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4. In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group

Author

Haukvik, Unn K, Gurholt, Tiril P, Nerland, Stener, Elvsåshagen, Torbjørn, Akudjedu, Theophilus N, Alda, Martin, Alnæs, Dag, Alonso‐Lana, Silvia, Bauer, Jochen, Baune, Bernhard T, Benedetti, Francesco, Berk, Michael, Bettella, Francesco, Bøen, Erlend, Bonnín, Caterina M, Brambilla, Paolo, Canales‐Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz‐Zuluaga, Ana M, Erp, Theo GM, Fatjó‐Vilas, Mar, Foley, Sonya F, Förster, Katharina, Fullerton, Janice M, Goikolea, José M, Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus CM, Haatveit, Beathe, Hajek, Tomas, Hallahan, Brian, Harris, Mathew, Hawkins, Emma L, Howells, Fleur M, Hülsmann, Carina, Jahanshad, Neda, Jørgensen, Kjetil N, Kircher, Tilo, Krämer, Bernd, Krug, Axel, Kuplicki, Rayus, Lagerberg, Trine V, Lancaster, Thomas M, Lenroot, Rhoshel K, Lonning, Vera, López‐Jaramillo, Carlos, Malt, Ulrik F, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meer, Dennis, Melle, Ingrid, Melloni, Elisa MT, Mitchell, Philip B, Nabulsi, Leila, Nenadić, Igor, Oertel, Viola, Oldani, Lucio, Opel, Nils, Otaduy, Maria CG, Overs, Bronwyn J, Pineda‐Zapata, Julian A, Pomarol‐Clotet, Edith, Radua, Joaquim, Rauer, Lisa, Redlich, Ronny, Repple, Jonathan, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salminen, Lauren E, Salvador, Raymond, Sarró, Salvador, Savitz, Jonathan, Schene, Aart H, Sim, Kang, Soeiro‐de‐Souza, Marcio G, Stäblein, Michael, Stein, Dan J, Stein, Frederike, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Veltman, Dick J, Vieta, Eduard, Waltemate, Lena, Westlye, Lars T, Whalley, Heather C, Sämann, Philipp G, Thompson, Paul M, Ching, Christopher RK, Andreassen, Ole A, Agartz, Ingrid, and Group, ENIGMA Bipolar Disorder Working

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Mental Health, Serious Mental Illness, Neurosciences, Biomedical Imaging, Bipolar Disorder, Mental health, Genetics, Hippocampus, Humans, Magnetic Resonance Imaging, Neuroimaging, ENIGMA Bipolar Disorder Working Group, bipolar disorder subtype, hippocampus, large-scale, lithium, psychosis, structural brain MRI, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.

Published
2022

6. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K, Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L, Buitelaar, Jan, Celius, Elisabeth G, Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M, de Quervain, Dominique JF, Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S, Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K, Harbo, Hanne F, Hartman, Catharina A, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jernigan, Terry L, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B, Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A, Smeland, Olav B, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Ulrichsen, Kristine M, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, and Westlye, Lars T

Subjects
Biological Psychology, Psychology, Rare Diseases, Mental Health, Neurosciences, Brain Disorders, Biomedical Imaging, Aging, Aetiology, 2.3 Psychological, social and economic factors, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Neurological, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Brain, Brain Diseases, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuropsychological Tests, Schizophrenia, Sex Characteristics, Young Adult, Karolinska Schizophrenia Project, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Published
2019

8. Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls

Author

Sæther, Linn Sofie, primary, Ueland, Thor, additional, Haatveit, Beathe, additional, Vaskinn, Anja, additional, Flaaten, Camilla Bärthel, additional, Mohn, Christine, additional, Ormerod, Monica B. E.G., additional, Aukrust, Pål, additional, Melle, Ingrid, additional, Steen, Nils Eiel, additional, Andreassen, Ole A., additional, and Ueland, Torill, additional

Published
2024
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12. Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals

Author

Valstad, Mathias, Moberget, Torgeir, Roelfs, Daniël, Slapø, Nora B., Timpe, Clara M.F., Beck, Dani, Richard, Geneviève, Sæther, Linn Sofie, Haatveit, Beathe, Skaug, Knut Andre, Nordvik, Jan Egil, Hatlestad-Hall, Christoffer, Einevoll, Gaute T., Mäki-Marttunen, Tuomo, Westlye, Lars T., Jönsson, Erik G., Andreassen, Ole A., and Elvsåshagen, Torbjørn

