterana do Brasil - ULBRA (BRAZIL), Universidade Luterana do Brasil (ULBRA), Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro [Italian Workers Compensation Authority] (INAIL), NEUROFARBA Department [Firenze, Italy], Università degli Studi di Firenze = University of Florence (UniFI), Université de Florence, Università degli Studi di Milano = University of Milan (UNIMI), IRCCS San Raffaele Scientific Institute [Milan, Italie], National Institute of Public Health - National Institute of Hygiene [Poland], N.N. Blokhin National Medical Research Center of Oncology, Slovak Medical University of Bratislava (SMU), Slovak Academy of Science [Bratislava] (SAS), University of A Coruña (UDC), Instituto de Investigación Biomédica de A Coruña [La Corogne, Espagne] (INIBIC), A Coruña University Hospital [La Corogne, Espagne], Universitat Autònoma de Barcelona (UAB), CIBER de Epidemiología y Salud Pública (CIBERESP), School of Medecine [Belgrade], University of Belgrade [Belgrade], Contaminants & Stress Cellulaire (ToxAlim-COMICS), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Hacettepe University = Hacettepe Üniversitesi, National center for public health [Hungary], Norwegian Institute for Air Research (NILU), University of Oslo (UiO), This article is based upon work from COST Action CA15132 (hCOMET), supported by COST (European Cooperation in Science and Technology). The work of SB and PR was supported by funds granted by the Italian Ministry of Health for Institutional Research (Ricerca Corrente)., Farmacologie en Toxicologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, University of Copenhagen = Københavns Universitet (KU), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Università degli Studi di Milano [Milano] (UNIMI), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, and Instituto de Saúde Pública da Universidade do Porto
Subjects: Oncology, [SDV]Life Sciences [q-bio], Chromosomal aberrations, Human cancer, Lymphocytes, Predicts, Frequency, Validation, Biomarkers, Hallmarks, Adducts, Repair, Cohort, Kaplan-Meier Estimate, 0302 clinical medicine, Neoplasms, Leukocytes, Medicine, Gel electrophoresis, 0303 health sciences, Multidisciplinary, Hazard ratio, 3. Good health, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, Biomarker (medicine), LYMPHOCYTES PREDICTS, Comet Assay, Cell-Free Nucleic Acids, medicine.medical_specialty, DNA damage, Science, FREQUENCY, Article, VALIDATION, 03 medical and health sciences, ADDUCTS, Internal medicine, Humans, COHORT, Risk factor, Author Correction, 030304 developmental biology, Proportional Hazards Models, HALLMARKS, REPAIR, HUMAN CANCER, business.industry, Proportional hazards model, Comet assay, biomarker, leukocytes, epidemiology, Comet assay, CHROMOSOMAL-ABERRATIONS, Risk factors, Genotoxicidade Ambiental, business, DNA Damage
Abstract: Author Correction: https://doi.org/10.1038/s41598-021-98620-6. The original version of this Article contained errors: The spelling of the author Monica Neri was incorrectly given as Neri Monica; Additionally, Affiliation 39 was incorrectly given as ‘National Institute of Health, Lisbon, Portugal’, the correct affiliation is listed below: National Institute of Health Doutor Ricardo Jorge, Porto, Portugal. The original Article has been corrected. [Abstract] The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p
Published: 2021

49. Determinants of Patient-Reported Psoriatic Arthritis Impact of Disease:An Analysis of the Association With Sex in 458 Patients From Fourteen Countries

