387 results on '"Haberlen, Sabina A"'
Search Results
2. Loneliness and Frailty Among Middle-Aged and Aging Sexual Minority Men Living With or Without HIV: A Longitudinal Cross-Lagged Panel Analysis
- Author
-
Meireles, Paula, Ware, Deanna, Henriques, Ana, Nieves-Lugo, Karen, Stosor, Valentina, Brennan-Ing, Mark, Meanley, Steven, Haberlen, Sabina, Okafor, Chukwuemeka N, Shoptaw, Steve, Friedman, M Reuel, and Plankey, Michael
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,HIV/AIDS ,Aging ,Prevention ,Clinical Research ,Aetiology ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,2.3 Psychological ,social and economic factors ,Infection ,Good Health and Well Being ,Frailty ,Multicenter AIDS cohort study ,Loneliness ,Sexual minority men ,United States ,Clinical sciences - Abstract
Background and objectivesLoneliness is associated with frailty among older adults (60+), and there is evidence suggesting that this association may be bidirectional. However, there is limited evidence of this relationship over time among middle-aged and aging sexual minority men. We explored the bidirectional relationship between loneliness and frailty over 2 years among sexual minority men living with or without human immunodeficiency virus (HIV) from the Healthy Aging substudy of the Multicenter AIDS Cohort Study.Research design and methodsWe used data from 1 118 men (561 living with HIV; 557 living without HIV) aged 40 years or older with measurement of frailty or loneliness at Times 1 (September 2016 to March 2017) and 2 (September 2018 to March 2019). Descriptive statistics were generated. We used autoregressive cross-lagged panel analysis to examine the bidirectional association between frailty and loneliness at both time points while adjusting for time-stable and time-dependent covariates at Time 1. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were generated.ResultsThe estimated prevalence of loneliness at both time points was 35.5%. The estimated prevalence of frailty at Times 1 and 2 were 7.8% and 12.1%, respectively. Participants reporting loneliness at Time 1 had greater odds of being frail at Time 2 (aOR = 2.14; 95% CI: 1.23-3.73). Frailty at Time 1 was not associated with loneliness at Time 2 (aOR = 1.00; 95% CI: .44-2.25). The autoregressive effects of frailty (aOR = 23.43; 95% CI: 11.94-46) and loneliness (aOR = 13.94; 95% CI: 9.42-20.61) were large.Discussion and implicationsMen who felt lonely had higher odds of being frail 2 years later while the reciprocal association was not shown. This suggests that loneliness preceded frailty and not the other way around. Early and frequent assessments of loneliness may present opportunities for interventions that minimize the risk of frailty among sexual minority men living with and without HIV.
- Published
- 2023
3. Syndemic trajectories of heavy drinking, smoking, and depressive symptoms are associated with mortality in women living with HIV in the United States from 1994 to 2017
- Author
-
Chichetto, Natalie E, Gebru, Nioud M, Plankey, Michael W, Tindle, Hilary A, Koethe, John R, Hanna, David B, Shoptaw, Steven, Jones, Deborah L, Lazar, Jason M, Kizer, Jorge R, Cohen, Mardge H, Haberlen, Sabina A, Adimora, Adaora A, Lahiri, Cecile D, Wise, Jenni M, and Freiberg, Matthew S
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Sexually Transmitted Infections ,Behavioral and Social Science ,Health Disparities ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Minority Health ,Women's Health ,Prevention ,Brain Disorders ,Mental Health ,HIV/AIDS ,Infectious Diseases ,Mental Illness ,Depression ,Good Health and Well Being ,Female ,United States ,Humans ,HIV Infections ,Syndemic ,Smoking ,Tobacco Smoking ,Women ,HIV ,Alcohol ,mortality ,Depression ,mortality ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Substance Abuse ,Biochemistry and cell biology ,Pharmacology and pharmaceutical sciences - Abstract
BackgroundHeavy drinking, smoking, and depression are common among people with HIV. Little is known about the co-occurring, synergistic effect of having two or more of these conditions long-term -a sustained syndemic - on mortality among women with HIV (WWH).MethodsData from 3282 WWH of the Women's Interagency HIV Study from 1994 to 2017 were utilized. National Death Index review identified cause of death (n=616). Sustained syndemic phenotypes were based on membership in high-risk groups defined by group-based trajectory models of repeated self-reported alcohol use, smoking, and depressive symptoms and their co-occurrence. Cox proportional hazard models estimated associations of sustained syndemic phenotypes with all-cause, non-AIDS, and non-overdose mortality, adjusting for age, race/ethnicity, education, enrollment wave, illicit drug use, and time-varying HIV viral load and CD4+ T-cell count.ResultsWWH were 58% Black and 26% Hispanic, with a mean baseline age of 36.7 years. Syndemic phenotypes included zero (45%, n=1463), heavy drinking only (1%, n=35), smoking only (28%, n=928), depressive symptoms only (9%, n=282), and 2+ trajectories (17%, n=574). Compared to zero trajectories, having 2+ trajectories was associated with 3.93 times greater all-cause mortality risk (95% CI 3.07, 5.04) after controlling for confounders and each high-risk trajectory alone. These findings persisted in sensitivity analyses, removing AIDS- and overdose-related mortalities.ConclusionsClustering of 2+ conditions of heavy drinking, smoking, and depression affected nearly one in five WWH and was associated with higher mortality than zero or one condition. Our findings underscore the need for coordinated screening and parsimonious treatment strategies for these co-occurring conditions.
- Published
- 2023
4. Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection
- Author
-
Giron, Leila B., Liu, Qin, Adeniji, Opeyemi S., Yin, Xiangfan, Kannan, Toshitha, Ding, Jianyi, Lu, David Y., Langan, Susan, Zhang, Jinbing, Azevedo, Joao L. L. C., Li, Shuk Hang, Shalygin, Sergei, Azadi, Parastoo, Hanna, David B., Ofotokun, Igho, Lazar, Jason, Fischl, Margaret A., Haberlen, Sabina, Macatangay, Bernard, Adimora, Adaora A., Jamieson, Beth D., Rinaldo, Charles, Merenstein, Daniel, Roan, Nadia R., Kutsch, Olaf, Gange, Stephen, Wolinsky, Steven M., Witt, Mallory D., Post, Wendy S., Kossenkov, Andrew, Landay, Alan L., Frank, Ian, Tien, Phyllis C., Gross, Robert, Brown, Todd T., and Abdel-Mohsen, Mohamed
- Published
- 2024
- Full Text
- View/download PDF
5. The role of social support on cognitive function among midlife and older adult MSM
- Author
-
Henderson, Emmett R, Haberlen, Sabina A, Coulter, Robert WS, Weinstein, Andrea M, Meanley, Steven, Brennan-Ing, Mark, Mimiaga, Matthew J, Turan, Janet M, Turan, Bulent, Teplin, Linda A, Egan, James E, Plankey, Michael W, and Friedman, M Reuel
- Subjects
Public Health ,Health Sciences ,Clinical Research ,Aging ,Behavioral and Social Science ,Mental Health ,Aetiology ,2.3 Psychological ,social and economic factors ,Male ,Humans ,Aged ,Cohort Studies ,Homosexuality ,Male ,Cross-Sectional Studies ,HIV Infections ,Sexual and Gender Minorities ,Cognition ,Social Support ,cognitive decline ,HIV ,AIDS ,MSM ,psychosocial health conditions ,social support ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveThis study examines the association between social support and cognitive function among midlife and older MSM living with or without HIV.DesignWe analyzed longitudinal data from participants enrolled from October 2016 to March 2019 in the Patterns of Healthy Aging Study, a substudy of the Multicenter AIDS Cohort Study.MethodsWe conducted a cross-sectional analysis to estimate the association between social support and three measures of cognitive function [Trail Making Test (TMT) Part A, TMT Part B to A ratio, and Symbol Digit Modalities Tasks (SDMT)]. We also used linear mixed-effects models to estimate the association between baseline social support and cognitive function across four subsequent time points. We evaluated a multiplicative interaction term between baseline social support and time, in order to determine whether cognitive trajectories over time vary by baseline social support.ResultsSocial support was associated with lower TMT Part A scores at baseline and over the subsequent 2 years, indicating better psychomotor ability. Social support was associated with higher SDMT scores at baseline and across 2 years, indicating better information processing. We observed no association between social support and TMT B to A ratio at baseline or across 2 years, indicating no effect on set-shifting ability. Longitudinal cognition outcome trajectories did not vary by the level of baseline social support.ConclusionSocial support and cognitive function were associated in this sample over a short time period. Further research should explore causal relationships over the lifespan.
- Published
- 2023
6. Grit is associated with psychological health among older sexual minority men
- Author
-
Okafor, Chukwuemeka N, Brennan-Ing, Mark, Ware, Deanna, Haberlen, Sabina, Egan, James E, Brown, Andre L, Meanley, Steven, Stosor, Valentina, Shoptaw, Steven, Friedman, M Reuel, and Plankey, Michael
- Subjects
Clinical and Health Psychology ,Health Sciences ,Psychology ,Depression ,Mental Health ,Aging ,Behavioral and Social Science ,Mental health ,Good Health and Well Being ,Male ,Humans ,Reproducibility of Results ,Cohort Studies ,Longitudinal Studies ,Anxiety ,Sexual and Gender Minorities ,Consistency of interests ,perseverance ,gay men ,aging ,HIV ,mental health ,Medical and Health Sciences ,Studies in Human Society ,Psychology and Cognitive Sciences ,Geriatrics ,Health sciences ,Human society - Abstract
Objectives: Studies have shown that grit-defined as perseverance and passion for achieving one's long-term goals-is associated with improved health outcomes, including lower levels of psychological distress. However, the psychometric properties of the original Grit Scale (Grit-O Scale) has not been validated among sexual minority men (SMM). The present study aimed to validate the Grit-O Scale among a sample of older SMM and assess the relationships between the Grit-O Scale factors and symptoms of psychological distress.Method: We used data from a single visit of participants in the Multicenter AIDS Cohort Study (MACS) Healthy Aging longitudinal study. The sample included 981 older SMM (mean age = 61, SD = 8.5) with and without HIV. We conducted confirmatory factor analysis (CFA) to identify the two factors of the Grit-O Scale: consistency of interest and perseverance of effort. We also conducted a latent profile analysis (LPA) to identify distinct profiles of psychological distress from self-reported scales of depression, anxiety, and perceived stress.Results:The Grit-O Scale showed acceptable reliability estimates for the items with Cronbach's alpha reliability coefficients ranging from 0.77 to 0.82. The CFA identified the two factors of the Grit-O Scale with acceptable model fit (root mean square error of approximation = 0.058 [95% CI = 0.050, 0.067], comparative fit index = 0.95, Tucker-Lewis Index = 0.93, standardized root mean square residual = 0.07). The LPA yielded three mutually exclusive profiles of psychological distress (profile 1: low stress, anxiety, and depression; profile 2: high stress and depression and low anxiety; and profile 3: high stress, anxiety, and depression). In adjusted multinominal logistic regression analysis, we found that both higher levels of consistency of interest and perseverance of effort factors of the Grit-O Scale were significantly associated with decreased odds of being in profiles 2 and 3 compared with being in profile 1.Conclusion: Our findings support the use of the Grit-O Scale among older SMM. Grit factors could explain variability in the negative psychological symptoms among older SMM and warrant further investigation.Supplemental data for this article is available online at http://dx.doi.org/10.1080/13607863.2022.2032594.