Published
2020
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13. Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain

Author

Sæther, Linn Sofie, primary, Szabo, Attila, additional, Akkouh, Ibrahim A., additional, Haatveit, Beathe, additional, Mohn, Christine, additional, Vaskinn, Anja, additional, Aukrust, Pål, additional, Ormerod, Monica B. E.G., additional, Steen, Nils Eiel, additional, Melle, Ingrid, additional, Djurovic, Srdjan, additional, Andreassen, Ole A., additional, Ueland, Torill, additional, and Ueland, Thor, additional

Published
2023
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14. Cognitive and inflammatory subgroups in severe mental illness: translating findings from blood to brain

Author

Sæther, Linn Sofie, primary, Ueland, Thor, additional, Szabo, Attila, additional, Djurovic, Srdjan, additional, Haatveit, Beathe, additional, Aukrust, Pål, additional, Steen, Nils Eiel, additional, Ormerod, Monica Bettina Elkjaer Greenwood, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, and Ueland, Torill, additional

Published
2023
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19. Long-term course of cognitive functioning in bipolar disorder: A ten-year follow-up study.

Author

Flaaten, Camilla Bärthel, Melle, Ingrid, Bjella, Thomas, Engen, Magnus Johan, Åsbø, Gina, Wold, Kristin Fjelnseth, Widing, Line, Gardsjord, Erlend, Øie, Merete Glenne, Lyngstad, Siv Hege, Haatveit, Beathe, Simonsen, Carmen, and Ueland, Torill

Subjects
COGNITIVE ability, COGNITIVE processing speed, BIPOLAR disorder, COGNITION, SHORT-term memory, VERBAL memory, PSYCHOTIC depression
Abstract

Introduction: Cognitive impairments are common in bipolar disorder (BD), but the long-term course remains understudied. Longitudinal data on cognitive functioning from the start of the first treatment could help clarify pathophysiological processes that shape the illness outcome. We here aim to investigate the 10-year cognitive course in BD compared to healthy controls (HC) and the effects of clinical symptoms on cognitive trajectories. Methods: Fifty-six BD participants recruited within their first year of treatment and 108 HC completed clinical and cognitive assessments at baseline and 10-year followup. We derived eight cognitive domain scores and a cognitive composite score, which were further investigated using linear mixed model analyses. Correlation analyses were used to assess associations between the composite score and depressive, manic and psychotic symptoms. Results: BD participants performed poorer than HCs in all domains except mental speed and verbal fluency. Verbal learning and memory, verbal fluency and the composite score improved over time in both BD participants and HC, while short-term memory, mental speed, psychomotor speed and working memory were stable. We found no significant correlations between cognition and symptom level at either time point in BD participants. Conclusions: We found evidence of long-term cognitive stability or improvement in BD participants from first treatment to 10-year follow-up. Though the BD group was impaired in all domains except mental speed and verbal fluency, the change in cognitive functioning was parallel to that of HCs. These findings are not consistent with the notion of neuroprogression in BD. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Altered Sex Differences in Hippocampal Subfield Volumes in Schizophrenia.

Author

Barth, Claudia, Nerland, Stener, Jørgensen, Kjetil N, Haatveit, Beathe, Wortinger, Laura A, Melle, Ingrid, Haukvik, Unn K, Ueland, Torill, Andreassen, Ole A, and Agartz, Ingrid

Subjects
HIPPOCAMPUS physiology, HIPPOCAMPUS (Brain), SEX differentiation disorders, SCHIZOPHRENIA, MULTIPLE regression analysis, RISK assessment, COMPARATIVE studies, ANALYSIS of covariance, RESEARCH funding, BIPOLAR disorder, DISEASE risk factors, DISEASE complications
Abstract

