1. Change of pulmonary function tests in hospitalized COVID-19 patients at third and sixth month follow-up.
- Author
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Kafkas, Meltem Karakulak, Tüzün, Sabah, Hacıağaoğlu, Nazlı, Çetin, Hüseyin, Cömert, Sevda Şener, and Şimşek, Engin Ersin
- Subjects
PULMONARY function tests ,COVID-19 ,DIAGNOSTIC use of polymerase chain reaction ,COVID-19 testing ,LUNG infections - Abstract
Background The effect of COVID-19 infection on pulmonary function is unknown. Objective This study aimed to evaluate pulmonary function tests (PFTs) of patients hospitalized with the diagnosis of COVID-19 pneumonia at 3 and 6 months post-discharge. Methods Patients aged 18 years and over who had positive COVID-19 PCR test results and were hospitalized in the pandemic service between 1 May 2020 and 31 October 2020, were included in the study. All patients were evaluated with PFTs FVC, FEV1, FEV1/FVC, and FEF25–75 at 3 and 6 months after discharge. Results The mean age of 34 patients included in the study was 47.7 ± 12.7 years. The FVC, FEV1, FEV1/FVC, and FEF25–75 measurements at 3 and 6 months post-discharge showed no significant difference (P = 0.765, P = 0.907, P = 0.707, and P = 0.674, respectively). There was no significant difference in any PFT measurements at the third month follow-up, regardless of the pharmacological treatment protocols applied during hospitalization (P > 0.05). However, FEV1/FVC and FEF25–75 levels were 83.1 [3.4]% and 91.0 [10.0]%, respectively, in those who received systemic steroid treatment, and 78.3 ± 8.5% and 72.5 ± 25.7% in those who did not (P = 0.019 and P = 0.048, respectively). In addition, FVC and FEV1 levels increased significantly from the third to the sixth month follow-up in patients who received systemic steroid therapy (P = 0.035 and P = 0.018, respectively). Conclusion Although there is no significant difference in PFT measurements from 3 to 6 months in COVID-19 patients, systemic steroid therapy may have a beneficial effect on respiratory function in COVID-19 patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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