- Published
- 2023
7. Psychosocial Syndemic Classes and Longitudinal Transition Patterns Among Sexual Minority men Living with or Without HIV in the Multicenter AIDS Cohort Study (MACS)
- Author
-
Liu, Yiyang, Ramos, Stephen D, Hanna, David B, Jones, Deborah L, Lazar, Jason M, Kizer, Jorge R, Cohen, Mardge H, Haberlen, Sabina A, Adimora, Adaora A, Lahiri, Cecile D, Wise, Jenni M, Friedman, Mackey R, Plankey, Michael, and Chichetto, Natalie E
- Published
- 2023
- Full Text
- View/download PDF
8. Individual-Level Psychosocial Resiliencies as Mediators of the Relationship Between Internalized Homophobia and Depressive Symptoms Among Middle-Aged and Older Men Living With and Without HIV
- Author
-
Okafor, Chukwuemeka N., Ware, Deanna, Meanley, Steven, Brennan-Ing, Mark, Haberlen, Sabina, Teplin, Linda, Mimiaga, Matthew J., Reuel Friedman, M., and Plankey, Michael
- Published
- 2023
- Full Text
- View/download PDF
9. Clonal hematopoiesis in men living with HIV and association with subclinical atherosclerosis
- Author
-
Wang, Shiyu, Pasca, Sergiu, Post, Wendy S, Langan, Susan, Pallavajjala, Aparna, Haley, Lisa, Gocke, Christopher D, Budoff, Matthew, Haberlen, Sabina, Brown, Todd T, Ambinder, Richard F, Margolick, Joseph B, and Gondek, Lukasz P
- Subjects
Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Aging ,Clinical Research ,Heart Disease ,HIV/AIDS ,Prevention ,Cardiovascular ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Acquired Immunodeficiency Syndrome ,Biomarkers ,Cohort Studies ,Coronary Stenosis ,Cross-Sectional Studies ,HIV Infections ,Humans ,Leukocytes ,Mononuclear ,Male ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology - Abstract
ObjectivesPeople with HIV (PWH) are at increased risk for premature cardiovascular disease (CVD). Clonal hematopoiesis is a common age-related condition that may be associated with increased CVD risk. The goal of this study was to determine the prevalence of clonal hematopoiesis and its association with chronic inflammation and CVD in PWH.DesignCross-sectional study utilizing archived specimens and data from 118 men (86 PWH and 32 HIV-uninfected) from the Baltimore-Washington DC center of the Multicenter AIDS Cohort Study (MACS) who had had coronary computed tomography angiography (CTA) and measurement of 34 serologic inflammatory biomarkers.MethodsClonal hematopoiesis was assessed on peripheral blood mononuclear cells utilizing targeted error-corrected next generation sequencing (NGS) focused on 92 genes frequently mutated in hematologic malignancies. Clinical and laboratory data were obtained from the MACS database.ResultsClonal hematopoiesis with a variant allele frequency (VAF) greater than 1% was significantly more common in PWH [20/86 (23.3%)] than in HIV-uninfected men [2/32 (6.3%)] ( P = 0.035). PWH with clonal hematopoiesis (VAF > 1%) were more likely to have coronary artery stenosis of at least 50% than those without clonal hematopoiesis [6/20 (30%) vs. 6/64 (9%); P = 0.021]. Presence of clonal hematopoiesis was not significantly associated with serological inflammatory markers, except for significantly lower serum leptin levels; this was not significant after adjustment for abdominal or thigh subcutaneous fat area.ConclusionClonal hematopoiesis was more common in PWH and among PWH was associated with the extent of coronary artery disease. Larger studies are needed to further examine the biological and clinical consequences of clonal hematopoiesis in PWH.
- Published
- 2022
10. Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm
- Author
-
Jones, Deborah L, Zhang, Yuehan, Rodriguez, Violeta J, Haberlen, Sabina, Ramirez, Catalina, Adimora, Adaora A, Merenstein, Daniel, Aouizerat, Bradley, Sharma, Anjali, Wilson, Tracey, Mimiaga, Matthew J, Sheth, Anandi N, Plankey, Michael, Cohen, Mardge H, Stosor, Valentina, Kempf, Mirjam-Colette, and Friedman, M Reuel
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Behavioral and Social Science ,Cancer ,Clinical Research ,Prevention ,HIV/AIDS ,Post-Traumatic Stress Disorder (PTSD) ,Mental Health ,Infectious Diseases ,Aetiology ,2.4 Surveillance and distribution ,Good Health and Well Being ,Aged ,COVID-19 ,Cohort Studies ,Female ,HIV Infections ,Humans ,Male ,Middle Aged ,Pandemics ,Stress Disorders ,Post-Traumatic ,United States ,posttraumatic stress disorder ,HIV ,MACS ,WIHS ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
ObjectivesThis study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.MethodsData consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.ResultsStudy participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.ConclusionsThis study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.
- Published
- 2022
11. Gut Microbiota, Plasma Metabolomic Profiles, and Carotid Artery Atherosclerosis in HIV Infection
- Author
-
Wang, Zheng, Peters, Brandilyn A, Usyk, Mykhaylo, Xing, Jiaqian, Hanna, David B, Wang, Tao, Post, Wendy S, Landay, Alan L, Hodis, Howard N, Weber, Kathleen, French, Audrey, Golub, Elizabeth T, Lazar, Jason, Gustafson, Deborah, Kassaye, Seble, Aouizerat, Bradley, Haberlen, Sabina, Malvestutto, Carlos, Budoff, Matthew, Wolinsky, Steven M, Sharma, Anjali, Anastos, Kathryn, Clish, Clary B, Kaplan, Robert C, Burk, Robert D, and Qi, Qibin
- Subjects
Medical Biochemistry and Metabolomics ,Biomedical and Clinical Sciences ,Atherosclerosis ,HIV/AIDS ,Infectious Diseases ,Cardiovascular ,Clinical Research ,Prevention ,Aetiology ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Carotid Arteries ,Carotid Artery Diseases ,Carotid Stenosis ,Cross-Sectional Studies ,Female ,Gastrointestinal Microbiome ,HIV Infections ,Humans ,Lysophosphatidylcholines ,Male ,Plaque ,Atherosclerotic ,atherosclerosis ,cardiovascular diseases ,diglycerides ,lipid metabolism ,lipidomics ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundAlterations in gut microbiota and blood metabolomic profiles have been implicated in HIV infection and cardiovascular disease. However, it remains unclear whether alterations in gut microbiota may contribute to disrupted host blood metabolomic profiles in relation to atherosclerosis, especially in the context of HIV infection.MethodsWe analyzed cross-sectional associations between gut microbiota features and carotid artery plaque in 361 women with or at high risk of HIV (67% HIV+), and further integrated plaque-associated microbial features with plasma lipidomic/metabolomic profiles. Furthermore, in 737 women and men, we examined prospective associations of baseline gut bacteria-associated lipidomic and metabolomic profiles with incident carotid artery plaque over 7-year follow-up.ResultsWe found 2 potentially pathogenic bacteria, Fusobacterium and Proteus, were associated with carotid artery plaque; while the beneficial butyrate producer Odoribacter was inversely associated with plaque. Fusobacterium and Proteus were associated with multiple lipids/metabolites which were clustered into 8 modules in network. A module comprised of 9 lysophosphatidylcholines and lysophosphatidylethanolamines and a module comprised of 9 diglycerides were associated with increased risk of carotid artery plaque (risk ratio [95% CI], 1.34 [1.09-1.64] and 1.24 [1.02-1.51] per SD increment, respectively). Functional analyses identified bacterial enzymes in lipid metabolism associated with these plasma lipids. In particular, phospholipase A1 and A2 are the key enzymes in the reactions producing lysophosphatidylcholines and lysophosphatidylethanolamines.ConclusionsAmong individuals with or at high risk of HIV infection, we identified altered gut microbiota and related functional capacities in the lipid metabolism associated with disrupted plasma lipidomic profiles and carotid artery atherosclerosis.