Background and Hypothesis The hippocampus is a heterogenous brain structure that differs between the sexes and has been implicated in the pathophysiology of psychiatric illnesses. Here, we explored sex and diagnostic group differences in hippocampal subfield volumes, in individuals with schizophrenia spectrum disorder (SZ), bipolar disorders (BD), and healthy controls (CTL). Study Design One thousand and five hundred and twenty-one participants underwent T1-weighted magnetic resonance imaging (SZ, n  = 452, mean age 30.7 ± 9.2 [SD] years, males 59.1%; BD, n  = 316, 33.7 ± 11.4, 41.5%; CTL, n  = 753, 34.1 ± 9.1, 55.6%). Total hippocampal, subfield, and intracranial volumes were estimated with Freesurfer (v6.0.0). Analysis of covariance and multiple regression models were fitted to examine sex-by-diagnostic (sub)group interactions in volume. In SZ and BD, separately, associations between volumes and clinical as well as cognitive measures were examined between the sexes using regression models. Study Results Significant sex-by-group interactions were found for the total hippocampus, dentate gyrus, molecular layer, presubiculum, fimbria, hippocampal-amygdaloid transition area, and CA4, indicating a larger volumetric deficit in male patients relative to female patients when compared with same-sex CTL. Subgroup analyses revealed that this interaction was driven by males with schizophrenia. Effect sizes were overall small (partial η < 0.02). We found no significant sex differences in the associations between hippocampal volumes and clinical or cognitive measures in SZ and BD. Conclusions Using a well-powered sample, our findings indicate that the pattern of morphological sex differences in hippocampal subfields is altered in individuals with schizophrenia relative to CTL, due to higher volumetric deficits in males. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Long‐term course of cognitive functioning in bipolar disorder: A ten‐year follow‐up study

Author

Flaaten, Camilla Bärthel, primary, Melle, Ingrid, additional, Bjella, Thomas, additional, Engen, Magnus Johan, additional, Åsbø, Gina, additional, Wold, Kristin Fjelnseth, additional, Widing, Line, additional, Gardsjord, Erlend, additional, Øie, Merete Glenne, additional, Lyngstad, Siv Hege, additional, Haatveit, Beathe, additional, Simonsen, Carmen, additional, and Ueland, Torill, additional

Published
2023
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24. Long-term Outcomes of People With DSM Psychotic Disorder NOS

Author

Widing, Line, primary, Simonsen, Carmen, additional, Bjella, Thomas, additional, Engen, Magnus Johan, additional, Flaaten, Camilla Bärthel, additional, Gardsjord, Erlend, additional, Haatveit, Beathe, additional, Haug, Elisabeth, additional, Lyngstad, Siv Hege, additional, Svendsen, Ingrid Hartveit, additional, Vik, Ruth Kristine, additional, Wold, Kristin Fjelnseth, additional, Åsbø, Gina, additional, Ueland, Torill, additional, and Melle, Ingrid, additional

Published
2023
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26. Inflammation and cognition in severe mental illness: patterns of covariation and subgroups

Author

Sæther, Linn Sofie, primary, Ueland, Thor, additional, Haatveit, Beathe, additional, Maglanoc, Luigi Angelo, additional, Szabo, Attila, additional, Djurovic, Srdjan, additional, Aukrust, Pål, additional, Roelfs, Daniel, additional, Mohn, Christine, additional, Ormerod, Monica Bettina Elkjaer Greenwood, additional, Lagerberg, Trine Vik, additional, Steen, Nils Eiel, additional, Melle, Ingrid, additional, Andreassen, Ole Andreas, additional, and Ueland, Torill, additional

Published
2022
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28. The Time is Ripe for a Consensus Definition of Clinical Recovery in First-episode Psychosis: Suggestions Based on a 10-Year Follow-up Study

Author

Åsbø, Gina, primary, Ueland, Torill, additional, Haatveit, Beathe, additional, Bjella, Thomas, additional, Flaaten, Camilla Bärthel, additional, Wold, Kristin Fjelnseth, additional, Widing, Line, additional, Engen, Magnus Johan, additional, Lyngstad, Siv Hege, additional, Gardsjord, Erlend, additional, Romm, Kristin Lie, additional, Melle, Ingrid, additional, and Simonsen, Carmen, additional

Published
2022
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29. Cognitive and Global Functioning in Patients With First-Episode Psychosis Stratified by Level of Negative Symptoms. A 10-Year Follow-Up Study