Author: Uta Kiltz, Andra Balanescu, Ying Ying Leung, Lihi Eder, Sibel Zehra Aydin, Sandra Tälli, Penelope Esther Palominos, Rossana Scrivo, Clémence Gorlier, Ennio Lubrano, Juan D. Cañete, Maarten de Wit, Ana Maria Orbai, Inna Gaydukova, M. Elaine Husni, Adeline Ruyssen-Witrand, Pascal Richette, Laura C. Coates, Josef S Smolen, Laure Gossec, Emmanuelle Dernis, Martin Soubrier, Umut Kalyoncu, Jamie Perin, Gestionnaire, Hal Sorbonne Université, Johns Hopkins University (JHU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Oxford, Ruhr University Bochum (RUB), Singapore General Hospital, Hospital de Clínicas de Porto Alegre (HCPA), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université de Médecine Carol Davila, Centre Hospitalier Le Mans (CH Le Mans), East Tallinn Central Hospital, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Ottawa Hospital Research Institute [Ottawa] (OHRI), University of Toronto, North-Western State Medical University [St Petersburg, Russia], Università degli Studi del Molise = University of Molise (UNIMOL), Hacettepe University = Hacettepe Üniversitesi, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques (BIOSCAR (UMR_S_1132 / U1132)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Cleveland Clinic, Medizinische Universität Wien = Medical University of Vienna, Amsterdam UMC - Amsterdam University Medical Center, Service de Rhumatologie [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Ethics, Law & Medical humanities
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], Disease, patient reported outcomes, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Treatment targets, Rheumatology, Rating scale, life impact, Internal medicine, gender, medicine, sex, treatment target, psoriatic arthritis, 030203 arthritis & rheumatology, Adult patients, business.industry, Enthesitis, Odds ratio, medicine.disease, [SDV] Life Sciences [q-bio], medicine.symptom, Antirheumatic drugs, business
Abstract: International audience; Objective: Sex differences may modify symptoms, disease expression, and treatment effects. The objective of this study was to evaluate the link between life impact and sex in psoriatic arthritis (PsA).Methods: Remission and Flare in Psoriatic Arthritis (ReFlaP; ClinicalTrials.gov identifier: NCT03119805) was a study in 14 countries of consecutive adult patients with definite PsA. Participants underwent comprehensive PsA assessment using the following measures: Disease Activity in Psoriatic Arthritis (DAPSA), Minimal Disease Activity (MDA), and Psoriatic Arthritis Impact of Disease (PsAID). Disease activity was compared by sex using t-tests or Wilcoxon tests. The association of PsAID with sex was analyzed using hierarchical generalized linear models.Results: Of 458 participants, 50.2% were male and the mean ± SD age was 53.1 ± 12.6 years. The mean ± SD PsA duration was 11 ± 8.2 years, and 51.5% of participants were being treated with biologic disease-modifying antirheumatic drugs. Women, compared to men, had worse mean ± SD Leeds Enthesitis Index scores (0.8 ± 1.7 versus 0.3 ± 0.9), pain on a numerical rating scale (NRS; range 0-10) (4.7 ± 2.7 versus 3.5 ± 2.7), HAQ DI scores (0.9 ± 0.7 versus 0.5 ± 0.6), fatigue on an NRS (5.2 ± 3 versus 3.3 ± 2.8), and PsAID scores (4.1 ± 2.4 versus 2.8 ± 2.3) (P < 0.001 for all). Women were also less frequently at treatment target compared to men according to DAPSA (cutoffs of ≤4 for remission and >4 and ≤14 for low disease activity; mean ± SD score 16.9 ± 14.9 in women versus 12.6 ± 16.6 in men) and MDA (25.7% versus 50.0%; P < 0.001 for all) scores. High life impact (PsAID score ≥4) was associated with female sex (odds ratio [OR] 2.3), enthesitis (OR 1.34), tender joints (OR 1.10)(P < 0.001 for all), and comorbidities (OR 1.22, P = 0.002).Conclusion: High life impact was independently associated with female sex, enthesitis, comorbidities, and tender joints. At treatment target, women had higher life impact compared to men. It is necessary for life impact to become a part of PsA treat-to-target strategies.
Published: 2020

50. Altitude and hillside orientation shapes the population structure of the Leishmania infantum vector Phlebotomus ariasi

Author: Rémi N. Charrel, Anne-Laure Bañuls, Bulent Alten, Céline Toty, Jorian Prudhomme, Denis Sereno, Cécile Cassan, Nil Rahola, Thierry De Meeûs, Baptiste Vergnes, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Virostyle (MIVEGEC-Virostyle), Perturbations, Evolution, Virulence (PEV), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Diversity, ecology, evolution & Adaptation of arthropod vectors (MIVEGEC-DEEVA), Evolution des Systèmes Vectoriels (ESV), Du gène à l'écosystème (MIVEGEC-GeneSys), Pathogènes, Environnement, Santé Humaine (EPATH), Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bordeaux (UB), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), cassan, cécile, and Génétique et évolution des maladies infectieuses (GEMI)
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], Population, Zoology, lcsh:Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Altitude, parasitic diseases, Animals, Humans, Genetic variation, Leishmania infantum, education, lcsh:Science, ComputingMilieux_MISCELLANEOUS, education.field_of_study, Multidisciplinary, Ecology, biology, Ecotype, Assortative mating, lcsh:R, Ecological genetics, biology.organism_classification, Insect Vectors, [SDV] Life Sciences [q-bio], Genetics, Population, 030104 developmental biology, Phlebotomus, Vector (epidemiology), Genetic structure, Leishmaniasis, Visceral, Microsatellite, lcsh:Q, France, Entomology, 030217 neurology & neurosurgery, Microsatellite Repeats
Abstract: Despite their role in Leishmania transmission, little is known about the organization of sand fly populations in their environment. Here, we used 11 previously described microsatellite markers to investigate the population genetic structure of Phlebotomus ariasi, the main vector of Leishmania infantum in the region of Montpellier (South of France). From May to October 2011, we captured 1,253 Ph. ariasi specimens using sticky traps in 17 sites in the North of Montpellier along a 14-km transect, and recorded the relevant environmental data (e.g., altitude and hillside). Among the selected microsatellite markers, we removed five loci because of stutter artifacts, absence of polymorphism, or non-neutral evolution. Multiple regression analyses showed the influence of altitude and hillside (51% and 15%, respectively), and the absence of influence of geographic distance on the genetic data. The observed significant isolation by elevation suggested a population structure of Ph. ariasi organized in altitudinal ecotypes with substantial rates of migration and positive assortative mating. This organization has implications on sand fly ecology and pathogen transmission. Indeed, this structure might favor the global temporal and spatial stability of sand fly populations and the spread and increase of L. infantum cases in France. Our results highlight the necessity to consider sand fly populations at small scales to study their ecology and their impact on pathogens they transmit.
Published: 2020

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