- Published
- 2022
12. Suboptimal HIV suppression is associated with progression of coronary artery stenosis: The Multicenter AIDS Cohort Study (MACS) longitudinal coronary CT angiography study
- Author
-
Post, Wendy S, Haberlen, Sabina A, Witt, Mallory D, Zhang, Long, Jacobson, Lisa P, Brown, Todd T, Margolick, Joseph B, Kingsley, Lawrence, Palella, Frank J, and Budoff, Matthew
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,HIV/AIDS ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Infectious Diseases ,Infection ,Good Health and Well Being ,Cohort Studies ,Computed Tomography Angiography ,Constriction ,Pathologic ,Coronary Angiography ,Coronary Artery Disease ,Coronary Stenosis ,HIV Infections ,Humans ,Male ,Middle Aged ,Viremia ,Atherosclerosis ,HIV ,Coronary artery disease ,Coronary CT angiography ,Epidemiology ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Background and aimsPeople living with HIV (HIV+) are surviving longer due to effective antiretroviral therapy. Cardiovascular disease is a leading cause of non-AIDS related clinical events. We determined HIV-related factors associated with coronary artery stenosis progression.MethodsWe performed serial coronary CT angiography among HIV+ and HIV-uninfected (HIV-) men in the Multicenter AIDS Cohort Study. The median inter-scan interval was 4.5 years. Stenosis was graded as 0, 1-29, 30-49, 50-69 or ≥70%. Progression was defined as an increase ≥2 categories. Suppressed HIV infection was consistent viral loads 1 viral load >500 copies/ml demonstrated greatest stenosis progression (RR 3.01; 95% CI, 1.53-4.92, p = 0.001 compared with HIV- men). Suppressed HIV+ men with suboptimal antiretroviral adherence had greater stenosis progression (RR 1.91; 95% CI 1.12-3.24, p = 0.02) than HIV + suppressed men with optimal adherence.ConclusionsCoronary artery stenosis progression was associated with suboptimal HIV RNA suppression and antiretroviral therapy adherence. Effective ongoing HIV virologic suppression and antiretroviral therapy adherence may mitigate risk for coronary disease events among people living with HIV.
- Published
- 2022
13. Association of HIV Serostatus and Inflammation With Ascending Aortic Size
- Author
-
Minhas, Anum S, Post, Wendy S, Liu, Bin, De Vasconcellos, Henrique Doria, Haberlen, Sabina A, Feinstein, Matthew, Stosor, Valentina, Budoff, Matthew, Chew, Kara W, Magnani, Jared W, Brown, Todd, Lima, Joao AC, and Wu, Katherine C
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,HIV/AIDS ,Cardiovascular ,Clinical Research ,Infectious Diseases ,Aorta ,Cohort Studies ,HIV Infections ,Humans ,Inflammation ,Male ,Reference Values ,Tumor Necrosis Factor-alpha ,aneurysm ,aorta ,echocardiography ,HIV ,inflammation ,vascular disease ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background The prevalence and extent of subclinical large vessel vasculopathy is not well defined among people living with HIV. We aimed to evaluate associations between aortic root and ascending aortic sizes measured by 2-dimensional transthoracic echocardiography and HIV serostatus, and to identify risk factors for larger aortic sizes among men with HIV, including levels of circulating inflammatory markers. Methods and Results Using clinical and echocardiographic data from the MACS (Multicenter AIDS Cohort Study), adjusted multivariable linear and logistic regression was performed. Four segments of the proximal aorta were measured: aortic annulus, aortic root at the sinuses of Valsalva, sinotubular junction, and ascending aorta. HIV infection was associated with significantly larger aortic root (0.03 cm [95% CI, 0.002-0.06 cm]) and ascending aorta (0.04 cm [95% CI, 0.01-0.06 cm]) diameters. Higher standardized nadir CD4 (cluster of differentiation 4) T-cell count was significantly associated with smaller aortic root (-0.03 cm [95% CI, -0.05 to -0.01 cm]), sinotubular junction (-0.03 cm [95% CI, -0.05 to -0.01 cm]), and ascending aorta (-0.03 cm [95% CI, -0.05 to -0.004 cm]) diameters. Higher levels of standardized TNF-α (tumor necrosis factor-α) were associated with larger diameters of the aortic annulus (0.02 cm [95% CI, 0.003-0.04 cm]) and sinotubular junction (0.02 cm [95% CI, 0.002-0.04 cm]). There were no other cardiovascular or HIV disease severity-related risk factors associated with the aortic dimensions. Conclusions HIV infection is an independent risk factor for greater ascending aortic sizes. Lower nadir CD4 T-cell count and higher TNF-α levels are associated with larger aortic sizes in men with HIV. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT00046280.
- Published
- 2022
14. The Effect of Discrimination and Resilience on Depressive Symptoms Among Middle-Aged and Older Men Who Have Sex With Men
- Author
-
Brown, Andre L, Matthews, Derrick D, Meanley, Steven, Brennan-Ing, Mark, Haberlen, Sabina, D’Souza, Gypsyamber, Ware, Deanna, Egan, James, Shoptaw, Steve, Teplin, Linda A, Friedman, Mackey R, and Plankey, Michael
- Subjects
Public Health ,Health Sciences ,Depression ,Mental Health ,Behavioral and Social Science ,Sexual and Gender Minorities (SGM/LGBT*) ,Aging ,discrimination ,depression ,resilience ,aging ,men who have sex with men ,Discrimination ,Men who have Sex with Men ,Resilience ,Public health ,Clinical and health psychology - Abstract
This study investigated if homophobic and racist discrimination increased depressive symptoms among 960 middle-aged and older men who have sex with men (MSM) and how resilience moderated these relationships. We used five waves of longitudinal data from the Healthy Aging sub-study of the Multicenter AIDS Cohort Study (MACS). We used linear regression analyses to model depressive symptoms as a function of discrimination. We used linear mixed analyses to model changes in mean resilience scores across visits. We used linear regression analyses to model depressive symptoms as a function of changes in resilience and to test the moderation effects of resilience on the relationship between discrimination and depressive symptoms. The models accounted for repeated measures of resilience. Men who experienced external and internal homophobia had greater depressive symptoms (β: 2.08; 95% Confidence Interval: 0.65, 3.51; β: 1.60; 95% Confidence Interval: 0.76, 2.44). Men experienced significant changes in mean resilience levels across visits (F = 2.84, p = 0.02). Men with a greater positive change in resilience had lower depressive symptoms (β: -0.95; 95% Confidence Interval: -1.47, -0.43). Men with higher average resilience levels had lower depressive symptoms (β: -5.08; 95% Confidence Interval: -5.68, -4.49). Men's resilience did not moderate the relationship between homophobia and depressive symptoms. Significant associations of external and internal homophobia with greater depressive symptoms present targets for future research and interventions among middle-aged and older MSM. Significant associations of average and positive changes in resilience with lower depressive symptoms provide aims for future research and interventions with this population.
- Published
- 2022
15. Coronary artery plaque progression and cardiovascular risk scores in men with and without HIV-infection
- Author
-
Shaikh, Kashif, Bhondoekhan, Fiona, Haberlen, Sabina, Nakanishi, Rine, Roy, Sion K, Alla, Venkata M, Brown, Todd T, Lee, Juhwan, Osawa, Kazuhiro, Almeida, Shone, Rahmani, Sina, Nezarat, Negin, Sheidaee, Nasim, Kim, Michael, Jayawardena, Eranthi, Kim, Nicolas, Hathiramani, Nicolai, Palella, Frank J, Witt, Mallory, Ahmad, Khadije, Kingsley, Lawrence, Post, Wendy S, and Budoff, Matthew J
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Aging ,Heart Disease - Coronary Heart Disease ,Sexually Transmitted Infections ,Atherosclerosis ,Infectious Diseases ,Prevention ,Cardiovascular ,Heart Disease ,HIV/AIDS ,Clinical Research ,Infection ,Good Health and Well Being ,Cardiovascular Diseases ,Cohort Studies ,Coronary Angiography ,Coronary Artery Disease ,Coronary Vessels ,HIV Infections ,Heart Disease Risk Factors ,Humans ,Male ,Plaque ,Atherosclerotic ,Risk Factors ,calcified plaque ,cardiovascular disease risk ,HIV ,noncalcified plaque ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveThe aim of this study was to assess the association of cardiovascular disease (CVD) risk scores and coronary artery plaque (CAP) progression in HIV-infected participants.MethodsWe studied men with and without HIV-infection enrolled in the Multicenter AIDS Cohort Study (MACS) CVD study. CAP at baseline and follow-up was assessed with cardiac computed tomography angiography (CCTA). We examined the association between baseline risk scores including pooled cohort equation (PCE), Framingham risk score (FRS), and Data collect of Adverse effects of anti-HIV drugs equation (D:A:D) and CAP progression.ResultsWe studied 495 men (211 HIV-uninfected, 284 HIV-infected). The adjusted odds ratio (aOR) of total plaque volume (TPV) and noncalcified plaque volume (NCPV) progression in the highest relative to lowest tertile was 9.4 [95% confidence interval (95% CI) 2.4-12.1, P
- Published
- 2022
16. Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV
- Author
-
Lai, Mason, Madden, Erin, Shlipak, Michael G., Scherzer, Rebecca, Post, Wendy S., Vittinghoff, Eric, Haberlen, Sabina, Brown, Todd T., Wolinsky, Steven M., Witt, Mallory D., Ho, Ken, Abraham, Alison G., Parikh, Chirag R., Budoff, Matthew, and Estrella, Michelle M.
- Published
- 2024
- Full Text
- View/download PDF
17. Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study.
- Author
-
Sarkar, Sudipa, Haberlen, Sabina, Post, Wendy S, Kelesidis, Theodoros, Wiley, Dorothy, Kingsley, Lawrence, Kim, Eun-Young, Palella, Frank J, Witt, Mallory D, Budoff, Matthew J, Rodriguez, Annabelle, and Brown, Todd T
- Subjects
Biomedical and Clinical Sciences ,Immunology ,Aging ,Cardiovascular ,HIV/AIDS ,Infectious Diseases ,Atherosclerosis ,Sexually Transmitted Infections ,Prevention ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Clinical Research ,Infection ,Good Health and Well Being ,Acquired Immunodeficiency Syndrome ,Antigens ,CD ,Cohort Studies ,Coronary Artery Disease ,HIV Infections ,Humans ,Lymphocyte Activation ,Male ,Lymphocyte Activation Gene 3 Protein ,LAG3 ,cardiovascular disease ,HIV ,Clinical Sciences ,Virology ,Clinical sciences - Abstract
Chronic inflammation, including among people with HIV (PWH), elevates immune cell expression of lymphocyte activation gene 3 (LAG3); however, low plasma LAG3 predicts cardiovascular disease (CVD) events in the general population. The associations among LAG3 plasma levels, subclinical atherosclerosis, inflammation, and HIV infection have not been well described. We measured plasma LAG3 in 704 men with and without HIV from the multicenter AIDS cohort study, who underwent coronary computed tomography angiography. HIV serostatus was not independently associated with LAG3 after adjustment for sociodemographic and CVD risk factors. Current smoking status and African American race were associated with lower LAG3, and age and sTNFαRI concentration were associated with greater LAG3. LAG3 was not associated with coronary artery stenosis. Thus, no difference was found in plasma LAG3 concentration by HIV serostatus, and no association between LAG3 and subclinical coronary atherosclerosis in men with and without HIV was observed.