Author

Engen, Magnus Johan, primary, Vaskinn, Anja, additional, Melle, Ingrid, additional, Færden, Ann, additional, Lyngstad, Siv Hege, additional, Flaaten, Camilla Bärthel, additional, Widing, Line Hustad, additional, Wold, Kristin Fjelnseth, additional, Åsbø, Gina, additional, Haatveit, Beathe, additional, Simonsen, Carmen, additional, and Ueland, Torill, additional

Published
2022
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30. Course of intellectual functioning in schizophrenia and bipolar disorder: a 10-year follow-up study

Author

Flaaten, Camilla Bärthel, primary, Melle, Ingrid, additional, Gardsjord, Erlend, additional, Bjella, Thomas, additional, Engen, Magnus Johan, additional, Vaskinn, Anja, additional, Åsbø, Gina, additional, Wold, Kristin Fjelnseth, additional, Widing, Line, additional, Lyngstad, Siv Hege, additional, Haatveit, Beathe, additional, Simonsen, Carmen, additional, and Ueland, Torill, additional

Published
2022
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31. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group

Author

Abé, Christoph, primary, Ching, Christopher R.K., additional, Liberg, Benny, additional, Lebedev, Alexander V., additional, Agartz, Ingrid, additional, Akudjedu, Theophilus N., additional, Alda, Martin, additional, Alnæs, Dag, additional, Alonso-Lana, Silvia, additional, Benedetti, Francesco, additional, Berk, Michael, additional, Bøen, Erlend, additional, Bonnin, Caterina del Mar, additional, Breuer, Fabian, additional, Brosch, Katharina, additional, Brouwer, Rachel M., additional, Canales-Rodríguez, Erick J., additional, Cannon, Dara M., additional, Chye, Yann, additional, Dahl, Andreas, additional, Dandash, Orwa, additional, Dannlowski, Udo, additional, Dohm, Katharina, additional, Elvsåshagen, Torbjørn, additional, Fisch, Lukas, additional, Fullerton, Janice M., additional, Goikolea, Jose M., additional, Grotegerd, Dominik, additional, Haatveit, Beathe, additional, Hahn, Tim, additional, Hajek, Tomas, additional, Heindel, Walter, additional, Ingvar, Martin, additional, Sim, Kang, additional, Kircher, Tilo T.J., additional, Lenroot, Rhoshel K., additional, Malt, Ulrik F., additional, McDonald, Colm, additional, McWhinney, Sean R., additional, Melle, Ingrid, additional, Meller, Tina, additional, Melloni, Elisa M.T., additional, Mitchell, Philip B., additional, Nabulsi, Leila, additional, Nenadić, Igor, additional, Opel, Nils, additional, Overs, Bronwyn J., additional, Panicalli, Francesco, additional, Pfarr, Julia-Katharina, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Repple, Jonathan, additional, Ringwald, Kai G., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Salvador, Raymond, additional, Sarink, Kelvin, additional, Sarró, Salvador, additional, Schmitt, Simon, additional, Stein, Frederike, additional, Suo, Chao, additional, Thomopoulos, Sophia I., additional, Tronchin, Giulia, additional, Vieta, Eduard, additional, Westlye, Lars T., additional, White, Adam G., additional, Yatham, Lakshmi N., additional, Zak, Nathalia, additional, Thompson, Paul M., additional, Andreassen, Ole A., additional, and Landén, Mikael, additional

Published
2022
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32. Spatial Frequency Discrimination in Patients with Schizophrenia Spectrum and Bipolar Disorders: Evidence of Early Visual Processing Deficits and Associations with Intellectual Abilities

Author

Løchen, Aili Røtterud, primary, Kolskår, Knut K., additional, de Lange, Ann-Marie G., additional, Sneve, Markus H., additional, Haatveit, Beathe, additional, Lagerberg, Trine V., additional, Ueland, Torill, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Alnæs, Dag, additional

Published
2022
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33. Premorbid characteristics of patients with DSM-IV psychotic disorders

Author

Widing, Line Hustad, Simonsen, Carmen Elisabeth, Flaaten, Camilla Bärthel, Haatveit, Beathe, Vik, Ruth Kristine, Wold, Kristin Fjelnseth, Åsbø, Gina, Ueland, Torill, and Melle, Ingrid

