Search

Your search keyword '"Haak, Koen V."' showing total 174 results
Start Over Author "Haak, Koen V."
174 results on '"Haak, Koen V."'

3. Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

Author

Isakoglou, Christina, Haak, Koen V., Wolfers, Thomas, Floris, Dorothea L., Llera, Alberto, Oldehinkel, Marianne, Forde, Natalie J., Oakley, Bethany F. M., Tillmann, Julian, Holt, Rosemary J., Moessnang, Carolin, Loth, Eva, Bourgeron, Thomas, Baron-Cohen, Simon, Charman, Tony, Banaschewski, Tobias, Murphy, Declan G. M., Buitelaar, Jan K., Marquand, Andre F., and Beckmann, Christian F.

Published
2023
Full Text
View/download PDF

6. A shifting role of thalamocortical connectivity in the emergence of large-scale functional brain organization during early lifespan

Author

Park, Shinwon, primary, Haak, Koen V., additional, Oldham, Stuart, additional, Cho, Hanbyul, additional, Byeon, Kyoungseob, additional, Park, Bo-yong, additional, Thomson, Phoebe, additional, Chen, Haitao, additional, Gao, Wei, additional, Xu, Ting, additional, Valk, Sofie, additional, Milham, Michael P., additional, Bernhardt, Boris, additional, Martino, Adriana Di, additional, and Hong, Seok-Jun, additional

Published
2024
Full Text
View/download PDF

9. Connectopic mapping with resting-state fMRI

Author

Haak, Koen V., Marquand, Andre F., and Beckmann, Christian F.

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Neurons and Cognition
Abstract

Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how information is processed in the brain. Here, we propose principled, fully data-driven methods for mapping connectopies using functional magnetic resonance imaging (fMRI) data acquired at rest by combining spectral embedding of voxel-wise connectivity 'fingerprints' with a novel approach to spatial statistical inference. We applied the approach in human primary motor and visual cortex, and show that it can trace biologically plausible, overlapping connectopies in individual subjects that follow these regions' somatotopic and retinotopic maps. As a generic mechanism to perform inference over connectopies, the new spatial statistics approach enables rigorous statistical testing of hypotheses regarding the fine-grained spatial profile of functional connectivity and whether that profile is different between subjects or between experimental conditions. The combined framework offers a fundamental alternative to existing approaches to investigating functional connectivity in the brain, from voxel- or seed-pair wise characterizations of functional association, towards a full, multivariate characterization of spatial topography.

Published
2016
Full Text
View/download PDF

13. Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder

Author

Rausch, Annika, Zhang, Wei, Beckmann, Christian F., Buitelaar, Jan K., Groen, Wouter B., and Haak, Koen V.

Abstract

Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F[subscript 1] = 7.842, p = 0.008) and its volume correlated significantly with symptom severity (social skills: r = 0.548, p = 0.009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway.

Published
2018
Full Text
View/download PDF

18. Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder

Author

Rausch, Annika, Zhang, Wei, Beckmann, Christian F., Buitelaar, Jan K., Groen, Wouter B., and Haak, Koen V.

Subjects
Youth -- Social aspects -- Behavior, Pervasive developmental disorders -- Research, Amygdala (Brain) -- Research, Health
Abstract

Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F.sub.1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway., Author(s): Annika Rausch [sup.1] , Wei Zhang [sup.2] [sup.3] , Christian F. Beckmann [sup.1] [sup.2] [sup.4] , Jan K. Buitelaar [sup.1] [sup.5] , Wouter B. Groen [sup.5] , Koen V. [...]

Published
2018
Full Text
View/download PDF

22. Association of Striatal Connectivity Gradients to Functional Domains Across Psychiatric Disorders

Author

Mulders, Peter C.R., primary, van Eijndhoven, Philip F.P., additional, van Oort, Jasper, additional, Oldehinkel, Marianne, additional, Duyser, Fleur A., additional, Kist, Josina D., additional, Collard, Rose M., additional, Vrijsen, Janna N., additional, Haak, Koen V., additional, Beckmann, Christian F., additional, Tendolkar, Indira, additional, and Marquand, Andre F., additional

Published
2022
Full Text
View/download PDF

23. Connective field modeling

Author

Haak, Koen V., Winawer, Jonathan, Harvey, Ben M., Renken, Remco, Dumoulin, Serge O., Wandell, Brian A., and Cornelissen, Frans W.