- Published
- 2021
18. Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2‐Dimensional Echocardiography in the Multicenter AIDS Cohort Study
- Author
-
de Vasconcellos, Henrique Doria, Post, Wendy S, Ervin, Ann‐Margret, Haberlen, Sabina Annette, Budoff, Matthew, Malvestutto, Carlos, Magnani, Jared W, Feinstein, Matthew J, Brown, Todd T, Lima, Joao AC, and Wu, Katherine C
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Clinical Research ,HIV/AIDS ,Biomedical Imaging ,Heart Disease ,Cardiovascular ,Prevention ,Good Health and Well Being ,Acquired Immunodeficiency Syndrome ,Aged ,Cross-Sectional Studies ,Echocardiography ,Female ,Follow-Up Studies ,HIV ,HIV Antibodies ,Heart Failure ,Heart Ventricles ,Humans ,Male ,Middle Aged ,Prospective Studies ,Stroke Volume ,Ventricular Function ,Left ,antiretroviral therapy ,atria ,cardiac remodeling ,diastolic dysfunction ,echocardiography ,AIDS ,subclinical cardiovascular disease ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background We aimed to investigate whether there are differences in cardiac structure and systolic and diastolic function evaluated by 2-dimensional echocardiography among men living with versus without HIV in the era of combination antiretroviral therapy. Methods and Results We performed a cross-sectional analysis of 1195 men from MACS (Multicenter AIDS Cohort Study) who completed a transthoracic echocardiogram examination between 2017 and 2019. Associations between HIV serostatus and echocardiographic indices were assessed by multivariable regression analyses, adjusting for demographics and cardiovascular risk factors. Among men who are HIV+, associations between HIV disease severity markers and echocardiographic parameters were also investigated. Average age was 57.1±11.9 years; 29% of the participants were Black, and 55% were HIV+. Most men who were HIV+ (77%) were virally suppressed; 92% received combination antiretroviral therapy. Prevalent left ventricular (LV) systolic dysfunction (ejection fraction
- Published
- 2021
19. Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2-Dimensional Echocardiography in the Multicenter AIDS Cohort Study.
- Author
-
Doria de Vasconcellos, Henrique, Post, Wendy S, Ervin, Ann-Margret, Haberlen, Sabina Annette, Budoff, Matthew, Malvestutto, Carlos, Magnani, Jared W, Feinstein, Matthew J, Brown, Todd T, Lima, Joao AC, and Wu, Katherine C
- Subjects
HIV/AIDS ,antiretroviral therapy ,atria ,cardiac remodeling ,diastolic dysfunction ,echocardiography ,subclinical cardiovascular disease ,HIV ,AIDS ,Cardiorespiratory Medicine and Haematology - Abstract
Background We aimed to investigate whether there are differences in cardiac structure and systolic and diastolic function evaluated by 2-dimensional echocardiography among men living with versus without HIV in the era of combination antiretroviral therapy. Methods and Results We performed a cross-sectional analysis of 1195 men from MACS (Multicenter AIDS Cohort Study) who completed a transthoracic echocardiogram examination between 2017 and 2019. Associations between HIV serostatus and echocardiographic indices were assessed by multivariable regression analyses, adjusting for demographics and cardiovascular risk factors. Among men who are HIV+, associations between HIV disease severity markers and echocardiographic parameters were also investigated. Average age was 57.1±11.9 years; 29% of the participants were Black, and 55% were HIV+. Most men who were HIV+ (77%) were virally suppressed; 92% received combination antiretroviral therapy. Prevalent left ventricular (LV) systolic dysfunction (ejection fraction
- Published
- 2021
20. Association Between Left Ventricular Scar and Ventricular Ectopy in People Living With and Without HIV
- Author
-
Mustapha, Aishat, Peterson, Tess E., Haberlen, Sabina, Plankey, Michael, Palella, Frank, Piggott, Damani A., Margolick, Joseph B., Post, Wendy S., and Wu, Katherine C.
- Published
- 2023
- Full Text
- View/download PDF
21. Viral suppression among middle-aged and aging MSM living with HIV: Partnership type and quality
- Author
-
Penukonda, Vaibhav, Utz, Timothy, Perry, Nicholas S, Ware, Deanna, Brennan-Ing, Mark, Meanley, Steven, Brown, Andre, Haberlen, Sabina, Egan, James, Shoptaw, Steven, Teplin, Linda A, Friedman, M Reuel, and Plankey, Michael
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Behavioral and Social Science ,Aging ,HIV/AIDS ,Infectious Diseases ,Clinical Trials and Supportive Activities ,Clinical Research ,Infection ,Adult ,Aged ,Cohort Studies ,HIV Infections ,Homosexuality ,Male ,Humans ,Male ,Middle Aged ,Quality of Life ,Sexual Behavior ,Sexual Partners ,Sexual and Gender Minorities ,Viral Load ,General Science & Technology - Abstract
Functional support-the availability of material aid, emotional support, or companionship-promotes general well-being. For men who have sex with men (MSM) living with HIV, having a person who supports you associates with viral suppression. This study examines the association between supportive partnerships and HIV viral suppression among middle-aged and aging MSM living with HIV. A total of 423 middle-aged and aging MSM (mean age, 58.2 years) from the Multicenter AIDS Cohort Study provided self-reported data about their partnerships. Separate Poisson regression models assessed how partnership type, support, strain, and duration from April 2017 were associated with repeated viral load measurements up to April 2019. Of the follow-up visits (N = 1289), 90.0% of participants were virally suppressed. Most participants reported being non-Hispanic White (61.0%) and college-educated (83.4%). Participants were asked about their primary partnerships (i.e., "someone they are committed to above anyone else") and secondary partnerships (i.e., those who can also be intimate or supportive but not necessarily romantic or sexual). The participants reported: no partnerships (45.2%), only primary partnerships (31.0%), only secondary partnerships (11.1%), or both primary and secondary partnerships (12.8%). Primary and secondary partnerships had mean (SD) durations of 15.9 (11.3) and 25.2 (16.5) years, respectively. Participants reporting both primary and secondary partnerships (compared with no partnership) showed significantly higher odds of being virally suppressed (adjusted prevalence ratio [aPR], 1.04; 95% CI, 1.00-1.08; p = 0.043). Albeit not statistically significant, primary-only (aPR, 1.01; 95% CI, 0.97-1.06; p = 0.547) or secondary-only (aPR, 1.03; 95% CI, 0.98-1.08; p = 0.224) partnership types were positively associated with viral suppression. Partner support and strain were not associated with viral suppression in any partnership group. Being older and non-Hispanic Black were positively and negatively associated with viral suppression, respectively. Encouraging partnerships should be considered one of clinicians' many tools to help middle-aged and aging MSM achieve long-term viral suppression.
- Published
- 2021
22. Syndemic trajectories of heavy drinking, smoking, and depressive symptoms are associated with mortality in women living with HIV in the United States from 1994 to 2017
- Author
-
Chichetto, Natalie E., Gebru, Nioud M., Plankey, Michael W., Tindle, Hilary A., Koethe, John R., Hanna, David B., Shoptaw, Steven, Jones, Deborah L., Lazar, Jason M., Kizer, Jorge R., Cohen, Mardge H., Haberlen, Sabina A., Adimora, Adaora A., Lahiri, Cecile D., Wise, Jenni M., and Freiberg, Matthew S.
- Published
- 2023
- Full Text
- View/download PDF
23. Abstract 15132: Proteomic Signatures of Human Immunodeficiency Virus-Associated Subclinical Left Atrial Dilation
- Author
-
Peterson, Tess E, Hahn, Virginia S, Haberlen, Sabina, Plankey, Michael, Palella, Frank, Bader, Joel, Margolick, Joseph, Kirk, Gregory, Piggott, Damani, Brown, Todd T, Post, Wendy S, and Wu, Katherine C
- Published
- 2023
- Full Text
- View/download PDF
24. Abstract 12041: Coronary Artery Calcium and All-Cause Mortality in the Multicenter Aids Cohort Study: MACS
- Author
-
Suzuki, Takahiro, Haberlen, Sabina, Peterson, Tess E, Palella, Frank, Budoff, Matthew, Witt, Mallory D, Magnani, Jared W, and Post, Wendy S
- Published
- 2023
- Full Text
- View/download PDF
25. Associations between QT interval subcomponents, HIV serostatus, and inflammation
- Author
-
Wu, Katherine C, Bhondoekhan, Fiona, Haberlen, Sabina A, Ashikaga, Hiroshi, Brown, Todd T, Budoff, Matthew J, D'Souza, Gypsyamber, Magnani, Jared W, Kingsley, Lawrence A, Palella, Frank J, Margolick, Joseph B, Martínez‐Maza, Otoniel, Altekruse, Sean F, Soliman, Elsayed Z, and Post, Wendy S
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,HIV/AIDS ,Prevention ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Adult ,Aged ,Biomarkers ,Electrocardiography ,HIV Infections ,Humans ,Inflammation ,Long QT Syndrome ,Longitudinal Studies ,Male ,Middle Aged ,Prospective Studies ,Risk Factors ,arrhythmias ,electrocardiography ,HIV ,inflammation ,QT interval ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundThe total QT interval comprises both ventricular depolarization and repolarization currents. Understanding how HIV serostatus and other risk factors influence specific QT interval subcomponents could improve our mechanistic understanding of arrhythmias.MethodsTwelve-lead electrocardiograms (ECGs) were acquired in 774 HIV-infected (HIV+) and 652 HIV-uninfected (HIV-) men from the Multicenter AIDS Cohort Study. Individual QT subcomponent intervals were analyzed: R-onset to R-peak, R-peak to R-end, JT segment, T-onset to T-peak, and T-peak to T-end. Using multivariable linear regressions, we investigated associations between HIV serostatus and covariates, including serum concentrations of inflammatory biomarkers such as interleukin-6 (IL-6), and each QT subcomponent.ResultsAfter adjustment for demographics and risk factors, HIV+ versus HIV- men differed only in repolarization phase durations with longer T-onset to T-peak by 2.3 ms (95% CI 0-4.5, p
- Published
- 2020
26. Greater IL-6, D-dimer, and ICAM-1 Levels Are Associated With Lower Small HDL Particle Concentration in the Multicenter AIDS Cohort Study.