Subjects
Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, Clinical Psychology, Bipolar Disorder, Psychotic Disorders, Schizophrenia, Humans, Social Adjustment, Cannabis
Abstract

Introduction Psychotic disorder not otherwise specified (PNOS) is considered part of the psychosis spectrum, together with schizophrenia spectrum disorders (SSD) and psychotic bipolar spectrum disorders (PBD). The atypical clinical presentations of PNOS conditions may lead to uncertainty regarding treatment choices and expected outcomes. PNOS is understudied, and little is known about patients' premorbid characteristics including premorbid adjustment, prevalence of early cannabis use and childhood trauma. Knowledge about early illness phases can increase our understanding of this diagnostic group. Methods We included 1099 participants from the Norwegian TOP-study; 688 with narrow SSD diagnoses (schizophrenia, schizoaffective disorder, schizophreniform disorder), 274 with PBD (psychotic bipolar 1 and bipolar NOS) and 137 with PNOS diagnosed with the SCID-I for DSM-IV. Participants were assessed with the Premorbid Adjustment Scale (PAS) divided into the areas of premorbid academic and social functioning. We obtained information on age at first exposure to cannabis and use of cannabis before the age of 16. The participants also provided information regarding early traumatic experiences using the Childhood Trauma Questionnaire (CTQ). Results Participants with PNOS and SSD had poorer premorbid academic functioning than those with PBD (F2, 1029 = 7.81, p

Published
2021

35. Spatial frequency discrimination in patients with schizophrenia spectrum and bipolar disorders: Evidence of early visual processing deficits and associations with intellectual abilities

Author

Løchen, Aili R., primary, Kolskår, Knut K., additional, de Lange, Ann-Marie G., additional, Sneve, Markus H., additional, Haatveit, Beathe, additional, Lagerberg, Trine V., additional, Ueland, Torill, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Alnæs, Dag, additional

Published
2021
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37. Time is Ripe for a Consensus Definition of Clinical Recovery in First-episode Psychosis: Suggestions Based on a 10-Year Follow-up Study.

Author

Åsbø, Gina, Ueland, Torill, Haatveit, Beathe, Bjella, Thomas, Flaaten, Camilla Bärthel, Wold, Kristin Fjelnseth, Widing, Line, Engen, Magnus Johan, Lyngstad, Siv Hege, Gardsjord, Erlend, Romm, Kristin Lie, Melle, Ingrid, and Simonsen, Carmen

Subjects
SCHIZOPHRENIA treatment, CONSENSUS (Social sciences), PATIENT aftercare, PSYCHOTHERAPY patients, SCHIZOPHRENIA, CONVALESCENCE, RESEARCH methodology, INTERVIEWING, FUNCTIONAL assessment, COMPARATIVE studies, PSYCHOSOCIAL factors, DESCRIPTIVE statistics, BIPOLAR disorder, DISEASE remission, PSYCHIATRIC treatment, LONGITUDINAL method, SYMPTOMS
Abstract

Objectives A consensus definition of clinical recovery in first-episode psychosis (FEP) is required to improve knowledge about recovery rates in this population. To propose criteria for a future consensus definition, this study aims to investigate rates of clinical recovery when using a standard definition (full psychotic symptom remission and adequate functioning for minimum one year) across both affective and nonaffective FEP groups (bipolar spectrum and schizophrenia spectrum disorders). Second, we aim to explore changes in rates when altering the standard definition criteria. Third, to examine the extent to which healthy controls meet the functioning criteria. Study design In total, 142 FEP participants and 117 healthy controls preselected with strict criteria, were re-assessed with structured clinical interviews at 10-year follow-up. Study results A total of 31.7% were in clinical recovery according to the standard definition, with significantly higher recovery rates in bipolar (50.0%) than in schizophrenia spectrum disorders (22.9%). Both groups' recovery rates decreased equally when extending duration and adding affective symptom remission criteria and increased with looser functioning criteria. In healthy controls, 18.8% did not meet the standard criteria for adequate functioning, decreasing to 4.3% with looser criteria. Conclusions Findings suggest that clinical recovery is common in FEP, although more in bipolar than in schizophrenia spectrum disorders, also when altering the recovery criteria. We call for a future consensus definition of clinical recovery for FEP, and suggest it should include affective symptom remission and more reasonable criteria for functioning that are more in line with the general population. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder

Author

Valstad, Mathias, primary, Roelfs, Daniël, additional, Slapø, Nora B, additional, Timpe, Clara M F, additional, Rai, Ahsan, additional, Matziorinis, Anna Maria, additional, Beck, Dani, additional, Richard, Geneviève, additional, Sæther, Linn Sofie, additional, Haatveit, Beathe, additional, Nordvik, Jan Egil, additional, Hatlestad-Hall, Christoffer, additional, Einevoll, Gaute T, additional, Mäki-Marttunen, Tuomo, additional, Haram, Marit, additional, Ueland, Torill, additional, Lagerberg, Trine V, additional, Steen, Nils Eiel, additional, Melle, Ingrid, additional, Westlye, Lars T, additional, Jönsson, Erik G, additional, Andreassen, Ole A, additional, Moberget, Torgeir, additional, and Elvsåshagen, Torbjørn, additional

Published
2021
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40. Publisher Correction:Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7)

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J.F., Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S., Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jernigan, Terry L., Jonassen, Rune, Jönsson, Erik G., Farde, Lars, Engberg, Göran, Erhardt, Sophie, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K., Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne Marthe, Selbæk, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., and Westlye, Lars T.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

In the version of this article initially published, spaces were missing in the names of Stephanie Le Hellard and Pasquale Di Carlo. The errors have been corrected in the HTML and PDF versions of the article.

Published
2020

42. Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

Author

Valstad, Mathias, primary, Roelfs, Daniël, additional, Slapø, Nora B., additional, Timpe, Clara M.F., additional, Rai, Ahsan, additional, Matziorinis, Anna Maria, additional, Beck, Dani, additional, Richard, Geneviève, additional, Sæther, Linn Sofie, additional, Haatveit, Beathe, additional, Nordvik, Jan Egil, additional, Hatlestad-Hall, Christoffer, additional, Einevoll, Gaute T., additional, Mäki-Marttunen, Tuomo, additional, Haram, Marit, additional, Ueland, Torill, additional, Lagerberg, Trine V., additional, Steen, Nils Eiel, additional, Melle, Ingrid, additional, Westlye, Lars T., additional, Jönsson, Erik G., additional, Andreassen, Ole A., additional, Moberget, Torgeir, additional, and Elvsåshagen, Torbjørn, additional

Published
2020
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44. Experience-dependent modulation of the visual evoked potential: testing effect sizes, retention over time, and associations with age in 415 healthy individuals

Author

Valstad, Mathias, primary, Moberget, Torgeir, additional, Roelfs, Daniël, additional, Slapø, Nora B., additional, Timpe, Clara M.F., additional, Beck, Dani, additional, Richard, Geneviève, additional, Sofie Sæther, Linn, additional, Haatveit, Beathe, additional, Andre Skaug, Knut, additional, Egil Nordvik, Jan, additional, Hatlestad-Hall, Christoffer, additional, Einevoll, Gaute T., additional, Mäki-Marttunen, Tuomo, additional, Westlye, Lars T., additional, Jönsson, Erik G., additional, Andreassen, Ole A., additional, and Elvsåshagen, Torbjørn, additional

Published
2020
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47. S193. Brain Variability in Schizophrenia Spectrum Disorder

Author

Alnaes, Dag, primary, Kaufmann, Tobias, additional, Palomera, Aldo Córdova, additional, Schwarz, Emanuel, additional, van der Meer, Dennis, additional, Moberget, Torgeir, additional, Rokicki, Jarek, additional, Doan, Nhat Trung, additional, Brandt, Christine L., additional, Haatveit, Beathe C., additional, Lund, Martina J., additional, Melle, Ingrid, additional, Agartz, Ingrid, additional, Jönsson, Erik G., additional, Pergola, Giulio, additional, Quarto, Tiziana, additional, De Giorgio, Annabella, additional, Bertolino, Alessandro, additional, Barch, Deanna M., additional, Kirsch, Peter, additional, Lindenberger, Andreas Meyer, additional, Fatouros-Bergmann, Helena, additional, Flyckt, Lena, additional, Consortium, KaSP, additional, Andreassen, Ole A., additional, and Westlye, Lars T., additional