Published
2013
Full Text
View/download PDF

39. Genetic influence on contrast sensitivity in young adults

Author

Haak, Koen V.

Subjects
Adult, Male, Aging, medicine.medical_specialty, media_common.quotation_subject, Visual Acuity, Audiology, Biology, Letter to Editor, 050105 experimental psychology, Contrast Sensitivity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Text mining, Reference Values, medicine, Humans, Contrast (vision), 0501 psychology and cognitive sciences, Registries, Sensitivity (control systems), Young adult, Letters to the Editor, media_common, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, 05 social sciences, 220 Statistical Imaging Neuroscience, General Medicine, Middle Aged, Ophthalmology, Female, business, Photic Stimulation, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 204816.pdf (Publisher’s version ) (Open Access)

Published
2019

46. Plasticity, and Its Limits, in Adult Human Primary Visual Cortex

Author

Haak, Koen V, Morland, Antony B, and Engel, Stephen A

Abstract

There is an ongoing debate about whether adult human primary visual cortex (V1) is capable of large-scale cortical reorganization in response to bilateral retinal lesions. Animal models suggest that the visual neural circuitry maintains some plasticity through adulthood, and there are also a few human imaging studies in support this notion. However, the interpretation of these data has been brought into question, because there are factors besides cortical reorganization, such as the presence of sampling bias and/or the unmasking of task-dependent feedback signals from higher level visual areas, that could also explain the results. How reasonable would it be to accept that adult human V1 does not reorganize itself in the face of disease? Here, we discuss new evidence for the hypothesis that adult human V1 is not as capable of reorganization as in animals and juveniles, because in adult humans, cortical reorganization would come with costs that outweigh its benefits. These costs are likely functional and visible in recent experiments on adaptation — a rapid, short-term form of neural plasticity — where they prevent reorganization from being sustained over the long term.

Published
2015

48. Cortical connective field estimates from resting state fMRI activity

Author

Gravel, Nicolás, Harvey, Ben, Nordhjem, Barbara, Haak, Koen V, Dumoulin, Serge O, Renken, Remco, Curčić-Blake, Branislava, Cornelissen, Frans W, Afd Psychologische functieleer, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, Leerstoel Dumoulin, Perceptual and Cognitive Neuroscience (PCN), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Afd Psychologische functieleer, Experimental Psychology (onderzoeksprogramma PF), Helmholtz Institute, and Leerstoel Dumoulin

Subjects
SOMATOSENSORY CORTEX, Visual space, Population, resting state fMRI, population receptive fields, ORGANIZATION, computer.software_genre, Somatosensory system, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Voxel, medicine, Original Research Article, BRAIN, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, VIGILANCE, RS-fMRI, 030304 developmental biology, 0303 health sciences, education.field_of_study, ARCHITECTURE, Resting state fMRI, General Neuroscience, FUNCTIONAL CONNECTIVITY, connectivity mapping, Visual field, REPRESENTATIONS, connective field modeling, population receptive field modeling, PRECISION, Visual cortex, medicine.anatomical_structure, visuotopic maps, Receptive field, visual field mapping, HUMAN VISUAL-CORTEX, Psychology, computer, Neuroscience, 030217 neurology & neurosurgery, MRI
Abstract

One way to study connectivity in visual cortical areas is by examining spontaneous neural activity. In the absence of visual input, such activity remains shaped by the underlying neural architecture and, presumably, may still reflect visuotopic organization. Here, we applied population connective field modeling (CF) to estimate the spatial profile of functional connectivity in the early visual cortex during resting state functional magnetic resonance imaging (RS-fMRI). This model-based analysis estimates the spatial integration between blood-oxygen level dependent (BOLD) signals in distinct cortical visual field maps using fMRI. Just as population receptive field (pRF) mapping predicts the collective neural activity in a voxel as a function of response selectivity to stimulus position in visual space, connective field modeling predicts the activity of voxels in one visual area as a function of the aggregate activity in voxels in another visual area. In combination with pRF mapping, CF locations on the cortical surface can be interpreted in visual space, thus enabling reconstruction of visuotopic maps from resting state data. We demonstrate that V1➤V2 and V1➤V3 connective field maps estimated from resting state fMRI data show visuotopic organization. Therefore, we conclude that –despite some variability in CF estimates between RS scans– neural properties such as CF maps and CF size can be derived from resting state data.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results