- Author
-
Sarkar, Sudipa, Haberlen, Sabina, Whelton, Seamus, E Schneider, Edward, Kingsley, Lawrence, Palella, Frank, Witt, Mallory D, Kelesidis, Theodoros, Rodriguez, Annabelle, Post, Wendy S, and Brown, Todd T
- Subjects
HDL-C ,inflammation ,lipoprotein particles - Abstract
ObjectiveLow HDL cholesterol (HDL-C) is common in people living with HIV infection, which is associated with inflammation, and correlates with greater cardiovascular disease (CVD) risk. Particles of HDL are HDL subfractions, and in some general population studies, higher small HDL particle number (HDL-P) has been associated with lower CVD risk. The objective of this study was to determine whether HIV serostatus and systemic inflammation were associated with small HDL-P in the Multicenter AIDS Cohort Study (MACS).MethodThe MACS is composed of HIV-infected and HIV-uninfected men. Separate linear regression analyses were conducted to evaluate the associations between outcomes (small HDL-P, large HDL-P, total HDL-P, and HDL size) and variables of interest (interleukin-6 [IL-6], D-dimer, and intercellular adhesion molecule-1 [ICAM-1] levels), with adjustment for other CVD risk factors.ResultsThe study population included 553 HIV-infected (88.1% on current ART) and 319 HIV-uninfected men. The mean age was 52.7 years for HIV-infected men and 55.3 years for HIV-uninfected men. In separate models of the study population, higher log IL-6 was associated with lower total and small HDL-P (P < .01 for both), independent of HIV serostatus and CVD risk factors. Similar results were seen with ICAM-1. Positive HIV serostatus was associated with lower small and total HDL-P, adjusted for inflammatory markers.ConclusionsGreater systemic inflammation and HIV infection both were associated with lower atheroprotective small HDL-P. This may be a potential mechanism contributing to increased cardiovascular risk among HIV-infected people.
- Published
- 2019
27. Associations between epicardial, visceral and subcutaneous adipose tissue with diastolic function in men with and without HIV
- Author
-
Goldberg, Rachel L., primary, Peterson, Tess E., additional, Haberlen, Sabina A., additional, Witt, Mallory D., additional, Palella, Frank J., additional, Magnani, Jared W., additional, Brown, Todd T., additional, Lake, Jordan E., additional, Lima, Joao A. C., additional, Budoff, Matt J., additional, Ndumele, Chiadi E., additional, Wu, Katherine C., additional, and Post, Wendy S., additional
- Published
- 2024
- Full Text
- View/download PDF
28. HIV Infection Is Associated with Greater Left Ventricular Mass in the Multicenter AIDS Cohort Study.
- Author
-
Hutchins, Elizabeth, Wang, Ruibin, Rahmani, Sina, Nakanishi, Rine, Haberlen, Sabina, Kingsley, Lawrence, Witt, Mallory D, Palella, Frank Joseph, Jacobson, Lisa, Budoff, Matthew J, and Post, Wendy S
- Subjects
Heart Ventricles ,Humans ,Acquired Immunodeficiency Syndrome ,Atrial Fibrillation ,Cardiomyopathies ,Anti-Retroviral Agents ,CD4 Lymphocyte Count ,Antiretroviral Therapy ,Highly Active ,Risk Factors ,Cross-Sectional Studies ,Ventricular Function ,Left ,Adult ,Aged ,Middle Aged ,Male ,Heart Failure ,AIDS ,HIV ,X-ray computed tomography ,cardiomyopathy ,diastolic ,heart failure ,Heart Disease ,HIV/AIDS ,Clinical Research ,Infectious Diseases ,Clinical Trials and Supportive Activities ,Prevention ,Cardiovascular ,Infection ,Good Health and Well Being ,tomography ,atrial fibrillation ,Clinical Sciences ,Virology - Abstract
HIV infection has been associated with diastolic heart failure and atrial fibrillation. The purpose of this study is to determine whether HIV infection is associated with differences in left ventricular mass (LVM), left ventricular end-diastolic volume (LVEDV), and left atrial volume (LAV) indexed to body surface area (left ventricular mass index, left ventricular end-diastolic volume index [LVEDVI], and left atrial volume index [LAVI], respectively). Cross-sectional study of 721 men [425 HIV-infected (HIV+), 296 HIV-uninfected (HIV-) enrolled in the cardiovascular substudy of the Multicenter AIDS Cohort Study (MACS). Participants underwent cardiac computed tomography imaging. A blinded reader measured LVM, LVEDV, and LAV. We used multivariable linear regression models to evaluate whether LVEDVI, left ventricular mass index (LVMI), and LAVI differed by HIV serostatus, adjusting for demographics and cardiovascular disease risk factors. LVMI was significantly greater in HIV+ compared with HIV- men, with adjusted difference of 2.65 g/m2 (95% confidence interval 0.53-4.77, p
- Published
- 2019
29. Lung Function, Coronary Artery Disease, and Mortality in HIV
- Author
-
Chandra, Divay, Gupta, Aman, Fitzpatrick, Meghan, Haberlen, Sabina A, Neupane, Maniraj, Leader, Joseph K, Kingsley, Lawrence A, Kleerup, Eric, Budoff, Matthew J, Witt, Mallory, Sciurba, Frank C, Post, Wendy S, and Morris, Alison
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Heart Disease ,Atherosclerosis ,Cardiovascular ,Infectious Diseases ,Heart Disease - Coronary Heart Disease ,Lung ,Clinical Research ,HIV/AIDS ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Infection ,Good Health and Well Being ,Adult ,CD4 Lymphocyte Count ,Carbon Monoxide ,Case-Control Studies ,Comorbidity ,Coronary Artery Disease ,Coronary Vessels ,Endothelin-1 ,Female ,Forced Expiratory Volume ,HIV Infections ,Humans ,Intercellular Adhesion Molecule-1 ,Male ,Middle Aged ,Mortality ,Odds Ratio ,Pulmonary Diffusing Capacity ,Pulmonary Emphysema ,Smoking ,Spirometry ,Tomography ,X-Ray Computed ,United States ,Vascular Calcification ,Viral Load ,HIV ,coronary artery disease ,mortality ,endothelial dysfunction ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Rationale: Impaired lung function is a potent independent predictor of coronary artery disease (CAD) in individuals without human immunodeficiency virus (HIV) infection; however, the relationship between lung function and CAD in HIV remains undefined. Objectives: To examine the relationship between lung function, CAD, mortality, and circulating biomarkers in HIV. Methods: Spirometry, diffusing capacity of the lung for carbon monoxide (DlCO), emphysema, coronary artery calcium, mortality, cause of death, and biomarkers were examined in HIV-infected and uninfected individuals enrolled in a cohort study at the University of Pittsburgh. Results were then validated in the Multicenter AIDS Cohort Study (MACS) cohort. Results: We examined data on 234 participants in the Pittsburgh cohort. The mean ± standard deviation age was 49.5 ± 10.2 years old, 82.1% were male, and 67.5% were ever smokers. Among the 177 of 234 individuals with HIV infection, lower DlCO (not forced expiratory volume in 1 second or emphysema) was independently associated with greater coronary artery calcium (odds ratio, 1.43 per 10% lower DlCO; 95% confidence interval, 1.14-1.81). HIV-infected individuals with both reduced DlCO and coronary artery calcium had a much higher mortality than those with either low DlCO or coronary calcium alone or with neither condition. Endothelin-1, a circulating biomarker of endothelial dysfunction, was associated with both lower DlCO and greater coronary artery calcium in those with HIV infection. Results were reproducible in 144 individuals enrolled in the MACS cohort; intercellular adhesion molecule 1 was the biomarker of endothelial dysfunction assessed in the MACS cohort. Conclusions: Impaired DlCO and CAD were associated with each other and with higher mortality in individuals with HIV infection.