Published
2018
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48. F50. Genetic Architecture of Hippocampal Subfield Volumes: Shared and Specific Influences

Author

van der Meer, Dennis, primary, Kaufmann, Tobias, additional, Córdova-Palomera, Aldo, additional, Bettella, Francesco, additional, Frei, Oleksandr, additional, Doan, N. Trung, additional, Alnæs, Dag, additional, Moberget, Torgeir, additional, Agartz, Ingrid, additional, Bertolino, Alessandro, additional, Brandt, Christine L., additional, Buitelaar, Jan K., additional, Djurovic, Srdjan, additional, Dørum, Erlend D., additional, Espeseth, Thomas, additional, Faraone, Stephen V., additional, Franke, Barbara, additional, Håberg, Asta, additional, Haatveit, Beathe C., additional, Hartman, Catharina, additional, Le Hellard, Stephanie, additional, Heslenfeld, Dirk, additional, Hoekstra, Pieter, additional, Jönsson, Erik G., additional, Kolskår, Knut, additional, Lund, Martina J., additional, Melle, Ingrid, additional, Norbom, Linn B., additional, Nordvik, Jan E., additional, Nyberg, Lars, additional, Oosterlaan, Jaap, additional, Papassotiropoulos, Andreas, additional, Pergola, Giulio, additional, Richard, Genevieve, additional, Sanders, Anne-Marthe, additional, Steen, Vidar M., additional, Ulrichsen, Kristine M., additional, Andreassen, Ole, additional, and Westlye, Lars T., additional

Published
2018
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49. Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study

Author

Demmo, Christine, primary, Lagerberg, Trine V, additional, Kvitland, Levi R, additional, Aminoff, Sofie R, additional, Hellvin, Tone, additional, Simonsen, Carmen, additional, Haatveit, Beathe, additional, Andreassen, Ole A, additional, Melle, Ingrid, additional, and Ueland, Torill, additional

Published
2017
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50. Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

Author

van der Meer, Dennis, Rokicki, Jaroslav, Kaufmann, Tobias, Córdova-Palomera, Aldo, Moberget, Torgeir, Alnæs, Dag, Bettella, Francesco, Frei, Oleksandr, Doan, Nhat Trung, Sønderby, Ida E., Smeland, Olav B., Agartz, Ingrid, Bertolino, Alessandro, Bralten, Janita, Brandt, Christine L., Buitelaar, Jan K., Djurovic, Srdjan, van Donkelaar, Marjolein, Dørum, Erlend S., Espeseth, Thomas, Faraone, Stephen V., Fernández, Guillén, Fisher, Simon E., Franke, Barbara, Haatveit, Beathe, Hartman, Catharina A., Hoekstra, Pieter J., Håberg, Asta K., Jönsson, Erik G., Kolskår, Knut K., Le Hellard, Stephanie, Lund, Martina J., Lundervold, Astri J., Lundervold, Arvid, Melle, Ingrid, Monereo Sánchez, Jennifer, Norbom, Linn C., Nordvik, Jan E., Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pergola, Giulio, de Quervain, Dominique J. F., Richard, Geneviève, Sanders, Anne-Marthe, Selvaggi, Pierluigi, Shumskaya, Elena, Steen, Vidar M., Tønnesen, Siren, Ulrichsen, Kristine M., Zwiers, Marcel P., Andreassen, Ole A., and Westlye, Lars T.

Abstract

The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields’ genetic architecture. T1-weighted brain scans (n= 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic correlation with each other, with other structural brain features and with AD and schizophrenia. All outcome measures were corrected for age, sex and intracranial volume. We found 15 unique genome-wide significant loci across six subfields, of which eight had not been previously linked to the hippocampus. Top SNPs were mapped to genes associated with neuronal differentiation, locomotor behaviour, schizophrenia and AD. The volumes of all the subfields were estimated to be heritable (h2 from 0.14 to 0.27, all p< 1 × 10–16) and clustered together based on their genetic correlations compared with other structural brain features. There was also evidence of genetic overlap of subicular subfield volumes with schizophrenia. We conclude that hippocampal subfields have partly distinct genetic determinants associated with specific biological processes and traits. Taking into account this specificity may increase our understanding of hippocampal neurobiology and associated pathologies.

Published
2020
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