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Abstract Background Calycosin may be a potential candidate regarding chemotherapeutic agent, because already some studies against multivarious cancer have been made with this natural compound. Aim This review elucidated a brief overview of previous studies on calycosin potential effects on various cancers and its potential mechanism of action. Methodology Data retrieved by systematic searches of Google Scholar, PubMed, Science Direct, Web of Science, and Scopus by using keywords including calycosin, cancer types, anti‐cancer mechanism, synergistic, and pharmacokinetic and commonly used tools are BioRender, ChemDraw Professional 16.0, and ADMETlab 2.0. Results Based on our review, calycosin is available in nature and effective against around 15 different types of cancer. Generally, the anti‐cancer mechanism of this compound is mediated through a variety of processes, including regulation of apoptotic pathways, cell cycle, angiogenesis and metastasis, oncogenes, enzymatic pathways, and signal transduction process. These study conducted in various study models, including in silico, in vitro, preclinical and clinical models. The molecular framework behind the anti‐cancer effect is targeting some oncogenic and therapeutic proteins and multiple signaling cascades. Therapies based on nano‐formulated calycosin may make excellent nanocarriers for the delivery of this compound to targeted tissue as well as particular organ. This natural compound becomes very effective when combined with other natural compounds and some standard drugs. Moreover, proper use of this compound can reverse resistance to existing anti‐cancer drugs through a variety of strategies. Calycosin showed better pharmacokinetic properties with less toxicity in human bodies. Conclusion Calycosin exhibits excellent potential as a therapeutic drug against several cancer types and should be consumed until standard chemotherapeutics are available in pharma markets.

The paper explores the propulsive power requirements and manoeuvring capabilities of a popular class of inland bulk carriers in Bangladesh. After the initial verification study, model-scale CFD simulations are performed in calm, open waters at different speeds to assess hull resistance. The resistance results are then extrapolated to full scale for calculating propulsion power requirements. Subsequently, manoeuvring simulations are performed using PMM motions to evaluate static drift, pure sway, and pure yaw scenarios to calculate manoeuvring coefficients. Following this, model-scale resistance simulations in restricted waters are performed to estimate the minimum power needed for propulsion in heavy monsoon currents based on common inland waterway dimensions in Bangladesh. Finally, full-scale simulations are performed in open water to investigate the scale effect on resistance (thus power) prediction. The study confirms that the installed power in the vessel is adequate for safe navigation within Bangladesh’s inland waters. Although model-scale CFD studies are generally unsuitable for resistance prediction, the study suggests that extrapolated results often offer conservative estimates for power prediction. In cases of resource limitation, these simulations can prove beneficial since conservative estimations somewhat ensure the vessel’s propulsion and manoeuvrability in extreme conditions.

A mathematical model of solitary wave interaction with a pontoon-type rigid floating structure over a flat bottom is formulated based on Boussinesq-type equations under weakly nonlinear dispersive waves. Based on the higher-order Boussinesq equations, the solitary wave equation is derived, and a semi-analytical solution is obtained using the perturbation technique. On the other hand, brief descriptions of the application of wave2Foam and OceanWave3D on the aforementioned problem are presented. The analytical solitary wave profiles in the outer region are compared with Computational Fluid Dynamics (CFD) and OceanWave 3D model simulations in different cases. The comparison shows a good level of agreement between analytical, wave2Foam, and OceanWave3D. In addition, based on the wave2Foam and coupled OceanWave3D model, the horizontal, vertical wave forces, and the pressure distributions around the pontoon are analysed. Further, the effect of the Ursell number, pontoon length, and water depth on the solitary wave profiles are analysed based on the analytical solution. The paper validates each of the three models and performs intercomparison among them to assess their fidelity and computational burden.

Aerodynamic loads and moments on a naval patrol vessel are investigated using computational fluid dynamic simulations based on the OpenFOAM solver. After the initial turbulence, time, and grid dependency study, model scale simulations were performed for a wide range of inflow angles to predict aerodynamic forces and moments acting on the vessel at different heading conditions. For validation, model scale results were compared with wind tunnel data for similar hull forms. Finally, full-scale simulations were performed for a few cases to investigate possible scale effects on simulation results. The revealed scale effect turned out significant only for the yaw moment response. In this study, we aimed to produce reliable aerodynamic load data for the high-speed vessel, which is essential to developing reliable manoeuvring models. We conclude that Computational Fluid Dynamics is capable of providing reliable aerodynamic load predictions for high-speed vessels with sophisticated superstructures, in an economical manner.