- Published
- 2019
30. Predictors of electrocardiographic QT interval prolongation in men with HIV
- Author
-
Wu, Katherine C, Zhang, Long, Haberlen, Sabina A, Ashikaga, Hiroshi, Brown, Todd T, Budoff, Matthew J, D'Souza, Gypsyamber, Kingsley, Lawrence A, Palella, Frank J, Margolick, Joseph B, Martínez-Maza, Otoniel, Soliman, Elsayed Z, and Post, Wendy S
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Heart Disease ,Cardiovascular ,HIV/AIDS ,Clinical Research ,Prevention ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Adult ,Anti-Retroviral Agents ,B-Cell Activating Factor ,Biomarkers ,Correlation of Data ,Death ,Sudden ,Cardiac ,Electrocardiography ,HIV Infections ,Humans ,Intercellular Adhesion Molecule-1 ,Interleukin-6 ,Long QT Syndrome ,Male ,Middle Aged ,Risk Assessment ,Risk Factors ,Serologic Tests ,United States ,cardiac risk factors and prevention ,electrocardiography ,inflammatory markers ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectiveHIV-infected (HIV+) individuals may be at increased risk for sudden arrhythmic cardiac death. Some studies have reported an association between HIV infection and prolongation of the electrocardiographic QT interval, a measure of ventricular repolarisation, which could potentiate ventricular arrhythmias. We aimed to assess whether HIV+ men have longer QT intervals than HIV-uninfected (HIV-) men and to determine factors associated with QT duration.MethodsWe performed resting 12-lead ECGs in 774 HIV+ and 652 HIV- men in the Multicenter AIDS Cohort Study (MACS). We used multivariable linear and logistic regression analyses to assess associations between HIV serostatus and Framingham corrected QT interval (QTc), after accounting for potential confounders. We also determined associations among QTc interval and HIV-related factors in HIV+ men. In a subgroup of participants, levels of serum markers of inflammation were also assessed.ResultsAfter adjusting for demographics and risk factors, QTc was 4.0 ms longer in HIV+ than HIV- men (p
- Published
- 2019
31. GlycA, a novel inflammatory marker, is associated with subclinical coronary disease
- Author
-
Tibuakuu, Martin, Fashanu, Oluwaseun E, Zhao, Di, Otvos, James D, Brown, Todd T, Haberlen, Sabina A, Guallar, Eliseo, Budoff, Matthew J, Palella, Frank J, Martinson, Jeremy J, Akinkuolie, Akintunde O, Mora, Samia, Post, Wendy S, and Michos, Erin D
- Subjects
Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Aging ,Clinical Research ,Heart Disease ,HIV/AIDS ,Prevention ,Cardiovascular ,Infectious Diseases ,4.1 Discovery and preclinical testing of markers and technologies ,4.2 Evaluation of markers and technologies ,2.1 Biological and endogenous factors ,Detection ,screening and diagnosis ,Aetiology ,Infection ,Good Health and Well Being ,Acute-Phase Proteins ,Adult ,Aged ,Biomarkers ,Coronary Disease ,Cross-Sectional Studies ,Glycosylation ,HIV Infections ,Humans ,Male ,Middle Aged ,Polysaccharides ,Prevalence ,Prospective Studies ,Risk Factors ,Viral Load ,cardiac computed tomography ,coronary artery calcium ,coronary atherosclerosis ,GlycA ,HIV infection ,inflammation ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology - Abstract
ObjectiveGlycA, a novel NMR biomarker of inflammation, has been associated with incident cardiovascular disease (CVD) in the general population, but its association with CVD among HIV-infected individuals is unknown. We examined the associations between GlycA and subclinical coronary plaque among HIV-infected and HIV-uninfected men participating in Multicenter AIDS Cohort Study (MACS).DesignCross-sectional analysis of 935 men with plasma measurement of GlycA and noncontrast cardiac computed tomography (CT) and/or coronary CT angiography.MethodsWe used multivariable Poisson and linear regression to assess associations of GlycA with prevalent coronary atherosclerosis and plaque extent, respectively.ResultsMean ± SD age was 54 ± 7 years; 31% were black; 63% HIV-infected. GlycA levels were higher in HIV-infected compared with HIV-uninfected men (397 ± 68 vs. 380 ± 60 μmol/l, P = 0.0001) and higher for men with detectable viral load vs. undetectable (413 ± 79 vs. 393 ± 65 μmol/l, P = 0.004). After adjusting for HIV serostatus, demographic and CVD risk factors, every 1SD increment in GlycA level was associated with a higher prevalence of coronary artery calcium (CAC >0) [prevalence ratio 1.09 (95% CI 1.03-1.15)] and coronary stenosis at least 50% [1.20 (1.02-1.41)]. These associations were not significantly altered after adjusting for traditional inflammatory biomarkers or differ by HIV serostatus. Among men with plaque, GlycA was positively associated with the extent of CAC and total plaque.ConclusionHIV infection was associated with higher GlycA levels. In both HIV-infected and HIV-uninfected individuals, GlycA was significantly associated with several measures of subclinical coronary atherosclerosis, independent of other CVD risk factors and inflammatory biomarkers. These findings suggest the potential role of GlycA in CVD risk stratification among HIV patients.
- Published
- 2019
32. Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men
- Author
-
Hanna, David B, Moon, Jee-Young, Haberlen, Sabina A, French, Audrey L, Palella, Frank J, Gange, Stephen J, Witt, Mallory D, Kassaye, Seble, Lazar, Jason M, Tien, Phyllis C, Feinstein, Matthew J, Kingsley, Lawrence A, Post, Wendy S, Kaplan, Robert C, Hodis, Howard N, and Anastos, Kathryn
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Atherosclerosis ,Cardiovascular ,Clinical Research ,Behavioral and Social Science ,Aging ,HIV/AIDS ,Heart Disease ,Prevention ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Adult ,Carotid Arteries ,Carotid Intima-Media Thickness ,Carotid Stenosis ,Cohort Studies ,Female ,HIV Infections ,Humans ,Male ,Middle Aged ,Prognosis ,Survival Analysis ,arterial stiffness ,atherosclerosis ,HIV ,intima-media thickness ,mortality ,plaque ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveAmong people with HIV, there are few long-term studies of noninvasive ultrasound-based measurements of the carotid artery predicting major health events. We hypothesized that such measurements are associated with 10-year mortality in the Women's Interagency HIV Study (WIHS) and Multicenter AIDS Cohort Study (MACS), and that associations differ by HIV serostatus.DesignNested cohort study.MethodsParticipants without coronary heart disease underwent B-mode carotid artery ultrasound, with measurement of common carotid artery intima-media thickness (IMT); carotid artery plaque (focal IMT > 1.5 mm) at six locations; and Young's modulus of elasticity, a measure of arterial stiffness. We examined all-cause mortality using Cox models, controlling for demographic, behavioral, cardiometabolic, and HIV-related factors.ResultsAmong 1722 women (median age 40 years, 90% nonwhite, 71% HIV-positive) and 1304 men (median age 50, 39% nonwhite, 62% HIV-positive), 11% died during follow-up. Mortality was higher among HIV-positive women [19.9 deaths/1000 person-years, 95% confidence interval (CI) 14.7-28.8] than HIV-positive men (15.1/1000, 95% CI 8.3-26.8). In adjusted analyses, plaque was associated with mortality (hazard ratio 1.44, 95% CI 1.10-1.88) regardless of HIV serostatus, and varied by sex (among women, hazard ratio 1.06, 95% CI 0.74-1.52; among men; hazard ratio 2.19, 95% CI 1.41-3.43). The association of plaque with mortality was more pronounced among HIV-negative (hazard ratio 3.87, 95% 1.95-7.66) than HIV-positive participants (hazard ratio 1.35, 95% CI 1.00-1.84). Arterial stiffness was also associated with mortality (hazard ratio 1.43 for highest versus lowest quartile, 95% CI 1.02-2.01). Greater common carotid artery-IMT was not associated with mortality.ConclusionCarotid artery plaque was predictive of mortality, with differences observed by sex and HIV serostatus.
- Published
- 2018
33. Suboptimal HIV suppression is associated with progression of coronary artery stenosis: The Multicenter AIDS Cohort Study (MACS) longitudinal coronary CT angiography study
- Author
-
Post, Wendy S., Haberlen, Sabina A., Witt, Mallory D., Zhang, Long, Jacobson, Lisa P., Brown, Todd T., Margolick, Joseph B., Kingsley, Lawrence, Palella, Frank J., Jr., and Budoff, Matthew
- Published
- 2022
- Full Text
- View/download PDF
34. Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV
- Author
-
Peterson, Tess E., Landon, Christian, Haberlen, Sabina A., Bhondoekhan, Fiona, Plankey, Michael W., Palella, Frank J., Piggott, Damani A., Margolick, Joseph B., Brown, Todd T., Post, Wendy S., and Wu, Katherine C.
- Published
- 2022
- Full Text
- View/download PDF
35. Transgender Women With Suppressed Testosterone Display Lower Burden of Coronary Disease Than Matched Cisgender Men.
- Author
-
Lake, Jordan E, Feng, Han, Hyatt, Ana N, Miao, Hongyu, Debroy, Paula, Funderburg, Nicholas, Ailstock, Kate, Dobs, Adrian, Haberlen, Sabina, Magnani, Jared W, Margolick, Joseph B, McGowan, Kate, Palella, Frank J, Witt, Mallory D, Bhasin, Shalender, Budoff, Matthew J, Post, Wendy S, and Brown, Todd T
- Subjects
CORONARY artery stenosis ,TRANS women ,CORONARY artery disease ,CORONARY disease ,HORMONE therapy - Abstract
Context Cardiovascular disease (CVD) in transgender women (TW) may be affected by gender-affirming hormone therapy (GAHT) and HIV, but few data compare TW on contemporary GAHT to well-matched controls. Objective We compared CVD burden and biomarker profiles between TW and matched cisgender men (CM). Methods Adult TW on GAHT (n = 29) were recruited for a cross-sectional study (2018-2020). CM (n = 48) from the former Multicenter AIDS Cohort Study were matched 2:1 to TW on HIV serostatus, age ±5 years, race/ethnicity, BMI category and antiretroviral therapy (ART) type. Cardiac parameters were measured by CT and coronary atherosclerosis by coronary CT angiography; sex hormone and biomarker concentrations were measured centrally from stored samples. Results Overall, median age was 53 years and BMI 29 kg/m
2 ; 69% were non-white. All participants with HIV (71%) had viral suppression on ART. Only 31% of TW had testosterone suppression (<50 ng/dL, TW-S). Traditional CVD risk factors were similar between groups, except that TW-S had higher BMI than TW with non-suppressed testosterone (TW-T). TW-S had no evidence of non-calcified coronary plaque or advanced coronary stenosis, whereas TW-T and CM had similar burden. TW had lower prevalence of any coronary plaque, calcified plaque and mixed plaque than CM, regardless of testosterone concentrations and HIV serostatus. Estradiol but not testosterone concentrations moderately and negatively correlated with the presence of coronary plaque and stenosis. Small sample size limited statistical power. Conclusion Older TW with suppressed total testosterone on GAHT had no CT evidence of non-calcified coronary plaque or advanced coronary stenosis. Longitudinal studies to understand relationships between GAHT and CVD risk in TW are needed. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
36. Barriers and Facilitators to Effective Implementation of the NAMWEZA Intervention in Dar es Salaam, Tanzania
- Author
-
Somba, Magreat, Kaaya, Sylvia, Siril, Hellen, Oljemark, Kicki, Ainebyona, Donald, McAdam, Elspeth, Todd, James, Andrew, Irene, McAdam, Keith, Simwinga, Alice, Mleli, Neema, Makongwa, Samwel, Haberlen, Sabina, and Fawzi, Mary C. Smith
- Published
- 2021
- Full Text
- View/download PDF
37. Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study
- Author
-
Nakanishi, Rine, Post, Wendy S, Osawa, Kazuhiro, Jayawardena, Eranthi, Kim, Michael, Sheidaee, Nasim, Nezarat, Negin, Rahmani, Sina, Kim, Nicholas, Hathiramani, Nicolai, Susarla, Shriraj, Palella, Frank, Witt, Mallory, Blaha, Michael J, Brown, Todd T, Kingsley, Lawrence, Haberlen, Sabina A, Dailing, Christopher, and Budoff, Matthew J
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Biomedical Imaging ,Atherosclerosis ,Aging ,HIV/AIDS ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Cardiovascular ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Acquired Immunodeficiency Syndrome ,Adult ,Aged ,Case-Control Studies ,Cohort Studies ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Disease Progression ,Follow-Up Studies ,HIV Infections ,Humans ,Incidence ,Male ,Middle Aged ,Plaque ,Atherosclerotic ,Prospective Studies ,Vascular Calcification ,coronary artery disease ,coronary computed tomographic angiography ,HIV ,plaque progression ,vulnerable plaque ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Background and aimThe association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).Patients and methodsHIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.ConclusionWe describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
- Published
- 2018
38. Proteomic Signature of HIV-Associated Subclinical Left Atrial Remodeling and Incident Heart Failure
- Author
-
Peterson, Tess Eirene, primary, Hahn, Virginia Shalkey, additional, Moaddel, Ruin, additional, Zhu, Min, additional, Haberlen, Sabina A., additional, Palella, Frank J., additional, Plankey, Michael, additional, Bader, Joel S, additional, Lima, Joao A.C., additional, Gerszten, Robert E, additional, Rotter, Jerome I. I., additional, Rich, Stephen S. S., additional, Heckbert, Susan R., additional, Kirk, Gregory D., additional, Piggott, Damani A, additional, Ferrucci, Luigi, additional, Margolick, Joseph, additional, Brown, Todd T., additional, Wu, Katherine C., additional, and Post, Wendy S., additional
- Published
- 2024
- Full Text
- View/download PDF
39. Social-environmental resiliencies protect against loneliness among HIV-Positive and HIV- negative older men who have sex with men: Results from the Multicenter AIDS Cohort Study (MACS)
- Author
-
De Jesus, Maria, Ware, Deanna, Brown, Andre L., Egan, James E., Haberlen, Sabina A., Palella, Frank Joseph, Jr., Detels, Roger, Friedman, M. Reuel, and Plankey, Michael W.
- Published
- 2021
- Full Text
- View/download PDF
40. Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men
- Author
-
Hanna, David B, Lin, Juan, Post, Wendy S, Hodis, Howard N, Xue, Xiaonan, Anastos, Kathryn, Cohen, Mardge H, Gange, Stephen J, Haberlen, Sabina A, Heath, Sonya L, Lazar, Jason M, Liu, Chenglong, Mack, Wendy J, Ofotokun, Igho, Palella, Frank J, Tien, Phyllis C, Witt, Mallory D, Landay, Alan L, Kingsley, Lawrence A, Tracy, Russell P, and Kaplan, Robert C
- Subjects
Heart Disease ,HIV/AIDS ,Atherosclerosis ,Clinical Research ,Infectious Diseases ,Cardiovascular ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Adult ,Biomarkers ,Carotid Artery Diseases ,Carotid Intima-Media Thickness ,Cohort Studies ,Disease Progression ,Female ,Galectin 3 ,HIV Infections ,Humans ,Inflammation ,Lipopolysaccharide Receptors ,Macrophages ,Male ,Middle Aged ,Monocytes ,Prospective Studies ,atherosclerosis ,galectin-3 ,galectin-3 binding protein ,HIV infection ,inflammation ,intima-media thickness ,macrophages ,monocytes ,soluble CD14 ,soluble CD163 ,soluble CD163. ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundMonocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection.MethodsWe examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years.ResultsMarker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: from 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque.ConclusionssCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.
- Published
- 2017
41. Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study
- Author
-
Chandra, Divay, Gupta, Aman, Leader, Joseph K, Fitzpatrick, Meghan, Kingsley, Lawrence A, Kleerup, Eric, Haberlen, Sabina A, Budoff, Matthew J, Witt, Mallory, Post, Wendy S, Sciurba, Frank C, and Morris, Alison
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,HIV/AIDS ,Clinical Research ,Atherosclerosis ,Prevention ,Heart Disease ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Acquired Immunodeficiency Syndrome ,Calcium ,Cardiac-Gated Imaging Techniques ,Cohort Studies ,Coronary Vessels ,Electrocardiography ,Humans ,Male ,Middle Aged ,Radiography ,Thoracic ,Tomography ,X-Ray Computed ,General Science & Technology - Abstract
RationaleIndividuals with HIV are at increased risk for coronary artery disease (CAD). Early detection of subclinical CAD by assessment of coronary artery calcium (CAC) may help risk stratify and prevent CAD events in these individuals. However, the current standard to quantify CAC i.e. Agatston scoring requires EKG-gated cardiac CT imaging.ObjectiveTo determine if the assessment of CAC using non-EKG-gated chest CT and the Weston scoring system is a useful surrogate for Agatston scores in HIV-infected and HIV-uninfected individuals.Methods and measurementsCAC was assessed by both the Weston and Agatston score in 108 men enrolled in the Multicenter AIDS Cohort Study.ResultsParticipants were 55.2 (IQR 50.4; 59.9) years old and 62 (57.4%) were seropositive for HIV. Inter-observer agreement (rs = 0.94, κ = 90.0%, p
- Published
- 2017
42. Patterns of objectively measured physical activity differ between men living with and without HIV
- Author
-
Etzkorn, Lacey H., Liu, Fangyu, Urbanek, Jacek K., Heravi, Amir S., Magnani, Jared W., Plankey, Michael W., Margolich, Joseph B., Witt, Mallory D., Palella, Frank J., Jr, Haberlen, Sabina A., Wu, Katherine C., Post, Wendy S., Schrack, Jennifer A., and Crainiceanu, Ciprian M.
- Published
- 2022
- Full Text
- View/download PDF
43. Cardiovascular disease risk scores’ relationship to subclinical cardiovascular disease among HIV-infected and HIV-uninfected men
- Author
-
Monroe, Anne K, Haberlen, Sabina A, Post, Wendy S, Palella, Frank J, Kinsgley, Lawrence A, Witt, Mallory D, Budoff, Matthew, Jacobson, Lisa P, and Brown, Todd T
- Subjects
Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Heart Disease ,HIV/AIDS ,Prevention ,Cardiovascular ,Infection ,Good Health and Well Being ,Cardiovascular Diseases ,Coronary Vessels ,Cross-Sectional Studies ,Decision Support Techniques ,HIV Infections ,Humans ,Male ,Middle Aged ,Plaque ,Atherosclerotic ,ROC Curve ,Risk Assessment ,Sensitivity and Specificity ,Tomography ,X-Ray ,cardiac computed tomography ,cardiovascular disease ,HIV ,risk scores ,subclinical atherosclerosis ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology - Abstract
ObjectiveTo study cardiovascular disease risk score utility, we compared the association between Framingham Risk Score (FRS)/pooled cohort equation (PCE) categories and coronary artery plaque presence by HIV serostatus and evaluated whether D : A : D risk category more accurately identifies plaque in HIV-infected men.DesignCross-sectional analysis within a substudy of the Multicenter AIDS Cohort Study.MethodsCardiac computed tomography was performed to assess coronary plaque. We evaluated the association of plaque with increasing cardiovascular disease risk score category, stratified by HIV serostatus, using logistic regression. Receiver operating characteristic curves compared the discrimination of the scores for plaque by HIV serostatus. The sensitivity and specificity of the risk scores were compared in HIV-infected men.ResultsThe risk score category - plaque associations were stronger among HIV-uninfected men than HIV-infected men, except for noncalcified plaque. For example, the odds of coronary artery calcium more than 0 were 7.03 (95% confidence interval 4.21, 11.76) times greater among men in the PCE high-risk versus low-risk category among HIV-uninfected men, compared with just 3.13 (95% confidence interval 2.13, 4.61) times greater among men in the high-risk versus low-risk category among HIV-infected men. Among HIV-infected men, high-risk category by PCE identified the greatest percentage of men with plaque/stenosis, but with lower specificity than D : A : D and FRS. The prevalence of coronary artery calcium more than 0 among men in the PCE low-risk category was 26.5% (HIV-uninfected men) and 36.0% (HIV-infected men).ConclusionsFRS and PCE categories associate with plaque burden better in HIV-uninfected men. No risk score delivered both high sensitivity and specificity among HIV-infected men.
- Published
- 2016
44. Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study.