A mathematical model for the problem of wave diffraction by a floating fixed truncated vertical cylinder is formulated based on Boussinesq equations (BEs). Using Bessel functions in the velocity potentials, the mathematical problem is solved for second-order wave amplitudes by applying a perturbation technique and matching conditions. On the other hand, computational fluid dynamics (CFD) simulation results of normalized free surface elevations and wave heights are compared against experimental fluid data (EFD) and numerical data available in the literature. In order to check the fidelity and accuracy of the Boussinesq model (BM), the results of the second-order super-harmonic wave amplitude around the vertical cylinder are compared with CFD results. The comparison shows a good level of agreement between Boussinesq, CFD, EFD, and numerical data. In addition, wave forces and moments acting on the cylinder and the pressure distribution around the vertical cylinder are analyzed from CFD simulations. Based on analytical solutions, the effects of radius, wave number, water depth, and depth parameters at specific elevations on the second-order sub-harmonic wave amplitudes are analyzed.

The International Energy Agency Technology Collaboration Programme for Ocean Energy Systems (OES) initiated the OES Wave Energy Conversion Modelling Task, which focused on the verification and validation of numerical models for simulating wave energy converters (WECs). The long-term goal is to assess the accuracy of and establish confidence in the use of numerical models used in design as well as power performance assessment of WECs. To establish this confidence, the authors used different existing computational modelling tools to simulate given tasks to identify uncertainties related to simulation methodologies: (i) linear potential flow methods; (ii) weakly nonlinear Froude−Krylov methods; and (iii) fully nonlinear methods (fully nonlinear potential flow and Navier−Stokes models). This article summarizes the code-to-code task and code-to-experiment task that have been performed so far in this project, with a focus on investigating the impact of different levels of nonlinearities in the numerical models. Two different WECs were studied and simulated. The first was a heaving semi-submerged sphere, where free-decay tests and both regular and irregular wave cases were investigated in a code-to-code comparison. The second case was a heaving float corresponding to a physical model tested in a wave tank. We considered radiation, diffraction, and regular wave cases and compared quantities, such as the WEC motion, power output and hydrodynamic loading.

Objectives: Early childhood nutrition is critical for physical and mental development, and any hindrance (malnutrition) at this stage adversely affects adulthood which makes them more susceptible to a variety of communicable and non-communicable diseases. St. Martin’s Island was the focus of this study, which examined the prevalence and risk factors for malnutrition among under-five children. Methods: In this cross-sectional study, 256 children aged under five were assessed for anthropometry, and multiple logistic regression models were fitted to identify potential predictors of malnutrition. For analysis, SPSS and WHO Anthro software were used. Results: The prevalence of stunting, wasting, underweight, and overweight were 34.4%, 17.6%, 18.9%, and 6.9% respectively among children under-five years of age in St. Martin’s Island. An increase in child’s age decreases their risk of being stunted (AOR = 0.97, p = 0.006). Males were more likely than females to be wasted (AOR = 2.03, p = 0.001). Both stunting (AOR = 2.42, p = 0.004) and wasting (AOR = 2.82, p = 0.015) rate were higher among the poorer section as compared to the richest. On the contrary, underweight was low among the poorest section (AOR = 0.37, p = 0.024). Other socio-economic factors, for example, household food insecurity, and parental occupation affect these forms of malnutrition significantly. Conclusion: Prevalence of all forms of malnutrition except underweight was higher as compared to the national perspective in St. Martin’s Island among the under-five children. Community-based approaches by the local government in collaboration with various non-government organizations should be taken to reduce and prevent malnutrition among children.

Objectives: This study aimed to outline water, sanitation, and hygiene (WASH) practices for children under 5 years of age among the households of St. Martin’s Island as well as examine the role of water, sanitation, and hygiene on child nutritional outcomes. Methods: A total of 256 children under 5 years of age were anthropometrically measured, and multiple linear regression was performed to understand the relationship between combined water, sanitation, and hygiene score and child nutritional outcomes: height-for-age, weight-for-age, weight-for-height z -scores. Results: The majority of the sampled households had improved drinking water facilities. Over one-third of the participants (36.5%) did not have access to better sanitation, and 12.4% reported defecating in open places. Just over one-third of those surveyed reported washing their hands with soap or detergents after defecation, with more than 22% of people not having access to a handwashing station on their premises. Stunting, wasting, and underweight were found to be prevalent in 34.4%, 17.6%, and 18.9% of the sampled children, respectively. Height-for-age (0.08 SDs) and weight-for-age (0.014 SDs) were greater on average in children from households with improved water, sanitation, and hygiene conditions, but weight-for-height did not significantly differ from those from WASH-unimproved households. Conclusion: Certain aspects of WASH, particularly, sanitation facilities and hygiene practices were not up to the mark in St. Martin’s Island, and consistent with findings from other studies, our study findings underlined the potential benefits of improved water, sanitation, and hygiene practices in addressing child undernutrition.