- Author
-
Bahrami, Hossein, Budoff, Matthew, Haberlen, Sabina A, Rezaeian, Pantea, Ketlogetswe, Kerunne, Tracy, Russell, Palella, Frank, Witt, Mallory D, McConnell, Michael V, Kingsley, Lawrence, and Post, Wendy S
- Subjects
Humans ,HIV Infections ,Coronary Stenosis ,Tumor Necrosis Factor-alpha ,C-Reactive Protein ,Intercellular Adhesion Molecule-1 ,Receptors ,Tumor Necrosis Factor ,Interleukin-6 ,Coronary Angiography ,Adult ,Aged ,Middle Aged ,Male ,Coronary Artery Disease ,Vascular Calcification ,Multimodal Imaging ,Biomarkers ,Computed Tomography Angiography ,HIV ,HIV infection ,atherosclerosis ,cardiac biomarkers ,cardiac computed tomography ,coronary artery calcium ,coronary artery disease ,coronary computed tomography scan ,epidemiology ,inflammation ,Cardiovascular ,HIV/AIDS ,Atherosclerosis ,Heart Disease ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Cardiorespiratory Medicine and Haematology - Abstract
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography.Methods and resultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-α receptor (sTNFαR) I and II (all P
- Published
- 2016
45. Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study
- Author
-
Rezaeian, Panteha, Miller, P Elliott, Haberlen, Sabina A, Razipour, Aryabod, Bahrami, Hossein, Castillo, Romeo, Witt, Mallory D, Kingsley, Lawrence, Palella, Frank J, Nakanishi, Rine, Matsumoto, Suguru, Alani, Anas, Jacobson, Lisa P, Post, Wendy S, and Budoff, Matthew J
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,HIV/AIDS ,Clinical Research ,Infectious Diseases ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Infection ,Good Health and Well Being ,Adult ,Aged ,Aorta ,Thoracic ,Aortic Diseases ,Aortic Valve ,Aortography ,Biomarkers ,Calcinosis ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Coronary Vessels ,HIV Infections ,HIV Seronegativity ,HIV Seropositivity ,Heart Valve Diseases ,Humans ,Inflammation Mediators ,Logistic Models ,Male ,Middle Aged ,Mitral Valve ,Multidetector Computed Tomography ,Multivariate Analysis ,Odds Ratio ,Plaque ,Atherosclerotic ,Prevalence ,Prognosis ,Prospective Studies ,Risk Factors ,United States ,Vascular Calcification ,Extra-coronary calcification ,HIV ,Coronary plaque morphology ,Inflammatory biomarkers ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Applied computing - Abstract
IntroductionPrevious studies have demonstrated an association between HIV infection and coronary artery disease (CAD); little is known about potential associations between HIV infection and extra-coronary calcification (ECC).MethodsWe analyzed 621 HIV infected (HIV+) and 384 HIV uninfected (HIV-) men from the Multicenter AIDS Cohort Study who underwent non-contrast computed tomography (CT) from 2010-2013. Agatston scores were calculated for mitral annular calcification (MAC), aortic valve calcification (AVC), aortic valve ring calcification (AVRC), and thoracic aortic calcification (TAC). The associations between HIV infection and the presence of each type of ECC (score > 0) were evaluated by multivariable logistic regression. We also evaluated the association of ECC with inflammatory biomarker levels and coronary plaque morphology.ResultsAmong HIV+ and HIV- men, the age-standardized prevalences were 15% for TAC (HIV+ 14%/HIV- 16%), 10% for AVC (HIV+ 11%/HIV- 8%), 24% for AVRC (HIV+ 23% HIV- 24%), and 5% for MAC (HIV+ 7%/HIV- 3%). After adjustment, HIV+ men had 3-fold greater odds of MAC compared to HIV- men (OR = 3.2, 95% CI: 1.5-6.7), and almost twice the odds of AVC (1.8, 1.1-2.9). HIV serostatus was not associated with TAC or AVRC. AVRC was associated with higher Il-6 and sCD163 levels. TAC was associated with higher ICAM-1, TNF-α RII, and Il-6 levels. AVC and AVRC calcification were associated with presence of non-calcified plaque in HIV+ but not HIV- men.ConclusionHIV infection is an independent predictor of MAC and AVC. Whether these calcifications predict mortality in HIV+ patients deserves further investigation.
- Published
- 2016
46. Brief Report
- Author
-
Miller, P Elliott, Haberlen, Sabina A, Brown, Todd T, Margolick, Joseph B, DiDonato, Joseph A, Hazen, Stanley L, Witt, Mallory D, Kingsley, Lawrence A, Palella, Frank J, Budoff, Matthew, Jacobson, Lisa P, Post, Wendy S, and Sears, Cynthia L
- Subjects
HIV/AIDS ,Prevention ,Clinical Research ,Nutrition ,Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Cardiovascular ,Good Health and Well Being ,Coronary Stenosis ,Gastrointestinal Microbiome ,HIV Infections ,HIV Seroprevalence ,Humans ,Male ,Methylamines ,Middle Aged ,Prospective Studies ,HIV ,trimethylamine-N-oxide ,coronary artery disease ,Clinical Sciences ,Public Health and Health Services ,Virology - Abstract
Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.
- Published
- 2016
47. Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study)
- Author
-
Brener, Michael I, Post, Wendy S, Haberlen, Sabina A, Zhang, Long, Palella, Frank J, Jacobson, Lisa P, Dobs, Adrian S, George, Richard T, Witt, Mallory D, Budoff, Matthew, Kingsley, Lawrence A, and Brown, Todd T
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Cardiovascular ,Clinical Research ,Atherosclerosis ,Heart Disease ,HIV/AIDS ,Heart Disease - Coronary Heart Disease ,Infection ,Adult ,Aged ,Biomarkers ,Blood Glucose ,Body Mass Index ,Cohort Studies ,Coronary Angiography ,Coronary Artery Disease ,Coronary Stenosis ,HIV Infections ,Humans ,Immunocompromised Host ,Insulin ,Insulin Resistance ,Male ,Middle Aged ,Prevalence ,Prospective Studies ,Risk Assessment ,Tomography ,X-Ray Computed ,United States ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
The relation between insulin resistance (IR) and coronary artery disease in patients with human immunodeficiency virus (HIV) infection remains incompletely defined. Fasting serum insulin and glucose measurements from 448 HIV-infected and 306 uninfected men enrolled in the Multicenter AIDS Cohort Study were collected at semiannual visits from 2003 to 2013 and used to compute the homeostatic model assessment of IR (HOMA-IR). Coronary computed tomographic angiography (CTA) was performed at the end of the study period to characterize coronary pathology. Associations between HOMA-IR (categorized into tertiles and assessed near the time of the CTA and over the 10-year study period) and the prevalence of coronary plaque or stenosis ≥50% were assessed with multivariate logistic regression. HOMA-IR was higher in HIV-infected men than HIV-uninfected men when measured near the time of CTA (3.2 vs 2.7, p = 0.002) and when averaged over the study period (3.4 vs 3.0, p
- Published
- 2016
48. A Cross-sectional Study of the Association Between Chronic Hepatitis C Virus Infection and Subclinical Coronary Atherosclerosis Among Participants in the Multicenter AIDS Cohort Study
- Author
-
McKibben, Rebeccah A, Haberlen, Sabina A, Post, Wendy S, Brown, Todd T, Budoff, Matthew, Witt, Mallory D, Kingsley, Lawrence A, Palella, Frank J, Thio, Chloe L, and Seaberg, Eric C
- Subjects
Heart Disease ,Prevention ,Chronic Liver Disease and Cirrhosis ,Cardiovascular ,Atherosclerosis ,Liver Disease ,Infectious Diseases ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Emerging Infectious Diseases ,Hepatitis ,Hepatitis - C ,Digestive Diseases ,HIV/AIDS ,Infection ,Good Health and Well Being ,Adult ,Cohort Studies ,Coronary Artery Disease ,Cross-Sectional Studies ,HIV Infections ,Hepatitis C ,Chronic ,Humans ,Male ,Middle Aged ,Risk Factors ,United States ,atherosclerosis ,cardiovascular disease ,hepatitis C virus infection ,human immunodeficiency virus type 1 ,plaque ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundHepatitis C virus (HCV) infection may increase the risk of cardiovascular disease (CVD). We evaluated the association of chronic HCV infection and coronary atherosclerosis among participants in the Multicenter AIDS Cohort Study.MethodsWe assessed 994 men with or without human immunodeficiency virus (HIV) infection (87 of whom had chronic HCV infection) for coronary plaque, using noncontrast coronary computed tomography (CT); 755 also underwent CT angiography. We then evaluated the associations of chronic HCV infection and HIV infection with measures of plaque prevalence, extent, and stenosis.ResultsAfter adjustment for demographic characteristics, HIV serostatus, behaviors, and CVD risk factors, chronic HCV infection was significantly associated with a higher prevalence of coronary artery calcium (prevalence ratio, 1.29; 95% confidence interval [CI], 1.02-1.63), any plaque (prevalence ratio, 1.26; 95% CI, 1.09-1.45), and noncalcified plaque (prevalence ratio, 1.42; 95% CI, 1.16-1.75). Chronic HCV infection and HIV infection were independently associated with the prevalence of any plaque and of noncalcified plaque, but there was no evidence of a synergistic effect due to HIV/HCV coinfection. The prevalences of coronary artery calcium, any plaque, noncalcified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantly higher among men with an HCV RNA load of ≥2 × 10(6) IU/mL, compared with findings among men without chronic HCV infection.ConclusionsChronic HCV infection is associated with subclinical CVD, suggesting that vigilant assessments of cardiovascular risk are warranted for HCV-infected individuals. Future research should determine whether HCV infection duration or HCV treatment influence coronary plaque development.
- Published
- 2016
49. Gut Microbial-Related Choline Metabolite Trimethylamine- N -Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection
- Author
-
Shan, Zhilei, Clish, Clary B., Hua, Simin, Scott, Justin M., Hanna, David B., Burk, Robert D., Haberlen, Sabina A., Shah, Sanjiv J., Margolick, Joseph B., Sears, Cynthia L., Post, Wendy S., Landay, Alan L., Lazar, Jason M., Hodis, Howard N., Anastos, Kathryn, Kaplan, Robert C., and Qi, Qibin
- Published
- 2018
50. Characterizing Experiences of Conversion Therapy Among Middle-Aged and Older Men Who Have Sex with Men from the Multicenter AIDS Cohort Study (MACS)
- Author
-
Meanley, Steven P., Stall, Ron D., Dakwar, Omar, Egan, James E., Friedman, Mackey R., Haberlen, Sabina A., Okafor, Chukwuemeka, Teplin, Linda A., and Plankey, Michael W.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.